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https://www.readbyqxmd.com/read/29055123/disruption-of-behavior-and-brain-metabolism-in-artificially-reared-rats
#1
Elsa L Aguirre-Benítez, Mercedes G Porras, Leticia Parra, Jacquelina González-Ríos, Dafne F Garduño-Torres, Damaris Albores-García, Arturo Avendaño, Miguel A Ávila-Rodríguez, Angel I Melo, Ismael Jiménez-Estrada, Ma Eugenia Mendoza-Garrido, César Toriz, Daniel Diaz, Elizabeth Ibarra-Coronado, Karina Mendoza-Ángeles, Jesús Hernández-Falcón
Early adverse life-stress has been associated to behavioral disorders that can manifest as inappropriate or aggressive responses to social challenges. In this study, we analyzed the effects of artificial rearing on the open field and burial behavioral tests and on GFAP, c-Fos immunoreactivity and glucose metabolism measured in anxiety related brain areas. Artificial rearing of male rats was performed by supplying artificial milk through a cheek cannula and tactile stimulation, mimicking the mother's licking to rat pups from the 4(th) postnatal day until weaning...
October 21, 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/29055022/the-addition-of-a-developmental-factor-unc-62-to-already-long-lived-worms-increases-lifespan-and-healthspan
#2
Dror Sagi
Aging is a complex trait that is affected by multiple genetic pathways. A relatively unexplored approach is to manipulate multiple independent aging pathways simultaneously in order to observe their cumulative effect on lifespan. Here, we report the phenotypic characterization of a strain with changes in five aging pathways: 1) mitochondrial ROS production, 2) innate immunity, 3) stress response, 4) metabolic control and 5) developmental regulation in old age. The quintuply-modified strain has a lifespan that is 160% longer than the transgenic control strain...
October 20, 2017: Biology Open
https://www.readbyqxmd.com/read/29054925/platelet-mitochondrial-dysfunction-and-the-correlation-with-human-diseases
#3
REVIEW
Li Wang, Qiang Wu, Zhijia Fan, Rufeng Xie, Zhicheng Wang, Yuan Lu
The platelet is considered as an accessible and valuable tool to study mitochondrial function, owing to its greater content of fully functional mitochondria compared with other metabolically active organelles. Different lines of studies have demonstrated that mitochondria in platelets have function far more than thrombogenesis regulation, and beyond hemostasis, platelet mitochondrial dysfunction has also been used for studying mitochondrial-related diseases. In this review, the interplay between platelet mitochondrial dysfunction and oxidative stress, mitochondrial DNA lesions, electron transfer chain impairments, mitochondrial apoptosis and mitophagy has been outlined...
October 20, 2017: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29054837/altered-metabolic-landscape-in-idh-mutant-gliomas%C3%A2-affects-phospholipid-energy-and-oxidative-stress-pathways
#4
Fred Fack, Saverio Tardito, Guillaume Hochart, Anais Oudin, Liang Zheng, Sabrina Fritah, Anna Golebiewska, Petr V Nazarov, Amandine Bernard, Ann-Christin Hau, Olivier Keunen, William Leenders, Morten Lund-Johansen, Jonathan Stauber, Eyal Gottlieb, Rolf Bjerkvig, Simone P Niclou
Heterozygous mutations in NADP-dependent isocitrate dehydrogenases (IDH) define the large majority of diffuse gliomas and are associated with hypermethylation of DNA and chromatin. The metabolic dysregulations imposed by these mutations, whether dependent or not on the oncometabolite D-2-hydroxyglutarate (D2HG), are less well understood. Here, we applied mass spectrometry imaging on intracranial patient-derived xenografts of IDH-mutant versus IDH wild-type glioma to profile the distribution of metabolites at high anatomical resolution in situ This approach was complemented by in vivo tracing of labeled nutrients followed by liquid chromatography-mass spectrometry (LC-MS) analysis...
October 20, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29054673/fluvial-biofilms-exposed-to-desiccation-and-pharmaceutical-pollution-new-insights-using-metabolomics
#5
Albert Serra-Compte, Natàlia Corcoll, Belinda Huerta, Sara Rodríguez-Mozaz, Sergi Sabater, Damià Barceló, Diana Álvarez-Muñoz
In many arid and semi-arid systems, biological communities in river ecosystems are submitted to flow interruption and desiccation, as well as to the impact of urban wastewaters. In this work, we studied (using a LC-LTQ-Orbitrap) the metabolomic response of biofilm communities exposed to both hydrological and chemical stressors. Fluvial biofilms were exposed to a mixture of 9 pharmaceuticals at a total concentration of 5000ng/L (mimicking concentrations and compounds found in polluted aquatic environments) and/or to seven days of desiccation, under laboratory conditions...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29054661/coordinated-role-of-soluble-and-cell-wall-bound-phenols-is-a-key-feature-of-the-metabolic-adjustment-in-a-mining-woody-fleabane-dittrichia-viscosa-l-population-under-semi-arid-conditions
#6
Antonio López-Orenes, María C Bueso, Isabel M Párraga-Aguado, Antonio A Calderón, María A Ferrer
Environmental contamination by hazardous heavy metals/metalloids (metal(loid)s) is growing worldwide. To restrict the migration of toxic contaminants, the establishment of a self-sustainable plant cover is required. Plant growth in multi-polluted soils is a challenging issue not only by metal(loid) toxicities, but also by the co-occurrence of other stressors. Dittrichia viscosa is a pioneer Mediterranean species able to thrive in metal(loid)-enriched tailings in semi-arid areas. The aim of the present work was to examine the metabolic adjustments involved in the acclimation responses of this plant to conditions prevailing in mine-tailings during Mediterranean spring and summer...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29054537/calcium-signaling-at-the-endoplasmic-reticulum-fine-tuning-stress-responses
#7
REVIEW
Amado Carreras-Sureda, Philippe Pihán, Claudio Hetz
Endoplasmic reticulum (ER) calcium signaling is implicated in a myriad of coordinated cellular processes. The ER calcium content is tightly regulated as it allows a favorable environment for protein folding, in addition to operate as a major reservoir for fast and specific release of calcium. Altered ER homeostasis impacts protein folding, activating the unfolded protein response (UPR) as a rescue mechanism to restore proteostasis. ER calcium release impacts mitochondrial metabolism and also fine-tunes the threshold to undergo apoptosis under chronic stress...
August 20, 2017: Cell Calcium
https://www.readbyqxmd.com/read/29054416/targeting-the-selenoprotein-thioredoxin-reductase-1-for-anticancer-therapy
#8
Elias S J Arnér
The cytosolic selenoprotein thioredoxin reductase 1 (TrxR1, encoded in human by TXNRD1) is implied to have several different roles in relation to cancer. Its physiologic functions may protect normal cells from carcinogenesis, but may also promote cancer progression if carcinogenesis nonetheless occurs. With distinct links to Nrf2 signaling, ribonucleotide reductase-dependent production of deoxyribonucleotides and its support of several antioxidant systems counteracting oxidative stress, the metabolic pathways regulated, and affected by TrxR1, are altogether of crucial importance in cancer...
2017: Advances in Cancer Research
https://www.readbyqxmd.com/read/29054323/human-kidney-stone-matrix-latent-potential-to-restrain-com-induced-cytotoxicity-and-inflammatory-response
#9
Shifa Narula, Simran Tandon, Prakash Baligar, Shrawan Kumar Singh, Chanderdeep Tandon
Kidney stone disease is a multi-factorial disorder resulting from the interplay of various risk factors including lifestyle, environment and genetics along with metabolic activities inside the body. However, it is difficult to determine how these factors converge to promote stone disease. Extensive investigations of kidney stone composition at the molecular level have been carried out however; its impact on the complex mechanism of stone formation is still obscure. Hence, an in vitro study was designed to investigate the attenuation of calcium oxalate toxicity by human kidney stone matrix proteins on NRK-52E cells using flowcytometry, Western blotting, RT-PCR and immunofluorescence assays...
October 17, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29054271/peptide-hormones-as-tumor-markers-in-clinical-practice
#10
Qian Sun, Zhen Zhao
Peptide hormones represent a major class of hormones that are made from amino acids by specialized endocrine glands. The maturation of bioactive hormones take place in the rough endoplasmic reticulum and Golgi apparatus, where preprohormones are proteolytically cleaved into prohormones, and subsequently into mature peptide hormones. Once the bioactive hormones are released into the circulation, they interact with receptors located on the plasma membrane of target cells, and initiate intracellular signaling pathways to regulate physiological processes including energy metabolism, growth, stress, and reproduction...
2017: Enzymes
https://www.readbyqxmd.com/read/29054187/accuracy-of-exercise-tolerance-test-in-the-diagnosis-of-coronary-artery-disease-in-patients-with-left-dominant-coronary-circulation
#11
Armin Attar, Arman Mehrzadeh, Mohsen Foulad, Davar Aldavood, Mohammad Amin Fallahzadeh, Mohammad Assadian Rad, Shahdad Khosropanah
BACKGROUND: Exercise is a physiologic stress that helps the physicians to clarify the presence or absence of cardiovascular disease which may be obscure at rest. Although it is sensitive, its specificity is affected by several parameters, such as some metabolic conditions, some structural heart diseases, and some baseline electrocardiogram abnormalities. Currently, the relationship between coronary dominance and accuracy of EET is not examined. Therefore, this study was conducted to determine the potential impact of coronary dominance on the accuracy of EET...
September 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/29054115/reversible-mono-adp-ribosylation-of-dna-breaks
#12
Deeksha Munnur, Ivan Ahel
ADP-ribosylation is a chemical modification of macromolecules that plays an important role in regulation of quintessential biological processes such as DNA repair, transcription, chromatin remodelling, stress response, apoptosis, bacterial metabolism and many others. ADP-ribosylation is carried out by ADP-ribosyltransferase proteins, such as poly(ADP-ribose) polymerases (PARPs) that transfer either monomer or polymers of ADP-ribose onto the molecular targets by using nicotinamide adenine dinucleotide (NAD(+) ) as a cofactor...
October 20, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29054078/subacute-oral-toxicity-assessment-of-benalaxyl-in-mice-based-on-metabolomics-methods
#13
Xinru Wang, Dezhen Wang, Zhiqiang Zhou, Wentao Zhu
In this study, the metabolic responses of mice after 30 days of exposure to benalaxyl were assessed using NMR-based untargeted metabolomics and LC-MS-based targeted profiling of 20 amino acids. Urinary (1)H NMR analyses revealed alterations in energy metabolism, lipid metabolism, vitamin B metabolism, the urea cycle and amino acid metabolism, and targeted analyses indicated that the serum levels of asparagine, histidine, lysine and aspartic acid were significantly altered. Additionally, significant oxidative stress was observed in the liver and kidney, although no apparent histopathological injury was observed...
October 15, 2017: Chemosphere
https://www.readbyqxmd.com/read/29053995/effects-of-a-whey-protein-supplementation-on-oxidative-stress-body-composition-and-glucose-metabolism-among-overweight-people-affected-by-diabetes-mellitus-or-impaired-fasting-glucose-a-pilot-study
#14
Chiara Flaim, Michael Kob, Angela M Di Pierro, Markus Herrmann, Lucio Lucchin
Obesity and diabetes mellitus type 2 (DM2) are characterized by chronic inflammation and oxidative stress [Donath et al. 2013] and this leads to cardiovascular diseases [Hulsmans & Holvoet 2010]. Whey proteins (WP) have antioxidant [Chitapanarux et al. 2009], anti-inflammatory [Sugawara et al. 2012] and hypoglycemic activities [Mignone et al. 2015], while data on weight, body composition [Frestedt et al. 2008; Aldrich et al. 2011] and blood pressure are conflicting [Kawase et al. 2000; Lee et al. 2007]. WP have unpleasant taste and smell [Patel 2015], but a new WP isolate (ProLYOtin®) seems to be more palatable...
May 20, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29053962/identification-of-up-regulated-genes-from-the-metal-hyperaccumulator-aquatic-fern-salvinia-minima-baker-in-response-to-lead-exposure
#15
Daniel A Leal-Alvarado, A Martínez-Hernández, C L Calderón-Vázquez, D Uh-Ramos, G Fuentes, J H Ramírez-Prado, L Sáenz-Carbonell, J M Santamaría
Lead (Pb) is one of the most serious environmental pollutants. The aquatic fern Salvinia minima Baker is capable to hyper-accumulate Pb in their tissues. However, the molecular mechanisms involved in its Pb accumulation and tolerance capacity are not fully understood. In order to investigate the molecular mechanisms that are activated by S. minima in response to Pb, we constructed a suppression subtractive hybridization library (SSH) in response to an exposure to 40μM of Pb(NO3)2 for 12h. 365 lead-related differentially expressed sequences tags (ESTs) were isolated and sequenced...
October 16, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29053928/heat-stress-risk-profiles-for-three-non-woven-coveralls
#16
Ximena P Garzón-Villalba, Yougui Wu, Candi D Ashley, Thomas E Bernard
The ACGIH® Threshold Limit Value® (TLV®) is used to limit heat stress exposures so that most workers can maintain thermal equilibrium. That is, the TLV was set to an upper limit of Sustainable exposures for most people. This paper addresses the ability of the TLV to differentiate between Sustainable and Unsustainable heat exposures for four clothing ensembles over a range of environmental factors and metabolic rates (M). The four clothing ensembles (woven clothing, and particle barrier, water barrier and vapor barrier coveralls) represented a wide range of evaporative resistances...
October 20, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/29053811/effects-of-the-supplemental-chromium-form-on-performance-and-oxidative-stress-in-broilers-exposed-to-heat-stress
#17
N Sahin, A Hayirli, C Orhan, M Tuzcu, F Akdemir, J R Komorowski, K Sahin
This experiment was conducted to investigate effects of the organic complex form of supplemental chromium (Cr) on performance, oxidative stress markers, and serum profile in broilers exposed to heat stress (HS). A total of 1,200 10-day-old boilers (Ross-308) was divided into one of the 6 treatments (2 environmental temperatures x 3 diets with different Cr forms). The birds were kept in temperature-controlled rooms at either 22 ± 2°C 24 h/d (thermoneutral, TN group) or 34 ± 2°C for 8 h/d, 08:00 to 17:00 h, followed by 22°C for 16 h (HS group) and fed either a basal diet (C) or the basal diet supplemented with Cr (200 μg/kg) through 1...
September 20, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053671/cell-free-biochemical-fluorometric-enzymatic-assay-for-high-throughput-measurement-of-lipid-peroxidation-in-high-density-lipoprotein
#18
Shubhendu Sen Roy, Huy Cong Xuan Nguyen, Thomas A Angelovich, Anna C Hearps, Diana Huynh, Anthony Jaworowski, Theodoros Kelesidis
Low high-density lipoprotein cholesterol (HDL-C) levels are one of the most powerful independent negative predictors of atherosclerotic cardiovascular disease (CVD). The structure and function of HDL rather than HDL-C may more accurately predict atherosclerosis. Several HDL protein and lipid compositional changes that impair HDL function occur in inflammatory states such as atherosclerosis. HDL function is usually determined by cell based assays such as cholesterol efflux assay but these assays have numerous drawbacks lack of standardization...
October 12, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29053618/the-application-of-ultra-high-performance-liquid-chromatography-coupled-with-a-ltq-orbitrap-mass-technique-to-reveal-the-dynamic-accumulation-of-secondary-metabolites-in-licorice-under-aba-stress
#19
Da Li, Guojie Xu, Guangxi Ren, Yufeng Sun, Ying Huang, Chunsheng Liu
The traditional medicine licorice is the most widely consumed herbal product in the world. Although much research work on studying the changes in the active compounds of licorice has been reported, there are still many areas, such as the dynamic accumulation of secondary metabolites in licorice, that need to be further studied. In this study, the secondary metabolites from licorice under two different methods of stress were investigated by ultra-high-performance liquid chromatography coupled with hybrid linear ion trap-Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap-MS)...
October 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29052811/four-saccharomyces-species-differ-in-their-tolerance-to-various-stresses-though-they-have-similar-basic-physiological-parameters
#20
Jana Zemančíková, Marie Kodedová, Klára Papoušková, Hana Sychrová
Saccharomyces species, which are mostly used in the food and beverage industries, are known to differ in their fermentation efficiency and tolerance of adverse fermentation conditions. However, the basis of their difference has not been fully elucidated, although their genomes have been sequenced and analyzed. Five strains of four Saccharomyces species (S. cerevisiae, S. kudriavzevii, S. bayanus, and S. paradoxus), when grown in parallel in laboratory conditions, exhibit very similar basic physiological parameters such as membrane potential, intracellular pH, and the degree to which they are able to quickly activate their Pma1 H(+)-ATPase upon glucose addition...
October 20, 2017: Folia Microbiologica
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