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https://www.readbyqxmd.com/read/28458119/tnm-classification-and-the-need-for-revision-of-pn3a-breast-cancer
#1
T J A van Nijnatten, M Moossdorff, L de Munck, B Goorts, M L G Vane, K B M I Keymeulen, R G H Beets-Tan, M B I Lobbes, M L Smidt
BACKGROUND: According to the seventh edition of tumour-node-metastasis (TNM) classification, pN3a status in breast cancer patients consists of presence of an infraclavicular lymph node metastasis (LNM) and/or presence of ≥10 axillary LNMs. The aim of this study was to determine whether prognosis of pN3a based on at least an infraclavicular LNM differs from ≥10 axillary LNMs. METHODS: Data were obtained from the Netherlands Cancer Registry. All patients were diagnosed between 2005 and 2008 with primary invasive epithelial breast cancer and pN2a or pN3a status as pathologic result...
April 26, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28445211/polypoidal-choroidal-vasculopathy-associated-with-central-serous-chorioretinopathy-pachychoroid-spectrum-of-diseases
#2
George J Manayath, Vanee Sheth Shah, Veerappan R Saravanan, Venkatapathy Narendran
PURPOSE: To study multimodal imaging features of polypoidal choroidal vasculopathy (PCV) associated with central serous chorioretinopathy (CSC) in the same eye. METHODS: A retrospective observational study of cases of suspected PCV which underwent indocyanine green angiography, fundus fluorescein angiography and optical coherence tomography was done, to look for simultaneous typical CSC-like active leak in the same eye. The relevant history, best-corrected visual acuity, optical coherence tomography, fundus fluorescein angiography, and indocyanine green angiography findings were analyzed...
April 25, 2017: Retina
https://www.readbyqxmd.com/read/28442549/neuraminidases-3-and-4-regulate-neuronal-function-by-catabolizing-brain-gangliosides
#3
Xuefang Pan, Camila De Britto Pará De Aragão, Juan P Velasco-Martin, David A Priestman, Harry Y Wu, Kohta Takahashi, Kazunori Yamaguchi, Luisella Sturiale, Domenico Garozzo, Frances M Platt, Nathalie Lamarche-Vane, Carlos R Morales, Taeko Miyagi, Alexey V Pshezhetsky
Gangliosides (sialylated glycolipids) play an essential role in the CNS by regulating recognition and signaling in neurons. Metabolic blocks in processing and catabolism of gangliosides result in the development of severe neurologic disorders, including gangliosidoses manifesting with neurodegeneration and neuroinflammation. We demonstrate that 2 mammalian enzymes, neuraminidases 3 and 4, play important roles in catabolic processing of brain gangliosides by cleaving terminal sialic acid residues in their glycan chains...
April 25, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28394641/exploring-validation-of-a-graphic-symbol-questionnaire-to-measure-participation-experiences-of-youth-in-activity-settings
#4
Beata Batorowicz, Gillian King, Freda Vane, Madhu Pinto, Parimala Raghavendra
Participation has a subjective and private dimension, and so it is important to hear directly from youth about their experiences in various activity settings, the places where they "do things" and interact with others. To meet this need, our team developed the Self-Reported Experiences of Activity Settings (SEAS) measure, which demonstrated good-to-excellent measurement properties. To address the needs of youth who could benefit from graphic symbol support, the SEAS-PCS(TM), (1) was created. The purpose of this paper is to describe the development of SEAS-PCS and the preliminary study that explores the equivalency of the SEAS and SEAS-PCS...
April 10, 2017: Augmentative and Alternative Communication: AAC
https://www.readbyqxmd.com/read/28379550/does-passive-sampling-accurately-reflect-the-bee-apoidea-anthophila-communities-pollinating-apple-and-sour-cherry-orchards
#5
Jason Gibbs, Neelendra K Joshi, Julianna K Wilson, Nikki L Rothwell, Karen Powers, Mike Haas, Larry Gut, David J Biddinger, Rufus Isaacs
During bloom of spring orchard crops, bees are the primary providers of pollination service. Monitoring these insects for research projects is often done by timed observations or by direct aerial netting, but there has been increasing interest in blue vane traps as an efficient passive approach to collecting bees. Over multiple spring seasons in Michigan and Pennsylvania, orchards were monitored for wild bees using timed netting from crop flowers and blue vane traps. This revealed a distinctly different community of wild bees captured using the two methods, suggesting that blue vane traps can complement but cannot replace direct aerial netting...
March 31, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/28372759/on-road-emissions-of-co-co2-and-nox-from-four-wheeler-and-emission-estimates-for-delhi
#6
Jaiprakash, Gazala Habib, Anil Kumar, Akash Sharma, Minza Haider
This study presents the emission factor of gaseous pollutants (CO, CO2, and NOX) from on-road tailpipe measurement of 14 passenger cars of different types of fuel and vintage. The trolley equipped with stainless steel duct, vane probe velocity meter, flue gas analyzer, Nondispersive infra red (NDIR) CO2 analyzer, temperature, and relative humidity (RH) sensors was connected to the vehicle using a towing system. Lower CO and higher NOX emissions were observed from new diesel cars (post 2010) compared to old cars (post 2005), which implied that new technological advancement in diesel fueled passenger cars to reduce CO emission is a successful venture, however, the use of turbo charger in diesel cars to achieve high temperature combustion might have resulted in increased NOX emissions...
March 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28356391/tlr4-signals-in-b-lymphocytes-are-transduced-via-the-b-cell-antigen-receptor-and-syk
#7
Edina Schweighoffer, Josquin Nys, Lesley Vanes, Nicholas Smithers, Victor L J Tybulewicz
Toll-like receptors (TLRs) play an important role in immune responses to pathogens by transducing signals in innate immune cells in response to microbial products. TLRs are also expressed on B cells, and TLR signaling in B cells contributes to antibody-mediated immunity and autoimmunity. The SYK tyrosine kinase is essential for signaling from the B cell antigen receptor (BCR), and thus for antibody responses. Surprisingly, we find that it is also required for B cell survival, proliferation, and cytokine secretion in response to signaling through several TLRs...
May 1, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28329643/epidemiology-of-lentigo-maligna-and-lentigo-maligna-melanoma-in-the-netherlands-1989-2013
#8
Karin Greveling, Marlies Wakkee, Tamar Nijsten, Renate R Vane den Bos, Loes M Hollestein
Lentigo maligna (LM) is considered a precursor to LM melanoma (LMM). We assessed trends in LM and LMM incidence rates between 1989 and 2013 in the Netherlands, and estimated the risk of a LMM after LM. Data on newly diagnosed LM and LMM were obtained from the Netherlands Cancer Registry and PALGA (Dutch Pathology Database). Age-standardized incidence rates (European standardized rate [ESR]), estimated annual percentage changes (EAPC), and the cumulative incidence of LMM after LM were calculated. Between 1989-2013, 10,545 patients were diagnosed with a primary LM and 2,898 with a primary LMM in the Netherlands...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28325856/prevalence-of-undiagnosed-asymptomatic-bacteriuria-and-associated-risk-factors-during-pregnancy-a-cross-sectional-study-at-two-tertiary-centres-in-cairo-egypt
#9
Mohamed Abdel-Aziz Elzayat, Ashton Barnett-Vanes, Mohamed Farag Elmorsy Dabour, Feng Cheng
BACKGROUND: The prevalence of asymptomatic bacteriuria (ASB) during pregnancy is poorly understood in Egypt-a country with a high birth rate. OBJECTIVES: To determine the prevalence of ASB among pregnant women booking at El Hussein and Sayed Galal Hospitals in Al-Azhar University in Egypt; and to observe the relationship between ASB prevalence and risk factors such as socioeconomic level and personal hygiene. SETTING: Obstetrics and gynaecology clinics of 2 university hospitals in the capital of Egypt...
March 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28282931/bee-community-of-commercial-potato-fields-in-michigan-and-bombus-impatiens-visitation-to-neonicotinoid-treated-potato-plants
#10
Amanda L Buchanan, Jason Gibbs, Lidia Komondy, Zsofia Szendrei
We conducted a bee survey in neonicotinoid-treated commercial potato fields using bowl and vane traps in the 2016 growing season. Traps were placed outside the fields, at the field edges, and 10 and 30 m into the fields. We collected 756 bees representing 58 species, with Lasioglossum spp. comprising 73% of all captured bees. We found seven Bombus spp., of which B. impatiens was the only known visitor of potato flowers in our region. The majority of the bees (68%) were collected at the field edges and in the field margins...
March 9, 2017: Insects
https://www.readbyqxmd.com/read/28269012/cfd-analysis-of-strut-influence-on-blood-flow-in-stent-implanted-left-main-coronary-artery-bifurcation
#11
Yuya Yamada, Takahiro Tsukahara, Masahiro Motosuke, Yusuke Fujino
We numerically studied blood flows in a simulated branching pipe of coronary artery bifurcation, which is affected by stent implantation. We found that stent struts provide effects as guide vanes and blockages on the flow into circumflex branch. The former effect increases the flow rate and shear stress on the arteriosclerosis-prone site. The blockage effect may overwhelm the guide effect depending on a strut position against the inflow.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28262070/developing-a-website-to-demonstrate-clinical-holding-techniques
#12
Andrea Page, Alison Warren, Nicola Vanes
Healthcare staff routinely use clinical holding to help infants, children or young people stay still when treatment is being administered, to prevent children or young people from interfering with the treatment, or when invasive examinations are being carried out. However, healthcare staff rarely have any formal discussion with children and young people, or their parents, on the techniques used for clinical holding. Visual tools are important when talking to children or young people about their healthcare, and a website with images of clinical holds would allow staff to discuss relevant holds with their patients...
March 6, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/28260833/development-of-noise-controls-for-longwall-shearer-cutting-drums
#13
Hugo E Camargo, Amanda S Azman, Lynn Alcorn
Noise-induced hearing loss is the second most pervasive disease in the mining industry. The exposure of miners to noise levels above the permissible exposure level results in hearing loss of approximately 80% of coal miners by retirement age. In addition, between 2002 and 2011, approximately 48% of longwall shearer operators were overexposed in coal mines in the United States. Previous research identified the two rotating cutting drums used by the longwall shearer to extract coal as the most significant sound-radiating components...
September 1, 2016: Noise Control Engineering Journal
https://www.readbyqxmd.com/read/28255996/distribution-of-the-characteristics-of-barbs-and-barbules-on-barn-owl-wing-feathers
#14
Matthias Weger, Hermann Wagner
Owls are known for the development of a silent flight. One conspicuous specialization of owl wings that has been implied in noise reduction and that has been demonstrated to change the aerodynamic behavior of the wing is a soft dorsal wing surface. The soft surface is a result of changes in the shape of feather barbs and barbules in owls compared with other bird species. We hypothesized that as the aerodynamic characteristics of a wing change along its chordwise and spanwise direction, so may the shape of the barbs and barbules...
March 3, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28227224/cfd-analysis-of-strut-influence-on-blood-flow-in-stent-implanted-left-main-coronary-artery-bifurcation
#15
Yuya Yamada, Takahiro Tsukahara, Masahiro Motosuke, Yusuke Fujino, Yuya Yamada, Takahiro Tsukahara, Masahiro Motosuke, Yusuke Fujino, Takahiro Tsukahara, Yuya Yamada, Yusuke Fujino, Masahiro Motosuke
We numerically studied blood flows in a simulated branching pipe of coronary artery bifurcation, which is affected by stent implantation. We found that stent struts provide effects as guide vanes and blockages on the flow into circumflex branch. The former effect increases the flow rate and shear stress on the arteriosclerosis-prone site. The blockage effect may overwhelm the guide effect depending on a strut position against the inflow.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28163870/features-of-owl-wings-that-promote-silent-flight
#16
REVIEW
Hermann Wagner, Matthias Weger, Michael Klaas, Wolfgang Schröder
Owls are an order of birds of prey that are known for the development of a silent flight. We review here the morphological adaptations of owls leading to silent flight and discuss also aerodynamic properties of owl wings. We start with early observations (until 2005), and then turn to recent advances. The large wings of these birds, resulting in low wing loading and a low aspect ratio, contribute to noise reduction by allowing slow flight. The serrations on the leading edge of the wing and the velvet-like surface have an effect on noise reduction and also lead to an improvement of aerodynamic performance...
February 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/28160981/corrigendum-to-significance-of-dissolved-methane-in-effluents-of-anaerobically-treated-low-strength-wastewater-and-potential-for-recovery-as-an-energy-product-a-review-water-res-104-2016-520-531
#17
Brian C Crone, Jay L Garland, George A Sorial, Leland M Vane
No abstract text is available yet for this article.
February 1, 2017: Water Research
https://www.readbyqxmd.com/read/28135249/the-cdc42-rac1-regulator-cdgap-is-a-novel-e-cadherin-transcriptional-co-repressor-with-zeb2-in-breast-cancer
#18
Y He, J J Northey, A Pelletier, Z Kos, L Meunier, B Haibe-Kains, A-M Mes-Masson, J-F Côté, P M Siegel, N Lamarche-Vane
The loss of E-cadherin causes dysfunction of the cell-cell junction machinery, which is an initial step in epithelial-to-mesenchymal transition (EMT), facilitating cancer cell invasion and the formation of metastases. A set of transcriptional repressors of E-cadherin (CDH1) gene expression, including Snail1, Snail2 and Zeb2 mediate E-cadherin downregulation in breast cancer. However, the molecular mechanisms underlying the control of E-cadherin expression in breast cancer progression remain largely unknown...
January 30, 2017: Oncogene
https://www.readbyqxmd.com/read/28118925/treatment-of-the-first-bite-syndrome
#19
María Costales-Marcos, Fernando López Álvarez, Laura Fernández-Vañes, Justo Gómez, José Luis Llorente
First bite syndrome is a potential complication of surgery involving the infratemporal fossa, deep lobe of the parotid gland and parapharyngeal space. It is described as an acute and intense pain in the parotid region caused with the first bite of each meal. It is related to damage to sympathetic innervation of the parotid gland. Parasympathetic hyperactivation is believed to stimulate an exaggerated myoepithelial cell contraction causing pain. Usual analgesic treatments have poor results. Botulinum toxin type A causes parasympathetic nerve paralysis of the parotid gland and this fact would minimize salivation and decrease first bite syndrome...
January 21, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28110860/results-of-total-laryngectomy-as-treatment-for-locally-advanced-hypopharyngeal-cancer
#20
Patricia García-Cabo Herrero, Laura Fernández-Vañes, Fernando López Álvarez, César Álvarez Marcos, José Luis Llorente, Juan Pablo Rodrigo
INTRODUCTION AND OBJECTIVES: Total laryngectomy (TL), with eventual postoperative radiotherapy, has proven to be effective in treating cases of locally advanced hypopharyngeal cancer. The aim of this study was to analyse the oncological outcomes of this procedure in patients with hypopharyngeal cancer classified T3 and T4. METHODS: We studied 59 patients (33 T3 and 26 T4a) with primary squamous cell carcinoma of the hypopharynx treated with TL from 1998 to 2012...
January 19, 2017: Acta Otorrinolaringológica Española
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