keyword
https://read.qxmd.com/read/38533435/effects-of-dexmedetomidine-on-postoperative-pain-and-early-cognitive-impairment-in-older-male-patients-undergoing-laparoscopic-cholecystectomy
#1
JOURNAL ARTICLE
Yanlong Fu, Qiang Wei, Zhenliang Wang, Qingtao Zhao, Wenxin Shi
The primary aim of the present study was to investigate the effect of dexmedetomidine (DEX) on postoperative pain and early cognitive impairment in old male patients, who underwent laparoscopic cholecystectomy (LC). A total of 97 old patients, subjected to LC at the 980 Hospital of the Joint Service Support Force of the People's Liberation Army of China, were randomly divided into two groups, namely the DEX and normal saline groups. Patients in the DEX group received an intravenous infusion of 0.8 µg/kg DEX within 10 min following general anesthesia, followed by a maintenance infusion of 0...
May 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38532827/biomarkers-of-chronic-inflammation-and-cognitive-decline-a-prospective-observational-study
#2
JOURNAL ARTICLE
Bhavna A Guduguntla, Alexi Vasbinder, Elizabeth Anderson, Tariq U Azam, Pennelope Blakely, Noah J Webster, Richard Gonzalez, Toni Atonucci, Judith L Heidebrink, Bruno Giordani, Laura Zahodne, Benjamin M Hampstead, Kristine J Ajrouch, Salim S Hayek
We sought to determine whether the biomarkers of chronic inflammation predict cognitive decline in a prospective observational study. We measured baseline serum soluble urokinase plasminogen activator receptor (suPAR) and high sensitivity C-reactive protein (hs-CRP) levels in 282 participants of the University of Michigan Memory and Aging Project. Cognitive function was measured using the Montreal Cognitive Assessment (MoCA) and the Clinical Dementia Rating (CDR) scale for up to five time points. SuPAR and hs-CRP levels were not significantly higher in participants with mild cognitive impairment ( n  = 97) or dementia ( n  = 59), compared to those with normal cognitive function ( n  = 126)...
2024: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/38529861/-identifying-the-neurostimulation-target-for-treatment-of-cognitive-impairment-in-aging-and-early-cerebral-small-vessel-disease
#3
JOURNAL ARTICLE
L A Dobrynina, Z Sh Gadzhieva, O R Dobrushina, S N Morozova, E I Kremneva, A V Volik, M V Krotenkova
OBJECTIVE: To develop individualized approaches to the use of neuromodulation as a non-pharmacological treatment of cognitive impairment (CI) based on the assessment of compensatory brain reserves in functional MRI (fMRI). MATERIAL AND METHODS: Twenty-one adults over 45 years of age, representing a continuum from healthy norm to mild cognitive impairment due to aging and early cerebral small vessel disease, were studied. All participants underwent fMRI while performing two executive tasks - a modified Stroop task and selective counting...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/38526403/psychosocial-impairment-in-older-patients-with-bipolar-i-disorder
#4
JOURNAL ARTICLE
Berkay Vahapoğlu, Cana Aksoy Poyraz, Armağan Özdemir
BACKGROUND: The goal of this study was to assess psychosocial functioning in older patients with bipolar I disorder compared with healthy subjects and to identify the psychopathological factors associated with poor functioning in patients. METHODS: We recruited 68 euthymic patients with bipolar I disorder from the outpatient unit and 89 healthy controls who were older than 50 years of age. In addition to clinical variables, we used other standardized measures, including the Young Mania Rating Scale, the Hamilton Depression Rating Scale, the Hamilton Anxiety Rating Scale, the Functional Assessment Short Test, and the Montreal Cognitive Assessment...
March 1, 2024: Journal of Psychiatric Practice
https://read.qxmd.com/read/38525910/global-cognition-and-executive-functions-of-older-adults-with-type-1-diabetes-mellitus-without-dementia
#5
JOURNAL ARTICLE
Kaoru Nagasawa, Kimio Matsumura, Takayasu Uchida, Yuya Suzuki, Akihiro Nishimura, Minoru Okubo, Yukifusa Igeta, Tetsuro Kobayashi, Takashi Sakurai, Yasumichi Mori
AIMS/INTRODUCTION: This study aimed to characterize the global cognition and executive functions of older adults with type 1 diabetes mellitus in comparison with type 2 diabetes mellitus. MATERIALS AND METHODS: This study included 37 patients with type 1 diabetes mellitus aged ≥65 years and 37 age- and sex-matched patients with type 2 diabetes mellitus. Patients with dementia scoring <24 on the Mini-Mental State Examination were excluded. General cognition, memory, classic, and practical executive function were investigated...
March 25, 2024: Journal of Diabetes Investigation
https://read.qxmd.com/read/38525784/the-frailty-reduction-via-implementation-of-exercise-nutrition-and-deprescribing-friend-trial-study-protocol-and-recruitment-results
#6
JOURNAL ARTICLE
Michael Inskip, Carolina Almendrales Rangel, Chidiamara Maria Njoku, Fiona Barnett, Isabel Shih, Leonie O'Neill, Maria A Fiatarone Singh, Trinidad Valenzuela
INTRODUCTION: Virtually all adults in aged care facilities are frail, a condition which contributes to falls, cognitive decline, hospitalisation, and mortality. Polypharmacy, malnutrition, sedentariness, and sarcopenia are risk factors amenable to intervention. The Asia-Pacific Frailty Management Guidelines recommend anabolic exercise and the optimisation of medications and nutrition. However, no study has evaluated this best practice intervention triad in aged care. METHODS: The Frailty Reduction via the Implementation of Exercise, Nutrition, and Deprescribing (FRIEND) Trial (ANZCTR No...
March 22, 2024: Methods and Protocols
https://read.qxmd.com/read/38525317/risk-factors-for-postoperative-cognitive-decline-after-orthopedic-surgery-in-elderly-chinese-patients-a-retrospective-cohort-study
#7
JOURNAL ARTICLE
Xian Li, Hong Lai, Peng Wang, Shuai Feng, Xuexin Feng, Chao Kong, Dewei Wu, Chunlin Yin, Jianghua Shen, Suying Yan, Rui Han, Jia Liu, Xiaoyi Ren, Ying Li, Lu Tang, Dong Xue, Ying Zhao, Hao Huang, Xiaoying Li, Yanhong Zhang, Xue Wang, Chunxiu Wang, Ping Jin, Shibao Lu, Tianlong Wang, Guoguang Zhao, Chaodong Wang
PURPOSE: We aimed to identify the risk factors for postoperative cognitive decline (POCD) by evaluating the outcomes from preoperative comprehensive geriatric assessment (CGA) and intraoperative anesthetic interventions. PATIENTS AND METHODS: Data used in the study were obtained from the Aged Patient Perioperative Longitudinal Evaluation-Multidisciplinary Trial (APPLE-MDT) cohort recruited from the Department of Orthopedics in Xuanwu Hospital, Capital Medical University between March, 2019 and June, 2022...
2024: Clinical Interventions in Aging
https://read.qxmd.com/read/38522226/serum-lipids-and-cognitive-outcomes-in-multiple-sclerosis-a-systematic-review-and-meta-analysis
#8
REVIEW
Sarvin Sanaie, Narges Koohi, Reza Mosaddeghi-Heris, Shirin Rezai, Elahe Movagharnia, Hanie Karimi, Seyedehyasmin Moghaddamziabari, Sina Hamzehzadeh, Elnaz Gholipour-Khalili, Mahnaz Talebi, Amirreza Naseri
BACKGROUND: Cognitive impairment is highly prevalent in multiple sclerosis (MS) with poorly understood underlying mechanisms. Lipids are considered to be associated with MS progression through the inflammatory and oxidative stress pathways, brain atrophy, cellular signaling, and tissue physiology. In addition, serum lipids are proposed as a modifiable factor affecting the neuropsychiatric condition; therefore, this study aims to assess the association between serum lipid levels and cognitive outcomes in MS...
February 29, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38520638/prediction-model-for-mild-cognitive-impairment-in-patients-with-type-2-diabetes-using-the-autonomic-function-test
#9
JOURNAL ARTICLE
Heeyoung Kang, Juhyeon Kim, Minkyeong Kim, Jin Hyun Kim, Gu Seob Roh, Soo Kyoung Kim
OBJECTIVE: Type 2 diabetes mellitus (T2DM) is a risk factor for cognitive impairment, and reduced heart rate variability (HRV) has been correlated with cognitive impairment in elderly individuals. This study investigated risk factors and validated a predictive model for mild cognitive impairment (MCI) in patients with T2DM using an autonomic function test. METHODS: Patients with T2DM, 50-85 years of age, who attended the diabetes clinic at Gyeongsang National University Hospital between March 2018 and December 2019, were included...
March 23, 2024: Neurological Sciences
https://read.qxmd.com/read/38520603/validity-of-montreal-cognitive-assessment-to-detect-cognitive-impairment-in-individuals-with-type-2-diabetes
#10
JOURNAL ARTICLE
Anu Gupta, Alpesh Goyal, Roopa Rajan, Venugopalan Y Vishnu, Mani Kalaivani, Nikhil Tandon, Madakasira V P Srivastava, Yashdeep Gupta
INTRODUCTION: Guidelines recommend screening older people (> 60-65 years) with type 2 diabetes (T2D) for cognitive impairment, as it has implications in the management of diabetes. The Montreal Cognitive Assessment (MoCA) is a sensitive test for the detection of mild cognitive impairment (MCI) in the general population, but its validity in T2D has not been established. METHODS: We administered MoCA to patients with T2D (age ≥ 60 years) and controls (no T2D), along with a culturally validated neuropsychological battery and functional activity questionnaire...
March 23, 2024: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/38520376/structural-brain-networks-correlating-with-poststroke-cognition
#11
JOURNAL ARTICLE
Sonia L E Brownsett, Leeanne M Carey, David Copland, Alistair Walsh, Aleksi J Sihvonen
Cognitive deficits are a common and debilitating consequence of stroke, yet our understanding of the structural neurobiological biomarkers predicting recovery of cognition after stroke remains limited. In this longitudinal observational study, we set out to investigate the effect of both focal lesions and structural connectivity on poststroke cognition. Sixty-two patients with stroke underwent advanced brain imaging and cognitive assessment, utilizing the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE), at 3-month and 12-month poststroke...
April 2024: Human Brain Mapping
https://read.qxmd.com/read/38518543/mri-index-of-glymphatic-system-mediates-the-influence-of-locus-coeruleus-on-cognition-in-parkinson-s-disease
#12
JOURNAL ARTICLE
Xinhui Wang, Pei Huang, Ewart Mark Haacke, Peng Wu, Xiaobing Zhang, Huihui Zhang, Zenghui Cheng, Rongbiao Tang, Fangtao Liu, Yu Liu, Xiaofeng Shi, Peng Liu, Youmin Zhang, Zhijia Jin, Shengdi Chen, Naying He, Fuhua Yan
INTRODUCTION: Although locus coeruleus (LC) has been demonstrated to play a critical role in the cognitive function of Parkinson's disease (PD), the underlying mechanism has not been elucidated. The objective was to investigate the relationship among LC degeneration, cognitive performance, and the glymphatic function in PD. METHODS: In this retrospective study, 71 PD subjects (21 with normal cognition; 29 with cognitive impairment (PD-MCI); 21 with dementia (PDD)) and 26 healthy controls were included...
March 15, 2024: Parkinsonism & related Disorders
https://read.qxmd.com/read/38512706/comparison-of-nonimmersive-virtual-reality-and-task-oriented-circuit-training-on-gait-balance-and-cognition-among-elderly-population-a-single-blind-randomized-control-trial
#13
JOURNAL ARTICLE
Misbah Ghous, Qudsia Masood, Arshad Nawaz Malik, Ayesha Afridi, Qamar Mehmood
Purpose: The purpose of this study was to determine the effects of nonimmersive virtual reality (VR) and task-oriented circuit training on gait, balance, cognitive domains, and quality of life among the elderly population. Methods: This is a single-blind randomized control trial in which 28 elderly individuals between 60 and 75 years were selected. The participants were divided into two groups, task-oriented circuit training and the other receiving nonimmersive VR treatment, with 14 participants in each group...
March 21, 2024: Games for Health
https://read.qxmd.com/read/38512092/-the-effect-of-insomnia-on-mild-cognitive-impairment-in-patients-with-vascular-risks-results-of-a-three-year-longitudinal-study
#14
JOURNAL ARTICLE
O V Vorob'ova, N N Shindryaeva, V V Fateeva
OBJECTIVE: To assess the dynamics of sleep parameters based on the analysis of three items of HDRS-17, designed to measure the severity of insomnia, during 36 months of follow-up and their relationship with indicators of the cognitive phenotype in patients with vascular risk factors. MATERIAL AND METHODS: The longitudinal study included 51 patients (mean age 57.7±6.2 years, 19 (37.3%) men)) who met the inclusion criteria. All participants underwent a general clinical examination with assessment of vascular risks and neuropsychological testing using the Montreal Cognitive Assessment (MoCA) and HDRS-17 at baseline and after 36 months...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/38512091/-the-relationship-between-the-development-of-post-stroke-cognitive-impairment-and-changes-in-the-coagulation-component-of-hemostasis
#15
JOURNAL ARTICLE
I A Koltsov, I A Shchukin, E A Kovalenko, N S Karpova, Y E Shilov, O S Brusov
OBJECTIVE: To evaluate the relationship between the severity of post-stroke cognitive impairment (PSCI) and coagulation parameters assessed using the dynamic thrombophotometry. MATERIAL AND METHODS: Thirty-five patients with hemispheric ischemic stroke (IS) with moderate neurological deficit at admission were included. All patients underwent a comprehensive clinical and instrumental assessment according to the current guidelines. On days 10-14, the cognitive status of patients was assessed using the Montreal Cognitive Assessment (MoCA)...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/38512025/the-therapeutic-effect-of-buyang-huanwu-decoction-on-mild-cognitive-impairment-mci-in-patients-with-diabetes
#16
JOURNAL ARTICLE
Ximing Cui, Shuang Wang, Shunjiang Xu, Lina Wang, Shanshan Dong, Rui Zhang, Zhaoyu Gao, Lei Jiang, Tingting Shen, Yingying Guo, Huimin Zhou
Objective: This study aims to comprehensively verify the efficacy of Buyang Huanwu Decoction in improving cognitive function in patients with diabetes. Methods: Patients clinically diagnosed with mild cognitive impairment (MCI) assigned to either the placebo group or the Buyang Huanwu Decoction group. After strict screening and exclusions, a total of 156 participants completed the clinical trial, with 76 in the placebo group and 80 in the Buyang Huanwu Decoction group. Results: After treatment, Buyang Huanwu Decoction group showed higher Mini-Mental State Examination and Montreal Cognitive Assessment scores compared to placebo (P < 0...
March 21, 2024: International Journal of Neuroscience
https://read.qxmd.com/read/38511330/influence-of-infarct-morphology-and-patterns-on-cognitive-outcomes-after-endovascular-thrombectomy
#17
JOURNAL ARTICLE
Johanna Maria Ospel, Leon Rinkel, Aravind Ganesh, Andrew Demchuk, Manish Joshi, Alexandre Poppe, Ryan McTaggart, Raul Nogueira, Bijoy Menon, Michael Tymianski, Michael Douglas Hill, Mayank Goyal
BACKGROUND: To assess the association of qualitative and quantitative infarct characteristics and 3 cognitive outcome tests, namely the Montreal Cognitive Assessment (MOCA) for mild cognitive impairment, the Boston Naming Test for visual confrontation naming, and the Sunnybrook Neglect Assessment Procedure for neglect, in large vessel occlusion stroke. METHODS: Secondary observational cohort study using data from the randomized-controlled ESCAPE-NA1 trial (Safety and Efficacy of Nerinetide in Subjects Undergoing Endovascular Thrombectomy for Stroke), in which patients with large vessel occlusion undergoing endovascular treatment were randomized to receive either intravenous Nerinetide or placebo...
March 21, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38508848/frailty-and-cognitive-function-in%C3%A2-middle-aged-and-older-adults-with%C3%A2-congenital-heart-disease
#18
JOURNAL ARTICLE
Bo Daelman, Liesbet Van Bulck, Koen Luyckx, Adrienne H Kovacs, Alexander Van De Bruaene, Magalie Ladouceur, Hsiao-Ling Yang, Ju Ryoung Moon, André Schmidt, Birgitte Lykkeberg, Edward Callus, Michèle de Hosson, Camilla Sandberg, Bengt Johansson, Joanna Hlebowicz, Maria Emília Areias, Pascal Amedro, Louise Coats, Zacharias Mandalenakis, Anna Kaneva, Philip Moons, Eva Goossens
BACKGROUND: Life expectancy of patients with congenital heart disease (CHD) has increased rapidly, resulting in a growing and aging population. Recent studies have shown that older people with CHD have higher morbidity, health care use, and mortality. To maintain longevity and quality of life, understanding their evolving medical and psychosocial challenges is essential. OBJECTIVES: The authors describe the frailty and cognitive profile of middle-aged and older adults with CHD to identify predictor variables and to explore the relationship with hospital admissions and outpatient visits...
March 26, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38507621/listening-effort-an-overview-of-app-validation-and-testing-by-the-audiology-4-all-project
#19
JOURNAL ARTICLE
Luísa Passadouro, Carla Matos Silva, Cláudia Dos Reis, Cristina Nazaré, Sergio Paulo, Margarida Serrano
OBJECTIVE: To describe an application's development and validation process that aims to track hearing difficulties in adverse environments (a listening effort application). DESIGN: 71 subjects were evaluated, divided into two groups: 30 subjects aged between 18 and 30, and 41 subjects aged between 40 and 65. All subjects had European Portuguese as their native language; the Montreal Cognitive Assessment (MOCA) scored above 24, and all could read and write. All subjects performed the intelligibility test in noise and the test of listening effort...
March 18, 2024: International Tinnitus Journal
https://read.qxmd.com/read/38507076/phenotypic-spectrum-of-tinnitus-patients-bearing-rare-ank2-gene-variants
#20
JOURNAL ARTICLE
Juan Martin-Lagos, Alberto Bernal-Robledano, Patricia Perez-Carpena, Mar Lamolda, Alba Escalera-Balsera, Lidia Frejo, Jose A Lopez-Escamez
PURPOSE: To describe the clinical, audiological, and psychometric features observed in patients with chronic tinnitus and rare variants in the ANK2 gene. METHODS: We report a case series of 12 patients with chronic tinnitus and heterozygous variants in the ANK2 gene. Tinnitus phenotyping included audiological (standard and high-frequency audiometry, Auditory Brainstem Responses (ABR) and Auditory Middle Latency Responses (AMLR)), psychoacoustic and psychometric assessment by a Visual Analog Scale (VAS) for tinnitus annoyance, the Tinnitus Handicap Inventory (THI), the test on Hypersensitivity to Sound (THS-GÜF), the Patient Health Questionnaire (PHQ-9), the Hospital Anxiety and Depression Scale (HADS) and the Montreal Cognitive Assessment (MoCA)...
March 20, 2024: European Archives of Oto-rhino-laryngology
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