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Mixed method research

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https://www.readbyqxmd.com/read/29668121/lipofection-of-plasmid-dna-into-human-mast-cell-lines-using-lipid-nanoparticles-generated-by-microfluidic-mixing
#1
Brett A Duguay, Kate Wei-Chen Huang, Marianna Kulka
Mast cells are important immune cells that have significant roles in mediating allergy and asthma. Therefore, studying the molecular mechanisms regulating these and other processes in mast cells is important to elucidate. Methods such as lipofection, transduction, and electroporation are often employed to dissect these mechanisms by disrupting gene expression in mast cell lines. However, as with other leukocytes, human mast cells (HMCs) are often refractory to the delivery of plasmids by lipofection. In this study, we investigated the utility of lipid nanoparticles (LNPs) containing the ionizable cationic lipids 1,2-dioleoyloxy-3-dimethylaminopropane, 1,2-dioleyloxy-3-dimethylaminopropane, or 2,2-dilinoleyl-4-(2-dimethylaminoethyl)-[1,3]-dioxolane for the delivery of plasmid DNA into HMC lines...
April 18, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29666566/-enheduanna-a-manifesto-of-falling-live-brain-computer-cinema-performance-performer-and-audience-participation-cognition-and-emotional-engagement-using-multi-brain-bci-interaction
#2
Polina Zioga, Frank Pollick, Minhua Ma, Paul Chapman, Kristian Stefanov
The fields of neural prosthetic technologies and Brain-Computer Interfaces (BCIs) have witnessed in the past 15 years an unprecedented development, bringing together theories and methods from different scientific fields, digital media, and the arts. More in particular, artists have been amongst the pioneers of the design of relevant applications since their emergence in the 1960s, pushing the boundaries of applications in real-life contexts. With the new research, advancements, and since 2007, the new low-cost commercial-grade wireless devices, there is a new increasing number of computer games, interactive installations, and performances that involve the use of these interfaces, combining scientific, and creative methodologies...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29666139/last-year-of-life-study-cologne-lyol-c-protocol-for-a-cross-sectional-mixed-methods-study-to-examine-care-trajectories-and-transitions-in-the-last-year-of-life-until-death
#3
Julia Strupp, Gloria Hanke, Nicolas Schippel, Holger Pfaff, Ute Karbach, Christian Rietz, Raymond Voltz
INTRODUCTION: The last year of life constitutes a particularly vulnerable phase for patients, involving nearly all health and social care structures. Yet, little scientific evidence is available that provides insight into the trajectories including the number and types of care setting transitions, transitions into palliative care and the dying phase. Only few studies have focused on difficulties associated with having to move between health and social care settings in the last year of life, although patients face a significant risk of adverse events...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29664956/you-pray-to-your-god-a-qualitative-analysis-of-challenges-in-the-provision-of-safe-timely-and-affordable-surgical-care-in-uganda
#4
Katherine Albutt, Rachel R Yorlets, Maria Punchak, Peter Kayima, Didacus B Namanya, Geoffrey A Anderson, Mark G Shrime
BACKGROUND: Five billion people lack access to safe, affordable, and timely surgical and anesthesia care. Significant challenges remain in the provision of surgical care in low-resource settings. Uganda is no exception. METHODS: From September to November 2016, we conducted a mixed-methods countrywide surgical capacity assessment at 17 randomly selected public hospitals in Uganda. Researchers conducted 35 semi-structured interviews with key stakeholders to understand factors related to the provision of surgical care...
2018: PloS One
https://www.readbyqxmd.com/read/29664159/reading-aids-for-adults-with-low-vision
#5
REVIEW
Gianni Virgili, Ruthy Acosta, Sharon A Bentley, Giovanni Giacomelli, Claire Allcock, Jennifer R Evans
BACKGROUND: The purpose of low-vision rehabilitation is to allow people to resume or to continue to perform daily living tasks, with reading being one of the most important. This is achieved by providing appropriate optical devices and special training in the use of residual-vision and low-vision aids, which range from simple optical magnifiers to high-magnification video magnifiers. OBJECTIVES: To assess the effects of different visual reading aids for adults with low vision...
April 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29663829/no-evidence-of-atypical-attentional-disengagement-in-autism-a-study-across-the-spectrum
#6
C Ellie Wilson, David Saldaña
The ability to disengage attention and reengage elsewhere has been proposed as a fundamental deficit in the autism spectrum, potentially disrupting development of higher cognitive domains. Eye-movements were recorded while 16 autism spectrum children of mixed ability, and 18 typically developing age-matched controls, completed the Gap-Overlap paradigm. A significant difference in latency to fixate target was found between Gap and Overlap conditions. A significant interaction with group was due to autism spectrum participants' shorter latencies to fixate target in the Gap condition, but similar group responses in the Overlap condition...
April 1, 2018: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/29663658/understanding-consumers-initial-expectations-of-community-based-residential-mental-health-rehabilitation-in-the-context-of-past-experiences-of-care-a-mixed-methods-pragmatic-grounded-theory-analysis
#7
Stephen Parker, Carla Meurk, Ellie Newman, Clayton Fletcher, Isabella Swinson, Frances Dark
This study explores how consumers expect community-based residential mental health rehabilitation to compare with previous experiences of care. Understanding what consumers hope to receive from mental health services, and listening to their perspectives about what has and has not worked in previous care settings, may illuminate pathways to improved service engagement and outcomes. A mixed-methods research design taking a pragmatic approach to grounded theory guided the analysis of 24 semi-structured interviews with consumers on commencement at three Community Care Units (CCUs) in Australia...
April 16, 2018: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29661072/using-information-communication-technology-to-identify-deficits-in-rural-health-care-a-mixed-methods-evaluation-from-guatemala
#8
Katharina Wahedi, Walter Flores, Claudia Beiersmann, Kayvan Bozorgmehr, Albrecht Jahn
BACKGROUND: In August 2014, the Centre for the Studies of Equity and Governance in Health Systems (CEGSS) in Guatemala launched an online platform, which facilitates complaints about health services via text messages. The aim is to collect, systemise and forward such complaints to relevant institutions, and to create a data pool on perceived deficits of health care in rural Guatemala. OBJECTIVE: To evaluate if the online platform is an accepted, user-friendly and efficient medium to engage citizens in the reporting of health care deficiencies in Guatemala...
2018: Global Health Action
https://www.readbyqxmd.com/read/29660999/a-community-based-approach-to-hiv-prevention-in-rural-guatemala
#9
Victoria Orrego Dunleavy, Elena Chudnovskaya, Jazmyne Vanecia Simmons
BACKGROUND: HIV is one of the primary causes of death in Guatemala, and during the period 2005 to 2013, Guatemala exhibited a 95% increase in such deaths. HIV transmission rates are nearly 3 times higher among the indigenous Mayan population than nonindigenous Guatemalans. Guided by the community-based participatory research approach, this article demonstrates the iterative formative research process necessary to develop a deeper and more informed understanding of HIV prevention attitudes and behaviors in the priority population...
April 1, 2018: Health Promotion Practice
https://www.readbyqxmd.com/read/29660036/effectiveness-of-exercise-therapy-in-the-management-of-wruld-in-sedentary-workers-a-systematic-review
#10
D Kelly, F Shorthouse, V Roffi, C Tack
Background: Work-related upper limb disorders (WRULDs) are a syndrome of symptoms affecting the upper quadrant of the body and are a significant cause of pain, disability and sickness absence among workers. Exercise therapy is considered to be a clinical and cost-effective strategy in WRULD management. Aims: To evaluate the effectiveness of exercise therapy for WRULDs in sedentary workers. Methods: This review follows an a priori protocol to maintain internal validity describing essential procedures to be followed (e...
April 11, 2018: Occupational Medicine
https://www.readbyqxmd.com/read/29659296/mental-health-knowledge-and-training-needs-among-direct-care-workers-a-mixed-methods-study
#11
Candace Konnert, Vivian Huang, Barbara Pesut
OBJECTIVES: Direct care providers (DCWs) spend the most time with clients in the home, and as such, play an integral role in identifying mental health problems. However, DCWs receive little preparation in mental health and there is little research regarding their role in the mental health care of clients. The purpose of this study was to explore DCWs' knowledge, attitudes, and experiences of caring for clients with mental health problems from the perspectives of DCWs and key administrators (KAs)...
April 16, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29650060/gastrostomy-versus-nasogastric-tube-feeding-for-chemoradiation-patients-with-head-and-neck-cancer-the-tube-pilot-rct
#12
Vinidh Paleri, Joanne Patterson, Nikki Rousseau, Eoin Moloney, Dawn Craig, Dimitrios Tzelis, Nina Wilkinson, Jeremy Franks, Ann Marie Hynes, Ben Heaven, David Hamilton, Teresa Guerrero-Urbano, Rachael Donnelly, Stewart Barclay, Tim Rapley, Deborah Stocken
BACKGROUND: Approximately 9000 new cases of head and neck squamous cell cancers (HNSCCs) are treated by the NHS each year. Chemoradiation therapy (CRT) is a commonly used treatment for advanced HNSCC. Approximately 90% of patients undergoing CRT require nutritional support via gastrostomy or nasogastric tube feeding. Long-term dysphagia following CRT is a primary concern for patients. The effect of enteral feeding routes on swallowing function is not well understood, and the two feeding methods have, to date (at the time of writing), not been compared...
April 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29650025/effectiveness-of-health-education-as-an-intervention-designed-to-prevent-female-genital-mutilation-cutting-fgm-c-a-systematic-review
#13
REVIEW
Susan Waigwa, Lucy Doos, Caroline Bradbury-Jones, Julie Taylor
BACKGROUND: Female Genital Mutilation/Cutting (FGM/C) is a harmful practice that violates the human rights of women and girls. Despite global efforts to restrict the practice, there have been few reports on major positive changes to the problem. Health education interventions have been successful in preventing various health conditions and promoting service use. They have also been regarded as promising interventions for preventing FGM/C. The objective of this systematic review is to synthesise findings of studies about effectiveness of health education as an intervention to prevent FGM/C...
April 12, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29649227/from-kitchen-to-classroom-assessing-the-impact-of-cleaner-burning-biomass-fuelled-cookstoves-on-primary-school-attendance-in-karonga-district-northern-malawi
#14
Christine A Kelly, Amelia C Crampin, Kevin Mortimer, Albert Dube, Jullita Malava, Deborah Johnston, Elaine Unterhalter, Judith R Glynn
Household air pollution from burning solid fuels is responsible for an estimated 2.9 million premature deaths worldwide each year and 4.5% of global disability-adjusted life years, while cooking and fuel collection pose a considerable time burden, particularly for women and children. Cleaner burning biomass-fuelled cookstoves have the potential to lower exposure to household air pollution as well as reduce fuelwood demand by increasing the combustion efficiency of cooking fires, which may in turn yield ancillary benefits in other domains...
2018: PloS One
https://www.readbyqxmd.com/read/29648651/is-lean-sustainable-in-today-s-nhs-hospitals-a-systematic-literature-review-using-the-meta-narrative-and-integrative-methods
#15
Samuel Woodnutt
Purpose: Methodological variance and quality, heterogeneity of value and divergent approaches are reasons for the varied results of Lean interventions in healthcare despite ongoing global popularity. However, there is piecemeal evidence addressing the sustainability of initiatives-the aim of this review is to use an integrative approach to consider Lean's sustainability and the quality of available evidence in today's National Health Service (NHS). Data sources: A literature review of AMED, CINAHL, Cochrane, JBI, SCOPUS, DelphiS, MEDLINE, EMBASE, MIDIRS, Web of Science and PsycINFO electronic databases was conducted...
April 10, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29644897/the-feasibility-acceptability-and-preliminary-efficacy-of-a-low-cost-virtual-reality-based-upper-limb-stroke-rehabilitation-device-a-mixed-methods-study
#16
Alyson Warland, Ioannis Paraskevopoulos, Emmanuel Tsekleves, Jennifer Ryan, Alexander Nowicky, Joanne Griscti, Hannah Levings, Cherry Kilbride
PURPOSE: To establish feasibility, acceptability, and preliminary efficacy of an adapted version of a commercially available, virtual-reality gaming system (the Personalised Stroke Therapy system) for upper-limb rehabilitation with community dwelling stroke-survivors. METHOD: Twelve stroke-survivors (nine females, mean age 58 years, [standard deviation 7.1], median stroke chronicity 42 months [interquartile range 34.7], Motricity index 14-25 for shoulder and elbow) were asked to complete nine, 40-min intervention sessions using two activities on the system over 3 weeks...
April 12, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29629235/variable-selection-in-heterogeneous-datasets-a-truncated-rank-sparse-linear-mixed-model-with-applications-to-genome-wide-association-studies
#17
Haohan Wang, Bryon Aragam, Eric P Xing
A fundamental and important challenge in modern datasets of ever increasing dimensionality is variable selection, which has taken on renewed interest recently due to the growth of biological and medical datasets with complex, non-i.i.d. structures. Naïvely applying classical variable selection methods such as the Lasso to such datasets may lead to a large number of false discoveries. Motivated by genome-wide association studies in genetics, we study the problem of variable selection for datasets arising from multiple subpopulations, when this underlying population structure is unknown to the researcher...
November 2017: Proceedings
https://www.readbyqxmd.com/read/29627115/migrant-children-within-europe-a-systematic-review-of-children-s-perspectives-on-their-health-experiences
#18
REVIEW
P Curtis, J Thompson, H Fairbrother
OBJECTIVES: To review the extant literature to explore what is known about children's own perspectives on their health experiences, focussing on children and young people who have migrated into, and within, Europe. STUDY DESIGN: A systematic review with narrative synthesis. METHODS: A review of English language articles was performed in June 2016 using the following databases: MEDLINE, CINAHL, Cochrane and Web of Science. Included articles had to report data generated directly with children, up to 18 years of age, who had migrated across national borders into, or within, Europe during their own lifetimes...
April 4, 2018: Public Health
https://www.readbyqxmd.com/read/29625598/community-readiness-and-momentum-identifying-and-including-community-driven-variables-in-a-mixed-method-rural-palliative-care-service-siting-model
#19
V A Crooks, M Giesbrecht, H Castleden, N Schuurman, M Skinner, A Williams
BACKGROUND: Health service administrators make decisions regarding how to best use limited resources to have the most significant impact. Service siting models are tools that can help in this capacity. Here we build on our own mixed-method service siting model focused on identifying rural Canadian communities most in need of and ready for palliative care service enhancement through incorporating new community-driven insights. METHODS: We conducted 40 semi-structured interviews with formal and informal palliative care providers from four purposefully selected rural communities across Canada...
April 6, 2018: BMC Palliative Care
https://www.readbyqxmd.com/read/29625126/primers-targeting-mitochondrial-genes-of-avian-haemosporidians-pcr-detection-and-differential-dna-amplification-of-parasites-belonging-to-different-genera
#20
M Andreína Pacheco, Axl S Cepeda, Rasa Bernotienė, Ingrid A Lotta, Nubia E Matta, Gediminas Valkiūnas, Ananias A Escalante
Haemosporida is a diverse group of vector-borne parasitic protozoa, ubiquitous in terrestrial vertebrates worldwide. The renewed interest in their diversity has been driven by the extensive use of molecular methods targeting mitochondrial genes. Unfortunately, most studies target a 478 bp fragment of the cytochrome b (cytb) gene, which often cannot be used to separate lineages from different genera found in mixed infections that are common in wildlife. In this investigation, an alignment constructed with 114 mitochondrial genome sequences belonging to four genera (Leucocytozoon, Haemoproteus, Plasmodium and Hepatocystis) was used to design two different sets of primers targeting the cytb gene as well as the other two mitochondrial DNA genes: cytochrome c oxidase subunit 1 and cytochrome c oxidase subunit 3...
April 3, 2018: International Journal for Parasitology
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