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https://www.readbyqxmd.com/read/27903825/synthetic-biology-routes-to-bio-artificial-intelligence
#1
REVIEW
Darren N Nesbeth, Alexey Zaikin, Yasushi Saka, M Carmen Romano, Claudiu V Giuraniuc, Oleg Kanakov, Tetyana Laptyeva
The design of synthetic gene networks (SGNs) has advanced to the extent that novel genetic circuits are now being tested for their ability to recapitulate archetypal learning behaviours first defined in the fields of machine and animal learning. Here, we discuss the biological implementation of a perceptron algorithm for linear classification of input data. An expansion of this biological design that encompasses cellular 'teachers' and 'students' is also examined. We also discuss implementation of Pavlovian associative learning using SGNs and present an example of such a scheme and in silico simulation of its performance...
November 30, 2016: Essays in Biochemistry
https://www.readbyqxmd.com/read/27899567/expansion-of-the-gene-ontology-knowledgebase-and-resources
#2
(no author information available yet)
The Gene Ontology (GO) is a comprehensive resource of computable knowledge regarding the functions of genes and gene products. As such, it is extensively used by the biomedical research community for the analysis of -omics and related data. Our continued focus is on improving the quality and utility of the GO resources, and we welcome and encourage input from researchers in all areas of biology. In this update, we summarize the current contents of the GO knowledgebase, and present several new features and improvements that have been made to the ontology, the annotations and the tools...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27899245/lessons-learned-from-mississippi-s-telehealth-approach-to-health-disparities
#3
REVIEW
Richard D deShazo, Sara Bolen Parker
Many people see telemedicine as a solution to the nation's health disparities and in Mississippi as a solution to our last place in health. Over 13 years ago, the University of Mississippi Medical Center developed a successful TelEmergency program that saved rural Critical Access Hospitals and now provides telehealth services throughout the state. This occurred without acrimony because of partnerships UMMC developed with telecommunications companies, state government, health professions' licensure boards and private donors...
November 26, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27892913/developing-a-successful-master-of-health-administration-student-mentor-mentee-program
#4
Aliya Shaikh, Layla AlTurabi, Daniel J West
A student mentoring program can impact the overall experience in an academic program and establish a strong connection between students. It creates a platform for students to ask specific questions, learn more about the curriculum and professional opportunities, and compare tips on how to approach businesses for career-building positions. Topics such as conducting a residency search, finding an external mentor, and navigating through academic projects are often stressful components of the master of health administration (MHA) curriculum...
January 2016: Health Care Manager
https://www.readbyqxmd.com/read/27881951/neuronal-gene-targets-of-nf-%C3%AE%C2%BAb-and-their-dysregulation-in-alzheimer-s-disease
#5
REVIEW
Wanda M Snow, Benedict C Albensi
Although, better known for its role in inflammation, the transcription factor nuclear factor kappa B (NF-κB) has more recently been implicated in synaptic plasticity, learning, and memory. This has been, in part, to the discovery of its localization not just in glia, cells that are integral to mediating the inflammatory process in the brain, but also neurons. Several effectors of neuronal NF-κB have been identified, including calcium, inflammatory cytokines (i.e., tumor necrosis factor alpha), and the induction of experimental paradigms thought to reflect learning and memory at the cellular level (i...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27874492/an-update-on-ms-nurse-professional-an-ongoing-project-of-the-european-multiple-sclerosis-platform
#6
Anne Winslow
Within the multidisciplinary team required to manage people with multiple sclerosis (MS) effectively, the nurse is the central component of coordinated care and support. A 2009 survey led by the European Multiple Sclerosis Platform, an umbrella organization of national MS associations, identified variance and disparity across Europe in the nursing care of MS patients. This led to development of MS Nurse PROfessional, a continuing medical education-accredited modular online learning program endorsed and approved by leading international nursing and professional groups, and people with MS, as a tool to support the evolving role of the European MS nurse...
December 2016: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/27861869/s100b%C3%A2-%C3%A2-a1-celisa-a-novel-potency-assay-and-screening-tool-for-redifferentiation-stimuli-of-human-articular-chondrocytes
#7
Jose Diaz-Romero, Sibylle Kürsener, Sandro Kohl, Dobrila Nesic
During monolayer expansion, a necessary step in autologous chondrocyte implantation, human articular chondrocytes (HAC) dedifferentiate and lose their capacity to produce stable hyaline cartilage. Determining HAC potency and learning how to trigger their redifferentiation would improve cell-based cartilage regeneration therapies. We previously identified S100B and S100A1 proteins as markers of HAC redifferentiation potential. Here, we aimed to: (i) demonstrate a correlation between S100B + A1-positive HAC in monolayer culture and their neochondrogenesis capacity in pellet culture; (ii) develop an S100B + A1 cell-based ELISA, and (iii) prove that S100B + A1 induction in HAC increases their chondrogenic capacity...
November 11, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27858251/methodological-issues-in-clinical-trials-of-polycystic-kidney-disease-a-focused-review
#8
REVIEW
Ioan-Andrei Iliuta, Abhijat Kitchlu, York Pei
The field of therapeutics in autosomal dominant polycystic kidney disease (ADPKD) has seen a significant expansion recently, as major clinical trials have provided promising evidence in favor of new disease-modifying drugs. Though these trials are encouraging, limitations are noticeable in the form of methodological issues that restrict the interpretation of results. In this review, we discuss the methodological pitfalls of high-profile clinical interventional trials for ADPKD which have been published since 2009...
November 17, 2016: Journal of Nephrology
https://www.readbyqxmd.com/read/27834887/a-review-of-the-growth-of-the-fast-food-industry-in-china-and-its-potential-impact-on-obesity
#9
REVIEW
Youfa Wang, Liang Wang, Hong Xue, Weidong Qu
The fast-food (FF) industry and obesity rates have rapidly increased in China. This study examined the FF industry growth in China, key factors contributing to the growth, and the association between FF consumption (FFC) and obesity. We collected related data from multiple sources and conducted analysis including linear regression analysis on the increase in FF revenue. It was found that FF industry in China is large, with over two million FF facilities. Its total revenue (in million US$) increased from 10,464 in 1999 to 94,218 in 2013, and by 13% annually since 2008...
November 9, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27832518/expanding-the-scope-of-an-automated-radiology-recommendation-tracking-engine-initial-experiences-and-lessons-learned
#10
Mindy Y Licurse, Darco Lalevic, Hanna M Zafar, Mitchell D Schnall, Tessa S Cook
An automated radiology recommendation-tracking engine for incidental focal masses in the liver, pancreas, kidneys, and adrenal glands was launched within our institution in July 2013. For 2 years, the majority of CT, MR, and US examination reports generated within our health system were mined by the engine. However, the need to expand the system beyond the initial four organs was soon identified. In July 2015, the second phase of the system was implemented and expanded to include additional anatomic structures in the abdomen and pelvis, as well as to provide non-radiology and non-imaging options for follow-up...
November 10, 2016: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/27803993/sustaining-and-expanding-evidence-based-supported-employment-the-role-of-state-leaders-participating-in-a-learning-community
#11
Gary R Bond, Annalee V Johnson-Kwochka, Deborah R Becker, Robert E Drake, Mary Ann Greene
State leaders often promote implementation of evidence-based practices but have difficulty sustaining and expanding them over time. This paper examines the activities of leaders in 13 states that have successfully implemented, sustained, and expanded evidence-based supported employment, known as Individual Placement and Support (IPS), for 4 to 12 years. We interviewed state leaders from 13 states participating in a learning community regarding the composition of their leadership team, participation in the learning community, interagency collaboration, state policy alignment, financing, training, and monitoring of fidelity and outcome...
November 1, 2016: Administration and Policy in Mental Health
https://www.readbyqxmd.com/read/27802646/communication-understanding-molecular-representations-in-machine-learning-the-role-of-uniqueness-and-target-similarity
#12
Bing Huang, O Anatole von Lilienfeld
The predictive accuracy of Machine Learning (ML) models of molecular properties depends on the choice of the molecular representation. Inspired by the postulates of quantum mechanics, we introduce a hierarchy of representations which meet uniqueness and target similarity criteria. To systematically control target similarity, we simply rely on interatomic many body expansions, as implemented in universal force-fields, including Bonding, Angular (BA), and higher order terms. Addition of higher order contributions systematically increases similarity to the true potential energy and predictive accuracy of the resulting ML models...
October 28, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27795320/cell-biological-studies-of-osmotic-shock-response-in-streptomyces
#13
Katsuya Fuchino, Klas Flärdh, Paul Dyson, Nora Ausmees
: Most bacteria are likely to face osmotic challenges, but there is yet much to learn about how such environmental changes affects the architecture of bacterial cells. Here we report a cell-biological study in model organisms of the genus Streptomyces, which are Actinobacteria that grow in a highly polarized fashion to form branching hyphae. The characteristic apical growth of Streptomyces hyphae is orchestrated by protein assemblies, called polarisomes, that contain coiled-coil proteins DivIVA and Scy, and recruit cell wall synthesis complexes and the stress-bearing cytoskeleton of FilP to the tip regions of the hyphae...
October 17, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/27783817/concept-maps-in-nursing-education-a-historical-literature-review-and-research-directions
#14
Barbara J Daley, Sarah Morgan, Sarah Beman Black
BACKGROUND: Although concept mapping was created in the early 1980s, research in nursing education first appeared in 1992. This literature review analyzes the impact of concept mapping in nursing education. METHOD: A total of 221 articles, books, and book chapters were reviewed on the topic of concept mapping in nursing education. RESULTS: Results indicate that concept-mapping research progressed from the emergence state, to an expansion and adaptation stage, to an established stage...
November 1, 2016: Journal of Nursing Education
https://www.readbyqxmd.com/read/27783477/expanded-substrate-activity-of-oxa-24-40-in-carbapenem-resistant-acinetobacter-baumannii-involves-enhanced-binding-loop-flexibility
#15
Michael Wesbrook Staude, David A Leonard, Jeffrey W Peng
Gram-negative bacteria resist β-lactam antibiotics primarily by deploying β-lactamase proteins that hydrolytically destroy the antibiotics. In clinical settings, these bacteria are producing variant β-lactamases with "gain of activity" mutations that inactivate a broader range of β-lactams. Learning how these mutations broaden substrate activity is important for coping with β-lactam resistance. Here, we investigate a gain of activity mutation in OXA-24/40, a carbapenem-hydrolyzing Class D β-lactamase (CHDL) in Acinetobacter baumannii...
October 26, 2016: Biochemistry
https://www.readbyqxmd.com/read/27743225/establishing-a-cancer-research-consortium-in-low-and-middle-income-countries-challenges-faced-and-lessons-learned
#16
Sara E Fischer, Olusegun I Alatise, Akinwunmi O Komolafe, Aba I Katung, Adedeji A Egberongbe, Samuel A Olatoke, Olayide S Agodirin, Oladapo A Kolawole, Olaejerinde O Olaofe, Omobolaji O Ayandipo, Olorunda Rotimi, Murray F Brennan, T Peter Kingham
PURPOSE: There is an increasing effort in the global public health community to strengthen research capacity in low- and middle-income countries, but there is no consensus on how best to approach such endeavors. Successful consortia that perform research on HIV/AIDS and other infectious diseases exist, but few papers have been published detailing the challenges faced and lessons learned in setting up and running a successful research consortium. METHODS: Members of the African Research Group for Oncology (ARGO) participated in generating lessons learned regarding the foundation and maintenance of a cancer research consortium in Nigeria...
October 14, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27740584/lessons-learned-from-expansion-of-a-public-health-nursing-doctorate-in-nursing-practice-program
#17
Nathan G Tipton, Patricia M Speck, Trimika L Bowdre, Pamela D Connor
Despite nurses' demonstrated expertise in the public health workforce, there has been a continued erosion of public health nursing (PHN) positions in health departments and academe. The need for a strong public health infrastructure and well-educated public health workforce remains vital in meeting PHN research challenges. In response to these needs, our college of nursing undertook a six-year Health Resources and Services Administration-funded expansion of the PHN Doctor of Nursing Practice (DNP) program. This article illustrates program evaluation, lessons learned, and PHN DNP graduate and workforce outcomes related to supplying culturally diverse PHN leaders, assuring quality improvement, creating sustainable partnerships, and improving poor health outcomes...
July 2016: Nursing Education Perspectives
https://www.readbyqxmd.com/read/27727279/regulatory-t-cell-responses-in-participants-with-type-1-diabetes-after-a-single-dose-of-interleukin-2-a-non-randomised-open-label-adaptive-dose-finding-trial
#18
John A Todd, Marina Evangelou, Antony J Cutler, Marcin L Pekalski, Neil M Walker, Helen E Stevens, Linsey Porter, Deborah J Smyth, Daniel B Rainbow, Ricardo C Ferreira, Laura Esposito, Kara M D Hunter, Kevin Loudon, Kathryn Irons, Jennie H Yang, Charles J M Bell, Helen Schuilenburg, James Heywood, Ben Challis, Sankalpa Neupane, Pamela Clarke, Gillian Coleman, Sarah Dawson, Donna Goymer, Katerina Anselmiova, Jane Kennet, Judy Brown, Sarah L Caddy, Jia Lu, Jane Greatorex, Ian Goodfellow, Chris Wallace, Tim I Tree, Mark Evans, Adrian P Mander, Simon Bond, Linda S Wicker, Frank Waldron-Lynch
BACKGROUND: Interleukin-2 (IL-2) has an essential role in the expansion and function of CD4+ regulatory T cells (Tregs). Tregs reduce tissue damage by limiting the immune response following infection and regulate autoreactive CD4+ effector T cells (Teffs) to prevent autoimmune diseases, such as type 1 diabetes (T1D). Genetic susceptibility to T1D causes alterations in the IL-2 pathway, a finding that supports Tregs as a cellular therapeutic target. Aldesleukin (Proleukin; recombinant human IL-2), which is administered at high doses to activate the immune system in cancer immunotherapy, is now being repositioned to treat inflammatory and autoimmune disorders at lower doses by targeting Tregs...
October 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27714785/behavioral-development-in-embryonic-and-early-juvenile-cuttlefish-sepia-officinalis
#19
Caitlin E O'Brien, Nawel Mezrai, Anne-Sophie Darmaillacq, Ludovic Dickel
Though a mollusc, the cuttlefish Sepia officinalis possesses a sophisticated brain, advanced sensory systems, and a large behavioral repertoire. Cuttlefish provide a unique perspective on animal behavior due to their phylogenic distance from more traditional (vertebrate) models. S. officinalis is well-suited to addressing questions of behavioral ontogeny. As embryos, they can perceive and learn from their environment and experience no direct parental care. A marked progression in learning and behavior is observed during late embryonic and early juvenile development...
October 7, 2016: Developmental Psychobiology
https://www.readbyqxmd.com/read/27713816/cgg-repeat-dynamics-and-fmr1-gene-silencing-in-fragile-x-syndrome-stem-cells-and-stem-cell-derived-neurons
#20
Yifan Zhou, Daman Kumari, Nicholas Sciascia, Karen Usdin
BACKGROUND: Fragile X syndrome (FXS), a common cause of intellectual disability and autism, results from the expansion of a CGG-repeat tract in the 5' untranslated region of the FMR1 gene to >200 repeats. Such expanded alleles, known as full mutation (FM) alleles, are epigenetically silenced in differentiated cells thus resulting in the loss of FMRP, a protein important for learning and memory. The timing of repeat expansion and FMR1 gene silencing is controversial. METHODS: We monitored the repeat size and methylation status of FMR1 alleles with expanded CGG repeats in patient-derived induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) that were grown for extended period of time either as stem cells or differentiated into neurons...
2016: Molecular Autism
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