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https://www.readbyqxmd.com/read/29779546/state-legislative-approach-to-enumerating-behavioral-health-workforce-shortages-lessons-learned-in-new-mexico
#1
Deborah B Altschul, Caroline A Bonham, Martha J Faulkner, Amy W Farnbach Pearson, Jessica Reno, Wayne Lindstrom, Shelley M Alonso-Marsden, Annette Crisanti, Julie G Salvador, Richard Larson
Nationally, the behavioral health workforce is in crisis because of a lack of resources, culturally responsive services, quality clinical supervision, sufficient training in evidence-based practices, and targeted recruitment and retention. Disparities in access to behavioral health care are particularly significant in New Mexico, where 25% of the population live in rural areas, and behavioral health shortages are among the highest in the nation. Additionally, as a Medicaid expansion state, New Mexico providers experience increased demand for services at a time when the state is challenged with limited workforce capacity...
June 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29777493/transgenic-mice-carrying-glud2-as-a-tool-for-studying-the-expressional-and-the-functional-adaptation-of-this-positive-selected-gene-in-human-brain-evolution
#2
Andreas Plaitakis, Dimitra Kotzamani, Zoe Petraki, Maria Delidaki, Vagelis Rinotas, Ioannis Zaganas, Eleni Douni, Kyriaki Sidiropoulou, Cleanthe Spanaki
Human evolution is characterized by brain expansion and up-regulation of genes involved in energy metabolism and synaptic transmission, including the glutamate signaling pathway. Glutamate is the excitatory transmitter of neural circuits sub-serving cognitive functions, with glutamate-modulation of synaptic plasticity being central to learning and memory. GLUD2 is a novel positively-selected human gene involved in glutamatergic transmission and energy metabolism that underwent rapid evolutionary adaptation concomitantly with prefrontal cortex enlargement...
May 18, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29749632/the-stability-paradox-why-expansion-of-women-s-education-has-not-delayed-early-union-formation-or-childbearing-in-latin-america
#3
Albert Esteve, Elizabeth Florez-Paredes
Despite substantial improvements in women's education, the age at which Latin American women marry (cohabit) or become mothers for the first time has barely decreased over the past four decades. We refer to this as the "stability paradox." We examine the relationship between years of schooling and transitions to first union or child, analyzing retrospective information from 50 cohorts of women born between 1940 and 1989 in 12 Latin American countries. Absolute and relative measures of schooling are compared...
May 11, 2018: Studies in Family Planning
https://www.readbyqxmd.com/read/29743496/complex-housing-causes-a-robust-increase-in-dendritic-complexity-and-spine-density-of-medial-prefrontal-cortical-neurons
#4
Archana Ashokan, Jamien Wee Han Lim, Nicholas Hang, Rupshi Mitra
Prelimbic cortex and infralimbic cortex, parts of the ventromedial prefrontal cortex, are critical brain regions for generating a flexible behavioral response to changing environmental contingencies. This includes the role of these brain structures in the extinction of learned fear, decision making and retrieval of remote memories. Dendritic structure of medial prefrontal cortex neurons retains significant structural plasticity in adulthood. This has been mainly demonstrated as dendritic atrophy and loss of dendritic spines due to chronic stress...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29740518/enzynet-enzyme-classification-using-3d-convolutional-neural-networks-on-spatial-representation
#5
Afshine Amidi, Shervine Amidi, Dimitrios Vlachakis, Vasileios Megalooikonomou, Nikos Paragios, Evangelia I Zacharaki
During the past decade, with the significant progress of computational power as well as ever-rising data availability, deep learning techniques became increasingly popular due to their excellent performance on computer vision problems. The size of the Protein Data Bank (PDB) has increased more than 15-fold since 1999, which enabled the expansion of models that aim at predicting enzymatic function via their amino acid composition. Amino acid sequence, however, is less conserved in nature than protein structure and therefore considered a less reliable predictor of protein function...
2018: PeerJ
https://www.readbyqxmd.com/read/29717374/all-in-expansion-of-the-acquisition-of-data-for-outcomes-and-procedure-transfer-adopt-program-to-an-entire-sages-annual-meeting-hands-on-hernia-course
#6
Jonathan Dort, Amber Trickey, John Paige, Erin Schwarz, Tom Cecil, Mark Coleman, Brian Dunkin
BACKGROUND: Continuing professional development (CPD) for the surgeon has been challenging because of a lack of standardized approaches of hands-on courses, resulting in poor post-course outcomes. To remedy this situation, SAGES has introduced the ADOPT program, implementing a standardized, long-term mentoring program as part of its hernia hands-on course. Previous work evaluating the pilot program showed increased adoption of learned procedures as well as increased confidence of the mentored surgeons...
May 1, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29715002/machine-learning-in-computer-aided-synthesis-planning
#7
Connor W Coley, William H Green, Klavs F Jensen
Computer-aided synthesis planning (CASP) is focused on the goal of accelerating the process by which chemists decide how to synthesize small molecule compounds. The ideal CASP program would take a molecular structure as input and output a sorted list of detailed reaction schemes that each connect that target to purchasable starting materials via a series of chemically feasible reaction steps. Early work in this field relied on expert-crafted reaction rules and heuristics to describe possible retrosynthetic disconnections and selectivity rules but suffered from incompleteness, infeasible suggestions, and human bias...
May 1, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29704807/applications-of-low-cost-sensing-technologies-for-air-quality-monitoring-and-exposure-assessment-how-far-have-they-gone
#8
REVIEW
Lidia Morawska, Phong K Thai, Xiaoting Liu, Akwasi Asumadu-Sakyi, Godwin Ayoko, Alena Bartonova, Andrea Bedini, Fahe Chai, Bryce Christensen, Matthew Dunbabin, Jian Gao, Gayle S W Hagler, Rohan Jayaratne, Prashant Kumar, Alexis K H Lau, Peter K K Louie, Mandana Mazaheri, Zhi Ning, Nunzio Motta, Ben Mullins, Md Mahmudur Rahman, Zoran Ristovski, Mahnaz Shafiei, Dian Tjondronegoro, Dane Westerdahl, Ron Williams
Over the past decade, a range of sensor technologies became available on the market, enabling a revolutionary shift in air pollution monitoring and assessment. With their cost of up to three orders of magnitude lower than standard/reference instruments, many avenues for applications have opened up. In particular, broader participation in air quality discussion and utilisation of information on air pollution by communities has become possible. However, many questions have been also asked about the actual benefits of these technologies...
April 25, 2018: Environment International
https://www.readbyqxmd.com/read/29703577/enhancing-parent-talk-reading-and-play-in-primary-care-sustained-impacts-of-the-video-interaction-project
#9
Carolyn Brockmeyer Cates, Adriana Weisleder, Samantha Berkule Johnson, Anne M Seery, Caitlin F Canfield, Harris Huberman, Benard P Dreyer, Alan L Mendelsohn
OBJECTIVE: To determine the early impacts of pediatric primary care parenting interventions on parent cognitive stimulation in low socioeconomic status families and whether these impacts are sustained up to 1.5 years after program completion. STUDY DESIGN: This randomized controlled trial included assignment to 1 of 2 interventions (Video Interaction Project [VIP] or Building Blocks) or to a control group. Mother-newborn dyads were enrolled postpartum in an urban public hospital...
April 24, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29702967/neurosurgery-in-east-africa-innovations
#10
Karol P Budohoski, Japhet G Ngerageza, Benedict Austard, Anthony Fuller, Robert Galler, Michael Haglund, Ronald Lett, Isador H Lieberman, Halinder S Mangat, Karen March, David Olouch-Olunya, José Piquer, Mahmood Qureshi, Maria M Santos, Karsten Schöller, Hamisi K Shabani, Rikin A Trivedi, Paul Young, Micaella R Zubkov, Roger Härtl, Philip E Stieg
In the last 10 years, considerable work has been done to promote and improve neurosurgical care in East Africa with the development of national training programs, expansion of hospitals and creation of new institutions, and the foundation of epidemiologic and cost-effectiveness research. Many of the results have been accomplished through collaboration with partners from abroad. This article is the third in a series of articles that seek to provide readers with an understanding of the development of neurosurgery in East Africa (Foundations), the challenges that arise in providing neurosurgical care in developing countries (Challenges), and an overview of traditional and novel approaches to overcoming these challenges to improve healthcare in the region (Innovations)...
May 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29688643/-fmr1-premutation-carriers-are-they-really-asymptomatic
#11
REVIEW
Shai Elizur, Michal Berkenstadt, Liat Ries-Levavi, Noah Gruber, Orit Pinhas-Hamiel, Sharon Hassin-Baer, Annick Raas-Rothschild, Hila Raanani, Tali Cukierman-Yaffe, Raoul Orvieto, Yoram Cohen, Lidia Gabis
Fragile X Syndrome (FXS), the most common form of inherited mental retardation, is caused by a trinucleotide repeat expansion (CGG) in the 5'-untranslated region of the Fragile X Mental Retardation 1 (FMR1) gene located at Xq27.3. Patients with fragile X -related mental retardation, carry the full mutation CGG-repeat expansions (>200 CGG repeats), which are generally accompanied by hypermethylation of the promoter region, with the consequent transcriptional silencing of the FMR1 gene and absence of the encoded FMR1 protein (FMRP)...
April 2018: Harefuah
https://www.readbyqxmd.com/read/29683038/the-recruitment-of-new-members-to-existing-pbsgl-small-groups-a-qualitative-study
#12
Julia Park, David E Cunningham
Introduction Practice-Based Small Group Learning (PBSGL) is a learning programme widely adopted by primary healthcare professions (general practitioners, general practice nurses and pharmacists) in Scotland and other countries in the UK. PBSGL groups recruit members and decide on meeting dates and venues. Study aims To determine how groups recruit new members and discern what are the important attributes of the new members. Method A grounded theory approach was used with purposive sampling to recruit PBSGL groups to the study...
April 23, 2018: Education for Primary Care
https://www.readbyqxmd.com/read/29671203/the-policy-driven-hiv-epidemic-among-opioid-users-in-the-russian-federation
#13
REVIEW
Robert Heimer
PURPOSE OF REVIEW: To explore the consequences of policies implemented in the Russian Federation in response to syndemic of HIV-1 and opioid use disorder and compare the responses to the concomitant syndemic in rural America. RECENT FINDINGS: The syndemic spread has not been reduced by policies implemented by the Russian government, which continues to underfund harm reduction efforts to reduce HIV transmission, refuses to approve evidence-based opioid agonist treatments for opioid use disorder, and relies on criminal justice and abstinence approaches to control illicit opioids...
April 18, 2018: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/29669746/learning-dependent-and-independent-enhancement-of-mitral-tufted-cell-glomerular-odor-responses-following-olfactory-fear-conditioning-in-awake-mice
#14
Jordan M Ross, Max L Fletcher
Associative fear learning produces fear toward the conditioned stimulus (CS) and often generalization, the expansion of fear from the CS to similar, unlearned stimuli. However, how fear learning affects early sensory processing of learned and unlearned stimuli in relation to behavioral fear responses to these stimuli remains unclear. We subjected male and female mice expressing the fluorescent calcium indicator GCaMP3 in olfactory bulb mitral and tufted cells to a classical olfactory fear conditioning paradigm...
April 18, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29622381/harnessing-the-private-health-sector-by-using-prices-as-a-policy-instrument-lessons-learned-from-south-africa
#15
Sarah L Barber, Ankit Kumar, Tomas Roubal, Francesca Colombo, Luca Lorenzoni
Governments frequently draw upon the private health care sector to promote sustainability, optimal use of resources, and increased choice. In doing so, policy-makers face the challenge of harnessing resources while grappling with the market failures and equity concerns associated with private financing of health care. The growth of the private health sector in South Africa has fundamentally changed the structure of health care delivery. A mutually reinforcing ecosystem of private health insurers, private hospitals and specialists has grown to account for almost half of the country's spending on health care, despite only serving 16% of the population with the capacity to pay...
March 29, 2018: Health Policy
https://www.readbyqxmd.com/read/29606954/automatic-mri-quantifying-methods-in-behavioral-variant-frontotemporal-dementia-diagnosis
#16
Antti Cajanus, Anette Hall, Juha Koikkalainen, Eino Solje, Antti Tolonen, Timo Urhemaa, Yawu Liu, Ramona M Haanpää, Päivi Hartikainen, Seppo Helisalmi, Ville Korhonen, Daniel Rueckert, Steen Hasselbalch, Gunhild Waldemar, Patrizia Mecocci, Ritva Vanninen, Mark van Gils, Hilkka Soininen, Jyrki Lötjönen, Anne M Remes
Aims: We assessed the value of automated MRI quantification methods in the differential diagnosis of behavioral-variant frontotemporal dementia (bvFTD) from Alzheimer disease (AD), Lewy body dementia (LBD), and subjective memory complaints (SMC). We also examined the role of the C9ORF72 -related genetic status in the differentiation sensitivity. Methods: The MRI scans of 50 patients with bvFTD (17 C9ORF72 expansion carriers) were analyzed using 6 quantification methods as follows: voxel-based morphometry (VBM), tensor-based morphometry, volumetry (VOL), manifold learning, grading, and white-matter hyperintensities...
January 2018: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/29594204/infrastructure-and-distributed-learning-methodology-for-privacy-preserving-multi-centric-rapid-learning-health-care-eurocat
#17
Timo M Deist, A Jochems, Johan van Soest, Georgi Nalbantov, Cary Oberije, Seán Walsh, Michael Eble, Paul Bulens, Philippe Coucke, Wim Dries, Andre Dekker, Philippe Lambin
Machine learning applications for personalized medicine are highly dependent on access to sufficient data. For personalized radiation oncology, datasets representing the variation in the entire cancer patient population need to be acquired and used to learn prediction models. Ethical and legal boundaries to ensure data privacy hamper collaboration between research institutes. We hypothesize that data sharing is possible without identifiable patient data leaving the radiation clinics and that building machine learning applications on distributed datasets is feasible...
June 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29580581/acute-kidney-injury-and-progression-of-diabetic-kidney-disease
#18
REVIEW
Samuel Mon-Wei Yu, Joseph V Bonventre
Diabetic kidney disease, commonly termed diabetic nephropathy (DN), is the most common cause of end-stage kidney disease (ESKD) worldwide. The characteristic histopathology of DN includes glomerular basement membrane thickening, mesangial expansion, nodular glomerular sclerosis, and tubulointerstitial fibrosis. Diabetes is associated with a number of metabolic derangements, such as reactive oxygen species overproduction, hypoxic state, mitochondrial dysfunction, and inflammation. In the past few decades, our knowledge of DN has advanced considerably although much needs to be learned...
March 2018: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/29559291/deep-learning-algorithm-for-auto-delineation-of-high-risk-oropharyngeal-clinical-target-volumes-with-built-in-dice-similarity-coefficient-parameter-optimization-function
#19
Carlos E Cardenas, Rachel E McCarroll, Laurence E Court, Baher A Elgohari, Hesham Elhalawani, Clifton D Fuller, Mona J Kamal, Mohamed A M Meheissen, Abdallah S R Mohamed, Arvind Rao, Bowman Williams, Andrew Wong, Jinzhong Yang, Michalis Aristophanous
PURPOSE: Automating and standardizing the contouring of clinical target volumes (CTVs) can reduce interphysician variability, which is one of the largest sources of uncertainty in head and neck radiation therapy. In addition to using uniform margin expansions to auto-delineate high-risk CTVs, very little work has been performed to provide patient- and disease-specific high-risk CTVs. The aim of the present study was to develop a deep neural network for the auto-delineation of high-risk CTVs...
February 7, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29553728/chemical-pressure-driven-enhancement-of-the-hydrogen-evolving-activity-of-ni-2-p-from-nonmetal-surface-doping-interpreted-via-machine-learning
#20
Robert B Wexler, John Mark P Martirez, Andrew M Rappe
The activity of Ni2 P catalysts for the hydrogen evolution reaction (HER) is currently limited by strong H adsorption at the Ni3 -hollow site. We investigate the effect of surface nonmetal doping on the HER activity of the Ni3 P2 termination of Ni2 P(0001), which is stable at modest electrochemical conditions. Using density functional theory (DFT) calculations, we find that both 2 p nonmetals and heavier chalcogens provide nearly thermoneutral H adsorption at moderate surface doping concentrations. We also find, however, that only chalcogen substitution for surface P is exergonic...
April 4, 2018: Journal of the American Chemical Society
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