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https://www.readbyqxmd.com/read/28919148/creation-and-dissemination-of-a-multispecialty-gme-curriculum-in-pediatric-and-adolescent-gynecology-the-naspag-resident-education-committee-experiences
#1
Carol Wheeler, K J Browner-Elhanan, Yolanda Evans, Nathalie Fleming, Patricia S Huguelet, Nicole W Karjane, Meredith Loveless, Hina J Talib, Paritosh Kaul
OBJECTIVE: The goal was to develop a multispecialty committee to address deficiencies in pediatric and adolescent gynecology resident education through curricular development under the auspices of the North American Society for Pediatric and Adolescent Gynecology. DESIGN: A multispecialty North American committee was organized to develop both short and long curricula in pediatric and adolescent gynecology (PAG) through a combination of conference calls and face-to-face meetings...
September 14, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28911111/combinatorial-ensemble-mirna-target-prediction-of-co-regulation-networks-with-non-prediction-data
#2
Jason A Davis, Sita J Saunders, Martin Mann, Rolf Backofen
MicroRNAs (miRNAs) are key regulators of cell-fate decisions in development and disease with a vast array of target interactions that can be investigated using computational approaches. For this study, we developed metaMIR, a combinatorial approach to identify miRNAs that co-regulate identified subsets of genes from a user-supplied list. We based metaMIR predictions on an improved dataset of human miRNA-target interactions, compiled using a machine-learning-based meta-analysis of established algorithms. Simultaneously, the inverse dataset of negative interactions not likely to occur was extracted to increase classifier performance, as measured using an expansive set of experimentally validated interactions from a variety of sources...
September 6, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28879148/implementation-of-broad-screening-with-ebola-rapid-diagnostic-tests-in-for%C3%A3-cariah-guinea
#3
Frantz Jean Louis, Jennifer Y Huang, Yacouba K Nebie, Lamine Koivogui, Gayatri Jayaraman, Nadine Abiola, Amanda Vansteelandt, Mary C Worrel, Judith Shang, Louise B Murphy, David L Fitter, Barbara J Marston, Lise Martel
BACKGROUND: Laboratory-enhanced surveillance is critical for rapidly detecting the potential re-emergence of Ebola virus disease. Rapid diagnostic tests (RDT) for Ebola antigens could expand diagnostic capacity for Ebola virus disease. OBJECTIVES: The Guinean National Coordination for Ebola Response conducted a pilot implementation to determine the feasibility of broad screening of patients and corpses with the OraQuick(®) Ebola RDT. METHODS: The implementation team developed protocols and trained healthcare workers to screen patients and corpses in Forécariah prefecture, Guinea, from 15 October to 30 November 2015...
2017: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/28878789/effect-of-co-segregating-markers-on-high-density-genetic-maps-and-prediction-of-map-expansion-using-machine-learning-algorithms
#4
Amidou N'Diaye, Jemanesh K Haile, D Brian Fowler, Karim Ammar, Curtis J Pozniak
Advances in sequencing and genotyping methods have enable cost-effective production of high throughput single nucleotide polymorphism (SNP) markers, making them the choice for linkage mapping. As a result, many laboratories have developed high-throughput SNP assays and built high-density genetic maps. However, the number of markers may, by orders of magnitude, exceed the resolution of recombination for a given population size so that only a minority of markers can accurately be ordered. Another issue attached to the so-called 'large p, small n' problem is that high-density genetic maps inevitably result in many markers clustering at the same position (co-segregating markers)...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28876444/innovative-use-of-service-learning-to-enhance-baccalaureate-nursing-education
#5
Wanda Taylor, Rosanne Pruitt, Tracy Fasolino
BACKGROUND: Service-learning is an established pedagogical approach to nursing education found primarily in community nursing. With changing health care landscapes, the expansion of service-learning projects throughout the nursing program provides opportunities to enrich assessment and critical thinking and amplify exposure to determinants of health. METHOD: Implementing service-learning in foundational nursing courses allows students to be challenged with the application of complex care management within a context of caring, cultural competence, social responsibility, and self-care initiatives...
September 1, 2017: Journal of Nursing Education
https://www.readbyqxmd.com/read/28866562/visualizing-dataflow-graphs-of-deep-learning-models-in-tensorflow
#6
Kanit Wongsuphasawat, Daniel Smilkov, James Wexler, Jimbo Wilson, Dandelion Mane, Doug Fritz, Dilip Krishnan, Fernanda B Viegas, Martin Wattenberg
We present a design study of the TensorFlow Graph Visualizer, part of the TensorFlow machine intelligence platform. This tool helps users understand complex machine learning architectures by visualizing their underlying dataflow graphs. The tool works by applying a series of graph transformations that enable standard layout techniques to produce a legible interactive diagram. To declutter the graph, we decouple non-critical nodes from the layout. To provide an overview, we build a clustered graph using the hierarchical structure annotated in the source code...
August 29, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28865474/barriers-and-facilitators-to-implementation-of-va-home-based-primary-care-on-american-indian-reservations-a-qualitative-multi-case-study
#7
B Josea Kramer, Sarah D Cote, Diane I Lee, Beth Creekmur, Debra Saliba
BACKGROUND: Veterans Health Affairs (VA) home-based primary care (HBPC) is an evidence-based interdisciplinary approach to non-institutional long-term care that was developed in urban settings to provide longitudinal care for vulnerable older patients. Under the authority of a Memorandum of Understanding between VA and Indian Health Service (IHS) to improve access to healthcare, 14 VA medical centers (VAMC) independently initiated plans to expand HBPC programs to rural American Indian reservations and 12 VAMC successfully implemented programs...
September 2, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28862111/how-can-we-improve-education-of-breast-surgeons-across-europe
#8
Agnieszka Kolacinska
The proposed global curriculum developed by the American Society of Surgical Oncology (SSO) and the European Society of Surgical Oncology (ESSO) and the textbook: provides a state-of- the- art of breast cancer surgery, complements the syllabus and curriculum of the Union Europeenne des Medecins Specialistes (UEMS) examination in breast surgery/ European Board of Surgery Qualification in Breast Surgery (EBSQinBS) administered by ESSO (1) Knowledge and understanding of the principles of breast cancer incidence, aetiology, risk factors, genetics, premalignant and high-risk lesions, pathology, prognostic and predictive factors, risk prediction models, screening, diagnosis and imaging, breast cancer, oncoplastic, reconstructive breast surgery, axillary surgery and future perspective for this, radiation therapy, neoadjuvant and adjuvant systemic treatment- endocrine-, immuno- and chemotherapy, side effects and toxicities of treatment, locoregional recurrence, follow-up, locally advanced breast cancer, metastatic breast cancer, breast cancer in young and elderly patients, survivor issues, lymphedema, palliative care, chroni pain, body image and sexuality, fertility issues, cognitive functions, etc...
July 2017: Chirurgia
https://www.readbyqxmd.com/read/28858786/a-functional-regression-approach-to-facial-landmark-tracking
#9
Enrique Sanchez-Lozano, Georgios Tzimiropoulos, Brais Martinez, Fernando De la Torre, Michel Valstar
Linear regression is a fundamental building block in many face detection and tracking algorithms, typically used to predict shape displacements from image features through a linear mapping. This paper presents a Functional Regression solution to the least squares problem, which we coin Continuous Regression, resulting in the first real-time incremental face tracker. Contrary to prior work in Functional Regression, in which B-splines or Fourier series were used, we propose to approximate the input space by its first-order Taylor expansion, yielding a closed-form solution for the continuous domain of displacements...
August 29, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28856040/relaynet-retinal-layer-and-fluid-segmentation-of-macular-optical-coherence-tomography-using-fully-convolutional-networks
#10
Abhijit Guha Roy, Sailesh Conjeti, Sri Phani Krishna Karri, Debdoot Sheet, Amin Katouzian, Christian Wachinger, Nassir Navab
Optical coherence tomography (OCT) is used for non-invasive diagnosis of diabetic macular edema assessing the retinal layers. In this paper, we propose a new fully convolutional deep architecture, termed ReLayNet, for end-to-end segmentation of retinal layers and fluid masses in eye OCT scans. ReLayNet uses a contracting path of convolutional blocks (encoders) to learn a hierarchy of contextual features, followed by an expansive path of convolutional blocks (decoders) for semantic segmentation. ReLayNet is trained to optimize a joint loss function comprising of weighted logistic regression and Dice overlap loss...
August 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28835490/asymptomatic-primary-infection-with-epstein-barr-virus-observations-on-young-adult-cases
#11
Rachel J Abbott, Annette Pachnio, Isabela Pedroza-Pacheco, Alison M Leese, Jusnara Begum, Heather M Long, Debbie Croom-Carter, Andrea Stacey, Paul A H Moss, Andrew D Hislop, Persephone Borrow, Alan B Rickinson, Andrew I Bell
Epstein-Barr virus (EBV) is typically acquired asymptomatically in childhood. By contrast, infection later in life often leads to infectious mononucleosis (IM), a febrile illness characterised by anti-EBV IgM antibody-positivity, high loads of circulating latently-infected B cells, and a marked lymphocytosis caused by hyper-expansion of EBV-specific CD8(+) T cells plus milder expansion of CD56(dim) NKG2A(+) KIR(-) NK cells. How the two situations compare is unclear due to the paucity of studies on clinically-silent infection...
August 23, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28829283/fragile-x-mental-retardation-1-knockout-zebrafish-shows-precocious-development-in-social-behavior
#12
Yao-Ju Wu, Mao-Ting Hsu, Ming-Chong Ng, Tamara G Amstislavskaya, Maria A Tikhonova, Yi-Ling Yang, Kwok-Tung Lu
Fragile X syndrome (FXS) is a generally hereditary form of human mental retardation that is caused by triplet repeat expansion (CGG) mutation in fragile X mental retardation 1 (fmr1) gene promoter and that results in the absence of the fragile X mental retardation protein (FMRP) expression. The common symptoms of FXS patients include learning disabilities, anxiety, autistic behaviors, as well as other behavioral abnormalities. Our previous results demonstrated the behavioral abnormalities in fmr1 knockout (KO) zebrafish such as fear memory impairment and autism-like behavior...
August 22, 2017: Zebrafish
https://www.readbyqxmd.com/read/28819513/strengthening-and-expanding-the-capacity-of-health-worker-education-in-zambia
#13
Charles Michelo, Joseph Mumba Zulu, Moses Simuyemba, Benjamin Andrews, Max Katubulushi, Benjamin Chi, Evariste Njelesani, Bellington Vwalika, Kasonde Bowa, Margaret Maimbolwa, James Chipeta, Fastone Goma, Selestine Nzala, Sekelani Banda, John Mudenda, Yusuf Ahmed, Lotti Hachambwa, Craig Wilson, Sten Vermund, Yakub Mulla
INTRODUCTION: Zambia is facing a chronic shortage of health care workers. The paper aimed at understanding how the Medical Education Partnership Initiative (MEPI) program facilitated strengthening and expanding of the national capacity and quality of medical education as well as processes for retaining faculty in Zambia. METHODS: Data generated through documentary review, key informant interviews and observations were analyzed using a thematic approach. RESULTS: The MEPI program triggered the development of new postgraduate programs thereby increasing student enrollment...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28818679/improved-assays-for-agg-interruptions-in-fragile-x-premutation-carriers
#14
Bruce E Hayward, Karen Usdin
The learning disability fragile X syndrome results from the presence of >200 CGG/CCG-repeats in exon 1 of the X-linked gene FMR1. Such alleles arise by expansion from maternally transmitted FMR1 premutation alleles, alleles having 55 to 200 repeats. Expansion risk is directly related to maternal repeat number. However, AGG interruptions to the repeat tract are important modifiers of expansion risk. Thus, the ability to identify such interruptions is crucial for the appropriate genetic counseling of women who are premutation carriers...
August 14, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28816655/gaussian-process-morphable-models
#15
Marcel Luthi, Thomas Gerig, Christoph Jud, Thomas Vetter
Models of shape variations have become a central component for the automated analysis of images. An important class of shape models are point distribution models (PDMs). These models represent a class of shapes as a normal distribution of point variations, whose parameters are estimated from example shapes. Principal component analysis (PCA) is applied to obtain a low-dimensional representation of the shape variation in terms of the leading principal components. In this paper, we propose a generalization of PDMs, which we refer to as Gaussian Process Morphable Models (GPMMs)...
August 14, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28815538/long-noncoding-rnas-in-the-yeast-s-%C3%A2-cerevisiae
#16
Rachel O Niederer, Evan P Hass, David C Zappulla
Long noncoding RNAs have recently been discovered to comprise a sizeable fraction of the RNA World. The scope of their functions, physical organization, and disease relevance remain in the early stages of characterization. Although many thousands of lncRNA transcripts recently have been found to emanate from the expansive DNA between protein-coding genes in animals, there are also hundreds that have been found in simple eukaryotes. Furthermore, lncRNAs have been found in the bacterial and archaeal branches of the tree of life, suggesting they are ubiquitous...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28814542/fragile-x-newborn-screening-lessons-learned-from-a-multisite-screening-study
#17
MULTICENTER STUDY
Donald B Bailey, Elizabeth Berry-Kravis, Louise W Gane, Sonia Guarda, Randi Hagerman, Cynthia M Powell, Flora Tassone, Anne Wheeler
BACKGROUND: Delays in the diagnosis of children with fragile X syndrome (FXS) suggest the possibility of newborn screening as a way to identify children earlier. However, FXS does not have a proven treatment that must be provided early, and ethical concerns have been raised about the detection of infants who are carriers. This article summarizes major findings from a multisite, prospective, longitudinal pilot screening study. METHODS: Investigators in North Carolina, California, and Illinois collaborated on a study in which voluntary screening for FXS was offered to parents in 3 birthing hospitals...
June 2017: Pediatrics
https://www.readbyqxmd.com/read/28792263/implementing-and-evaluating-a-community-based-inter-institutional-interprofessional-education-pilot-programme
#18
Chante Stubbs, Mavis N Schorn, Jacinta P Leavell, Elena Wong Espiritu, Gerald Davis, Chad K Gentry, Elisa Friedman, Traci Patton, Ali Graham, Ron Crowder, Consuelo H Wilkins
Many health professions programmes have begun integrating interprofessional learning into their curricula; however, community-based interprofessional education (IPE) initiatives are relatively scarce. The Meharry-Vanderbilt Alliance IPE Faculty Collaborative, comprised of faculty from five institutions, developed a community-based IPE programme that allowed students to engage in meaningful interprofessional activities while exposing them to social determinants of health. Thirty students from ten professions were divided into six teams and paired with three community organisations...
August 9, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/28789555/a-machine-learning-approach-to-graph-theoretical-cluster-expansions-of-the-energy-of-adsorbate-layers
#19
Emanuele Vignola, Stephan N Steinmann, Bart D Vandegehuchte, Daniel Curulla, Michail Stamatakis, Philippe Sautet
The accurate description of the energy of adsorbate layers is crucial for the understanding of chemistry at interfaces. For heterogeneous catalysis, not only the interaction of the adsorbate with the surface but also the adsorbate-adsorbate lateral interactions significantly affect the activation energies of reactions. Modeling the interactions of the adsorbates with the catalyst surface and with each other can be efficiently achieved in the cluster expansion Hamiltonian formalism, which has recently been implemented in a graph-theoretical kinetic Monte Carlo (kMC) scheme to describe multi-dentate species...
August 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28781375/the-agricultural-origins-of-time-preference
#20
Oded Galor, Ömer Özak
This research explores the origins of observed differences in time preference across countries and regions. Exploiting a natural experiment associated with the expansion of suitable crops for cultivation in the course of the Columbian Exchange, the research establishes that pre-industrial agro-climatic characteristics that were conducive to higher return to agricultural investment, triggered selection, adaptation and learning processes that generated a persistent positive effect on the prevalence of long-term orientation in the contemporary era...
October 2016: American Economic Review
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