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https://www.readbyqxmd.com/read/28646097/highly-suggestive-preliminary-evidence-that-the-renal-interstitium-contracts-in%C3%A2-vivo
#1
Omar Flores-Sandoval, María Eugenia Sánchez-Briones, Juan F López-Rodríguez, Miriam Z Calvo-Turrubiartes, Lilia Llamazares-Azuara, Manuel Rodríguez-Martínez
To learn more about controlling renal interstitial hydrostatic pressure (RIHP), we assessed its response to renal medullary direct interstitial volume expansion (rmDIVE = 100 μL bolus infusion/30 sec). Three experimental series (S) were performed in hydropenic, anesthetized, right-nephrectomized, acute left renal-denervated and renal perfusion pressure-controlled rats randomly assigned to groups in each S. S1: Rats without hormonal clamp were contrasted before and after rmDIVE induced via 0.9% saline solution bolus (SS group) or 2% albumin in SS bolus (2% ALB + SS group)...
June 2017: Physiological Reports
https://www.readbyqxmd.com/read/28620025/growing-functions-of-the-escrt-machinery-in-cell-biology-and-viral-replication
#2
REVIEW
Edward J Scourfield, Juan Martin-Serrano
The vast expansion in recent years of the cellular processes promoted by the endosomal sorting complex required for transport (ESCRT) machinery has reinforced its identity as a modular system that uses multiple adaptors to recruit the core membrane remodelling activity at different intracellular sites and facilitate membrane scission. Functional connections to processes such as the aurora B-dependent abscission checkpoint also highlight the importance of the spatiotemporal regulation of the ESCRT machinery...
June 15, 2017: Biochemical Society Transactions
https://www.readbyqxmd.com/read/28602636/extensive-phenotyping-of-two-arx-polyalanine-expansion-mutation-mouse-models-that-span-clinical-spectrum-of-intellectual-disability-and-epilepsy
#3
Matilda R Jackson, Kristie Lee, Tessa Mattiske, Emily J Jaehne, Ezgi Ozturk, Bernhard T Baune, Terence J O'Brien, Nigel Jones, Cheryl Shoubridge
The Aristaless-related homeobox gene (ARX) is a known intellectual disability (ID) gene that frequently presents with X-linked infantile spasm syndrome as a comorbidity. ID with epilepsy in children is a chronic and devastating disorder that has poor treatment options and disease outcomes. To gain a better understanding of the role that mutations in ARX play in ID and epilepsy, we investigate ARX patient mutations modelled in mice. Over half of all ARX mutations result from expansions of the first two polyalanine (PA1 and PA2 respectively) tracts...
June 8, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28597295/evolution-of-intrinsic-disorder-in-eukaryotic-proteins
#4
REVIEW
Joseph B Ahrens, Janelle Nunez-Castilla, Jessica Siltberg-Liberles
Conformational flexibility conferred though regions of intrinsic structural disorder allows proteins to behave as dynamic molecules. While it is well-known that intrinsically disordered regions can undergo disorder-to-order transitions in real-time as part of their function, we also are beginning to learn more about the dynamics of disorder-to-order transitions along evolutionary time-scales. Intrinsically disordered regions endow proteins with functional promiscuity, which is further enhanced by the ability of some of these regions to undergo real-time disorder-to-order transitions...
June 8, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28583143/fatigue-mitigation-with-sleeptracktxt2-in-air-medical-emergency-care-systems-study-protocol-for-a-randomized-controlled-trial
#5
P Daniel Patterson, Charity G Moore, Frank X Guyette, Jack M Doman, Denisse Sequeira, Howard A Werman, Doug Swanson, David Hostler, Joshua Lynch, Lindsey Russo, Linda Hines, Karen Swecker, Michael S Runyon, Daniel J Buysse
BACKGROUND: Most air medical Emergency Medical Services (EMS) clinicians work extended duration shifts, and more than 50% report inadequate sleep, poor sleep quality, and/or poor recovery between shifts. The SleepTrackTXT pilot trial (ClinicalTrials.gov, NCT02063737) showed that use of mobile phone text messages could impact EMS clinician self-reported fatigue and sleepiness during long duration shifts. The purpose of the SleepTrackTXT2 trial is to leverage lessons learned from the first SleepTrackTXT study and test an enhanced intervention targeting air medical EMS clinicians...
June 5, 2017: Trials
https://www.readbyqxmd.com/read/28576298/intracellular-trafficking-pathways-of-cx43-gap-junction-channels
#6
Irina Epifantseva, Robin Shaw
Gap Junction (GJ) channels, including the most common Connexin 43 (Cx43), have fundamental roles in excitable tissues by facilitating rapid transmission of action potentials between adjacent cells. For instance, synchronization during each heartbeat is regulated by these ion channels at the cardiomyocyte cell-cell border. Cx43 protein has a short half-life, and rapid synthesis and timely delivery of those proteins to particular subdomains are crucial for the cellular organization of gap junctions and maintenance of intracellular coupling...
May 30, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28575176/global-oncofertility-index-data-gap-slows-progress
#7
Saskia F de Roo, Alexandra S Rashedi, Catharina C M Beerendonk, Antoinette Anazodo, Anne Marie de Man, Willianne L D M Nelen, Teresa K Woodruff
The number of pediatric and young adult cancer survivors is increasing globally due to earlier diagnostics and expansion of targeted chemo- and biologic-based therapeutics. As a consequence, cancer-related infertility and reproductive hormone loss is of increasing concern for both male and female survivors. We attempted to estimate the reproductive loss in oncofertility-practicing countries and to develop a global oncofertility index (OFI). This would allow an accounting of the level of urgency of the issue and would provide national comparisons of fertility loss, which differ based on the prevalence and/or diagnosis frequency and treatment variables by countries or region...
May 30, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28554088/vowels-in-infant-directed-speech-more-breathy-and-more-variable-but-not-clearer
#8
Kouki Miyazawa, Takahito Shinya, Andrew Martin, Hideaki Kikuchi, Reiko Mazuka
Infant-directed speech (IDS) is known to differ from adult-directed speech (ADS) in a number of ways, and it has often been argued that some of these IDS properties facilitate infants' acquisition of language. An influential study in support of this view is Kuhl et al. (1997), which found that vowels in IDS are produced with expanded first and second formants (F1/F2) on average, indicating that the vowels are acoustically further apart in IDS than in ADS. These results have been interpreted to mean that the way vowels are produced in IDS makes infants' task of learning vowel categories easier...
May 26, 2017: Cognition
https://www.readbyqxmd.com/read/28530254/palatal-surgery-in-a-transoral-robotic-setting-tors-preliminary-results-of-a-retrospective-comparison-between-uvulopalatopharyngoplasty-uppp-expansion-sphincter-pharyngoplasty-esp-and-barbed-repositioning-pharyngoplasty-brp
#9
G Cammaroto, F Montevecchi, G D'Agostino, E Zeccardo, C Bellini, G Meccariello, C Vicini
It has become increasingly clear in the past decade that surgical management of obstructive sleep apnoea hypopnoea syndrome (OSAHS) is most successfully managed with multilevel surgery. We evaluated the outcomes of multilevel interventions comparing three different palatal techniques added to TORS: uvulopalatopharyngoplasty (UPPP), a modified expansion sphincter pharyngoplasty (ESP), inspired by the Pang expansion sphincter pharyngoplasty technique and the latest barbed repositioning pharyngoplasty (BRP). Thirty patients were retrospectively evaluated...
May 22, 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28515505/application-of-the-layered-learning-practice-model-in-an-academic-medical-center
#10
Brittany M Loy, Sendra Yang, Jason M Moss, Debra W Kemp, Jamie N Brown
The layered learning practice model (LLPM) is a teaching strategy designed to train residents to precept students and other residents with the oversight of a seasoned clinical pharmacist. This model serves as a tool for residency programs to implement quality precepting opportunities and learning experiences as they look for new ways to integrate multiple learners into the practice setting. The levels of the LLPM include a senior preceptor, resident, and student. It is best implemented through utilization of 4 steps: orientation to the LLPM, preexperience planning, implementation, and postexperience evaluation...
April 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28514238/the-influence-of-maternal-pragmatics-on-the-language-skills-of-children-with-autism
#11
Yael S Stern, Nell Maltman, Megan Y Roberts
OBJECTIVE: This study examined the relationship between mothers' pragmatics and child language in autism spectrum disorder (ASD) and non-ASD language delay (LD) mother-child dyads. METHODS: Participants consisted of 20 dyads of mothers and their toddlers aged 24 to 48 months, with ASD (n = 10) or non-ASD LD (n = 10). Groups were matched on child chronological age, language, and cognition. Maternal pragmatic language was qualified based on the degree of pragmatic violations during a semistructured interview, and was examined in relation to both child language, as measured by the Preschool Language Scale-4 and maternal use of language facilitation strategies during play...
June 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28512343/the-influence-of-statistical-properties-of-fourier-coefficients-on-random-gaussian-surfaces
#12
C P de Castro, M Luković, R F S Andrade, H J Herrmann
Many examples of natural systems can be described by random Gaussian surfaces. Much can be learned by analyzing the Fourier expansion of the surfaces, from which it is possible to determine the corresponding Hurst exponent and consequently establish the presence of scale invariance. We show that this symmetry is not affected by the distribution of the modulus of the Fourier coefficients. Furthermore, we investigate the role of the Fourier phases of random surfaces. In particular, we show how the surface is affected by a non-uniform distribution of phases...
May 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28494330/new-models-to-support-the-professional-education-of-health-visitors-a-qualitative-study-of-the-role-of-space-and-place-in-creating-community-of-learning-hubs
#13
Sara Donetto, Mary Malone, Lynn Sayer, Glenn Robert
BACKGROUND: In response to a policy-driven workforce expansion in England new models of preparing health visitors for practice have been implemented. 'Community of Learning hubs' (COLHs) are one such model, involving different possible approaches to student support in clinical practice placements (for example, 'long arm mentoring' or 'action learning set' sessions). Such models present opportunities for studying the possible effects of spatiality on the learning experiences of students and newly qualified health visitors, and on team relationships more broadly...
April 30, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28470159/-development-and-effects-of-a-children-s-sex-education-program-for-the-parents-of-lower-elementary-grade-students
#14
Eun Mi Lee, Hyunlye Kim
PURPOSE: This study was done to develop a children's sex education program for the parents of lower elementary grade students and to evaluate its effects on sexual knowledge, gender role attitude, parent efficacy for child's sex education, and marital consistency. METHODS: A quasi-experimental with a non-equivalent control group pretest-posttest design was used. The participants were 29 couples (58 parents, experimental group=28, control group=30) from G city. The 5-week (5-session) program was developed based on 'A theory of protection: parents as sex educators' and used the case-based small group learning method...
April 2017: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/28465370/phase-i-dose-escalation-study-of-ramucirumab-in-chinese-patients-with-advanced-solid-tumors
#15
Junning Cao, Dongmei Ji, Zhiyu Chen, Weina Shen, Jin Wang, Baoyue Li, Haidong Chi, Amanda Long, Ling Gao, Jin Li
LESSONS LEARNED: Ramucirumab was well tolerated in Chinese patients with advanced solid tumors, and adverse events were manageable in this study.Pharmacokinetics characteristics in Chinese patients were similar to those in other populations. Immunogenicity was not detected.No efficacy conclusion could be drawn, and further randomized studies are warranted. BACKGROUND: This single-arm, nonrandomized, open-label, dose-escalation, phase I study was designed to evaluate the safety, tolerability, and pharmacokinetics (PK) of ramucirumab in Chinese patients with advanced solid tumors that were resistant to standard therapy or no standard therapy was available...
June 2017: Oncologist
https://www.readbyqxmd.com/read/28463189/basis-expansions-approaches-for-regularized-sequential-dictionary-learning-algorithms-with-enforced-sparsity-for-fmri-data-analysis
#16
Abd-Krim Seghouane, Asif Iqbal
Sequential dictionary learning algorithms have been successfully applied to functional magnetic resonance imaging (fMRI) data analysis. fMRI datasets are however structured data matrices with notions of temporal smoothness in the column direction. This prior information which can be converted to a constraint of smoothness on the learned dictionary atoms has seldomly been included in classical dictionary learning algorithms when applied to fMRI data analysis. In this paper we tackle this problem by proposing two new sequential dictionary learning algorithms dedicated to fMRI data analysis by accounting for this prior information...
April 28, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28456829/the-evolution-of-a-pediatric-ventricular-assist-device-program-the-boston-children-s-hospital-experience
#17
Beth Hawkins, Francis Fynn-Thompson, Kevin P Daly, Michelle Corf, Elizabeth Blume, Jean Connor, Courtney Porter, Christopher Almond, Christina VanderPluym
Mechanical circulatory support in the form of ventricular assist devices (VADs) in children has undergone rapid growth in the last decade. With expansion of device options available for larger children and adolescents, the field of outpatient VAD support has flourished, with many programs unprepared for the clinical, programmatic, and administrative responsibilities. From preimplantation VAD evaluation and patient education to postimplant VAD management, the VAD program, staffed with an interdisciplinary team, is essential to providing safe, effective, and sustainable care for a new technology in an exceedingly complex patient population...
April 29, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28438215/predicting-liver-sbrt-eligibility-and-plan-quality-for-vmat-and-4%C3%AF-plans
#18
Angelia Tran, Kaley Woods, Dan Nguyen, Victoria Y Yu, Tianye Niu, Minsong Cao, Percy Lee, Ke Sheng
BACKGROUND: It is useful to predict planned dosimetry and determine the eligibility of a liver cancer patient for SBRT treatment using knowledge based planning (KBP). We compare the predictive accuracy using the overlap volume histogram (OVH) and statistical voxel dose learning (SVDL) KBP prediction models for coplanar VMAT to non-coplanar 4π radiotherapy plans. METHODS: In this study, 21 liver SBRT cases were selected, which were initially treated using coplanar VMAT plans...
April 24, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28421176/distributed-learning-revitalizing-anesthesiology-training-in-resource-limited-ethiopia
#19
Krupa B Patel, Morgan Dooley, Ananya Abate, Vanessa Moll
BACKGROUND: Ethiopia has a significant paucity of available health-care workers. Despite the increasing number of medical schools, there are not enough physician instructors. Furthermore, availability and standardization of postgraduate training are lacking. Modalities of e-learning have been shown to be successful when used to impart medical education in other resource-limited countries. The Emory University and Addis Ababa University (AAU) Departments of Anesthesiology have formed a collaboration with the intent of improving the AAU Anesthesiology residency program, one of two postgraduate training programs for anesthesiology in Ethiopia...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28388221/exploiting-linkage-information-and-problem-specific-knowledge-in-evolutionary-distribution-network-expansion-planning
#20
Ngoc Hoang Luong, Han La Poutré, Peter A N Bosman
This article tackles the Distribution Network Expansion Planning (DNEP) problemthat has to be solved by distribution network operators to decide which, where, and/or when enhancements to electricity networks should be introduced to satisfy the future power demands. Because of many real-world details involved, the structure of the problem is not exploited easily using mathematical programming techniques, for which reason we consider solving this problem with evolutionary algorithms (EAs). We compare three types of EAs for optimizing expansion plans: the classic genetic algorithm (GA), the estimation-of-distribution algorithm (EDA), and the Gene-pool Optimal Mixing Evolutionary Algorithm (GOMEA)...
April 7, 2017: Evolutionary Computation
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