Sameer Sharif, Jasmine Kang, Behnam Sadeghirad, Fayyaz Rizvi, Ben Forestell, Alisha Greer, Mark Hewitt, Shannon M Fernando, Sangeeta Mehta, Mohamed Eltorki, Reed Siemieniuk, Mark Duffett, Maala Bhatt, Lisa Burry, Jeffrey J Perry, Andrew Petrosoniak, Pratik Pandharipande, Michelle Welsford, Bram Rochwerg
BACKGROUND: We aimed to evaluate the comparative effectiveness and safety of various i.v. pharmacologic agents used for procedural sedation and analgesia (PSA) in the emergency department (ED) and ICU. We performed a systematic review and network meta-analysis to enable direct and indirect comparisons between available medications. METHODS: We searched Medline, EMBASE, Cochrane, and PubMed from inception to 2 March 2023 for RCTs comparing two or more procedural sedation and analgesia medications in all patients (adults and children >30 days of age) requiring emergent procedures in the ED or ICU...
March 2024: British Journal of Anaesthesia