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https://www.readbyqxmd.com/read/28350572/aripiprazole-lauroxil-pharmacokinetic-profile-of-this-long-acting-injectable-antipsychotic-in-persons-with-schizophrenia
#1
Marjie L Hard, Richard J Mills, Brian M Sadler, Ryan Z Turncliff, Leslie Citrome
BACKGROUND: Aripiprazole lauroxil is an extended-release prodrug of aripiprazole for intramuscular injection, approved for schizophrenia treatment. We developed a population pharmacokinetic (PopPK) model to characterize aripiprazole lauroxil PK and evaluate dosing scenarios likely to be encountered in clinical practice. METHODS: Data from 616 patients with schizophrenia, collected from 5 clinical studies, were used to construct the PopPK model. The model was subsequently used to evaluate various dose levels and frequency and the impact of dosing delay on aripiprazole concentrations...
March 27, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28350510/a-qualitative-study-of-a-maintenance-support-program-for-women-at-risk-of-homelessness-part-3-societal-factors
#2
Rose McMaster, Violeta Lopez, Rachel Kornhaber, Michelle Cleary
Homelessness is a collective societal problem, and people who are homeless are often treated as society's underclass, stigmatised and excluded. These issues are often exacerbated among homeless people from countries other than the one in which they are currently living. In this paper we report findings from a qualitative study of homeless women, case managers and health professionals from a Maintenance Support Program and their personal accounts and insights into their experiences of the program. This paper presents the third and last sub-theme "societal factors" of the study where the overarching theme was "A life-changing event: I have the power to change...
March 28, 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28350483/a-qualitative-study-of-a-maintenance-support-program-for-women-at-risk-of-homelessness-part-1-personal-factors
#3
Rose McMaster, Violeta Lopez, Rachel Kornhaber, Michelle Cleary
In this article, a qualitative study of homeless women and their experiences attending a Maintenance Support Programme (MSP) is discussed. The overarching theme that emerged from the study of women in the MSP was 'A life-changing event: I have the power to change'. The article focuses on the first of the sub-themes: personal factors including: (a) health status, (b) beliefs and attitudes, (c) knowledge, and (d) life and interpersonal skills. Findings demonstrate the influence that these factors have on the capacity of homeless women to change their lives...
March 28, 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28350481/a-qualitative-study-of-a-maintenance-support-program-for-women-at-risk-of-homelessness-part-2-situational-factors
#4
Rose McMaster, Violeta Lopez, Rachel Kornhaber, Michelle Cleary
People who are homeless tend to have a number of complex needs. A housing maintenance support program (MSP) for women from the perspectives of clients, case managers and health professionals within the program was explored in this qualitative descriptive study. Interviews were conducted, and data were analysed using thematic analysis. The overarching theme that emerged from the data was "A life-changing event: I have the power to change." This theme was supported by three sub-themes: personal, situational and societal dimensions...
March 28, 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28346696/do-people-trust-dentists-development-of-the-dentist-trust-scale
#5
Jason M Armfield, Manon Ketting, Sergio Chrisopoulos, Sarah R Baker
BACKGROUND: This study aimed to adapt a measure of trust in physicians generally to trust in dentists and to assess the reliability and validity of the measure. METHODS: Questionnaire data were collected from a simple random sample of 596 Australian adults. The 11-item General Trust in Physicians Scale (Hall et al., 2002) was modified to apply to dentists. RESULTS: The Dentist Trust Scale (DTS) had good internal consistency (Cronbach's alpha = 0...
March 27, 2017: Australian Dental Journal
https://www.readbyqxmd.com/read/28346539/is-there-a-relation-between-novelty-seeking-striatal-dopamine-release-and-frontal-cortical-thickness
#6
Natalia Jaworska, Sylvia M Cox, Kevin F Casey, Isabelle Boileau, Mariya Cherkasova, Kevin Larcher, Alain Dagher, Chawki Benkelfat, Marco Leyton
BACKGROUND: Novelty-seeking (NS) and impulsive personality traits have been proposed to reflect an interplay between fronto-cortical and limbic systems, including the limbic striatum (LS). Although neuroimaging studies have provided some evidence for this, most are comprised of small samples and many report surprisingly large effects given the challenges of trying to relate a snapshot of brain function or structure to an entity as complex as personality. The current work tested a priori hypotheses about associations between striatal dopamine (DA) release, cortical thickness (CT), and NS in a large sample of healthy adults...
2017: PloS One
https://www.readbyqxmd.com/read/28346113/wisdom-in-context
#7
Igor Grossmann
Philosophers and psychological scientists have converged on the idea that wisdom involves certain aspects of thinking (e.g., intellectual humility, recognition of uncertainty and change), enabling application of knowledge to life challenges. Empirical evidence indicates that people's ability to think wisely varies dramatically across experiential contexts that they encounter over the life span. Moreover, wise thinking varies from one situation to another, with self-focused contexts inhibiting wise thinking...
March 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/28345979/assessment-and-treatment-options-for-patients-with-constipation
#8
Alison Bardsley
Constipation is a common complaint for people of all ages, with prevalence increasing with age and during pregnancy. Women are more likely to be affected than men. Severity of constipation varies from person to person; most people experience short periods of constipation during their lives, including possibly after surgery, while others have constipation as a chronic long-term condition that can significantly affect their quality of life. There are a number of factors that can contribute to developing constipation including diets low in fibre, changes in lifestyle, side effects of certain medications and low fluid intake...
March 23, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28345941/the-roles-of-negative-affect-and-goal-adjustment-capacities-in-breast-cancer-survivors-associations-with-physical-activity-and-diurnal-cortisol-secretion
#9
Andree L Castonguay, Carsten Wrosch, Catherine M Sabiston
OBJECTIVE: This study examined whether within-person changes of breast cancer survivors' high-arousal negative affect (e.g., feeling scared, upset, anxious, or guilty) could predict high levels of diurnal cortisol secretion and moderate-to-vigorous physical activity (MVPA). In addition, goal adjustment capacities (goal disengagement and goal reengagement) were expected to buffer the effect of negative affect on cortisol and to increase its effect on MVPA. METHOD: High-arousal negative affect, self-reported MVPA, area-under-the-curve of diurnal cortisol secretion, and goal adjustment capacities were assessed in a longitudinal sample of 145 female breast cancer survivors...
April 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28345601/towards-reproducible-mrm-based-biomarker-discovery-using-dried-blood-spots
#10
Sureyya Ozcan, Jason D Cooper, Santiago G Lago, Diarmuid Kenny, Nitin Rustogi, Pawel Stocki, Sabine Bahn
There is an increasing interest in the use of dried blood spot (DBS) sampling and multiple reaction monitoring in proteomics. Although several groups have explored the utility of DBS by focusing on protein detection, the reproducibility of the approach and whether it can be used for biomarker discovery in high throughput studies is yet to be determined. We assessed the reproducibility of multiplexed targeted protein measurements in DBS compared to serum. Eighty-two medium to high abundance proteins were monitored in a number of technical and biological replicates...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28345574/differential-cataract-blindness-by-sex-in-india-evidence-from-two-large-national-surveys
#11
Hira B Pant, Souvik Bandyopadhyay, Neena John, Anil Chandran, Murthy Venkata S Gudlavalleti
AIMS: Women suffer disproportionately more from cataract blindness compared to males in low- and middle-income countries. Two large population-based surveys have been undertaken in India at an interval of 7 years and data from these surveys provided an opportunity to assess the trends in gender differentials in cataract blindness. MATERIALS AND METHODS: Data were extracted from the surveys to discern sex differences in cataract blindness. Multivariate analysis was performed to adjust for confounders and their impact on gender differences in cataract blindness...
February 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28345281/correlates-of-alcohol-consumption-on-heavy-drinking-occasions-of-young-risky-drinkers-event-versus-personal-characteristics
#12
P Dietze, P A Agius, M Livingston, S Callinan, R Jenkinson, M S C Lim, C J C Wright, R Room
AIMS: Risky single occasion drinking (RSOD) by young people is a serious public health issue, yet little is known about the specific circumstances of risky drinking occasions. This study examined the independent effects of event- and individual-specific variables on RSOD. DESIGN: Longitudinal cohort study measuring self-reported RSOD and event- and individual-specific variables across two drinking occasions approximately one year apart. SETTING: Metropolitan Melbourne, Australia...
March 26, 2017: Addiction
https://www.readbyqxmd.com/read/28344449/the-effects-of-3-weeks-of-uphill-and-downhill-walking-on-blood-lipids-and-glucose-metabolism-in-pre-diabetic-men-a-pilot-study
#13
Marc Philippe, Hannes Gatterer, Erika Maria Eder, Alexander Dzien, Matthias Somavilla, Andreas Melmer, Christoph Ebenbichler, Tom Müller, Martin Burtscher
The prevention of type 2 diabetes in persons at risk for diabetes is of utmost importance. Physical activity in general and even exercises at moderate intensities such as walking significantly reduce the risk of the development of type 2 diabetes. However, it is still a matter of debate whether lipids and glucose metabolism are differently affected by regular concentric (e.g., uphill walking) and eccentric (e.g., downhill walking) endurance exercise. The aim of this study was to investigate the effects of short-term (3 weeks) uphill and downhill walking on glucose metabolism and blood lipids in pre-diabetic middle-aged men in a real world setting...
March 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28343269/neophobia-is-negatively-related-to-reversal-learning-ability-in-females-of-a-generalist-bird-of-prey-the-chimango-caracara-milvago-chimango
#14
Jorgelina María Guido, Laura Marina Biondi, Aldo Ivan Vasallo, Rubén Nestor Muzio
In an ever-changing environment, the ability to adapt choices to new conditions is essential for daily living and ultimately, for survival. Behavioural flexibility allows animals to maximise survival and reproduction in novel settings by adjusting their behaviour based on specific information and feedback acquired in their current environments. However, a growing body of evidence indicates that an individual's personality type can limit the extent to which the individual might behave flexibly, by influencing the way an individual pays attention to novelty and how much information it collects and stores, which in turn affects the individual's decision-making and learning process...
March 25, 2017: Animal Cognition
https://www.readbyqxmd.com/read/28342898/temperature-induces-significant-changes-in-both-glycolytic-reserve-and-mitochondrial-spare-respiratory-capacity-in-colorectal-cancer-cell-lines
#15
Mihail I Mitov, Jennifer W Harris, Michael C Alstott, Yekaterina Y Zaytseva, B Mark Evers, D Allan Butterfield
Thermotherapy, as a method of treating cancer, has recently attracted considerable attention from basic and clinical investigators. A number of studies and clinical trials have shown that thermotherapy can be successfully used as a therapeutic approach for various cancers. However, the effects of temperature on cancer bioenergetics have not been studied in detail with a real time, in a microplate, label-free detection approach. This study investigate how changes in temperature affect the bioenergetics characteristics (mitochondrial function and glycolysis) of three colorectal cancer (CRC) cell lines utilizing the Seahorse XF96 technology...
March 22, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28342535/-professional-stressors-and-common-mental-health-disorders-causal-links
#16
C Nicolas, N Chawky, C Jourdan-Ionescu, M-S Drouin, C Page, N Houlfort, G Beauchamp, M Séguin
According to the World Health Organization, depression has become the leading cause of disability in the world, contributing significantly to the burden of health issues especially in the industrialized countries. This is a major public health problem, with potential impact on work climates, productivity at work and the continued existence of the organizations. Some recent studies have examined potential links between professional factors and common mental health disorders, but none have demonstrated a direct causal link...
March 22, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28342450/scientific-feuds-polemics-and-ad-hominem-arguments-in-basic-and-special-interest-genetics
#17
Elof Axel Carlson
Scientific disputes are commonly presented and settled in journal publications. Most are resolved by a weighing of evidence and new findings. In some cases the arguments are personal and in the form of ad hominem attacks on the personality or integrity of an author of a journal article. Many famous scientists (e.g., Galileo, Newton, and Hooke) used ad hominem arguments in responding to their critics. William Bateson, W.F.R. Weldon, William Castle, and H.J. Muller used ad hominem arguments in their publications until the end of World War I, when editorial policy of journals changed...
January 2017: Mutation Research
https://www.readbyqxmd.com/read/28342288/the-role-of-acute-and-chronic-respiratory-colonization-and-infections-in-the-pathogenesis-of-copd
#18
REVIEW
Janice M Leung, Pei Yee Tiew, Micheál Mac Aogáin, Kurtis F Budden, Valerie Fei Lee Yong, Sangeeta S Thomas, Kevin Pethe, Philip M Hansbro, Sanjay H Chotirmall
COPD is a major global concern, increasingly so in the context of ageing populations. The role of infections in disease pathogenesis and progression is known to be important, yet the mechanisms involved remain to be fully elucidated. While COPD pathogens such as Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pneumoniae are strongly associated with acute exacerbations of COPD (AECOPD), the clinical relevance of these pathogens in stable COPD patients remains unclear. Immune responses in stable and colonized COPD patients are comparable to those detected in AECOPD, supporting a role for chronic colonization in COPD pathogenesis through perpetuation of deleterious immune responses...
March 25, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28342226/psychopathology-and-personality-traits-associated-with-driving-while-intoxicated-in-beijing-china-implications-for-interventions
#19
Rong-Jiang Zhao, Wei Sun, Li-Li Zhang, Yan-Ping Bao, Liang Huang, Ping Dong, Shuang-Jiang Zhou, Zhi-Qing Wang, Thomas R Kosten, Hong-Qiang Sun
BACKGROUND AND OBJECTIVES: Driving while intoxicated (DWI) represents an area of grave concern in China, yet little research has focused on it or on the personality traits and psychiatric disorders among these drivers. METHODS: We enrolled 325 of 382 residents charged with DWI in a compulsory detention center in Beijing, China. And 351 male drivers who had never had any alcohol arrests as control participants. All were screened for Axis I disorders using the Chinese version of the Structured Clinical Interview for the Diagnostic Statistical Manual of Mental Disorders IV-TR (SCID), the Minnesota Multiphasic Personality Inventory (MMPI-2), and the Sixteen Personality Factor Questionnaire (16PF)...
March 24, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28341198/cholesterol-levels-are-associated-with-30-day-mortality-from-ischemic-stroke-in-dialysis-patients
#20
I-Kuan Wang, Chung-Hsiang Liu, Tzung-Hai Yen, Jiann-Shing Jeng, Shih-Pin Hsu, Chih-Hung Chen, Li-Ming Lien, Ruey-Tay Lin, An-Chih Chen, Huey-Juan Lin, Hsin-Yi Chi, Ta-Chang Lai, Yu Sun, Siu-Pak Lee, Sheng-Feng Sung, Po-Lin Chen, Jiunn-Tay Lee, Tsuey-Ru Chiang, Shinn-Kuang Lin, Chih-Hsin Muo, Henry Ma, Chi-Pang Wen, Fung-Chang Sung, Chung Y Hsu
BACKGROUND: We investigated the impact of serum cholesterol levels on 30-day mortality after ischemic stroke in dialysis patients. METHODS: From the Taiwan Stroke Registry data, we identified 46,770 ischemic stroke cases, including 1101 dialysis patients and 45,669 nondialysis patients from 2006 to 2013. RESULTS: Overall, the 30-day mortality was 1.46-fold greater in the dialysis group than in the nondialysis group (1.75 versus 1.20 per 1000 person-days)...
March 21, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
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