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https://www.readbyqxmd.com/read/29690841/-cavitary-pulmonary-disease-differential-diagnosis-and-diagnosic-work-up
#1
Lilly Meyer, Andrea Schück, Urs Bürgi, Lars C Huber
No abstract text is available yet for this article.
April 2018: Praxis
https://www.readbyqxmd.com/read/29690603/proximity-induced-artefacts-in-magnetic-imaging-with-nitrogen-vacancy-ensembles-in-diamond
#2
Jean-Philippe Tetienne, David A Broadway, Scott E Lillie, Nikolai Dontschuk, Tokuyuki Teraji, Liam T Hall, Alastair Stacey, David A Simpson, Lloyd C L Hollenberg
Magnetic imaging with ensembles of nitrogen-vacancy (NV) centres in diamond is a recently developed technique that allows for quantitative vector field mapping. Here we uncover a source of artefacts in the measured magnetic field in situations where the magnetic sample is placed in close proximity (a few tens of nm) to the NV sensing layer. Using magnetic nanoparticles as a test sample, we find that the measured field deviates significantly from the calculated field, in shape, amplitude and even in sign. By modelling the full measurement process, we show that these discrepancies are caused by the limited measurement range of NV sensors combined with the finite spatial resolution of the optical readout...
April 23, 2018: Sensors
https://www.readbyqxmd.com/read/29689404/extended-length-of-stay-in-elderly-patients-after-anterior-cervical-discectomy-and-fusion-is-not-attributable-to-baseline-illness-severity-or-post-operative-complications
#3
Owoicho Adogwa, Daniel T Lilly, Victoria D Vuong, Shyam A Desai, Bichun Ouyang, Syed Khalid, Ryan Khanna, Carlos A Bagley, Joseph Cheng
BACKGROUND: Healthcare systems are increasing efforts to minimize postoperative hospital stays to improve resource use. Common explanations for extended postoperative stay are baseline patient sickness, postoperative complications, or physician practice differences. However, the degree extended length of stay (LOS) represents patient illness or postoperative complications remains unknown. The aim is to investigate the influence of postoperative complications and elderly patient comorbidities on extended LOS after anterior cervical discectomy and fusion (ACDF)...
April 21, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29689170/curriculum-based-handwriting-programs-a-systematic-review-with-effect-sizes
#4
Courtney Engel, Kristin Lillie, Sarah Zurawski, Brittany G Travers
Challenges with handwriting can have a negative impact on academic performance, and these challenges are commonly addressed by occupational therapy practitioners in school settings. This systematic review examined the efficacy of curriculum-based interventions to address children's handwriting difficulties in the classroom (preschool to second grade). We reviewed and computed effect sizes for 13 studies (11 Level II, 2 Level III) identified through a comprehensive database search. The evidence shows that curriculum-based handwriting interventions resulted in small- to medium-sized improvements in legibility, a commonly reported challenge in this age group...
May 2018: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/29680881/baricitinib-in-patients-with-rheumatoid-arthritis-and-an-inadequate-response-to-conventional-disease-modifying-antirheumatic-drugs-in-united-states-and-rest-of-world-a-subset-analysis
#5
Alvin F Wells, Maria Greenwald, John D Bradley, Jahangir Alam, Vipin Arora, Cynthia E Kartman
INTRODUCTION: This article evaluates the efficacy and safety of baricitinib 4 mg versus placebo in United States including Puerto Rico (US) and rest of the world (ROW) subpopulations using data pooled from RA-BEAM and RA-BUILD, which enrolled patients with moderate-to-severe adult-onset rheumatoid arthritis (RA). METHODS: In RA-BEAM, patients with an inadequate response (IR) to methotrexate, at least one X-ray erosion, and high sensitivity C-reactive protein (hsCRP) ≥ 6 mg/L were randomized to placebo or orally administered baricitinib 4 mg daily or subcutaneously administered adalimumab 40 mg every other week...
April 21, 2018: Rheumatology and Therapy
https://www.readbyqxmd.com/read/29677321/probing-the-temporal-dynamics-of-the-exploration-exploitation-dilemma-of-eye-movements
#6
Benedikt V Ehinger, Lilli Kaufhold, Peter König
When scanning a visual scene, we are in a constant decision process regarding whether to further exploit the information content at the current fixation or to go on and explore the scene. The balance of these two processes determines the distribution of fixation durations. Using a gaze-contingent paradigm, we experimentally interrupt this process to probe its state. Here, we developed a guided-viewing task where only a single 3° aperture of an image ("bubble") is displayed. Subjects had to fixate the bubble for an experimentally controlled time (forced fixation time)...
March 1, 2018: Journal of Vision
https://www.readbyqxmd.com/read/29676936/pediatric-metabolic-outcome-comparisons-based-on-a-spectrum-of-obesity-and-asthmatic-symptoms
#7
Ashley D Perdue, Lesley A Cottrell, Christa L Lilly, William A Gower, Brian A Ely, Brad Foringer, Melvin L Wright, William A Neal
RATIONALE: Asthma and obesity are two of the most prevalent public health issues for children in the U.S. Trajectories of both have roughly paralleled one another over the past several decades causing many to explore their connection to one another and to other associated health issues such as diabetes and dyslipidemia. Earlier models have commonly designated obesity as the central hub of these associations; however, more recent models have argued connections between pediatric asthma and other obesity-related metabolic conditions regardless of children's obesity risk...
April 20, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29674378/the-caval-sphincter-in-cetaceans-and-its-predicted-role-in-controlling-venous-flow-during-a-dive
#8
Margo A Lillie, A Wayne Vogl, Stephen Raverty, Martin Haulena, William A McLellan, Garry B Stenson, Robert E Shadwick
A sphincter on the inferior vena cava can protect the heart of a diving mammal from overload when elevated abdominal pressures increase venous return, yet sphincters are reported incompetent or absent in some cetacean species. We previously hypothesized that abdominal pressures are elevated and pulsatile in fluking cetaceans, and that collagen is deposited on the diaphragm according to pressure levels to resist deformation. Here we tested the hypothesis that cetaceans generating high abdominal pressures need a more robust sphincter than those generating low pressures...
April 19, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29669931/targeting-the-gut-microbiome-to-treat-the-osteoarthritis-of-obesity
#9
Eric M Schott, Christopher W Farnsworth, Alex Grier, Jacquelyn A Lillis, Sarah Soniwala, Gregory H Dadourian, Richard D Bell, Madison L Doolittle, David A Villani, Hani Awad, John P Ketz, Fadia Kamal, Cheryl Ackert-Bicknell, John M Ashton, Steven R Gill, Robert A Mooney, Michael J Zuscik
Obesity is a risk factor for osteoarthritis (OA), the greatest cause of disability in the US. The impact of obesity on OA is driven by systemic inflammation, and increased systemic inflammation is now understood to be caused by gut microbiome dysbiosis. Oligofructose, a nondigestible prebiotic fiber, can restore a lean gut microbial community profile in the context of obesity, suggesting a potentially novel approach to treat the OA of obesity. Here, we report that - compared with the lean murine gut - obesity is associated with loss of beneficial Bifidobacteria, while key proinflammatory species gain in abundance...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29663262/characteristics-treatment-patterns-and-economic-outcomes-of-patients-initiating-injectable-medications-for-management-of-type-2-diabetes-mellitus-in-japan-results-from-a-retrospective-claims-database-analysis
#10
Shuichi Suzuki, Urvi Desai, Alena Strizek, Jasmina Ivanova, Viviana Garcia-Horton, Zhihong Cai, Luke Schmerold, Xinyue Liu, Magaly Perez-Nieves
INTRODUCTION: This study's objective was to describe characteristics, treatment patterns, and economic outcomes of type 2 diabetes mellitus (T2DM) patients initiating injectable antidiabetic medications in Japan. METHODS: Adults (≥ 18 years) with T2DM, ≥ 2 claims for injectable antidiabetics between 1 August 2011 and 31 July 2015 (first claim = index date), no evidence of type 1 diabetes mellitus, ≤ 1 claim for insulin, no claims for GLP-1RA before index, and continuous enrollment for 6 months before (baseline) and 12 months after index (follow-up) were selected from the Japan Medical Center Database...
April 16, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29659344/book-review-lilli-de-jong-a-novel-benton-j-2017-lilli-de-jong-a-novel-new-york-ny-nan-a-talese-doubleday-335-pp-26-95-hard-cover-isbn-9780385541459
#11
Bernice Hausman
No abstract text is available yet for this article.
May 2018: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/29657334/awareness-analysis-and-action-curricular-alignment-for-student-success-in-general-chemistry
#12
Sarah Jewett, Kathy Sutphin, Tiffany Gierasch, Pauline Hamilton, Kathleen Lilly, Kristine Miller, Donald Newlin, Richard Pires, Maureen Sherer, William R LaCourse
This article examines the ways that a shared faculty experience across five partner institutions led to a deep awareness of the curriculum and pedagogy of general chemistry coursework, and ultimately, to a collaborative action plan for student success. The team identified key differences and similarities in course content and instructional experiences. The comparative analysis yielded many more similarities than differences, and therefore, the team shifted its focus from "gap analysis" to an exploration of common curricular challenges...
February 13, 2018: Journal of Chemical Education
https://www.readbyqxmd.com/read/29656032/bioenergetics-and-synaptic-plasticity-as-potential-targets-for-individualizing-treatment-for-depression
#13
REVIEW
J Blair Price, Carrie Bronars, Sophie Erhardt, Kathyrn R Cullen, Lilly Schwieler, Michael Berk, Ken Walder, Sean L McGee, Mark A Frye, Susannah J Tye
Disruptions of bioenergetic signaling and neurogenesis are hallmarks of depression physiology and are often the product of dysregulation of the inflammatory, stress-response, and metabolic systems. These systems are extensively interrelated at the physiological level, yet the bulk of the literature to date addresses pathophysiological mechanisms in isolation. A more integrated understanding of the etiology, progression, and treatment response profiles of depression is possible through wider consideration of relevant preclinical and clinical studies that examine the result of disruptions in these systems...
April 12, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29649002/jak1-2-inhibition-with-baricitinib-in-the-treatment-of-autoinflammatory-interferonopathies
#14
Gina A Montealegre Sanchez, Adam Reinhardt, Suzanne Ramsey, Helmut Wittkowski, Philip J Hashkes, Yackov Berkun, Susanne Schalm, Sara Murias, Jason A Dare, Diane Brown, Deborah L Stone, Ling Gao, Thomas Klausmeier, Dirk Foell, Adriana A de Jesus, Dawn C Chapelle, Hanna Kim, Samantha Dill, Robert Colbert, Laura Failla, Bahar Kost, Michelle O'Brien, James C Reynolds, Les R Folio, Katherine R Calvo, Scott M Paul, Nargues Weir, Alessandra Brofferio, Ariane Soldatos, Angélique Biancotto, Edward W Cowen, John G Digiovanna, Massimo Gadina, Andrew J Lipton, Colleen Hadigan, Steven M Holland, Joseph Fontana, Ahmad S Alawad, Rebecca J Brown, Kristina I Rother, Theo Heller, Kristina M Brooks, Parag Kumar, Stephen R Brooks, Meryl Waldman, Harsharan K Singh, Volker Nickeleit, Maria Silk, Apurva Prakash, Jonathan M Janes, Seza Ozen, Paul G Wakim, Paul A Brogan, William L Macias, Raphaela Goldbach-Mansky
BACKGROUND: Monogenic Interferon (IFN)-mediated autoinflammatory diseases present in infancy with systemic inflammation, an IFN-response-gene-signature (IRS), inflammatory organ damage and high mortality. We used the janus kinase (JAK) inhibitor baricitinib with IFN-blocking activity in vitro, to ameliorate disease. METHODS: Between October 2011 and February 2017, 10 patients with CANDLE (chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperatures), 4 with SAVI (Stimulator of IFN genes (STING)-associated vasculopathy with onset in infancy), and 4 patients with other interferonopathies were enrolled in an Expanded Access Program...
April 12, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29644618/adherence-to-basal-insulin-therapy-among-people-with-type-2-diabetes-a-retrospective-cohort-study-of-costs-and-patient-outcomes
#15
Magaly Perez-Nieves, Kristina S Boye, Jacek Kiljanski, Dachung Cao, Maureen J Lage
INTRODUCTION: This research compares costs, resource utilization, and complications between adherent and nonadherent patients over the 3-year period post initiation on basal insulin therapy. METHODS: The study utilized the US-based Truven Health MarketScan® Research Databases from 2011 through 2015. Adults aged 18 years or older and identified with type 2 diabetes (T2D) who initiated therapy on basal insulin in 2012 were included. Patients were excluded if they were pregnant, filled their index basal insulin prescription via mail order, or were not continuously insured from 1 year before through 3 years following initiation of treatment with basal insulin...
April 11, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29642791/cme
#16
Lilly Meyer, Andrea Schück, Urs Bürgi, Lars C Huber
No abstract text is available yet for this article.
April 2018: Praxis
https://www.readbyqxmd.com/read/29642590/characterizing-phage-genomes-for-therapeutic-applications
#17
Casandra W Philipson, Logan J Voegtly, Matthew R Lueder, Kyle A Long, Gregory K Rice, Kenneth G Frey, Biswajit Biswas, Regina Z Cer, Theron Hamilton, Kimberly A Bishop-Lilly
Multi-drug resistance is increasing at alarming rates. The efficacy of phage therapy, treating bacterial infections with bacteriophages alone or in combination with traditional antibiotics, has been demonstrated in emergency cases in the United States and in other countries, however remains to be approved for wide-spread use in the US. One limiting factor is a lack of guidelines for assessing the genomic safety of phage candidates. We present the phage characterization workflow used by our team to generate data for submitting phages to the Federal Drug Administration (FDA) for authorized use...
April 10, 2018: Viruses
https://www.readbyqxmd.com/read/29626591/impact-of-the-canadian-diabetes-association-guidelines-dissemination-strategy-on-clinician-knowledge-and-behaviour-change-outcomes
#18
Catherine H Yu, Erin Lillie, Alekhya Mascarenhas-Johnson, Carolyn Gall Casey, Sharon E Straus
AIM: Implementation of clinical practice guideline(CPG) into clinical practice remains limited. Using the Knowledge-To-Action framework, a guideline dissemination and implementation strategy for the Canadian Diabetes Association's 2013 CPG was developed and launched to clinicians and people with diabetes. METHODS: The RE-AIM framework guided evaluation of this strategy clinician; we report here one aspect of the effectiveness dimension using mixed methods. We measured impact of the strategy on clinican knowledge and behaviour change constructs using evaluation forms, national online survey and individual interviews...
April 4, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29620857/synthesis-of-sub-10-nm-two-dimensional-covalent-organic-thin-film-with-sharp-molecular-sieving-nanofiltration
#19
Ikhlas Gadwal, Guan Sheng, Roshni Lilly Thankamony, Yang Liu, Huifang Li, Zhiping Lai
We demonstrated here a novel and facile synthesis of two-dimensional (2D) covalent organic thin film with pore size around 1.5 nm using a planar, amphiphilic and substituted heptacyclic truxene based triamine and a simple dialdehyde as building blocks by dynamic imine bond formation at the air/water interface using Langmuir-Blodgett (LB) method. Optical microscopy (OM), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and atomic force microscopy (AFM), all unanimously showed the formation of large, molecularly thin and free-standing membrane that can be easily transferred on different substrate surfaces...
April 6, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29619910/impact-of-sofosbuvir-based-regimens-for-the-treatment-of-hepatitis-c-after-liver-transplant-on-renal-function-results-of-a-canadian-national-retrospective-study
#20
Nabiha Faisal, Marc Bilodeau, Bandar Aljudaibi, Geri Hirch, Eric M Yoshida, Trana Hussaini, Maged P Ghali, Stephen E Congly, Mang M Ma, Leslie B Lilly
OBJECTIVES: We assessed the impact of sofosbuvir-based regimens on renal function in liver transplant recipients with recurrent hepatitis C virus and the role of renal function on the efficacy and safety of these regimens. MATERIALS AND METHODS: In an expanded pan-Canadian cohort, 180 liver transplant recipients were treated with sofosbuvir-based regimens for hepatitis C virus recurrence from January 2014 to May 2015. Mean age was 58 ± 6.85 years, and 50% had F3/4 fibrosis...
April 4, 2018: Experimental and Clinical Transplantation
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