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https://www.readbyqxmd.com/read/28212998/what-factors-do-patients-consider-most-important-in-making-lung-cancer-screening-decisions-findings-from-a-demonstration-project-conducted-in-the-veterans-health-administration
#1
Sarah E Lillie, Steven S Fu, Angela E Fabbrini, Kathryn L Rice, Barbara Clothier, David B Nelson, Elizabeth A Doro, M Anas Moughrabieh, Melissa R Partin
INTRODUCTION: The National Lung Screening Trial recently reported that annual low-dose computed tomography screening is associated with decreased lung cancer mortality in high-risk smokers. This study sought to identify the factors patients consider important in making lung cancer screening (LCS) decisions, and explore variations by patient characteristics and LCS participation. MATERIAL AND METHODS: This observational survey study evaluated the Minneapolis VA LCS Clinical Demonstration Project in which LCS-eligible Veterans (N=1388) were randomized to either Direct LCS Invitation (mailed with decision aid, N=926) or Usual Care (provider referral, N=462)...
February 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28212801/notch-signaling-in-vascular-smooth-muscle-cells
#2
J T Baeten, B Lilly
The Notch signaling pathway is a highly conserved pathway involved in cell fate determination in embryonic development and also functions in the regulation of physiological processes in several systems. It plays an especially important role in vascular development and physiology by influencing angiogenesis, vessel patterning, arterial/venous specification, and vascular smooth muscle biology. Aberrant or dysregulated Notch signaling is the cause of or a contributing factor to many vascular disorders, including inherited vascular diseases, such as cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, associated with degeneration of the smooth muscle layer in cerebral arteries...
2017: Advances in Pharmacology
https://www.readbyqxmd.com/read/28210352/risk-of-skin-and-soft-tissue-infections-among-children-found-to-be-staphylococcus-aureus-mrsa-usa300-carriers
#3
Lilly Cheng Immergluck, Shabnam Jain, Susan M Ray, Robert Mayberry, Sarah Satola, Trisha Chan Parker, Keming Yuan, Anaam Mohammed, Robert C Jerris
INTRODUCTION: The purpose of this study was to examine community-associated methicillin resistant Staphylococcus aureus (CA-MRSA) carriage and infections and determine risk factors associated specifically with MRSA USA300. METHODS: We conducted a case control study in a pediatric emergency department. Nasal and axillary swabs were collected, and participants were interviewed for risk factors. The primary outcome was the proportion of S. aureus carriers among those presenting with and without a skin and soft tissue infection (SSTI)...
February 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28210100/the-cost-effectiveness-of-a-nsclc-patient-assistance-program-for-pemetrexed-maintenance-therapy-in-people-s-republic-of-china
#4
Qiang Shi, Shanlian Hu, Wesley E Furnback, Gregory F Guzauskas, Jiejing Shen, Bruce Cm Wang
BACKGROUND: Eli Lilly and the China Primary Health Care Foundation are currently implementing a patient assistance program (PAP) in China, which allows first-line nonsquamous non-small-cell lung cancer (NSCLC) patients who complete four cycles of pemetrexed induction therapy to receive free, continuous pemetrexed maintenance therapy. OBJECTIVE: To estimate the cost-effectiveness of pemetrexed maintenance therapy vs basic standard care (BSC) and the economic impacts of providing a PAP for pemetrexed maintenance therapy to NSCLC patients who have completed pemetrexed induction therapy in a Chinese health care setting...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28207613/vagal-regulation-of-cardiac-function-in-early-childhood-and-cardiovascular-risk-in-adolescence
#5
Meghan J Gangel, Lilly Shanahan, Jacek Kolacz, James A Janssen, Ashley Brown, Susan D Calkins, Susan P Keane, Laurie Wideman
OBJECTIVE: Poor behavioral self-regulation in the first two decades of life has been identified as an important precursor of disease risk in adulthood. However, physiological regulation has not been well-studied as a disease risk factor before adulthood. We tested whether physiological regulation at age two, in the form of vagal regulation of cardiac function (indexed by RSA change), would predict three indicators of cardiovascular risk at age 16 (diastolic and systolic blood pressure and body mass index)...
February 15, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28202506/recurrent-patterns-of-dna-copy-number-alterations-in-tumors-reflect-metabolic-selection-pressures
#6
Nicholas A Graham, Aspram Minasyan, Anastasia Lomova, Ashley Cass, Nikolas G Balanis, Michael Friedman, Shawna Chan, Sophie Zhao, Adrian Delgado, James Go, Lillie Beck, Christian Hurtz, Carina Ng, Rong Qiao, Johanna Ten Hoeve, Nicolaos Palaskas, Hong Wu, Markus Müschen, Asha S Multani, Elisa Port, Steven M Larson, Nikolaus Schultz, Daniel Braas, Heather R Christofk, Ingo K Mellinghoff, Thomas G Graeber
Copy number alteration (CNA) profiling of human tumors has revealed recurrent patterns of DNA amplifications and deletions across diverse cancer types. These patterns are suggestive of conserved selection pressures during tumor evolution but cannot be fully explained by known oncogenes and tumor suppressor genes. Using a pan-cancer analysis of CNA data from patient tumors and experimental systems, here we show that principal component analysis-defined CNA signatures are predictive of glycolytic phenotypes, including (18)F-fluorodeoxy-glucose (FDG) avidity of patient tumors, and increased proliferation...
February 15, 2017: Molecular Systems Biology
https://www.readbyqxmd.com/read/28199814/baricitinib-versus-placebo-or-adalimumab-in-rheumatoid-arthritis
#7
Peter C Taylor, Edward C Keystone, Désirée van der Heijde, Michael E Weinblatt, Liliana Del Carmen Morales, Jaime Reyes Gonzaga, Sergey Yakushin, Taeko Ishii, Kahaku Emoto, Scott Beattie, Vipin Arora, Carol Gaich, Terence Rooney, Douglas Schlichting, William L Macias, Stephanie de Bono, Yoshiya Tanaka
Background Baricitinib is an oral, reversible inhibitor of the Janus kinases JAK1 and JAK2 that may have therapeutic value in patients with rheumatoid arthritis. Methods We conducted a 52-week, phase 3, double-blind, placebo- and active-controlled trial in which 1307 patients with active rheumatoid arthritis who were receiving background therapy with methotrexate were randomly assigned to one of three regimens in a 3:3:2 ratio: placebo (switched to baricitinib after 24 weeks), 4 mg of baricitinib once daily, or 40 mg of adalimumab (an anti-tumor necrosis factor α monoclonal antibody) every other week...
16, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28195777/hiv-prevention-opportunities-with-gps-based-social-and-sexual-networking-applications-for-men-who-have-sex-with-men
#8
Wendasha Jenkins Hall, Christina J Sun, Amanda E Tanner, Lilli Mann, Jason Stowers, Scott D Rhodes
The goal of this study was to gain insight on the sexual health needs of men who have sex with men (MSM) who use GPS-based social and sexual networking mobile applications (apps) and the future utility of app-based interventions. A health educator promoted HIV-testing resources in four popular apps used by MSM. Content analysis was used to identify salient themes that emerged from the conversations. Four major themes were identified: (1) soliciting sexual encounters, (2) relationship building, (3) HIV and STI-testing inquiries, and (4) seeking other sexual health information...
February 2017: AIDS Education and Prevention: Official Publication of the International Society for AIDS Education
https://www.readbyqxmd.com/read/28195589/preterm-arteries-in-childhood-dimensions-intima-media-thickness-and-elasticity-of-the-aorta-coronaries-and-carotids-in-6-y-old-children-born-extremely-preterm
#9
Lilly-Ann Mohlkert, Jenny Hallberg, Olof Broberg, Monica Hellström, Cecilia Pegelow Halvorsen, Gunnar Sjöberg, Anna-Karin Edstedt Bonamy, Petru Liuba, Vineta Fellman, Magnus Domellöf, Mikael Norman
BACKGROUND: Preterm birth increases risk for adult cardiovascular disease. We hypothesized that arteries in 6-y-old children born preterm are narrower, with thicker intima-media and stiffer than in peers born at term. METHODS: Children born extremely preterm (EXP, n = 176, birthweights: 348-1,161 g) and at term (CTRL, n = 174, birthweights: 2,430-4,315 g) were included. Using ultrasonography, we determined diameters of the coronaries (CA), common carotid arteries (CCA) and aorta, the carotid intima media thickness (cIMT), and the stiffness index of the CCA and aorta...
February 2017: Pediatric Research
https://www.readbyqxmd.com/read/28175443/135%C3%A2-a-comparison-of-outcomes-between-deep-brain-stimulation-under-general-anesthesia-versus-conscious-sedation-with-awake-evaluation
#10
François Alesch, Roshini Jain, Lilly Chen, Thomas Brucke, Fernando Seijo, Esther Suarez San Martin, Claire Haegelen, Marc Verin, Mohammed Maarouf, Michael T Barbe, Steven Gill, Alan Whone, Mauro Porta, Domenico Servello, Lars Timmermann
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28175388/134%C3%A2-vantage-trial-three-year-outcomes-of-a-prospective-multicenter-trial-evaluating-deep-brain-stimulation-with-a-new-multiple-source-constant-current-rechargeable-system-in-parkinson-disease
#11
Lars Timmermann, Roshini Jain, Lilly Chen, Thomas Brucke, Fernando Seijo, Esther Suarez San Martin, Claire Haegelen, Marc Verin, Veerle Visser-Vandewalle, Michael T Barbe, Steven Gill, Alan Whone, Mauro Porta, Domenico Servello, Francois Alesch
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28173764/-medically-unexplained-symptoms-and-symptom-disorders-in-primary-care-prognosis-based-recognition-and-classification
#12
EDITORIAL
Marianne Rosendal, Tim C Olde Hartman, Aase Aamland, Henriette van der Horst, Peter Lucassen, Anna Budtz-Lilly, Christopher Burton
BACKGROUND: Many patients consult their GP because they experience bodily symptoms. In a substantial proportion of cases, the clinical picture does not meet the existing diagnostic criteria for diseases or disorders. This may be because symptoms are recent and evolving or because symptoms are persistent but, either by their character or the negative results of clinical investigation cannot be attributed to disease: so-called "medically unexplained symptoms" (MUS). MUS are inconsistently recognised, diagnosed and managed in primary care...
February 7, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28170143/prevalence-of-brain-injuries-and-recurrence-of-seizures-in-children-with-post-traumatic-seizures
#13
Mohamed K Badawy, Peter S Dayan, Michael G Tunik, Frances M Nadel, Kathleen A Lillis, Michelle Miskin, Dominic A Borgialli, Michael C Bachman, Shireen M Atabaki, John D Hoyle, James F Holmes, Nathan Kuppermann
OBJECTIVES: Computed tomography (CT) is often used in the emergency department (ED) evaluation of children with post-traumatic seizures (PTS); however, the frequency of traumatic brain injuries (TBI) and short-term seizure recurrence is lacking. Our main objective was to evaluate the frequency of TBI on CT and short-term seizure recurrence in children with PTS. We also aimed to determine the associations between the likelihood of TBI on CT with the timing of onset of PTS after the traumatic event and duration of PTS...
February 7, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28169164/structure-based-design-and-sar-development-of-5-6-dihydroimidazolo-1-5-f-pteridine-derivatives-as-novel-polo-like-kinase-1-inhibitors
#14
Andre Kiryanov, Srinivasa Natala, Benjamin Jones, Christopher McBride, Victoria Feher, Betty Lam, Yan Liu, Kouhei Honda, Noriko Uchiyama, Tomohiro Kawamoto, Yuichi Hikichi, Lilly Zhang, David Hosfield, Robert Skene, Hua Zou, Jeffrey Stafford, Xiaodong Cao, Takashi Ichikawa
Using structure-based drug design, we identified a novel series of 5,6-dihydroimidazolo[1,5-f]pteridine PLK1 inhibitors. Rational improvements to compounds of this class resulted in single-digit nanomolar enzyme and cellular activity against PLK1, and oral bioavailability. Compound 1 exhibits >7 fold induction of phosphorylated Histone H3 and is efficacious in an in vivo HT-29 tumor xenograft model.
October 15, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28165171/less-is-more-neural-activity-during-very-brief-and-clearly-visible-exposure-to-phobic-stimuli
#15
Paul Siegel, Richard Warren, Zhishun Wang, Jie Yang, Don Cohen, Jason F Anderson, Lilly Murray, Bradley S Peterson
Research on automatic processes in fear has emphasized the provocation of fear responses rather than their attenuation. We have previously shown that the repeated presentation of feared images without conscious awareness via backward masking reduces avoidance of a live tarantula in spider-phobic participants. Herein we investigated the neural basis for these adaptive effects of masked exposure. 21 spider-phobic and 21 control participants, identified by a psychiatric interview, fear questionnaire, and approaching a live tarantula, viewed stimuli in each of three conditions: (1) very brief exposure (VBE) to masked images of spiders, severely limited awareness; (2) clearly visible exposure (CVE) to spiders, full awareness; and (3) masked images of flowers (control), severely limited awareness...
February 6, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28160137/liver-transplantation-is-a-preferable-alternative-to-palliative-therapy-for-selected-patients-with-advanced-hepatocellular-carcinoma
#16
Aloysious D Aravinthan, Silvio G Bruni, Adam C Doyle, Hla-Hla Thein, Nicolas Goldaracena, Assaf Issachar, Leslie B Lilly, Nazia Selzner, Mamatha Bhat, Boraiah Sreeharsha, Markus Selzner, Anand Ghanekar, Mark S Cattral, Ian D McGilvray, Paul D Greig, Eberhard L Renner, David R Grant, Gonzalo Sapisochin
BACKGROUND: Patients with hepatocellular carcinoma (HCC) beyond the traditional criteria (advanced HCC) are typically offered palliation, which is associated with a 3-year survival rate lower than 30%. This study aimed to describe the outcomes for a subset of patients with advanced HCC who satisfied the Extended Toronto Criteria (ETC) and were listed for liver transplantation (LT). METHODS: All patients listed in the Toronto liver transplantation program with HCC beyond both the Milan and University of California, San Francisco criteria were included in this study...
February 3, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28157142/using-wikis-to-build-nursing-concept-maps-promoting-group-interactive-learning
#17
Lilly Mathew
No abstract text is available yet for this article.
February 2017: Computers, Informatics, Nursing: CIN
https://www.readbyqxmd.com/read/28156474/a-consolidated-screening-tool-for-supportive-oncology-needs-and-distress
#18
Lauren Allison Wiebe, Shelly S Lo, Catherine Deamant, Betty Roggenkamp, Urjeet Patel, Pam Khosla, Patricia A Robinson, Frank J Penedo, James Gerhart, Teresa Lillis, William Dale, Ana Gordon, Rajul Kothari, Rosa Berardi, Julia Rachel Trosman, Christine B Weldon
: 72 Background: The IOM 2013 Report recommends that supportive oncology care start at cancer diagnosis; the Commission on Cancer (CoC) standard 3.2 requires distress screening and indicated action. Screening tools are not standardized across institutions and often address only a portion of patients' supportive oncology needs. METHODS: A collaborative of 100+ clinicians, funded by The Coleman Foundation, developed a patient-centric consolidated screening tool based on validated instruments (NCCN Distress Problem List, PHQ-4, PROMIS) and IOM and CoC...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152899/initiating-a-lymphedema-screening-program-for-breast-cancer-patients-determining-variability-as-a-first-step-towards-standardization
#19
Susan E Ferguson, Sarah Marie DeSnyder, Parviz Kheirkhah, Susan Lilly, Marigold Travis, Theresa Johnson, Ana Alvarez, Duke Rohe, Thomas A Buchholz, Isabelle Bedrosian
: 267 Background: Breast cancer-related lymphedema (BCRL) is a known morbidity from treatment, and yet published estimates of its incidence are highly variable. Typically, a single volume measurement is recorded and the degree of intra-rater variability undefined. A threshold 5% limb volume change over time is used to define "mild lymphedema." Therefore, small variations in volume measurements could substantially lead to over or under-diagnosis of BRCL. Gage R&R is a measurement systems analysis tool that quantifies the amount of variability induced in measurements by the measurement system itself and compares this to the total variability observed...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28137644/measuring-the-effectiveness-and-impact-of-an-open-innovation-platform
#20
REVIEW
Glenn P Carroll, Sanjay Srivastava, Adam S Volini, Marta M Piñeiro-Núñez, Tatiana Vetman
Today, most pharmaceutical companies complement their traditional R&D models with some variation on the Open Innovation (OI) approach in an effort to better access global scientific talent, ideas and hypotheses. Traditional performance indicators that measure economic returns from R&D through commercialization are often not applicable to the practical assessment of these OI approaches, particularly within the context of early drug discovery. This leaves OI programs focused on early R&D without a standard assessment framework from which to evaluate overall performance...
January 27, 2017: Drug Discovery Today
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