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https://www.readbyqxmd.com/read/29912896/comparative-safety-and-effectiveness-of-perinatal-antiretroviral-therapies-for-hiv-infected-women-and-their-children-systematic-review-and-network-meta-analysis-including-different-study-designs
#1
Areti Angeliki Veroniki, Jesmin Antony, Sharon E Straus, Huda M Ashoor, Yaron Finkelstein, Paul A Khan, Marco Ghassemi, Erik Blondal, John D Ivory, Brian Hutton, Kevin Gough, Brenda R Hemmelgarn, Erin Lillie, Afshin Vafaei, Andrea C Tricco
BACKGROUND: Nearly all newly infected children acquire Human Immunodeficiency virus (HIV) via mother-to-child transmission (MTCT) during pregnancy, labour or breastfeeding from untreated HIV-positive mothers. Antiretroviral therapy (ART) is the standard care for pregnant women with HIV. However, evidence of ART effectiveness and harms in infants and children of HIV-positive pregnant women exposed to ART has been largely inconclusive. The aim of our systematic review and network meta-analysis (NMA) was to evaluate the comparative safety and effectiveness of ART drugs in children exposed to maternal HIV and ART (or no ART/placebo) across different study designs...
2018: PloS One
https://www.readbyqxmd.com/read/29911876/childhood-self-regulation-as-a-mechanism-through-which-early-overcontrolling-parenting-is-associated-with-adjustment-in-preadolescence
#2
Nicole B Perry, Jessica M Dollar, Susan D Calkins, Susan P Keane, Lilly Shanahan
We examined longitudinal associations across an 8-year time span between overcontrolling parenting during toddlerhood, self-regulation during early childhood, and social, emotional, and academic adjustment in preadolescence (N = 422). Overcontrolling parenting, emotion regulation (ER), and inhibitory control (IC) were observed in the laboratory; preadolescent adjustment was teacher-reported and child self-reported. Results from path analysis indicated that overcontrolling parenting at age 2 was associated negatively with ER and IC at age 5, which, in turn, were associated with more child-reported emotional and school problems, fewer teacher-reported social skills, and less teacher-reported academic productivity at age 10...
June 18, 2018: Developmental Psychology
https://www.readbyqxmd.com/read/29910024/dulaglutide-versus-insulin-glargine-in-patients-with-type-2-diabetes-and-moderate-to-severe-chronic-kidney-disease-award-7-a-multicentre-open-label-randomised-trial
#3
Katherine R Tuttle, Mark C Lakshmanan, Brian Rayner, Robert S Busch, Alan G Zimmermann, D Bradley Woodward, Fady T Botros
BACKGROUND: Many antihyperglycaemic drugs, including insulin, are primarily cleared by the kidneys, restricting treatment options for patients with kidney disease. Dulaglutide is a long-acting glucagon-like peptide-1 receptor agonist that is not cleared by the kidneys, and confers a lower risk of hypoglycaemia than does insulin. We assessed the efficacy and safety of dulaglutide in patients with type 2 diabetes and moderate-to-severe chronic kidney disease. METHODS: AWARD-7 was a multicentre, open-label trial done at 99 sites in nine countries...
June 14, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29909856/pulmonary-thromboembolic-events-in-patients-with-congenital-lipomatous-overgrowth-vascular-malformations-epidermal-nevi-and-spinal-skeletal-abnormalities-and-klippel-tr%C3%A3-naunay-syndrome
#4
Joseph Reis, Ahmad I Alomari, Cameron C Trenor, Denise M Adams, Steven J Fishman, Samantha A Spencer, Raja Shaikh, Anna P Lillis, Murali K Surnedi, Gulraiz Chaudry
OBJECTIVE: Patients with Klippel-Trénaunay syndrome (KTS) and congenital lipomatous overgrowth, vascular malformations, epidermal nevi, and spinal/skeletal abnormalities (CLOVES) syndrome have central phlebectasia and enlarged persistent embryonic veins that are often incompetent and prone to thromboembolism. The purpose of the study was to determine the presence of phlebectasia and the incidence of symptomatic pulmonary embolism (PE). METHODS: A retrospective review was conducted of patients referred to the Vascular Anomalies Center at our institution during a 21-year period who were diagnosed with KTS and CLOVES syndrome...
July 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29907539/serum-trough-level-as-a-postmarketing-quality-measure-of-generic-vancomycin-products
#5
Ya-Wen Tsai, Yu-Chiang Wang, Shian-Sen Shie, Min-Chi Chen, Yhu-Chering Huang, Chih-Jung Chen
BACKGROUND: The vancomycin trough level (VTL) is the most widely used pharmacokinetic parameter for monitoring its clinical efficacy. Whether the VTL is affected in patients receiving different vancomycin products has not previously been determined. METHODS: From 2005 to 2015, five vancomycin products, including the innovator (designated as VAN-Lilly) and four generic versions (designated as VAN-A, VAN-B, VAN-C and VAN-D), were sequentially used in a teaching hospital...
June 2, 2018: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29904291/medical-and-psychosocial-needs-of-the-puerto-rican-people-after-hurricane-maria
#6
Lilly Ramphal
A community clinic in Puerto Rico, the Bantiox Clinic, was developed to serve the medical needs of Toa Baja and the surrounding communities after Hurricanes Irma and Maria in response to an urgent need for medical treatment of the community residents. Within 4 months, the clinic had 4941 total visits. The Toa Baja residents used the clinic more than the offsite residents. Certain offsite towns needed medical care more than others, suggesting a lack of medical access in the mountainous areas. Elderly patients with chronic diseases were served more than younger patients...
July 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29899113/tribbles-homolog-1-deficiency-modulates-function-and-polarization-of-murine-bone-marrow-derived-macrophages
#7
Lilli Arndt, Janine Dokas, Martin Gericke, Carl Elias Kutzner, Silvana Müller, Franziska Jeromin, Joachim Thiery, Ralph Burkhardt
Macrophages are essential for innate immunity and inflammatory responses and differentiate into various functional phenotypes. Tribbles homolog 1 ( Trib1 ), a member of the mammalian Tribbles homolog pseudokinase family, has been implicated in regulation of cell differentiation, proliferation and metabolism, but its role in macrophage biology has not been fully elucidated. Here, we investigated the consequences of Trib1 deficiency on macrophage functions and M1/M2 polarization. Bone marrow-derived macrophages (BMDMs) from Trib1 -deficient ( Trib1 -/- ) mice exhibited elevated phagocytic capacity, correlating with up-regulation of several scavenger receptors...
June 13, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29898743/utility-of-social-media-and-crowd-intelligence-data-for-pharmacovigilance-a-scoping-review
#8
Andrea C Tricco, Wasifa Zarin, Erin Lillie, Serena Jeblee, Rachel Warren, Paul A Khan, Reid Robson, Ba' Pham, Graeme Hirst, Sharon E Straus
BACKGROUND: A scoping review to characterize the literature on the use of conversations in social media as a potential source of data for detecting adverse events (AEs) related to health products. METHODS: Our specific research questions were (1) What social media listening platforms exist to detect adverse events related to health products, and what are their capabilities and characteristics? (2) What is the validity and reliability of data from social media for detecting these adverse events? MEDLINE, EMBASE, Cochrane Library, and relevant websites were searched from inception to May 2016...
June 14, 2018: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29896847/advanced-chronic-kidney-disease-relationship-to-outcomes-post-tavr-a-meta-analysis
#9
REVIEW
Nader Makki, Scott M Lilly
OBJECTIVE: Chronic kidney (CKD) is associated with worse outcomes in high-surgical risk patients undergoing transcatheter aortic valve replacement (TAVR). However, it is unclear whether this relationship is apparent in lower surgical risk patients. Herein we sought to analyze existing literature to assess whether or not advanced CKD is associated with increased mortality, or a greater incidence of adverse events (specifically major stroke, bleeding and vascular complications). METHODS: We searched PubMed and EMBASE (2008-2017) for relevant studies...
June 12, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29888811/improved-glycaemic-control-and-treatment-satisfaction-with-a-simple-wearable-3-day-insulin-delivery-device-among-people-with-type-2-diabetes
#10
J K Mader, L C L Lilly, F Aberer, T Poettler, D Johns, M Trautmann, J Warner, T R Pieber
AIM: To evaluate the PAQ® (CeQur SA, Horw, Switzerland), a wearable 3-day insulin delivery device that provides set basal rates and bolus insulin on demand, in people with Type 2 diabetes. METHODS: Adults with Type 2 diabetes with HbA1c concentrations ≥53 and ≤97 mmol/mol (7.0 and 11.0%) while treated with ≥2 insulin injections/day were enrolled in two single-arm studies comprising three periods: a baseline (insulin injections), a transition and a PAQ treatment period (12 weeks)...
June 11, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29879409/importance-of-kynurenine-3-monooxygenase-for-spontaneous-firing-and-pharmacological-responses-of-midbrain-dopamine-neurons-relevance-for-schizophrenia
#11
Maximilian Tufvesson-Alm, Lilly Schwieler, Robert Schwarcz, Michel Goiny, Sophie Erhardt, Göran Engberg
Kynurenine 3-monooxygenase (KMO) is an essential enzyme of the kynurenine pathway, converting kynurenine into 3-hydroxykynurenine. Inhibition of KMO increases kynurenine, resulting in elevated levels of kynurenic acid (KYNA), an endogenous N-methyl-D-aspartate and α*7-nicotinic receptor antagonist. The concentration of KYNA is elevated in the brain of patients with schizophrenia, possibly as a result of a reduced KMO activity.In the present study, using in vivo single cell recording techniques, we investigated the electrophysiological characteristics of ventral tegmental area dopamine (VTA DA) neurons and their response to antipsychotic drugs in a KMO knock-out (K/O) mouse model...
June 4, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29874970/a-long-time-follow-up-study-of-a-single-center-endovascular-aneurysm-repair-evar-endoleak-outcomes
#12
Rosa Marie Andersen, Daniel P Henriksen, Hossein Mohit Mafi, Sten Langfeldt, Jacob Budtz-Lilly, Ole Graumann
PURPOSE: The aim of this study was to evaluate the incidence, risk factors, and outcome of endoleaks related to endovascular aneurysm repair (EVAR) procedure at a single center with up to 10 years' surveillance. MATERIALS AND METHODS: All patients treated with EVAR for an abdominal aorta or iliac aneurysm in a 10-year period at a single cardiovascular center in Denmark were included. Data were collected from a national database and patient journals. Follow-up computed tomography angiography and plain abdominal X-ray reports were reviewed...
January 1, 2018: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29868248/applying-fecal-microbiota-transplantation-fmt-to-treat-recurrent-clostridium-difficile-infections-rcdi-in-children
#13
Shaaz Fareed, Neha Sarode, Frank J Stewart, Aneeq Malik, Elham Laghaie, Saadia Khizer, Fengxia Yan, Zoe Pratte, Jeffery Lewis, Lilly Cheng Immergluck
Background: Fecal Microbiota Transplantation (FMT) is an innovative means of treating recurrent Clostridium difficile infection (rCDI), through restoration of gut floral balance. However, there is a lack of data concerning the efficacy of FMT and its impact on the gut microbiome among pediatric patients. This study analyzes clinical outcomes and microbial community composition among 15 pediatric patients treated for rCDI via FMT. Methods: This is a prospective, observational, pilot study of 15 children ≤18 years, who presented for rCDI and who met inclusion criteria for FMT at a pediatric hospital and pediatric gastroenterology clinic...
2018: PeerJ
https://www.readbyqxmd.com/read/29868039/constraint-based-modeling-highlights-cell-energy-redox-status-and-%C3%AE-ketoglutarate-availability-as-metabolic-drivers-for-anthocyanin-accumulation-in-grape-cells-under-nitrogen-limitation
#14
Eric Soubeyrand, Sophie Colombié, Bertrand Beauvoit, Zhanwu Dai, Stéphanie Cluzet, Ghislaine Hilbert, Christel Renaud, Lilly Maneta-Peyret, Martine Dieuaide-Noubhani, Jean-Michel Mérillon, Yves Gibon, Serge Delrot, Eric Gomès
Anthocyanin biosynthesis is regulated by environmental factors (such as light, temperature, and water availability) and nutrient status (such as carbon, nitrogen, and phosphate nutrition). Previous reports show that low nitrogen availability strongly enhances anthocyanin accumulation in non carbon-limited plant organs or cell suspensions. It has been hypothesized that high carbon-to-nitrogen ratio would lead to an energy excess in plant cells, and that an increase in flavonoid pathway metabolic fluxes would act as an "energy escape valve," helping plant cells to cope with energy and carbon excess...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29861339/a-systematic-review-of-medical-mistrust-measures
#15
REVIEW
Lillie D Williamson, Cabral A Bigman
OBJECTIVE: Medical mistrust is seen as a barrier to health promotion and addressing health disparities among marginalized populations. This study seeks to examine how medical mistrust has been measured as a step towards informing related health promotion efforts. METHODS: A systematic review of medical mistrust scales was conducted using four major databases: PubMed, PsycINFO, ERIC, and Communication & Mass Media Complete. Databases were searched using the terms "medical mistrust scale" "medical mistrust" and "medical distrust...
May 17, 2018: Patient Education and Counseling
https://www.readbyqxmd.com/read/29861180/multi-epitope-dnak-peptide-vaccine-against-s-typhi-an-in-silico-approach
#16
Shivani Verma, Ragumani Sugadev, Ashish Kumar, Sudhir Chandna, Lilly Ganju, Anju Bansal
Salmonella is one of the key global causes of food and water borne enteric infections, responsible for significant morbidity and mortality worldwide especially in developing countries. Currently available vaccines against typhoid are moderately effective with several side effects and not efficacious against all Salmonella serovars. Due to limitations of these vaccines and emerging threats of multidrug resistance, developing an effective vaccine against these infections has increasingly become a priority. Heat shock proteins (Hsps), being evolutionarily conserved, represent dominant antigens in the host immune response...
May 31, 2018: Vaccine
https://www.readbyqxmd.com/read/29860014/extended-length-of-stay-in-elderly-patients-after-lumbar-decompression-and-fusion-surgery-is-may-not-be-attributable-to-baseline-illness-severity-or-postoperative-complications
#17
Owoicho Adogwa, Shyam A Desai, Victoria D Vuong, Daniel T Lilly, Bichun Ouyang, Mark Davison, Syed Khalid, Carlos A Bagley, Joseph Cheng
BACKGROUND: Hospital leaders are seeking ways to improve resource utilization and minimize long postoperative hospital stays. Common explanations for extended stay are baseline patient illness, postoperative complications, or physician practice differences. However, the degree extended length of stay (LOS) represents illness severity or postoperative complications remains unknown. The aim is to investigate the influence of postoperative complications and patient comorbidities on extended length of stay after lumbar spine surgery in elderly patients...
May 31, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29851541/book-review-lilli-de-jong-a-novel-benton-j-2017-lilli-de-jong-a-novel-new-york-ny-nan-a-talese-doubleday-335-pp-26-95-hard-cover-isbn-9780385541459
#18
Bernice Hausman
No abstract text is available yet for this article.
May 2018: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/29850709/a%C3%A3-a%C3%A3-euterpe-oleracea-mart-beverage-consumption-improves-biomarkers-for-inflammation-but-not-glucose-or-lipid-metabolism-in-individuals-with-metabolic-syndrome-in-a-randomized-double-blinded-placebo-controlled-clinical-trial
#19
Hyemee Kim, Sunday Y Simbo, Chuo Fang, Lilly McAlister, Andrea Roque, Nivedita Banerjee, Stephen T Talcott, Hongwei Zhao, Richard B Kreider, Susanne U Mertens-Talcott
Açaí (Euterpe oleracea Mart.) berries, characterized by high polyphenol concentrations (predominantly anthocyanins), have demonstrated anti-inflammatory and anti-diabetic activities. The study objective was to determine the modulation of lipid and glucose-metabolism, as well as oxidative stress and inflammation, by an açaí-beverage (containing 1139 mg L-1 gallic acid equivalents of total polyphenolics) in 37 individuals with metabolic syndrome (BMI 33.5 ± 6.7 kg m-2) who were randomized to consume 325 mL twice per d of a placebo control or açaí-beverage for 12 weeks...
May 31, 2018: Food & Function
https://www.readbyqxmd.com/read/29846932/treatment-patterns-of-newly-diagnosed-rheumatoid-arthritis-patients-from-a-commercially-insured-population
#20
David M Kern, Lawrence Chang, Kalyani Sonawane, Cynthia J Larmore, Natalie N Boytsov, Ralph A Quimbo, Joseph Singer, John T Hinton, Sze-Jung Wu, Andre B Araujo
INTRODUCTION: To describe treatment patterns in newly diagnosed rheumatoid arthritis (RA) patients in a large, nationally representative managed-care database. METHODS: Newly diagnosed RA patients were identified from 07/01/2006-08/31/2014. Patients had ≥ 1 RA diagnosis by a rheumatologist, or ≥ 2 non-rheumatologist RA diagnoses ≥ 30 days apart, or RA diagnosis followed by a disease-modifying antirheumatic drug (DMARD) prescription fill within 1 year. Patients were ≥ 18 years old at index (earliest date fulfilling diagnostic criteria) and had ≥ 6 and 12 months of pre- and post-index health plan enrollment, respectively...
May 30, 2018: Rheumatology and Therapy
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