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https://www.readbyqxmd.com/read/28822643/genetic-background-impacts-vaccine-induced-reduction-of-pneumococcal-colonization
#1
Kirsten Kuipers, Saskia van Selm, Fred van Opzeeland, Jeroen D Langereis, Lilly M Verhagen, Dimitri A Diavatopoulos, Marien I de Jonge
Vaccination has been one of the most successful strategies to reduce morbidity and mortality caused by respiratory infections. Recent evidence suggests that differences in the host genetic background and environmental factors may contribute to heterogeneity in the immune response to vaccination. During pre-clinical testing, vaccines are often evaluated in a single mouse inbred strain, which may not translate well to the heterogeneous human population. Here, we examined the influence of host genetic background on vaccine-induced protection against pneumococcal colonization in two commonly used inbred mouse strains, i...
August 16, 2017: Vaccine
https://www.readbyqxmd.com/read/28822333/virtual-screening-and-repositioning-of-inconclusive-molecules-of-beta-lactamase-bioassays-a-data-mining-approach
#2
Akshata Gad, Andrew Titus Manuel, Jinuraj K R, Lijo John, Sajeev R, Shanmuga Priya V G, Abdul Jaleel U C
This study focuses on the best possible way forward in utilizing inconclusive molecules of PubChem bioassays AID 1332, AID 434987 and AID 434955, which are related to beta-lactamase inhibitors of Mycobacterium tuberculosis (Mtb). The inadequacy in the experimental methods that were observed during the invitro screening resulted in an inconclusive dataset. This could be due to certain moieties present within the molecules. In order to reconsider such molecules, insilico methods can be suggested in place of invitro methods For instance, datamining and medicinal chemistry methods: have been adopted to prioritise the inconclusive dataset into active or inactive molecules...
July 29, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28819835/efficacy-and-safety-of-linagliptin-in-2681-asian-patients-stratified-by-age-obesity-and-renal-function-a-pooled-analysis-of-randomized-clinical-trials
#3
Guang Ning, Tushar Bandgar, Uwe Hehnke, Jisoo Lee, Juliana C N Chan
INTRODUCTION: Asian patients with type 2 diabetes (T2D) are younger, leaner, and more likely to develop renal dysfunction than White populations. In this multiethnic analysis of data from phase 3 trials, we investigated the efficacy and safety of the dipeptidyl peptidase-4 inhibitor linagliptin in Asians stratified by these subphenotypes. METHODS: Data from randomized, double-blind, placebo-controlled trials evaluating linagliptin (as monotherapy, add-on therapy to metformin ± sulfonylurea, combined with pioglitazone or added to insulin) were pooled with efficacy data from 11 randomized trials of at least 24 weeks and safety data from 15 trials of various durations...
August 17, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28816380/a-daily-diary-study-of-posttraumatic-stress-experiential-avoidance-and-emotional-lability-among-inpatient-nurses
#4
James Gerhart, Elizabeth Vaclavik, Teresa A Lillis, Jacob Miner, Rory McFadden, Sean O'Mahony
No abstract text is available yet for this article.
August 17, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28811926/postinjection-delirium-sedation-syndrome-in-patients-with-schizophrenia-receiving-olanzapine-long-acting-injection-results-from-a-large-observational-study
#5
Kristin J Meyers, Himanshu P Upadhyaya, John L Landry, Rashna Chhabra-Khanna, Deborah M Falk, Balasubramanya Seetharama Rao, Meghan E Jones
BACKGROUND: Postinjection delirium/sedation syndrome (PDSS) has been reported uncommonly during treatment with olanzapine long-acting injection (LAI), a sustained-release formulation of olanzapine. AIMS: The primary aim of the study was to estimate the incidence per injection and per patient of PDSS events in adult patients with schizophrenia who were receiving olanzapine LAI in real-world clinical practice. Secondary aims were to further characterise the clinical presentation of PDSS events, to identify potential risk factors associated with PDSS events and to characterise hospitalisations at baseline and post-baseline...
July 2017: BJPsych Open
https://www.readbyqxmd.com/read/28811828/nonvitamin-nonmineral-dietary-supplement-use-among-adults-with-fibromyalgia-united-states-2007-2012
#6
Termeh Feinberg, Christa Lilly, Kim Innes
BACKGROUND: Fibromyalgia (FMS) is a pain condition affecting 2-6% of US adults; effective treatment remains limited. Determinants of nonvitamin, nonmineral dietary supplement (NVNM) use among adults with FMS are not well-studied. We investigated the relation of NVNM use to FMS, and trends, in two nationally representative samples of US adults ≥18 years. METHODS: Data were drawn from 2007 and 2012 National Health Interview Surveys (N's = 20127 and 30672, resp.)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28810212/evaluation-of-bikers-against-child-abuse-baca-program-a-community-intervention-for-child-abuse-victims
#7
Dee C Ray, J P Lilly, Nancy Gallina, Paula MacIan, Brittany Wilson
Children who have experienced physical abuse benefit from a multitude of community interventions including support programs to address emotional and behavioral stability. This pilot study evaluated the services of Bikers Against Child Abuse (BACA), a community of bikers lending intervention to abused children, using a pre/post exploratory design. Participants (N=154) were children who had been referred by parents/guardians for current or past physical and/or sexual abuse. Parents/guardians of children were interviewed four times over a course of one year...
August 5, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/28807909/development-and-use-of-personalized-bacteriophage-based-therapeutic-cocktails-to-treat-a-patient-with-a-disseminated-resistant-acinetobacter-baumannii-infection
#8
Robert T Schooley, Biswajit Biswas, Jason J Gill, Adriana Hernandez-Morales, Jacob Lancaster, Lauren Lessor, Jeremy J Barr, Sharon L Reed, Forest Rohwer, Sean Benler, Anca M Segall, Randy Taplitz, Davey M Smith, Kim Kerr, Monika Kumaraswamy, Victor Nizet, Leo Lin, Melanie D McCauley, Steffanie A Strathdee, Constance A Benson, Robert K Pope, Brian M Leroux, Andrew C Picel, Alfred J Mateczun, Katherine E Cilwa, James M Regeimbal, Luis A Estrella, David M Wolfe, Matthew S Henry, Javier Quinones, Scott Salka, Kimberly A Bishop-Lilly, Ry Young, Theron Hamilton
Widespread antibiotic use in clinical medicine and the livestock industry has contributed to the global spread of multidrug-resistant (MDR) bacterial pathogens, including Acinetobacter baumannii We report on a method used to produce a personalized bacteriophage-based therapeutic treatment for a 68-year old diabetic patient with necrotizing pancreatitis complicated by a MDR A. baumannii infection. Despite multiple antibiotic courses and efforts at percutaneous drainage of a pancreatic pseudocyst, the patient deteriorated over a four-month period...
August 14, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28800866/five-year-trends-of-critical-care-practice-and-outcomes
#9
Craig M Lilly, Sunil Swami, Xinggang Liu, Richard R Riker, Omar Badawi
BACKGROUND: Longitudinal analyses of large detailed adult critical care datasets provide insights into practice trends and generate useful outcome and process benchmarks. METHODS: Data representing 991,571 consecutive critical care visits to160 United States adult ICUs during 2009 to 2013 from the eICU Research Institute clinical practice database were used to quantitate patient characteristics, APACHE IV based acuity predictions, treatments, and outcomes. Analyses for changes over time were performed for patient characteristics, entry and discharge locations, primary admission diagnosis, treatments, adherence to consensus ICU best practices, length of stay (LOS), and inpatient mortality...
August 8, 2017: Chest
https://www.readbyqxmd.com/read/28800605/stroke-survivors-with-severe-mental-illness-are-they-at-risk-for-increased-non-psychiatric-hospitalizations
#10
Flavius Robert Lilly, Joel Culpepper, Mary Stuart, Donald Steinwachs
BACKGROUND: This study examined outcomes for two groups of stroke survivors treated in Veteran Health Administration (VHA) hospitals, those with a severe mental illness (SMI) and those without prior psychiatric diagnoses, to examine risk of non-psychiatric medical hospitalizations over five years after initial stroke. METHODS: This retrospective cohort study included 523 veterans who survived an initial stroke hospitalization in a VHA medical center during fiscal year 2003...
2017: PloS One
https://www.readbyqxmd.com/read/28797112/a-novel-whole-bacterial-enzyme-linked-immunosorbant-assay-to-quantify-chlamydia-trachomatis-specific-antibodies-reveals-distinct-differences-between-systemic-and-genital-compartments
#11
Hannah L Albritton, Pamela A Kozlowski, Rebecca A Lillis, Chris L McGowin, Julia D Siren, Stephanie N Taylor, Joyce A Ibana, Lyndsey R Buckner, Li Shen, Alison J Quayle
Chlamydia trachomatis (CT) is the leading sexually transmitted bacterial infection. The continued global burden of CT infection strongly predicates the need for a vaccine to supplement current chlamydial control programs. The correlates of protection against CT are currently unknown, but they must be carefully defined to guide vaccine design. The localized nature of chlamydial infection in columnar epithelial cells of the genital tract necessitates investigation of immunity at the site of infection. The purpose of this study was to develop a sensitive whole bacterial enzyme-linked immunosorbent assay (ELISA) to quantify and compare CT-specific IgG and IgA in sera and genital secretions from CT-infected women...
2017: PloS One
https://www.readbyqxmd.com/read/28791299/differential-microrna-analyses-of-burkholderia-pseudomallei-and-francisella-tularensis-exposed-hpbmcs-reveal-potential-biomarkers
#12
Regina Z Cer, J Enrique Herrera-Galeano, Kenneth G Frey, Kevin L Schully, Truong V Luu, John Pesce, Vishwesh P Mokashi, Andrea M Keane-Myers, Kimberly A Bishop-Lilly
Increasing evidence that microRNAs (miRNAs) play important roles in the immune response against infectious agents suggests that miRNA might be exploitable as signatures of exposure to specific infectious agents. In order to identify potential early miRNA biomarkers of bacterial infections, human peripheral blood mononuclear cells (hPBMCs) were exposed to two select agents, Burkholderia pseudomallei K96243 and Francisella tularensis SHU S4, as well as to the nonpathogenic control Escherichia coli DH5α. RNA samples were harvested at three early time points, 30, 60, and 120 minutes postexposure, then sequenced...
2017: International Journal of Genomics
https://www.readbyqxmd.com/read/28767714/hiv-associated-mortality-in-the-era-of-antiretroviral-therapy-scale-up-nairobi-kenya-2015
#13
Peter W Young, Andrea A Kim, Joyce Wamicwe, Lilly Nyagah, Catherine Kiama, John Stover, Johansen Oduor, Emily A Rogena, Edwin Walong, Emily Zielinski-Gutierrez, Andrew Imbwaga, Martin Sirengo, Timothy A Kellogg, Kevin M De Cock
BACKGROUND: Declines in HIV prevalence and increases in antiretroviral treatment coverage have been documented in Kenya, but population-level mortality associated with HIV has not been directly measured. In urban areas where a majority of deaths pass through mortuaries, mortuary-based studies have the potential to contribute to our understanding of excess mortality among HIV-infected persons. We used results from a cross-sectional mortuary-based HIV surveillance study to estimate the association between HIV and mortality for Nairobi, the capital city of Kenya...
2017: PloS One
https://www.readbyqxmd.com/read/28765277/blood-pressure-in-6-year-old-children-born-extremely-preterm
#14
Anna-Karin Edstedt Bonamy, Lilly-Ann Mohlkert, Jenny Hallberg, Petru Liuba, Vineta Fellman, Magnus Domellöf, Mikael Norman
BACKGROUND: Advances in perinatal medicine have increased infant survival after very preterm birth. Although this progress is welcome, there is increasing concern that preterm birth is an emerging risk factor for hypertension at young age, with implications for the lifetime risk of cardiovascular disease. METHODS AND RESULTS: We measured casual blood pressures (BPs) in a population-based cohort of 6-year-old survivors of extremely preterm birth (<27 gestational weeks; n=171) and in age- and sex-matched controls born at term (n=172)...
August 1, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28754152/cerebrospinal-fluid-kynurenine-and-kynurenic-acid-concentrations-are-associated-with-coma-duration-and-long-term-neurocognitive-impairment-in-ugandan-children-with-cerebral-malaria
#15
Dag Holmberg, Elisabeth Franzén-Röhl, Richard Idro, Robert O Opoka, Paul Bangirana, Carl M Sellgren, Ronny Wickström, Anna Färnert, Lilly Schwieler, Göran Engberg, Chandy C John
BACKGROUND: One-fourth of children with cerebral malaria (CM) retain cognitive sequelae up to 2 years after acute disease. The kynurenine pathway of the brain, forming neuroactive metabolites, e.g. the NMDA-receptor antagonist kynurenic acid (KYNA), has been implicated in long-term cognitive dysfunction in other CNS infections. In the present study, the association between the kynurenine pathway and neurologic/cognitive complications in children with CM was investigated. METHODS: Cerebrospinal fluid (CSF) concentrations of KYNA and its precursor kynurenine in 69 Ugandan children admitted for CM to Mulago Hospital, Kampala, Uganda, between 2008 and 2013 were assessed...
July 28, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28751484/medication-incidents-in-primary-care-medicine-a-prospective-study-in-the-swiss-sentinel-surveillance-network-sentinella
#16
Markus Gnädinger, Dieter Conen, Lilli Herzig, Milo A Puhan, Alfred Staehelin, Marco Zoller, Alessandro Ceschi
OBJECTIVES: To describe the type, frequency, seasonal and regional distribution of medication incidents in primary care in Switzerland and to elucidate possible risk factors for medication incidents. DESIGN: Prospective surveillance study. SETTING: Swiss primary healthcare, Swiss Sentinel Surveillance Network. PARTICIPANTS: Patients with drug treatment who experienced any erroneous event related to the medication process and interfering with normal treatment course, as judged by their physician...
July 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/28746054/nutritional-deficiency-related-oral-and-cutaneous-lesions-in-an-obese-patient
#17
Lilly Esquivel-Pedraza, Silvia Méndez-Flores, Alba Cicero-Casarrubias, Marcela Saeb-Lima, Judith Domínguez-Cherit, Laura Fernández-Cuevas
The cutaneous and oral lesions related to nutritional deficiencies are scarcely reported. Micronutrient deficiencies may significantly affect mouth mucosa and skin, causing great morbidity. We report an extraordinary case with detailed clinical and microscopic findings affecting the oral cavity and skin. Physicians must be familiar with these manifestations to suspect the diagnosis.
July 17, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28745112/aktuelle-behandlungskonzepte-bei-belastungsinkontinenz
#18
Oliver Rautenberg, Irena Zivanovic, Jacek Kociszewski, Andrzej Kuszka, Julia Münst, Lilly Eisele, Nicole Viereck, Claudia Walser, Marianne Gamper, Volker Viereck
No abstract text is available yet for this article.
July 2017: Praxis
https://www.readbyqxmd.com/read/28738070/determinants-associated-with-deprivation-in-multimorbid-patients-in-primary-care-a-cross-sectional-study-in-switzerland
#19
Silja Leiser, Anouk Déruaz-Luyet, A Alexandra N'Goran, Jérôme Pasquier, Sven Streit, Stefan Neuner-Jehle, Andreas Zeller, Dagmar M Haller, Lilli Herzig, Patrick Bodenmann
BACKGROUND: Deprivation usually encompasses material, social, and health components. It has been shown to be associated with greater risks of developing chronic health conditions and of worse outcome in multimorbidity. The DipCare questionnaire, an instrument developed and validated in Switzerland for use in primary care, identifies patients subject to potentially higher levels of deprivation. OBJECTIVES: To identifying determinants of the material, social, and health profiles associated with deprivation in a sample of multimorbid, primary care patients, and thus set priorities in screening for deprivation in this population...
2017: PloS One
https://www.readbyqxmd.com/read/28737992/temporal-trends-in-use-of-biologic-dmards-for-rheumatoid-arthritis-in-the-united-states-a-cohort-study-of-publicly-and-privately-insured-patients
#20
Rishi J Desai, Daniel H Solomon, Yinzhu Jin, Jun Liu, Seoyoung C Kim
BACKGROUND: Ten biologic disease-modifying antirheumatic drugs (bDMARDs) are available as treatment for rheumatoid arthritis (RA), but relatively little is known about population-level time trends in the use of these agents. OBJECTIVE: To describe time trends in the use of bDMARDs in RA patients with private or public insurance in the United States. METHODS: Claims data from private (Optum Clinformatics, 2004-2015) and public (Medicaid Analytic eXtract [MAX], 2000-2010) insurance programs were used...
August 2017: Journal of Managed Care & Specialty Pharmacy
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