keyword
MENU ▼
Read by QxMD icon Read
search

Lilly

keyword
https://www.readbyqxmd.com/read/29231767/high-altitude-induced-alterations-in-gut-immune-axis-a-review
#1
Kunjan Khanna, K P Mishra, Lilly Ganju, Bhuvnesh Kumar, Shashi Bala Singh
High-altitude sojourn above 8000 ft is increasing day by day either for pilgrimage, mountaineering, holidaying or for strategic reasons. In India, soldiers are deployed to these high mountains for their duty or pilgrims visit to the holy places, which are located at very high altitude. A large population also resides permanently in high altitude regions. Every year thousands of pilgrims visit Holy cave of Shri Amarnath ji, which is above 15 000 ft. The poor acclimatization to high altitude may cause alteration in immunity...
December 12, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/29231253/internal-venous-anomalies-in-patients-with-a-genital-venous-malformation
#2
Caitlin M Peterman, Patricia S Todd, Anna P Lillis, Steven J Fishman, Marilyn G Liang
BACKGROUND: Cutaneous venous malformation (VM) can be associated with internal vascular anomalies. Our objective was to investigate the frequency of internal vascular anomalies in patients with an isolated genital venous malformation to assess the utility of screening for internal findings. METHODS: We retrospectively reviewed our Vascular Anomalies Center database for patients with a focal genital venous malformation presenting between 1999 and 2016. Abdominal and pelvic imaging reports were reviewed for internal vascular anomalies...
December 12, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29230381/exploring-process-variables-through-which-acceptance-based-behavioral-interventions-may-improve-weight-loss-maintenance
#3
J Lillis, J G Thomas, H M Niemeier, R R Wing
Objective: A previously published randomized trial with individuals reporting high internal disinhibition showed significant differences in post-treatment weight change favoring Acceptance-Based Behavioral Intervention (ABBI) when compared to standard behavioral treatment (SBT). This paper examines process variables that might contribute to the observed differences in weight change. Methods: Participants were 162 adults with overweight or obesity (mean BMI 37.6) randomly assigned to ABBI or SBT...
October 2017: Journal of Contextual Behavioral Science
https://www.readbyqxmd.com/read/29229219/computer-assisted-navigation-for-intramedullary-nail-fixation-of-intertrochanteric-femur-fractures-a-randomized-controlled-trial
#4
Ryan J Lilly, Denise M Koueiter, Kelly C Graner, Gregory P Nowinski, Jason Sadowski, Kevin D Grant
INTRODUCTION: Lag screw cutout is one of the most commonly reported complications following intramedullary nail fixation of intertrochanteric femur fractures. However, its occurrence can be minimized by a well-positioned implant, with a short Tip-to-Apex Distance (TAD). Computer-assisted navigation systems provide surgeons with the ability to track screw placement in real-time. This could allow for improved lag screw placement and potentially reduce radiation exposure to the patient and surgeon...
December 7, 2017: Injury
https://www.readbyqxmd.com/read/29228299/development-of-cell-penetrating-bispecific-antibodies-targeting-the-n-terminal-domain-of-androgen-receptor-for-prostate-cancer-therapy
#5
Nancy L Goicochea, Maria Garnovskaya, Mary G Blanton, Grace Chan, Richard Weisbart, Michael B Lilly
Castration-resistant prostate cancer cells exhibit continued androgen receptor signaling in spite of low levels of ligand. Current therapies to block androgen receptor signaling act by inhibiting ligand production or binding. We developed bispecific antibodies capable of penetrating cells and binding androgen receptor outside of the ligand-binding domain. Half of the bispecific antibody molecule consists of a single-chain variable fragment of 3E10, an anti-DNA antibody that enters cells. The other half is a single-chain variable fragment version of AR441, an anti-AR antibody...
December 6, 2017: Protein Engineering, Design & Selection: PEDS
https://www.readbyqxmd.com/read/29221794/glp-1-action-in-the-mouse-bed-nucleus-of-the-stria-terminalis
#6
Diana L Williams, Nicole A Lilly, Ian J Edwards, Pallas Yao, James E Richards, Stefan Trapp
Glucagon-like peptide-1 (GLP-1) injected into the brain reduces food intake. Similarly, activation of preproglucagon (PPG) cells in the hindbrain which synthesize GLP-1, reduces food intake. However, it is far from clear whether this happens because of satiety, nausea, reduced reward, or even stress. Here we explore the role of the bed nucleus of the stria terminalis (BNST), an area involved in feeding control as well as stress responses, in GLP-1 responses. Using cre-expressing mice we visualized projections of NTS PPG neurons and GLP-1R-expressing BNST cells with AAV-driven Channelrhodopsin-YFP expression...
December 5, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29218689/preliminary-results-of-a-3d-printed-acetabular-component-in-the-management-of-extensive-defects
#7
Mustafa Citak, Lilly Kochsiek, Thorsten Gehrke, Carl Haasper, Eduardo M Suero, Hans Mau
INTRODUCTION: The treatment of extensive bone loss and massive acetabular defects can be compounded by several challenges and pitfalls. The survivorship following acetabular revision with extensive bone loss is still unsatisfactory. The goal of the present study was to analyse the outcomes of 3D-printed patient-specific acetabular components in the management of extensive acetabular defects and combined pelvic discontinuity (PD). METHODS: 9 patients underwent revision THA using 3D-printed custom acetabular components to reconstruct extensive acetabular defects...
December 4, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29216806/an-industry-update-the-latest-developments-in-therapeutic-delivery
#8
Iain Simpson
This industry update covers the period from 1 September through 30 September 2017, and is based on information sourced from company press releases, scientific literature, patents and various news websites. The month saw the US FDA approve three new molecular entities, Aliqopa (copanlisib dihydrochloride) (Bayer Healthcare); Solosec (secnidazole) (Symbiomix Therapeutics) and Verzenio (abemaciclib) (Eli Lilly and Co). Intarcia Therapeutics Inc. has its application for approval of a novel drug device combination of exenatide for the treatment of diabetes rejected by FDA but said that it will work to address the concerns and refile the application...
January 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/29206489/continuous-flow-technology-vs-the-batch-by-batch-approach-to-produce-pharmaceutical-compounds
#9
Kevin P Cole, Martin D Johnson
For the manufacture of small molecule drugs, many pharmaceutical innovator companies have recently invested in continuous processing, which can offer significant technical and economic advantages over traditional batch methodology. This Expert Review will describe the reasons for this interest as well as many considerations and challenges that exist today concerning continuous manufacturing. Areas Covered: Continuous processing is defined and many reasons for its adoption are described. The current state of continuous drug substance manufacturing within the pharmaceutical industry is summarized...
December 5, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/29206004/outcomes-of-endovascular-aortic-repair-in-the-modern-era
#10
Jacob Budtz-Lilly, Anders Wanhainen, Kevin Mani
Monitoring outcomes following endovascular aortic repair (EVAR) is critical. Although evidence from randomized controlled trials has solidified the role of EVAR, the analysis of outcomes and "real-world" data has uncovered limitations, improved the selection of appropriate patients, and underscored the importance of instructions for use. Subsequent studies demonstrated the learning curve of EVAR and gradual improvement of outcomes over time. Outcomes analyses will continue to play an important role, particularly as technological growth of endovascular therapy has enabled treatment of more complex aneurysm pathologies and patients...
December 4, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29204894/the-development-of-the-genital-psoriasis-sexual-frequency-questionnaire-genps-sfq-to-assess-the-impact-of-genital-psoriasis-on-sexual-health
#11
Alice B Gottlieb, Brian Kirby, Caitriona Ryan, April N Naegeli, Russel Burge, Alison Potts Bleakman, Milena D Anatchkova, Jennifer Cather
INTRODUCTION: Patient-reported outcome measures (PROs) exist for psoriasis but not genital psoriasis (GenPs). METHODS: This cross-sectional, qualitative study in patients with moderate-to-severe GenPs was conducted to support development of a PRO for measuring the impact of GenPs on sexual activity and to establish content validity. The impacts of GenPs were identified in a literature review. Findings from the literature review were discussed with clinicians, and then patients with GenPs were interviewed...
December 4, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29204893/the-development-of-a-patient-reported-outcome-measure-for-assessment-of-genital-psoriasis-symptoms-the-genital-psoriasis-symptoms-scale-gpss
#12
Alice B Gottlieb, Brian Kirby, Caitriona Ryan, April N Naegeli, Russel Burge, Alison Potts Bleakman, Milena D Anatchkova, Gil Yosipovitch
INTRODUCTION: Patient-reported outcome measures (PROs) specific for genital psoriasis (GenPs) have not been described. METHODS: In this cross-sectional, qualitative study in patients with moderate-to-severe GenPs, we sought to develop a PRO useful for GenPs symptom assessment. A literature review was performed to identify relevant psoriasis or GenPs symptoms and existing PROs that may be useful in the evaluation of symptom severity in GenPs patients. The literature review findings were discussed with clinicians, and then patients with GenPs...
December 4, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29204220/impact-of-post-exodontia-bleeding-in-cardiovascular-patients-a-new-classification-proposal
#13
REVIEW
T Lillis, M Didagelos, L Lillis, C Theodoridis, H Karvounis, A Ziakas
Background: Exodontia (dental extraction), being the most frequent minor surgical procedure in the general population, inevitably involves a large number of patients on antithrombotic medication. Current experience shows that there is a degree of confusion in managing these patients. Description: Post-exodontia bleeding, a natural consequence of every dental extraction with no or minor clinical significance in the vast majority of cases, often appears to be of major concern to both patients and healthcare practitioners (dentists or physicians), either because of the alarming nature of oral bleeding itself or because of the distorted perception about its importance...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/29195442/sound-production-patterns-of-big-clawed-snapping-shrimp-alpheus-spp-are-influenced-by-time-of-day-and-social-context
#14
Ashlee Lillis, Jessica N Perelman, Apryle Panyi, T Aran Mooney
Snapping shrimp are perhaps the most pervasive sources of biological sound in the ocean. The snapping sounds of cryptic shrimp colonies in shallow coastal habitats worldwide create a near-continuous crackling with high spatiotemporal variability, yet the underlying acoustic ecology is not well understood. This study investigated sound production rates and acoustic behavior of snapping shrimp species common in the Western Atlantic Ocean and Gulf of Mexico (Alpheus heterochaelis and Alpheus angulosus). Snap rates were measured in a controlled laboratory setting under natural light, temperature, and substrate conditions for shrimp held individually, in pairs, and in a ten-shrimp mesocosm, to test hypotheses that acoustic activity varies with time-of-day and social context...
November 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29189347/the-glucagon-like-peptide-1-analog-exenatide-increases-blood-glucose-clearance-lactate-clearance-and-heart-rate-in-comatose-patients-after-out-of-hospital-cardiac-arrest
#15
Sebastian Wiberg, Jesper Kjaergaard, Henrik Schmidt, Jakob Hartvig Thomsen, Martin Frydland, Matilde Winther-Jensen, Matias Greve Lindholm, Dan Eik Høfsten, Thomas Engstrøm, Lars Køber, Jacob Eifer Møller, Christian Hassager
OBJECTIVES: To investigate the effects of the glucagon-like peptide-1 analog exenatide on blood glucose, lactate clearance, and hemodynamic variables in comatose, resuscitated out-of-hospital cardiac arrest patients. DESIGN: Predefined post hoc analyzes from a double-blind, randomized clinical trial. SETTING: The ICU of a tertiary heart center. PATIENTS: Consecutive sample of adult, comatose patients undergoing targeted temperature management after out-of-hospital cardiac arrest from a presumed cardiac cause, irrespective of the initial cardiac rhythm...
November 20, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29186677/the-methyltransferase-setd8-is-essential-for-erythroblast-survival-and-maturation
#16
Jeffrey Malik, Jacquelyn A Lillis, Tyler Couch, Michael Getman, Laurie A Steiner
Erythropoiesis is a highly regulated process that generates enucleate red blood cells from committed erythroid progenitors. Chromatin condensation culminating in enucleation is a defining feature of this process. Setd8 is the sole enzyme that can mono-methylate histone H4, lysine 20 and is highly expressed in erythroblasts compared to most other cell types. Erythroid Setd8 deletion results in embryonic lethality from severe anemia due to impaired erythroblast survival and proliferation. Setd8 protein levels are also uniquely regulated in erythroblasts, suggesting a cell-type-specific role for Setd8 during terminal maturation...
November 28, 2017: Cell Reports
https://www.readbyqxmd.com/read/29172978/application-of-the-fda-biosimilar-extrapolation-framework-to-make-off-label-determinations
#17
Edward Li, Ernesto Lobaina
BACKGROUND: The FDA's extrapolation framework allows for a biosimilar to obtain licensure for indications that were not explicitly studied in the context of a clinical trial by extending conclusions from studies in 1 population to make inferences in other populations. Within routine clinical care, drugs and biologics are routinely used for medically accepted off-label indications. The appropriateness of these products for off-label indications are typically curated by compendia and guidelines, which have established processes and criteria for reviewing and evaluating the evidence to make such determinations...
December 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29172606/ecological-momentary-assessment-of-self-attitudes-in-response-to-dietary-lapses
#18
Leah M Schumacher, Gerald J Martin, Stephanie P Goldstein, Stephanie M Manasse, Ross D Crosby, Meghan L Butryn, Jason Lillis, Evan M Forman
OBJECTIVE: To examine whether self-attitudes and self-efficacy after dietary lapses relate to lapse frequency or predict risk for lapsing again on the same day. METHOD: Adults with overweight/obesity (n = 91) completed ecological momentary assessment for 14 days at the start of a lifestyle modification program. At each survey, participants reported whether they had experienced a dietary lapse, and, if so, reported their self-attitudes (i.e., self-criticism, self-forgiveness, self-regard) and self-efficacy...
November 27, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/29169877/cetuximab-plus-carboplatin-and-paclitaxel-with-or-without-bevacizumab-versus-carboplatin-and-paclitaxel-with-or-without-bevacizumab-in-advanced-nsclc-swog-s0819-a-randomised-phase-3-study
#19
Roy S Herbst, Mary W Redman, Edward S Kim, Thomas J Semrad, Lyudmila Bazhenova, Gregory Masters, Kurt Oettel, Perry Guaglianone, Christopher Reynolds, Anand Karnad, Susanne M Arnold, Marileila Varella-Garcia, James Moon, Philip C Mack, Charles D Blanke, Fred R Hirsch, Karen Kelly, David R Gandara
BACKGROUND: EGFR antibodies have shown promise in patients with advanced non-small-cell lung cancer (NSCLC), particularly with squamous cell histology. We hypothesised that EGFR copy number by fluorescence in-situ hybridisation (FISH) can identify patients most likely to benefit from these drugs combined with chemotherapy and we aimed to explore the activity of cetuximab with chemotherapy in patients with advanced NSCLC who are EGFR FISH-positive. METHODS: We did this open-label, phase 3 study (SWOG S0819) at 277 sites in the USA and Mexico...
November 20, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29164970/a-feasibility-study-of-trauma-sensitive-obstetric-care-for-low-income-ethno-racial-minority-pregnant-abuse-survivors
#20
N R Stevens, T A Lillis, L Wagner, V Tirone, S E Hobfoll
PURPOSE: This study evaluated the feasibility and acceptability of an integrated (psychological and obstetric) intervention for pregnant abuse survivors with posttraumatic stress symptoms (PTS) from low-income, ethno-racial minority backgrounds. METHODS: Trauma-sensitive obstetrics to promote control, anxiety-reduction and empowerment (TO-CARE) offers cognitive-behavioral therapy (CBT) coping skills delivered over six sessions by therapists, coupled with trauma-sensitive obstetric care from specially-trained obstetric physicians...
November 22, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
keyword
keyword
4171
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"