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https://www.readbyqxmd.com/read/27915481/effects-of-combination-treatment-of-alpha-1-adrenergic-receptor-antagonists-on-voiding-dysfunction-study-on-target-organs-in-overactive-bladder-rats
#1
Il Gyu Ko, Bo Min Moon, Sung Eun Kim, Jun Jang Jin, Lakkyong Hwang, Eun Sang Ji, Chang Ju Kim, Tai Hyung Kim, Hyun Hee Choi, Kyung Jin Chung
PURPOSE: Overactive bladder (OAB) causes urinary urgency, usually accompanied by frequency and nocturia. Alpha 1-adrenergic receptor (α1-AR) antagonists are known to improve lower urinary tract symptoms associated with OAB. The α1-AR antagonists constitute a variety of drugs according to the receptor subtype affinity. This study investigated the efficacy of tamsulosin, naftopidil, and a combination of the two on OAB rats. METHODS: The OAB rat model was induced by an intraperitoneal injection of cyclophosphamide for 14 days...
November 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27915476/translational-research-for-pediatric-lower-urinary-tract-dysfunction
#2
REVIEW
Akihiro Kanematsu
This review provides a comprehensive view of translational research aimed at elucidating the pathophysiology of pediatric lower urinary tract dysfunction (LUTD). A web search was conducted according to combinations of keywords, and the significance of each article was defined by the author. The dramatic evolution of the mass analysis method of genomes, transcripts, and proteins has enabled a comprehensive analysis of molecular events underlying diseases, and these methodologies have also been applied to pediatric LUTD...
November 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27915460/zinc-supplementation-for-the-prevention-of-pneumonia-in-children-aged-2-months-to-59-months
#3
REVIEW
Zohra S Lassi, Anoosh Moin, Zulfiqar A Bhutta
BACKGROUND: Pneumonia is a leading cause of morbidity and mortality in children younger than five years of age. Most deaths occur during infancy and in low-income countries. Daily zinc supplements have been reported to prevent acute lower respiratory tract infection (LRTI) and reduce child mortality. This is an update of a review first published in 2010. OBJECTIVES: To evaluate the effectiveness of zinc supplementation in the prevention of pneumonia in children aged two to 59 months...
December 4, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27915446/superior-dislocation-of-the-patella-a-pathognomonic-finding-and-review-of-literature
#4
P W van Egmond, M C Vermeulen, C F van Dijke, H C A Graat
A 59-year-old woman with a painful right knee that became locked in extension after a trivial trauma was seen at the emergency room. This was caused by unloaded hyperextension in bed. She was diagnosed with a superior dislocation of the patella. A closed reduction was performed, but a recurrent episode was seen within a week. An arthroscopy was performed, in which the causative osteophytes were removed. In the 12-month follow-up after treatment, no recurrence was seen. A superior dislocation of the patella is caused by patellofemoral osteophytes that interlock...
December 3, 2016: Skeletal Radiology
https://www.readbyqxmd.com/read/27915443/successful-combination-of-endoscopic-pyloromyotomy-and-balloon-dilatation-for-hypertrophic-pyloric-stenosis-in-an-older-child-a-novel-procedure
#5
Satoshi Yokoyama, Shiro Uyama, Hiroyoshi Iwagami, Yukitaka Yamashita
BACKGROUND: Hypertrophic pyloric stenosis (HPS) is a rare cause of gastric outlet obstruction beyond infancy. Ramstedt pyloromyotomy remains the gold standard treatment for HPS. This type of HPS can be managed successfully with pyloromyotomy under laparoscopic or open procedures. Endoscopic pyloric balloon dilation (EPBD) has not been recommended in the treatment of HPS, and there are only a small number of reported cases who had had successful endoscopic pyloromyotomy (EP) for HPS only in infants...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27915441/ovarian-metastasis-from-uveal-melanoma-with-mlh1-pms2-protein-loss-in-a-patient-with-germline-mlh1-mutated-lynch-syndrome-consequence-or-coincidence
#6
João Lobo, Carla Pinto, Micaela Freitas, Manuela Pinheiro, Rámon Vizcaino, Esther Oliva, Manuel R Teixeira, Carmen Jerónimo, Carla Bartosch
Currently, uveal melanoma is not considered within the Lynch syndrome tumor spectrum. However, there are studies suggesting a contribution of microsatellite instability in sporadic uveal melanoma tumorigenesis. We report a 45-year-old woman who was referred for genetic counseling due to a family history of Lynch syndrome caused by a MLH1 mutation. She originally underwent enucleation of the right eye secondary to a uveal spindle cell melanoma diagnosed at age 25. The tumor recurred 22 years later presenting as an ovarian metastasis and concurrently a microscopic endometrial endometrioid carcinoma, grade 1/3 was diagnosed...
December 3, 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27915435/bone-remodeling-and-regulating-biomarkers-in-women-at-the-time-of-breast-cancer-diagnosis
#7
Song Yao, Yali Zhang, Li Tang, Janise M Roh, Cecile A Laurent, Chi-Chen Hong, Theresa Hahn, Joan C Lo, Christine B Ambrosone, Lawrence H Kushi, Marilyn L Kwan
PURPOSE: The majority of breast cancer patients receive endocrine therapy, including aromatase inhibitors known to cause increased bone resorption. Bone-related biomarkers at the time of breast cancer diagnosis may predict future risk of osteoporosis and fracture after endocrine therapy. METHODS: In a large population of 2,401 female breast cancer patients who later underwent endocrine therapy, we measured two bone remodeling biomarkers, TRAP5b and BAP, and two bone regulating biomarkers, RANKL and OPG, in serum samples collected at the time of breast cancer diagnosis...
December 3, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27915431/time-dependent-postmortem-redistribution-of-morphine-and-its-metabolites-in-blood-and-alternative-matrices-application-of-ct-guided-biopsy-sampling
#8
Sandra N Staeheli, Dominic Gascho, Lars C Ebert, Thomas Kraemer, Andrea E Steuer
Interpretation of postmortem morphine concentrations in forensic toxicology provides several pitfalls such as missing information on tolerance, analyte stability, or postmortem redistribution (PMR). Recently, it had been shown that computed tomography (CT)-guided collection of biopsies using a robotic arm (virtobot) provides a valuable strategy for systematic studies on time-dependent PMR. Using this technique, time-dependent PMR of morphine and its metabolites was investigated in 12 cases. At admission to the institute (t1), femoral and heart blood (right ventricle) as well as biopsies from the right lung, the right kidney, liver, spleen, and muscle tissue were collected...
December 3, 2016: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27915421/the-frequency-and-treatment-of-pneumothorax-associated-with-pulmonary-nontuberculous-mycobacterial-infection
#9
Masaki Ikeda, Koji Takahashi, Teruya Komatsu, Toru Tanaka, Tatsuo Kato, Takuji Fujinaga
OBJECTIVES: Characteristics of pneumothorax associated with nontuberculous mycobacterium (NTM) infection are rarely reported, especially in terms of surgical treatments. Our objectives were to show the tendency and clinical courses of pneumothorax due to NTM and discuss the way of therapy in our hospital. METHODS: We retrospectively analyzed 557 patients with NTM infection over a period of 5 years at the Nagara Medical Center. RESULTS: A total of 12 out of the 557 patients (2...
December 3, 2016: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27915419/necrotizing-meningoencephalitis-caused-by-sarcocystis-falcatula-in-bare-faced-ibis-phimosus-infuscatus
#10
Guilherme Konradt, Matheus Viezzer Bianchi, Ronaldo Viana Leite-Filho, Bruna Zafalon da Silva, Rodrigo Martins Soares, Saulo Petinatti Pavarini, David Driemeier
The infection by S. falcatula is commonly associated with respiratory disease in captive psittacine birds, with a few case reports of this protozoan causing encephalitis in wild birds. We describe the clinical, pathological, and molecular aspects of an infection by S. falcatula in a bare-faced ibis (Phimosus infuscatus). Clinically, wing paralysis and mild motor incoordination were observed. At necropsy, the telencephalic cortex showed multifocal to coalescing yellowish soft areas. Histologically, multifocal to coalescent nonsuppurative necrotizing meningoencephalitis of telencephalic cortex, cerebellum, and brainstem was observed...
December 3, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27915418/in-vivo-cns-infection-model-of-acanthamoeba-genotype-t4-the-early-stages-of-infection-lack-presence-of-host-inflammatory-response-and-are-a-slow-and-contact-dependent-process
#11
Maritza Omaña-Molina, Dolores Hernandez-Martinez, Raquel Sanchez-Rocha, Ulises Cardenas-Lemus, Citlaltepetl Salinas-Lara, Adolfo Rene Mendez-Cruz, Laura Colin-Barenque, Patricia Aley-Medina, Jesus Espinosa-Villanueva, Leticia Moreno-Fierros, Jacob Lorenzo-Morales
This study was developed in order to describe the early morphological events observed during the invasion of two pathogenic strains of Acanthamoeba (genotype T4); A. castellanii and A. culbertsoni, at the olfactory meatus and cerebral, pulmonary, renal, hepatic and splenic tissues levels, an in vivo invasion study. Histological and immunohistochemical description of the events at 24, 48, 72, and 96 h postintranasal inoculations of BALB/c mice was performed. A. castellanii showed a higher invasion rate than A...
December 3, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27915414/brownification-increases-winter-mortality-in-fish
#12
Per Hedström, David Bystedt, Jan Karlsson, Folmer Bokma, Pär Byström
In northern climates, winter is a bottleneck for many organisms. Low light and resource availability constrains individual foraging rates, potentially leading to starvation and increased mortality. Increasing input of humic substances to aquatic ecosystems causes brownification of water and hence a further decrease of light availability, which may lead to further decreased foraging rates and starvation mortality during winter. To test this hypothesis, we measured the effects of experimentally increased humic water input on consumption and survival of young-of-the-year three-spined stickleback (Gasterosteus aculeatus) over winter in large outdoor enclosures...
December 3, 2016: Oecologia
https://www.readbyqxmd.com/read/27915383/a-covalent-antagonist-for-the-human-adenosine-a2a-receptor
#13
Xue Yang, Guo Dong, Thomas J M Michiels, Eelke B Lenselink, Laura Heitman, Julien Louvel, Ad P IJzerman
The structure of the human A2A adenosine receptor has been elucidated by X-ray crystallography with a high affinity non-xanthine antagonist, ZM241385, bound to it. This template molecule served as a starting point for the incorporation of reactive moieties that cause the ligand to covalently bind to the receptor. In particular, we incorporated a fluorosulfonyl moiety onto ZM241385, which yielded LUF7445 (4-((3-((7-amino-2-(furan-2-yl)-[1, 2, 4]triazolo[1,5-a][1, 3, 5]triazin-5-yl)amino)propyl)carbamoyl)benzene sulfonyl fluoride)...
December 3, 2016: Purinergic Signalling
https://www.readbyqxmd.com/read/27915339/clinicopathological-features-and-predictive-factors-for-colorectal-cancer-outcome-in-the-kingdom-of-saudi-arabia
#14
Abdurrahman Aldiab, Khayal A Al Khayal, Omar A Al Obaid, Ahmed Alsheikh, Khalid Alsaleh, Mohamed Shahid, Hana Alkharji
BACKGROUND/AIMS: Colorectal cancer (CRC) is the most frequent cancer and a leading cause of cancer death in the Kingdom of Saudi Arabia (KSA). To date, no nationwide screening programs have been adopted. This prospective, longitudinal study investigated factors influencing the outcome of CRC in Saudi patients. METHODS: Patients completed a CRC awareness questionnaire. Colonoscopy, CT/MRI, histopathology of tumor biopsies, and KRAS and BRAF testing were performed...
December 3, 2016: Oncology
https://www.readbyqxmd.com/read/27915337/quercetin-assists-fluconazole-to-inhibit-biofilm-formations-of-fluconazole-resistant-candida-albicans-in-in-vitro-and-in-vivo-antifungal-managements-of-vulvovaginal-candidiasis
#15
Mei Gao, Hui Wang, LiJuan Zhu
BACKGROUND: Vulvovaginal candidiasis (VVC) is a common gynecological disease. Candida albicans is believed to be mainly implicated in VVC occurrence, the biofilm of which is one of the virulence factors responsible for resistance to traditional antifungal agents especially to fluconazole (FCZ). Quercetin (QCT) is a dietary flavonoid and has been demonstrated to be antifungal against C. albicans biofilm. METHODS: 17 C. albicans isolates including 15 clinical ones isolated from VVC patients were employed to investigate the effects of QCT and/or FCZ on the inhibition of C...
November 30, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27915322/ocular-morbidity-associated-with-retinopathy-of-prematurity-in-treated-and-untreated-eyes-a-review-of-the-literature-and-data-from-a-tertiary-eye-care-center-in-southern-india
#16
Perumalsamy Vijayalakshmi, Tulika Kara, Clare Gilbert
Retinopathy of prematurity (ROP) is an emerging cause of childhood blindness in low- and middle-income countries. We review the magnitude, causes, prevention and treatment of visual impairment caused by ROP over a time span. A review of literature on short and long term structural and functional outcomes of ROP was conducted through PubMed search primarily focusing on studies published during the last decade. Additionally, we have shared data from our institute located in Southern India. Visual Impairment in ROP-treated children ranged from 4...
November 7, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27915321/anti-vascular-endothelial-growth-factor-preparations-in-the-treatment-of-retinopathy-of-prematurity-balancing-risks-and-benefits
#17
Deepak Chawla, Brian A Darlow
NEED AND PURPOSE OF REVIEW: The standard of management of severe retinopathy of prematurity (ROP) is laser ablation of the peripheral retina. Intra-vitreal injection of anti- vascular endothelial growth factor antibodies has emerged as an alternative modality of treatment of ROP. The purpose of this review is to evaluate the current evidence on benefits and risks of using anti-VEGF antibodies for management of ROP. METHODS: PubMed and Cochrane Register of Clinical Trials were searched for studies evaluating role of anti-VEGF agents in ROP...
November 7, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27915320/retinopathy-of-prematurity-aiims-new-delhi-experience
#18
Sindhu Sivanandan, Parijat Chandra, Ashok K Deorari, Ramesh Agarwal
Retinopathy of prematurity (ROP) is a leading cause of potentially avoidable childhood blindness worldwide. With improvement in neonatal care, more preterm infants are surviving with a resultant increase in the number of ROP cases. In low-middle income countries, the disease epidemiology is characterized by the occurrence of ROP at higher birthweight in premature babies with greater severity at presentation. In this article, we describe the ROP screening and management program at the All India Institute of Medical Sciences (AIIMS), New Delhi that has evolved over last three decades...
November 7, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27915319/retinopathy-of-prematurity-clinical-features-classification-natural-history-management-and-outcome
#19
Parag K Shah, Vishma Prabhu, Ratnesh Ranjan, Venkatapathy Narendran, Narendran Kalpana
CONTEXT: Retinopathy of prematurity is an avoidable cause of childhood blindness. Proper understanding of the classification and treatment methods is a must in tackling this disease. EVIDENCE ACQUISITION: Literature search with PubMed was conducted covering the period 1940-2015 with regards to retinopathy of prematurity, retrolental fibroplasia, its natural history, classification and treatment. RESULTS: The clinical features, screening and staging of retinopathy of prematurity according to International classification of retinopathy of prematurity (ICROP) has been included with illustrations...
November 7, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27915316/lack-of-screening-underlies-most-stage-5-retinopathy-of-prematurity-among-cases-presenting-to-a-tertiary-eye-center-in-india
#20
Rajvardhan Azad, Parijat Chandra, Anil Gangwe, Vivek Kumar
OBJECTIVE: To study the barriers to effective screening, early detection and treatment of Retinopathy of Prematurity leading to advanced disease. DESIGN: Cross-sectional study. SETTING: Tertiary eye care hospital in northern India. PARTICIPANTS: 115 babies with bilateral stage 5 ROP identified amongst 354 preterm infants examined over a one year period. METHODS: Information regarding gestational age, birthweight, duration of stay in nursery, duration of supplemental oxygen therapy and treatment details were obtained from discharge summary when available, and by interviewing carers...
November 7, 2016: Indian Pediatrics
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