keyword
MENU ▼
Read by QxMD icon Read
search

Neuroscience neurobiology

keyword
https://www.readbyqxmd.com/read/28341151/mice-heterozygous-for-an-inactivated-allele-of-the-schizophrenia-associated-brd1-gene-display-selective-cognitive-deficits-with-translational-relevance-to-schizophrenia
#1
Per Qvist, Anto P Rajkumar, John P Redrobe, Mette Nyegaard, Jane H Christensen, Ole Mors, Gregers Wegener, Michael Didriksen, Anders D Børglum
Schizophrenia is a debilitating brain disorder characterized by disturbances of emotion, perception and cognition. Cognitive impairments predict functional outcome in schizophrenia and are detectable even in the prodromal stage of the disorder. However, our understanding of the underlying neurobiology is limited and procognitive treatments remain elusive. We recently demonstrated that mice heterozygous for an inactivated allele of the schizophrenia-associated Brd1 gene (Brd1(+/-) mice) display behaviors reminiscent of schizophrenia, including impaired social cognition and long-term memory...
March 21, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28329204/new-neuroscience-tools-that-are-identifying-the-sleep-wake-circuit
#2
Priyattam J Shiromani, John H Peever
The complexity of the brain is yielding to technology. In the area of sleep neurobiology, conventional neuroscience tools such as lesions, cell recordings, c-Fos, and axon-tracing methodologies have been instrumental in identifying the complex and intermingled populations of sleep- and arousal-promoting neurons that orchestrate and generate wakefulness, NREM, and REM sleep. In the last decade, new technologies such as optogenetics, chemogenetics and the CRISPR-Cas system have begun to transform how biologists understand the finer details associated with sleep-wake regulation...
March 1, 2017: Sleep
https://www.readbyqxmd.com/read/28324757/perceptual-category-learning-and-visual-processing-an-exercise-in-computational-cognitive-neuroscience
#3
George Cantwell, Maximilian Riesenhuber, Jessica L Roeder, F Gregory Ashby
The field of computational cognitive neuroscience (CCN) builds and tests neurobiologically detailed computational models that account for both behavioral and neuroscience data. This article leverages a key advantage of CCN-namely, that it should be possible to interface different CCN models in a plug-and-play fashion-to produce a new and biologically detailed model of perceptual category learning. The new model was created from two existing CCN models: the HMAX model of visual object processing and the COVIS model of category learning...
March 6, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28321194/mindfulness-and-emotion-regulation-insights-from-neurobiological-psychological-and-clinical-studies
#4
REVIEW
Simón Guendelman, Sebastián Medeiros, Hagen Rampes
There is increasing interest in the beneficial clinical effects of mindfulness-based interventions (MBIs). Research has demonstrated their efficacy in a wide range of psychological conditions characterized by emotion dysregulation. Neuroimaging studies have evidenced functional and structural changes in a myriad of brain regions mainly involved in attention systems, emotion regulation, and self-referential processing. In this article we review studies on psychological and neurobiological correlates across different empirically derived models of research, including dispositional mindfulness, mindfulness induction, MBIs, and expert meditators in relation to emotion regulation...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28283392/addictions-neuroclinical-assessment-a-reverse-translational-approach
#5
REVIEW
Laura E Kwako, Reza Momenan, Erica N Grodin, Raye Z Litten, David Goldman
Incentive salience, negative emotionality, and executive function are functional domains that are etiologic in the initiation and progression of addictive disorders, having been implicated in humans with addictive disorders and in animal models of addictions. Measures of these three neuroscience-based functional domains can capture much of the effects of inheritance and early exposures that lead to trait vulnerability shared across different addictive disorders. For specific addictive disorders, these measures can be supplemented by agent specific measures such as those that access pharmacodynamic and pharmacokinetic variation attributable to agent-specific gatekeeper molecules including receptors and drug-metabolizing enzymes...
March 7, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28259799/gray-and-white-matter-correlates-of-the-big-five-personality-traits
#6
Jesús Privado, Francisco J Román, Carlota Saénz-Urturi, Miguel Burgaleta, Roberto Colom
Personality neuroscience defines the scientific study of the neurobiological basis of personality. This field assumes that individual differences in personality traits are related with structural and functional variations of the human brain. Gray and white matters are structural properties considered separately in previous research. Available findings in this regard are largely disparate. Here we analyze the relationships between gray matter (cortical thickness (CT), cortical surface area (CSA), and cortical volume) and integrity scores obtained after several white matter tracts connecting different brain regions, with individual differences in the personality traits comprised by the Five-Factor Model (extraversion, agreeableness, conscientiousness, neuroticism, and openness to experience)...
March 1, 2017: Neuroscience
https://www.readbyqxmd.com/read/28230844/network-neuroscience
#7
REVIEW
Danielle S Bassett, Olaf Sporns
Despite substantial recent progress, our understanding of the principles and mechanisms underlying complex brain function and cognition remains incomplete. Network neuroscience proposes to tackle these enduring challenges. Approaching brain structure and function from an explicitly integrative perspective, network neuroscience pursues new ways to map, record, analyze and model the elements and interactions of neurobiological systems. Two parallel trends drive the approach: the availability of new empirical tools to create comprehensive maps and record dynamic patterns among molecules, neurons, brain areas and social systems; and the theoretical framework and computational tools of modern network science...
February 23, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28228081/the-neurobiology-and-psychiatric-perspective-of-vaginismus-linking-the-pharmacological-and-psycho-social-interventions
#8
Zuri Shahidii Kadir, Hatta Sidi, Jaya Kumar, Srijit Das, Marhani Midin, Najwa Baharuddin
Vaginismus is an involuntary muscle contraction of the outer third of vaginal barrel causing sexual penetration almost impossible. It is generally classified under sexual pain disorder (SPD). In Diagnostic and Statistical Manual, 5th edition, it is classified under the new rubric of Genito-Pelvic Pain/Sexual Penetration Disorder. This fear-avoidance condition poses an ongoing significant challenge to the medical and health professionals due to the very demanding needs in health care despite its unpredictable prognosis...
February 22, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28224686/addiction-research-and-theory-a-commentary-on-the-surgeon-general-s-report-on-alcohol-drugs-and-health
#9
Aldo Badiani, Kent C Berridge, Markus Heilig, David J Nutt, Terry E Robinson
The Office of the Surgeon General recently produced its first Report on the consequences of alcohol and drug abuse on health, making several very laudable policy recommendations. The Report also emphasizes the importance of adequate funding for biomedical research, which is good news for both researchers and patients. However, the Report is marred by a biased viewpoint on the psychology and neurobiology of drug addiction. We highlight here four controversial issues that were depicted as facts in the Report, thereby potentially misleading non-expert readers about the current state-of-the-art understanding of the psychology and neurobiology of drug addiction...
February 21, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28221003/trends-in-high-throughput-and-functional-neuroimaging-in-caenorhabditis-elegans
#10
REVIEW
Yongmin Cho, Charles L Zhao, Hang Lu
The nervous system of Caenorhabditis elegans is an important model system for understanding the development and function of larger, more complex nervous systems. It is prized for its ease of handling, rapid life cycle, and stereotyped, well-cataloged development, with the development of all 302 neurons mapped all the way from zygote to adult. The combination of easy genetic manipulation and optical transparency of the worm allows for the direct imaging of its interior with fluorescent microscopy, without physically compromising the normal physiology of the animal itself...
February 21, 2017: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/28214131/social-decision-making-and-the-brain-a-comparative-perspective
#11
REVIEW
Sébastien Tremblay, K M Sharika, Michael L Platt
The capacity and motivation to be social is a key component of the human adaptive behavioral repertoire. Recent research has identified social behaviors remarkably similar to our own in other animals, including empathy, consolation, cooperation, and strategic deception. Moreover, neurobiological studies in humans, nonhuman primates, and rodents have identified shared brain structures (the so-called 'social brain') apparently specialized to mediate such functions. Neuromodulators may regulate social interactions by 'tuning' the social brain, with important implications for treating social impairments...
February 14, 2017: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/28210202/mechanisms-and-effects-of-transcranial-direct-current-stimulation
#12
James Giordano, Marom Bikson, Emily S Kappenman, Vincent P Clark, H Branch Coslett, Michael R Hamblin, Roy Hamilton, Ryan Jankord, Walter J Kozumbo, R Andrew McKinley, Michael A Nitsche, J Patrick Reilly, Jessica Richardson, Rachel Wurzman, Edward Calabrese
The US Air Force Office of Scientific Research convened a meeting of researchers in the fields of neuroscience, psychology, engineering, and medicine to discuss most pressing issues facing ongoing research in the field of transcranial direct current stimulation (tDCS) and related techniques. In this study, we present opinions prepared by participants of the meeting, focusing on the most promising areas of research, immediate and future goals for the field, and the potential for hormesis theory to inform tDCS research...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28181877/an-in-silico-biomarker-based-method-for-the-evaluation-of-virtual-neuropsychiatric-drug-effects
#13
Peter J Siekmeier
The recent explosion in neuroscience research has markedly increased our understanding of the neurobiological correlates of many psychiatric illnesses, but this has unfortunately not translated into more effective pharmacologic treatments for these conditions. At the same time, researchers have increasingly sought out biological markers, or biomarkers, as a way to categorize psychiatric illness, as these are felt to be closer to underlying genetic and neurobiological vulnerabilities. While biomarker-based drug discovery approaches have tended to employ in vivo (e...
April 2017: Neural Computation
https://www.readbyqxmd.com/read/28178034/the-neurobiology-of-health-communication
#14
Peter A Hall, Kirk I Erickson, Peter J Gianaros
This issue of Psychosomatic Medicine describes findings from an innovative study by Kang et al. employing neuroimaging methods to quantify neural responses to health communications. Findings indicated that those sedentary individuals who hold self-transcendent values show attenuated limbic threat responses to communications about the benefits of physical activity. Furthermore, participants who were instructed to articulate such values showed some evidence of additional blunting of the same neural response. In this editorial we provide context for the interpretation of these findings within the existing research using the brain-as-predictor approach, and other recent trends within biobehavioral medicine involving the use of neuroscience methods in the service of health behavior change...
February 7, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28169519/monitoring-molecules-in-neuroscience-then-and-now
#15
Margaret E Rice
The 16th International Conference on Monitoring Molecules in Neuroscience (MMiN) was held in Gothenburg, Sweden in late spring 2016. This conference originated as a methods meeting focused on in vivo voltammetric techniques and microdialysis. Over time, however, the scope has evolved to include a number of other methods for neurochemical detection that range from single-cell fluorescence in vitro and in vivo in animal models to whole-brain imaging in humans. Overall, MMiN provides a unique forum for introducing new developments in neurochemical detection, as well as for reporting exciting neurobiological insights provided by established and novel methods...
February 15, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28161776/lncrnas-macromolecules-with-big-roles-in-neurobiology-and-neurological-diseases
#16
REVIEW
Ye Chen, Jun Zhou
Long noncoding RNAs (lncRNAs) are recently defined as thousands of RNA molecules longer than 200 nucleotides and lacking an appreciable open reading frame in mammals. Although lncRNAs lack protein-coding function, they play critical roles in the regulation of almost all the protein-coding genes in a cell at various stages including chromatin modification, transcription and post-transcriptional processing. It is thus not surprising that lncRNAs may be the crucial regulators in the normal development, physiology and pathology...
April 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28161753/lens-biology-is-a-dimension-of-neurobiology
#17
REVIEW
Peter Frederikse, Chinnaswamy Kasinathan
There is a second cell type in your body that expresses scores of the most intensively studied genes in neuroscience and exclusively shares critical interdependent modes of molecular regulation that include a network first described as responsible for the basic bifurcation of neuronal from non-neuronal gene expression in vertebrates. Neurons and lens cells are among the most ancient animal cell types, yet neurons have an exclusive status also attributed to roles underlying sensation, movement, and cognition...
February 4, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28160021/are-multitasking-abilities-impaired-in-welders-exposed-to-manganese-translating-cognitive-neuroscience-to-neurotoxicology
#18
Christoph van Thriel, Clara Quetscher, Beate Pesch, Anne Lotz, Martin Lehnert, Swaantje Casjens, Tobias Weiss, Rainer Van Gelder, Katrin Plitzke, Thomas Brüning, Christian Beste
Manganese (Mn) is an essential trace element with well characterized neurotoxic effects in high concentrations. Neurochemically, the initial neurotoxic effect of Mn is the perturbation of striatal γ-aminobutyric acid levels. Specific tasks for the assessment of cognitive functions subserved by fronto-striatal loops are available as the stop-change task (SCT) assessing control of multi-component behavior and action cascading. In a cross-sectional study, fifty male welders and 28 age-matched controls completed the SCT during a whole day examination...
February 3, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28129381/comparative-cytogenetics-between-two-important-songbird-models-the-zebra-finch-and-the-canary
#19
Michelly da Silva Dos Santos, Rafael Kretschmer, Carolina Frankl-Vilches, Antje Bakker, Manfred Gahr, Patricia C M O Brien, Malcolm A Ferguson-Smith, Edivaldo H C de Oliveira
Songbird species (order Passeriformes, suborder Oscines) are important models in various experimental fields spanning behavioural genomics to neurobiology. Although the genomes of some songbird species were sequenced recently, the chromosomal organization of these species is mostly unknown. Here we focused on the two most studied songbird species in neuroscience, the zebra finch (Taeniopygia guttata) and the canary (Serinus canaria). In order to clarify these issues and also to integrate chromosome data with their assembled genomes, we used classical and molecular cytogenetics in both zebra finch and canary to define their chromosomal homology, localization of heterochromatic blocks and distribution of rDNA clusters...
2017: PloS One
https://www.readbyqxmd.com/read/28127962/hitchhiker-s-guide-to-voltammetry-acute-and-chronic-electrodes-for-in-vivo-fast-scan-cyclic-voltammetry
#20
Nathan T Rodeberg, Stefan G Sandberg, Justin A Johnson, Paul E M Phillips, R Mark Wightman
Fast-scan cyclic voltammetry (FSCV) has been used for over 20 years to study rapid neurotransmission in awake and behaving animals. These experiments were first carried out with carbon-fiber microelectrodes (CFMs) encased in borosilicate glass, which can be inserted into the brain through micromanipulators and guide cannulas. More recently, chronically implantable CFMs constructed with small diameter fused-silica have been introduced. These electrodes can be affixed in the brain with minimal tissue response, which permits longitudinal measurements of neurotransmission in single recording locations during behavior...
February 9, 2017: ACS Chemical Neuroscience
keyword
keyword
41702
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"