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https://www.readbyqxmd.com/read/28097498/clinical-applications-of-a-ct-window-blending-algorithm-radio-relative-attenuation-dependent-image-overlay
#1
Jacob C Mandell, Bharti Khurana, Les R Folio, Hyewon Hyun, Stacy E Smith, Ruth M Dunne, Katherine P Andriole
A methodology is described using Adobe Photoshop and Adobe Extendscript to process DICOM images with a Relative Attenuation-Dependent Image Overlay (RADIO) algorithm to visualize the full dynamic range of CT in one view, without requiring a change in window and level settings. The potential clinical uses for such an algorithm are described in a pictorial overview, including applications in emergency radiology, oncologic imaging, and nuclear medicine and molecular imaging.
January 17, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28034526/reply
#2
Eric H Kim, Anup S Shetty, Kathryn J Fowler, Robert L Grubb, Gerald L Andriole
No abstract text is available yet for this article.
December 26, 2016: Urology
https://www.readbyqxmd.com/read/28024967/extent-of-baseline-prostate-atrophy-is-associated-with-lower-incidence-of-low-and-high-grade-prostate-cancer-on-repeat-biopsy
#3
Dmo Freitas, G L Andriole, R Castro-Santamaria, S J Freedland, D M Moreira
OBJECTIVES: To evaluate whether baseline prostate atrophy (PA) extent is associated with prostate cancer (PCa) incidence at 2-year repeat prostate biopsy in a clinical trial with systematic biopsies. METHODS: We performed a retrospective analysis of 3,165 men 50-75 years-old with prostate-specific antigen (PSA) between 2.5-10ng/mL and a prior negative biopsy in the placebo arm of the Reduction by Dutasteride of PCa Events (REDUCE) trial who underwent a 2-year repeat biopsy...
December 23, 2016: Urology
https://www.readbyqxmd.com/read/28004415/serum-cholesterol-and-risk-of-lower-urinary-tract-symptoms-progression-results-from-the-reduction-by-dutasteride-of-prostate-cancer-events-study
#4
Tom Feng, Lauren E Howard, Adriana C Vidal, Daniel M Moreira, Ramiro Castro-Santamaria, Gerald L Andriole, Stephen J Freedland
OBJECTIVE: To determine if cholesterol is a risk factor for the development of lower urinary tract symptoms in asymptomatic men. METHODS: A post-hoc analysis of the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) study was carried out in 2323 men with baseline International Prostate Symptom Score <8 and not taking benign prostatic hyperplasia or cholesterol medications. Cox proportion models were used to test the association between cholesterol, high-density lipoprotein, low-density lipoprotein and the cholesterol : high-density lipoprotein ratio with incident lower urinary tract symptoms, defined as first report of medical treatment, surgery or two reports of an International Prostate Symptom Score >14...
December 22, 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/27990661/association-of-obesity-related-hemodilution-of-prostate-specific-antigen-dihydrotestosterone-and-testosterone
#5
Zachary Klaassen, Lauren E Howard, Daniel M Moreira, Gerald L Andriole, Martha K Terris, Stephen J Freedland
BACKGROUND: Prostate-specific antigen (PSA) hemodilution is the leading theory for lower PSA values in obese men. However, testosterone and dihydrotestosterone (DHT), which are necessary for PSA production, are reduced in obese men. We assessed the relationship of body mass index (BMI) and PSA, taking into consideration the effect of testosterone and DHT. METHODS: Among 8,122 participants in Reduction by Dutasteride of Prostate Cancer Events (REDUCE), complete data were available for 7,275...
December 19, 2016: Prostate
https://www.readbyqxmd.com/read/27919668/magnetic-resonance-imaging-provides-added-value-to-the-prostate-cancer-prevention-trial-risk-calculator-for-patients-with-estimated-risk-of-high-grade-prostate-cancer-less-than-or-equal-to-10
#6
Eric H Kim, John K Weaver, Anup S Shetty, Joel M Vetter, Gerald L Andriole, Seth A Strope
OBJECTIVE: To determine the added value of prostate magnetic resonance imaging (MRI) to the Prostate Cancer Prevention Trial risk calculator. METHODS: Between January 2012 and December 2015, 339 patients underwent prostate MRI prior to biopsy at our institution. MRI was considered positive if there was at least 1 Prostate Imaging Reporting and Data System 4 or 5 MRI suspicious region. Logistic regression was used to develop 2 models: biopsy outcome as a function of the (1) Prostate Cancer Prevention Trial risk calculator alone and (2) combined with MRI findings...
December 2, 2016: Urology
https://www.readbyqxmd.com/read/27911486/extended-mortality-results-for-prostate-cancer-screening-in-the-plco-trial-with-median-follow-up-of-15-years
#7
Paul F Pinsky, Philip C Prorok, Kelly Yu, Barnett S Kramer, Amanda Black, John K Gohagan, E David Crawford, Robert L Grubb, Gerald L Andriole
BACKGROUND: Two large-scale prostate cancer screening trials using prostate-specific antigen (PSA) have given conflicting results in terms of the efficacy of such screening. One of those trials, the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, previously reported outcomes with 13 years of follow-up. This study presents updated findings from the PLCO trial. METHODS: The PLCO trial randomized subjects from 1993 to 2001 to an intervention or control arm...
December 1, 2016: Cancer
https://www.readbyqxmd.com/read/27845218/determination-of-the-role-of-negative-magnetic-resonance-imaging-of-the-prostate-in-clinical-practice-is-biopsy-still-necessary
#8
Robert S Wang, Eric H Kim, Joel M Vetter, Kathryn J Fowler, Anup S Shetty, Aaron J Mintz, Niraj G Badhiwala, Robert L Grubb, Gerald L Andriole
OBJECTIVE: To assess the negative predictive value (NPV) of multiparametric magnetic resonance imaging (mpMRI) for detection of prostate cancer (PCa) in routine clinical practice and to identify characteristics of patients for whom mpMRI fails to detect high-grade (Gleason score ≥7) disease. MATERIALS AND METHODS: We reviewed our prospectively maintained database of consecutive men who received prostate mpMRI at our institution, interpreted by a clinical practice of academic radiologists...
November 11, 2016: Urology
https://www.readbyqxmd.com/read/27810449/detection-of-high-grade-prostate-cancer-among-plco-participants-using-a-prespecified-four-kallikrein-marker-panel
#9
Eric H Kim, Gerald L Andriole, E David Crawford, Daniel D Sjoberg, Melissa Assel, Andrew J Vickers, Hans Lilja
PURPOSE: To assess the performance of a four-kallikrein panel, with and without microseminoprotein-beta (MSP), to predict high-grade (Gleason 7+, Gleason Grade Group 2+) prostate cancer (PCa) on biopsy in a multiethnic cohort from the Prostate, Lung, Colorectal, and Ovarian (PLCO) cancer screening trial. MATERIALS AND METHODS: Levels of free, intact, total prostate-specific antigen (PSA), human kallikrein-2, and MSP were measured blinded to outcome in cryo-preserved serum from men in the intervention arm of PLCO...
October 31, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27687750/quality-improvement-of-breast-mri-reports-with-standardized-templates-for%C3%A2-structured-reporting
#10
Dorothy A Sippo, Robyn L Birdwell, Katherine P Andriole, Sughra Raza
No abstract text is available yet for this article.
September 24, 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27494864/racial-differences-in-prostate-inflammation-results-from-the-reduce-study
#11
Adriana C Vidal, Zinan Chen, Lauren E Howard, Daniel M Moreira, Ramiro Castro-Santamaria, Gerald L Andriole, Emanuela Taioli, Jay H Fowke, Beatrice Knudsen, Charles G Drake, J Curtis Nickel, Stephen J Freedland
Prostate cancer (PC) risk differs between races, and we previously showed prostate inflammation in benign prostate tissue was linked with a lower future PC risk. However, whether prostate tissue inflammation varies by race is unknown. We analyzed baseline acute and chronic prostate inflammation by race in REDUCE, a 4-year, multicenter, placebo-controlled study where all men had a negative prostate biopsy prior to enrollment. We included 7,982 men with standardized central pathology review to determine the presence or absence of chronic or acute inflammation in baseline prostate biopsy tissue...
July 18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27453612/characteristics-and-career-intentions-of-md-mph-program-graduates-a-national-cohort-study
#12
Dorothy A Andriole, Donna B Jeffe, Robert H Tai
No abstract text is available yet for this article.
July 2016: Public Health Reports
https://www.readbyqxmd.com/read/27450264/what-is-a-medical-imaging-informaticist-and-what-does-she-do
#13
Katherine P Andriole
No abstract text is available yet for this article.
October 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27358328/eligibility-requirements-for-advanced-health-informatics-certification
#14
Cynthia S Gadd, Jeffrey J Williamson, Elaine B Steen, Katherine P Andriole, Connie Delaney, Karl Gumpper, Martin LaVenture, Doug Rosendale, Dean F Sittig, Thankam Thyvalikakath, Peggy Turner, Douglas B Fridsma
AMIA is leading the effort to strengthen the health informatics profession by creating an advanced health informatics certification (AHIC) for individuals whose informatics work directly impacts the practice of health care, public health, or personal health. The AMIA Board of Directors has endorsed a set of proposed AHIC eligibility requirements that will be presented to the future AHIC certifying entity for adoption. These requirements specifically establish who will be eligible to sit for the AHIC examination and more generally signal the depth and breadth of knowledge and experience expected from certified individuals...
July 2016: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/27346343/decreased-consumption-of-branched-chain-amino-acids-improves-metabolic-health
#15
Luigi Fontana, Nicole E Cummings, Sebastian I Arriola Apelo, Joshua C Neuman, Ildiko Kasza, Brian A Schmidt, Edda Cava, Francesco Spelta, Valeria Tosti, Faizan A Syed, Emma L Baar, Nicola Veronese, Sara E Cottrell, Rachel J Fenske, Beatrice Bertozzi, Harpreet K Brar, Terri Pietka, Arnold D Bullock, Robert S Figenshau, Gerald L Andriole, Matthew J Merrins, Caroline M Alexander, Michelle E Kimple, Dudley W Lamming
Protein-restricted (PR), high-carbohydrate diets improve metabolic health in rodents, yet the precise dietary components that are responsible for these effects have not been identified. Furthermore, the applicability of these studies to humans is unclear. Here, we demonstrate in a randomized controlled trial that a moderate PR diet also improves markers of metabolic health in humans. Intriguingly, we find that feeding mice a diet specifically reduced in branched-chain amino acids (BCAAs) is sufficient to improve glucose tolerance and body composition equivalently to a PR diet via metabolically distinct pathways...
July 12, 2016: Cell Reports
https://www.readbyqxmd.com/read/27322470/urinary-metabolomics-identifies-a-molecular-correlate-of-interstitial-cystitis-bladder-pain-syndrome-in-a-multidisciplinary-approach-to-the-study-of-chronic-pelvic-pain-mapp-research-network-cohort
#16
Kaveri S Parker, Jan R Crowley, Alisa J Stephens-Shields, Adrie van Bokhoven, M Scott Lucia, H Henry Lai, Gerald L Andriole, Thomas M Hooton, Chris Mullins, Jeffrey P Henderson
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a poorly understood syndrome affecting up to 6.5% of adult women in the U.S. The lack of broadly accepted objective laboratory markers for this condition hampers efforts to diagnose and treat this condition. To identify biochemical markers for IC/BPS, we applied mass spectrometry-based global metabolite profiling to urine specimens from a cohort of female IC/BPS subjects from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network...
May 2016: EBioMedicine
https://www.readbyqxmd.com/read/27291652/final-results-of-a-phase-i-ii-multicenter-trial-of-wst11-vascular-targeted-photodynamic-therapy-for-hemi-ablation-of-the-prostate-in-men-with-unilateral-low-risk-prostate-cancer-performed-in-the-united-states
#17
Samir S Taneja, James Bennett, Jonathan Coleman, Robert Grubb, Gerald Andriole, Robert E Reiter, Leonard Marks, Abdel-Rahmene Azzouzi, Mark Emberton
PURPOSE: Vascular targeted photodynamic therapy with WST11 (TOOKAD® Soluble) is a form of tissue ablation that may be used therapeutically for localized prostate cancer. To study dosing parameters and associated treatment effects we performed a prospective, multicenter, phase I/II trial of WST11 vascular targeted photodynamic therapy of prostate cancer. MATERIALS AND METHODS: A total of 30 men with unilateral, low volume, Gleason 3 + 3 prostate cancer were enrolled at 5 centers after local institutional review board approval...
October 2016: Journal of Urology
https://www.readbyqxmd.com/read/27286108/prostate-mri-a-national-survey-of-urologist-s-attitudes-and-perceptions
#18
Brandon J Manley, John A Brockman, Valary T Raup, Kathryn J Fowler, Gerald L Andriole
INTRODUCTION: The use of multi-parametric (MP) MRI to diagnose prostate cancer has been the subject of intense research, with many studies showing positive results. The purpose of our study is to better understand the accessibility, role, and perceived accuracy of MP-MRI in practice by surveying practicing urologists. MATERIALS AND METHODS: Surveys were sent to 7,400 practicing American Urological Association member physicians with a current email address. The survey asked demographic information and addressed access, accuracy, cost, and role of prostate MRI in clinical practice...
May 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27235913/screening-and-testing-in-multiples
#19
REVIEW
Mark I Evans, Stephanie Andriole, Shara M Evans
The choice of screening or invasive procedure in twin pregnancies is a personal choice of whether the patient wishes to take a small risk of having a baby with a serious disorder versus a small risk of having a complication because she wishes to avoid that. How to interpret such risks has profound effects on the perceived value of techniques, either leading to a decision to screening or going directly to chorionic villus sampling. There are profound issues surrounding the data and the interpretation of the data...
June 2016: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/27195318/electronic-nutritional-intake-assessment-in-patients-with-urolithiasis-a-decision-impact-analysis
#20
Avory M Heningburg, Anand Mohapatra, Aaron M Potretzke, Alyssa Park, Alethea G Paradis, Joel Vetter, Adrienne N Kuxhausen, Leslie D McIntosh, Anthony Juehne, Alana C Desai, Gerald L Andriole, Brian M Benway
PURPOSE: To evaluate a physician's impression of a urinary stone patient's dietary intake and whether it was dependent on the medium through which the nutritional data were obtained. Furthermore, we sought to determine if using an electronic food frequency questionnaire (FFQ) impacted dietary recommendations for these patients. MATERIALS AND METHODS: Seventy-six patients attended the Stone Clinic over a period of 6 weeks. Seventy-five gave consent for enrollment in our study...
May 2016: Investigative and Clinical Urology
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