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https://www.readbyqxmd.com/read/28585572/the-combination-of-histological-prostate-atrophy-and-inflammation-is-associated-with-lower-risk-of-prostate-cancer-in-biopsy-specimens
#1
D M Moreira, D M de O Freitas, J C Nickel, G L Andriole, R Castro-Santamaria, S J Freedland
BACKGROUND: To evaluate whether the presence of both prostate atrophy (PA) and chronic prostate inflammation (CPI) in the same biopsy and in the same biopsy core are associated with prostate cancer (PCa) risk and grade in repeat biopsies. METHODS: Retrospective analyses of 6132 men who were 50-75 years old undergoing 2-year repeat prostate biopsy after a negative baseline biopsy for PCa in the REduction by DUtasteride of prostate Cancer Events (REDUCE) study. PA, CPI and PCa were determined by central pathology...
June 6, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28572179/examining-summer-laboratory-research-apprenticeships-for-high-school-students-as-a-factor-in-entry-to-md-phd-programs-at-matriculation
#2
Robert H Tai, Xiaoqing Kong, Claire E Mitchell, Katherine P Dabney, Daniel M Read, Donna B Jeffe, Dorothy A Andriole, Heather D Wathington
Do summer laboratory research apprenticeships during high school have an impact on entry into MD/PhD programs? Apart from the nearly decade-long span of time between high school and matriculation into an MD/PhD program, young people have many life-shaping experiences that presumably impact their education and career trajectories. This quantitative study (n = 236,432) examines the connection between early laboratory research apprenticeship experiences at the high school level and matriculation into one of the more rigorous educational programs for scientific research training...
2017: CBE Life Sciences Education
https://www.readbyqxmd.com/read/28487295/statin-use-serum-lipids-and-prostate-inflammation-in-men-with-a-negative-prostate-biopsy-results-from-the-reduce-trial
#3
Emma H Allott, Lauren E Howard, Adriana C Vidal, Daniel M Moreira, Ramiro Castro-Santamaria, Gerald L Andriole, Stephen J Freedland
Statin use is associated with lower advanced prostate cancer risk. In addition to cholesterol lowering, statins have systemic anti-inflammatory properties. However, their effect on histologic prostate inflammation is not well understood, particularly among men at increased prostate cancer risk but with a negative prostate biopsy. We examined associations between serum lipid levels, statin use, and histologic prostate inflammation using data from 6,655 men with a negative baseline prostate biopsy in the REduction by DUtasteride of prostate Cancer Events (REDUCE) trial...
June 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28396999/dutasteride-is-associated-with-reduced-risk-of-transrectal-prostate-biopsy-associated-urinary-tract-infection-and-related-hospitalizations
#4
Daniel M Moreira, Gerald L Andriole, J Curtis Nickel, Claus G Roehrborn, Ramiro Castro-Santamaria, Stephen J Freedland
OBJECTIVES: To evaluate whether the use of dutasteride is associated with a lower risk of transrectal prostate biopsy-associated urinary tract infection (TPBA-UTI) among men in the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) study. METHODS: Retrospective analysis of 6045 men undergoing 2-year repeat prostate biopsy in REDUCE. Participants were randomized to receive dutasteride 0.5 mg or placebo daily. TPBA-UTI was defined as the presence of urinary symptoms and the prescription of antibiotics by the treating physician within 30 days after biopsy...
April 10, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28371107/using-clinically-acquired-mri-to-construct-age-specific-adc-atlases-quantifying-spatiotemporal-adc-changes-from-birth-to-6-year-old
#5
Yangming Ou, Lilla Zöllei, Kallirroi Retzepi, Victor Castro, Sara V Bates, Steve Pieper, Katherine P Andriole, Shawn N Murphy, Randy L Gollub, Patricia Ellen Grant
Diffusion imaging is critical for detecting acute brain injury. However, normal apparent diffusion coefficient (ADC) maps change rapidly in early childhood, making abnormality detection difficult. In this article, we explored clinical PACS and electronic healthcare records (EHR) to create age-specific ADC atlases for clinical radiology reference. Using the EHR and three rounds of multiexpert reviews, we found ADC maps from 201 children 0-6 years of age scanned between 2006 and 2013 who had brain MRIs with no reported abnormalities and normal clinical evaluations 2+ years later...
June 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28097498/clinical-applications-of-a-ct-window-blending-algorithm-radio-relative-attenuation-dependent-image-overlay
#6
Jacob C Mandell, Bharti Khurana, Les R Folio, Hyewon Hyun, Stacy E Smith, Ruth M Dunne, Katherine P Andriole
A methodology is described using Adobe Photoshop and Adobe Extendscript to process DICOM images with a Relative Attenuation-Dependent Image Overlay (RADIO) algorithm to visualize the full dynamic range of CT in one view, without requiring a change in window and level settings. The potential clinical uses for such an algorithm are described in a pictorial overview, including applications in emergency radiology, oncologic imaging, and nuclear medicine and molecular imaging.
June 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28034526/reply
#7
Eric H Kim, Anup S Shetty, Kathryn J Fowler, Robert L Grubb, Gerald L Andriole
No abstract text is available yet for this article.
December 26, 2016: Urology
https://www.readbyqxmd.com/read/28024967/extent-of-baseline-prostate-atrophy-is-associated-with-lower-incidence-of-low-and-high-grade-prostate-cancer-on-repeat-biopsy
#8
Daniel M Freitas, Gerald L Andriole, Ramiro Castro-Santamaria, Stephen J Freedland, Daniel M Moreira
OBJECTIVE: To evaluate whether baseline prostate atrophy (PA) extent is associated with prostate cancer (PCa) incidence at 2-year repeat prostate biopsy in a clinical trial with systematic biopsies. MATERIALS AND METHODS: We performed a retrospective analysis of 3165 men 50-75 years old with prostate-specific antigen between 2.5 and 10 ng/mL and a prior negative biopsy in the placebo arm of the Reduction by Dutasteride of PCa Events trial who underwent a 2-year repeat biopsy...
May 2017: Urology
https://www.readbyqxmd.com/read/28004415/serum-cholesterol-and-risk-of-lower-urinary-tract-symptoms-progression-results-from-the-reduction-by-dutasteride-of-prostate-cancer-events-study
#9
Tom Feng, Lauren E Howard, Adriana C Vidal, Daniel M Moreira, Ramiro Castro-Santamaria, Gerald L Andriole, Stephen J Freedland
OBJECTIVE: To determine if cholesterol is a risk factor for the development of lower urinary tract symptoms in asymptomatic men. METHODS: A post-hoc analysis of the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) study was carried out in 2323 men with baseline International Prostate Symptom Score <8 and not taking benign prostatic hyperplasia or cholesterol medications. Cox proportion models were used to test the association between cholesterol, high-density lipoprotein, low-density lipoprotein and the cholesterol : high-density lipoprotein ratio with incident lower urinary tract symptoms, defined as first report of medical treatment, surgery or two reports of an International Prostate Symptom Score >14...
December 22, 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/27990661/association-of-obesity-related-hemodilution-of-prostate-specific-antigen-dihydrotestosterone-and-testosterone
#10
Zachary Klaassen, Lauren E Howard, Daniel M Moreira, Gerald L Andriole, Martha K Terris, Stephen J Freedland
BACKGROUND: Prostate-specific antigen (PSA) hemodilution is the leading theory for lower PSA values in obese men. However, testosterone and dihydrotestosterone (DHT), which are necessary for PSA production, are reduced in obese men. We assessed the relationship of body mass index (BMI) and PSA, taking into consideration the effect of testosterone and DHT. METHODS: Among 8,122 participants in Reduction by Dutasteride of Prostate Cancer Events (REDUCE), complete data were available for 7,275...
December 19, 2016: Prostate
https://www.readbyqxmd.com/read/27919668/magnetic-resonance-imaging-provides-added-value-to-the-prostate-cancer-prevention-trial-risk-calculator-for-patients-with-estimated-risk-of-high-grade-prostate-cancer-less-than-or-equal-to-10
#11
Eric H Kim, John K Weaver, Anup S Shetty, Joel M Vetter, Gerald L Andriole, Seth A Strope
OBJECTIVE: To determine the added value of prostate magnetic resonance imaging (MRI) to the Prostate Cancer Prevention Trial risk calculator. METHODS: Between January 2012 and December 2015, 339 patients underwent prostate MRI prior to biopsy at our institution. MRI was considered positive if there was at least 1 Prostate Imaging Reporting and Data System 4 or 5 MRI suspicious region. Logistic regression was used to develop 2 models: biopsy outcome as a function of the (1) Prostate Cancer Prevention Trial risk calculator alone and (2) combined with MRI findings...
December 2, 2016: Urology
https://www.readbyqxmd.com/read/27911486/extended-mortality-results-for-prostate-cancer-screening-in-the-plco-trial-with-median-follow-up-of-15-years
#12
RANDOMIZED CONTROLLED TRIAL
Paul F Pinsky, Philip C Prorok, Kelly Yu, Barnett S Kramer, Amanda Black, John K Gohagan, E David Crawford, Robert L Grubb, Gerald L Andriole
BACKGROUND: Two large-scale prostate cancer screening trials using prostate-specific antigen (PSA) have given conflicting results in terms of the efficacy of such screening. One of those trials, the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, previously reported outcomes with 13 years of follow-up. This study presents updated findings from the PLCO trial. METHODS: The PLCO trial randomized subjects from 1993 to 2001 to an intervention or control arm...
February 15, 2017: Cancer
https://www.readbyqxmd.com/read/27845218/determination-of-the-role-of-negative-magnetic-resonance-imaging-of-the-prostate-in-clinical-practice-is-biopsy-still-necessary
#13
Robert S Wang, Eric H Kim, Joel M Vetter, Kathryn J Fowler, Anup S Shetty, Aaron J Mintz, Niraj G Badhiwala, Robert L Grubb, Gerald L Andriole
OBJECTIVE: To assess the negative predictive value (NPV) of multiparametric magnetic resonance imaging (mpMRI) for detection of prostate cancer (PCa) in routine clinical practice and to identify characteristics of patients for whom mpMRI fails to detect high-grade (Gleason score ≥7) disease. MATERIALS AND METHODS: We reviewed our prospectively maintained database of consecutive men who received prostate mpMRI at our institution, interpreted by a clinical practice of academic radiologists...
November 11, 2016: Urology
https://www.readbyqxmd.com/read/27810449/detection-of-high-grade-prostate-cancer-among-plco-participants-using-a-prespecified-4-kallikrein-marker-panel
#14
Eric H Kim, Gerald L Andriole, E David Crawford, Daniel D Sjoberg, Melissa Assel, Andrew J Vickers, Hans Lilja
PURPOSE: We assessed the performance of a 4-kallikrein panel with and without microseminoprotein-β to predict high grade (Gleason 7+/Gleason Grade Group 2+) prostate cancer on biopsy in a multiethnic cohort from PLCO (Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial). MATERIALS AND METHODS: Levels of free, intact, total prostate specific antigen, human kallikrein-2 and microseminoprotein-β were measured while blinded to outcomes in cryopreserved serum from men in the intervention arm of PLCO...
April 2017: Journal of Urology
https://www.readbyqxmd.com/read/27687750/quality-improvement-of-breast-mri-reports-with-standardized-templates-for%C3%A2-structured-reporting
#15
Dorothy A Sippo, Robyn L Birdwell, Katherine P Andriole, Sughra Raza
No abstract text is available yet for this article.
September 24, 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27494864/racial-differences-in-prostate-inflammation-results-from-the-reduce-study
#16
Adriana C Vidal, Zinan Chen, Lauren E Howard, Daniel M Moreira, Ramiro Castro-Santamaria, Gerald L Andriole, Emanuela Taioli, Jay H Fowke, Beatrice Knudsen, Charles G Drake, J Curtis Nickel, Stephen J Freedland
Prostate cancer (PC) risk differs between races, and we previously showed prostate inflammation in benign prostate tissue was linked with a lower future PC risk. However, whether prostate tissue inflammation varies by race is unknown. We analyzed baseline acute and chronic prostate inflammation by race in REDUCE, a 4-year, multicenter, placebo-controlled study where all men had a negative prostate biopsy prior to enrollment. We included 7,982 men with standardized central pathology review to determine the presence or absence of chronic or acute inflammation in baseline prostate biopsy tissue...
July 18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27453612/characteristics-and-career-intentions-of-md-mph-program-graduates-a-national-cohort-study
#17
Dorothy A Andriole, Donna B Jeffe, Robert H Tai
No abstract text is available yet for this article.
July 2016: Public Health Reports
https://www.readbyqxmd.com/read/27450264/what-is-a-medical-imaging-informaticist-and-what-does-she-do
#18
Katherine P Andriole
No abstract text is available yet for this article.
October 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27358328/eligibility-requirements-for-advanced-health-informatics-certification
#19
Cynthia S Gadd, Jeffrey J Williamson, Elaine B Steen, Katherine P Andriole, Connie Delaney, Karl Gumpper, Martin LaVenture, Doug Rosendale, Dean F Sittig, Thankam Thyvalikakath, Peggy Turner, Douglas B Fridsma
AMIA is leading the effort to strengthen the health informatics profession by creating an advanced health informatics certification (AHIC) for individuals whose informatics work directly impacts the practice of health care, public health, or personal health. The AMIA Board of Directors has endorsed a set of proposed AHIC eligibility requirements that will be presented to the future AHIC certifying entity for adoption. These requirements specifically establish who will be eligible to sit for the AHIC examination and more generally signal the depth and breadth of knowledge and experience expected from certified individuals...
July 2016: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/27346343/decreased-consumption-of-branched-chain-amino-acids-improves-metabolic-health
#20
Luigi Fontana, Nicole E Cummings, Sebastian I Arriola Apelo, Joshua C Neuman, Ildiko Kasza, Brian A Schmidt, Edda Cava, Francesco Spelta, Valeria Tosti, Faizan A Syed, Emma L Baar, Nicola Veronese, Sara E Cottrell, Rachel J Fenske, Beatrice Bertozzi, Harpreet K Brar, Terri Pietka, Arnold D Bullock, Robert S Figenshau, Gerald L Andriole, Matthew J Merrins, Caroline M Alexander, Michelle E Kimple, Dudley W Lamming
Protein-restricted (PR), high-carbohydrate diets improve metabolic health in rodents, yet the precise dietary components that are responsible for these effects have not been identified. Furthermore, the applicability of these studies to humans is unclear. Here, we demonstrate in a randomized controlled trial that a moderate PR diet also improves markers of metabolic health in humans. Intriguingly, we find that feeding mice a diet specifically reduced in branched-chain amino acids (BCAAs) is sufficient to improve glucose tolerance and body composition equivalently to a PR diet via metabolically distinct pathways...
July 12, 2016: Cell Reports
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