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https://www.readbyqxmd.com/read/29069714/racial-differences-in-prostate-inflammation-results-from-the-reduce-study
#1
Adriana C Vidal, Zinan Chen, Lauren E Howard, Daniel M Moreira, Ramiro Castro-Santamaria, Gerald L Andriole, Emanuela Taioli, Jay H Fowke, Beatrice Knudsen, Charles G Drake, J Curtis Nickel, Stephen J Freedland
Prostate cancer (PC) risk differs between races, and we previously showed prostate inflammation in benign prostate tissue was linked with a lower future PC risk. However, whether prostate tissue inflammation varies by race is unknown. We analyzed baseline acute and chronic prostate inflammation by race in REDUCE, a 4-year, multicenter, placebo-controlled study where all men had a negative prostate biopsy prior to enrollment. We included 7,982 men with standardized central pathology review to determine the presence or absence of chronic or acute inflammation in baseline prostate biopsy tissue...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28954846/prevalence-and-predictors-of-us-medical-graduates-federal-f32-mentored-k-and-r01-awards-a-national-cohort-study
#2
Donna B Jeffe, Dorothy A Andriole
The size and diversity of the physician-scientist workforce are issues of national concern. In this retrospective, national cohort study of US medical school matriculants who graduated in 1997-2004, we describe the prevalence and predictors of federal F32, mentored-K, and R01 awards among physicians. In multivariable logistic regression models, we identified demographic, educational, and professional development variables independently associated with each award through August 2014, reporting adjusted odds ratios and 95% confidence intervals (AOR (95% CI))...
September 27, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28952986/in-reply-to-andriole-and-jeffe
#3
Alison Riese, Brian Alverson, Randal M Rockney
No abstract text is available yet for this article.
October 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28952985/a-closer-look-at-clinical-performance-evaluations
#4
Dorothy A Andriole, Donna B Jeffe
No abstract text is available yet for this article.
October 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28870861/sleep-problems-are-associated-with-development-and-progression-of-lower-urinary-tract-symptoms-results-from-reduce
#5
Brandee L Branche, Lauren E Howard, Daniel M Moreira, Claus Roehrborn, Ramiro Castro-Santamaria, Gerald L Andriole, Martin L Hopp, Stephen J Freedland
PURPOSE: Although lower urinary tract symptoms and sleep problems often develop together, to our knowledge it is unknown whether sleep disturbances are linked to lower urinary tract symptoms development and progression. As measured by the 6-item MOS-Sleep (Medical Outcomes Study Sleep Scale) survey we examined the relationship of sleep problems to the development and progression of lower urinary tract symptoms in the REDUCE (Reduction by Dutasteride of Prostate Cancer Events) study. MATERIALS AND METHODS: REDUCE was a randomized trial testing prostate cancer chemoprevention with dutasteride in men with prostate specific antigen 2...
September 1, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28869989/reconciling-the-effects-of-screening-on-prostate-cancer-mortality-in-the-erspc-and-plco-trials
#6
Alex Tsodikov, Roman Gulati, Eveline A M Heijnsdijk, Paul F Pinsky, Sue M Moss, Sheng Qiu, Tiago M de Carvalho, Jonas Hugosson, Christine D Berg, Anssi Auvinen, Gerald L Andriole, Monique J Roobol, E David Crawford, Vera Nelen, Maciej Kwiatkowski, Marco Zappa, Marcos Luján, Arnauld Villers, Eric J Feuer, Harry J de Koning, Angela B Mariotto, Ruth Etzioni
Background: The ERSPC (European Randomized Study of Screening for Prostate Cancer) found that screening reduced prostate cancer mortality, but the PLCO (Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial) found no reduction. Objective: To evaluate whether effects of screening on prostate cancer mortality relative to no screening differed between the ERSPC and PLCO. Design: Cox regression of prostate cancer death in each trial group, adjusted for age and trial...
October 3, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28767497/mediators-of-racial-ethnic-disparities-in-mentored-k-award-receipt-among-u-s-medical-school-graduates
#7
Dorothy A Andriole, Yan Yan, Donna B Jeffe
PURPOSE: Mentored K (K01/K08/K23) career development awards are positively associated with physicians' success as independent investigators; however, individuals in some racial/ethnic groups are less likely to receive this federal funding. The authors sought to identify variables that explain (mediate) the association between race/ethnicity and mentored K award receipt among U.S. Liaison Committee for Medical Education-accredited medical school graduates who planned research-related careers...
October 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28753804/variability-in-outcomes-for-patients-with-intermediate-risk-prostate-cancer-gleason-score-7-international-society-of-urological-pathology-gleason-group-2-3-and-implications-for-risk-stratification-a-systematic-review
#8
REVIEW
Christopher J Kane, Scott E Eggener, Alan W Shindel, Gerald L Andriole
CONTEXT: Optimal management for patients with intermediate-risk (IR) prostate cancer (PCa) remains controversial. Clinical metrics provide guidance on appropriate management options. OBJECTIVE: To report estimates for clinically relevant outcomes in men with IR PCa based on clinical and pathological features. EVIDENCE ACQUISITION: PubMed and programs from key 2015 uro-oncology congresses were searched using the terms "intermediate", "Gleason 3 + 4", "Gleason 4 + 3", "active surveillance", "treatment", "adverse pathology", AND "prostate cancer...
March 11, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28700844/follow-up-of-prostatectomy-versus-observation-for-early-prostate-cancer
#9
RANDOMIZED CONTROLLED TRIAL
Timothy J Wilt, Karen M Jones, Michael J Barry, Gerald L Andriole, Daniel Culkin, Thomas Wheeler, William J Aronson, Michael K Brawer
BACKGROUND: We previously found no significant differences in mortality between men who underwent surgery for localized prostate cancer and those who were treated with observation only. Uncertainty persists regarding nonfatal health outcomes and long-term mortality. METHODS: From November 1994 through January 2002, we randomly assigned 731 men with localized prostate cancer to radical prostatectomy or observation. We extended follow-up through August 2014 for our primary outcome, all-cause mortality, and the main secondary outcome, prostate-cancer mortality...
July 13, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28692006/brain-signature-and-functional-impact-of-centralized-pain-a-multidisciplinary-approach-to-the-study-of-chronic-pelvic-pain-mapp-network-study
#10
Jason J Kutch, Eric Ichesco, Johnson P Hampson, Jennifer S Labus, Melissa A Farmer, Katherine T Martucci, Timothy J Ness, Georg Deutsch, A Vania Apkarian, Sean C Mackey, David J Klumpp, Anthony J Schaeffer, Larissa V Rodriguez, Karl J Kreder, Dedra Buchwald, Gerald L Andriole, H Henry Lai, Chris Mullins, John W Kusek, J Richard Landis, Emeran A Mayer, J Quentin Clemens, Daniel J Clauw, Richard E Harris
Chronic pain is often measured with a severity score that overlooks its spatial distribution across the body. This widespread pain is believed to be a marker of centralization, a central nervous system process that decouples pain perception from nociceptive input. Here, we investigated whether centralization is manifested at the level of the brain using data from 1079 participants in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network (MAPP) study. Participants with a clinical diagnosis of urological chronic pelvic pain syndrome (UCPPS) were compared to pain-free controls and patients with fibromyalgia, the prototypical centralized pain disorder...
June 30, 2017: Pain
https://www.readbyqxmd.com/read/28585572/the-combination-of-histological-prostate-atrophy-and-inflammation-is-associated-with-lower-risk-of-prostate-cancer-in-biopsy-specimens
#11
D M Moreira, D M de O Freitas, J C Nickel, G L Andriole, R Castro-Santamaria, S J Freedland
BACKGROUND: To evaluate whether the presence of both prostate atrophy (PA) and chronic prostate inflammation (CPI) in the same biopsy and in the same biopsy core are associated with prostate cancer (PCa) risk and grade in repeat biopsies. METHODS: Retrospective analyses of 6132 men who were 50-75 years old undergoing 2-year repeat prostate biopsy after a negative baseline biopsy for PCa in the REduction by DUtasteride of prostate Cancer Events (REDUCE) study. PA, CPI and PCa were determined by central pathology...
December 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28572179/examining-summer-laboratory-research-apprenticeships-for-high-school-students-as-a-factor-in-entry-to-md-phd-programs-at-matriculation
#12
Robert H Tai, Xiaoqing Kong, Claire E Mitchell, Katherine P Dabney, Daniel M Read, Donna B Jeffe, Dorothy A Andriole, Heather D Wathington
Do summer laboratory research apprenticeships during high school have an impact on entry into MD/PhD programs? Apart from the nearly decade-long span of time between high school and matriculation into an MD/PhD program, young people have many life-shaping experiences that presumably impact their education and career trajectories. This quantitative study (n = 236,432) examines the connection between early laboratory research apprenticeship experiences at the high school level and matriculation into one of the more rigorous educational programs for scientific research training...
2017: CBE Life Sciences Education
https://www.readbyqxmd.com/read/28487295/statin-use-serum-lipids-and-prostate-inflammation-in-men-with-a-negative-prostate-biopsy-results-from-the-reduce-trial
#13
Emma H Allott, Lauren E Howard, Adriana C Vidal, Daniel M Moreira, Ramiro Castro-Santamaria, Gerald L Andriole, Stephen J Freedland
Statin use is associated with lower advanced prostate cancer risk. In addition to cholesterol lowering, statins have systemic anti-inflammatory properties. However, their effect on histologic prostate inflammation is not well understood, particularly among men at increased prostate cancer risk but with a negative prostate biopsy. We examined associations between serum lipid levels, statin use, and histologic prostate inflammation using data from 6,655 men with a negative baseline prostate biopsy in the REduction by DUtasteride of prostate Cancer Events (REDUCE) trial...
June 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28396999/dutasteride-is-associated-with-reduced-risk-of-transrectal-prostate-biopsy-associated-urinary-tract-infection-and-related-hospitalizations
#14
Daniel M Moreira, Gerald L Andriole, J Curtis Nickel, Claus G Roehrborn, Ramiro Castro-Santamaria, Stephen J Freedland
OBJECTIVES: To evaluate whether the use of dutasteride is associated with a lower risk of transrectal prostate biopsy-associated urinary tract infection (TPBA-UTI) among men in the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) study. METHODS: Retrospective analysis of 6045 men undergoing 2-year repeat prostate biopsy in REDUCE. Participants were randomized to receive dutasteride 0.5 mg or placebo daily. TPBA-UTI was defined as the presence of urinary symptoms and the prescription of antibiotics by the treating physician within 30 days after biopsy...
October 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28371107/using-clinically-acquired-mri-to-construct-age-specific-adc-atlases-quantifying-spatiotemporal-adc-changes-from-birth-to-6-year-old
#15
Yangming Ou, Lilla Zöllei, Kallirroi Retzepi, Victor Castro, Sara V Bates, Steve Pieper, Katherine P Andriole, Shawn N Murphy, Randy L Gollub, Patricia Ellen Grant
Diffusion imaging is critical for detecting acute brain injury. However, normal apparent diffusion coefficient (ADC) maps change rapidly in early childhood, making abnormality detection difficult. In this article, we explored clinical PACS and electronic healthcare records (EHR) to create age-specific ADC atlases for clinical radiology reference. Using the EHR and three rounds of multiexpert reviews, we found ADC maps from 201 children 0-6 years of age scanned between 2006 and 2013 who had brain MRIs with no reported abnormalities and normal clinical evaluations 2+ years later...
June 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28097498/clinical-applications-of-a-ct-window-blending-algorithm-radio-relative-attenuation-dependent-image-overlay
#16
Jacob C Mandell, Bharti Khurana, Les R Folio, Hyewon Hyun, Stacy E Smith, Ruth M Dunne, Katherine P Andriole
A methodology is described using Adobe Photoshop and Adobe Extendscript to process DICOM images with a Relative Attenuation-Dependent Image Overlay (RADIO) algorithm to visualize the full dynamic range of CT in one view, without requiring a change in window and level settings. The potential clinical uses for such an algorithm are described in a pictorial overview, including applications in emergency radiology, oncologic imaging, and nuclear medicine and molecular imaging.
June 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28034526/reply
#17
Eric H Kim, Anup S Shetty, Kathryn J Fowler, Robert L Grubb, Gerald L Andriole
No abstract text is available yet for this article.
December 26, 2016: Urology
https://www.readbyqxmd.com/read/28024967/extent-of-baseline-prostate-atrophy-is-associated-with-lower-incidence-of-low-and-high-grade-prostate-cancer-on-repeat-biopsy
#18
Daniel M Freitas, Gerald L Andriole, Ramiro Castro-Santamaria, Stephen J Freedland, Daniel M Moreira
OBJECTIVE: To evaluate whether baseline prostate atrophy (PA) extent is associated with prostate cancer (PCa) incidence at 2-year repeat prostate biopsy in a clinical trial with systematic biopsies. MATERIALS AND METHODS: We performed a retrospective analysis of 3165 men 50-75 years old with prostate-specific antigen between 2.5 and 10 ng/mL and a prior negative biopsy in the placebo arm of the Reduction by Dutasteride of PCa Events trial who underwent a 2-year repeat biopsy...
May 2017: Urology
https://www.readbyqxmd.com/read/28004415/serum-cholesterol-and-risk-of-lower-urinary-tract-symptoms-progression-results-from-the-reduction-by-dutasteride-of-prostate-cancer-events-study
#19
Tom Feng, Lauren E Howard, Adriana C Vidal, Daniel M Moreira, Ramiro Castro-Santamaria, Gerald L Andriole, Stephen J Freedland
OBJECTIVE: To determine if cholesterol is a risk factor for the development of lower urinary tract symptoms in asymptomatic men. METHODS: A post-hoc analysis of the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) study was carried out in 2323 men with baseline International Prostate Symptom Score <8 and not taking benign prostatic hyperplasia or cholesterol medications. Cox proportion models were used to test the association between cholesterol, high-density lipoprotein, low-density lipoprotein and the cholesterol : high-density lipoprotein ratio with incident lower urinary tract symptoms, defined as first report of medical treatment, surgery or two reports of an International Prostate Symptom Score >14...
December 22, 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/27990661/association-of-obesity-related-hemodilution-of-prostate-specific-antigen-dihydrotestosterone-and-testosterone
#20
RANDOMIZED CONTROLLED TRIAL
Zachary Klaassen, Lauren E Howard, Daniel M Moreira, Gerald L Andriole, Martha K Terris, Stephen J Freedland
BACKGROUND: Prostate-specific antigen (PSA) hemodilution is the leading theory for lower PSA values in obese men. However, testosterone and dihydrotestosterone (DHT), which are necessary for PSA production, are reduced in obese men. We assessed the relationship of body mass index (BMI) and PSA, taking into consideration the effect of testosterone and DHT. METHODS: Among 8,122 participants in Reduction by Dutasteride of Prostate Cancer Events (REDUCE), complete data were available for 7,275...
April 2017: Prostate
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