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https://www.readbyqxmd.com/read/29228152/effectiveness-of-nutritional-interventions-addressed-to-elderly-persons-umbrella-systematic-review-with-meta-analysis
#1
Andrea Poscia, Sonja Milovanovic, Daniele Ignazio La Milia, Mariusz Duplaga, Marcin Grysztar, Francesco Landi, Umberto Moscato, Nicola Magnavita, Agnese Collamati, Walter Ricciardi
Background: The number of Europeans aged over 65 will double between 2010 and 2060, reaching 30% of the European population. Nutrition is emerging as a key element of healthy life since both obesity and malnutrition are established risk factors for morbidity and disability. The aim of this umbrella review (UR) is to summarize the findings of all current systematic reviews (SRs) and meta-analyzes (MAs) on the effectiveness of nutritional intervention designed to promote healthy aging in older individuals...
December 8, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29227157/systematic-review-of-the-diagnostic-accuracy-of-the-non-english-versions-of-addenbrooke-s-cognitive-examination%C3%A2-%C3%A2-revised-and-iii
#2
Noor Habib, Joshua Stott
OBJECTIVE: This systematic review aims to review the evidence for the diagnostic accuracy of the non-English updated versions of Addenbrooke's Cognitive Examination (ACE) - the ACE-Revised (ACE-R) and the ACE-III - in the diagnosis of dementia. METHODS: A systematic search resulted in 16 eligible studies evaluating the diagnostic accuracy of ACE-R and ACE-III in ten different languages. Most studies were assessed as of medium to low quality using Standards for Reporting of Diagnostic Accuracy (STARD) guidance...
December 11, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/29226326/retreg1-fam134b-a-new-player-in-human-diseases-15-years-after-the-discovery-in-cancer
#3
REVIEW
Farhadul Islam, Vinod Gopalan, Alfred King-Yin Lam
FAM134B (family with sequence similarity 134, member B) / RETREG1 and its functional roles are relatively new in human diseases. This review aimed to summarize various functions of FAM134B since our first discovery of the gene in 2001. The protein encoded by FAM134B is a reticulophagy receptor that regulates turnover of the endoplasmic reticulum (ER) by selective phagocytosis. Absence or non-functional expression of FAM134B protein impairs ER-turnover and thereby is involved in the pathogenesis of some human diseases...
December 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29223191/iterating-a-framework-for-the-prevention-of-caregiver-depression-in-dementia-a-multi-method-approach
#4
Jiangbo Ying, Philip Yap, Mihir Gandhi, Tau Ming Liew
BACKGROUND: Dementia caregiving is often stressful and depression in family caregivers is not uncommon. As caregiver depression can have significant effects, there is a need for preventive efforts which are consistent with the extensive literature. We sought to consolidate the wide range of evidence (using a multi-method approach) into a simple framework that can guide the prevention of caregiver depression. METHODS: Using multiple logistic regression, we derived the predictors of caregiver depression from an empirical dataset containing key information and depression scores (based on the Center-for-Epidemiological-Studies-Depression-Scale) of 394 family caregivers...
December 10, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29222909/an-emerging-role-of-astrocytes-in-vascular-contributions-to-cognitive-impairment-and-dementia-vcid
#5
REVIEW
Brittani R Price, Christopher M Norris, Pradoldej Sompol, Donna M Wilcock
Vascular contributions to cognitive impairment and dementia (VCID) is understood to be the second most common cause of dementia after Alzheimer's disease (AD), and is also a frequent co-morbidity with AD. While VCID is widely acknowledged as a key contributor to dementia, the mechanistic underpinnings of VCID remain poorly understood. In this review, we address the potential role of astrocytes in the pathophysiology of VCID. The vast majority of the blood vessels in the brain are surrounded by astrocytic end-feet...
December 9, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29222544/association-of-age-related-hearing-loss-with-cognitive-function-cognitive-impairment-and-dementia-a-systematic-review-and-meta-analysis
#6
David G Loughrey, Michelle E Kelly, George A Kelley, Sabina Brennan, Brian A Lawlor
Importance: Epidemiologic research on the possible link between age-related hearing loss (ARHL) and cognitive decline and dementia has produced inconsistent results. Clarifying this association is of interest because ARHL may be a risk factor for outcomes of clinical dementia. Objectives: To examine and estimate the association between ARHL and cognitive function, cognitive impairment, and dementia through a systematic review and meta-analysis. Data Sources and Study Selection: A search of PubMed, the Cochrane Library, EMBASE, and SCOPUS from inception to April 15, 2016, with cross-referencing of retrieved studies and personal files for potentially eligible studies was performed...
December 7, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29221697/prevalence-of-mental-health-disorders-in-elderly-u-s-military-veterans-a-meta-analysis-and-systematic-review
#7
Victoria Williamson, Sharon A M Stevelink, Karla Greenberg, Neil Greenberg
OBJECTIVE: Older veterans may be vulnerable to mental health problems. Meta-analytic and systematic review methods sought to determine the prevalence rate of mental health disorders in older military veterans (≥65 years). METHODS: Eleven studies were eligible, and meta-analyses of veteran depression, substance abuse, post-traumatic stress disorder (PTSD), anxiety, dementia, bipolar disorder, and schizophrenia were conducted. RESULTS: Although conducted exclusively with U...
November 8, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29220386/does-cognitive-impairment-impact-adherence-a-systematic-review-and-meta-analysis-of-the-association-between-cognitive-impairment-and-medication-non-adherence-in-stroke
#8
Daniela Rohde, Niamh A Merriman, Frank Doyle, Kathleen Bennett, David Williams, Anne Hickey
BACKGROUND: While medication adherence is essential for the secondary prevention of stroke, it is often sub-optimal, and can be compromised by cognitive impairment. This study aimed to systematically review and meta-analyse the association between cognitive impairment and medication non-adherence in stroke. METHODS: A systematic literature search of longitudinal and cross-sectional studies of adults with any stroke type, which reported on the association between any measure of non-adherence and cognitive impairment, was carried out according to PRISMA guidelines...
2017: PloS One
https://www.readbyqxmd.com/read/29220126/can-the-retina-be-used-to-diagnose-and-plot-the-progression-of-alzheimer-s-disease
#9
REVIEW
Deepti Mahajan, Marcela Votruba
Alzheimer's disease (AD) is a neurodegenerative disease and the most common cause of senile dementia. It impairs the quality of life of a person and their family, posing a serious economic and social threat in developed countries. The fact that the diagnosis can only be definitively made post-mortem, or when the disease is fairly advanced, presents a serious problem if novel therapeutic interventions are to be devised and used early in the course of the disease. There is therefore a pressing need for more sensitive and specific diagnostic tests with which we can detect AD in the preclinical stage...
December 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29217728/acupuncture-for-patients-with-vascular-dementia-a-systematic-review-protocol
#10
Yang Ye, Ling-Yong Xiao, Yi-Hua Liu, Jing-Wen Yang, Chao-Qun Yan, Xue-Rui Wang, Guang-Xia Shi, Cun-Zhi Liu
INTRODUCTION: This systematic review protocol aims to provide the methods used to evaluate the effectiveness and safety of acupuncture therapy for treating vascular dementia. METHODS AND ANALYSIS: The following eight databases will be searched from inception to July 2017: Cochrane Central Register of Controlled Trials, PubMed, MEDLINE, EMBASE, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, VIP Database and Wanfang Database. All randomised controlled trials in English or Chinese related to acupuncture for vascular dementia will be included...
December 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/29216836/key-stakeholders-experiences-of-respite-services-for-people-with-dementia-and-their-perspectives-on-respite-service-development-a-qualitative-systematic-review
#11
Emma O' Shea, Suzanne Timmons, Eamon O' Shea, Siobhan Fox, Kate Irving
BACKGROUND: Respite services provide a break in the caregiving relationship for people with dementia and their carers, however they are often under-used and service acceptability can be low. This study aims to understand key stakeholders' experiences of respite services for people with dementia, with a view to informing respite service development. METHODS: A systematic search was conducted of the Pubmed/MedLine, Embase, Cinahl, PsychInfo, Scopus, Web of Science, and Cochrane databases (1980-2016, English) with fixed search terms relating to 'respite' and 'dementia', following PRISMA guidelines...
December 7, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29216743/a-systematic-scoping-review-and-synthesis-of-dementia-and-communication-theory
#12
Liam Ennis, Warren Mansell, Sara Tai, Phil McEvoy
Aim This review considers the theoretical literature concerning communication between a person with dementia and a person without dementia. Methods Theoretical accounts of communication between a person with dementia and a person without dementia were identified through database searches, hand searching of reference lists and contacting experts in the topic area. Results Twenty-one articles were included in the final review, yielding 18 different theoretical accounts of communication in the context of dementia...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/29216341/use-and-importance-of-nonhuman-primates-in-metabolic-disease-research-current-state-of-the-field
#13
Peter J Havel, Paul Kievit, Anthony G Comuzzie, Andrew A Bremer
Obesity and its multiple metabolic sequelae, including type 2 diabetes, cardiovascular disease, and fatty liver disease, are becoming increasingly widespread in both the developed and developing world. There is an urgent need to identify new approaches for the prevention and treatment of these costly and prevalent metabolic conditions. Accomplishing this will require the use of appropriate animal models for preclinical and translational investigations in metabolic disease research. Although studies in rodent models are often useful for target/pathway identification and testing hypotheses, there are important differences in metabolic physiology between rodents and primates, and experimental findings in rodent models have often failed to be successfully translated into new, clinically useful therapeutic modalities in humans...
December 5, 2017: ILAR Journal
https://www.readbyqxmd.com/read/29216339/exercise-training-for-preventing-dementia-mild-cognitive-impairment-and-clinically-meaningful-cognitive-decline-a-systematic-review-and-meta-analysis
#14
Philipe de Souto Barreto, Laurent Demougeot, Bruno Vellas, Yves Rolland
BACKGROUND: To assess the effects of long-term exercise on the onset of dementia, mild cognitive impairment (MCI), and other clinically meaningful cognitive decline in the elderly. METHODS: Systematic review with preplanned meta-analysis. Electronic searches were performed between November 2016 and May 2017. RCTs examining the effects of long-term exercise (intervention length 12 months or longer) on the onset of dementia, MCI, or clinically meaningful cognitive decline in older adults without dementia at baseline were eligible...
December 5, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29213519/language-and-communication-non-pharmacological-interventions-in-patients-with-alzheimer-s-disease-a-systematic-review-communication-intervention-in-alzheimer
#15
Aline Nunes da Cruz Morello, Tatiane Machado Lima, Lenisa Brandão
Alzheimer's disease considerably compromises communication skills. Language changes become more prominent as the disease progresses. Deterioration of language and cognition reduces the ability of holding conversations, which has a negative impact on social interaction. OBJECTIVE: To conduct a systematic review of the literature for articles reporting interventions focused on the language and communication of people with Alzheimer's disease (AD) without use of medication. METHODS: We performed a search using the keywords Alzheimer's disease, language, communication, cognition, cognitive intervention, rehabilitation and therapy, and their corresponding Portuguese and Spanish terms, on the SciELO, LILACS, PubMed and PsychINFO databases...
July 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29213508/cross-cultural-adaptation-of-the-australian-national-university-alzheimer-s-disease-risk-index-for-the-brazilian-population
#16
Marcus Kiiti Borges, Alessandro Ferrari Jacinto, Vanessa de Albuquerque Citero
Alzheimer's disease (AD) represents a major public health problem and it is therefore crucial that modifiable risk factors be known prior to onset of dementia in late-life. The "Australian National University - Alzheimer's Disease Risk Index" (ANU-ADRI) is one of the potential tools for primary prevention of the disease. Objective: The aim of this study was to devise an adapted version of the ANU-ADRI for use in Brazil. Methods: The instrument was translated from its original language of English into Portuguese and then back-translated into English by bilingual translators...
April 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29213488/scoring-systems-for-the-clock-drawing-test-a-historical-review
#17
REVIEW
Bárbara Spenciere, Heloisa Alves, Helenice Charchat-Fichman
The Clock Drawing Test (CDT) is a simple neuropsychological screening instrument that is well accepted by patients and has solid psychometric properties. Several different CDT scoring methods have been developed, but no consensus has been reached regarding which scoring method is the most accurate. This article reviews the literature on these scoring systems and the changes they have undergone over the years. Historically, different types of scoring systems emerged. Initially, the focus was on screening for dementia, and the methods were both quantitative and semi-quantitative...
January 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29210934/a-scoping-review-of-physical-performance-outcome-measures-used-in-exercise-interventions-for-older-adults-with-alzheimer-disease-and-related-dementias
#18
Ellen L McGough, Shih-Yin Lin, Basia Belza, Katie M Becofsky, Dina L Jones, Minhui Liu, Sara Wilcox, Rebecca G Logsdon
BACKGROUND AND PURPOSE: There is growing evidence that exercise interventions can mitigate functional decline and reduce fall risk in older adults with Alzheimer disease and related dementias (ADRD). Although physical performance outcome measures have been successfully used in older adults without cognitive impairment, additional research is needed regarding their use with individuals who have ADRD, and who may have difficulty following instructions regarding performance of these measures...
November 28, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29210074/white-matter-degeneration-in-vascular-and-other-ageing-related-dementias
#19
REVIEW
Yoshika Hase, Karen Horsburgh, Masafumi Ihara, Raj N Kalaria
Advances in neuroimaging have enabled greater understanding of the progression of cerebral degenerative processes associated with ageing-related dementias. Leukoaraiosis or rarefied white matter (WM) originally described on computed tomography is one of the most prominent changes which occurs in older age. White matter hyperintensities (WMH) evident on magnetic resonance imaging have become commonplace to describe WM changes in relation to cognitive dysfunction, types of stroke injury, cerebral small vessel disease and neurodegenerative disorders including Alzheimer's disease...
December 6, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29209402/analgesics-in-the-management-of-behavioral-and-psychological-symptoms-of-dementia-a-perspective-review
#20
REVIEW
Rajesh R Tampi, Corey Hassell, Pallavi Joshi, Deena J Tampi
The objective of this review was to assess the efficacy and tolerability of analgesics in reducing behavioral and psychological symptoms of dementia (BPSD) among older adults from published randomized controlled trials (RCTs). A literature search was conducted of PubMed, MEDLINE, SCOPUS, PsycINFO, and Cochrane collaboration databases for RCTs in the English language that evaluated the use of analgesics in reducing the severity of BPSD among older adults. Additionally, references of full-text articles that were included in this review were searched for extra studies...
2017: Drugs in Context
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