keyword
MENU ▼
Read by QxMD icon Read
search

dementia review

keyword
https://www.readbyqxmd.com/read/29455710/the-following-abstracts-were-presented-as-posters-at-the-2017-nei-congress
#1
(no author information available yet)
Congratulations to the scientific poster winners: 1 st Place: #178-Gender Differences in Prodromal Symptoms of Dementia 2 nd Place: #146-Effect of Heroin Use on Changes of Brain Functions As Measured by fMRI, a Systematic Review 3 rd Place: #185-Second Generation Antipsychotics and Catatonia: A Literature Review.
February 2018: CNS Spectrums
https://www.readbyqxmd.com/read/29454581/emerging-roles-of-microglial-cathepsins-in-neurodegenerative-disease
#2
REVIEW
Jessica R Lowry, Andis Klegeris
Alzheimer's disease (AD) is one of the leading causes of dementia, and its prevalence is expected to increase dramatically due to the aging global population. Microglia-driven neuroinflammation may contribute to the progression of AD. Microglia, the immune cells of the central nervous system (CNS), become chronically activated by the pathological proteins of AD including amyloid-β peptides (Aβ). Such adversely activated microglia secrete mediators that promote inflammation and damage neurons. Cathepsins are proteases that are expressed by all brain cell types, and most of them are found both intra- and extra-cellularly...
February 15, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29454307/association-between-residual-teeth-number-in-later-life-and-incidence-of-dementia-a-systematic-review-and-meta-analysis
#3
Bumjo Oh, Dong-Hun Han, Kyu-Tae Han, Xibei Liu, Johnson Ukken, Carina Chang, Kiki Dounis, Ji Won Yoo
BACKGROUND: It has been suggested that tooth loss in later life might increase dementia incidence. The objective of this analysis is to systematically review the current evidence on the relationship between the number of remaining teeth and dementia occurrence in later life. METHODS: A search of multiple databases of scientific literature was conducted with relevant parameters for articles published up to March 25th, 2017. Multiple cohort studies that reported the incidence of dementia and residual teeth in later life were found with observation periods ranging from 2...
February 17, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29454102/inflammation-as-a-possible-link-between-dyslipidemia-and-alzheimer-s-disease
#4
REVIEW
Bruno Cabral de Lima Oliveira, Paula Maria Quaglio Bellozi, Helton José Reis, Antônio Carlos Pinheiro de Oliveira
Alzheimer's disease (AD) is the leading cause of dementia worldwide. This pathological condition is characterized not only by Aβ and tau accumulation in the central nervous system (CNS), but also by inflammation, processes that can lead to neurodegeneration. Besides that, other factors may contribute to the development of AD, such as dyslipidemias. Changes in lipid levels can either influence the activity of enzymes related to the protein deposition that occurs in this pathological condition, or enhance the peripheral and CNS immune responses...
February 14, 2018: Neuroscience
https://www.readbyqxmd.com/read/29453960/synaptic-dysfunction-and-altered-excitability-in-c9orf72-als-ftd
#5
Alexander Starr, Rita Sattler
Amyotrophic lateral sclerosis (ALS) is characterized by a progressive degeneration of upper and lower motor neurons, resulting in fatal paralysis due to denervation of the muscle. Due to genetic, pathological and symptomatic overlap, ALS is now considered a spectrum disease together with frontotemporal dementia (FTD), the second most common cause of dementia in individuals under the age of 65. Interestingly, in both diseases, there is a large prevalence of RNA binding proteins (RBPs) that are mutated and considered disease-causing, or whose dysfunction contribute to disease pathogenesis...
February 14, 2018: Brain Research
https://www.readbyqxmd.com/read/29452176/calcium-channel-blocker-use-reduces-incident-dementia-risk-in-elderly-hypertensive-patients-a-meta-analysis-of-prospective-studies
#6
Salman Hussain, Ambrish Singh, Syed Obaidur Rahman, Anwar Habib, Abul Kalam Najmi
Calcium channel blockers (CCBs) are an established class of drug for the management of hypertension. Observational studies have found that CCB use is associated with a reduction in the risk of developing dementia; however, studies have variably linked the CCBs use with the risk of dementia. This meta-analysis aims to assess whether, in elderly hypertensive patients, the use of CCBs alters the risk of developing dementia. We searched PubMed, Embase and Cochrane from August 2013 to 21st August 2017. Studies were screened on the basis of title and abstract...
February 13, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29451934/development-of-a-self-report-checklist-to-assess-dementia-care-by-nurses-in-hospital-settings
#7
Chikako Ikegami, Katsumasa Ota
Nurses working at general hospitals face difficulties in providing dementia care. The current study examined aged care nurses' dementia care practices in the hospital setting and developed a dementia care checklist that nurses can use to review their own care practice. A self-administered questionnaire was given to 676 participants; responses were collected from 595 participants. Exploratory factor analysis identified six factors (e.g., patient understanding prompted by concern and interest for the patient, respect for patients' voluntary behavior, early detection of abnormalities) among the questionnaire's 28 items...
February 13, 2018: Research in Gerontological Nursing
https://www.readbyqxmd.com/read/29451153/effects-of-plasma-lipids-and-statins-on-cognitive-function
#8
REVIEW
Rui Li, Tian-Jun Wang, Pei-Yuan Lyu, Yang Liu, Wei-Hong Chen, Ming-Yue Fan, Jing Xu
Objective: Dementia is the fourth most common cause of death in developed countries. The relationship between plasma lipids and cognitive function is complex and controversial. Due to the increasing life expectancy of the population, there is an urgent need to control vascular risk factors and to identify therapies to prevent and treat both cognitive impairment and dementia. Here, we reviewed the effects of plasma lipids and statins on cognitive function. Data Sources: We searched the PubMed database for research articles published through November 2017 with key words including "plasma lipids," "hyperlipidemia," "hypercholesterolemia," "statins," and "cognition function...
February 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29448953/clinical-prevalence-of-lewy-body-dementia
#9
Joseph P M Kane, Ajenthan Surendranathan, Allison Bentley, Sally A H Barker, John-Paul Taylor, Alan J Thomas, Louise M Allan, Richard J McNally, Peter W James, Ian G McKeith, David J Burn, John T O'Brien
BACKGROUND: The prevalence of dementia with Lewy bodies (DLB) and dementia in Parkinson's disease (PDD) in routine clinical practice is unclear. Prevalence rates observed in clinical and population-based cohorts and neuropathological studies vary greatly. Small sample sizes and methodological factors in these studies limit generalisability to clinical practice. METHODS: We investigated prevalence in a case series across nine secondary care services over an 18-month period, to determine how commonly DLB and PDD cases are diagnosed and reviewed within two regions of the UK...
February 15, 2018: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29446720/electrochemistry-of-alzheimer-disease-amyloid-beta-peptides
#10
Ana-Maria Chiorcea-Paquim, Teodor Adrian Enache, Ana Maria Oliveira-Brett
Alzheimer's disease (AD) is a widespread form of dementia that is estimated to affect 44.4 million people worldwide. AD pathology is closely related to the accumulation of amyloid beta (Aβ) peptides in fibrils and plagues, the small oligomeric intermediate species formed during the Aβ peptides aggregation presenting the highest neurotoxicity. This review discusses the recent advances on the Aβ peptides electrochemical characterisation. The Aβ peptides oxidation at a glassy carbon electrode occurs in one or two steps, depending on the amino acid sequence, length and content...
February 13, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29444850/neurovascular-dysfunction-in-dementia-human-cellular-models-and-molecular-mechanisms
#11
REVIEW
Isobel Parkes, Satyan Chintawar, M Zameel Cader
From the earliest stages of development, when cerebral angiogenesis and neurogenesis are entwined, to the end of life, the interplay between vascular and neural systems of the brain is critical in health and disease. Cerebral microvascular endothelial cells constitute the blood-brain barrier and in concert with pericytes or smooth muscle cells, glia and neurons, integrate into a functional neurovascular unit (NVU). This multicellular NVU maintains homoeostasis of the brain's microenvironment by restricting the entry of systemic pathogens and neurotoxins as well as meeting the metabolic demands of neural activity...
February 14, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29444783/mortality-and-quality-of-death-certification-in-a-cohort-of-patients-with-parkinson-s-disease-and-matched-controls-in-north-wales-uk-at-18-years-a-community-based-cohort-study
#12
Peter Hobson, Jolyon Meara
OBJECTIVE: This investigation reports the cause and the quality of death certification in a community cohort of patients with Parkinson's disease (PD) and controls at 18 years. SETTING: Denbighshire North Wales, UK. PARTICIPANTS: The community-based cohorts consisted of 166 patients with PD and 102 matched controls. PRIMARY OUTCOMES: All-cause mortality was ascertained at 18 years by review of hospitals' primary care records and examination of death certificates obtained from the UK General Register Office...
February 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29444559/concurrent-alzheimer-s-pathology-in-patients-with-clinical-normal-pressure-hydrocephalus
#13
I Jonathan Pomeraniec, Davis G Taylor, Aaron E Bond, M Beatriz Lopes
BACKGROUND: Patients with normal pressure hydrocephalus (NPH) and Alzheimer's dementia (AD) can often present with similar symptoms. NPH remains a clinical diagnosis and there are reported shared underlying dynamics of cerebrospinal fluid (CSF) flow and histopathology with patients with biopsy-proven AD. METHODS: This is a review on the histopathology and cerebrospinal fluid dynamics of both NPH and AD. In a prior study at the University of Virginia, the authors reviewed patients over a 15 year period who were shunted for a preoperative diagnosis of NPH...
February 13, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29444280/prevalence-of-dementia-in-mainland-china-hong-kong-and-taiwan-an-updated-systematic-review-and-meta-analysis
#14
Yu-Tzu Wu, Gemma-Claire Ali, Maëlenn Guerchet, A Matthew Prina, Kit Yee Chan, Martin Prince, Carol Brayne
Background: There are several existing systematic reviews of prevalence of dementia for mainland China, Hong Kong and Taiwan, but several studies have been newly reported. The aim of this study is to update prevalence data in this region and test for variation across geographical areas and time periods using the new dataset. Methods: Twenty prevalence studies identified from World Alzheimer Report 2015 (January 2011-March 2015) and an updated search (March 2015-February 2017) were added to the original dataset (N = 76)...
February 12, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29444208/death-on-demand-an-analysis-of-physician-administered-euthanasia-in-the-netherlands
#15
Robert Preston
Background: Physician-administered euthanasia (PAE) was legalized, along with physician-assisted suicide (PAS), in The Netherlands in 2001. Sources of data: Annual reports of the Dutch Regional Euthanasia Review Committees, the committees' 2015 published Code of Practice and research studies. Areas of agreement: There is a general openness about the practice of PAE/PAS in The Netherlands and an avoidance of misleading euphemisms. The 2001 law also includes arrangements for post-event review of PAE/PAS decisions...
February 12, 2018: British Medical Bulletin
https://www.readbyqxmd.com/read/29441797/animal-assisted-intervention-and-dementia-a-systematic-review
#16
Michelle L Yakimicki, Nancy E Edwards, Elizabeth Richards, Alan M Beck
This review discusses the relationship between animal-assisted interventions (AAI) and behavioral and psychological symptoms of dementia (BPSD). A systematic search was conducted within CINAHL, Web of Science CAB Abstracts, PubMed, Abstracts in Social Gerontology, Google Scholar, and PsycINFO for primary research articles. A total of 32 studies were included in the final review. Variation was noted in study designs and in study setting. Twenty-seven of 32 studies used dogs as the intervention. Agitation/aggression showed a significant decrease in nine of 15 studies...
February 1, 2018: Clinical Nursing Research
https://www.readbyqxmd.com/read/29441485/clinical-spectrum-of-c9orf72-expansion-in-a-cohort-of-huntington-s-disease-phenocopies
#17
Joana Martins, Joana Damásio, Alexandre Mendes, Nuno Vila-Chã, José E Alves, Cristina Ramos, Sara Cavaco, João Silva, Isabel Alonso, Marina Magalhães
The expansion in the C9orf72 gene has been recently reported as a genetic cause of Huntington's disease (HD) phenocopies. We aim to assess the frequency of the C9orf72 gene expansion in a Portuguese HD phenocopies cohort. Twenty HD phenotype-like patients without diagnosis were identified in our institutional database. C9orf72 gene expansion was detected using repeat-primed PCR. Clinical files were reviewed to characterize the phenotype of expansion-positive cases. One patient (5%) was positive for the C9orf72 expansion...
February 13, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29439581/association-between-dementia-severity-and-recommended-lifestyle-changes-a-retrospective-cohort-study
#18
Timothy Thoits, Alison Dutkiewicz, Sarah Raguckas, Michael Lawrence, Jessica Parker, Jacob Keeley, Nicholas Andersen, Martha VanDyken, Maegan Hatfield-Eldred
OBJECTIVE: Early diagnosis of dementia leads to early treatment which is beneficial to patients and the community. We reviewed initial evaluations from the Spectrum Health Medical Group Neurocognitive Clinic (SHMGNC) to evaluate dementia stage at the time of diagnosis. METHODS: We retrospectively reviewed 110 randomly chosen initial evaluations from September 2008 to December 2015 at the SHMGNC. Patients underwent a neurological examination, Montreal Cognitive Assessment, and a battery of neuropsychological testing...
January 1, 2018: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/29439346/chinese-herbal-medicine-for-vascular-dementia-a-systematic-review-and-meta-analysis-of-high-quality-randomized-controlled-trials
#19
Qing-Qing Xu, Chun-Shuo Shan, Yong Wang, Yi-Hua Shi, Qi-Hao Zhang, Guo-Qing Zheng
BACKGROUND: Vascular dementia (VaD) is the second common form of dementia and Chinese herbal medicine (CHM) has been used for aging-related disorders for thousands of years. However, there is still a lack of scientific evidence using CHM for VaD. OBJECTIVE: To conduct a systematic review to assess the current evidence available for the effectiveness and safety of CHM for VaD. METHODS: Six databases were searched for high-quality randomized-controlled clinical trials that met the requirements of at least 4 of the 7 domains of the Cochrane risk of bias tool from their inception to February 2017...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29439338/multi-parametric-classification-of-vascular-cognitive-impairment-and-dementia-the-impact-of-diverse-cerebrovascular-injury-biomarkers
#20
Brittany Lang, Mark S Kindy, F Andrew Kozel, Susan K Schultz, Saeid Taheri
Vascular cognitive impairment and dementia (VCID) is a diagnostic term applied to cognitively impaired individuals with heterogeneous cerebrovascular conditions affecting large and/or small vessels. Individual biomarkers have been identified as instrumental in relating VCID to specific underlying pathologies to better characterize this syndrome. Emerging research to refine panels of biomarkers will increase classification sensitivity and specificity. Refined VCID clustering based on the severity and pathology of vascular injury will permit the development of optimal prevention and treatment strategies...
2018: Journal of Alzheimer's Disease: JAD
keyword
keyword
41700
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"