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https://www.readbyqxmd.com/read/29690920/developing-a-core-outcome-set-for-people-living-with-dementia-at-home-in-their-neighbourhoods-and-communities-study-protocol-for-use-in-the-evaluation-of-non-pharmacological-community-based-health-and-social-care-interventions
#1
Andrew J E Harding, Hazel Morbey, Faraz Ahmed, Carol Opdebeeck, Ying-Ying Wang, Paula Williamson, Caroline Swarbrick, Iracema Leroi, David Challis, Linda Davies, David Reeves, Fiona Holland, Mark Hann, Ingrid Hellström, Lars-Christer Hydén, Alistair Burns, John Keady, Siobhan Reilly
BACKGROUND: The key aim of the study is to establish an agreed standardised core outcome set (COS) for use when evaluating non-pharmacological health and social care interventions for people living at home with dementia. METHODS/DESIGN: Drawing on the guidance and approaches of the Core Outcome Measures in Effectiveness Trials (COMET), this study uses a four-phase mixed-methods design: 1 Focus groups and interviews with key stakeholder groups (people living with dementia, care partners, relevant health and social care professionals, researchers and policymakers) and a review of the literature will be undertaken to build a long list of outcomes...
April 24, 2018: Trials
https://www.readbyqxmd.com/read/29690887/relational-spirituality-and-quality-of-life-2007-to-2017-an-integrative-research-review
#2
REVIEW
Victor Counted, Adam Possamai, Tanya Meade
BACKGROUND: Despite the increasing number of evidence-based research on relational spirituality (RS) and quality of life (QoL) in medical-health research, little is known about the links between RS and QoL outcomes and the mechanisms by which RS aspects are functionally tied to QoL. OBJECTIVE: To determine how RS is perceived/positioned in relation to QoL, we (a) examined recent available data that identify and appraise the links between RS and QoL; (b) identified themes emerging from the association between RS and QoL, and (c) discussed the implications of the effects of RS on QoL outcomes...
April 24, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29689727/vascular-cognitive-impairment-and-the-gut-microbiota
#3
Sinian Li, Yiming Shao, Kanglan Li, Changmei HuangFu, Wenjie Wang, Zhou Liu, Zhiyou Cai, Bin Zhao
Vascular cognitive impairment (VCI), the second most common cause of dementia in elderly people, is a term that refers to all forms of cognitive disorders that can be attributed to cerebrovascular disease such as manifestations of discrete infarctions, brain hemorrhages, and white matter lesions. The gut microbiota (GM) has emerged recently as an essential player in the development of VCI. The GM may affect the brain's physiological, behavioral, and cognitive functions through the brain-gut axis via neural, immune, endocrine, and metabolic pathways...
April 17, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29689716/effects-of-exergaming-in-people-with-dementia-results-of-a-systematic-literature-review
#4
Joeke van Santen, Rose-Marie Dröes, Marije Holstege, Olivier Blanson Henkemans, Annelies van Rijn, Ralph de Vries, Annemieke van Straten, Franka Meiland
BACKGROUND: Physical exercise benefits functioning, health, and well-being. However, people living with dementia in particular hardly engage in exercise. Exergaming (exercise and gaming) is an innovative, fun, and relatively safe way of exercising in a virtual reality or gaming environment. It may help people living with dementia overcome barriers they can experience regarding regular exercise activities. OBJECTIVE: This systematic literature review aims to provide an overview of the cost-effectiveness of exergaming and its effects on physical, cognitive, emotional, and social functioning, as well as the quality of life in people living with dementia...
April 17, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29687167/bri2-as-an-anti-alzheimer-gene
#5
REVIEW
Shuji Matsuda, Takao Senda
There are several theories regarding the etiologies of Alzheimer disease (AD). Considering that all genes responsible for familial AD are amyloid protein precursor (APP) or APP metabolizing enzymes, surely aberrant APP metabolism is crucial to pathogenesis of AD. BRI2, a type II transmembrane protein, binds APP and inhibits all α, β, and γ pathways of APP proteolysis. Crossing AD model mice with BRI2 transgenic or BRI2 knockout mice confirmed that BRI2 is an anti-Alzheimer gene. Mutations of BRI2 are known to cause rare familial dementias in human...
April 23, 2018: Medical Molecular Morphology
https://www.readbyqxmd.com/read/29686602/advancing-stem-cell-models-of-alpha-synuclein-gene-regulation-in-neurodegenerative-disease
#6
REVIEW
Desiree A Piper, Danuta Sastre, Birgitt Schüle
Alpha-synuclein ( non A4 component of amyloid precursor, SNCA, NM_000345.3 ) plays a central role in the pathogenesis of Parkinson's disease (PD) and related Lewy body disorders such as Parkinson's disease dementia, Lewy body dementia, and multiple system atrophy. Since its discovery as a disease-causing gene in 1997, alpha-synuclein has been a central point of scientific interest both at the protein and gene level. Mutations, including copy number variants, missense mutations, short structural variants, and single nucleotide polymorphisms, can be causative for PD and affect conformational changes of the protein, can contribute to changes in expression of alpha-synuclein and its isoforms, and can influence regulation of temporal as well as spatial levels of alpha-synuclein in different tissues and cell types...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29685207/psychiatric-benefits-of-lithium-in-water-supplies-may-be-due-to-protection-from-the-neurotoxicity-of-lead-exposure
#7
Eric E Brown, Philip Gerretsen, Bruce Pollock, Ariel Graff-Guerrero
INTRODUCTION: Lithium is a medication used to treat bipolar disorder and may also prevent cognitive decline and suicide. Lithium is also found naturally, in levels well below clinical doses, in drinking water worldwide, and levels have been inversely associated with rates of psychiatric disorders. Lead (Pb) is another element in the environment but is a toxin of public health concern. Negative effects of chronic lead exposure and possible benefits of environmental lithium exposure appear complementary...
June 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29685175/general-practitioners-knowledge-attitudes-and-experiences-of-managing-behavioural-and-psychological-symptoms-of-dementia-protocol-of-a-mixed-methods-systematic-review-and-meta-ethnography
#8
Aisling A Jennings, Tony Foley, Kieran A Walsh, Alice Coffey, John P Browne, Colin P Bradley
BACKGROUND: In the context of rising dementia prevalence, the workload of general practitioners (GPs) in dementia care is set to increase. However, there are many aspects of dementia care that GPs find challenging. Behavioural and psychological symptoms of dementia (BPSD) affect the majority of people with dementia and is an aspect of dementia care that GPs find particularly difficult to manage. The aim of this mixed methods systematic review is to undertake a synthesis of qualitative and quantitative studies on GPs' knowledge, attitudes and experiences of managing BPSD...
April 23, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29684335/emergence-of-breath-testing-as-a-new-non-invasive-diagnostic-modality-for-neurodegenerative-diseases
#9
REVIEW
N Siva Subramaniam, C S Bawden, H Waldvogel, R M L Faull, G S Howarth, R G Snell
Neurodegenerative diseases (NDDs) are incapacitating disorders that result in progressive motor and cognitive impairment. These disease include Alzheimer's disease the most common cause of dementia, frontotemporal dementia, amyotrophic lateral sclerosis, dementia with Lewy bodies, Parkinson's, Huntington's, Friedreich's ataxia, and prion disease. Dementia causing NDDs impose a high social and economic burden on communities around the world. Rapid growth in knowledge regarding the pathogenic mechanisms and disease-associated biomarkers of these diseases in the past few decades have accelerated the development of new diagnostic methods and therapeutic opportunities...
April 20, 2018: Brain Research
https://www.readbyqxmd.com/read/29680105/utility-based-instruments-for-people-with-dementia-a-systematic-review-and-meta-regression-analysis
#10
REVIEW
Li Li, Kim-Huong Nguyen, Tracy Comans, Paul Scuffham
BACKGROUND: Several utility-based instruments have been applied in cost-utility analysis to assess health state values for people with dementia. Nevertheless, concerns and uncertainty regarding their performance for people with dementia have been raised. OBJECTIVES: To assess the performance of available utility-based instruments for people with dementia by comparing their psychometric properties and to explore factors that cause variations in the reported health state values generated from those instruments by conducting meta-regression analyses...
April 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29679204/efficacy-of-curcumin-for-age-associated-cognitive-decline-a-narrative-review-of-preclinical-and-clinical-studies
#11
REVIEW
Marjana Rahman Sarker, Susan F Franks
Processes such as aberrant redox signaling and chronic low-grade systemic inflammation have been reported to modulate age-associated pathologies such as cognitive impairment. Curcumin, the primary therapeutic component of the Indian spice, Turmeric (Curcuma longa), has long been known for its strong anti-inflammatory and antioxidant activity attributable to its unique molecular structure. Recently, an interest in this polyphenol as a cognitive therapeutic for the elderly has emerged. The purpose of this paper is to critically review preclinical and clinical studies that have evaluated the efficacy of curcumin in ameliorating and preventing age-associated cognitive decline and address the translational progress of preclinical to clinical efficacy...
April 21, 2018: GeroScience
https://www.readbyqxmd.com/read/29678927/digital-technologies-for-the-assessment-of-cognition-a-clinical-review
#12
REVIEW
Amy Chinner, Jasmine Blane, Claire Lancaster, Chris Hinds, Ivan Koychev
Dementia is the most widespread form of neurodegenerative disorder and is associated with an immense societal and personal cost. Prevalence of this disorder is projected to triple worldwide by 2050 leading to an urgent need to make advances in the efficiency of both its care and therapy research. Digital technologies are a rapidly advancing field that provide a previously unavailable opportunity to alleviate challenges faced by clinicians and researchers working in this area. This clinical review aimed to summarise currently available evidence on digital technologies that can be used to monitor cognition...
April 20, 2018: Evidence-based Mental Health
https://www.readbyqxmd.com/read/29678371/tethering-technique-using-bone-screws-and-wire-for-chronic-mandibular-dislocation-a-preliminary-study-of-refractory-cases
#13
N Segami, T Nishimura, K Miyaki, H Adachi
A retrospective study was performed to determine the efficacy of a tethering procedure developed to achieve a more rigid fixation and more reliable outcome in patients with refractory dislocation of the temporomandibular joint. The cases of eight patients with dementia and systemic diseases who underwent this technique were reviewed. In these eight patients, the condyles of 13 joints were ligated using wire between screws placed in the eminence and condylar head. Additional screw-wire ligations were applied to reinforce the restraint of movement in five of the 13 joints with suspected uncontrolled dislocation...
April 17, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29673549/tau-and-neuroinflammation-what-impact-for-alzheimer-s-disease-and-tauopathies
#14
REVIEW
Cyril Laurent, Luc Buée, David Blum
Alzheimer's Disease (AD) is a chronic neurodegenerative disorder and the most common type of dementia (60-80% of cases). In 2016, nearly 44 million people were affected by AD or related dementia. AD is characterized by progressive neuronal damages leading to subtle and latter obvious decline in cognitive functions including symptoms such as memory loss or confusion, which ultimately require full-time medical care. Its neuropathology is defined by the extracellular accumulation of amyloid-β (Aβ) peptide into amyloid plaques, and intraneuronal neurofibrillary tangles (NFT) consisting of aggregated hyper- and abnormal phosphorylation of tau protein...
February 2018: Biomedical Journal
https://www.readbyqxmd.com/read/29672559/what-does-the-general-public-understand-about-prevention-and-treatment-of-dementia-a-systematic-review-of-population-based-surveys
#15
Monica Cations, Gorjana Radisic, Maria Crotty, Kate E Laver
OBJECTIVES: To synthesise results of population surveys assessing knowledge and attitudes about prevention and treatment of dementia. METHODS: MEDLINE, EMBASE, PsycINFO, and grey literature were searched for English language entries published between 2012 and May 2017. Survey questions were grouped using an inductive approach and responses were pooled. RESULTS: Thirty-four eligible studies and four grey literature items were identified. Surveys were conducted in Europe, the US, Eastern Asia, Israel, and Australia...
2018: PloS One
https://www.readbyqxmd.com/read/29672075/the-telephone-effect-overcoming-initiation-deficits-in-two-settings
#16
Kayci L Vickers, Michael E Keesler, Kelli S Williams, Jeremy Y Charles, Roy H Hamilton
PURPOSE: Disorders of motivation substantially impair an individual's ability to communicate with their families, therapists, and doctors. One method of overcoming initiation deficits is by utilizing the telephone effect, which is the ability for individuals with severe motivation deficits to communicate more readily when speaking on a telephone. However, little is available in the extant literature on how this effect works or how best to integrate this into patient care. This article aims to provide the first report of a proposed mechanism underlying the telephone effect and the first published procedures for eliciting this effect...
April 19, 2018: Rehabilitation Psychology
https://www.readbyqxmd.com/read/29671334/alzheimer-disease-non-pharmacological-and-pharmacological-management-of-cognition-and-neuropsychiatric-symptoms
#17
Samantha M Loi, Dhamidhu Eratne, Wendy Kelso, Dennis Velakoulis, Jeffrey Cl Looi
OBJECTIVES: This clinical update review focuses on the management of cognition and the neuropsychiatric features of Alzheimer's disease (AD) and highlights current issues regarding pharmacological and non-pharmacological treatment, putative therapeutics and recent relevant research findings in this area. CONCLUSIONS: AD is a neurodegenerative progressive condition characterised by cognitive impairment and functional decline. Most people with AD will demonstrate neuropsychiatric features, better known as behavioural and psychological symptoms of dementia (BPSD)...
March 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29669461/connected-speech-and-language-in-mild-cognitive-impairment-and-alzheimer-s-disease-a-review-of-picture-description-tasks
#18
Kimberly D Mueller, Bruce Hermann, Jonilda Mecollari, Lyn S Turkstra
INTRODUCTION: The neuropsychological profile of people with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia includes a history of decline in memory and other cognitive domains, including language. While language impairments have been well described in AD dementia, language features of MCI are less well understood. Connected speech and language analysis is the study of an individual's spoken discourse, usually elicited by a target stimulus, the results of which can facilitate understanding of how language deficits typical of MCI and AD dementia manifest in everyday communication...
April 19, 2018: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/29669408/a-systematic-review-of-nonpharmacological-interventions-for-moderate-to-severe-dementia-a-study-protocol-for-a-systematic-review-and-meta-analysis
#19
Riyoung Na, You Joung Kim, Kiwon Kim, Ki Woong Kim
The study is designed as a systematic review on nonpharmacological interventions for patients with moderate to severe dementia. This review will be conducted in accordance with the Cochrane Handbook for Systematic Reviews of Interventions. The following databases will be searched: Cochrane CENTRAL, MEDLINE, EMBASE, CINAHL, PsycINFO, KoreaMED, KMbase, and KISS. The primary outcome will include the effect of the interventions on activities of daily living and behavioral and psychological symptoms of dementia...
April 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29668562/the-association-between-proton-pump-inhibitor-use-with-acute-kidney-injury-and-chronic-kidney-disease
#20
Faisal Kamal, Muhammad A Khan, Miklos Z Molnar, Colin W Howden
Proton pump inhibitors (PPIs) are among the most commonly prescribed medicines and are the mainstay of treatment for gastroesophageal reflux disease. Recently, there has been an increase in the use of these medicines for unclear and inappropriate indications. Although generally well tolerated and considered to be safe, several observational studies have linked PPI use with a variety of conditions such as pneumonia, Clostridium difficile infection, fractures, hypomagnesemia, and dementia. The well-established association between PPIs and acute interstitial nephritis has raised questions about whether they may also cause acute kidney injury and chronic kidney disease...
April 17, 2018: Journal of Clinical Gastroenterology
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