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https://www.readbyqxmd.com/read/29148070/growth-factors-for-diabetic-foot-ulcers-mixed-treatment-comparison-analysis-of-randomized-clinical-trials
#1
Kannan Sridharan, Gowri Sivaramakrishnan
AIMS: Topical growth factors accelerate wound healing in patients with diabetic foot ulcers (DFU). Due to the absence of head to head comparisons, we carried out Bayesian network meta-analysis to compare the efficacy and safety of growth factors. METHODS: Using an appropriate search strategy, randomized controlled trials on topical growth factors compared with standard of care in patients with DFU, were included. Proportion of patients with complete healing was the primary outcome...
November 17, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29145535/atypical-microbial-isolates-from-infected-diabetic-foot-ulcers-a-case-series-from-greece
#2
Maria Demetriou, Nikolaos Papanas, Periklis Panagopoulos, Maria Panopoulou, Efstratios Maltezos
No abstract text is available yet for this article.
July 2017: Review of Diabetic Studies: RDS
https://www.readbyqxmd.com/read/29142122/adaptive-immune-responses-following-senecavirus-a-infection-in-pigs
#3
Mayara F Maggioli, Steve Lawson, Marcelo de Lima, Lok R Joshi, Tatiane C Faccin, Fernando V Bauermann, Diego G Diel
Senecavirus A (SVA), an emerging picornavirus of swine, causes vesicular disease (VD) that is clinically indistinguishable from foot-and-mouth disease (FMD) in pigs. Many aspects of SVA interactions with the host and the host immune responses to infection, however, remain unknown. In the present study, humoral and cellular immune responses to SVA were evaluated following infection in pigs. We show that SVA infection elicited an early and robust neutralizing antibody (NA) response, which coincided with and was strongly correlated with VP2- and VP3-specific IgM responses...
November 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29141466/retrospective-cohort-analysis-of-pedal-procedures-in-the-thrombocytopenic-patient
#4
Brian M Schmidt, Crystal M Holmes
Thrombocytopenia is an important medical condition to understand prior to performing procedures in the foot and ankle. We have set forth to highlight factors a physician should take into consideration before performing procedures in the thrombocytopenic patient. A retrospective cohort analysis at a large academic institution was undertaken utilizing a cohort discovery tool to discover incidence and management strategies for patients with foot-related conditions that require in-office procedures. We demonstrate that a full history and physical are important to guide treatment along with complete blood count testing prior to intervention...
November 1, 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/29140806/florid-granuloma-annulare-like-reaction-in-regional-lymph-nodes-after-regression-of-red-pigment-in-tattoos
#5
Michael D Carter, Jonathan Trites, Shelly A McNeil, Noreen N M Walsh, Martin J Bullock
A healthy 50-year-old woman had a tattoo performed on the posterior aspect of her neck and another on the dorsum of her left foot. Several weeks later, she noted redness, tenderness, and intense pruritis at both tattoo sites. Treatment with cephalexin and hydrocortisone cream was instituted, without success. Within a few months, the red, but not black, pigment had disappeared from both tattoos and was replaced by pale areas of scarring. Persistently enlarged left supraclavicular and suboccipital lymph nodes were excised 7 and 10 months after receipt of the tattoos, respectively...
October 30, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29138622/antimicrobial-efficacy-of-penicillium-amestolkiae-elv609-extract-treated-cotton-fabric-for-diabetic-wound-care
#6
Nur Amiera Syuhada Binti Rozman, Nurhanis Syafiqah Binti Mohd Nor Hamin, Leong Chean Ring, Tan Wen Nee, Mahfuzah Binti Mustapha, Tong Woei Yenn
Diabetes mellitus is a chronic disorder which affects millions of population worldwide. Global estimates published in 2010 reported the world diabetic prevalence as 6.4%, affecting 285 million adults. Foot ulceration and wound infection are major forms of disabilities arising from diabetic diseases. This study was aimed to develop a natural antimicrobial finishing on medical grade textile that meets American Association of Textiles Chemists and Colorists (AATCC) standard. The textile samples were finished with the ethanolic extract of Penicillium amestolkiae elv609, an endophytic fungus isolated from Orthosiphon stamineus Benth (common name: cat's whiskers)...
September 2017: Mycobiology
https://www.readbyqxmd.com/read/29138583/efficacy-of-intravenous-tigecycline-in-patients-with-acinetobacter-complex-infections-results-from-14-phase-iii-and-phase-iv-clinical-trials
#7
Hal Tucker, Michele Wible, Ashesh Gandhi, Alvaro Quintana
Background: Acinetobacter infections, especially multidrug-resistant (MDR) Acinetobacter infections, are a global health problem. This study aimed to describe clinical outcomes in patients with confirmed Acinetobacter spp. isolates who were treated with tigecycline in randomized clinical trials. Materials and methods: Data from 14 multinational, randomized (open-label or double-blind), and active-controlled (except one) Phase III and IV studies were analyzed using descriptive statistics...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29134555/ciprofloxacin-loaded-calcium-alginate-wafers-prepared-by-freeze-drying-technique-for-potential-healing-of-chronic-diabetic-foot-ulcers
#8
Asif Ahmed, Giulia Getti, Joshua Boateng
Calcium alginate (CA) wafer dressings were prepared by lyophilization of hydrogels to deliver ciprofloxacin (CIP) directly to the wound site of infected diabetic foot ulcers (DFUs). The dressings were physically characterized by scanning electron microscopy (SEM), texture analysis (for mechanical and in vitro adhesion properties), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). Further, functional properties essential for wound healing, i.e., porosity, in vitro swelling index, water absorption (Aw), equilibrium water content (EWC), water vapor transmission rate (WVTR), evaporative water loss (EWL), moisture content, in vitro drug release and kinetics, antimicrobial activity, and cell viability (MTT assay) were investigated...
November 13, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29131751/a-diabetic-foot-ulcer-treated-with-hydrogel-and-hyperbaric-oxygen-therapy-a-case-study
#9
P Aguiar, C Amaral, A Rodrigues, A H de Souza
This study reports on the case of an elderly patient, with diabetes, and a bullous wound on the left big toe that led to an amputation of the first and second left toes. The amputation was because of deep injury as it was not able to heal with a conventional treatment. After completing the normal treatment and the removal of a bacterial infection in the lesion, the patient underwent a treatment that was based on a hydrogel gel (0.9% saline solution) and hyperbaric oxygen therapy (HBOT). After 60 sessions of the therapy, almost complete closure of the wound was observed...
November 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29131746/topical-oxygen-therapy-promotes-the-healing-of-chronic-diabetic-foot-ulcers-a-pilot-study
#10
P D Hayes, N Alzuhir, G Curran, I M Loftus
OBJECTIVE: Interventions that can heal or reduce diabetic foot ulcer (DFU) size may reduce the incidence of infection and amputation, and reduce associated social and economic costs. Many chronic wounds exhibit a degree of hypoxia and this leads to a reduction in healing processes including cell division and differentiation, angiogenesis, infection prevention, and collagen production. The aim of this pilot study was to assess the effects of a device supplying continuous oxygen ambulatory therapy on healing in chronic DFUs...
November 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29129453/hepatitis-b-virus-core-particles-containing-multiple-epitopes-confer-protection-against-enterovirus-71-and-coxsackievirus-a16-infection-in-mice
#11
Chunling Huo, Jie Yang, Lei Lei, Lei Qiao, Jiantao Xin, Zishu Pan
Human enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are the two major causative agents of hand-foot-and-mouth disease (HFMD). To investigate novel combined vaccines to prevent EV71 and CA16 infection, we constructed chimeric virus-like particles (tHBc/SPA or tHBc/SP VLPs) displaying conserved epitopes of EV71 (aa 208-222 of VP1 and aa 248-263 of VP2) and CA16 (aa271-285 of VP1) using a truncated hepatitis B virus core carrier (tHBc). Immunization with the chimeric VLPs induced epitope- or virus-specific IgG and neutralization antibodies against EV71 and CA16 in the mice...
November 9, 2017: Vaccine
https://www.readbyqxmd.com/read/29129314/tibiotalocalcaneal-arthrodesis-with-the-hindfoot-arthrodesis-nail-a%C3%A2-prospective-consecutive-series-from-a-single-institution
#12
Bing Howe Lee, Christopher Fang, Remesh Kunnasegaran, Gowreeson Thevendran
Tibiotalocalcaneal arthrodesis (TTCA) is a salvage procedure. We report a series of 20 patients who underwent TTCA using an intramedullary nail. Of the 20 patients, 7 (35%) had diabetes mellitus. The patient experiences and outcomes were analyzed. Their mean age was 61.1 (range 39 to 78) years. The minimum follow-up period was 13 (mean 28, range 13 to 49) months. Surgical indications included diabetic Charcot arthropathy in 7 (35%), hindfoot osteoarthritis in 10 (50%), and severe equinovarus deformity in 3 (15%)...
November 9, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29124905/rapid-and-simple-detection-of-foot-and-mouth-disease-virus-evaluation-of-a-cartridge-based-molecular-detection-system-for-use-in-basic-laboratories
#13
K V Goller, V Dill, M Madi, P Martin, Y Van der Stede, V Vandenberge, B Haas, S Van Borm, F Koenen, C J Kasanga, N Ndusilo, M Beer, L Liu, V Mioulet, B Armson, D P King, V L Fowler
Highly contagious transboundary animal diseases such as foot-and-mouth disease (FMD) are major threats to the productivity of farm animals. To limit the impact of outbreaks and to take efficient steps towards a timely control and eradication of the disease, rapid and reliable diagnostic systems are of utmost importance. Confirmatory diagnostic assays are typically performed by experienced operators in specialized laboratories, and access to this capability is often limited in the developing countries with the highest disease burden...
November 9, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29120300/enterovirus-71-antagonizes-the-antiviral-activity-of-host-stat3-and-il-6r-with-partial-dependence-on-virus-induced-mir-124
#14
Zhangmei Chang, Yan Wang, Liang Bian, Qingqing Liu, Jian-Er Long
Enterovirus 71 (EV71) has caused major outbreaks of hand, foot and mouth disease. EV71 infections increase the production of many host cytokines and pro-inflammatory factors, including interleukin (IL)-6, IL-10 and COX-2. Some of these molecules could stimulate the signal transducer and activator of transcription 3 (STAT3), which plays a key role in regulating host immune responses and several viral diseases. However, the role of STAT3 in EV71 infection remains unknown. This study found that the phosphorylation levels of STAT3 (p(Y705)-STAT3) are closely related to EV71 infection...
November 9, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/29119858/eimeria-taggarti-n-sp-a-novel-coccidian-apicomplexa-eimeriorina-in-the-prostate-of-an-antechinus-flavipes
#15
Jemima Amery-Gale, Joanne Maree Devlin, Liliana Tatarczuch, David Augustine Taggart, David J Schultz, Jenny A Charles, Ian Beveridge
A novel coccidian species was discovered in the prostate of an Antechinus flavipes (yellow-footed antechinus) in South Australia, during the period of post-mating male antechinus immunosuppression and mortality. This novel coccidian is unusual because it develops extra-intestinally and sporulates endogenously within the prostate gland of its mammalian host. Histological examination of prostatic tissue revealed dense aggregations of spherical and thin-walled tetrasporocystic, dizoic sporulated coccidian oocysts within tubular lumina, with unsporulated oocysts and gamogonic stages within the cytoplasm of glandular epithelial cells...
November 10, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/29119440/compassionate-use-of-bacteriophage-therapy-for-foot-ulcer-treatment-as-an-effective-step-for-moving-toward-clinical-trials
#16
Randolph Fish, Elizabeth Kutter, Gordon Wheat, Bob Blasdel, Mzia Kutateladze, Sarah Kuhl
We here present detailed descriptions of successful treatment of a series of diabetic toe ulcers using the Eliava BioPreparations' commercial preparation of the very well-studied anti-staphylococcal bacteriophage Sb-1. This chapter outlines what we feel is an appropriate mechanism to speed movement toward full-scale clinical trials with bacteriophage use to treat wound infections and to help address the crisis in antibiotic resistance.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29119439/bacteriophage-treatment-of-infected-diabetic-foot-ulcers
#17
Vera V Morozova, Yulia N Kozlova, Denis A Ganichev, Nina V Tikunova
Diabetic foot ulcers occur as a common complication of diabetes. Healing of the ulcers is largely delayed by the concomitant infection. Antibiotic treatment of infected ulcers is complicated by formation of microbial biofilms , which are often heterogeneous and resistant to antibiotics. Bacteriophage therapy is considered as an additional approach to the treatment of infected wounds. Here, we describe the basic method of application of bacteriophages for treatment of infected diabetic foot ulcers, including ones that are very large...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29114245/the-selective-interaction-of-pistacia-lentiscus-oil-vs-human-streptococci-an-old-functional-food-revisited-with-new-tools
#18
Germano Orrù, Cristina Demontis, Antonello Mameli, Enrica Tuveri, Pierpaolo Coni, Giuseppina Pichiri, Ferdinando Coghe, Antonella Rosa, Paola Rossi, Guy D'hallewin
Pistacia lentiscus berry oil (LBO) represents a typical vegetal product of the Mediterranean basin that has been formally used in traditional cuisine for 100s of years. In addition to its interesting alimentary properties, this product could represent an interesting candidate in the field of research on the study of new anti-infective agents. In fact, in Mediterranean countries, lentisk oil still continues to be widely used in folk medicine for oral and skin affections, in particular, acute gingivitis, pediatric skin infections such as impetigo and foot plaques, and biofilm related infections often associated with Streptococcus spp...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29113363/involvement-of-inducible-nitric-oxide-synthase-and-mitochondrial-dysfunction-in-the-pathogenesis-of-enterovirus-71-infection
#19
Dejian Dang, Chao Zhang, Rongguang Zhang, Weidong Wu, Shuaiyin Chen, Jingchao Ren, Peng Zhang, Guangyuan Zhou, Demin Feng, Tiantian Sun, Ying Li, Qiaoli Liu, Mengchen Li, Yuanlin Xi, Yuefei Jin, Guangcai Duan
Enterovirus71 (EV71) is recognized as the main causative agent of severe hand, foot and mouth disease (HFMD). However, the pathogenesis of EV71 infection has not been well characterized. Clinical evidence indicated that inducible nitric oxide synthase (iNOS) induction in the lung of HFMD patients contributes to the severe symptoms of pulmonary edema. In the present study, we recruited 142 subjects including HFMD patients and controls, and serum level of nitric oxide (NO) was determined. Next, cellular and animal model were used to further investigate the roles of iNOS and mitochondria damage during EV71 infection...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29110552/antibiotic-resistance-in-diabetic-foot-soft-tissue-infections-a-series-from-greece
#20
Maria Demetriou, Nikolaos Papanas, Periklis Panagopoulos, Maria Panopoulou, Efstratios Maltezos
Diabetic foot infections are a common and serious problem for all health systems worldwide. The aim of this study was to examine the resistance to antibiotics of microorganisms isolated from infected soft tissues of diabetic foot ulcers, using tissue cultures. We included 113 consecutive patients (70 men, 43 women) with a mean age of 66.4 ± 11.2 years and a mean diabetes duration of 14.4 ± 7.6 years presenting with diabetic foot soft tissue infections. Generally, no high antibiotic resistance was observed...
November 1, 2017: International Journal of Lower Extremity Wounds
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