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https://www.readbyqxmd.com/read/29326225/genomic-insights-into-biofilm-forming-enterococcus-faecalis-sk460-isolated-from-a-chronic-diabetic-ulcer-patient
#1
Karthika Suryaletha, Lekshmi Narendrakumar, Joby John, Dinesh Reghunathan, Manoj Prasannakumar, Sabu Thomas
Enterococcus faecalis is recognized as one of the leading pathogens causing nosocomial infections. Here we report a draft genome sequence of Enterococcus faecalis SK460, isolated from a chronic diabetic foot ulcer patient. This strain exhibits various biofilm-associated genes, virulence genes, and antibiotic-resistance genes related to aminoglycoside, macrolide, and tetracycline resistance.
January 11, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29325424/immediate-weight-bearing-after-hallux-valgus-correction-using-locking-plate-fixation-of-the-ludloff-osteotomy-a-retrospective-review
#2
Steven K Neufeld, John J Marcel, Michael Campbell
BACKGROUND: A Ludloff osteotomy is a common procedure used to correct hallux valgus deformities. Traditionally, the osteotomy is stabilized with screws only, thus requiring the patient to be non-weight bearing until healed. There have been no outcome studies analyzing immediate weight bearing after Ludloff osteotomy for hallux valgus. METHODS: Of the 350 patients (390 feet) who underwent a Ludloff osteotomy fixed with a locking plate and prescribed an immediate weight-bearing postoperative protocol, 288 patients (326 feet) were included in the analysis...
January 1, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29324904/prohibitin-plays-a-critical-role-in-enterovirus-71-neuropathogenesis
#3
Issac Horng Khit Too, Isabelle Bonne, Eng Lee Tan, Justin Jang Hann Chu, Sylvie Alonso
A close relative of poliovirus, enterovirus 71 (EV71) is regarded as an important neurotropic virus of serious public health concern. EV71 causes Hand, Foot and Mouth Disease and has been associated with neurological complications in young children. Our limited understanding of the mechanisms involved in its neuropathogenesis has hampered the development of effective therapeutic options. Here, using a two-dimensional proteomics approach combined with mass spectrometry, we have identified a unique panel of host proteins that were differentially and dynamically modulated during EV71 infection of motor-neuron NSC-34 cells, which are found at the neuromuscular junctions where EV71 is believed to enter the central nervous system...
January 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29323107/serological-survey-of-neutralizing-antibodies-to-eight-major-enteroviruses-among-healthy-population
#4
Rui Zhu, Tong Cheng, Zhichao Yin, Dongxiao Liu, Longfa Xu, Yongchao Li, Wei Wang, Jian Liu, Yuqiong Que, Xiangzhong Ye, Qiyi Tang, Qinjian Zhao, Shengxiang Ge, Shuizhen He, Ningshao Xia
Human enteroviruses (EVs) are the most common causative agents infecting human, causing many harmful diseases, such as hand, foot, and mouth disease (HFMD), herpangina (HA), myocarditis, encephalitis, and aseptic meningitis. EV-related diseases pose a serious worldwide threat to public health. To gain comprehensive insight into the seroepidemiology of major prevalent EVs in humans, we firstly performed a serological survey for neutralizing antibodies (nAbs) against Enterovirus A71 (EV-A71), Coxsackie virus A16 (CV-A16), Coxsackie virus A6 (CV-A6), Coxsackie virus A10 (CV-A10), Coxsackie virus B3 (CV-B3), Coxsackie virus B5 (CV-B5), Echovirus 25 (ECHO25), and Echovirus 30 (ECHO30) among the healthy population in Xiamen City in 2016, using micro-neutralization assay...
January 10, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29322324/molecular-mapping-of-qbk1-wd-a-major-qtl-for-bakanae-disease-resistance-in-rice
#5
Sais-Beul Lee, Yeon-Jae Hur, Jun-Hyeon Cho, Jong-Hee Lee, Tae-Heon Kim, Soo-Min Cho, You-Chun Song, Young-Su Seo, Jungkwan Lee, Tae-Sung Kim, Yong-Jin Park, Myung-Kyu Oh, Dong-Soo Park
BACKGROUND: Bakanae or foot rot disease is a prominent disease of rice caused by Gibberella fujikuroi. This disease may infect rice plants from the pre-emergence stage to the mature stage. In recent years, raising rice seedlings in seed boxes for mechanical transplanting has increased the incidence of many seedling diseases; only a few rice varieties have been reported to exhibit resistance to bakanae disease. In this study, we attempted to identify quantitative trait loci (QTLs) conferring bakanae disease resistance from the highly resistant japonica variety Wonseadaesoo...
January 10, 2018: Rice
https://www.readbyqxmd.com/read/29319516/genetic-characterization-of-human-enteroviruses-associated-with-hand-foot-and-mouth-diseases-in-poland-2013-2016
#6
Magdalena Wieczorek, Agnieszka Ciąćka, Arleta Krzysztoszek, Agnieszka Figas, Leszek Szenborn
The objective of the present study was to describe the molecular characteristics of enteroviruses associated with hand, food, and mouth disease (HFMD) in Poland. Clinical material from HFMD cases, that occurred during 2013-2016 were examined. It has been showed that coxsackievirus A6 (CVA6), CVA10 and CVA16 were circulating in the country. Phylogenetic analysis showed that Polish CVA6 strains were divided into two distinct clusters suggesting two independent introductions. This is the first report of CVA6 infections associated with HFMD in Poland...
September 27, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/29316701/the-effect-of-cryopreserved-human-placental-tissues-on-biofilm-formation-of-wound-associated-pathogens
#7
Yong Mao, Anya Singh-Varma, Tyler Hoffman, Sandeep Dhall, Alla Danilkovitch, Joachim Kohn
Biofilm, a community of bacteria, is tolerant to antimicrobial agents and ubiquitous in chronic wounds. In a chronic DFU (Diabetic Foot Ulcers) clinical trial, the use of a human cryopreserved viable amniotic membrane (CVAM) resulted in a high rate of wound closure and reduction of wound-related infections. Our previous study demonstrated that CVAM possesses intrinsic antimicrobial activity against a spectrum of wound-associated bacteria under planktonic culture conditions. In this study, we evaluated the effect of CVAM and cryopreserved viable umbilical tissue (CVUT) on biofilm formation of S...
January 8, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29316689/annual-direct-medical-costs-of-diabetic-foot-disease-in-brazil-a-cost-of-illness-study
#8
Cristiana M Toscano, Tatiana H Sugita, Michelle Q M Rosa, Hermelinda C Pedrosa, Roger Dos S Rosa, Luciana R Bahia
The aim of this study was to estimate the annual costs for the treatment of diabetic foot disease (DFD) in Brazil. We conducted a cost-of-illness study of DFD in 2014, while considering the Brazilian Public Healthcare System (SUS) perspective. Direct medical costs of outpatient management and inpatient care were considered. For outpatient costs, a panel of experts was convened from which utilization of healthcare services for the management of DFD was obtained. When considering the range of syndromes included in the DFD spectrum, we developed four well-defined hypothetical DFD cases: (1) peripheral neuropathy without ulcer, (2) non-infected foot ulcer, (3) infected foot ulcer, and (4) clinical management of amputated patients...
January 8, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29311608/a-novel-rat-cvb1-vp1-monoclonal-antibody-3a6-detects-a-broad-range-of-enteroviruses
#9
Niila V V Saarinen, Jutta E Laiho, Sarah J Richardson, Marie Zeissler, Virginia M Stone, Varpu Marjomäki, Tino Kantoluoto, Marc S Horwitz, Amirbabak Sioofy-Khojine, Anni Honkimaa, Minna M Hankaniemi, Malin Flodström-Tullberg, Heikki Hyöty, Vesa P Hytönen, Olli H Laitinen
Enteroviruses (EVs) are common RNA viruses that cause diseases ranging from rash to paralytic poliomyelitis. For example, EV-A and EV-C viruses cause hand-foot and mouth disease and EV-B viruses cause encephalitis and myocarditis, which can result in severe morbidity and mortality. While new vaccines and treatments for EVs are under development, methods for studying and diagnosing EV infections are still limited and therefore new diagnostic tools are required. Our aim was to produce and characterize new antibodies that work in multiple applications and detect EVs in tissues and in vitro...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29311091/neutralizing-%C3%AE-toxin-accelerates-healing-of-staphylococcus-aureus-infected-wounds-in-normal-and-diabetic-mice
#10
Roger V Ortines, Haiyun Liu, Lily I Cheng, Taylor S Cohen, Heather Lawlor, Abhishek Gami, Yu Wang, Carly A Dillen, Nathan K Archer, Robert J Miller, Alyssa G Ashbaugh, Bret L Pinsker, Mark C Marchitto, Christine Tkaczyk, C Kendall Stover, Bret R Sellman, Lloyd S Miller
Staphylococcus aureus wound infections delay healing and result in invasive complications such as osteomyelitis, especially in the setting of diabetic foot ulcers. In preclinical animal models of S. aureus skin infection, antibody neutralization of α-toxin (AT), a S. aureus secreted pore-forming cytolytic toxin, reduces disease severity by inhibiting skin necrosis and restoring effective host immune responses. However, whether therapeutic neutralization of α-toxin is effective against S. aureus-infected wounds is unclear...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29304937/an-economic-evaluation-of-the-impact-cost-and-medicare-policy-implications-of-chronic-nonhealing-wounds
#11
Samuel R Nussbaum, Marissa J Carter, Caroline E Fife, Joan DaVanzo, Randall Haught, Marcia Nusgart, Donna Cartwright
OBJECTIVE: The aim of this study was to determine the cost of chronic wound care for Medicare beneficiaries in aggregate, by wound type and by setting. METHODS: This retrospective analysis of the Medicare 5% Limited Data Set for calendar year 2014 included beneficiaries who experienced episodes of care for one or more of the following: arterial ulcers, chronic ulcers, diabetic foot ulcers, diabetic infections, pressure ulcers, skin disorders, skin infections, surgical wounds, surgical infections, traumatic wounds, venous ulcers, or venous infections...
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29302933/assessing-the-effect-of-piperacillin-tazobactam-on-hematological-parameters-in-patients-admitted-with-moderate-or-severe-foot-infections
#12
Will Fry, Sean McCafferty, Catherine Gooday, Ian Nunney, Ketan K Dhatariya
INTRODUCTION: Piperacillin/tazobactam is a commonly used antibiotic for the empirical treatment of severe diabetic foot infections. One of the most feared complications of this drug is the development of pancytopenia. The aim of this study was to determine whether the use of piperacillin/tazobactam caused any hematological changes in patients admitted with severe diabetes-related foot infections from a specialist multidisciplinary foot clinic. Specifically, looking at whether it caused anemia, leukopenia, neutropenia, or thrombocytopenia...
January 4, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29301794/surgical-trauma-induces-overgrowth-in-lower-limb-gigantism-regulation-with-use-of-rapamycin-is-promising
#13
Rohan Sebastian Pinto, William David Harrison, Kenneth Graham, Durai Nayagam
We describe an unclassified overgrowth syndrome characterised by unregulated growth of dermal fibroblasts in the lower limbs of a 35-year-old woman. A PIK3CA gene mutation resulted in lower limb gigantism. Below the waist, she weighed 117 kg with each leg measuring over 100 cm in circumference. Her total adiposity was 50% accounted for by her legs mainly. Liposuction and surgical debulking were performed to reduce the size of the limbs but had exacerbated the overgrowth in her lower limbs. Systemic sepsis from an infected foot ulcer necessitated treatment by an above-knee amputation...
January 4, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29299899/clinical-guidelines-for-the-antibiotic-treatment-for-community-acquired-skin-and-soft-tissue-infection
#14
Yee Gyung Kwak, Seong Ho Choi, Tark Kim, Seong Yeon Park, Soo Hong Seo, Min Bom Kim, Sang Ho Choi
Skin and soft tissue infection (SSTI) is common and important infectious disease. This work represents an update to 2012 Korean guideline for SSTI. The present guideline was developed by the adaptation method. This clinical guideline provides recommendations for the diagnosis and management of SSTI, including impetigo/ecthyma, purulent skin and soft tissue infection, erysipelas and cellulitis, necrotizing fasciitis, pyomyositis, clostridial myonecrosis, and human/animal bite. This guideline targets community-acquired skin and soft tissue infection occurring among adult patients aged 16 years and older...
December 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/29298696/enhanced-human-enterovirus-71-infection-by-endocytosis-inhibitors-reveals-multiple-entry-pathways-by-enterovirus-causing-hand-foot-and-mouth-diseases
#15
Meichun Yuan, Jingjing Yan, Jingna Xun, Chong Chen, Yuling Zhang, Min Wang, Wenqi Chu, Zhigang Song, Yunwen Hu, Shuye Zhang, Xiaoyan Zhang
BACKGROUND: Human enterovirus 71 (EV71) was previously known to enter cells through clathrin or caveolar mediated endocytic pathways. However, we observed chlorpromazine (CPZ) or dynasore (DNS), which inhibit clathrin and dynamin mediated endocytosis, did not suppress EV71 cell entry in particular cell types. So the current knowledge of entry mechanisms by EV71 is not complete. METHODS: Viral infection was examined by flow cytometry or end-point dilution assays...
January 3, 2018: Virology Journal
https://www.readbyqxmd.com/read/29297806/extension-of-the-known-host-range-of-intranuclear-coccidiosis-infection-in-three-captive-red-footed-tortoises-chelonoidis-carbonaria
#16
Justin M Stilwell, Natalie K Stilwell, Nicole I Stacy, James F X Wellehan, Lisa L Farina
The intranuclear coccidian parasite of Testudines (TINC) is an emerging pathogen of tortoises. Three captive red-footed tortoises ( Chelonoidis carbonaria) from an isolated collection presented with multiple acute, nonspecific clinical signs. One tortoise died and was diagnosed with intranuclear coccidiosis on histopathology with confirmation by quantitative polymerase chain reaction (qPCR). In addition to tissues where TINC has been previously described, coccidia were identified in the pineal gland, choroid plexus, and testicular Sertoli cells...
December 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/29296915/erythrocyte-%C3%AE-spectrin-can-be-genetically-targeted-to-protect-mice-from-malaria
#17
Patrick M Lelliott, Hong Ming Huang, Matthew W Dixon, Arman Namvar, Adam J Blanch, Vijay Rajagopal, Leann Tilley, Cevayir Coban, Brendan J McMorran, Simon J Foote, Gaetan Burgio
The malaria parasite hijacks host erythrocytes to shield itself from the immune system and proliferate. Red blood cell abnormalities can provide protection from malaria by impeding parasite invasion and growth within the cell or by compromising the ability of parasites to avoid host clearance. Here, we describe 2 N-ethyl-N-nitrosourea-induced mouse lines, SptbMRI26194 and SptbMRI53426 , containing single-point mutations in the erythrocyte membrane skeleton gene, β spectrin (Sptb), which exhibit microcytosis but retain a relatively normal ratio of erythrocyte surface area to volume and are highly resistant to rodent malaria...
December 12, 2017: Blood Advances
https://www.readbyqxmd.com/read/29290295/financial-impact-of-foot-and-mouth-disease-outbreaks-on-pig-farms-in-the-republic-of-korea-2014-2015
#18
Hachung Yoon, Wooseog Jeong, Jun-Hee Han, Jida Choi, Yong-Myung Kang, Yong-Sang Kim, Hong-Sig Park, Tim E Carpenter
The financial impact of foot-and-mouth disease (FMD) that occurred in 180 piggeries (100 farrow-to-finish and 80 fattening farms) confirmed infected during the 2014/2015 epidemic in the Republic of Korea was estimated at the farm level. The median loss due to slaughtering of pigs prior to their expected market weights was US$ 71.8 (uncovered compensation-compensation loss) plus US$ 57.3 (foregone net gain) per pig. Median loss per farm was US$ 27,487 (55.6% of total loss) for compensation and US$ 15,925 (44...
January 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29282795/interplay-of-foot-and-mouth-disease-virus-with-cell-mediated-and-humoral-immunity-of-host
#19
REVIEW
Muhammad Abubakar, Shumaila Manzoor, Afshan Ahmed
Foot and mouth disease virus (FMDV) causes a communicable disease of cloven hoofed animals, resulting in major economic losses during disease outbreaks. Like other members of the Picornaviridae FMDV has a relatively short infectious cycle; initiation of infection and dissemination, with production of infectious virions occurs in less than a week. The components of innate immunity as well as cell-mediated and humoral immunity play a crucial role in control of FMDV. However, it has been shown in vitro using a mouse model that FMDV has evolved certain mechanisms to counteract host immune responses ensuring its survival and spread...
December 28, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29282065/pulmonary-edema-following-central-nervous-system-lesions-induced-by-a-non-mouse-adapted-ev71-strain-in-neonatal-balb-c-mice
#20
Yuefei Jin, Chao Zhang, Rongguang Zhang, Jingchao Ren, Shuaiyin Chen, Meili Sui, Guangyuan Zhou, Dejian Dang, Jiehui Zhu, Huifen Feng, Yuanlin Xi, Haiyan Yang, Guangcai Duan
BACKGROUND: Enterovirus (EV) infection has been a serious health issue in Asia-Pacific region. It has been indicated that the occurrence of fatal hand foot and mouth disease (HFMD) cases following EV71 infection is mainly attributed to pulmonary edema. However, the development of pulmonary disorders after EV71 infection remains largely unknown. To establish an EV71-infected animal model and further explore the underlying association of central nervous system (CNS) invasion with pulmonary edema, we isolated a clinical source EV71 strain (ZZ1350) from a severe case in Henan Province...
December 28, 2017: Virology Journal
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