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melanoma-surgical oncology

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https://www.readbyqxmd.com/read/29136453/randomized-phase-iii-trial-of-adjuvant-therapy-with-locoregional-interferon-beta-versus-surgery-alone-in-stage-ii-iii-cutaneous-melanoma-japan-clinical-oncology-group-study-jcog1309-j-feron
#1
Kenjiro Namikawa, Arata Tsutsumida, Tomonori Mizutani, Taro Shibata, Tatsuya Takenouchi, Shusuke Yoshikawa, Yoshio Kiyohara, Hiroshi Uchi, Masutaka Furue, Dai Ogata, Tetsuya Tsuchida, Naoya Yamazaki
The Dermatologic Oncology Group of Japan Clinical Oncology Group has started a randomized phase III trial to confirm the superiority of adjuvant therapy with locoregional interferon beta in overall survival over surgery alone for patients with pathological stage II/III cutaneous melanoma (JCOG1309). Patients in the interferon beta arm receive intra- or subcutaneous injections of interferon beta directly into the surgical site at a flat dose of 3 million units once per day. Treatment is repeated for 10 consecutive days every 8 weeks for a total of 3 courses during the induction phase, then 1-day injection every 4 weeks for 2...
July 1, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29121185/molecular-characteristics-of-conjunctival-melanoma-using-whole-exome-sequencing
#2
Swarup S Swaminathan, Matthew G Field, David Sant, Gaofeng Wang, Anat Galor, Sander R Dubovy, J William Harbour, Carol L Karp
Importance: Conjunctival melanoma (CM) is a highly aggressive ocular cancer for which treatment options are limited; the molecular pathogenesis is poorly understood. Objective: To identify the molecular characteristics of CM using next-generation whole-exome sequencing (WES). Design, Setting, and Participants: Whole-exome sequencing was performed on tumor DNA extracted from the archived specimens of 5 patients with CM who had been treated with surgical excision between 2006 and 2011...
November 9, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29110018/estimation-of-direct-melanoma-related-costs-by-disease-stage-and-by-phase-of-diagnosis-and-treatment-according-to-clinical-guidelines
#3
Alessandra Buja, Gino Sartor, Manuela Scioni, Antonella Vecchiato, Mario Bolzan, Vincenzo Rebba, Vanna Chiarion Sileni, Angelo Claudio Palozzo, Maria Montesco, Paolo Del Fiore, Vincenzo Baldo, Carlo Riccardo Rossi
Cutaneous melanoma is a major concern in terms of healthcare systems and economics. The aim of this study was to estimate the direct costs of melanoma by disease stage, phase of diagnosis, and treatment according to the pre-set clinical guidelines drafted by the AIOM (Italian Medical Oncological Association). Based on the AIOM guidelines for malignant cutaneous melanoma, a highly detailed decision-making model was developed describing the patient's pathway from diagnosis through the subsequent phases of disease staging, surgical and medical treatment, and follow-up...
November 7, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29100308/integration-of-genomic-transcriptomic-and-functional-profiles-of-aggressive-osteosarcomas-across-multiple-species
#4
Lara E Davis, Sophia Jeng, Matthew N Svalina, Elaine Huang, Janét Pittsenbarger, Emma L Cantor, Noah Berlow, Bernard Seguin, Atiya Mansoor, Shannon K McWeeney, Charles Keller
In complex, highly unstable genomes such as in osteosarcoma, targeting aberrant checkpoint processes (metabolic, cell cycle or immune) may prove more successful than targeting specific kinase or growth factor signaling pathways. Here, we establish a comparative oncology approach characterizing the most lethal osteosarcomas identified in a biorepository of tumors from three different species: human, mouse and canine. We describe the development of a genetically-engineered mouse model of osteosarcoma, establishment of primary cell cultures from fatal human tumors, and a biorepository of osteosarcoma surgical specimens from pet dogs...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098910/impact-of-extended-lymphadenectomy-on-morbidity-and-regional-recurrence-free-survival-in-melanoma-patients
#5
Johannes Baur, Katrin Mathe, Anja Gesierich, Gerhard Weyandt, Armin Wiegering, Christoph-Thomas Germer, Jörg O W Pelz
Introdurction: Current guidelines for malignant melanoma do not set a concrete cut-off limit for the number of lymph nodes to be resected during regional lymph node dissection (LND). Here we investigate if extended LND (ext-LND) has an impact on surgical morbidity and oncological outcome in melanoma patients. MATERIAL AND METHODS: 245 melanoma patients receiving axillary or inguinal LND in curative intention were investigated retrospectively. Ext-LND was defined as axillary LND with 20 or more and inguinal LND with 10 or more resected lymph nodes...
November 3, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29095708/updates-in-the-management-of-sinonasal-mucosal-melanoma
#6
Meghan M Crippen, Suat Kılıç, Jean A Eloy
PURPOSE OF REVIEW: Sinonasal mucosal melanoma (SNMM) is an aggressive cancer with a poor prognosis. Although there is significant study surrounding the treatment of sinonasal malignancies and cutaneous melanomas, the rarity of this tumor has largely precluded robust outcomes analyses. The authors of this review seek to provide an overview of the recent literature related to the treatment of SNMM with added context from our institutional experience with this disease. RECENT FINDINGS: In the surgical management of sinonasal malignancies and SNMM specifically, resection via endoscopic endonasal technique appears to offer comparable oncologic outcomes versus an open approach...
October 31, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29049462/association-of-surgical-approach-and-margin-status-with-oncologic-outcomes-following-gross-total-resection-for-sinonasal-melanoma
#7
Zafar Sayed, Jocelyn C Migliacci, Jennifer R Cracchiolo, Christopher A Barker, Nancy Y Lee, Sean M McBride, Viviane S Tabar, Ian Ganly, Snehal G Patel, Luc T Morris, Benjamin R Roman, Alexander N Shoushtari, Marc A Cohen
Importance: Sinonasal mucosal melanoma (SMM) is a rare malignant neoplasm characterized by a poor prognosis despite aggressive intervention including wide surgical resection. Margin status has previously been cited as an important prognostic factor for local control and overall survival (OS) in patients who undergo either an open or endoscopic surgical approach. No comparisons have been made, however, in patients who have undergone gross total resection with or without positive margins...
October 19, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29039988/the-intraoperative-use-of-polydioxanone-foil-to-reduce-the-risk-of-sino-orbital-fistula-formation-in-orbital-exenteration
#8
Aws Al-Hity, Maria Elena Gregory, Ewan G Kemp
BACKGROUND: Orbital exenteration is a radical surgical procedure resulting in deformity. It involves removal of the globe, optic nerve, extra-ocular muscles, orbital fat, lacrimal gland, and peri-osteum. Sino-orbital fistula (SOF) formation is a common documented post-operative complication, usually connecting the orbit and the ethmoid sinus. SOFs can cause leaks of serous fluid, and act as an entry site for pathogens into the orbit leading to socket infection and breakdown. METHODS: This retrospective study analyzed exenterations performed over a 22-year period (1993-2015) at the National Ocular Oncology Service Centre for Scotland...
October 17, 2017: Orbit
https://www.readbyqxmd.com/read/28976130/a-retrospective-analysis-of-tolerance-and-outcomes-of-cutaneous-malignant-melanoma-in-patients-receiving-adjuvant-interferon-alpha-2b-a-community-oncology-perspective
#9
Muhammad Zubair Afzal, Vani Pinnamaneni, K C Birendra, Alan T Davis, Tracy J Koehler, Nehal Lakhani
INTRODUCTION: Interferon alpha 2B (IFN-α) therapy in malignant melanoma has improved relapse free survival and overall survival but is considerably toxic and lowers the overall quality of life (QoL) substantially. A significant number of patients do not complete the full duration (one year) of therapy. OBJECTIVE: The aim of this study was to evaluate patients' ability to tolerate IFN-α therapy and to compare our results to reported data in the literature. METHODS: We conducted a retrospective review of patients diagnosed with cutaneous malignant melanoma who received IFN therapy after surgical resection...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28966807/skin-cancer-epidemics-in-the-elderly-as-an-emerging-issue-in-geriatric-oncology
#10
REVIEW
Simone Garcovich, Giuseppe Colloca, Pietro Sollena, Bellieni Andrea, Lodovico Balducci, William C Cho, Roberto Bernabei, Ketty Peris
Skin cancer is a worldwide, emerging clinical need in the elderly white population, with a steady increase in incidence rates, morbidity and related medical costs. Skin cancer is a heterogeneous group of cancers comprising cutaneous melanoma and non-melanoma skin cancers (NMSC), which predominantly affect elderly patients, aged older than 65 years. Melanoma has distinct clinical presentations in the elderly patient and represents a challenging question in terms of clinical management. NMSC includes the basal cell carcinoma and cutaneous squamous cell carcinoma and presents a wide disease spectrum in the elderly population, ranging from low-risk to high-risk tumours, advanced and inoperable disease...
October 2017: Aging and Disease
https://www.readbyqxmd.com/read/28945708/safe-and-effective-standards-of-care-supporting-the-administration-of-t-vec-for-patients-with-advanced-melanoma-in-the-outpatient-oncology-setting%C3%A2
#11
Lisa M Wall, Abigail Baldwin-Medsker
BACKGROUND: Talimogene laherparepvec (T-VEC) is the first oncolytic virus (OV) to demonstrate therapeutic benefit for the treatment of advanced melanoma. As a live virus, the use of T-VEC in medical and surgical outpatient clinics posed challenges. 
. OBJECTIVES: The purpose of this article is to describe the challenges faced when introducing an OV treatment into outpatient clinics and the processes implemented to ensure safety for patients, caregivers, and staff across the care continuum...
October 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28937145/immunoreduction-of-ocular-surface-tumours-with-intralesional-interferon-alpha-2a
#12
S E Kim, S M Salvi
PurposeTo share our initial experience in the use of intralesional interferon alpha-2a at primary presentation in ocular surface tumours as a method of immunoreduction prior to definitive surgical management.MethodsCase series of patients referred to Sheffield Ocular Oncology Service with rapidly growing ocular surface tumours, treated with intralesional interferon alpha-2a at first presentation prior to definitive surgical management.ResultsAll three patients, two with conjunctival melanoma and one with ocular surface squamous neoplasia (OSSN) demonstrated immunoreduction of tumour without any adverse side effects...
September 22, 2017: Eye
https://www.readbyqxmd.com/read/28916919/laparoscopic-liver-resection-for-metastatic-melanoma
#13
Davit L Aghayan, Airazat M Kazaryan, Åsmund Avdem Fretland, Mushegh A Sahakyan, Bård I Røsok, Bjørn Atle Bjørnbeth, Bjørn Edwin
BACKGROUND: Stage IV metastatic melanoma carries a poor prognosis. In the case of melanoma liver metastasis (MLM), surgical resection may improve survival and represents a therapeutic option, with varying levels of success. Laparoscopic liver resection (LLR) for metastatic melanoma is poorly studied. The aim of this study was to analyze the outcomes of LLR in patients with MLM. MATERIALS AND METHODS: Between April 2000 and August 2013, 11 (1 cutaneous, 9 ocular and 1 unknown primary) patients underwent LLR for MLM at Oslo University Hospital-Rikshospitalet and 13 procedures in total were carried out...
September 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28895666/current-standards-of-surgical-management-in-primary-melanoma
#14
Matthew C Perez, Sonia T Orcutt, Jonathan S Zager
Melanoma accounts for the majority of skin cancer-related deaths, and its incidence continues to rise worldwide. While advanced disease has historically been associated with poor long-term survival, early-stage disease has a favorable prognosis and therefore, early diagnosis is paramount. Resection of primary melanoma requires a balance of maximizing oncological outcome while minimizing morbidity. Wide excision with 1-2 cm margins, depending on depth of the tumor, is the standard of care for surgical treatment of primary, invasive melanoma...
September 12, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28868278/conjunctival-melanoma-during-pregnancy
#15
Rana'a T Al-Jamal, Hardeep Singh Mudhar, Zanna Currie, Ian G Rennie, Sachin M Salvi
PURPOSE: To describe the clinical and histopathological features of a conjunctival melanoma (CM) during early pregnancy. PROCEDURES: A 37-year-old, 20-week pregnant primigravida was referred to the Sheffield Ocular Oncology Service with a rapidly growing lesion arising from the right superior conjunctival fornix, noted from the first trimester of pregnancy. This was associated with pain and bloody discharge. Incisional biopsy confirmed the clinical suspicion of invasive CM...
July 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28767408/integration-of-genomic-transcriptomic-and-functional-profiles-of-aggressive-osteosarcomas-across-multiple-species
#16
Lara E Davis, Sophia Jeng, Matthew N Svalina, Elaine Huang, Janét Pittsenbarger, Emma L Cantor, Noah Berlow, Bernard Seguin, Atiya Mansoor, Shannon K McWeeney, Charles Keller
In complex, highly unstable genomes such as in osteosarcoma, targeting aberrant checkpoint processes (metabolic, cell cycle or immune) may prove more successful than targeting specific kinase or growth factor signaling pathways. Here, we establish a comparative oncology approach characterizing the most lethal osteosarcomas identified in a biorepository of tumors from three different species: human, mouse and canine. We describe the development of a genetically-engineered mouse model of osteosarcoma, establishment of primary cell cultures from fatal human tumors, and a biorepository of osteosarcoma surgical specimens from pet dogs...
July 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28724122/association-between-patient-age-and-lymph-node-positivity-in-thin-melanoma
#17
Andrew J Sinnamon, Madalyn G Neuwirth, Pratyusha Yalamanchi, Phyllis Gimotty, David E Elder, Xiaowei Xu, Rachel R Kelz, Robert E Roses, Emily Y Chu, Michael E Ming, Douglas L Fraker, Giorgos C Karakousis
Importance: More than half of all new melanoma diagnoses present as clinically localized T1 melanoma, yet sentinel lymph node biopsy (SLNB) is controversial in this population given the overall low yield. Guidelines for SLNB have focused on pathologic factors, but patient factors, such as age, are not routinely considered. Objectives: To identify indicators of lymph node (LN) metastasis in thin melanoma in a large, generalizable data set and to evaluate the association between patient age and LN positivity...
September 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28679373/a-comprehensive-overview-on-the-surgical-management-of-secondary-lymphedema-of-the-upper-and-lower-extremities-related-to-prior-oncologic-therapies
#18
REVIEW
Ramon Garza, Roman Skoracki, Karen Hock, Stephen P Povoski
Secondary lymphedema of the upper and lower extremities related to prior oncologic therapies, including cancer surgeries, radiation therapy, and chemotherapy, is a major cause of long-term morbidity in cancer patients. For the upper extremities, it is most commonly associated with prior oncologic therapies for breast cancer, while for the lower extremities, it is most commonly associated with oncologic therapies for gynecologic cancers, urologic cancers, melanoma, and lymphoma. Both non-surgical and surgical management strategies have been developed and utilized, with the primary goal of all management strategies being volume reduction of the affected extremity, improvement in patient symptomology, and the reduction/elimination of resultant extremity-related morbidities, including recurrent infections...
July 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28650579/reconstruction-using-a-perforator-free-flap-after-malignant-melanoma-resection-of-the-ankle-and-foot
#19
Young C Suh, Hyunsuk P Suh, Jong S Lee, Jee S Chang, Joon P Jp Hong
BACKGROUND: Surgical excision with adequate margin is the treatment of choice to provide best chance for survival. However, tumors located on distal lower extremity may require reconstruction to salvage the limb which may affect prognosis and quality of life. This retrospective study aimed to evaluate the effect of free flap on overall outcomes of patients with primary malignant melanoma located on the foot and ankle. METHODS: Patients with primary malignant melanoma on the leg and foot who required free flap coverage between August 2005 and January 2014 were evaluated...
June 26, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28644156/clinical-case-of-the-month-a-57-year-old-man-with-an-axillary-mass
#20
Palak Desai, Andrew Myers, Brian Boulmay, Fred A Lopez
A 57-year-old man presented to the surgical oncology clinic with a mildly tender mass under his right arm. Four years prior, the patient had a melanoma removed from his right shoulder along with an ipsilateral right axillary sentinel lymph sampling. Computed tomography (CT) scan was negative for metastatic disease at that time. The patient did not undergo completion axillary node dissection and was lost to follow-up. The patient was originally from Australia, did not tan but reported multiple sunburns before age 18...
May 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
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