keyword
https://read.qxmd.com/read/38546551/neoadjuvant-dual-checkpoint-inhibitors-vs-anti-pd1-therapy-in-high-risk-resectable-melanoma-a-pooled-analysis
#1
JOURNAL ARTICLE
Ankit Mangla, Chanmi Lee, Matthew M Mirsky, Margaret Wang, Luke D Rothermel, Richard Hoehn, Jeremy S Bordeaux, Bryan T Carrol, Jason Theuner, Shawn Li, Pingfu Fu, John M Kirkwood
IMPORTANCE: Despite the clear potential benefits of neoadjuvant therapy, the optimal neoadjuvant regimen for patients with high-risk resectable melanoma (HRRM) is not known. OBJECTIVE: To compare the safety and efficacy of dual checkpoint inhibitors with anti-programmed cell death protein-1 (anti-PD1) therapy in a neoadjuvant setting among patients with HRRM. DESIGN, SETTING, AND PARTICIPANTS: In this pooled analysis of clinical trials, studies were selected provided they investigated immune checkpoint inhibitor treatment, were published between January 2018 and March 2023, and were phase 1, 2, or 3 clinical trials...
March 28, 2024: JAMA Oncology
https://read.qxmd.com/read/38536583/aso-author-reflections-lymphoedema-related-to-inguinal-and-ilioinguinal-lymphadenectomy-for-melanoma
#2
JOURNAL ARTICLE
T S Lee, A J Spillane
No abstract text is available yet for this article.
March 27, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38533993/a-national-database-analysis-of-the-evolution-of-outcomes-of-surgery-for-anal-melanoma
#3
JOURNAL ARTICLE
Sameh H Emile, Nir Horesh, Zoe Garoufalia, Rachel Gefen, Justin Dourado, Steven D Wexner
BACKGROUND: This study assessed trends in treatment and outcomes of anal melanomas over a 17-year period. METHODS: NCDB was searched for patients with anal melanoma (2004-2020). Receiver-operating characteristic curve analysis was used to determine cutoff year marking increased overall survival (OS) of anal melanoma. Characteristics, treatments, and outcomes in consecutive time periods were compared. RESULTS: A total of 815 patients (mean age: 67...
March 27, 2024: Journal of Surgical Oncology
https://read.qxmd.com/read/38533520/intraoperative-near-infrared-spectroscopy-can-predict-skin-flap-necrosis
#4
JOURNAL ARTICLE
W F Hill, K Kinaschuk, C Temple-Oberle
BACKGROUND: The study aimed to validate the previously identified capacity of near-infrared spectroscopy (NIRS) to detect clinically relevant differences in tissue perfusion intraoperatively. METHODS: Consecutive patients undergoing oncologic resection requiring flap reconstruction were analyzed. Clinicians were blinded to tissue oxygen saturation (StO2 ) measurements taken intraoperatively. Measurements were taken at (1) control areas not affected by the procedure, (2) areas at risk of necrosis based on distal location, and (3) areas of skin flap necrosis (SFN) identified during the follow-up period...
March 2024: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/38516457/surgical-management-of-primary-thoracic-epidural-melanoma
#5
Taha Khalilullah, Giancarlo Mignucci-Jiménez, Henry Huffman, Hasita Karthikeyan, Zaheer Hanif, Ogechukwu Ariwodo, Ripul R Panchal
In this study, we reported one of the first cases where a rare robotic-assisted platform with neuronavigation technology and carbon-fiber-polyetheretherketone (CF/PEEK) screws is employed to surgically treat multilevel thoracic primary spinal epidural melanoma. A 67-year-old male presented with left upper thoracic pain. His magnetic resonance imaging (MRI) of the thoracic spine revealed a dumbbell-shaped left epidural mass at the T2-3 level. Partial resection was performed due to tumor growth into the vertebral bodies and patient discretion for minimal surgery...
February 2024: Curēus
https://read.qxmd.com/read/38512416/head-and-neck-mucosal-melanoma-where-are-we-now
#6
REVIEW
Curtis Hanba, Ehab Hanna
PURPOSE OF REVIEW: To highlight recent and relevant treatment considerations while managing mucosal melanoma. RECENT FINDINGS: Evidence is building to support the use of targeted therapy and immunotherapy while managing mucosal melanoma. Surgical resection with postoperative radiotherapy plays a major role in managing resectable disease. Recent studies evaluate the addition of targeted, and immunotherapies with an attempt to determine the most efficacious sequence of treatment...
March 21, 2024: Current Oncology Reports
https://read.qxmd.com/read/38511039/-99m-tc-tilmanocept-vs-sulfur-colloid-for-sentinel-node-biopsy-for-melanoma-in-the-head-and-neck
#7
JOURNAL ARTICLE
Navdeep R Sayal, Jeffrey Schafer, Christopher Jayne, Ansar Wali, Robert Lindau, Harlan Sayles, Alissa Marr, Sarah Aurit, William Lydiatt, Andrew Holcomb, Oleg Militsakh, Andrew Coughlin, Angela Osmolak, Aru Panwar
The objective of the study is to compare sentinel lymph node (SLN) identification rates and performance characteristics of lymphoscintigraphy using 99m Tc-sulfur colloid (SC) and 99m Tc-tilmanocept (TL) for head and neck cutaneous melanoma. This study is a retrospective study, conducted at a single, tertiary care cancer center. Patients underwent sentinel lymph node biopsy (SLNB) for head and neck cutaneous melanoma, using SC or TL, between October 2014 and February 2019. Differences in SLN identification rates and performance characteristics between the groups were examined using the Mann-Whitney, or Fisher's exact test...
March 2024: Indian Journal of Surgical Oncology
https://read.qxmd.com/read/38511025/desmoplastic-melanoma-of-the-chest-wall-a-diagnostic-dilemma
#8
Adil Aziz Khan, Sufian Zaheer, Parth Gulati, Sana Ahuja
Desmoplastic melanoma is an extremely rare subtype of malignant melanoma comprising only 1% of all the cutaneous melanomas. Being amelanotic and owing to its histopathological features of spindle cells lying in a collagenized stroma, it is often misdiagnosed as a dermatofibroma or scar tissue. The present case study describes a case of desmoplastic melanoma of the chest wall where the final diagnosis could be arrived at only after an extensive immunohistochemical panel to exclude other spindle cell proliferations...
March 2024: Indian Journal of Surgical Oncology
https://read.qxmd.com/read/38500654/review-of-recent-advances-in-managing-periocular-skin-malignancies
#9
REVIEW
Daniel C Trotier, Leslie Huang, Suzanne W van Landingham, Adam R Burr, Vincent T Ma
Management of cutaneous malignancies can be particularly challenging when they are located in the periocular region. The standard of care for localized disease is complete surgical excision, but this may not be possible without significant disruption to visual structures and facial appearance. Definitive radiation may be an option for some patients who cannot or do not wish to undergo surgery. Advances in systemic treatment options for locally advanced and metastatic skin cancers in the past 10 years have prompted investigation into neoadjuvant treatment of periocular cancers...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38494565/leg-lymphoedema-after-inguinal-and-ilio-inguinal-lymphadenectomy-for-melanoma-results-from-a-prospective-randomised-trial
#10
JOURNAL ARTICLE
T S Lee, I Li, B Peric, R P M Saw, J P Duprat, E Bertolli, J B Spillane, B L van Leeuwen, M Moncrieff, A Sommariva, C P Allan, J H W de Wilt, R Pritchard- Jones, J L C Geh, J R Howle, A J Spillane
BACKGROUND: The Evaluation of Groin Lymphadenectomy Extent for Melanoma (EAGLE FM) study sought to address the question of whether to perform inguinal (IL) or ilio-inguinal lymphadenectomy (I-IL) for patients with inguinal nodal metastatic melanoma who have no clinical or imaging evidence of pelvic disease. Primary outcome measure was disease-free survival at 5 years, and secondary endpoints included lymphoedema. METHODS: EAGLE FM was designed to recruit 634 patients but closed with 88 patients randomised because of slow recruitment and changes in melanoma management...
March 17, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38493679/the-effect-of-a-single-dose-of-nivolumab-prior-to-isolated-limb-perfusion-for-patients-with-in-transit-melanoma-metastases-an-interim-analysis-of-a-phase-ib-ii-randomized-double-blind-placebo-controlled-trial-nivoilp-trial
#11
JOURNAL ARTICLE
Carl-Jacob Holmberg, Lisanne P Zijlker, Dimitrios Katsarelias, Anne E Huibers, Michel W J M Wouters, Yvonne Schrage, Sophie J M Reijers, Johannes V van Thienen, Dirk J Grünhagen, Anna Martner, Jonas A Nilsson, Alexander C J van Akkooi, Lars Ny, Winan J van Houdt, Roger Olofsson Bagge
OBJECTIVE: ILP has shown to achieve high response rates in patients with melanoma ITM. Possibly there is a synergistic mechanism of action of ILP and anti-PD1. The aim of this trial was to investigate the safety and efficacy of adding a single dose of systemic anti-PD1 to isolated limb perfusion (ILP) for patients with melanoma in-transit metastases (ITM). METHODS: In this placebo controlled double-blind phase Ib/II trial, patients with melanoma ITM were randomized 1:1 to either a single systemic dose of nivolumab or placebo one day prior to ILP...
March 12, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38472947/the-many-hidden-faces-of-gallbladder-carcinoma-on-ct-and-mri-imaging-from-a-to-z
#12
JOURNAL ARTICLE
Damaris Neculoiu, Lavinia Claudia Neculoiu, Ramona Mihaela Popa, Rosana Mihaela Manea
Gallbladder carcinoma represents the most aggressive biliary tract cancer and the sixth most common gastrointestinal malignancy. The diagnosis is a challenging clinical task due to its clinical presentation, which is often non-specific, mimicking a heterogeneous group of diseases, as well as benign processes such as complicated cholecystitis, xanthogranulomatous cholecystitis, adenomyomatosis, porcelain gallbladder or metastasis to the gallbladder (most frequently derived from melanoma, renal cell carcinoma)...
February 22, 2024: Diagnostics
https://read.qxmd.com/read/38468341/metastatic-melanoma-to-small-bowel-metastasectomy-is-supported-in-the-era-of-immunotherapy-and-checkpoint-inhibitors
#13
JOURNAL ARTICLE
Paul Wong, Andrew D Wisneski, Katy K Tsai, Tammy T Chang, Kenzo Hirose, Eric K Nakakura, Adil I Daud, Ajay V Maker, Carlos U Corvera
BACKGROUND: Metastatic melanoma to the small bowel is an aggressive disease often accompanied by obstruction, abdominal pain, and gastrointestinal bleeding. With advancements in melanoma treatment, the role for metastasectomy continues to evolve. Inclusion of novel immunotherapeutic agents, such as checkpoint inhibitors, into standard treatment regimens presents potential survival benefits for patients receiving metastasectomy. CASE PRESENTATION: We report an institutional experience of 15 patients (12 male, 3 female) between 2014-2022 that underwent small bowel metastasectomy for metastatic melanoma and received perioperative systemic treatment...
March 11, 2024: World Journal of Surgical Oncology
https://read.qxmd.com/read/38436625/distinct-presentation-of-melanoma-in-black-patients-may-inform-strategies-to-improve-outcomes
#14
REVIEW
Jessica A Steadman, Amy E Glasgow, Nikki N Neequaye, Elizabeth B Habermann, Tina J Hieken
INTRODUCTION: Melanoma guidelines stem largely from data on non-Hispanic White (NHW) patients. We aimed to identify features of melanoma within non-Hispanic Black (NHB) patients to inform strategies for earlier detection and treatment. METHODS: From 2004 to 2019 Surveillance, Epidemiology, and End Results (SEER) data, we identified nonmetastatic melanoma patients with known TN category and race. Kaplan-Meier cancer-specific survival (CSS) estimates and multivariable Cox proportional hazard modeling analyses were performed...
March 4, 2024: Journal of Surgical Oncology
https://read.qxmd.com/read/38436610/sentinel-lymph-node-biopsy-for-melanoma-in-the-older-population-a-prospective-analysis-of-outcomes
#15
JOURNAL ARTICLE
Murtaza Kadhum, Laura Mayr, Sophie Pope-Jones, Jonathan Cubitt, Sarah Hemington-Gorse
BACKGROUND: The use of sentinel lymph node biopsy (SLNB) in the older population, defined as those over 70 years old, has been debated since the adoption of SLNB into routine practice. Interestingly, there remains a paucity of evidence, especially regarding the rates of SLNB positivity, complications, and subsequent adjuvant therapy in those with node positivity. METHOD: Data on patient's comorbidities, positivity rates, complication rates, and subsequent adjuvant treatments were collected prospectively from 998 patients (644 patients < 70 and 354 patients ≥ 70 years old) between 2016 and 2022...
March 4, 2024: Journal of Surgical Oncology
https://read.qxmd.com/read/38433798/keystone-flap-for-closure-of-skin-cancer-defects-on-the-upper-extremity
#16
JOURNAL ARTICLE
Travis Gordon, Andrew P Golin, Alexander Anzarut
Background: We sought to examine the efficacy of the Keystone Design Perforator Island Flap (KDPIF) for the reconstruction of skin cancer excision defects isolated to the upper extremity. In particular, to examine the size of defects repaired and the complications associated with the keystone flap procedure isolated to the upper extremity. Methods: This is a retrospective chart review including all patients older than 18 years of age who received a KDPIF procedure between February 2013 and February 2019 for the oncologic reconstruction of skin cancer defects isolated to the upper extremities by a single surgeon...
February 2024: Plastic Surgery
https://read.qxmd.com/read/38429650/radar-guided-localization-and-resection-for-metastatic-nodal-and-soft-tissue-melanoma-a-single-institution-retrospective-study
#17
JOURNAL ARTICLE
Kate E Beekman, Danielle K DePalo, Lily M Parker, Kelly M Elleson, John E Mullinax, Amod A Sarnaik, Vernon K Sondak, Jonathan S Zager
BACKGROUND: Radar-guided localization (RGL) offers a wire-free, nonradioactive surgical guidance method consisting of a small percutaneously-placed radar reflector and handheld probe. This study investigates the feasibility, timing, and outcomes of RGL for melanoma metastasectomy. METHODS: We retrospectively identified patients at our cancer center who underwent RGL resection of metastatic melanoma between December 2020-June 2023. Data pertaining to patients' melanoma history, management, reflector placement and retrieval, and follow-up was extracted from patient charts and analyzed using descriptive statistics...
2024: Cancer Control: Journal of the Moffitt Cancer Center
https://read.qxmd.com/read/38418655/assessment-of-social-vulnerabilities-of-care-and-prognosis-in-adult-ocular-melanomas-in-the-us
#18
JOURNAL ARTICLE
Joshua A Mensah, David J Fei-Zhang, Jennifer L Rossen, Bahram Rahmani, David J Bentrem, Joshua D Stein, Dustin D French
BACKGROUND: Prior works have studied the impact of social determinants on various cancers but there is limited analysis on eye-orbit cancers. Current literature tends to focus on socioeconomic status and race, with sparse analysis of interdisciplinary contributions. We examined social determinants as measured by the Centers for Disease Control and Prevention (CDC) Social Vulnerability Index (SVI), quantifying eye and orbit melanoma disparities across the United States. METHODS: A retrospective review of 15,157 patients diagnosed with eye-orbit cancers in the Surveillance, Epidemiology, and End Results (SEER) database from 1975 to 2017 was performed, extracting 6139 ocular melanomas...
February 28, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38401915/precision-oncology-in-melanoma-and-skin-cancer-surgery
#19
REVIEW
Shoshana Levi, Hannah Bank, John Mullinax, Genevieve Boland
There has been perhaps no greater advance in the prognosis of solid tumors in the last decade than for patients with metastatic melanoma. This is due to significant improvements in treatment based on two key components of melanoma tumor biology (1) the identification of driver mutations with therapeutic potential and (2) the mechanistic understanding of a tumor-specific immune response. With breakthrough findings in such a relatively short period of time, the treatment of patients with metastatic melanoma has become intensely personalized...
April 2024: Surgical Oncology Clinics of North America
https://read.qxmd.com/read/38401910/targeted-therapies-biologics-and-immunotherapy-in-the-neoadjuvant-and-adjuvant-settings-perioperative-risks
#20
REVIEW
Daisuke Nishizaki, Ramez N Eskander
Cancer therapeutics has been revolutionized by the introduction of molecularly targeted therapies and immune checkpoint inhibitors (ICIs). The paradigm of neoadjuvant therapy is commonly employed across multiple solid tumors, exhibiting significant clinical benefit as exemplified with ICIs in melanoma and non-small-cell lung cancer. However, neoadjuvant therapy can be associated with treatment-related adverse events. As the incorporation of these novel therapies in the preoperative space expands, it is crucial for surgical oncologists to understand the potential perioperative implications of these treatments...
April 2024: Surgical Oncology Clinics of North America
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