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https://www.readbyqxmd.com/read/28145103/extracapsular-dissection-as-sole-therapy-for-small-low-grade-malignant-tumors-of-the-parotid-gland
#1
Konstantinos Mantsopoulos, Michael Koch, Heinrich Iro
OBJECTIVE: The aim of the study was to investigate whether extracapsular dissection of a primarily unsuspected lesion in the parotid gland could be oncologically sufficient for carefully selected cases of parotid gland malignomas. STUDY DESIGN: Retrospective clinical study. METHODS: The records of all patients treated for primary malignant tumors of the parotid gland solely by means of extracapsular dissection between 2006 and 2013 were studied retrospectively...
January 31, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28137308/therapeutic-implications-of-cellular-and-molecular-biology-of-cancer-stem-cells-in-melanoma
#2
REVIEW
Dhiraj Kumar, Mahadeo Gorain, Gautam Kundu, Gopal C Kundu
Melanoma is a form of cancer that initiates in melanocytes. Melanoma has multiple phenotypically distinct subpopulation of cells, some of them have embryonic like plasticity which are involved in self-renewal, tumor initiation, metastasis and progression and provide reservoir of therapeutically resistant cells. Cancer stem cells (CSCs) can be identified and characterized based on various unique cell surface and intracellular markers. CSCs exhibit different molecular pattern with respect to non-CSCs. They maintain their stemness and chemoresistant features through specific signaling cascades...
January 30, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28135150/phase-iii-randomized-study-of-4-weeks-of-high-dose-interferon-%C3%AE-2b-in-stage-t2bno-t3a-bno-t4a-bno-and-t1-4n1a-2a-microscopic-melanoma-a-trial-of-the-eastern-cooperative-oncology-group-american-college-of-radiology-imaging-network-cancer-research-group-e1697
#3
Sanjiv S Agarwala, Sandra J Lee, Waiki Yip, Uma N Rao, Ahmad A Tarhini, Gary I Cohen, Douglas S Reintgen, Terry L Evans, Joanna M Brell, Mark R Albertini, Michael B Atkins, Shaker R Dakhil, Robert M Conry, Jeffrey A Sosman, Lawrence E Flaherty, Vernon K Sondak, William E Carson, Michael G Smylie, Alberto S Pappo, Richard F Kefford, John M Kirkwood
Purpose To test the efficacy of 4 weeks of intravenous (IV) induction with high-dose interferon (IFN) as part of the Eastern Cooperative Oncology Group regimen compared with observation (OBS) in patients with surgically resected intermediate-risk melanoma. Patients and Methods In this intergroup international trial, eligible patients had surgically resected cutaneous melanoma in the following categories: (1) T2bN0, (2) T3a-bN0, (3) T4a-bN0, and (4) T1-4N1a-2a (microscopic). Patients were randomly assigned to receive IFN α-2b at 20 MU/m(2)/d IV for 5 days (Monday to Friday) every week for 4 weeks (IFN) or OBS...
January 30, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28067922/-reconstructieve-facial-surgery-in-facial-defects-after-the-surgical-removal-of-malignant-skin-tumours
#4
S Bolouri, F Bierenbroodspot, J Jansma
Because of the enormous and continuing increase in cases of skin cancer in the Netherlands, dentists will increasingly see patients with skin cancer. The most common malignant skin cancers are basal cell carcinoma, squamous cell carcinoma and malignant melanoma. With resection of a skin tumour, the oncological principles should be applied. For the closure of the resulting defect, a choice for the individual patient is made out of numerous techniques. Facial reconstructive surgery aims to restore the face in form and function and to maintain the patient's quality of life...
January 2017: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/28052685/occurrence-of-malignancies-after-kidney-transplantation-in-adults-slovak-multicenter-experience
#5
Z Zilinska, M Sersenova, M Chrastina, J Breza Sr, L Bena, T Baltesova, A Jurcina, R Roland, E Lackova, M Cellar, L Laca, I Dedinska
Malignancies are one of the three major causes of renal recipient´s death with a functioning graft after cardiovascular diseases and infections. Among the variety of risk factors, including conventional and specific to transplant recipients, the duration of immunosuppressive therapy, the intensity of therapy, and the type of immunosuppressive agent all have an impact on development of post-transplant malignancy. The aim of our retrospective study was to document the incidence, the type of malignancies, the patient/graft survival in the group of kidney transplant recipients in Slovak Republic, and to identify the factors which influenced the outcome...
January 5, 2017: Neoplasma
https://www.readbyqxmd.com/read/28034500/introduction-to-the-special-issue-of-european-journal-of-surgical-oncology-new-roads-in-melanoma-management
#6
EDITORIAL
P Rutkowski
No abstract text is available yet for this article.
December 14, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28009745/safety-and-feasibility-of-minimally-invasive-inguinal-lymph-node-dissection-in-patients-with-melanoma-safe-milnd-report-of-a-prospective-multi-institutional-trial
#7
James W Jakub, Alicia M Terando, Amod Sarnaik, Charlotte E Ariyan, Mark B Faries, Sabino Zani, Heather B Neuman, Nabil Wasif, Jeffrey M Farma, Bruce J Averbook, Karl Y Bilimoria, Travis E Grotz, Jacob B Jake Allred, Vera J Suman, Mary Sue Brady, Douglas Tyler, Jeffrey D Wayne, Heidi Nelson
BACKGROUND: Minimally invasive inguinal lymph node dissection (MILND) is a novel approach to inguinal lymphadenectomy. SAFE-MILND (NCT01500304) is a multicenter, phase I/II clinical trial evaluating the safety and feasibility of MILND for patients with melanoma in a group of surgeons newly adopting the procedure. METHODS: Twelve melanoma surgeons from 10 institutions without any previous MILND experience, enrolled patients into a prospective study after completing specialized training including didactic lectures, participating in a hands-on cadaveric laboratory, and being provided an instructional DVD of the procedure...
January 2017: Annals of Surgery
https://www.readbyqxmd.com/read/27861329/porous-versus-nonporous-orbital-implants-after-enucleation-for-uveal-melanoma-a-randomized-study
#8
Vivian W M Ho, Rumana N Hussain, Gabriela Czanner, Julia Sen, Heinrich Heimann, Bertil E Damato
PURPOSE: To compare hydroxyapatite with acrylic implants after enucleation for uveal melanoma with respect to eyelid position, ocular motility, implant complications, and patient satisfaction. METHODS: Patients undergoing primary enucleation for uveal melanoma between May 2005 and November 2012 at the Liverpool Ocular Oncology Centre, United Kingdom, were randomized between hydroxyapatite and acrylic implants. Questionnaires were sent to patients and ocularists to comment on the main outcomes...
November 17, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27857516/sentinel-lymph-node-scintigraphy-in-cutaneous-melanoma-using-a-planar-calibration-phantom-filled-with-tc-99m-pertechnetate-solution-for-body-contouring
#9
Claudiu Peştean, Elena Bărbuş, Andra Piciu, Maria Iulia Larg, Alexandrina Sabo, Cristina Moisescu-Goia, Doina Piciu
BACKGROUND AND AIMS: Melanoma is a disease that has an increasing incidence worldwide. Sentinel lymph node scintigraphy is a diagnostic tool that offers important information regarding the localization of the sentinel lymph nodes offering important input data to establish a pertinent and personalized therapeutic strategy. The golden standard in body contouring for sentinel lymph node scintigraphy is to use a planar flood source of Cobalt-57 (Co-57) placed behind the patients, against the gamma camera...
2016: Clujul Medical (1957)
https://www.readbyqxmd.com/read/27690700/the-role-of-minimally-invasive-surgery-in-the-treatment-of-lung-metastases
#10
Gian Piero Guerrini, Felice Lo Faso, Alessio Vagliasindi, Rosalba Lembo, Luciano Solaini, Paolo Soliani, Mario Taviani, Calogero Porrello
INTRODUCTION: The ideal surgical approach for pulmonary metastasectomy remains controversial. Thoracoscopic surgery may offer advantages in quality of life outcomes, with equivalent oncologic long-term results. This study aimed to demonstrate the validity of video-assisted thoracoscopic surgery (VATS) in the treatment of lung metastases. METHODS: In all 224 patients who underwent 300 VATS metastasectomies from January 2000 to December 2013 were retrospectively reviewed...
October 3, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/27690655/percutaneous-surgery-for-treatment-of-epidural-spinal-cord-compression-and-spinal-instability-technical-note
#11
Claudio E Tatsui, Telmo A B Belsuzarri, Marilou Oro, Laurence D Rhines, Jing Li, Amol J Ghia, Behrang Amini, Heron Espinoza, Paul D Brown, Ganesh Rao
OBJECTIVE An emerging paradigm for treating patients with epidural spinal cord compression (ESCC) caused by metastatic tumors is surgical decompression and stabilization, followed by stereotactic radiosurgery. In the setting of rapid progressive disease, interruption or delay in return to systemic treatment can lead to a negative impact in overall survival. To overcome this limitation, the authors introduce the use of spinal laser interstitial thermotherapy (sLITT) in association with percutaneous spinal stabilization to facilitate a rapid return to oncological treatment...
October 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27667577/brain-metastases-surgical-treatment-and-overall-survival
#12
Giancarlo D'Andrea, Lucia Palombi, Giuseppe Minniti, Alessandro Pesce, Paolo Marchetti
BACKGROUND: Brain metastases occur in 10%-40% of patients with cancer and are more common than primary brain tumors (30%-40%); their incidence is growing because of improvements in control of systemic disease, better radiologic detection, and prolonged survival. Modern treatment of brain metastases has dramatically changed the expected prognosis. Traditionally, the prognosis has been considered very poor, and patients were referred to palliative treatment because of their terminal stage; however, new prognostic indexes have been proposed to evaluate these patients...
January 2017: World Neurosurgery
https://www.readbyqxmd.com/read/27550617/invasive-scalp-melanoma-role-for-enhanced-detection-through-professional-training
#13
Brendan P Lovasik, Ishna Sharma, Maria C Russell, Grant W Carlson, Keith A Delman, Monica Rizzo
BACKGROUND: Scalp and neck melanomas (SNMs) have a relatively poor prognosis compared to other sites, and represent an anatomically challenging area for detection. The aim of this study was to identify the role of the hairdresser in detection of SNMs. METHODS: A tertiary surgical oncology institutional database was retrospectively reviewed for all patients undergoing resection of a scalp, posterior neck, or retro auricular invasive primary melanoma between 2008 and 2014...
November 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27422583/measuring-the-quality-of-melanoma-surgery-highlighting-issues-with-standardization-and-quality-assurance-of-care-in-surgical-oncology
#14
S Pasquali, A Sommariva, A J Spillane, K Y Bilimoria, C R Rossi
In an attempt to ensure high standards of cancer care, there is increasing interest in determining and monitoring the quality of interventions in surgical oncology. In recent years, this has been particularly the case for melanoma surgery. The vast majority of patients with melanoma undergo surgery. Usually, this is with combinations of wide excision, sentinel lymph node biopsy and lymphadenectomy. The indications for these procedures evolved during a time when no effective systemic adjuvant therapy was available, and whilst the rationale has been sound, the justification for differences in extent and thoroughness has generally been supported by inadequate or low-level evidence...
June 29, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27416736/the-prognostic-role-of-the-surgical-approach-and-adjuvant-therapy-in-operable-mucosal-melanoma-of-the-head-and-neck
#15
GilJoon Lee, Chung-Hwan Baek, Na Yeon Choi, Man Ki Chung
OBJECTIVES: The aim of this study was to investigate the prognostic impact of the surgical approach and adjuvant treatment in operable malignant melanoma of head and neck (MMHN). METHODS: Retrospective reviews of 31 patients who underwent surgery-based treatment with curative intent, either by the endoscopic or external approach, for MMHN were performed to analyze recurrence patterns, salvage modalities, and oncological outcomes (disease-specific survival and disease-free survival)...
March 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/27367293/diagnosis-and-treatment-of-melanoma-european-consensus-based-interdisciplinary-guideline-update-2016
#16
Claus Garbe, Ketty Peris, Axel Hauschild, Philippe Saiag, Mark Middleton, Lars Bastholt, Jean-Jacques Grob, Josep Malvehy, Julia Newton-Bishop, Alexander J Stratigos, Hubert Pehamberger, Alexander M Eggermont
Cutaneous melanoma (CM) is potentially the most dangerous form of skin tumour and causes 90% of skin cancer mortality. A unique collaboration of multi-disciplinary experts from the European Dermatology Forum, the European Association of Dermato-Oncology and the European Organisation of Research and Treatment of Cancer was formed to make recommendations on CM diagnosis and treatment, based on systematic literature reviews and the experts' experience. Diagnosis is made clinically using dermoscopy and staging is based upon the AJCC system...
August 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27296487/validation-of-a-prognostic-staging-for-metastatic-uveal-melanoma-a-collaborative-study-of-the-european-ophthalmic-oncology-group
#17
Tero T Kivelä, Sophie Piperno-Neumann, Laurence Desjardins, Alexander Schmittel, Nikolaos Bechrakis, Edoardo Midena, Serge Leyvraz, Leonidas Zografos, Jean-Daniel Grange, Guillaume Ract-Madoux, Ernest Marshall, Bertil Damato, Sebastian Eskelin
PURPOSE: To validate a staging system for metastatic uveal melanoma that will facilitate planning, reporting, and interpreting the results of clinical trials. DESIGN: Reliability and validity study. METHODS: The performance index, the largest diameter of the largest metastasis and alkaline phosphatase level at the time of diagnosis of metastases, and overall survival of 249 patients from 7 ocular oncology centers who died of dissemination were analyzed...
August 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27290810/-croatian-society-for-medical-oncology-clinical-guidelines-for-diagnosis-treatment-and-follow-up-of-patients-with-melanoma
#18
Davorin Herceg, Daska Stulhofer Buzina, Romana Ceović, Snjezana Dotlić, Ivana Ilić, Sanda Smuđ Orehovec, Gordana Horvatić Herceg, Davor Mijatović, Robert Separović, Tajana Silovski, Damir Vrbanec
Melanoma in the Western world has an increasing incidence. One of the most important factor for the increase in incidence is sporadic, uncontrolled exposure to the sun. The basis for the treatment of primary melanoma is surgical treatment. Treatment of metastatic disease of melanoma in recent years experienced significant changes. BRAF and MEK inhibitors, immunotherapy with programmed cell-death immune checkpoint inhibitors (anti-PD-1-antibodies) are new options for the treatment of metastatic disease. A mulitidisiplinary team of Croatian Society for Medical Oncology provides recommendations for diagnosis, treatment and follow-up of melanoma primarily driven to the discovery of new drugs and therapeutic options, that change the prognosis of patients with metastatic melanoma...
January 2016: Lijec̆nic̆ki Vjesnik
https://www.readbyqxmd.com/read/27249760/surgical-management-and-adjuvant-therapy-for-high-risk-and-metastatic-melanoma
#19
REVIEW
Alexander C J van Akkooi, Michael B Atkins, Sanjiv S Agarwala, Paul Lorigan
Wide local excision is considered routine therapy after initial diagnosis of primary melanoma to reduce local recurrences, but it does not impact survival. Sentinel node staging is recommended for melanomas of intermediate thickness, but it has also not demonstrated any indisputable therapeutic effect on survival. The prognostic value of sentinel node staging has been long established and is therefore considered routine, especially in light of the eligibility criteria for adjuvant therapy (trials). Whether completion lymph node dissection after a positive sentinel node biopsy improves survival is the question of current trials...
2016: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/27231622/compact-solid-state-cmos-single-photon-detector-array-for-in-vivo-nir-fluorescence-lifetime-oncology-measurements
#20
H A R Homulle, F Powolny, P L Stegehuis, J Dijkstra, D-U Li, K Homicsko, D Rimoldi, K Muehlethaler, J O Prior, R Sinisi, E Dubikovskaya, E Charbon, C Bruschini
In near infrared fluorescence-guided surgical oncology, it is challenging to distinguish healthy from cancerous tissue. One promising research avenue consists in the analysis of the exogenous fluorophores' lifetime, which are however in the (sub-)nanosecond range. We have integrated a single-photon pixel array, based on standard CMOS SPADs (single-photon avalanche diodes), in a compact, time-gated measurement system, named FluoCam. In vivo measurements were carried out with indocyanine green (ICG)-modified derivatives targeting the αvβ 3 integrin, initially on a genetically engineered mouse model of melanoma injected with ICG conjugated with tetrameric cyclic pentapeptide (ICG-E[c(RGD f K)4]), then on mice carrying tumour xenografts of U87-MG (a human primary glioblastoma cell line) injected with monomeric ICG-c(RGD f K)...
May 1, 2016: Biomedical Optics Express
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