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https://www.readbyqxmd.com/read/29789702/parallel-descending-dopaminergic-connectivity-of-a13-cells-to-the-brainstem-locomotor-centers
#1
Sandeep Sharma, Linda H Kim, Kyle A Mayr, David A Elliott, Patrick J Whelan
The mesencephalic locomotor region (MLR) is an important integrative area for the initiation and modulation of locomotion. Recently it has been realized that dopamine (DA) projections from the substantia nigra pars compacta project to the MLR. Here we explore DA projections from an area of the medial zona incerta (ZI) known for its role in motor control onto the MLR. We provide evidence that dopaminergic (DAergic) A13 neurons have connectivity to the cuneiform nucleus (CnF) and pedunculopontine tegmental nucleus (PPTg) of the MLR...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29725711/metachronous-multicentric-giant-cell-tumour-of-bone
#2
Navatha Vangala, Shantveer G Uppin, Sobiya Mehnaz Ayesha, K R Harshavardhana, P Chandrasekhar
Metachronous multicentric giant cell tumour (GCT) of bone is rare. We report a case of a 21-year-old man with metachronous multicentric GCTs, with five (including one recurrence) documented lesions reported over a span of 9 years involving various sites, which included the fifth metacarpal bone of the right hand, the intermediate cuneiform bone of the right foot, the left proximal humerus and the lateral malleolus of the right tibia. The radiological appearance of these lesions in these various sites with correlation among clinical history, histopathology and the treatment approach is described in this report...
May 3, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29701104/the-inter-and-intraobserver-reliability-for-the-radiological-parameters-of-flatfoot-before-and-after-surgery
#3
P Bock, M Pittermann, M Chraim, S Rois
Aims Various radiological parameters are used to evaluate a flatfoot deformity and their measurements may differ. The aims of this study were to answer the following questions: 1) Which of the 11 parameters have the best inter- and intraobserver reliability in a standardized radiological setting? 2) Are pre- and postoperative assessments equally reliable? 3) What are the identifiable sources of variation? Patients and Methods Measurements of the 11 parameters were recorded on anteroposterior and lateral weight-bearing radiographs of 38 feet before and after surgery for flatfoot, by three observers with different experience in foot surgery (A, ten years; B, three years; C, third-year orthopaedic resident)...
May 1, 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29685565/decompressive-medial-cuneiform-exostectomy-for-resistant-tibialis-anterior-insertional-tendinopathy
#4
Alan J Laing, Christopher Carr
Distal tibialis anterior tendinopathy, as a clinical entity, has only recently been documented in foot and ankle studies. We report our experience with medial cuneiform decompressive exostectomy and superficial tendon debridement in 14 cases of recalcitrant tibilalis anterior insertional pain. We reviewed 13 patients (14 feet; 12 females, 1 male; mean age 67.9 ± 7.5; range 55 to 80 years) in whom conservative treatment had failed who had undergone debridement of the insertional tibialis anterior tendon and decompressive exostectomy of the medial cuneiform...
May 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29668543/multiple-epstein-barr-virus-associated-smooth-muscle-sarcomas-of-the-gut-in-a-child-treated-for-acute-lymphoblastic-leukemia
#5
Cécile Boulanger, Maëlle de Ville de Goyet, Catherine de Magnée, Sophie Dupont, Christine Galant, An Van Damme, Bénédicte Brichard
A 7-year-old boy with a history of low-risk acute lymphoblastic leukemia developed multiple intussusceptions shortly after the end of maintenance therapy. Explorative laparotomy showed >10 polyps in the small intestine. Histologic examination revealed intestinal smooth muscle sarcomas associated with Epstein-Barr virus. The patient recovered well after partial cuneiform resection of the largest polyps and treatment with sirolimus. This case report indicates that these tumors may arise even after moderate transient immunosuppression and that association with acute lymphoblastic leukemia is possible although rarely described...
April 17, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29619845/contribution-of-medial-cuneiform-osteotomy-to-correction-of-longitudinal-arch-collapse-in-stage-iib-adult-acquired-flatfoot-deformity
#6
Grace C Kunas, Huong T Do, Amiethab Aiyer, Jonathan T Deland, Scott J Ellis
Background Residual forefoot supination after correcting the hindfoot in stage IIb adult-acquired flatfoot deformity can be addressed with a dorsal opening wedge medial cuneiform (Cotton) osteotomy. The amount of correction is generally judged clinically, and there currently are no preoperative guides that can predict the size of graft needed. The aim of this study was to evaluate the correlation between patient and operative factors and the correction achieved with the Cotton osteotomy. METHODS: Seventy-nine feet in 74 patients undergoing Cotton osteotomy as part of flatfoot reconstruction were reviewed retrospectively...
April 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29575922/evaluation-of-the-area-of-the-lisfranc-ligament-damaged-by-screw-fixation
#7
Isaac Fernandez, William M Weiss, Vinod K Panchbhavi
BACKGROUND: A cannulated screw is currently the standard fixation method to reduce and stabilize diastasis at the lisfranc joint following injury. Currently, there is no literature examining the area of the lisfranc ligament damaged by screw placement. The objective of this investigation is to define the area of the ligament damaged by fixation with a 3.5-mm cannulated screw. MATERIALS AND METHODS: Twelve cadaveric feet were dissected to identify the Lisfranc ligament metatarsal insertion site and origin on the medial cuneiform...
March 1, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29526593/distinct-contributions-of-mesencephalic-locomotor-region-nuclei-to-locomotor-control-in-the-freely-behaving-mouse
#8
Nicolas Josset, Marie Roussel, Maxime Lemieux, David Lafrance-Zoubga, Ali Rastqar, Frederic Bretzner
The mesencephalic locomotor region (MLR) has been initially identified as a supraspinal center capable of initiating and modulating locomotion. Whereas its functional contribution to locomotion has been widely documented throughout the phylogeny from the lamprey to humans, there is still debate about its exact organization. Combining kinematic and electrophysiological recordings in mouse genetics, our study reveals that glutamatergic neurons of the cuneiform nucleus initiate locomotion and induce running gaits, whereas glutamatergic and cholinergic neurons of the pedunculopontine nucleus modulate locomotor pattern and rhythm, contributing to slow-walking gaits...
March 19, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29409256/biomechanical-comparison-of-fixation-stability-using-a-lisfranc-plate-versus-transarticular-screws
#9
Nathan C Ho, Sophia N Sangiorgio, Spenser Cassinelli, Stephen Shymon, John Fleming, Virat Agrawal, Edward Ebramzadeh, Thomas G Harris
BACKGROUND: To obtain adequate fixation in treating Lisfranc soft tissue injuries, the joint is commonly stabilized using multiple transarticular screws; however iatrogenic injury is a concern. Alternatively, two parallel, longitudinally placed plates, can be used to stabilize the 1st and 2nd tarsometatarsal joints; however this may not provide adequate stability along the Lisfranc ligament. Several biomechanical studies have compared earlier methods of fixation using plates to the standard transarticular screw fixation method, highlighting the potential issue of transverse stability using plates...
August 23, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29409239/effects-of-wearing-shoes-on-the-feet-radiographic-comparison-of-middle-aged-partially-shod-maasai-women-s-feet-and-regularly-shod-maasai-and-korean-women-s-feet
#10
Jun Young Choi, Heri Babu, Francis Ngimwhichi Joseph, Stephanie Stephanie, Jin Soo Suh
BACKGROUND: Maasai tribe members walk long distances daily either barefoot or wearing traditional shoes made from recycled car tires, without any foot ailments. To figure out the characteristic of their feet, we designed a radiographic comparative study of middle-aged partially shod Maasai women's feet and regularly shod Maasai and Korean women's feet. METHODS: Weight bearing radiographs of bilateral foot and ankle joints from 20 healthy middle-aged bush-living partially shod (PS) Maasai women were obtained...
April 4, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29395331/detection-of-arytenoid-dislocation-using-pixel-valued-cuneiform-movement
#11
Ashley P O'Connell Ferster, Michael C Ferster, Haley Glatthorn, Bartholomew J Bacak, Robert T Sataloff
OBJECTIVES: This study aims to assess utility of pixel-valued movement software in detecting arytenoid dislocation preoperatively. STUDY DESIGN: This is a retrospective analysis. METHODS: Twenty-seven patients diagnosed with unilateral arytenoid dislocation were included. Diagnosis of arytenoid dislocation was confirmed by lack of vocal fold paralysis on preoperative laryngeal electromyography and by intraoperative findings of cricoarytenoid dislocation...
January 24, 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29366872/calcium-binding-protein-secretagogin-specifies-the-microcellular-tegmental-nucleus-and-intermediate-and-ventral-parts-of-the-cuneiform-nucleus-of-the-mouse-and-rat
#12
Toshio Kosaka, Katsuko Kosaka
Secretagogin (SCGN) is a recently discovered calcium binding protein of the EF hand family, cloned from β cells of pancreatic island of Langerhans and endocrine cells of the gastrointestinal gland. SCGN characterizes some particular neuron groups in various regions of the nervous system and is considered as one of the useful neuron subpopulation markers. In the present study we reported that SCGN specifically labelled a particular neuronal cluster in the brainstem of the mice and rats. The comparison of the SCGN immunostaining with the choline acetyltransferase immunostaining and acetylcholinesterase staining clearly indicated that the particular cluster of SCGN positive neurons corresponded to the microcellular tegmental nucleus (MiTg) and the ventral portion of the cuneiform nucleus (CnF), both of which are components of the isthmus...
February 2, 2018: Neuroscience Research
https://www.readbyqxmd.com/read/29342142/midbrain-circuits-that-set-locomotor-speed-and-gait-selection
#13
V Caggiano, R Leiras, H Goñi-Erro, D Masini, C Bellardita, J Bouvier, V Caldeira, G Fisone, O Kiehn
Locomotion is a fundamental motor function common to the animal kingdom. It is implemented episodically and adapted to behavioural needs, including exploration, which requires slow locomotion, and escape behaviour, which necessitates faster speeds. The control of these functions originates in brainstem structures, although the neuronal substrate(s) that support them have not yet been elucidated. Here we show in mice that speed and gait selection are controlled by glutamatergic excitatory neurons (GlutNs) segregated in two distinct midbrain nuclei: the cuneiform nucleus (CnF) and the pedunculopontine nucleus (PPN)...
January 17, 2018: Nature
https://www.readbyqxmd.com/read/29310446/resting-state-fmri-in-primary-sj%C3%A3-gren-syndrome
#14
Wu Xing, Wei Shi, Yueshuang Leng, Xianting Sun, Tingting Guan, Weihua Liao, Xiaoyi Wang
Background The involvement of the central nervous system in primary Sjögren syndrome (pSS) remains controversial. Functional magnetic resonance imaging (fMRI) is a relatively new method that can be applied to investigate the heterogeneity of central nervous system (CNS) involvement in pSS patients through regional homogeneity (ReHo) analysis. Purpose To collect data from pSS patients and healthy controls, and use ReHo analysis to elucidate the neurobiological mechanism of CNS involvement in pSS. Material and Methods Fourteen clinically diagnosed pSS patients and 14 age- and gender-matched healthy controls underwent resting-state fMRI...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29242801/spindle-cell-hemangioma-of-the-midfoot-a-case-report
#15
Tanawat Vaseenon, Jirawat Saengsin, Nuttaya Pattamapaspong, Jongkolnee Settakorn, Dumnoensun Pruksakorn
Introduction: Spindle cell hemangioma (SCH) of the bone (midfoot) is a rare disease, but it can cause symptomatic pain and invade surrounding tissues lead to limb deformities and functional loss. Case Report: We report the case of a 35-year-old woman who experienced a firm mass over the left midfoot for 5 years causing pain and numbness in the foot. Radiographs showed a geographic osteolytic lesion involving calcification of the base of the 2nd and 3rd metatarsals, cuneiforms bones and surrounding soft tissue...
September 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29238575/non-traumatic-isolated-medial-cuneiform-fracture-a-unique-mechanism-of-a-rare-injury
#16
Gabriella Paisan, Steven Magister, Andrew Bridgforth, Seth Yarboro
We report a case of a 23-year-old woman who sustained a stress fracture to the medial cuneiform. Isolated medial cuneiform fractures are extremely rare with less than 10 cases reported in the literature. The patient initially presented to an urgent care facility complaining of right midfoot pain that occurred while running. Radiographs obtained at the time showed no acute abnormality and the patient was told to resume normal activities. Several weeks later, she presented to urgent care again after exercising, this time unable to bear weight and with swelling and ecchymoses of the right foot...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29234180/role-of-the-nitrergic-system-of-the-cuneiform-nucleus-in-cardiovascular-responses-in-urethane-anesthetized-male-rats
#17
Esmaeil Farrokhi, Mohammad Naser Shafei, Abolfazl Khajavirad, Mahmoud Hosseini, Ali Reza Ebrahimzadeh Bideskan
Background: The presence of nitric oxide (NO) in the cuneiform nucleus (CnF) has been previously shown. In this study, NG-nitro-L-arginine methyl ester (L-NAME) (an inhibitor of NO synthase), L-arginine (L-Arg) (a precursor of NO), and sodium nitroprusside (SNP) (a donor of NO) were microinjected into the CnF and cardiovascular responses were investigated. Methods: Seventy male rats were divided into 7 groups (n=10 each): 1) saline, 2 and 3) L-NAME (30 and 90 nmol), 4 and 5) L-Arg (20 and 60 nmol), and 6 and 7) SNP (9 and 27 nmol)...
September 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29230582/a-new-monozoic-tapeworm-parabreviscolex-niepini-n-g-n-sp-cestoda-caryophyllidea-from-schizothoracine-fishes-cyprinidae-schizothoracinae-in-tibet-china
#18
Bing-Wen Xi, Mikuláš Oros, Kai Chen, Jun Xie
A new monozoic cestode, Parabreviscolex niepini n. gen. and n. sp. (Cestoda: Caryophyllidea), is described from the type-host Schizopygopsis younghusbandi Regan, 1905 (Cyprinidae: Schizothoracinae) and Schizothorax waltoni Regan, 1905 (Cyprinidae: Schizothoracinae) in the Yarlung Tsangpo River, the upper tributary of the Brahmaputra River on the Tibetan Plateau. The new genus is placed in the Capingentidae because the vitellarium is situated partly in the medullary and cortical parenchyma, i.e., neither completely external nor internal to inner longitudinal muscles...
February 2018: Parasitology Research
https://www.readbyqxmd.com/read/29198142/comparison-of-intercuneiform-1-2-joint-mobility-between-hallux-valgus-and-normal-feet-using-weightbearing-computed-tomography-and-3-dimensional-analysis
#19
Tadashi Kimura, Makoto Kubota, Naoki Suzuki, Asaki Hattori, Keishi Marumo
BACKGROUND: An association has been reported between hallux valgus and hypermobility of the first ray, but subluxation of the intercuneiform 1-2 joint was also suspected in some cases. However, dynamics of the intercuneiform 1-2 joint has seldom been investigated. This study used weightbearing computed tomography (CT) and a 3-dimensional (3D) analysis system to evaluate displacement of the intercuneiform 1-2 joint, intercuneiform 2-3 joint, and second cuneonavicular joint due to weightbearing in hallux valgus and normal feet...
March 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29185376/effect-of-the-additional-first-ray-osteotomy-on-hindfoot-alignment-after-calcaneal-osteotomy-for-the-correction-of-mild-to-moderate-adult-type-pes-plano-valgus
#20
Jun Young Choi, Seong Mu Cha, Ji Woong Yeom, Jin Soo Suh
PURPOSE: To determine the effect of the additional first ray osteotomy on hindfoot alignment for the correction of pes plano-valgus. METHODS: Data obtained from 37 consecutive patients recruited from 2006 to 2014 who underwent medial displacement calcaneal osteotomy (MDCO) alone (group H) or MDCO followed by medial cuneiform opening wedge osteotomy (MCOWO) (group HF) with a minimum 1-year follow-up were reviewed retrospectively. The mean follow-up periods were 34 and 32 months...
January 1, 2017: Journal of Orthopaedic Surgery
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