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Joonsung Ahn, Tae Whan Kim
The effect of the curved fin top edge on the electrical characteristics of FinFETs was investigated. The curvature radius of the fin top edge for the FinFETs was changed from 0 to 5 nm in order to determine the optimum condition of the electrical characteristics for the devices. The on-current level of the FinFETs with a curvature radius of 5 nm of fin top edge was 24.45% larger than that of the FinFETs with a cuboid fin. The electron current density and the electron mobility of the fin top edge for the FinFETs were larger than those for the FinFETs with a cuboid fin...
March 1, 2018: Journal of Nanoscience and Nanotechnology
K Bušková, D Kuběnová, M Tuček
Fractures of the fifth metatarsal base are among the most common fractures of the foot. They are typically caused by indirect violence during sports activities. This region is also a site where stress fractures occur frequently. Diagnosis is based on the patients medical history, clinical examination and imaging methods. The fundamental imaging method is radiography of the foot in three views. MRI is used primarily for early diagnosis of stress fractures. CT examination is beneficial mainly in complex foot injuries, in order to rule out associated fractures...
2018: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
Hsing-Hao Ho, Ya-Hui Li, Jih-Chin Lee, Chih-Wei Wang, Yi-Lin Yu, Dueng-Yuan Hueng, Hsin-I Ma, Hsian-He Hsu, Chun-Jung Juan
PURPOSE: We estimated the volume of vestibular schwannomas by an ice cream cone formula using thin-sliced magnetic resonance images (MRI) and compared the estimation accuracy among different estimating formulas and between different models. METHODS: The study was approved by a local institutional review board. A total of 100 patients with vestibular schwannomas examined by MRI between January 2011 and November 2015 were enrolled retrospectively. Informed consent was waived...
2018: PloS One
Yuan Zhang, Subo Cai, Scheffer C G Tseng, Ying-Ting Zhu
To expand multi-potent progenitors from human trabecular meshwork (TM), we have created a new optimized method on two-dimensional (2D) followed by three-dimensional (3D) Matrigel in modified embryonic stem cell medium supplemented with 5% fetal bovine serum (MESCM + 5% FBS). The expanded TM cells were small cuboidal cells expressing TM markers such as AQP1, MGP, CHI3L1, and AnkG, embryonic stem cell (ESC) markers such as Oct4, Sox2, Nanog, and ABCG2, and neural crest (NC) markers such as p75NTR, FOXD3, Sox9, Sox10, and MSX1...
February 12, 2018: Scientific Reports
M Cody O'Dell, Nancy A Chauvin, Diego Jaramillo, David M Biko
BACKGROUND: Cuboid fractures are rare, usually occult on initial radiographs and are often underdiagnosed. MRI is more sensitive than radiographs for detecting acute, non-displaced cuboid fractures in adults, but only case reports have described these findings in children. OBJECTIVE: To summarize the MR and clinical features of cuboid fractures and compare MR findings with initial and follow-up radiographs in a cohort of children. MATERIALS AND METHODS: A retrospective search for patients <18 years of age with cuboid fractures was performed during a 10-year period at a large tertiary children's hospital...
February 9, 2018: Pediatric Radiology
Adam J Schindler, Arisa Watanabe, Stephen B Howell
Wnt signaling plays a fundamental role in patterning of the embryo and maintenance of stem cells in numerous epithelia. Epithelial stem cells are closeted in niches created by surrounding differentiated cells that express secreted Wnt and R-spondin proteins that influence proliferation rate and fate determination of stem cell daughters. R-spondins act through the LGR receptors to enhance Wnt signaling. This close association of stem cells with more differentiated regulatory cells expressing Wnt-pathway ligands is a feature replicated in all of the epithelial stem cell systems thus far examined...
January 2, 2018: Oncotarget
Marija Dakovic Bjelakovic, Slobodan Vlajkovic, Milica Bjelakovic
The aim of this study was to determine the developmental characteristics of podocytes in the human fetal metanephros using scanning electron microscopy, light microscopy, and transmission electron microscopy. Kidney samples of 15 human fetuses of both sexes (gestational age 10-22 weeks) were analyzed. At the S-shaped body stage, primitive podocytes were arranged in a layer of cuboidal cells beneath the vascular cleft. When observed from Bowman's space, the demarcation between adjacent podocytes was not clear, but mild depressions indicated cell boundaries...
February 7, 2018: Cells, Tissues, Organs
Tim Rolvien, Jozef Zustin, Michael Amling, Oleg Yastrebov
We report the case of a 35-year-old woman with painful, nontender mass at the right lateral hindfoot. Computed tomography (CT) and magnetic resonance imaging (MRI) indicated the suspect of a chondroid tumour in the cuboid. The tumour was resected en bloc and histology revealed the presence of a periosteal (juxtacortical) chondroma with secondary aneurysmal bone cyst. Secondary hyperparathyroidism was detected in laboratory tests and put into context with the histopathologic findings. In conclusion, a rare case of periosteal chondroma of the cuboid with secondary aneurysmal bone cyst in a setting of secondary hyperparathyroidism due to vitamin D deficiency is presented...
February 2018: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
Masashi Miyaoka, Kazuhito Hatanaka, Masayuki Iwazaki, Naoya Nakamura
We report a rare case of pulmonary enteric adenocarcinoma (PEA) exhibiting a immunohistochemical feature of CK7/CK20 double-negativity by evaluating the transformation zone between PEA and conventional pulmonary adenocarcinoma (CPA). A 75-year-old man was found to have a mass, 40 mm in diameter, in the right lower lobe on chest computed tomography, and underwent right lower lobectomy. Histologically, the tumor was composed of a PEA and CPA component. The dominant PEA component had medium to large complex glands with tall columnar cells with eosinophilic cytoplasm and brush-border...
February 1, 2018: International Journal of Surgical Pathology
Jun Young Choi, Heri Babu, Francis Ngimwhichi Joseph, Stephanie Stephanie, Jin Soo Suh
BACKGROUND: Maasai tribe members walk long distances daily either barefoot or wearing traditional shoes made from recycled car tires, without any foot ailments. To figure out the characteristic of their feet, we designed a radiographic comparative study of middle-aged partially shod Maasai women's feet and regularly shod Maasai and Korean women's feet. METHODS: Weight bearing radiographs of bilateral foot and ankle joints from 20 healthy middle-aged bush-living partially shod (PS) Maasai women were obtained...
April 4, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
L Rony, P De Sainte Hermine, V Steiger, F Ferchaud, P Cronier
INTRODUCTION: Cuboid fractures are very rare. Hence, their treatment has not been standardized. Advances in imaging techniques, particularly three-dimensional computed tomography (3D CT), and the introduction of cuboid-specific plates has improved the care of these injuries. The aim of this study was to determine the radiological and clinical outcomes of anatomical reconstruction of comminuted cuboid fractures with a locking plate. HYPOTHESIS: Fixation of comminuted cuboid fractures with a cuboid-specific locking plate leads to stable anatomical reduction and good functional outcomes...
January 30, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
Ji-Myung Bae, John C Clarke, Harunur Rashid, Mitra D Adhami, Kayla McCullough, Jordan S Scott, Haiyan Chen, Krishna M Sinha, Benoit de Crombrugghe, Amjad Javed
The Sp7/Osterix transcription factor is essential for bone development. Mutations of Sp7 gene in humans are associated with craniofacial anomalies and osteogenesis imperfecta. However, the role of Sp7 in embryonic tooth development remains unknown. Here we identified the functional requirement of Sp7 for dentin synthesis and tooth development. Sp7-null mice exhibit craniofacial dysmorphogenesis and are completely void of alveolar bone. Surprisingly, initial tooth morphogenesis progressed normally in Sp7-null mice...
February 5, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Till Mohr, Andreas Herdt, Wolfgang Elsässer
A 2D tomographic terahertz imaging set-up using a single pixel imaging approach is realized, where a liquid helium cooled bolometer is utilized as a bucket detector and a mercury-arc lamp serves as a broadband terahertz source. The different patterns of the terahertz radiation, which are necessary for the single pixel imaging approach, are realized by spatially addressed photodoping of a high resistivity float zone silicon window, employing a near-infrared laser diode, which is spatially modulated by a digital micromirror device...
February 5, 2018: Optics Express
Andrew Wood, Brendan I Conn
We present 2 further cases of sclerosing microcystic adenocarcinoma occurring in the tongue in 2 female patients, one age 68 years and the other 49 years. Histopathologically, both tumors were characterized by a diffusely infiltrative lesion consisting of small cuboidal cells arranged in discrete dispersed cords, isolated tubules, and bilayered strands with intervening microcystic lumina set in a sclerotic background. Both lesions showed striking neurotropism with perineural and intraneural infiltration. Extensive invasion of adjacent skeletal muscle was also observed...
January 9, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Bandan Chakrabortty, Ikram Blilou, Ben Scheres, Bela M Mulder
Plant morphogenesis is strongly dependent on the directional growth and the subsequent oriented division of individual cells. It has been shown that the plant cortical microtubule array plays a key role in controlling both these processes. This ordered structure emerges as the collective result of stochastic interactions between large numbers of dynamic microtubules. To elucidate this complex self-organization process a number of analytical and computational approaches to study the dynamics of cortical microtubules have been proposed...
February 2, 2018: PLoS Computational Biology
Angeleene S Ang, Alina Karabchevsky, Igor V Minin, Oleg V Minin, Sergey V Sukhov, Alexander S Shalin
Specialized electromagnetic fields can be used for nanoparticle manipulation along a specific path, allowing enhanced transport and control over the particle's motion. In this paper, we investigate the optical forces produced by a curved photonic jet, otherwise known as the "photonic hook", created using an asymmetric cuboid. In our case, this cuboid is formed by appending a triangular prism to one side of a cube. A gold nanoparticle immersed in the cuboid's transmitted field moves in a curved trajectory. This result could be used for moving nanoparticles around obstacles; hence we also consider the changes in the photonic hook's forces when relatively large glass and gold obstacles are introduced at the region where the curved photonic jet is created...
February 1, 2018: Scientific Reports
Md Noushad Javed, Kanchan Kohli, Saima Amin
Statins are widely prescribed for hyperlipidemia, cancer, and Alzheimer's disease but are facing some inherent challenges such as low solubility and drug loading, higher hepatic metabolism, as well as instability at gastric pH. So, relatively higher circulating dose, required for exerting the therapeutic benefits, leads to dose-mediated severe toxicity. Furthermore, due to low biocompatibility, high toxicity, and other regulatory caveats such as product conformity, reproducibility, and stability of conventional formulations as well as preferentially higher bioabsorption of lipids in their favorable cuboidal geometry, enhancement in in vivo biopharmaceutical performance of Rosuvastatin could be well manifested in Quality by Design (QbD) integrated cuboidal-shaped mucoadhesive microcrystalline delivery systems (Limicubes)...
January 31, 2018: AAPS PharmSciTech
Guy W Nicolette
Chronic ankle pain is relatively common in family medicine. Sequelae from lateral ankle sprains are the most common cause. Other etiologies include peroneal tendinopathy or subluxation, osteochondral injury, lateral ankle impingement, sinus tarsi syndrome, cuboid syndrome, bony stress injury, and other unusual factors. A thorough history focusing on the mechanism of injury (if traumatic) and the nature of the pain along with a targeted physical examination typically will provide the information needed to make the diagnosis...
February 2018: FP Essentials
Glenn B Pfeffer, Max P Michalski, Tina Basak, Joseph C Giaconi
BACKGROUND: Cavovarus deformity of the hindfoot is typically caused by neurologic disorders. Multiple osteotomies have been described for the correction of varus deformity but without clinical comparison. In this study, we used 18 identical 3-dimensional (3D) prints of a patient with heel varus to compare the operative correction obtained with Dwyer, oblique, and Z osteotomies. METHODS: A computed tomography (CT) scan of a patient with heel varus was used to create 18 identical 3D prints of the talus, calcaneus, and cuboid...
January 1, 2018: Foot & Ankle International
Wenyi Huang, Jiajia Liu, Bing Bai, Liu Huang, Meng Xu, Jia Liu, Hongpan Rong, Jiatao Zhang
Perovskite nanocrystals (NCs), a good fluorescent candidate for excellent photoelectric properties, have opened new avenues in the fabrication of highly efficient solar cells, light-emitting diodes (LEDs), and other optoelectronic devices. Further advances will rely on the multitude of compositional, structural variants that enable the formation of lower-dimensionality layered and three-dimensional (3D) perovskites with architectural innovations. In this work, the perovskite film was fabricated on the flexible substrate by simple dip-coating technology and 3D assemblies of perovskite NCs were obtained through an attachment process...
January 16, 2018: Nanotechnology
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