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https://www.readbyqxmd.com/read/28107095/chibby1-knockdown-promotes-mesenchymal-to-epithelial-transition-like-changes
#1
Victoria Fischer, Michael Wong, Feng-Qian Li, Ken-Ichi Takemaru
Chibby1 (Cby1) was originally isolated as a binding partner for β-catenin, a dual function protein in cell-cell adhesion and in canonical Wnt signaling. The canonical Wnt/β-catenin pathway is dysregulated in various diseases including cancer, most notably of the gastrointestinal origin. To investigate the role of Cby1 in colorectal tumorigenesis, we generated stable Cby1-knockdown (KD) SW480 colon cancer cells. Unexpectedly, we found that Cby1 KD induces mesenchymal-to-epithelial transition (MET)-like changes in SW480 as well as in HEK293 cells...
January 20, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28105348/thyroid-like-low-grade-nasopharyngeal-papillary-adenocarcinoma-a-case-report
#2
Taro Horino, Osamu Ichii, Kazu Hamada-Ode, Tatsuki Matsumoto, Yoshiko Shimamura, Kosuke Inoue, Yoshio Terada
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is a rare neoplasm characterized by morphological analogy to papillary thyroid carcinoma and abnormal expression of thyroid transcription factor-1 (TTF-1). We herein report a rare case of TL-LGNPPA with a review of its clinical, morphological and immunohistochemical characteristics. The patient was a 25-year-old Japanese woman complaining of a 2-year history of fever of unknown origin. There were no remarkable physical findings and the laboratory tests, including C-reactive protein levels, were normal...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28097642/adrenal-cyst-with-both-m%C3%A3-llerian-and-mesothelial-differentiation-a-clinicopathological-and-immunohistochemical-study-with-implications-for-histogenesis
#3
Łukasz Koperski, Benedykt Szczepankiewicz, Paweł Pihowicz, Łukasz Fus, Ewa Wolińska, Barbara Górnicka
True epithelial-lined cysts are rare forms of adrenal cystic lesions, the pathogenesis of which is still not fully understood. In this report we present a case of an adrenal cyst diagnosed incidentally on imaging in a 31-year-old, previously healthy, obese woman. Due to non-specific hormonal disorders and enlargement of the lesion, a right-sided laparoscopic adrenalectomy was performed. The cyst was lined predominantly by ciliated cuboidal-to-columnar, Müllerian-type epithelium, and focally by flat-to-cuboidal, mesothelium-like lining...
January 18, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28094162/intrahepatic-cholangiocarcinoma
#4
Masayuki Nakano, Shun-Ichi Ariizumi, Masakazu Yamamoto
Cholangiocarcinoma, also referred to as cholangiocellular carcinoma (particularly in Japan), develops along the biliary tract. The tumor may be intra- or extrahepatic and have different features with specific treatments based on the site of origin. Guidelines for diagnosis and management of cholangiorcarcinoma, such as those proposed by EASL (European Association for the Study of the Liver)(1) and the Mayo Clinic(2) classify the tumor into intrahepatic, perihilar, and distal cholangiocarcinoma. There are three main macroscopic patterns of growth of cholangiocarcinoma: mass-forming, periductal-infiltrating and intraductal...
January 5, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28091605/cubosomes-from-hierarchical-self-assembly-of-poly-ionic-liquid-block-copolymers
#5
Hongkun He, Khosrow Rahimi, Mingjiang Zhong, Ahmed Mourran, David R Luebke, Hunaid B Nulwala, Martin Möller, Krzysztof Matyjaszewski
Cubosomes are micro- and nanoparticles with a bicontinuous cubic two-phase structure, reported for the self-assembly of low molecular weight surfactants, for example, lipids, but rarely formed by polymers. These objects are characterized by a maximum continuous interface and high interface to volume ratio, which makes them promising candidates for efficient adsorbents and host-guest applications. Here we demonstrate self-assembly to nanoscale cuboidal particles with a bicontinuous cubic structure by amphiphilic poly(ionic liquid) diblock copolymers, poly(acrylic acid)-block-poly(4-vinylbenzyl)-3-butyl imidazolium bis(trifluoromethylsulfonyl)imide, in a mixture of tetrahydrofuran and water under optimized conditions...
January 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28063645/anisotropy-and-inter-condyle-heterogeneity-of-cartilage-under-large-strain-shear
#6
Stephany Santos, Franz Maier, David M Pierce
We were the first to examine the mechanical responses of skeletally mature bovine femoral cartilage under large-strain simple shear (up to ±20%) using a multiaxial shear testing device. Since shear loading is critical in both tissue failure and chondrocyte responses, we aimed to probe (1) anisotropy with respect to the split-line direction (principal alignment of the collagen fibers near the articulating surface), (2) heterogeneity between femoral condyles, and (3) the influence of local cartilage thickness...
December 30, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/28061467/cytological-study-on-the-regulation-of-lymphocyte-homing-in-the-chicken-spleen-during-lps-stimulation
#7
Qian Zhang, Yasir Waqas, Ping Yang, Xuejing Sun, Yi Liu, Nisar Ahmed, Bing Chen, Quanfu Li, Lisi Hu, Yufei Huang, Hong Chen, Bing Hu, Qiusheng Chen
The immune function of the chicken spleen depends on its different compartments of red and white pulps, but little is known about the mechanism underlying lymphocyte homing towards the different compartments. In the present study, the role of lymphocyte homing in the chicken spleen was investigated during lipopolysaccharide (LPS) stimulation. Morphological analysis demonstrated the cuboidal endothelial cells of the splenic sheathed capillary facilitated the passage of lymphocyte homing to the chicken spleen...
January 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28058662/os-peroneum-imaging-normal-appearance-and-pathological-findings
#8
REVIEW
Stefano Bianchi, Chandra Bortolotto, Ferdinando Draghi
The os peroneum (OP) is a small sesamoid bone located inside the peroneus longus tendon (PLT), close to the cuboid. The OP can be the cause of pain and can be associated with lesions of the PLT. OP involvement in PLT disorders is frequently misdiagnosed by radiologists. Painful os peroneum syndrome (POPS) refers to a variety of conditions presenting with pain localized on the lateral aspect of the cuboid area. The syndrome can be observed as a consequence of local acute trauma such as ankle sprains or chronic overuse...
January 5, 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/28056869/protein-kinase-c-inhibitor-g%C3%A3-6976-but-not-g%C3%A3-6983-induces-the-reversion-of-e-to-n-cadherin-switch-and-metastatic-phenotype-in-melanoma-identification-of-the-role-of-protein-kinase-d1
#9
Messaouda Merzoug-Larabi, Caroline Spasojevic, Marianne Eymard, Caroline Hugonin, Christian Auclair, Manale Karam
BACKGROUND: Melanoma is a highly metastatic type of cancer that is resistant to all standard anticancer therapies and thus has a poor prognosis. Therefore, metastatic melanoma represents a significant clinical problem and requires novel and effective targeted therapies. The protein kinase C (PKC) family comprises multiple isoforms of serine/threonine kinases that possess distinct roles in cancer development and progression. In this study, we determined whether inhibition of PKC could revert a major process required for melanoma progression and metastasis; i...
January 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28047489/su-f-j-154-harmonic-analysis-for-arbitrary-3d-mr-image-distortion-fields
#10
T Stanescu, D Jaffray
PURPOSE: To study the practical feasibility of harmonic analysis for the full quantification of 3D MR image distortion fields associated with arbitrarily-shaped regions of interest. METHODS: The 3D scanner-related distortion field (F) is innate to the MR image data. Since it is implicitly related to the magnetic fields required to perform MR imaging, F is in a steady-state and can be described by a boundary value problem in which the Laplace's equation is solved with Dirichlet boundary conditions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046680/su-f-j-14-kilovoltage-cone-beam-ct-dose-estimation-of-varian-on-board-imager-using-gmctdospp-monte-carlo-framework
#11
S Kim, D Rangaraj
PURPOSE: Although cone-beam CT (CBCT) imaging became popular in radiation oncology, its imaging dose estimation is still challenging. The goal of this study is to assess the kilovoltage CBCT doses using GMctdospp - an EGSnrc based Monte Carlo (MC) framework. METHODS: Two Varian OBI x-ray tube models were implemented in the GMctpdospp framework of EGSnrc MC System. The x-ray spectrum of 125 kVp CBCT beam was acquired from an EGSnrc/BEAMnrc simulation and validated with IPEM report 78...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042751/lateral-foot-pain-in-a-recreational-runner
#12
Brian A Young, Joshua R Kniss, Felix Islas
A 35-year-old male recreational runner with a 9-month history of left lateral foot pain self-referred to physical therapy while awaiting orthopaedic consultation. Before presenting to physical therapy, his primary care physician ordered radiographs and referred him to orthopaedics with a provisional diagnosis of multipartite os peroneum. Following examination, the initial treatment hypothesis was cuboid syndrome, as he met the majority of items in a proposed diagnostic cluster. J Orthop Sports Phys Ther 2017;47(1):41...
January 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28040499/machine-learned-cluster-identification-in-high-dimensional-data
#13
Alfred Ultsch, Jörn Lötsch
BACKGROUND: High-dimensional biomedical data are frequently clustered to identify subgroup structures pointing at distinct disease subtypes. It is crucial, that the used cluster algorithm works correctly. However, by imposing a predefined shape on the clusters, classical algorithms occasionally suggest a cluster structure in homogenously distributed data or assign data points to incorrect clusters. We analyzed whether this can be avoided when using Emergent Self-organizing feature maps (ESOM)...
December 28, 2016: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28036182/shape-induced-deformation-capillary-bridging-and-self-assembly-of-cuboids-at-the-fluid-fluid-interface
#14
Thriveni G Anjali, Madivala G Basavaraj
The controlled assembly of anisotropic particles through shape-induced interface deformations is shown to be a potential route for the fabrication of novel functional materials. In this article, the shape-induced interface deformation, capillary bridging, and directed self-assembly of cuboidal-shaped hematite particles at fluid-fluid interfaces are reported. The multipolar nature of the interface distortions is directly visualized using high-resolution scanning electron microscopy and 3D optical surface profiling...
January 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28035787/cuboid-vesicles-formed-by-frame-guided-assembly-on-dna-origami-scaffolds
#15
Yuanchen Dong, Yuhe Renee Yang, Yiyang Zhang, Dianming Wang, Xixi Wei, Saswata Banerjee, Yan Liu, Zhongqiang Yang, Hao Yan, Dongsheng Liu
We describe the use of a frame-guided assembly (FGA) strategy to construct cuboid and dumbbell-shaped hetero-vesicles on DNA origami nanostructure scaffolds. These are achieved by varying the design of the DNA origami scaffolds that direct the distribution of the leading hydrophobic groups (LHG). By careful selection of LHGs, different types of amphiphiles (both polymer and small-molecule surfactants) were guided to form hetero-vesicles, demonstrating the versatility of the FGA strategy and its potential to construct asymmetric and dynamic hetero-vesicle assemblies with complex DNA nano-scaffolds...
December 30, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/28009885/maximally-dense-random-packings-of-cubes-and-cuboids-via-a-novel-inverse-packing-method
#16
Lufeng Liu, Zhuoran Li, Yang Jiao, Shuixiang Li
The packings of cubes and cuboids (i.e., "elongated" or "compressed" cubes) are ubiquitous in nature. The high symmetry and space-tiling nature of such particles make them easily packable in dense configurations with a high degree of orientational and translational order. In this paper, we devise a novel inverse packing method that enables one to generate dense hard-particle packings with a controllable degree of disorder/order quantified by predefined order metrics via stochastic Monte Carlo optimizations...
December 23, 2016: Soft Matter
https://www.readbyqxmd.com/read/27997524/digital-anatomical-measurement-for-anterolateral-fixation-of-middle-and-lower-thoracic-vertebrae
#17
Xiaohe Li, He En, Yunfeng Zhang, Shang Gao, Guimin Li, Yu Guo, Xin Wang, Haiyan Wang, Yongqiang Cai, Zhiqiang Wang, Zhijun Li, Cunbao Li, Feifei Zhao
: BACKGROUND The key to its successful application is to determine the best entry point for the vertebral screw(s). This study aimed to provide a reference for clinical anterolateral fixation through digital measurement of computed tomography (CT) data to identify relevant anatomical positions in the middle and lower thoracic vertebrae (T4-T12) of 30 adults. MATERIAL AND METHODS We performed digital measurement of anatomical positions in the middle and lower thoracic vertebrae (T4-T12) of 30 adults...
December 20, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27995582/denudation-of-human-amniotic-membrane-by-a-novel-process-and-its-characterisations-for-biomedical-applications
#18
R Sripriya, R Kumar
This study was aimed to investigate the suitability of a modified method to get decellularised human amniotic membrane (DHAM). The obtained membrane was subjected to physico-chemical and biological evaluations to validate its potential for biomedical applications. The human amniotic membrane was processed with detergent and alkali followed by enzymatic treatments. Hematoxylin and eosin (H&E) and Masson's trichrome staining of membrane were in accordance with conjectures: the decellularised membrane stained for extracellular matrix is rich in collagen...
December 2016: Progress in biomaterials
https://www.readbyqxmd.com/read/27993885/pulmonary-adenofibroma-report-of-a-case-with-multiple-masses
#19
Junmei Hao, Cuiping Zhang, Qinghua Cao, Jiarui Zou, Chaofu Wang
We are reporting one case of multiple pulmonary adenofibromas in a 57-year-old non-smoking female. Ten well-circumscribed masses were identified in both lungs. The masses are characterized by gland-like structures lined by a single layer of simple cuboidal or columnar epithelium. The stroma is abundant and demonstrates compact spindle-cells. The epithelial component is generally positive for CK7, TTF-1, Napsin A. The stromal component displays expression of vimentin, desmin, SMA, h-CALD, ER, PR, Bcl-2, and is negative for CD34, CD117, CD99...
December 2016: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/27984235/intraductal-tubulopapillary-neoplasm-of-the-pancreas-a-clinicopathologic-and-immunohistochemical-analysis-of-33-cases
#20
Olca Basturk, Volkan Adsay, Gokce Askan, Deepti Dhall, Giuseppe Zamboni, Michio Shimizu, Karina Cymes, Fatima Carneiro, Serdar Balci, Carlie Sigel, Michelle D Reid, Irene Esposito, Helena Baldaia, Peter Allen, Günter Klöppel, David S Klimstra
Intraductal tubulopapillary neoplasm (ITPN) is a relatively recently described member of the pancreatic intraductal neoplasm family. Thus, the literature on its histologic and immunohistochemical features, clinical behavior, and its similarities and differences from other pancreatic neoplasms is limited. Thirty-three cases of ITPN, the largest series to date, were identified. Immunohistochemical labeling for cytokeratins, glycoproteins, pancreatic enzymes, markers for intestinal and neuroendocrine differentiation, and antibodies associated with genetic alterations previously described in pancreatic neoplasms was performed...
December 14, 2016: American Journal of Surgical Pathology
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