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perineural injections

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https://www.readbyqxmd.com/read/27881053/oxytocin-provides-protection-against-diabetic-polyneuropathy-in-rats
#1
Oytun Erbas, Dilek Taşkıran, Fatih Oltulu, Altuğ Yavaşoğlu, Saylav Bora, Okan Bilge, Bilge Piri Çınar, Gönül Peker
PURPOSE: The aim of the present study is to investigate the protective effects of oxytocin (OT) on diabetic neuropathy (DNP) in rats. MATERIALS AND METHODS: Eighteen rats were used to induce diabetes using single dose streptozotocin (STZ, 60 mg/kg). Diabetic DNP was verified by electromyography (EMG) and motor function test on 21st day following STZ injection. Six rats served as naïve control group and received no drug (n = 6). Following EMG, diabetic rats were randomly divided into three groups and administered with either 1 ml/kg saline or 80 μg/kg OT or 160 μg/kg OT intraperitoneally for four weeks...
November 24, 2016: Neurological Research
https://www.readbyqxmd.com/read/27875620/a-reliable-technique-for-us-guided-perineural-injection-in-ulnar-neuropathy-at-the-elbow
#2
Ulrike M Hamscha, Ines Tinhofer, Stefan Heber, Wolfgang Grisold, Wolfgang J Weninger, Stefan Meng
INTRODUCTION: Ulnar neuropathy at the elbow (UNE) is a common peripheral compression neuropathy and in most cases occurs at 2 sites, the retroepicondylar groove or the cubital tunnel. With regard to a potential therapeutic approach with perineural corticosteroid injection the aim of this study was to evaluate the distribution of injection fluid applied at a standard site. METHODS: We performed ultrasound-guided (US-guided) perineural injections to the ulnar nerve halfway between the olecranon and the medial epicondyle in 21 upper limbs from 11 non-embalmed cadavers...
November 22, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27871587/peripheral-nerve-blocks-in-the-management-of-postoperative-pain-challenges-and-opportunities
#3
REVIEW
Girish Joshi, Kishor Gandhi, Nishant Shah, Jeff Gadsden, Shelby L Corman
Peripheral nerve blocks (PNBs) are increasingly used as a component of multimodal analgesia and may be administered as a single injection (sPNB) or continuous infusion via a perineural catheter (cPNB). We undertook a qualitative review focusing on sPNB and cPNB with regard to benefits, risks, and opportunities for optimizing patient care. Meta-analyses of randomized controlled trials have shown superior pain control and reductions in opioid consumption in patients receiving PNB compared with those receiving intravenous opioids in a variety of upper and lower extremity surgical procedures...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27871553/fascia-iliaca-block-associated-only-with-deep-sedation-in-high-risk-patients-taking-p2y12-receptor-inhibitors-for-intramedullary-femoral-fixation-in-intertrochanteric-hip-fracture-a-series-of-3-cases
#4
Carlos Rodrigues Almeida, Emília Milheiro Francisco, Vítor Pinho-Oliveira, José Pedro Assunção
OBJECTIVE: We present a series of 3 cases in which the impact in outcome was, first of all, related to the capacity to offer early and safer treatment to some hip fracture high-risk patients using a fascia iliaca block (FIB; ropivacaine 0,5% 20 cc and mepivacaine 1,3% 15 cc, given 30 minutes before incision) associated only with deep sedation, contributing to better practice and outcome. CASE REPORTS: All elderly patients were American Society of Anesthesiologists IV patients, under P2Y12 receptor inhibitors, suffering from an intertrochanteric fracture, and purposed for intramedullary femoral fixation (IMF)...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27816166/-perineural-dexmedetomidine-effects-on-sciatic-nerve-in-rat
#5
Abdulkadir Yektaş, Murat Çabalar, Mehmet Sar, Ayşin Alagöl, Duygu Sultan Çelik, Vildan Yayla, Deniz Tolga
The present study was designed to test the hypothesis that high dose dexmedetomidine would increase the duration of antinociception to a thermal stimulus in a rat model of sciatic nerve blockade without causing nerve damage. The rats were anesthetized with isoflurane. After electromyography (EMG) recordings, right sciatic nerves were explored and perineural injections were delivered: Group D (n=7), 40μgμgkg(-1) dexmedetomidine administration, Group II (n=6), (0.2mL) saline administration, Group III (n=2), only surgically exploration of the right sciatic nevre...
November 2, 2016: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/27810208/retrograde-maxillary-nerve-perineural-injection-a-tomographic-and-anatomical-evaluation-of-the-infraorbital-canal-and-evaluation-of-needle-type-and-size-in-equine-cadavers
#6
S Nannarone, G Bini, M Vuerich, L Menchetti, R Arcelli, G Angeli
The aim of this study was to investigate a new approach for equine maxillary nerve blocks, which can facilitate several orofacial surgeries. Current techniques aim at the maxillary foramen and approach via the zygomatic arch, conferring the risk of injury to several delicate structures in the target area. To investigate the feasibility of a retrograde approach from the infraorbital foramen, an anatomic study of the infraorbital canal and its surrounding structures was performed on 13 cadaveric skulls using computed tomography and anatomical dissection...
November 2016: Veterinary Journal
https://www.readbyqxmd.com/read/27749351/optimizing-pain-and-rehabilitation-after-knee-arthroplasty-a-two-center-randomized-trial
#7
Stephen Choi, Turlough O'Hare, Jeffrey Gollish, James E Paul, Hans Kreder, Kevin E Thorpe, Joel D Katz, Muhammad Mamdani, Peter Moisiuk, Colin J McCartney
BACKGROUND: This randomized trial compared (1) continuous femoral nerve block (cFNB), (2) single femoral nerve block (sFNB), and (3) local infiltration analgesia (LIA) with respect to analgesic and functional outcomes after primary tricompartmental knee arthroplasty (TKA). METHODS: One hundred twenty patients undergoing primary tricompartmental knee arthroplasty were randomly assigned to 1 of 3 interventions for postoperative analgesia: (1) cFNB-preoperative bolus of ropivacaine 0...
November 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27717401/adoptive-transfer-of-m2-macrophages-reduces-neuropathic-pain-via-opioid-peptides
#8
Maria Pannell, Dominika Labuz, Melih Ö Celik, Jacqueline Keye, Arvind Batra, Britta Siegmund, Halina Machelska
BACKGROUND: During the inflammation which occurs following nerve damage, macrophages are recruited to the site of injury. Phenotypic diversity is a hallmark of the macrophage lineage and includes pro-inflammatory M1 and anti-inflammatory M2 populations. Our aim in this study was to investigate the ability of polarized M0, M1, and M2 macrophages to secrete opioid peptides and to examine their relative contribution to the modulation of neuropathic pain. METHODS: Mouse bone marrow-derived cells were cultured as unstimulated M0 macrophages or were stimulated into an M1 phenotype using lipopolysaccharide and interferon-γ or into an M2 phenotype using interleukin-4...
October 7, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27663451/a-randomized-comparison-between-intravenous-and-perineural-dexamethasone-for-ultrasound-guided-axillary-block
#9
Julian Aliste, Prangmalee Leurcharusmee, Phatthanaphol Engsusophon, Aida Gordon, Giuliano Michelagnoli, Chonticha Sriparkdee, Worakamol Tiyaprasertkul, Dana Q Tran, Tom C R V Van Zundert, Roderick J Finlayson, De Q H Tran
BACKGROUND: This randomized double-blinded trial compared the effect of intravenous and perineural dexamethasone (8 mg) on the duration of motor block for ultrasound (US)-guided axillary brachial plexus block (AXB). METHODS: Patients undergoing upper limb surgery with US-guided AXB were randomly allocated to receive preservative-free dexamethasone (8 mg) via intravenous (n = 75) or perineural (n = 75) administration. The local anesthetic agent, 1% lidocaine -0...
September 23, 2016: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/27650364/comparison-of-histopathological-effects-of-perineural-administration-of-bupivacaine-and-bupivacaine-dexmedetomidine-in-rat-sciatic-nerve
#10
Elham Memari, Mohammad-Ali Hosseinian, Ali Mirkheshti, Ali Arhami-Dolatabadi, Mojtaba Mirabotalebi, Mohsen Khandaghy, Yahya Daneshbod, Leila Alizadeh, Sadegh Shirian
Injection of a variety of drugs such as local anesthetics (LAs) for peripheral nerve block has been shown to cause damage to peripheral nerves. Bupivacaine is a local anesthetic widely used in surgical procedures. The aim of this study was to evaluate the neurotoxicity of LAs including Bupivacaine and dexmedetomidine (DEX)-Bupivacaine on sciatic nerve tissue at histopathological level. In addition, we investigated whether perineural administration of DEX can attenuate Bupivacaine-induced neurotoxicity. Twenty adult Sprague Dawley rats received unilateral sciatic nerve blocks with either 0...
September 17, 2016: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/27618322/ct-guided-perineural-injections-for-chronic-pelvic-pain
#11
Vibhor Wadhwa, Kelly M Scott, Shai Rozen, Adam J Starr, Avneesh Chhabra
Chronic pelvic pain is a disabling condition that affects a large number of men and women. It may occur after a known inciting event, or it could be idiopathic. A common cause of pelvic pain syndrome is neuropathy of the pelvic nerves, including the femoral and genitofemoral nerves, ilioinguinal and iliohypogastric nerves, pudendal nerve, obturator nerve, lateral and posterior femoral cutaneous nerves, inferior cluneal nerves, inferior rectal nerve, sciatic nerve, superior gluteal nerve, and the spinal nerve roots...
September 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27568492/perineural-bupivacaine-injection-reduces-inguinodynia-after-inguinal-hernia-repair
#12
Joseph G Crompton, Aaron J Dawes, Graham W Donald, Masha J Livhits, Charles F Chandler
BACKGROUND: Inguinodynia, defined as pain lasting >3 months after inguinal hernia repair, remains the major complication of hernia operation. We sought to determine the effect of direct perineural infiltration on acute pain and inguinodynia after open inguinal hernia repair. METHODS: Patients who presented with an inguinal hernia at a university teaching hospital were evaluated prospectively and randomized to either (1) percutaneous ilioinguinal nerve block or (2) percutaneous ilioinguinal nerve block with additional perineural infiltration of the ilioinguinal, iliohypogastric, genitofemoral nerves...
December 2016: Surgery
https://www.readbyqxmd.com/read/27563364/lower-extremity-near-infrared-spectroscopy-after-popliteal-block-for-orthopaedic-foot-surgery
#13
Stijn Van de Velde, Alain F Kalmar, Matthias Raes, Jan Poelaert, Tom Lootens, Henk Vanoverschelde
BACKGROUND: Noninvasive measurement of cutaneous tissue oxygenation using near-infrared spectroscopy (NIRS) has become common in peri-operative care. Following institution of peripheral nerve blocks, neurovascular alterations in the blocked region have been described. OBJECTIVE: The primary aim of this study encompassed the assessment of the influence of a popliteal block on changes in regional oxygen saturation (SrO2), and the location of most prominent changes...
2016: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/27559966/minimum-effective-local-anesthetic-volume-for-surgical-anesthesia-by-subparaneural-ultrasound-guided-popliteal-sciatic-nerve-block-a-prospective-dose-finding-study
#14
Seung Uk Bang, Dong Ju Kim, Jin Ho Bae, Kyudon Chung, Yeesuk Kim
Because of its rapid onset time, recent years have seen an increase in the use of ultrasound (US)-guided popliteal sciatic nerve block (PSNB) via subparaneural injection for induction of surgical anesthesia. Moreover, in below-knee surgery, combined blocks, as opposed to sciatic nerve block alone, have become more common. These combined blocks often require a large volume of local anesthetic (LA), thus increasing the risk of local-anesthetic systemic toxicity (LAST). Thus, to decrease the risk of LAST, it is important to know the minimum effective volume (MEV) required for an adequate block...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27473629/the-combination-of-iv-and-perineural-dexamethasone-prolongs-the-analgesic-duration-of-intercostal-nerve-blocks-compared-with-iv-dexamethasone-alone
#15
Dermot P Maher, Derek Serna-Gallegos, Rodney Mardirosian, Otto J Thomas, Xiao Zhang, Robert McKenna, Roya Yumul, Vida Zhang
OBJECTIVE:  The use of multiple-level, single-injection intercostal nerve blocks for pain control following video-assisted thorascopic surgery (VATS) is limited by the analgesic duration of local anesthetics. This study examines whether the combination of perineural and intravenous (IV) dexamethasone will prolong the duration of intraoperatively placed intercostal nerve blocks following VATS compared with IV dexamethasone and a perineural saline placebo. DESIGN:  Prospective, double-blind, randomized placebo-controlled trial...
July 29, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/27413480/presentation-of-neurolytic-effect-of-10-lidocaine-after-perineural-ultrasound-guided-injection-of-a-canine-sciatic-nerve-a-pilot-study
#16
David D Kim, Asma Asif, Sandeep Kataria
BACKGROUND: Phenol and alcohol have been used to ablate nerves to treat pain but are not specific for nerves and can damage surrounding soft tissue. Lidocaine at concentrations > 8% injected intrathecal in the animal model has been shown to be neurotoxic. Tests the hypothesis that 10% lidocaine is neurolytic after a peri-neural blockade in an ex vivo experiment on the canine sciatic nerve. METHODS: Under ultrasound, one canine sciatic nerve was injected peri-neurally with 10 cc saline and another with 10 cc of 10% lidocaine...
July 2016: Korean Journal of Pain
https://www.readbyqxmd.com/read/27387735/mechanical-nociceptive-thresholds-of-dorsal-laminae-in-horses-after-local-anaesthesia-of-the-palmar-digital-nerves-or-dorsal-branches-of-the-digital-nerve
#17
C F R Paz, J F Magalhães, H M F Mendes, SdS Rocha Junior, J K Belknap, G E S Alves, R R Faleiros
We examined the hypothesis that the palmar digital nerves (PDNs), but not the dorsal branches (DBs) of the digital nerves, innervate the sensitive dorsal laminae of the equine foot by evaluating the effects of perineural anaesthesia of the PDNs and DBs separately on pain sensation evoked via mechanical stimulation of the dorsal laminae and other regions of the equine foot. Six clinically normal mares were used in a crossover design. A portable dynamometer was used to evaluate mechanical nociceptive thresholds at different points on the dorsal laminae, bulbs of the heel, coronary band and sole before and after the horses underwent perineural injection of PDNs or DBs with a local anaesthetic solution (treated group) or an isotonic saline solution (control group)...
August 2016: Veterinary Journal
https://www.readbyqxmd.com/read/27334885/study-protocol-for-a-pilot-randomised-double-blinded-placebo-controlled-trial-of-perineural-local-anaesthetics-and-steroids-for-chronic-post-traumatic-neuropathic-pain-in-the-ankle-and-foot-the-preplans-study
#18
Anuj Bhatia, Vera Bril, Richard T Brull, Anthony Perruccio, Duminda Wijeysundera, Sabbeh Alvi, Johnny Lau, Rajiv Gandhi, Nizar Mahomed, Aileen M Davis
INTRODUCTION: Peripheral neuropathic pain (PNP) associated with trauma is often refractory to treatment. Administration of local anaesthetics (LA) and steroids around injured nerves has been proposed as an option for patients unresponsive to conventional treatments for refractory PNP following trauma. There is insufficient evidence to support a large, potentially expensive, full-scale randomised controlled trial (RCT) that involves comparison of effects of perineural steroids and LA against LA or saline injections on analgesia, physical and psychological functioning, and quality of life...
June 22, 2016: BMJ Open
https://www.readbyqxmd.com/read/27322898/chronic-cancer-related-pain-continuous-perineural-infusion-of-local-anesthetics-as-alternative-to-systemic-analgesic-drugs
#19
Regis Fuzier, Philippe Izard, Claire Cabos, Brigitte Chaminade, Jacques Pouymayou
Pain is a major concern for patients suffering from cancer. Although opioid drugs remain the gold standard for treatment of pain, little is known about the interest of continuous analgesia techniques as alternative. The aim of the present article is to detail the feasibility and to present the diversity of continuous perineural infusion of local anesthetic. A series of five patients suffering from different cancer-related pain is presented. A continuous perineural block was proposed to patients presenting with unbearable pain in an area innervated by a plexus or a nerve despite parenteral analgesic pharmacotherapy...
September 2016: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/27281084/which-is-your-choice-for-prolonging-the-analgesic-duration-of-single-shot-interscalene-brachial-blocks-for-arthroscopic-shoulder-surgery-intravenous-dexamethasone-5%C3%A2-mg-vs-perineural-dexamethasone-5%C3%A2-mg-randomized-controlled-clinical-trial
#20
Eun Hee Chun, Youn Jin Kim, Jae Hee Woo
The aim of this study was to compare the effect of intravenous (I.V.) dexamethasone with that of perineural dexamethasone on the prolongation of analgesic duration of single-shot interscalene brachial plexus blocks (SISB) in patients undergoing arthroscopic shoulder surgery. We performed a prospective, randomized, double-blind, placebo-controlled study. Patients undergoing elective arthroscopic shoulder surgery with ultrasound-guided SISB were enrolled and randomized into 2 groups. A total volume of 12 mL of the study drug was prepared with a final concentration of 0...
June 2016: Medicine (Baltimore)
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