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https://www.readbyqxmd.com/read/27867675/a-case-of-thyroid-storm-associated-with-cardiomyopathy-and-poststreptococcal-glomerulonephritis
#1
Lisa J Underland, Gerson A Vallencia Villeda, Abhijeet Pal, Leslie Lam
Thyroid storm has a high mortality rate and is often associated with a precipitating factor such as intercurrent illness or infection. It is rare in pediatric patients. Cardiac disease in hyperthyroidism mostly manifests itself as tachycardia but more serious cardiac findings have also been described. A 5-year-old male with recent strep throat infection presented with dilated cardiomyopathy, hematuria, and symptoms and lab findings consistent with severe hyperthyroidism. He was diagnosed with thyroid storm secondary to concurrent Graves' disease and poststreptococcal glomerulonephritis (PSGN)...
2016: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/27493985/a-study-to-determine-if-addition-of-palatal-petechiae-to-centor-criteria-adds-more-significance-to-clinical-diagnosis-of-acute-strep-pharyngitis-in-children
#2
Kumara V Nibhanipudi
Objective. A study to determine if addition of palatal petechiae to Centor criteria adds more value for clinical diagnosis of acute strep pharyngitis in children. Hypothesis. In children, Centor Criteria does not cover all the symptoms and signs of acute strep pharyngitis. We hypothesize that addition of palatal petechiae to Centor Criteria will increase the possibility of clinical diagnosis of group A streptococcal pharyngitis in children. Methods. One hundred patients with a complaint of sore throat were enrolled in the study...
2016: Global Pediatric Health
https://www.readbyqxmd.com/read/27386730/strep-throat
#3
(no author information available yet)
No abstract text is available yet for this article.
July 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27374000/rapid-antigen-detection-test-for-group-a-streptococcus-in-children-with-pharyngitis
#4
REVIEW
Jérémie F Cohen, Nathalie Bertille, Robert Cohen, Martin Chalumeau
BACKGROUND: Group A streptococcus (GAS) accounts for 20% to 40% of cases of pharyngitis in children; the remaining cases are caused by viruses. Compared with throat culture, rapid antigen detection tests (RADTs) offer diagnosis at the point of care (within five to 10 minutes). OBJECTIVES: To determine the diagnostic accuracy of RADTs for diagnosing GAS in children with pharyngitis. To assess the relative diagnostic accuracy of the two major types of RADTs (enzyme immunoassays (EIA) and optical immunoassays (OIA)) by indirect and direct comparison...
July 4, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27313096/who-really-gets-strep-sore-throat-confounding-and-effect-modification-of-a-time-varying-exposure-on-recurrent-events
#5
Dean Follmann, Chiung-Yu Huang, Erin Gabriel
Unmeasured confounding is the fundamental obstacle to drawing causal conclusions about the impact of an intervention from observational data. Typically, covariates are measured to eliminate or ameliorate confounding, but they may be insufficient or unavailable. In the special setting where a transient intervention or exposure varies over time within each individual and confounding is time constant, a different tack is possible. The key idea is to condition on either the overall outcome or the proportion of time in the intervention...
October 30, 2016: Statistics in Medicine
https://www.readbyqxmd.com/read/27312939/streptococcus-pyogenes-adhesion-and-colonization
#6
REVIEW
Stephan Brouwer, Timothy C Barnett, Tania Rivera-Hernandez, Manfred Rohde, Mark J Walker
Streptococcus pyogenes (group A Streptococcus, GAS) is a human-adapted pathogen responsible for a wide spectrum of disease. GAS can cause relatively mild illnesses, such as strep throat or impetigo, and less frequent but severe life-threatening diseases such as necrotizing fasciitis and streptococcal toxic shock syndrome. GAS is an important public health problem causing significant morbidity and mortality worldwide. The main route of GAS transmission between humans is through close or direct physical contact, and particularly via respiratory droplets...
November 2016: FEBS Letters
https://www.readbyqxmd.com/read/27170794/use-of-point-of-care-tests-pocts-by-us-primary-care-physicians
#7
Augustine J Sohn, John M Hickner, Fasika Alem
OBJECTIVE: Point-of-care testing (POCT) has been used in the United States for several decades to diagnose and monitor acute and chronic medical conditions. The aim of this study is to assess the use of POCT and perceived benefits of and concerns regarding POCT among US family physicians. METHODS: A total of 405 US family physicians responded to an electronic survey about their use of POCT for diagnosing and monitoring illnesses and for reducing referrals for specialty care...
May 2016: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/26934845/point-of-care-testing-for-group-a-streptococci-in-patients-presenting-with-pharyngitis-will-improve-appropriate-antibiotic-prescription
#8
Ulrich Orda, Biswadev Mitra, Sabine Orda, Mark Fitzgerald, Ronny Gunnarsson, Geoff Rofe, Anna Dargan
OBJECTIVE: History, clinical examination and throat culture may be inadequate to rule in or out the presence of group A streptococci (GAS) infection in patients with sore throat in a remote location. We correlated the diagnostic accuracy for guiding antibiotic prescription of clinical decision and physiological scoring systems to a rapid diagnostic point of care (POC) test result in paediatric patients presenting with sore throat. METHODS: Prospective diagnostic accuracy study conducted between 30 June 2014 and 27 February 2015 in a remote Australian ED using a convenience sample...
April 2016: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/26873279/etiologic-predictive-value-of-a-rapid-immunoassay-for-the-detection-of-group-a-streptococcus-antigen-from-throat-swabs-in-patients-presenting-with-a-sore-throat
#9
Ulrich Orda, Ronny Gunnarsson, Sabine Orda, Mark Fitzgerald, Geoff Rofe, Anna Dargan
BACKGROUND: Clinical reasoning utilizing certain symptoms and scores has not proven to be a reliable decision-making tool to determine whether or not to suspect a group A Streptococcus (GAS) infection in the patient presenting with a sore throat. Culture as the so-called 'gold standard' is impracticable because it takes 1 to 2 days (and even longer in remote locations) for a result, and thus treatment decisions will be made without the result available. Rapid diagnostic antigen tests have demonstrated sufficient sensitivities and specificities in detecting GAS antigens to identify GAS throat infections...
April 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/26687497/clinical-signs-and-diagnostic-tests-in-acute-respiratory-infections
#10
Raziye Dut, Sesin Kocagöz
OBJECTIVES: To evaluate clinical manifestations of acute respiratory system infectious diseases and specific tests for causative agents in pediatric patients. METHODS: The authors evaluated children aged 0-16 y with clinical symptoms of acute respiratory tract infections who were administered rapid strep A test and/or throat culture test and/or respiratory viral panel test, from February 2012 through January 2013 at pediatric department of Acıbadem Maslak Hospital, Turkey...
May 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/26679835/the-simplexa%C3%A2-group-a-strep-direct-assay-a-sample-to-answer-molecular-assay-for-the-diagnosis-of-group-a-streptococcal-pharyngitis
#11
Michelle M Tabb, Hollis J Batterman
The Simplexa™ Group A Strep Direct assay is intended for use on the Integrated Cycler for detection of Group A Streptococcus (GAS) directly from throat swabs that have not undergone nucleic acid extraction. A prospective study of 1352 samples in 4 geographically diverse sites showed an overall prevalence of GAS of 15.4%. The assay demonstrated 97.4% sensitivity and 95.2% specificity versus culture. The positive predictive value compared to culture was 72.7%. However, 46 out of 57 discrepant samples were Group A Strep positive when tested using a bi-directional sequencing method illustrating the increased sensitivity of the assay compared to culture for detection of GAS...
2016: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/26443457/trading-capsule-for-increased-cytotoxin-production-contribution-to-virulence-of-a-newly-emerged-clade-of-emm89-streptococcus-pyogenes
#12
Luchang Zhu, Randall J Olsen, Waleed Nasser, Ivan de la Riva Morales, James M Musser
UNLABELLED: Strains of emm89 Streptococcus pyogenes have become one of the major causes of invasive infections worldwide in the last 10 years. We recently sequenced the genome of 1,125 emm89 strains and identified three major phylogenetic groups, designated clade 1, clade 2, and the epidemic clade 3. Epidemic clade 3 strains, which now cause the great majority of infections, have two distinct genetic features compared to clade 1 and clade 2 strains. First, all clade 3 organisms have a variant 3 nga promoter region pattern, which is associated with increased production of secreted cytolytic toxins SPN (S...
2015: MBio
https://www.readbyqxmd.com/read/26427925/taking-chances-with-strep-throat
#13
Katherine McMurray, Matthew Garber
No abstract text is available yet for this article.
October 2015: Hospital Pediatrics
https://www.readbyqxmd.com/read/26385939/streptococcal-pharyngitis-an-uncommon-cause-of-subdural-empyema
#14
Jeffrey Howard Walden, Bryan Hess, Michael Rigby
A 7-year-old girl with an unremarkable medical history presented to a local paediatric emergency department with a 7-day history of fever, sore throat and vomiting, and a 1-day history of rash. She was admitted to the hospital, with presumed Kawasaki disease. A few hours after admission, the patient had sudden onset of two witnessed tonic-clonic seizures and subsequent decreased mental status. She was transferred to the paediatric intensive care unit and started on broad-spectrum antibiotics. On hospital day 2, cerebral spinal fluid cultures and blood cultures grew Streptococcus pyogenes, and repeat physical examination was consistent with acute streptococcal pharyngitis...
2015: BMJ Case Reports
https://www.readbyqxmd.com/read/26313273/-carriage-of-streptococcus-pyogenes-in-primary-school-children-m-protein-types-pyrogenic-toxin-genes-and-investigation-of-the-clonal-relationships-between-the-isolates
#15
Barış Otlu, Cemşit Karakurt, Yaşar Bayındır, Üner Kayabaş, Yusuf Yakupoğulları, Harika Gözükara Bağ
M-protein and pyrogenic toxins are the most important virulence factors of Streptococcus pyogenes, and they play significant role in the pathophysiology of acute rheumatoid fever and scarlet fever, respectively. In this study, the pharyngeal carriage of S.pyogenes of the primary school children, clonal relationship of the strains, M-protein types, and the presence of pyrogenic toxin genes were aimed to be investigated. A total of 668 throat cultures obtained from children (age range: 6-16 years) in two primary schools in our region, were included in the study...
July 2015: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/26310266/puerperal-sepsis-in-the-21st-century-progress-new-challenges-and-the-situation-worldwide
#16
REVIEW
Bigna S Buddeberg, Wynne Aveling
Puerperal sepsis is one of the five leading causes of maternal mortality worldwide, and accounts for 15% of all maternal deaths. The WHO defined puerperal sepsis in 1992 as an infection of the genital tract occurring at any time between the rupture of membranes or labour and the 42nd day post partum; in which, two or more of the following are present: pelvic pain, fever, abnormal vaginal discharge and delay in the reduction of the size of the uterus. At the same time, the WHO introduced the term puerperal infections, which also include non-genital infections in the obstetric population...
October 2015: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/26295745/a-reappraisal-of-the-minimum-duration-of-antibiotic-treatment-before-approval-of-return-to-school-for-children-with-streptococcal-pharyngitis
#17
Richard H Schwartz, Danica Kim, Michael Martin, Michael E Pichichero
OBJECTIVE: To determine whether a single dose of amoxicillin administered to a symptomatic child with confirmed strep throat might allow the child to return to school as little as 12 hours later. METHODS: We enrolled 111 evaluable children with sore throat plus a positive streptococcal rapid antigen detection test (RADT) as well as a positive result for group A Streptococci (GAS). After throat swab specimens were obtained, all participants received a single dose of amoxicillin (50 mg/kg)...
December 2015: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/26261387/representation-of-streptococcus-pneumoniae-in-outpatient-population-of-sarajevo-canton
#18
Mufida Aljicevic, Emina Karcic, Sabaheta Bektas, Bekir Karcic
INTRODUCTION: Streptococcus pneumoniae in asymptomatic manner colonize the mucous membranes of the nasopharynx of children and adults, but can cause serious illness in the media which are naturally sterile. In 5-40% of healthy population this bacteria colonize the nasopharyngeal mucosa thanks to the surface adhesin protein, which allow the bacteria to attach to the epithelial cells. The normal nasopharyngeal microflora retains pneumococcus in a small number and does not allow it to express its pathogenic potential and cause disease...
June 2015: Medical Archives
https://www.readbyqxmd.com/read/26243278/streptococcus-pyogenes-strains-in-sao-paulo-brazil-molecular-characterization-as-a-basis-for-streptincor-coverage-capacity-analysis
#19
Samar Freschi de Barros, Karine Marafigo De Amicis, Raquel Alencar, Pierre Robert Smeesters, Ariel Trunkel, Edilberto Postól, João Nóbrega Almeida Junior, Flavia Rossi, Antonio Carlos Campos Pignatari, Jorge Kalil, Luiza Guilherme
BACKGROUND: Several human diseases are caused by Streptococcus pyogenes, ranging from common infections to autoimmunity. Characterization of the most prevalent strains worldwide is a useful tool for evaluating the coverage capacity of vaccines under development. In this study, a collection of S. pyogenes strains from Sao Paulo, Brazil, was analyzed to describe the diversity of strains and assess the vaccine coverage capacity of StreptInCor. METHODS: Molecular epidemiology of S...
2015: BMC Infectious Diseases
https://www.readbyqxmd.com/read/26216315/ambient-ozone-and-bacterium-streptococcus-a-link-between-cellulitis-and-pharyngitis
#20
Giuseppe Valacchi, Eugeniusz Porada, Brian H Rowe
OBJECTIVES: Ambient air pollution, as many publications indicate, may have associations with skin condition. The aim of this study has been to examine such common relations for cellulitis and pharyngitis. The hypothesis is that ambient ground-level ozone may help bacteria to penetrate skin or throat. MATERIAL AND METHODS: We used the emergency department (ED) visits data in Edmonton, Canada for the period from 1992 (April) to 2002 (March). We retrieved all the diagnosed ED visits for cellulitis and pharyngitis...
2015: International Journal of Occupational Medicine and Environmental Health
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