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https://www.readbyqxmd.com/read/28912884/towards-translational-immunopet-mr-imaging-of-invasive-pulmonary-aspergillosis-the-humanised-monoclonal-antibody-jf5-detects-aspergillus-lung-infections-in-vivo
#1
Genna Davies, Anna-Maria Rolle, Andreas Maurer, Philipp R Spycher, Claudia Schillinger, Djamschid Solouk-Saran, Mike Hasenberg, Juliane Weski, Jesper Fonslet, Adrien Dubois, Frederic Boschetti, Franck Denat, Matthias Gunzer, Martin Eichner, Lauren S Ryder, Mikael Jensen, Roger Schibli, Bernd J Pichler, Stefan Wiehr, Christopher R Thornton
Invasive pulmonary aspergillosis (IPA) is a life-threatening lung disease of hematological malignancy or bone marrow transplant patients caused by the ubiquitous environmental fungus Aspergillus fumigatus. Current diagnostic tests for the disease lack sensitivity as well as specificity, and culture of the fungus from invasive lung biopsy, considered the gold standard for IPA detection, is slow and often not possible in critically ill patients. In a previous study, we reported the development of a novel non-invasive procedure for IPA diagnosis based on antibody-guided positron emission tomography and magnetic resonance imaging (immunoPET/MRI) using a [(64)Cu]DOTA-labeled mouse monoclonal antibody (mAb), mJF5, specific to Aspergillus...
2017: Theranostics
https://www.readbyqxmd.com/read/28911972/sex-specific-effects-of-developmental-lead-exposure-on-the-immune-neuroendocrine-network
#2
REVIEW
Jane Kasten-Jolly, David A Lawrence
The environmental toxicant lead (Pb) has long been known to induce neurological deficits. The 1st century Greek physician Pedanius Dioscorides noted that "lead makes the mind give way". Current studies are suggesting the effects of Pb on behaviors may involve the immune system and conversely some immunomodulatory changes may be due to Pb effects in the central nervous system. Although Pb-induced disorders do not appear to discriminate among females and males, this report discusses the differences observed in human and animal studies regarding differential gender effects on gene expression after Pb exposure...
September 11, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28910548/time-of-day-effects-of-exposure-to-solar-radiation-on-thermoregulation-during-outdoor-exercise-in-the-heat
#3
Hidenori Otani, Takayuki Goto, Heita Goto, Minayuki Shirato
High solar radiation has been recognised as a contributing factor to exertional heat-related illness in individuals exercising outdoors in the heat. Although solar radiation intensity has been known to have similar time-of-day variation as body temperature, the relationship between fluctuations in solar radiation associated with diurnal change in the angle of sunlight and thermoregulatory responses in individuals exercising outdoors in a hot environment remains largely unknown. The present study therefore investigated the time-of-day effects of variations in solar radiation associated with changing solar elevation angle on thermoregulatory responses during moderate-intensity outdoor exercise in the heat of summer...
September 14, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28900363/concerning-the-vitamin-d-reference-range-pre-analytical-and-analytical-variability-of-vitamin-d-measurement
#4
REVIEW
Davide Ferrari, Giovanni Lombardi, Giuseppe Banfi
Unlike other vitamins, the vitamin D concentration in blood varies cyclically over the course of the year in relation to genetic (gender, ethnicity, polymorphisms) and environmental factors (sunlight exposure, diet, food-related or direct vitamin D supplementation, skin pigmentation). Although the major diagnostics manufacturers have recently developed improved automated 25-hydroxy vitamin D immunoassays, the intra- and inter-laboratory variability is still high (especially at low vitamin D concentrations) which might lead to incorrect vitamin D deficiency/insufficiency diagnosis...
October 15, 2017: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/28895427/the-impact-of-self-perceived-limitations-stigma-and-sense-of-coherence-on-quality-of-life-in-multiple-sclerosis-patients-results-of-a-cross-sectional-study
#5
Feddrik Broersma, Barth Oeseburg, Jacob Dijkstra, Klaske Wynia
OBJECTIVE: To examine the impact of perceived limitations, stigma and sense of coherence on quality of life in multiple sclerosis patients. DESIGN: Cross-sectional survey. SETTING: Department of Neurology, University Medical Center Groningen, the Netherlands. SUBJECTS: Multiple sclerosis patients. MAIN MEASURES: World Health Organization Quality of Life - abbreviated version, Stigma Scale for Chronic Illness, Sense of Coherence Scale, background and disease-related questions...
September 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28891019/uncivilizing-mental-illness-contextualizing-diverse-mental-states-and-posthuman-emotional-ecologies-within-the-icarus-project
#6
Erica Hua Fletcher
This article argues humans should not be defined strictly at their physical boundaries with clear distinctions between anatomical bodies, mental states, and the rest of the world. Rather, diverse mental states, which are often diagnosed as "mental illness," take shape within greater environmental forces and flows, including those that are constructed online. Drawing from a multi-sited ethnography of The Icarus Project, a radical mental health community, the author situates online narratives written by two of its members within posthuman emotional ecologies in which the exchange of ideas online affects mental states in a profound way...
September 11, 2017: Journal of Medical Humanities
https://www.readbyqxmd.com/read/28890593/examples-of-applied-public-health-through-the-work-of-the-epidemic-intelligence-service-officers-at-cdc-s-national-center-for-environmental-health-2006-2015
#7
Yulia I Carroll, Fauzia A Rashid, Henry Falk, Meredith M Howley
The Epidemic Intelligence Service officers (EISOs) at the National Center for Environmental Health (NCEH)/Agency for Toxic Substances and Disease Registry (ATSDR) respond to public health outbreaks, assist public health surveillance, and recommend public health actions. We summarize the breadth of work done by EISOs assigned to NCEH/ATSDR during 2006-2015. We used the Web of Science, Scopus, and PubMed databases to identify articles authored by the EISOs, number and types of epidemiologic assistance field investigations (Epi-Aids), and interviewed NCEH/ATSDR programs with EISO assignees...
2017: Public Health Reviews
https://www.readbyqxmd.com/read/28888127/environmental-injustice-and-sexual-minority-health-disparities-a%C3%A2-national-study-of-inequitable-health-risks-from-air-pollution-among-same-sex-partners
#8
Timothy W Collins, Sara E Grineski, Danielle X Morales
Air pollution is deleterious to human health, and numerous studies have documented racial and socioeconomic inequities in air pollution exposures. Despite the marginalized status of lesbian, gay, bisexual, and transgender (LGBT) populations, no national studies have examined if they experience inequitable exposures to air pollution. This cross-sectional study investigated inequities in the exposure of same-sex partner households to hazardous air pollutants (HAPs) in the US. We examined cancer and respiratory risks from HAPs across 71,207 census tracts using National Air Toxics Assessment and US Census data...
September 6, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28887647/a-comparative-evaluation-study-of-growth-conditions-for-culturing-the-isolates-of-campylobacter-spp
#9
Ying-Hsin Hsieh, Steven Simpson, Khalil Kerdahi, Irshad M Sulaiman
Campylobacter is one of the leading causes of foodborne travelers' diarrhea worldwide. Although a large number cases of campylobacteriosis go undiagnosed or unreported, it is considered as the second most common foodborne illness in the USA affecting over 1.3 million individuals every year. Of various Campylobacter species, C. jejuni, C. coli, and C. lari have been accounted for causing more than 99% of human infections. Thus, there is a need to have efficient isolation method to protect public health on food safety and monitoring the burden of campylobacteriosis...
September 8, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28880010/chronic-pancreatitis
#10
REVIEW
Jorg Kleeff, David C Whitcomb, Tooru Shimosegawa, Irene Esposito, Markus M Lerch, Thomas Gress, Julia Mayerle, Asbjørn Mohr Drewes, Vinciane Rebours, Fatih Akisik, J Enrique Domínguez Muñoz, John P Neoptolemos
Chronic pancreatitis is defined as a pathological fibro-inflammatory syndrome of the pancreas in individuals with genetic, environmental and/or other risk factors who develop persistent pathological responses to parenchymal injury or stress. Potential causes can include toxic factors (such as alcohol or smoking), metabolic abnormalities, idiopathic mechanisms, genetics, autoimmune responses and obstructive mechanisms. The pathophysiology of chronic pancreatitis is fairly complex and includes acinar cell injury, acinar stress responses, duct dysfunction, persistent or altered inflammation, and/or neuro-immune crosstalk, but these mechanisms are not completely understood...
September 7, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28878696/-i-am-i-and-my-bacterial-circumstances-linking-gut-microbiome-neurodevelopment-and-depression
#11
REVIEW
Juan M Lima-Ojeda, Rainer Rupprecht, Thomas C Baghai
Recently, there has been renewed interest in the role played by microbiome in both human health and human disease. A correct equilibrium between the human host and their microorganisms is important for an appropriate physiological function. Extensive research has shown that microbes that inhabit the gastrointestinal tract-or gut microbiota-are involved not only in both nutritive and digestive activities but also in immunological processes. Moreover, the gut microbiome influences both central nervous system and energy homeostasis...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28865447/multicenter-assessment-of-sedation-and-delirium-practices-in-the-intensive-care-units-in-poland-is-this-common-practice-in-eastern-europe
#12
Katarzyna Kotfis, Małgorzata Zegan-Barańska, Maciej Żukowski, Krzysztof Kusza, Mariusz Kaczmarczyk, E Wesley Ely
BACKGROUND: The majority of critically ill patients experience distress during their stay in the Intensive Care Unit (ICU), resulting from systemic illness, multiple interventions and environmental factors. Providing humane care should address concomitant treatment of pain, agitation and delirium. The use of sedation and approaches to ICU delirium should be monitored according to structured guidelines. However, it is unknown to what extent these concepts are followed in Eastern European countries like Poland...
September 2, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28865264/the-association-between-environmental-lead-exposure-with-aggressive-behavior-and-dimensionality-of-direct-and-indirect-aggression-during-mid-adolescence-birth-to-twenty-plus-cohort
#13
Palesa Nkomo, Nisha Naicker, Angela Mathee, Jacky Galpin, Linda M Richter, Shane A Norris
Chronic lead exposure is associated with neurological ill-health including anti-social behavior such as aggressive behavior. The main aim of this study was to examine the association between lead exposure at 13years old and dimensions of aggressive behavior during mid-adolescence. The study sample included 508 males and 578 females in mid-adolescence (age 14 to 15years) from the Birth to Twenty Plus cohort in Johannesburg, South Africa. Blood samples collected at age 13years were used to measure blood lead levels...
August 30, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28864657/recovery-optimization-and-survival-of-human-norovirus-surrogates-feline-calicivirus-and-murine-norovirus-on-carpet
#14
David Buckley, Angela Fraser, Guohui Huang, Xiuping Jiang
Carpet been attributed to prolonged and reoccurring outbreaks of human noroviruses (HuNoV), the leading cause of acute gastroenteritis worldwide. Viral recovery from environmental surfaces, such as carpet, remains undeveloped. Our aim was to determine survival of HuNoV surrogates on an understudied environmental surface, carpet. First, we measured the zeta potential and absorption capacity of wool and nylon carpet fibers, then developed a mini-spin column elution method (MSC), and lastly characterized the survival of HuNoV surrogates, feline calicivirus (FCV) and murine norovirus (MNV), over 60 days under 30 and 70% relative humidity (RH) on two types of carpet and one glass surface...
September 1, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28861904/equity-trade-offs-in-conservation-decision-making
#15
Elizabeth A Law, Nathan J Bennett, Christopher D Ives, Rachel Friedman, Katrina J Davis, Carla Archibald, Kerrie A Wilson
Conservation decisions increasingly involve multiple environmental and social objectives, which result in complex decision contexts with high potential for trade-offs. Improving social equity is one such objective that is often considered an enabler of successful outcomes and a virtuous ideal in itself. Despite its idealized importance in conservation policy, social equity is often highly simplified or ill-defined and is applied uncritically. What constitutes equitable outcomes and processes is highly normative and subject to ethical deliberation...
September 1, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28861745/promising-practices-for-making-recreation-programming-matter-for-people-who-experience-mental-illness
#16
Susan L Hutchinson, Lara Fenton
There is merit in understanding how recreation-oriented programs for adults living with mental illness address barriers to participation and how programming is structured to create safe and inclusive environments, resulting in programming that amplifies the benefits of recreation for mental well-being. Following an environmental scan of programs targeting adults living with mental illness in Canada, ten coordinators in community mental health settings were interviewed. Four themes were constructed to reflect characteristics deemed to be 'promising practices' related to recreation-oriented programming: (a) barriers and solutions to individual participation, (b) characteristics of welcoming and supportive environments,...
August 31, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28860055/novel-and-environmental-friendly-approach-impact-of-neem-azadirachta-indica-gum-nano-formulation-ngnf-on-helicoverpa-armigera-hub-and-spodoptera-litura-fab
#17
Chinnaperumal Kamaraj, Pachiyappan Rajiv Gandhi, Gandhi Elango, Sengodan Karthi, Ill-Min Chung, Govindsamy Rajakumar
The future of this study was to prepare a natural pesticide which will not harm the environment and yet control pests. Neem gum nano formulation (NGNF), a novel biopesticide prepared from the Neem gum extract (Azadirachta indica) (NGE) was evaluated for its antifeedant, larvicidal and pupicidal activities against Helicoverpa armigera (Hub.) and Spodoptera litura (Fab.) at 100ppm. The NGNF showed significant (100%) antifeedant, larvicidal and pupicidal activities against H. armigera and S. litura. The LC50 values of 10...
August 28, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28859689/remote-sensing-measurements-of-sea-surface-temperature-as-an-indicator-of-vibrio-parahaemolyticus-in-oyster-meat-and-human-illnesses
#18
Stephanie Konrad, Peggy Paduraru, Pablo Romero-Barrios, Sarah B Henderson, Eleni Galanis
BACKGROUND: Vibrio parahaemolyticus (Vp) is a naturally occurring bacterium found in marine environments worldwide. It can cause gastrointestinal illness in humans, primarily through raw oyster consumption. Water temperatures, and potentially other environmental factors, play an important role in the growth and proliferation of Vp in the environment. Quantifying the relationships between environmental variables and indicators or incidence of Vp illness is valuable for public health surveillance to inform and enable suitable preventative measures...
August 31, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28858055/thermoregulatory-and-perceptual-effects-of-a-percooling-garment-worn-underneath-an-american-football-uniform
#19
Megan L Keen, Kevin C Miller, Micah N Zuhl
American football athletes are at the highest risk of developing exertional heat illness (EHI). We investigated whether percooling (i.e., cooling during exercise) garments affected perceptual or physiological variables in individuals exercising in the heat while wearing football uniforms. Twelve males (age=24±4y, mass=80.1±8.5kg, height=182.5±10.4cm) completed this cross-over, counterbalanced study. On day 1, we measured peak oxygen consumption (V[Combining Dot Above]O2). On days 2 and 3, participants wore percooling garments with (ICE) or without (CON) ice packs over the femoral and brachial arteries...
August 26, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28852308/influence-of-gut-microbiota-on-neuropsychiatric-disorders
#20
REVIEW
María Carmen Cenit, Yolanda Sanz, Pilar Codoñer-Franch
The last decade has witnessed a growing appreciation of the fundamental role played by an early assembly of a diverse and balanced gut microbiota and its subsequent maintenance for future health of the host. Gut microbiota is currently viewed as a key regulator of a fluent bidirectional dialogue between the gut and the brain (gut-brain axis). A number of preclinical studies have suggested that the microbiota and its genome (microbiome) may play a key role in neurodevelopmental and neurodegenerative disorders...
August 14, 2017: World Journal of Gastroenterology: WJG
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