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https://www.readbyqxmd.com/read/28692691/extracting-time-frequency-feature-of-single-channel-vastus-medialis-emg-signals-for-knee-exercise-pattern-recognition
#1
Yi Zhang, Peiyang Li, Xuyang Zhu, Steven W Su, Qing Guo, Peng Xu, Dezhong Yao
The EMG signal indicates the electrophysiological response to daily living of activities, particularly to lower-limb knee exercises. Literature reports have shown numerous benefits of the Wavelet analysis in EMG feature extraction for pattern recognition. However, its application to typical knee exercises when using only a single EMG channel is limited. In this study, three types of knee exercises, i.e., flexion of the leg up (standing), hip extension from a sitting position (sitting) and gait (walking) are investigated from 14 healthy untrained subjects, while EMG signals from the muscle group of vastus medialis and the goniometer on the knee joint of the detected leg are synchronously monitored and recorded...
2017: PloS One
https://www.readbyqxmd.com/read/28622605/flexible-nanofilms-coated-with-aligned-piezoelectric-microfibers-preserve-the-contractility-of-cardiomyocytes
#2
P José Gouveia, S Rosa, L Ricotti, B Abecasis, H V Almeida, L Monteiro, J Nunes, F Sofia Carvalho, M Serra, S Luchkin, A Leonidovitch Kholkin, P Marques Alves, P Jorge Oliveira, R Carvalho, A Menciassi, R Pires das Neves, L Silva Ferreira
The use of engineered cardiac tissue for high-throughput drug screening/toxicology assessment remains largely unexplored. Here we propose a scaffold that mimics aspects of cardiac extracellular matrix while preserving the contractility of cardiomyocytes. The scaffold is based on a poly(caprolactone) (PCL) nanofilm with magnetic properties (MNF, standing for magnetic nanofilm) coated with a layer of piezoelectric (PIEZO) microfibers of poly(vinylidene fluoride-trifluoroethylene) (MNF+PIEZO). The nanofilm creates a flexible support for cell contraction and the aligned PIEZO microfibers deposited on top of the nanofilm creates conditions for cell alignment and electrical stimulation of the seeded cells...
September 2017: Biomaterials
https://www.readbyqxmd.com/read/28505208/neuromuscular-function-of-the-quadriceps-muscle-during-isometric-maximal-submaximal-and-submaximal-fatiguing-voluntary-contractions-in-knee-osteoarthrosis-patients
#3
Anett Mau-Moeller, Robert Jacksteit, Mario Jackszis, Frank Feldhege, Matthias Weippert, Wolfram Mittelmeier, Rainer Bader, Ralf Skripitz, Martin Behrens
INTRODUCTION: Knee osteoarthrosis (KOA) is commonly associated with a dysfunction of the quadriceps muscle which contributes to alterations in motor performance. The underlying neuromuscular mechanisms of muscle dysfunction are not fully understood. The main objective of this study was to analyze how KOA affects neuromuscular function of the quadriceps muscle during different contraction intensities. MATERIALS AND METHODS: The following parameters were assessed in 20 patients and 20 healthy controls: (i) joint position sense, i...
2017: PloS One
https://www.readbyqxmd.com/read/28495590/concurrent-activation-of-%C3%AE-2-adrenergic-receptor-and-blockage-of-gpr55-disrupts-pro-oncogenic-signaling-in-glioma-cells
#4
Artur Wnorowski, Justyna Such, Rajib K Paul, Robert P Wersto, Fred E Indig, Krzysztof Jozwiak, Michel Bernier, Irving W Wainer
Activation of β2-adrenergic receptor (β2AR) and deorphanized GPR55 has been shown to modulate cancer growth in diverse tumor types in vitro and in xenograft models in vivo. (R,R')-4'-methoxy-1-naphthylfenoterol [(R,R')-MNF] is a bivalent compound that agonizes β2AR but inhibits GPR55-mediated pro-oncogenic responses. Here, we investigated the molecular mechanisms underlying the anti-tumorigenic effects of concurrent β2AR activation and GPR55 blockade in C6 glioma cells using (R,R')-MNF as a marker ligand...
August 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28484760/comparison-of-nucleophilic-and-radical-based-routes-to-the-formation-of-manganese-main-group-element-single-bonds
#5
Douglas W Agnew, Curtis E Moore, Arnold L Rheingold, Joshua S Figueroa
Using the stable metalloradical Mn(CO)3(CNAr(Dipp2))2, we report the formation of manganese-main group complexes via the single-electron functionalization of main group halides. The reactions occur in a simple 1 : 1 stoichiometry, and demonstrate the utility of using stable open-shelled organometallics as precursors for metal-main group compounds. This has enabled the preparation of manganese complexes bearing terminal -EXn substituents, as shown through the isolation of Mn(SnCl)(CO)3(CNAr(Dipp2))2 and Mn(BiCl2)(CO)3(CNAr(Dipp2))2 from SnCl2 and BiCl3, respectively...
May 9, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28448720/mosaic-neurofibromatosis-type-1-in-children-a-single-institution-experience
#6
Irene Lara-Corrales, Mitra Moazzami, Maria Teresa García-Romero, Elena Pope, Patricia Parkin, Andrea Shugar, Peter Kannu
BACKGROUND: Neurofibromatosis type 1 (NF1) is a neurocutaneous disorder caused by loss-of-function mutation in the NF1 gene. Segmental or mosaic NF1 (MNF) is an uncommon presentation of the NF1 result of postzygotic mutations that present with subtle localised clinical findings. OBJECTIVES: Our study's objectives were to describe the clinical characteristics of children with MNF. METHODS: We conducted a cross-sectional study of children diagnosed with MNF at the Hospital for Sick Children in Toronto, Canada, from January 1992 to September 2012...
April 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28289825/the-highly-bioactive-molecule-and-signal-substance-6-formylindolo-3-2-b-carbazole-ficz-plays-bi-functional-roles-in-cell-growth-and-apoptosis-in-vitro
#7
Afshin Mohammadi-Bardbori, Farzaneh Bastan, Amin-Reza Akbarizadeh
The maintenance of cellular homeostasis is a complex process that is governed by the receipt of prototypical growth and death signals. The endogenous functions of aryl hydrocarbon receptor (AHR) in cellular homeostasis are not well understood. We aimed to establish whether the disturbance of endogenously activated AHR can influence cell growth, and if so, what mechanism(s) are involved. Cell growth was measured in mouse hepatoma Hepa-1 wild-type and cytochrome P4501A1 (CYP1A1)-deficient c37 cells. In other sets of experiments, HepG2 cells were exposed to different doses of FICZ (0...
March 13, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28269457/estimation-of-muscle-fatigue-by-ratio-of-mean-frequency-to-average-rectified-value-from-surface-electromyography
#8
Jeffry Bonar Fernando, Mototaka Yoshioka, Jun Ozawa
A new method to estimate muscle fatigue quantitatively from surface electromyography (EMG) is proposed. The ratio of mean frequency (MNF) to average rectified value (ARV) is used as the index of muscle fatigue, and muscle fatigue is detected when MNF/ARV falls below a pre-determined or pre-calculated baseline. MNF/ARV gives larger distinction between fatigued muscle and non-fatigued muscle. Experiment results show the effectiveness of our method in estimating muscle fatigue more correctly compared to conventional methods...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268659/comparison-of-mean-frequency-and-median-frequency-in-evaluating-muscle-fiber-type-selection-in-varying-gait-speed-across-healthy-young-adult-individuals
#9
C K Chan, G Fu Timothy, C H Yeow
The preferential slow and fast twitches fiber involvement in varying gait speed has not been thoroughly investigated. Attempt to classify fiber type in changing speed should be closely investigated and scrutinized as the histochemical-related experiments are cumbersome and time consuming. In addressing this issue, electromyography (EMG) is utilized to extract the muscle fiber type features by altering the muscle fatigue indices, namely mean frequency (MNF) and median frequency (MDF). Recently, there are no universal indices to determine the muscle type...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227707/estimation-of-muscle-fatigue-by-ratio-of-mean-frequency-to-average-rectified-value-from-surface-electromyography
#10
Jeffry Bonar Fernando, Mototaka Yoshioka, Jun Ozawa, Jeffry Bonar Fernando, Mototaka Yoshioka, Jun Ozawa, Mototaka Yoshioka, Jeffry Bonar Fernando, Jun Ozawa
A new method to estimate muscle fatigue quantitatively from surface electromyography (EMG) is proposed. The ratio of mean frequency (MNF) to average rectified value (ARV) is used as the index of muscle fatigue, and muscle fatigue is detected when MNF/ARV falls below a pre-determined or pre-calculated baseline. MNF/ARV gives larger distinction between fatigued muscle and non-fatigued muscle. Experiment results show the effectiveness of our method in estimating muscle fatigue more correctly compared to conventional methods...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226843/comparison-of-mean-frequency-and-median-frequency-in-evaluating-muscle-fiber-type-selection-in-varying-gait-speed-across-healthy-young-adult-individuals
#11
C K Chan, G Fu Timothy, C H Yeow, C K Chan, G Fu Timothy, C H Yeow, C K Chan, C H Yeow
The preferential slow and fast twitches fiber involvement in varying gait speed has not been thoroughly investigated. Attempt to classify fiber type in changing speed should be closely investigated and scrutinized as the histochemical-related experiments are cumbersome and time consuming. In addressing this issue, electromyography (EMG) is utilized to extract the muscle fiber type features by altering the muscle fatigue indices, namely mean frequency (MNF) and median frequency (MDF). Recently, there are no universal indices to determine the muscle type...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28126654/an-explorative-chemometric-approach-applied-to-hyperspectral-images-for-the-study-of-illuminated-manuscripts
#12
Emilio Catelli, Lise Lyngsnes Randeberg, Bjørn Kåre Alsberg, Kidane Fanta Gebremariam, Silvano Bracci
Hyperspectral imaging (HSI) is a fast non-invasive imaging technology recently applied in the field of art conservation. With the help of chemometrics, important information about the spectral properties and spatial distribution of pigments can be extracted from HSI data. With the intent of expanding the applications of chemometrics to the interpretation of hyperspectral images of historical documents, and, at the same time, to study the colorants and their spatial distribution on ancient illuminated manuscripts, an explorative chemometric approach is here presented...
April 15, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28067522/development-of-a-postcolumn-infused-internal-standard-liquid-chromatography-mass-spectrometry-method-for-quantitative-metabolomics-studies
#13
Hsiao-Wei Liao, Guan-Yuan Chen, Ming-Shiang Wu, Wei-Chih Liao, Ching-Hung Lin, Ching-Hua Kuo
Quantitative metabolomics has become much more important in clinical research in recent years. Individual differences in matrix effects (MEs) and the injection order effect are two major factors that reduce the quantification accuracy in liquid chromatography-electrospray ionization-mass spectrometry-based (LC-ESI-MS) metabolomics studies. This study proposed a postcolumn infused-internal standard (PCI-IS) combined with a matrix normalization factor (MNF) strategy to improve the analytical accuracy of quantitative metabolomics...
January 19, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28040500/a-modification-of-nissen-fundoplication-improves-patients-outcome-and-may-reduce-procedure-related-failure-rate
#14
Romeo Bardini, Sabrina Rampado, Renato Salvador, Lisa Zanatta, Imerio Angriman, Silvia Degasperi, Angelica Ganss, Edoardo Savarino
BACKGROUND: Laparoscopic anti-reflux surgery has a failure rate of 10-20%. We aimed to investigate whether a modification of Nissen fundoplication (MNF) may improve patients' outcome and reduce failure rate. MATERIALS & METHODS: We prospectively compared 40 consecutive patients with gastroesophageal reflux disease who underwent anti-reflux surgery: 20 Nissen fundoplication (NF) and 20 the MNF approach. Eight cases in the MNF group needed redo surgery. The MNF consisted in suturing the esophagus to the diaphragmatic crura on each side by means of 4 non-absorbable stitches and in fixing the upper stitch of the valve to diaphragm...
February 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/27743011/variability-in-spatio-temporal-pattern-of-trapezius-activity-and-coordination-of-hand-arm-muscles-during-a-sustained-repetitive-dynamic-task
#15
Afshin Samani, Divya Srinivasan, Svend Erik Mathiassen, Pascal Madeleine
The spatio-temporal distribution of muscle activity has been suggested to be a determinant of fatigue development. Pursuing this hypothesis, we investigated the pattern of muscular activity in the shoulder and arm during a repetitive dynamic task performed until participants' rating of perceived exertion reached 8 on Borg's CR-10 scale. We collected high-density surface electromyogram (HD-EMG) over the upper trapezius, as well as bipolar EMG from biceps brachii, triceps brachii, deltoideus anterior, serratus anterior, upper and lower trapezius from 21 healthy women...
October 14, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27727120/comparison-of-algorithms-to-quantify-muscle-fatigue-in-upper-limb-muscles-based-on-semg-signals
#16
Lorenz Kahl, Ulrich G Hofmann
This work compared the performance of six different fatigue detection algorithms quantifying muscle fatigue based on electromyographic signals. Surface electromyography (sEMG) was obtained by an experiment from upper arm contractions at three different load levels from twelve volunteers. Fatigue detection algorithms mean frequency (MNF), spectral moments ratio (SMR), the wavelet method WIRM1551, sample entropy (SampEn), fuzzy approximate entropy (fApEn) and recurrence quantification analysis (RQA%DET) were calculated...
October 7, 2016: Medical Engineering & Physics
https://www.readbyqxmd.com/read/27679675/effect-of-cyp3a4-genetic-polymorphisms-on-the-genotoxicity-of-4-4-methylene-bis-2-chloroaniline-exposed-workers
#17
COMPARATIVE STUDY
Chung-Ching Wang, Wei-Liang Chen, Chia-Ni Hsiung, Sheng-Ta Chiang, Ying-Chuan Wang, Ching-Hui Loh, I-Shen Lin, Hong-I Chen, Saou-Hsing Liou
OBJECTIVES: We investigated the relationship between 4,4'-methylene-bis(2-chloroaniline) (MBOCA) exposure and micronucleus (MN) frequency, and how this association was affected by genetic polymorphism of the cytochrome P450 enzyme (CYP3A4). METHODS: We divided the study population into an exposed group (n=44 with total urine MBOCA ≥20 μg/g creatinine) and a control group (n=47 with total urine MBOCA <20 μg/g creatinine). Lymphocyte MN frequency (MNF) and micronucleated cell (MNC) frequency were measured by the cytokinesis-block MN assay method...
January 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27524022/fabrication-of-robust-antheraea-assama-fibroin-nanofibrous-mat-using-ionic-liquid-for-skin-tissue-engineering
#18
Chandra Mohan Srivastava, Roli Purwar
Electrospinning is an emerging technique used for fabrication of nanofibrous mats for skin tissue engineering applications. The aim of this study centered on fabrication of muga fibroin electrospun mats by using ionic liquid and its characterizations. The muga fibroin extracted from cocoon of Antheraea assama is dissolved in 1-butyl, 3-methyl imidazolium acetate (BMIMAc), a green solvent, to prepare a dope solution for electrospinning. The molecular weight, rheology and structural properties of dope solution are characterized...
November 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27423937/selective-gpr55-antagonism-reduces-chemoresistance-in-cancer-cells
#19
Nagendra S Singh, Michel Bernier, Irving W Wainer
G protein-coupled receptor 55 (GPR55) possesses pro-oncogenic activity and its function can be competitively inhibited with (R,R')-4'-methoxy-1-naphthylfenoterol (MNF) through poorly defined signaling pathways. Here, the anti-tumorigenic effect of MNF was investigated in the human pancreatic cancer cell line, PANC-1, by focusing on the expression of known cancer biomarkers and the expression and function of multidrug resistance (MDR) exporters such as P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP)...
September 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27421258/intensity-dependent-emg-response-for-the-biceps-brachii-during-sustained-maximal-and-submaximal-isometric-contractions
#20
Joshua C Carr, Travis W Beck, Xin Ye, Nathan P Wages
PURPOSE: There have been recent attempts to characterize the mechanisms associated with fatigue-induced task failure. We compared the time to failure and the corresponding changes in the surface electromyogram (EMG) during sustained maximal and submaximal isometric force tasks. METHODS: EMG activity was measured from the biceps brachii of 18 male participants as they sustained either a maximal or submaximal (60 % MVC) isometric contraction of the dominant elbow flexors until force could not be maintained above 55 % MVC...
September 2016: European Journal of Applied Physiology
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