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https://www.readbyqxmd.com/read/28724303/direct-percutaneous-endoscopic-jejunostomy-using-single-balloon-enteroscopy-without-fluoroscopy-a-case-series
#1
Carlos Bernardes, Rolando Pinho, Adélia Rodrigues, Luísa Proença, João Carvalho
BACKGROUND: Direct percutaneous endoscopic jejunostomy (DPEJ) is a useful method to provide enteral nutrition to individuals when gastric feeding is not possible or contraindicated. The aim of this study was to analyze the efficacy and safety of DPEJ tube placement with the Gauderer-Ponsky technique by the pull method, using single-balloon enteroscopy (SBE) without fluoroscopy. METHODS: This is a retrospective analysis of patients undergoing SBE for DPEJ placement in a referral hospital between January 2010 and March 2016...
July 14, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28717699/opportunistic-breast-cancer-education-and-screening-in-rural-honduras
#2
Linda S Kennedy, Suyapa A Bejarano, Tracy L Onega, Derek S Stenquist, Mary D Chamberlin
PURPOSE: In Honduras, the breast cancer burden is high, and access to women's health services is low. This project tested the connection of community-based breast cancer detection with clinical diagnosis and treatment in a tightly linked and quickly facilitated format. METHODS: The Norris Cotton Cancer Center at Dartmouth College partnered with the Honduran cancer hospital La Liga Contra el Cancer to expand a cervical cancer screening program, which included self-breast exam (SBE) education and clinical breast exams (CBEs), to assess patient attitudes about and uptake of breast cancer education and screening services...
August 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28715365/analysis-of-the-c-kit-ligand-promoter-using-chromatin-immunoprecipitation
#3
Pingyu Zhang, Andres Rojas, Boris Blechacz
Multiple cellular processes, including DNA replication and repair, DNA recombination, and gene expression, require interactions between proteins and DNA. Therefore, DNA-protein interactions regulate multiple physiological, pathophysiological, and biological functions, such as cell differentiation, cell proliferation, cell cycle control, chromosome stability, epigenetic gene regulation, and cell transformation. In eukaryotic cells, the DNA interacts with histone and nonhistone proteins and is condensed into chromatin...
June 27, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28710720/starch-accumulation-in-hulless-barley-during-grain-filling
#4
Xu-Guang Zheng, Jun-Cang Qi, Hong-Shan Hui, Li-Hao Lin, Feng Wang
BACKGROUND: Starch consists of two types of molecules: amylose and amylopectin. The objective of this study was increase understanding about mechanisms related to starch accumulation in hulless barley (Hordeum vulgare L.) grain by measuring temporal changes in (i) grain amylose and amylopectin content, (ii) starch synthase activity, and (iii) the relative expressions of key starch-related genes. RESULTS: The amylopectin/amylose ratio gradually declined in both Beiqing 6 and Kunlun 12...
December 2017: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/28689966/comparative-in-vitro-and-in-vivo-taste-assessment-of-liquid-praziquantel-formulations
#5
Magdalena Münster, Abeer H A Mohamed-Ahmed, Laura I Immohr, Corinna Schoch, Carsten Schmidt, Catherine Tuleu, Jörg Breitkreutz
The taste of pharmaceuticals strongly affects the compliance of patients. This study investigated the applicability of the electronic tongue and rodent brief-access taste aversion (BATA) model for the bitter compound praziquantel (PZQ) and taste masked liquid formulations for PZQ. In a comparative study maltodextrin (MD) Kleptose(®) linecaps 17 was selected as an alternative taste masking agent to two cyclodextrins; hydroxypropyl-beta-cyclodextrin (HP-β-CD) and sulfobutyl ether-beta-cyclodextrin (SBE-β-CD)...
July 8, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28675505/supramolecular-interactions-between-%C3%AE-lapachone-with-cyclodextrins-studied-using-isothermal-titration-calorimetry-and-molecular-modeling
#6
Francisco H Xavier-Junior, Marcelo M Rabello, Marcelo Z Hernandes, Marília E S Dias, Otoni H M S Andrada, Beatriz P Bezerra, Alejandro P Ayala, Nereide S Santos-Magalhães
Supramolecular interactions between β-lapachone (β-lap) and cyclodextrins (CDs) were investigated by isothermal titration calorimetry. The most favorable host: guest interaction was characterized using X-ray powder diffraction (XRD), differential scanning calorimetry and thermogravimetry (DSC/TG), spectroscopy (FT-IR), spectroscopy (2D ROESY) nuclear magnetic resonance (NMR), and molecular modeling. Phase solubility diagrams showed β-, HP-β-, SBE-β-, γ-, and HP-γ-CDs at 1.5% (w/w) allowed an increase in apparent solubility of β-lap with enhancement factors of 12...
July 4, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/28666165/a-novel-enantioseparation-approach-based-on-liposome-electrokinetic-capillary-chromatography
#7
Xiaoqi Li, Yingxiang Du, Zijie Feng, Xiaodong Sun, Zhifeng Huang
As a novel separation mode of capillary electrophoresis (CE), liposome electrokinetic capillary chromatography (LEKC) has aroused considerable attention in recent years; however, the enantioseparation based on this new system has not been previously investigated. In this study, we proposed a brand-new LEKC chiral separation approach using liposomes comprised of phosphatidylcholine (PC) and cholesterol as pseudo-stationary phase and sulfobutyl ether-β-cyclodextrin (SBE-β-CD) as chiral selector. Compared with the single CD system and CD-SDS-MEKC system, this LEKC method presented an obviously preferable enantioseparation of four model drugs (naproxen, warfarin, ketoprofen and amlodipine)...
June 6, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28659340/the-long-non-coding-rna-gas5-regulates-tgf-%C3%AE-induced-smooth-muscle-cell-differentiation-via-rna-smad-binding-element
#8
Rui Tang, Gui Zhang, Yung-Chun Wang, Xiaohan Mei, Shi-You Chen
Smooth muscle cell (SMC) differentiation is essential for vascular development, and TGF-β signaling plays a critical role in this process. Although long non-coding RNAs (lncRNAs) regulate various cellular events, their functions in SMC differentiation remain largely unknown. Here, we demonstrate that the lncRNA growth arrest specific 5 (GAS5) suppresses TGF-β/Smad3 signaling in smooth muscle cell differentiation of mesenchymal progenitor cells. We found that forced expression of GAS5 blocked, while knockdown of GAS5 increased, the expression of SMC contractile proteins...
June 28, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28652706/experimental-molecular-docking-investigations-and-bioavailability-study-on-the-inclusion-complexes-of-finasteride-and-cyclodextrins
#9
Fatma M Mady, Usama Farghaly Aly
Finasteride (FIN) is a Class II candidate of the Biopharmaceutics Classification System (BCS). The lipophilic cavity of cyclodextrins (CyDs) enables it to construct a non-covalent inclusion complex with different insoluble drugs. Only β-cyclodextrin (β-CyD) and hydroxypropyl-β-CyD (HP-β-CyD) have been previously examined with FIN. This study aimed to investigate the consistence of FIN with different kinds of β-CyDs, including dimethyl-β-cyclodextrin (DM-β-CyD), carboxymethyl-β-cyclodextrin (CM-β-CyD), HP-β-CyD, sulfobutyl ether-β-cyclodextrin (SBE-β-CyD), and β-CyD, by the coprecipitation method...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28622695/mir-23a-promotes-tgf-%C3%AE-1-induced-emt-and-tumor-metastasis-in-breast-cancer-cells-by-directly-targeting-cdh1-and-activating-wnt-%C3%AE-catenin-signaling
#10
Fei Ma, Wenjie Li, Chunxiao Liu, Wei Li, Haining Yu, Bo Lei, Yanlv Ren, Zhigao Li, Da Pang, Cheng Qian
TGF-β1-induced epithelial-mesenchymal transition (EMT) has been proved to be associated with metastasis of breast cancer cells. We attempted to detect a novel mechanism that microRNAs mediated the TGF-β1-induced EMT in the process of breast cancer metastasis. Here we reported that the expression of miR-23a was higher in breast cancer cells with high metastasis ability and patients with lymph node metastasis and the treatment of TGF-β1 significantly upregulated the expression of miR-23a in breast cancer cells...
June 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28585148/combined-use-of-single-balloon-enteroscope-and-colonoscope-for-self-expandable-metal-stent-placement-in-patients-with-malignant-small-intestinal-obstruction-a-single-center-comparative-clinical-observation
#11
Ya-Fei Zhang, Shou-Bin Ning, Bai-Rong Li, Jing Zhang, Jing Li, Jie Tang, Ming Zhu, Xiao-Wei Jin, Qiu Zhao, Gao-Ping Mao
Small intestinal obstruction is a common complication of primary gastrointestinal cancer or metastatic cancers. Patients with this condition are often poor candidates for surgical bypasses, and placement of self-expanding metal stent (SEMS) can be technically challenging. In this study, we examined the feasibility of combined application of single-balloon enteroscope (SBE) and colonoscope for SEMS placement in patients with malignant small intestinal obstruction. Thirty-four patients were enrolled in this study, among which 22 patients received SEMS placement by using SBE and colonoscope, while the other 12 patients received conservative medical treatment...
June 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28578566/enhanced-accessibility-of-polycyclic-aromatic-hydrocarbons-pahs-and-heterocyclic-pahs-in-industrially-contaminated-soil-after-passive-dosing-of-a-competitive-sorbate
#12
Stefan Humel, Stine N Schmidt, Marion Sumetzberger-Hasinger, Philipp Mayer, Andreas P Loibner
To assess the exposure to polycyclic aromatic hydrocarbons (PAHs) it is important to understand the binding mechanisms between specific soil constituents and the organic pollutant. In this study, sorptive bioaccessibility extraction (SBE) was applied to quantify the accessible PAH fraction in industrially contaminated soil with and without passive dosing of a competitive sorbate. SBE experiments revealed an accessible PAH fraction of 41 ± 1% (∑16 US EPA PAHs + 5 further PAHs). The passive dosing of toluene below its saturation level revealed competitive binding and resulted in an average increase of the accessible fraction to 49 ± 2%, whereby primarily the accessibility of higher molecular weight PAHs (log Kow > 6) was affected...
July 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28574838/histone-modifications-affect-differential-regulation-of-tgf%C3%AE-induced-nadph-oxidase-4-nox4-by-wild-type-and-mutant-p53
#13
Howard E Boudreau, Wei Feng Ma, Agnieszka Korzeniowska, Jonathan J Park, Medha A Bhagwat, Thomas L Leto
Previously, we showed wild-type (WT) and mutant (mut) p53 differentially regulate reactive oxygen species (ROS) generation by NADPH oxidase-4 (NOX4): p53-WT suppresses TGFβ-induced NOX4, ROS and cell migration, whereas tumor-associated mut-p53 proteins enhance NOX4 expression and cell migration. Here, we extended our findings on the effects of p53 on NOX4 in several tumors and examined the basis of NOX4 transcriptional regulation by p53 and SMAD3. Statistical analysis of expression data from primary tumors available from The Cancer Genome Atlas (TCGA) detected correlations between mut-p53 and increased NOX4 expression...
July 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28561892/microneedle-assisted-dc-targeted-codelivery-of-ptrp-2-and-adjuvant-of-paclitaxel-for-transcutaneous-immunotherapy
#14
Jiaojiao Xu, Beihua Xu, Jin Tao, Yunxu Yang, Ying Hu, Yongzhuo Huang
This work aims at developing an immunotherapeutic strategy to deliver a cancer DNA vaccine targeting dendritic cells (DCs), to trigger their maturation and antitumor function, and reduce immune escape using a polymeric nanocomplex of paclitaxel (PTX)-encapsulated sulfobutylether-β-cyclodextrin (SBE)/mannosylated N,N,N-trimethylchitosan (mTMC)/DNA. To enhance DC-targeting and revoke immunosuppression is the major challenge for eliciting effective antitumor immunity. This codelivery system is characterized by using low-dose PTX as an adjuvant that is included inside SBE, and the PTX/SBE further serves as an anionic crosslinker to self-assemble with the cationic mTMC/DNA polyplexes...
May 31, 2017: Small
https://www.readbyqxmd.com/read/28560528/success-of-percutaneous-endoscopic-gastrostomy-by-single-balloon-enteroscopy-in-patients-who-have-undergone-roux-en-y-gastric-bypass
#15
Eric Sellers, Andrew S Brock
Data is limited regarding the success and safety of percutaneous endoscopic gastrostomy (PEG) placements by single balloon enteroscopy (SBE) in patients with Roux-en-Y gastric bypass (RNY-GB) anatomy. We report on 23 cases of PEG placements by SBE with overall technical success of reaching the excluded stomach 70% and with PEG placement success rate of 69%. No intra-procedural adverse events occurred. This technique seems safe when feasible for PEG placement in patients with RNY-GB anatomy.
August 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28546841/the-effect-of-cyclodextrin-complexation-on-the-solubility-and-photostability-of-nerolidol-as-pure-compound-and-as-main-constituent-of-cabreuva-essential-oil
#16
Joyce Azzi, Pierre-Edouard Danjou, David Landy, Steven Ruellan, Lizette Auezova, Hélène Greige-Gerges, Sophie Fourmentin
Nerolidol (Ner), a major component of many plant essential oils, is known for its various biological properties. However, the low solubility of Ner in water and its susceptibility to degradation limit its application. The aim of our study was to improve the solubility and photostability of Ner through its encapsulation in different cyclodextrins (CDs). The formation constants of cis-, trans-Ner and their commercial mixture with various CDs (α-CD, β-CD, γ-CD, HP-β-CD, RAMEB, CRYSMEB and SBE-β-CD) were determined by phase solubility studies and confirmed by the spectral displacement UV-visible method...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28545442/anti-cancer-effect-of-scutellaria-baicalensis-in-combination-with-cisplatin-in-human-ovarian-cancer-cell
#17
Bo Yoon Choi, Jong Cheon Joo, Yeon Kyu Lee, Ik-Soon Jang, Soo Jung Park, Yoon Jung Park
BACKGROUND: Ovarian cancer is one of the major causes of death among females in worldwide. Cisplatin is a primary anti-cancer drug against ovarian cancer, but the recurrent tumors after treatment frequently show acquired chemoresistance. Extract of Scutellaria baicalensis (SbE) has been reported to have functional compounds including baicalin, which has anti-cancer effects. However, the anti-cancer effects of SbE in ovarian cancer and its underlying mechanisms are elusive. METHODS: We investigated that the effects of SbE and/or cisplatin on cell death in the cisplatin sensitive ovarian cancer cell line A2780 (CSC) and the counterpart cell line that has cisplatin resistance (CRC)...
May 25, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28542293/identification-and-expression-analysis-of-starch-branching-enzymes-involved-in-starch-synthesis-during-the-development-of-chestnut-castanea-mollissima-blume-cotyledons
#18
Liangke Chen, Dan Lu, Teng Wang, Zhi Li, Yanyan Zhao, Yichen Jiang, Qing Zhang, Qingqin Cao, Kefeng Fang, Yu Xing, Ling Qin
Chinese chestnut (Castanea mollissima Blume) is native to China and distributes widely in arid and semi-arid mountain area with barren soil. As a perennial crop, chestnut is an alternative food source and acts as an important commercial nut tree in China. Starch is the major metabolite in nuts, accounting for 46 ~ 64% of the chestnut dry weight. The accumulation of total starch and amylopectin showed a similar increasing trend during the development of nut. Amylopectin contributed up to 76% of the total starch content at 80 days after pollination (DAP)...
2017: PloS One
https://www.readbyqxmd.com/read/28533545/treatment-effects-of-the-traditional-chinese-medicine-shenks-in-bleomycin-induced-lung-fibrosis-through-regulation-of-tgf-beta-smad3-signaling-and-oxidative-stress
#19
Haiyan Chu, Ying Shi, Shuai Jiang, Qicheng Zhong, Yongqiang Zhao, Qingmei Liu, Yanyun Ma, Xiangguang Shi, Weifeng Ding, Xiaodong Zhou, Jimin Cui, Li Jin, Gang Guo, Jiucun Wang
Pulmonary fibrosis is a kind of devastating interstitial lung disease due to the limited therapeutic strategies. Traditional Chinese medicine (TCM) practices have put forth Shenks as a promising treatment approach. Here, we performed in vivo study and in vitro study to delineate the anti-fibrotic mechanisms behind Shenks treatment for pulmonary fibrosis. We found that regardless of the prophylactic or therapeutic treatment, Shenks was able to attenuate BLM-induced-fibrosis in mice, down regulate extracellular matrix genes expression, and reduce collagen production...
May 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28529602/super-aqueous-solubility-of-albendazole-in-%C3%AE-cyclodextrin-for-parenteral-application-in-cancer-therapy
#20
Krishna Pillai, Javed Akhter, David Lawson Morris
Poor aqueous solubility of anticancer drug, albendazole (ABZ), prevents parenteral application. Here, we demonstrate how to increase the aqueous solubility of ABZ to 6- 8 mg/ml using sulfobutylether - β-cyclodextrin (SBE-β-CD) or Hydroxypropyl- β-cyclodextrin (HP- β-CD) by manipulation of complexation parameters such as the physical state of ABZ (ionized in acetic acid), the concentration of ionised ABZ, agitation time and temperature. Solubility was first examined with suspension of excess ABZ powder in cyclodextrin (CD) solutions at pH (2...
2017: Journal of Cancer
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