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https://www.readbyqxmd.com/read/29730228/an-international-multicenter-comparative-trial-of-eus-guided-gastrogastrostomy-assisted-ercp-versus-enteroscopy-assisted-ercp-in-patients-with-roux-en-y-gastric-bypass-anatomy
#1
Majidah Bukhari, Thomas Kowalski, Jose Nieto, Rastislav Kunda, Nitin K Ahuja, Shayan Irani, Apeksha Shah, David Loren, Olaya Brewer, Omid Sanaei, Lea Fayad, Yen-I Chen, Saowanee Ngamruengphong, Vivek Kumbhari, Vikesh Singh, Hanaa Dakour Aridi, Mouen A Khashab
BACKGROUND & AIMS: ERCP is challenging in patients with Roux-en-Y gastric bypass (RYGB) anatomy. EUS-guided gastrogastrostomy (GG) creation is a promising novel technique to access the excluded stomach in order to facilitate conventional ERCP. We aimed to compare procedural outcomes and adverse events (AEs) between EUS-guided gastrogastrostomy-assisted ERCP (EUS-GG-ERCP) and enteroscopy assisted ERCP (e-ERCP) in patients with RYGB. METHODS: Patients with RYGB anatomy who underwent EUS-GG-ERCP or e-ERCP between 2014 and 2016 at 5 tertiary centers were included...
May 3, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29723543/the-transcription-factor-smad4-and-mir-10b-contribute-to-e2-release-and-cell-apoptosis-in-ovarian-granulosa-cells-by-targeting-cyp19a1
#2
Qiqi Li, Xing Du, Zengxiang Pan, Lifan Zhang, Qifa Li
The cytochrome P450 family 19 subfamily A member 1 (CYP19A1) gene, encodes aromatase, a key enzyme in estradiol (E2) synthesis, and is down-regulated during porcine follicular atresia. However, its role in and the mechanism of transcriptional repression in follicular atresia is largely unknown. In the present study, we show that the CYP19A1 gene stimulates E2 release and inhibits cell apoptosis in porcine granulosa cells (GCs). SMAD4, an anti-apoptotic moderator, was identified as a transcription factor of the porcine CYP19A1 gene and enhanced the expression and function of CYP19A1 in porcine GCs through direct binding to a SMAD4-binding element (SBE) within the promoter region of CYP19A1 gene...
April 30, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29682531/identification-of-forensically-important-calliphoridae-and-sarcophagidae-species-collected-in-korea-using-snapshot-multiplex-system-targeting-the-cytochrome-c-oxidase-subunit-i-gene
#3
Ji Hye Park, Sang Eon Shin, Kwang Soo Ko, Seong Hwan Park
Estimation of postmortem interval (PMI) is paramount in modern forensic investigation. After the disappearance of the early postmortem phenomena conventionally used to estimate PMI, entomologic evidence provides important indicators for PMI estimation. The age of the oldest fly larvae or pupae can be estimated to pinpoint the time of oviposition, which is considered the minimum PMI (PMImin ). The development rate of insects is usually temperature dependent and species specific. Therefore, species identification is mandatory for PMImin estimation using entomological evidence...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29663468/problematic-eating-behaviors-and-psychopathology-in-patients-undergoing-bariatric-surgery-the-mediating-role-of-loss-of-control-eating
#4
Eva M Conceição, Marta de Lourdes, Ana Pinto-Bastos, Ana Rita Vaz, Isabel Brandão, Sofia Ramalho
OBJECTIVE: This study compares different problematic eating behaviors (PEBs; objective [OBE]/subjective [SBE] binge-eating and compulsive [CG]/noncompulsive [NCG] grazing) in relation to the severity of loss of control (LOC) and psychopathology. We also investigate LOC as a mediator between PEBs and psychopathology. METHOD: This cross-sectional study assessed a group of patients before bariatric surgery (n = 163), and a group of bariatric patients 12 months or more after surgery (n = 131)...
April 17, 2018: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29563620/il-17-receptor-associated-adaptor-act1-directly-stabilizes-mrnas-to-mediate-il-17-inflammatory-signaling
#5
Tomasz Herjan, Lingzi Hong, Jodi Bubenik, Katarzyna Bulek, Wen Qian, Caini Liu, Xiao Li, Xing Chen, Hui Yang, Suidong Ouyang, Hao Zhou, Junjie Zhao, Kommireddy Vasu, Eric Cockman, Mark Aronica, Kewal Asosingh, Donny D Licatalosi, Jun Qin, Paul L Fox, Thomas A Hamilton, Donna Driscoll, Xiaoxia Li
Mechanisms that degrade inflammatory mRNAs are well known; however, stabilizing mechanisms are poorly understood. Here, we show that Act1, an interleukin-17 (IL-17)-receptor-complex adaptor, binds and stabilizes mRNAs encoding key inflammatory proteins. The Act1 SEFIR domain binds a stem-loop structure, the SEFIR-binding element (SBE), in the 3' untranslated region (UTR) of Cxcl1 mRNA, encoding an inflammatory chemokine. mRNA-bound Act1 directs formation of three compartmentally distinct RNA-protein complexes (RNPs) that regulate three disparate events in inflammatory-mRNA metabolism: preventing mRNA decay in the nucleus, inhibiting mRNA decapping in P bodies and promoting translation...
April 2018: Nature Immunology
https://www.readbyqxmd.com/read/29545687/effects-of-elastic-band-exercises-on-physical-ability-and-muscular-topography-of-elderlyfemales
#6
Jung Won Lee, Suk Bum Kim, Seong Wook Kim
[Purpose] This study examined the effects of band exercise types on the physical ability and muscular topography for elderly females. [Subjects and Methods] Twenty-six females older than 65 years were divided into the dynamic band exercise (DBE; n=13) group and the Static band exercise (SBE; n=13) group. Each participant performed 12 weeks of elastic band exercises. Physical abilities were measured by leg extension power, sitting trunk flexion, closed eyes foot balance, and time to get up. Changes in muscle topography were evaluated with Moire measurement equipment for the chest, abdomen, and lumbar region...
February 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29540822/grain-yield-starch-content-and-activities-of-key-enzymes-of-waxy-and-non-waxy-wheat-triticum-aestivum-l
#7
Yan Zi, Jinfeng Ding, Jianmin Song, Gavin Humphreys, Yongxin Peng, Chunyan Li, Xinkai Zhu, Wenshan Guo
Waxy wheat has unique end-use properties; however, its production is limited due mainly to its low grain yield compared with non-waxy wheat. In order to increase its grain yield, it is critical to understand the eco-physiological differences in grain filling between the waxy and non-waxy wheat. In this study, two waxy wheat and two non-waxy wheat cultivars were used to investigate the differences in starch-associated enzymes processes, sucrose and starch dynamics, yield components, and the final grain yield...
March 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29539652/small-bowel-capsule-endoscopy-and-device-assisted-enteroscopy-for-diagnosis-and-treatment-of-small-bowel-disorders-european-society-of-gastrointestinal-endoscopy-esge-technical-review
#8
Emanuele Rondonotti, Cristiano Spada, Samuel Adler, Andrea May, Edward J Despott, Anastasios Koulaouzidis, Simon Panter, Dirk Domagk, Ignacio Fernandez-Urien, Gabriel Rahmi, Maria Elena Riccioni, Jeanin E van Hooft, Cesare Hassan, Marco Pennazio
SMALL-BOWEL CAPSULE ENDOSCOPY (SBCE): 1: ESGE recommends that prior to SBCE patients ingest a purgative (2 L of polyethylene glycol [PEG]) for better visualization.Strong recommendation, high quality evidence.However, the optimal timing for taking purgatives is yet to be established. 2: ESGE recommends that SBCE should be performed as an outpatient procedure if possible, since completion rates are higher in outpatients than in inpatients.Strong recommendation, moderate quality evidence...
March 14, 2018: Endoscopy
https://www.readbyqxmd.com/read/29490076/advancing-simulation-based-education-in-pain-medicine
#9
Naileshni Singh, Alison A Nielsen, David J Copenhaver, Samir J Sheth, Chin-Shang Li, Scott M Fishman
Background: The Accreditation Council for Graduate Medical Education (ACGME) has recently implemented milestones and competencies as a framework for training fellows in Pain Medicine, but individual programs are left to create educational platforms and assessment tools that meet ACGME standards. Objectives: In this article, we discuss the concept of milestone-based competencies and the inherent challenges for implementation in pain medicine. We consider simulation-based education (SBE) as a potential tool for the field to meet ACGME goals through advancing novel learning opportunities, engaging in clinically relevant scenarios, and mastering technical and nontechnical skills...
February 27, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29459192/investigating-the-impact-of-moulage-on-simulation-engagement-a-systematic-review
#10
REVIEW
Jessica B Stokes-Parish, Robbert Duvivier, Brian Jolly
BACKGROUND: Simulation Based Education (SBE) is used as a primer for clinical education in nursing and other health professions. Participant engagement strategies and good debriefing have been identified as key for effective simulations. The environment in which the simulation is situated also plays a large role in the degree of participant engagement. Various cues are staged within simulations to enhance this engagement process. Moulage techniques are used in current-day simulation to mimic illnesses and wounds, acting as visual and tactile cues for the learner...
May 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29453067/applying-no-depletion-equilibrium-sampling-and-full-depletion-bioaccessibility-extraction-to-35-historically-polycyclic-aromatic-hydrocarbon-contaminated-soils
#11
Nora Bartolomé, Isabel Hilber, Dayana Sosa, Rainer Schulin, Philipp Mayer, Thomas D Bucheli
Assessing the bioaccessibility of organic pollutants in contaminated soils is considered a complement to measurements of total concentrations in risk assessment and legislation. Consequently, methods for its quantification require validation with historically contaminated soils. In this study, 35 such soils were obtained from various locations in Switzerland and Cuba. They were exposed to different pollution sources (e.g., pyrogenic and petrogenic) at various distance (i.e., urban to rural) and were subject to different land use (e...
May 2018: Chemosphere
https://www.readbyqxmd.com/read/29450027/faculty-development-through-simulation-based-education-in-physical-therapist-education
#12
Kristin Curry Greenwood, Sara B Ewell
Background: The use of simulation-based education (SBE) in health professions, such as physical therapy, requires faculty to expand their teaching practice and development. The impact of this teaching on the individual faculty member, and how their teaching process changes or develops, is not fully understood. The purpose of this study was to explore individual physical therapist faculty members' experience with SBE and how those experiences may have transformed their teaching practice to answer the research questions: How do physical therapist faculty develop through including SBE and are there commonalities among educators? Methods: An interpretive phenomenological analysis approach was used with a small sample of subjects who participated in three individual semi-structured interviews...
2018: Advances in Simulation
https://www.readbyqxmd.com/read/29398926/a-randomized-controlled-trial-comparing-the-depth-of-maximal-insertion-between-anterograde-single-balloon-versus-spiral-enteroscopy
#13
Robert A Moran, Sindhu Barola, Joanna K Law, Stuart K Amateau, Daniil Rolshud, Erin Corless, Vandhana Kiswani, Vikesh K Singh, Anthony N Kalloo, Mouen A Khashab, Anne Marie Lennon, Patrick I Okolo, Vivek Kumbhari
Background: Three device-assisted deep endoscopic platforms presently exist and are available for clinical use: double-balloon enteroscopy, single-balloon enteroscopy (SBE), and spiral enteroscopy (SE). In a retrospective study, SE was associated with a greater depth of maximal insertion (DMI) with similar diagnostic yields and procedure time as compared with SBE. Aims: This was a prospective, randomized comparison of SE and SBE with respect to DMI, diagnostic yield, procedure time, and rate of adverse events...
2018: Clinical Medicine Insights. Gastroenterology
https://www.readbyqxmd.com/read/29343763/association-of-s100b-polymorphisms-and-serum-s100b-with-risk-of-ischemic-stroke-in-a-chinese-population
#14
Yu-Lan Lu, Rong Wang, Hua-Tuo Huang, Hai-Mei Qin, Chun-Hong Liu, Yang Xiang, Chun-Fang Wang, Hong-Cheng Luo, Jun-Li Wang, Yan Lan, Ye-Sheng Wei
The levels of serum S100B were elevated in patients with ischemic stroke (IS), which may be a novel biomarker for diagnosing IS. The aim of this study was to investigate the association of S100B polymorphisms and serum S100B with IS risk. We genotyped the S100B polymorphisms rs9722, rs9984765, rs2839356, rs1051169 and rs2186358 in 396 IS patients and 398 controls using polymerase chain reaction-single base extension (SBE-PCR). Serum S100B levels were measured by enzyme-linked immunosorbent assay (ELISA). Rs9722 was associated with an increased risk of IS (AA vs...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29334130/radiofrequency-ablation-combined-with-multiple-biliary-metal-stent-placement-using-short-type-single-balloon-endoscope-in-patients-with-surgically-altered-anatomy
#15
Tadahisa Inoue, Kiyoaki Ito, Masashi Yoneda
No abstract text is available yet for this article.
January 15, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29310584/long-branch-chains-of-amylopectin-with-b-type-crystallinity-in-rice-seed-with-inhibition-of-starch-branching-enzyme-i-and-iib-resist-in-situ-degradation-and-inhibit-plant-growth-during-seedling-development-degradation-of-rice-starch-with-inhibition-of-sbei
#16
Ting Pan, Lingshang Lin, Juan Wang, Qiaoquan Liu, Cunxu Wei
BACKGROUND: Endosperm starch provides prime energy for cereal seedling growth. Cereal endosperm with repression of starch branching enzyme (SBE) has been widely studied for its high resistant starch content and health benefit. However, in barley and maize, the repression of SBE changes starch component and amylopectin structure which affects grain germination and seedling establishment. A high resistant starch rice line (TRS) has been developed through inhibiting SBEI/IIb, and its starch has very high resistance to in vitro hydrolysis and digestion...
January 8, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29287323/propyl-gallate-cyclodextrin-supramolecular-complexes-with-enhanced-solubility-and-radical-scavenging-capacity
#17
Qian Li, Hongyu Pu, Peixiao Tang, Bin Tang, Qiaomei Sun, Hui Li
This study prepared and investigated the inclusion complexes of propyl gallate (PG) with beta-cyclodextrin (β-CD) and its water-soluble derivatives dimethyl-beta-cyclodextrin (DM-β-CD), hydroxypropyl-beta-cyclodextrin (HP-β-CD), and sulfobutylether-beta-cyclodextrin (SBE-β-CD). Phase solubility studies indicated that the formed complexes were in 1:1 stoichiometry. FT-IR, PXRD, DSC,1 H-NMR, ROESY-NMR, and SEM analysis results confirmed the formation of the complexes. The NMR results indicated that the aromatic ring of PG was embedded into the CD cavity...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29211341/chiral-separation-of-lenalidomide-by-liquid-chromatography-on-polysaccharide-type-stationary-phases-and-by-capillary-electrophoresis-using-cyclodextrin-selectors
#18
Zoltán-István Szabó, Mohammadhassan Foroughbakhshfasaei, Réka Gál, Péter Horváth, Balázs Komjáti, Béla Noszál, Gergő Tóth
Complementary techniques were applied for the investigation of the chiral recognition and enantiomeric resolution of lenalidomide using various cyclodextrins and polysaccharides as chiral selectors. The high-performance liquid chromatography enantioseparation of the anticancer drug was achieved using polysaccharide-type chiral stationary phases in polar organic mode. Elution order and absolute configuration were elucidated by combined circular dichroism spectroscopy and time-dependent density functional theory calculations after the isolation of pure enantiomers...
December 6, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29166855/identification-of-differentially-expressed-genes-in-flower-leaf-and-bulb-scale-of-lilium-oriental-hybrid-sorbonne-and-putative-control-network-for-scent-genes
#19
Fang Du, Junmiao Fan, Ting Wang, Yun Wu, Donald Grierson, Zhongshan Gao, Yiping Xia
BACKGROUND: Lily is an economically important plant, with leaves and bulbs consisting of overlapping scales, large ornamental flowers and a very large genome. Although it is recognized that flowers and bulb scales are modified leaves, very little is known about the genetic control and biochemical differentiation underlying lily organogenesis and development. Here we examined the differentially expressed genes in flower, leaf and scale of lily, using RNA-sequencing, and identified organ-specific genes, including transcription factors, genes involved in photosynthesis in leaves, carbohydrate metabolism in bulb scales and scent and color production in flowers...
November 22, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29154400/a-chiral-enantioseparation-generic-strategy-for-anti-alzheimer-and-antifungal-drugs-by-short-end-injection-capillary-electrophoresis-using-an-experimental-design-approach
#20
Ahmed M Abdel-Megied, Rasha S Hanafi, Hassan Y Aboul-Enein
The present study describes a generic strategy using capillary electrophoretic (CE) method for chiral enantioseparation of anti-Alzheimer drugs, namely, donepezil (DON), rivastigmine (RIV), and antifungal drugs, namely, ketoconazole (KET), Itraconazole (ITR), fluconazole (FLU), and sertaconazole (SRT) in which these drugs have different basic and acidic properties. Several modified cyclodextrins (CDs) were applied for enantioseparation of racemates such as highly sulfated α, γ CDs, hydroxyl propyl-β-CD, and Sulfobutyl ether-β-CD...
February 2018: Chirality
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