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https://www.readbyqxmd.com/read/28644055/regulation-of-transient-receptor-potential-melastatin-4-channel-by-sarcoplasmic-reticulum-inositol-triphosphate-receptors-role-in-human-detrusor-smooth-muscle-function
#1
Aaron Provence, Eric S Rovner, Georgi V Petkov
We recently reported key physiological roles for Ca(2+)-activated transient receptor potential melastatin 4 (TRPM4) channels in detrusor smooth muscle (DSM). However, the Ca(2+)-signaling mechanisms governing TRPM4 channel activity in human DSM cells are unexplored. As the TRPM4 channels are activated by Ca(2+), inositol 1,4,5-trisphosphate receptor (IP3R)-mediated Ca(2+) release from the sarcoplasmic reticulum represents a potential Ca(2+) source for TRPM4 channel activation. We used clinically-characterized human DSM tissues to investigate the molecular and functional interactions of the IP3Rs and TRPM4 channels...
June 23, 2017: Channels
https://www.readbyqxmd.com/read/28640990/opiate-antagonists-do-not-interfere-with-the-clinical-benefits-of-stimulants-in-adhd-a-double-blind-placebo-controlled-trial-of-the-mixed-opioid-receptor-antagonist-naltrexone
#2
Thomas J Spencer, Pradeep Bhide, Jinmin Zhu, Stephen V Faraone, Maura Fitzgerald, Amy M Yule, Mai Uchida, Andrea E Spencer, Anna M Hall, Ariana J Koster, Joseph Biederman
OBJECTIVE: Methylphenidate activates μ-opioid receptors, which are linked to euphoria. μ-Opioid antagonists, such as naltrexone, may attenuate the euphoric effects of stimulants, thereby minimizing their abuse potential. This study assessed whether the combination of naltrexone with methylphenidate is well-tolerated while preserving the clinical benefits of stimulants in subjects with attention-deficit/hyperactivity disorder (ADHD). METHODS: We conducted a 6-week, double-blind, placebo-controlled, randomized clinical trial of naltrexone in adults with DSM-IV ADHD receiving open treatment with a long-acting formulation of methylphenidate from January 2013 to July 2015...
June 20, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28639377/validating-the-social-responsiveness-scale-for-adults-with-autism
#3
Wai Chan, Leann E Smith, Jinkuk Hong, Jan S Greenberg, Marsha R Mailick
The Social Responsiveness Scale [SRS; Constantino & Gruber, 2005] is a widely-used measure of autism symptoms, but its application for the study of adults with autism spectrum disorders has not been fully evaluated. Using a factor structure consistent with The Diagnostic and Statistical Manual of Mental Disorders (5th ed., DSM-V) criteria for autism spectrum disorder [Frazier et al., 2014], the primary purpose of the current study was to establish the validity of the SRS with a sample of adults with autism spectrum disorder (N = 237)...
June 22, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28638029/-pharmacotherapy-of-attention-deficit-hyperactivity-disorder-in-children-the-results-of-a-multicenter-double-blind-placebo-controlled-study-of-hopantenic-acid
#4
N N Zavadenko, N Yu Suvorinova, I N Vakula, E V Malinina, L M Kuzenkova
AIM: To assess the efficacy and safety of hopantenic acid (pantogam) compared to placebo in the treatment of attention deficit hyperactivity disorder (ADHD) in children, aged from 6 to 12 years, during 4 month in the prospective multicenter comparative double-blind placebo-controlled study in parallel groups. MATERIAL AND METHODS: One hundred patients enrolled in the safety assessment population were stratified into two equal pantogam and placebo groups. Eighty-nine patients who completed the study in according to the protocol were included in the efficacy assessment group: 45 in the pantogam group and 44 in the placebo group...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28637449/task-shifting-interpersonal-counseling-for-depression-a-pragmatic-randomized-controlled-trial-in-primary-care
#5
Camila T Matsuzaka, Milton Wainberg, Andrea Norcini Pala, Elis V Hoffmann, Bruno M Coimbra, Rosaly F Braga, Annika C Sweetland, Marcelo F Mello
BACKGROUND: Task shifting approaches (rational redistribution of tasks among health workforce teams) to train lay professionals to assist with integrating mental health treatment in primary care has been recommended to close the mental health treatment gap for depression in low- and middle-income countries. This study aims to examine the a new model for depression care in a low-resource environment compared to enhanced treatment at usual (E-TAU). METHODS: We trained non-specialist community health workers (local lay employees of the public health system) to provide Interpersonal Counseling (IPC) to treat depressive symptoms in the Brazilian, São Paulo city, family health strategy (FHS)...
June 21, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28632115/flaviaesturariibacter-luteus-sp-nov-isolated-from-an-agricultural-floodplain-soil-and-emended-description-of-the-genus-flaviaesturariibacter
#6
Javier Pascual, Bärbel U Foesel, Alicia Geppert, Katharina J Huber, Jörg Overmann
A novel slow-growing bacterial strain designated as AW305T was isolated from an agricultural floodplain soil located in Mashare, Kavango region, Namibia. Cells stained Gram-negative, were non-motile, non-spore-forming, coccoid to rod-shaped and did not form a capsule. Colonies were yellow-pigmented, but flexirubin-type pigments were not detected. AW305T had an aerobic chemo-organoheterotrophic metabolism, using a narrow spectrum of carbon sources for growth, with preference for complex protein substrates, organic acids and amino acids...
June 20, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28629509/actinomyces-vulturis-sp-nov-isolated-from-gyps-himalayensis
#7
Xiangli Meng, Shan Lu, Yiting Wang, Xin-He Lai, Yumeng Wen, Dong Jin, Jing Yang, Xiangning Bai, Gui Zhang, Ji Pu, Riuting Lan, Jianguo Xu
Two strains of Gram-stain-positive, facultatively anaerobic, non-spore-forming short rods (VUL7T and VUL8) were isolated from rectal swabs of Old World vultures, namely Gyps himalayensis, in Tibet-Qinghai Plateau, China. Optimal growth occurred at 37 °C, pH 6-7, with 1 % (w/v) NaCl. Phylogenetic analysis based on 16S rRNA gene sequences classified the two strains to the genus Actinomyces, with highest 16S rRNA gene sequence similarity (95 %) to type strains of Actinomyces haliotis, Actinomyces radicidentis and Actinomyces urogenitalis...
June 20, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28629506/actinomyces-liubingyangii-sp-nov-isolated-from-the-vulture-gypaetus-barbatus
#8
Xiangli Meng, Shan Lu, Xin-He Lai, Yiting Wang, Yumeng Wen, Dong Jin, Jing Yang, Jianguo Xu
Two strains (VUL4_1T and VUL4_2) of Gram-staining-positive, catalase-negative, non-spore-forming short rods were isolated from rectal swabs of Old World vultures (Gypaetus barbatus) in the Tibet-Qinghai Plateau, China. Analysis of morphological characteristics and biochemical tests indicated that the two strains closely resembled each other but were distinct from other species of the genus Actinomyces previously described. Based on the results of 16S rRNA gene sequence comparison and genome analysis, strains were determined to be members of the genus Actinomyces, closely related to the type strains of Actinomyces marimammalium (96...
June 20, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28629493/naumannella-huperziae-sp-nov-an-endophytic-actinobacterium-isolated-from-huperzia-serrata-thunb
#9
Ye Sun, Hua-Hong Chen, Hong-Min Sun, Meng-Jie Ai, Jing Su, Li-Yan Yu, Yu-Qin Zhang
An endophytic, short rod-shaped, non-motile and non-spore-forming actinobacterium, designated strain CPCC 204135T, was isolated from a surface-sterilized medicinal plant, Huperzia serrata (Thunb.), collected from Sichuan Province, south-west China. Strain CPCC 204135T was observed to grow at temperatures between 20 and 37 °C (optimum, 28-32 °C), at pH 6.0-9.0 (optimum, pH 7.0-8.0) and in the presence of 0-9.0 % (w/v) NaCl (optimum, 0-3 %). Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain CPCC 204135T belonged to the genus Naumannella, showing the highest level of 16S rRNA gene sequence similarity with Naumannella halotolerans DSM 24323T (97...
June 20, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28625214/post-traumatic-stress-disorder-associated-with-sexual-assault-among-women-in-the-who-world-mental-health-surveys
#10
K M Scott, K C Koenen, A King, M V Petukhova, J Alonso, E J Bromet, R Bruffaerts, B Bunting, P de Jonge, J M Haro, E G Karam, S Lee, M E Medina-Mora, F Navarro-Mateu, N A Sampson, V Shahly, D J Stein, Y Torres, A M Zaslavsky, R C Kessler
BACKGROUND: Sexual assault is a global concern with post-traumatic stress disorder (PTSD), one of the common sequelae. Early intervention can help prevent PTSD, making identification of those at high risk for the disorder a priority. Lack of representative sampling of both sexual assault survivors and sexual assaults in prior studies might have reduced the ability to develop accurate prediction models for early identification of high-risk sexual assault survivors. METHODS: Data come from 12 face-to-face, cross-sectional surveys of community-dwelling adults conducted in 11 countries...
June 19, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28623565/the-novel-oleaginous-bacterium-sphingomonas-sp-egy1-dsm-29616-a-value-added-platform-for-renewable-biodiesel
#11
Nehad N Amer, Yasser Elbahloul, Amira M Embaby, Ahmed Hussein
Oleaginous microorganisms are regarded as efficient, renewable cell factories for lipid biosynthesis, a biodiesel precursor, to overwhelm the cosmopolitan energy crisis with affordable investment capital costs. Present research highlights production and characterization of lipids by a newly isolated oleaginous bacterium, Sphingomonas sp. EGY1 DSM 29616 through an eco-friendly approach. Only sweet whey [42.1% (v/v)] in tap water was efficiently used as a growth medium and lipid production medium to encourage cell growth and trigger lipid accumulation simultaneously...
July 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28615756/neurocognitive-impairments-in-unaffected-first-degree-relatives-of-schizophrenia
#12
Virupaksha Shanmugam Harave, Venkataram Shivakumar, Sunil V Kalmady, Janardhanan C Narayanaswamy, Shivarama Varambally, Ganesan Venkatasubramanian
BACKGROUND: Neurocognitive impairments of attention and executive functioning are trait abnormalities in schizophrenia, and these are considered to be endophenotypes. These deficits have been convincingly linked to prefrontal cortical functioning. In this study, we examined the cognitive performance in the domains of attention and executive functioning among first-degree relatives of Indian people with schizophrenia (high-risk [HR] patients) compared to healthy controls (HC). MATERIALS AND METHODS: Siblings of patients with DSM-IV schizophrenia, HR patients (n = 17), were compared with HC (n = 30) (matched as a group for age, sex, years of education, and handedness) using the following neurocognitive tests for attention and executive function - digit span test (DST), trail making test, letter-number sequencing (LNS), and spatial span test...
May 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28613148/sphingopyxis-solisilvae-sp-nov-isolated-from-forest-soil
#13
Dhiraj Kumar Chaudhary, Ram Hari Dahal, Jaisoo Kim
A yellow-coloured, Gram-staining-negative, motile and rod shaped bacterium, designated strain R366T, was isolated from forest soil of Kyonggi University, South Korea. It was able to grow at 15-42 °C, pH 6.0-10.0 and with 0-4 % (w/v) NaCl concentration. Based on the 16S rRNA gene sequence analysis, strain R366T belongs to the genus Sphingopyxis and is closely related to Sphingopyxis italica SC13E-S71T (98.72 % sequence similarity), Sphingopyxis chilensis S37T (98.51 %), Sphingopyxis fribergensis Kp5...
June 14, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28600874/loose-regulation-of-medical-marijuana-programs-associated-with-higher-rates-of-adult-marijuana-use-but-not-cannabis-use-disorder
#14
Arthur Robin Williams, Julian Santaella-Tenorio, Christine M Mauro, Frances R Levin, Silvia S Martins
BACKGROUND AND AIMS: Most U.S. states have passed medical marijuana laws (MMLs), with great variation in program regulation impacting enrollment rates. We aimed to compare changes in rates of marijuana use, heavy use, and Cannabis Use Disorder across age groups while accounting for whether states enacted medicalized (highly regulated) or non-medical MML programs. DESIGN: Difference-in-differences estimates with time-varying state-level MML coded by program type (medicalized v...
June 10, 2017: Addiction
https://www.readbyqxmd.com/read/28599348/a-pilot-open-label-8-week-study-evaluating-the-efficacy-safety-and-tolerability-of-adjunctive-minocycline-for-the-treatment-of-bipolar-i-ii-depression
#15
Joanna K Soczynska, Sidney H Kennedy, Mohammad Alsuwaidan, Rodrigo B Mansur, Madeline Li, Mary Pat McAndrews, Elisa Brietzke, Hanna O Woldeyohannes, Valerie H Taylor, Roger S McIntyre
OBJECTIVES: The objectives of the study were to determine if adjunctive minocycline mitigates depressive symptom severity and improves cognitive function in individuals with bipolar I/II disorder (BD). The study also aimed to determine if changes in depressive and/or cognitive symptoms over the course of treatment were associated with changes in circulating inflammatory cytokine levels. METHODS: A total of 29 (intention-to-treat: n=27) adults meeting DSM-IV-TR criteria for a major depressive episode as part of bipolar I or II disorder (i...
May 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28598955/the-comorbidity-of-daydreaming-disorder-maladaptive-daydreaming
#16
Eli Somer, Nirit Soffer-Dudek, Colin A Ross
To determine the comorbidity profile of individuals meeting criteria for a proposed new disorder, daydreaming disorder (more commonly known as maladaptive daydreaming [MD]), the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) and the Structured Clinical Interview for DSM-IV Dissociative Disorders were administered to 39 participants who met criteria for MD on a structured interview. We determined high rates of comorbidity: 74.4% met criteria for more than three additional disorders, and 41...
June 8, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28598303/caulobacter-rhizosphaerae-sp-nov-a-stalked-bacterium-isolated-from-rhizosphere-soil
#17
Le-Ni Sun, En-Dong Yang, Xue-Ting Hou, Jie-Chao Wei, Zhuo-Xin Yuan, Wei-Yun Wang
The Gram-reaction-negative, aerobic, white- to pale-yellow-coloured and rod-shaped bacterium with a single polar flagellum or a stalk, designated strain 7F14T, was isolated from rhizosphere soil of cultivated watermelon (Citrullus lanatus) collected from Hefei, China. Growth of strain 7F14T was observed at pH 6.0-9.0, 10-30 °C and in the presence of 0-1 % (w/v) NaCl. Cells were catalase-negative and oxidase-positive. Phylogenetic analyses based on 16S rRNA gene sequences indicated that strain 7F14T formed a phyletic lineage within the genus Caulobacter of the family Caulobacteraceae and showed the highest 16S rRNA gene sequence similarities to Caulobacter henricii ATCC 15253T (98...
June 9, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28596906/pattern-of-impairments-and-late-diagnosis-of-autism-spectrum-disorder-among-a-sub-saharan-african-clinical-population-of-children-in-nigeria
#18
M A Bello-Mojeed, O O Omigbodun, M O Bakare, A O Adewuya
BACKGROUND: Autism spectrum disorder (ASD) is a complex group of neurodevelopmental disorders. Studies conducted among Africans living outside the continent indicate that African children are more likely than Caucasian children to have a late diagnosis of ASD. There is a dearth of information on this topic among children with ASD living in Africa. METHODS: To determine the pattern of impairments and age at diagnosis in ASD, sixty Nigerian children with a diagnosis of ASD were recruited from a neurodevelopmental clinic...
2017: Global Mental Health
https://www.readbyqxmd.com/read/28594055/influence-of-attention-deficit-hyperactivity-disorder-symptoms-on-quality-of-life-and-functionality-in-adults-with-eating-disorders
#19
Francisco Ferre, Julia Cambra, Mercedes Ovejero, Ignacio Basurte-Villamor
INTRODUCTION: Eating disorders (ED) have been linked to attention deficit hyperactivity disorder (ADHD) because they present some symptoms in common. The aim of this study was to explore the influence on ED of symptoms suggestive of adult ADHD and how these symptoms affect the clinical presentation of adult patients. A further aim was to assess the impact of ADHD symptoms on quality of life and feelings of disability. METHOD: Participants comprised 89 patients diagnosed with ED according to DSM-5 criteria...
May 2017: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/28593834/salibacter-halophilus-gen-nov-sp-nov-isolated-from-a-saltern
#20
De-Chen Lu, Jun Xia, Christopher A Dunlap, Alejandro P Rooney, Zong-Jun Du
A Gram-stain-negative and facultatively anaerobic bacterium, JZ3C34T, was isolated from a saltern in Feicheng, China (36° 8' 24.45″ E 116° 49' 22.46″ N). Cells of strain JZ3C34T were 0.3-0.4 µm wide and 1.5-2.0 µm long, catalase-positive and oxidase-negative. Colonies on modified marine agar 2216 were orange, circular, convex, translucent and approximately 1 mm in diameter after incubation for 96 h at 33 °C. Growth occurred at 20-50 °C (optimally at 33 °C), at pH 6.5-8.5 (optimally at 7...
June 8, 2017: International Journal of Systematic and Evolutionary Microbiology
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