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Acne vulgaris

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https://www.readbyqxmd.com/read/28228751/prospects-of-phage-application-in-the-treatment-of-acne-caused-by-propionibacterium-acnes
#1
REVIEW
Ewa Jończyk-Matysiak, Beata Weber-Dąbrowska, Maciej Żaczek, Ryszard Międzybrodzki, Sławomir Letkiewicz, Marzanna Łusiak-Szelchowska, Andrzej Górski
Propionibacterium acnes is associated with purulent skin infections, and it poses a global problem for both patients and doctors. Acne vulgaris (acne) remains a problem due to its chronic character and difficulty of treatment, as well as its large impact on patients' quality of life. Due to the chronic course of the disease, treatment is long lasting, and often ineffective. Currently there are data regarding isolation of P. acnes phages, and there have been numerous studies on phage killing of P. acnes, but no data are available on phage application specifically in acne treatment...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28223742/insulin-like-growth-factor-1-increases-the-expression-of-inflammatory-biomarkers-and-sebum-production-in-cultured-sebocytes
#2
Hyojin Kim, Sun Young Moon, Mi Yeung Sohn, Weon Ju Lee
BACKGROUND: Acne vulgaris has been linked to the Western diet. Hyperglycemic diet increases insulin and insulin-like growth factor (IGF)-1. Deeper insights into IGF-1-mediated signal pathway are critical importance to understand the impact of Western diet. OBJECTIVE: We investigated the effect of IGF-1 on the expression of inflammatory biomarkers and sebum production in cultured sebocytes. METHODS: Polymerase chain reaction and enzyme-linked immunosorbent assay were performed to measure changes in the expression of inflammatory biomarkers including interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), IGF1R, IGFBP2, sterol response element-binding protein (SREBP), and phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PI3KCA) after the treatment of cultured sebocytes with 10(-7) M or 10(-5) M IGF-1...
February 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28220628/the-role-of-nicotinamide-in-acne-treatment
#3
REVIEW
Frances M Walocko, Ariel E Eber, Jonette E Keri, Mana A Al-Harbi, Keyvan Nouri
Safe and effective treatment options for acne vulgaris are needed to address side effects and increasing rates of antibiotic resistance from current treatments. Nicotinamide is a vitamin with potent anti-inflammatory properties that could offer a potential treatment option. We aim to summarize the relevant literature on the role of nicotinamide in acne vulgaris and discuss the next steps necessary to move this approach into clinical practice. We searched PubMed for clinical studies using nicotinamide for treatment of acne vulgaris...
February 21, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28218972/views-of-oral-antibiotics-and-advice-seeking-about-acne-a-qualitative-study-of-online-discussion-forums
#4
M Santer, D Chandler, M Lown, N A Francis, I Muller
BACKGROUND: Acne vulgaris is common and can significantly impair quality of life, yet little is known about patients' understanding of acne and its treatments. Oral antibiotics are widely used for acne, despite concerns about antibiotic resistance. People are increasingly turning to online discussion forums for advice and information on these sites may influence health beliefs and treatment adherence. OBJECTIVE: To explore understandings about the use of oral antibiotics for acne and advice shared amongst messages posted on online forums...
February 20, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28218057/propionibacterium-acnes-is-developing-gradual-increase-in-resistance-to-oral-tetracyclines
#5
Keisuke Nakase, Hidemasa Nakaminami, Yuko Takenaka, Nobukazu Hayashi, Makoto Kawashima, Norihisa Noguchi
Propionibacterium acnes is an anaerobic bacterium that causes deep infection in organs and prosthetic joints, in addition to acne vulgaris. Many tetracycline-resistant P. acnes strains have been isolated because oral tetracyclines are frequently used as an acne treatment against P. acnes. In this study, we found a novel tetracycline resistance mechanism in P. acnes. Three doxycycline-resistant (MIC: 16 µg ml-1) strains were isolated from 69 strains in acne patients in Japan between 2010 and 2011. Additionally, six insusceptible strains (MIC: 1-2 µg ml-1) that had reduced susceptibility compared to susceptible strains (MIC: ≤0...
January 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28210380/emerging-issues-in-adult-female-acne
#6
REVIEW
Joshua A Zeichner, Hillary E Baldwin, Fran E Cook-Bolden, Lawrence F Eichenfield, Sheila Fallon-Friedlander, David A Rodriguez
Acne vulgaris (acne) is a common affliction in adolescence and is a growing problem in adult women. Despite an increasing awareness of acne in the adult female population, there is a lack of good prospective studies assessing the severity, distribution, and differential response to treatment in this group. The long-held dogma that acne in adult women develops on the lower one-third of the face has been recently challenged, and here the authors critically review data from available literature. Moreover, while adult female acne has traditionally been defined as disease in women over age 25, it is the authors' experience that this group is subdivided into women ages 25 to 44 years, separate from perimenopausal patients, ages 45 years and up...
January 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28208738/oral-administration-of-the-japanese-traditional-medicine-keishibukuryogan-ka-yokuinin-decreases-reactive-oxygen-metabolites-in-rat-plasma-identification-of-chemical-constituents-contributing-to-antioxidant-activity
#7
Yosuke Matsubara, Takashi Matsumoto, Kyoji Sekiguchi, Junichi Koseki, Atsushi Kaneko, Takuji Yamaguchi, Yumiko Kurihara, Hiroyuki Kobayashi
Insufficient detoxification and/or overproduction of reactive oxygen species (ROS) induce cellular and tissue damage, and generated reactive oxygen metabolites become exacerbating factors of dermatitis. Keishibukuryogan-ka-yokuinin (KBGY) is a traditional Japanese medicine prescribed to treat dermatitis such as acne vulgaris. Our aim was to verify the antioxidant properties of KBGY, and identify its active constituents by blood pharmacokinetic techniques. Chemical constituents were quantified in extracts of KBGY, crude components, and the plasma of rats treated with a single oral administration of KBGY...
February 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28193374/-isotretinoin-therapy-for-acne-vulgaris-and-first-episode-psychosis-in-an-adolescent-patient
#8
Felipe Valderrama, Andrea Gómez, Diana Restrepo
No abstract text is available yet for this article.
January 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/28193081/association-between-acne-and-serum-pro-inflammatory-cytokines-il-1%C3%AE-il-1%C3%AE-il-1ra-il-6-il-8-il-12-and-rantes-in-mustard-gas-exposed-patients-sardasht-iran-cohort-study
#9
Nayere Askari, Tooba Ghazanfari, Roya Yaraee, Mohammad Reza Vaez Mahdavi, Mohammad-Reza Soroush, Zuhair Mohammad Hassan, Zohre Khodashenas, Jalaleddin Shams, Soghrat Faghihzadeh
BACKGROUND: Acne vulgaris is a very common chronic inflammatory disorder, yet its pathogenesis is not clearly understood. As part of the SICS, this study was conducted to evaluate the association between the incidence of acne vulgaris in SM-exposed subjects (20 years after the exposure) and serum levels of proinflammatory cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) in an attempt to better understand the pathogenesis of long-term skin disorders of these individuals...
February 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28191680/friends-or-foes-host-defense-antimicrobial-peptides-and-proteins-in-human-skin-diseases
#10
REVIEW
François Niyonsaba, Chanisa Kiatsurayanon, Panjit Chieosilapatham, Hideoki Ogawa
Host defense peptides/proteins (HDPs), also known as antimicrobial peptides/proteins (AMPs), are key molecules in the cutaneous innate immune system. AMPs/HDPs historically exhibit broad-spectrum killing activity against bacteria, enveloped viruses, fungi and several parasites. Recently, AMPs/HDPs were shown to have important biological functions, including inducing cell proliferation, migration and differentiation; regulating inflammatory responses; controlling the production of various cytokines/chemokines; promoting wound healing; and improving skin barrier function...
February 13, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28168623/a-report-of-two-cases-of-solid-facial-edema-in-acne
#11
Sarah Kuhn-Régnier, Joanna Mangana, Katrin Kerl, Jivko Kamarachev, Lars E French, Antonio Cozzio, Alexander A Navarini
INTRODUCTION: Solid facial edema (SFE) is a rare complication of acne vulgaris. To examine the clinical features of acne patients with solid facial edema, and to give an overview on the outcome of previous topical and systemic treatments in the cases so far published. METHODS: We report two cases from Switzerland, both young men with initially papulopustular acne resistant to topical retinoids. RESULTS: Both cases responded to oral isotretinoin, in one case combined with oral steroids...
February 6, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28163574/acne-vulgaris-perceptions-and-beliefs-of-saudi-adolescent-males
#12
Sahar H Al-Natour
INTRODUCTION: Although acne vulgaris is common in adolescents, information on their understanding of acne is minimal. OBJECTIVES: To evaluate the perceptions and beliefs of Saudi youth on acne. MATERIALS AND METHODS: Three hundred twenty-nine male students (aged 13-22 years) from 6 secondary schools in the Eastern Saudi Arabia completed a self-reported questionnaire on knowledge, causation, exacerbating and relieving factors of acne. Data were analyzed by SPSS version 15...
January 2017: Journal of Family & Community Medicine
https://www.readbyqxmd.com/read/28163455/papular-acne-scars-of-the-nose-and-chin-an-under-recognised-variant-of-acne-scarring
#13
Faisal R Ali, Michael Kirk, Vishal Madan
BACKGROUND: Scarring following acne vulgaris is common and can be of profound psychosocial consequence. AIMS AND OBJECTIVES: We have clinically noted a variant of acne scarring, overlooked by previous categorisation schemes, which we have denominated as papular acne scars of the nose and chin. We sought to characterise these novel entities further. MATERIALS AND METHODS: Initially, we identified 14 patients with papular acne scars of the nose and chin in a cosmetic dermatology clinic, of whom two were female and rest were male...
October 2016: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/28155090/oral-spironolactone-for-acne-vulgaris-in-adult-females-a-hybrid-systematic-review
#14
REVIEW
Alison M Layton, E Anne Eady, Heather Whitehouse, James Q Del Rosso, Zbys Fedorowicz, Esther J van Zuuren
BACKGROUND: The management of acne in adult females is problematic, with many having a history of treatment failure and some having a predisposition to androgen excess. Alternatives to oral antibiotics and combined oral contraceptives (COCs) are required. OBJECTIVE: Our aim was to conduct a hybrid systematic review of the evidence for benefits and potential harms of oral spironolactone in the management of acne in adult females. METHODS: The review was conducted according to a previously published protocol...
February 2, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28150367/open-label-randomized-multicenter-phase-iii-study-to-evaluate-the-safety-and-efficacy-of-benzoyl-peroxide-gel-in-long-term-use-in-patients-with-acne-vulgaris-a-secondary-publication
#15
Makoto Kawashima, Toshitaka Nagare, Tsuneo Katsuramaki
An open-label, randomized, multicenter study was conducted to evaluate the safety and efficacy of long-term use of 2.5% and 5% benzoyl peroxide (BPO) gels administrated once daily for 52 weeks to Japanese patients with acne vulgaris. The efficacy of the study drugs was evaluated by counting inflammatory lesions and non-inflammatory lesions. Safety was evaluated based on adverse events, local skin tolerability scores and laboratory test values. In total, 458 subjects were included in the efficacy and safety analyses...
February 2, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28128074/the-role-of-androgens-and-estrogens-in-hidradenitis-suppurativa-a-systematic-review
#16
REVIEW
Peter Theut Riis, Hans Christian Ring, Lotte Themstrup, Gregor Borut Jemec
Hidradenitis suppurativa (HS) is an inflammatory skin disease. Several observations imply that sex hormones may play a role in its pathogenesis. HS is more common in women, and the disease severity appears to vary in intensity according to the menstrual cycle. In addition, parallels have been drawn between HS and acne vulgaris, suggesting that sex hormones may play a role in the condition. The role of androgens and estrogens in HS has therefore been explored in numerous observational and some interventional studies; however, the studies have often reported conflicting results...
December 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28126936/draft-genome-sequence-of-an-erythromycin-resistant-propionibacterium-acnes-isolate-recovered-from-folliculitis-of-the-scalp
#17
Guillaume Ghislain Aubin, Stanimir Kambarev, Aurélie Guillouzouic, Amir Khammari, Brigitte Dréno, Stéphane Corvec
Propionibacterium acnes is now well-known and recognized for its implication in the pathogenesis of acne vulgaris. Here, we report the draft genome sequence of an erythromycin-resistant P. acnes strain isolated from a case of folliculitis of the scalp belonging to phylotype IA1 and sequence type 18 (ST18).
January 26, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28124400/a-multifactorial-comparison-of-ternary-combinations-of-essential-oils-in-topical-preparations-to-current-antibiotic-prescription-therapies-for-the-control-of-acne-vulgaris-associated-bacteria
#18
Lucy Owen, Martin Grootveld, Randolph Arroo, Victor Ruiz-Rodado, Penny Price, Katie Laird
Acne vulgaris, a chronic condition associated with overgrowth of Propionibacterium acnes and Staphylococcus epidermidis, is commonly treated with antibiotics. However, the emergence of antibiotic resistance has resulted in a need for alternative therapies. The aim of this study is to develop a topical preparation incorporating essential oils (EOs) for use against acne-associated bacteria and assess its efficacy against prescription therapies Dalacin T and Stiemycin. Antimicrobial screening of rosewood, clove bud and litsea EOs was conducted before interactions between binary and ternary combinations were determined against P...
January 26, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28119103/topical-delivery-of-roxithromycin-solid-state-forms-entrapped-in-vesicles
#19
Candice Csongradi, Jeanetta du Plessis, Marique Elizabeth Aucamp, Minja Gerber
Recently, considerable interest developed in using newer/improved antibiotics for the treatment of Acne vulgaris. During this study, different roxithromycin solid-state forms (i.e. crystalline and amorphous) were encapsulated into vesicle systems (niosomes, proniosomes, ufosomes and pro-ufosomes) for dermis targeted delivery. Characterization of the vesicles was done with transmission electron microscopy, light microscopy, droplet size, droplet size distribution, pH, zeta-potential and entrapment efficiency percentage...
January 21, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28117399/treatment-effects-of-lysozyme-shelled-microbubbles-and-ultrasound-in-inflammatory-skin-disease
#20
Ai-Ho Liao, Chi-Ray Hung, Chieh-Fu Lin, Yi-Chun Lin, Hang-Kang Chen
Acne vulgaris is the most common skin disorder, and is caused by Propionibacterium acnes (P. acnes) and can induce inflammation. Antibiotic therapy often needs to be administered for long durations in acne therapy, which results in extensive antibiotic exposure. The present study investigated a new treatment model for evaluating the antibacterial effects of lysozyme (LY)-shelled microbubbles (MBs) and ultrasound (US)-mediated LY-shelled MBs cavitation against P. acnes both in vitro and in vivo, with the aims of reducing the dose and treatment duration and improving the prognosis of acne vulgaris...
January 24, 2017: Scientific Reports
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