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Acne vulgaris

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https://www.readbyqxmd.com/read/28707712/acne-prevalence-and-associations-with-lifestyle-a-cross-sectional-online-survey-of-adolescents-young-adults-in-7-european-countries
#1
P Wolkenstein, A Machovcová, J C Szepietowski, D Tennstedt, S Veraldi, A Delarue
BACKGROUND: Although acne vulgaris is a common skin disorder, limited epidemiological data exist specifically for European populations. OBJECTIVE: To determine the prevalence of self-reported acne among young people in Europe and evaluate the effect of lifestyle on acne. METHODS: We conducted a cross-sectional population-based online survey in representative samples of individuals aged 15-24 years in Belgium, Czech and Slovak Republics, France, Italy, Poland and Spain (n=10,521), identified by a quota sampling method based on age, geographic location, and socio-professional category...
July 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28705050/association-of-isotretinoin-with-depression-and-suicide-a-review-of-current-literature
#2
João Miguel Oliveira, Gonçalo Sobreira, Jorge Velosa, Diogo Telles Correia, Paulo Filipe
Acne vulgaris, a condition that can affect people at any age, is the most common cause of referral to a dermatologist. Isotretinoin (ITT) is the most effective treatment available, but serious adverse effects, including a possible association with depression and suicide, limit its use. We review the current literature regarding the association of ITT with depression and suicide. Case reports and database studies show a clear association, and this association is biologically plausible. Although prospective studies have opposite results, limitations make them unsuitable to identify a subgroup of patients who may be at risk of developing depression or suicidal ideation with ITT...
July 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28704984/the-effect-of-personal-familial-and-enviroinmental-characteristics-on-acne-vulgaris-a-prospective-multicenter-case-controlled-study-from-turkey
#3
Ayşe S Karadağ, İlknur Balta, Hayriye Saricaoğlu, Selim Kiliç, Kıymet H Kelekçi, Mehmet Yildirim, Deniz A Arica, Savaş Öztürk, Göksun Karaman, Aslı A Çerman, Serap G Bilgili, Enver Turan, Mustafa M Demirci, Tuğba K Uzunçakmak, Serdar C Güvenç, Arzu Ataseven, Ayten Ferahbaş, Berna Aksoy, Emine Çölgeçen, Özlem Ekiz, Filiz Topaloğlu Demir, Özlem Bilgiç, Seray Çakmak, Derya Uçmak, Pınar Özuğuz, Yeşim Kaymak Konkuralp, Aylin T Ermertcan, Gonca Gökdemir, Emel Bülbül Başkan, Gökçen Alyamaç, Hatice Şanli
BACKGROUND: There are only a few studies about epidemiological features of acne vulgaris in the literature. The aim of this study was to analyze demographic, clinical, familial and environmental characteristics of acne, the role of diet and aggravating factors and association of these factors with acne severity. METHODS: Patients with a diagnosis of mild-moderate to severe acne were consecutively interviewed at the participating centers during the study period. RESULTS: A total of 3826 patients and 759 control patients were involved in this study...
July 11, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28690124/microneedling-where-do-we-stand-now-a-systematic-review-of-the-literature
#4
REVIEW
Ramaut Lisa, Hoeksema Henk, Pirayesh Ali, Stillaert Filip, Monstrey Stan
BACKGROUND: Patients who suffer from scars or wrinkles have several therapeutic options to improve the appearance of their skin. The available treatment modalities that provide desirable results are often overtly invasive and entail a risk of undesirable adverse effects. Microneedling has recently emerged as a non-ablative alternative for treating patients who are concerned with the aesthetic changes that result from injury, disease or ageing. OBJECTIVE: This review aims to evaluate the current evidence in the literature on microneedling...
June 17, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28686777/treatment-response-with-once-daily-topical-dapsone-gel-7-5-for-acne-vulgaris-subgroup-analysis-of-pooled-data-from-two-randomized-double-blind-stu
#5
Zoe Diana Draelos, David A Rodriguez, Steven E Kempers, Suzanne Bruce, Marina I Peredo, Jeanine Downie, Joan-En Chang-Lin, David R Berk, Shiling Ruan, Alexandre Kaoukhov
<p>BACKGROUND: Acne vulgaris has varying physical and psychological effects in men and women of different ages, races, and ethnicities.</p> <p>OBJECTIVE: This analysis assessed the relationship of age, sex, and race to treatment response with once-daily topical dapsone gel, 7.5%.</p> <p>METHODS: We conducted a pooled subgroup analysis of 2 randomized, double-blind, vehicle-controlled clinical trials conducted in the US and Canada. The studies included patients with 20 to 50 inflammatory and 30 to 100 noninflammatory facial lesions, and a Global Acne Assessment Score (GAAS) of 3 (moderate)...
June 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28686776/adapalene-benzoyl-peroxide-gel-0-3-2-5-effective-acne-therapy-regardless-of-age-or-gender
#6
Linda Stein Gold, William P Werschler, Jennifer Mohawk
<p>BACKGROUND: Acne vulgaris affects a diverse group of people, and there is an increasingly wide variety of acne treatments. Because of the many options, clinicians have a better ability to individualize treatment; however, achieving optimal results relies on understanding how various agents perform in specific population segments. Fixed-combination adapalene plus benzoyl peroxide (A/BPO) is a first-line recommended acne therapy and is available in two adapalene concentrations (0.1% and 0.3%) combined with BPO 2...
June 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28686771/fixed-combination-of-clindamycin-phosphate-1-2-and-benzoyl-peroxide-3-75-aqueous-gel-long-term-use-in-adult-females-with-moderate-acne-vulgaris
#7
Leon H Kircik
<p>OBJECTIVE: To evaluate long-term efficacy and safety of a fixed combination clindamycin phosphate 1.2% and benzoyl peroxide 3.75% (Clindamycin-BP 3.75%) aqueous gel in adult female patients with moderate acne vulgaris.</p> <p>METHODS: Total of 20 patients, 25-63 years of age (mean [SD], 38 ± 10) with moderate acne (IGA=3) were treated with Clindamycin-BP 3.75% once-daily for 12 weeks. Patients who experienced ≥50% reduction in total lesion count continued treatment for a further 12 weeks...
June 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28686770/the-efficacy-and-safety-of-azelaic-acid-15-foam-in-the-treatment-of-truncal-acne-vulgaris
#8
Lauren K Hoffman, James Q Del Rosso, Leon H Kircik
<p>INTRODUCTION: Truncal acne is often associated with facial acne, but there are fewer options for an effective topical treatment on the trunk. Given the advent of foam formulations with enhanced percutaneous absorption and convenient application due to easy spreadability on skin, the previously held idea that effective treatment of truncal acne requires oral treatment is challenged. Azelaic acid cream has been previously approved for acne vulgaris, thus azelaic acid foam may be a viable treatment option for truncal acne...
June 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28671431/acne-vulgaris-treatment-guidelines-from-the-aad
#9
Lisa Hauk
No abstract text is available yet for this article.
June 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28670354/psychosocial-impact-of-postinflammatory-hyperpigmentation-in-patients-with-acne-vulgaris
#10
Kavita Darji, Reena Varade, Daniel West, Eric S Armbrecht, Mary A Guo
Background: Acne vulgaris is a common, often socially distressing skin condition primarily seen in young adults. Quality of life studies have shown that people with acne are more introverted with increased social setting anxiety compared to a control group. Unfortunately, patients with acne may have residual postinflammatory hyperpigmentation, amplifying impaired psychosocial effects. Objective: To quantify the impact of postinflammatory hyperpigmentation in patients with acne using a psychometric scale. Design: A clinic-based survey was conducted among US adults with facial acne and postinflammatory hyperpigmentation...
May 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28647025/olumacostat-glasaretil-a-promising-topical-sebum-suppressing-agent-that-affects-all-major-pathogenic-factors-of-acne-vulgaris
#11
Bodo C Melnik
Hunt et al. show that olumacostat glasaretil, an inhibitor of acetyl coenzyme A carboxylase, reduces saturated and monounsaturated fatty acyl chains in sebaceous lipids. Topical olumacostat glasaretil application decreases hamster ear sebaceous gland size and shows efficacy in treating patients with acne vulgaris. Olumacostat glasaretil-mediated sebum suppression may reduce Propionibacterium acnes growth and biofilm formation, comedogenesis, and inflammation.
July 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28636791/isotretinoin-and-lymecycline-treatments-modify-the-skin-microbiota-in-acne
#12
Hanna-Leena Kelhälä, Velma T E Aho, Nanna Fyhrquist, Pedro A B Pereira, Minna E Kubin, Lars Paulin, Riitta Palatsi, Petri Auvinen, Kaisa Tasanen, Antti Lauerma
Oral retinoids and tetracyclines have a major role in acne treatment. Here, we report for the first time the effect of isotretinoin and lymecycline therapy on the skin microbiota in cheek, back and armpit swab samples of acne vulgaris patients using 16S ribosomal RNA (16S rRNA) gene amplicon sequencing. Propionibacterium acnes was the most common in sebaceous areas of healthy and untreated acne skin and more abundant in back than cheek samples. Five taxa, including a Streptococcus taxon, differed significantly between the cheek samples of healthy controls and acne patients, and acne severity was positively correlated with the abundance of Propionibacterium...
June 21, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28631890/oxidative-stress-and-psychiatric-morbidity-in-patients-with-facial-acne
#13
Sara M Awad, Hanan Morsy, Ayat A Sayed, Nahed A Mohamed, Ghada M Ezzat, Mostafa M Noaman
BACKGROUND: Acne vulgaris is a common cosmetic problem that is frequently associated with psychosocial disturbances as well as increased oxidative stress. However, oxidative stress and psychological aspects have been studied separately in acne. OBJECTIVE: To evaluate the relationships between oxidative stress, anxiety, depression, and quality of life in acne patients. METHODS: Sixty patients with facial acne and 40 age- and sex-matched healthy individuals were included in the study...
June 20, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28623918/effects-of-herbal-medicine-for-dysmenorrhea-treatment-on-accompanied-acne-vulgaris-a-study-protocol-for-a-randomized-controlled-trial
#14
Kwan-Il Kim, Hae Jeong Nam, Mia Kim, Junhee Lee, Kyuseok Kim
BACKGROUND: The incidence of preadolescent acne among women is increasing. Acne deteriorates the quality of life; conventional treatment options are limited and have not been effective against acne, particularly acne associated with menstruation. Despite evidence that acne associated with menstruation abnormalities naturally improves when menstruation recovers to normal, there have only been few studies on the effects of dysmenorrhea treatment on acne. Therefore- we designed this study to assess the effects of gyejibokryung-hwan (GBH) and dangguijagyag-san (DJS), which are widely used in dysmenorrhea treatment, on acne associated with menstruation cycle...
June 17, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28619551/evidence-based-recommendations-for-the-management-of-acne-fulminans-and-its-variants
#15
REVIEW
Tanya Greywal, Andrea L Zaenglein, Hilary E Baldwin, Neal Bhatia, Karen A Chernoff, James Q Del Rosso, Lawrence F Eichenfield, Marc H Levin, James J Leyden, Diane M Thiboutot, Guy F Webster, Sheila Fallon Friedlander
BACKGROUND: Acne fulminans (AF) is a severe variant of inflammatory acne. It typically manifests as an explosive worsening and ulceration of skin lesions, and can be associated with systemic symptoms. However, there is a paucity of evidence-based information and no clear guidelines concerning the classification and treatment of AF. OBJECTIVE: To better define the spectrum of AF and its variants, devise optimal therapeutic approaches, and identify areas of future research...
July 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28609760/epidemiology-of-acne-vulgaris-in-18-year-old-male-army-conscripts-in-a-south-brazilian-city
#16
Rodrigo Pereira Duquia, Iná da Silva Dos Santos, Hiram de Almeida, Paulo Ricardo Martins Souza, Juliano de Avelar Breunig, Christos C Zouboulis
BACKGROUND: Prevalence of acne varies worldwide. Several factors (age, skin color, body fat, diet, and smoking) have been investigated as risk factors. OBJECTIVE: A total of 2,201 18-year-old males living in Pelotas, South Brazil, were evaluated in order to examine the prevalence of acne and associated factors. METHODS: A cross-sectional population-based study was conducted. A dermatologist performed the clinical examination of the face and trunk for identification of acne lesions...
June 14, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28605136/a-polycation-antimicrobial-peptide-mimic-without-resistance-buildup-against-propionibacterium-acnes
#17
Sithara S Nair, Olga Y Zolotarskaya, Matthew J Beckwith, Dennis E Ohman, Kenneth J Wynne
A preliminary study is reported for a polycation antimicrobial peptide (AMP) mimic against Propionibacterium acnes, which is associated with acne vulgaris, a common skin condition. Antibiotics are commonly used against P. acnes but buildup of resistance is well-known. Worse, antibiotic regimens build up resistance for more sensitive bacteria such as Staphylococcus epidermidis. The polycation AMP mimic C12-50, 1, is chosen for the present study as it has been previously shown to have high antimicrobial effectiveness...
June 12, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28603018/mechanistic-analysis-of-human-skin-distribution-and-follicular-targeting-of-adapalene-loaded-biodegradable-nanospheres-with-an-insight-into-hydrogel-matrix-influence-in-vitro-skin-irritation-and-in-vivo-tolerability
#18
Marwa Ahmed Sallam, M Teresa Marín Boscá
This work aimed at the development of a biocompatible, non-oily nanomedicine for follicular delivery of adapalene (AD) ameliorating its irritation potential for convenient localized topical treatment of acne vulgaris. AD was efficiently incorporated into poly-Ԑ-caprolactone nanospheres (NS) with an encapsulation efficiency of (84.73± 1.52%), a particle size of (107.5± 8.19 nm), and zeta potential of -13.1 mV demonstrating a sustained release behavior. The AD-NS were embedded in either HPMC or hyaluronate gel (HA)...
June 8, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28601424/a-diagnostic-approach-to-recurrent-orofacial-swelling-a-retrospective-study-of-104-patients
#19
Rachel Y Miest, Alison J Bruce, Nneka I Comfere, Elena Hadjicharalambous, Dawnielle Endly, Christine M Lohse, Roy S Rogers
OBJECTIVE: To identify patients evaluated in an outpatient setting at our institution with a presentation of recurrent orofacial swelling and to review the spectrum of causes to outline a diagnostic approach. PATIENTS AND METHODS: A retrospective study of 104 patients with more than 1 episode of orofacial swelling lasting for more than 5 days identified through a keyword search of the electronic health record from January 2, 2000, through July 5, 2011. RESULTS: Patients were categorized according to final cause of orofacial swelling: idiopathic orofacial granulomatosis, solid facial edema due to rosacea and acne vulgaris, Crohn disease, contact dermatitis, sarcoidosis, exfoliative cheilitis, lichen planus, actinic cheilitis, cheilitis glandularis, lymphedema, miscellaneous, and multifactorial...
July 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28594356/synergistic-antibacterial-effects-of-chitosan-caffeic-acid-conjugate-against-antibiotic-resistant-acne-related-bacteria
#20
Ji-Hoon Kim, Daeung Yu, Sung-Hwan Eom, Song-Hee Kim, Junghwan Oh, Won-Kyo Jung, Young-Mog Kim
The object of this study was to discover an alternative therapeutic agent with fewer side effects against acne vulgaris, one of the most common skin diseases. Acne vulgaris is often associated with acne-related bacteria such as Propionibacteriumacnes, Staphylococcusepidermidis, Staphylococcusaureus, and Pseudomonasaeruginosa. Some of these bacteria exhibit a resistance against commercial antibiotics that have been used in the treatment of acne vulgaris (tetracycline, erythromycin, and lincomycin). In the current study, we tested in vitro antibacterial effect of chitosan-phytochemical conjugates on acne-related bacteria...
June 8, 2017: Marine Drugs
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