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Acne vulgaris

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https://www.readbyqxmd.com/read/29164826/comparative-study-of-buffered-50-glycolic-acid-ph-3-0-0-5-salicylic-acid-solution-vs-jessner-s-solution-in-patients-with-acne-vulgaris
#1
Jeong In Jae, Hyun Dong Ju, Kim Dong Hyun, Moon Soo Yoon, Hee Jung Lee
BACKGROUND: Superficial chemical peels are frequently used in acne vulgaris treatment. Although glycolic acid (GA) has been widely used in clinical practice, its pH ranges from 0.08-2.75 and thus should be neutralized after application to avoid burns. OBJECTIVE: To evaluate treatment efficacy and safety of chemical peeling using buffered 50% GA (pH 3.0) + 0.5% salicylic acid (SA) solution that does not need to be neutralized in the treatment of acne vulgaris compared to the conventional peeling using Jessner's solution...
November 21, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29159884/serum-homocysteine-levels-in-acne-patients
#2
Hao Jiang, Changyi Li, Bin Wei, Qiang Wang, Jiang Zhong, Jianqi Lu
OBJECTIVE: This study was designed to investigate serum homocysteine (HCY) levels in acne patients. METHODS: Acne patients (n = 124) and healthy volunteers (n = 70), matched in terms of both age and sex, were enrolled. Serum HCY levels for all subjects were measured by a clinical laboratory. RESULTS: Serum HCY levels in male and female patients with severe and moderate acne were significantly higher than in the healthy control group (P < ...
November 21, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29154071/clinical-effects-of-zingiber-cassumunar-plai-a-systematic-review
#3
Bunchai Chongmelaxme, Rosarin Sruamsiri, Piyameth Dilokthornsakul, Teerapon Dhippayom, Chuenjid Kongkaew, Surasak Saokaew, Anchalee Chuthaputti, Nathorn Chaiyakunapruk
Zingiber cassumunar Roxb. known locally as "Plai" in Thai, has been used for treating bruise, sprain and musculoskeletal pain. Several pre-clinical studies demonstrated the anti-inflammatory effect of Plai. However, current evidence of clinical effects of Plai is still unclear. This study aimed to determine the clinical efficacy and safety of Plai among all identified indications. Of the 808 articles identified by a systematic review, six studies were included. Four studies were randomized controlled trials, while two studies were quasi-experimental studies involving 178 patients in intervention group and 177 patients in control group...
December 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29152718/an-extension-of-a-multicenter-randomized-split-face-clinical-trial-evaluating-the-efficacy-and-safety-of-chromophore-gel-assisted-blue-light-phototherapy-for-the-treatment-of-acne
#4
Andreas Nikolis, Stéphane Fauverghe, Giovanni Scapagnini, Dimitrios Sotiriadis, George Kontochristopoulos, Athanasios Petridis, Dimitrios Rigopoulos, Clio Dessinioti, Konstantinos Kalokasidis, Christina Antoniou
A variety of laser/light-based devices have been reported to be effective for the treatment of acne, yet no long-term data on efficacy and safety have been published. A first 12-week clinical trial ("Main trial") recently demonstrated that the KLOX BioPhotonic System, an LED blue light device using photo-converter chromophores, can significantly improve moderate and severe facial acne vulgaris with an excellent safety profile. This Extension trial followed the Main trial, using the same BioPhotonic System, with the same dose and instructions for use, on patients having already completed treatment in the Main trial...
November 20, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29148415/exacerbation-of-beh%C3%A3-et-s-syndrome-and-familial-mediterranean-fever-with-menstruation
#5
Gul Guzelant, Yesim Ozguler, Sinem Nihal Esatoglu, Guzin Karatemiz, Huri Ozdogan, Sebahattin Yurdakul, Hasan Yazici, Emire Seyahi
OBECTIVES: Menstruation triggers several conditions such as migraine, recurrent aphthous stomatitis and acne vulgaris in healthy individuals. There is evidence that Behçet's syndrome (BS) and familial Mediterranean fever (FMF) may exacerbate during menstruation. The aim is to assess whether BS and FMF patients experience menstrual flares. METHODS: Females of reproductive age with BS and FMF seen consecutively at the outpatient clinic of Cerrahpasa Medical Faculty at Istanbul, as well as apparently healthy hospital workers were studied using a standardised questionnaire...
October 24, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29141062/management-of-severe-acne-vulgaris-with-topical-therapy
#6
Linda Stein Gold, Hilary E Baldwin, Tina Lin
<p>Acne vulgaris (acne) is the most common skin disease we see in dermatology practice. Although rare in childhood, severe acne can affect up to 12% of the adolescent population. A chronic disease, it requires both aggressive management and effective maintenance strategies. Oral antibiotics, in combination with topical agents are recommended for treatment, with topical agents being continued as maintenance therapy to minimize resistance and recurrence. However, concerns with systemic side effects have recently resulted in a greater focus on the potential of fixed combination topical therapies to treat severe acne...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29141057/lasers-light-and-the-treatment-of-acne-a-comprehensive-review-of-the-literature
#7
Lana X Tong, Jeremy A Brauer
INTRODUCTION: Acne vulgaris is common dermatologic condition with an estimated prevalence of 70 to 87%. Acne has been shown to have a significant impact on patient quality of life and mental health, especially as inflammatory lesions typically occur on cosmetically sensitive areas with the potential for permanent scarring. There have been numerous advances in the treatment of inflammatory acne with light-based and laser devices. OBJECTIVE: To review the current evidence for light-based and laser treatments in the management of inflammatory acne...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29138059/pityrosporum-folliculitis-a-retrospective-review-of-110-cases
#8
Brea Prindaville, Leah Belazarian, Nikki A Levin, Karen Wiss
BACKGROUND: Pityrosporum folliculitis is an under-recognized eruption of the face and upper trunk that may be confused with, or occur simultaneously with, acne vulgaris. OBJECTIVE: We sought to characterize risk factors for Pityrosporum folliculitis, its clinical presentation, and response to treatment. METHODS: A retrospective chart review was performed on all patients aged 0 to 21 years seen from 2010-2015 with Pityrosporum folliculitis confirmed by potassium hydroxide (KOH) preparation...
November 11, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29137347/antiandrogenic-and-antimineralocorticoid-health-benefits-of-coc-containing-newer-progestogens-dienogest-and-drospirenone
#9
REVIEW
Pedro-Antonio Regidor, Adolf E Schindler
Data have demonstrated that COCs, besides offering a satisfactory and safe contraception, offer a variety of non-contraceptive health benefits and therapeutic positive aspects. Many prescribes and users, however, do not realize these positive aspects especially the non-contraceptive health benefits. While the contraceptive use is the primary indication for COC use for most women, these users should be advised in regard of the non-contraceptive benefits when contraception is discussed and prescribed. Using COCs specifically for non-contraceptive indications is an off-label use in many clinical situations (only some exceptions as e...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137071/a-comparative-study-of-biological-and-metabolic-biomarkers-between-healthy-individuals-and-patients-with-acne-vulgaris-a-cross-sectional-study-protocol
#10
Kyuseok Kim, Injin Ha, Eunok Kim, Kyunglee Kim
Acne is a multifactorial dermatosis, which is influenced not only by hormones but also by the biochemical relationship between them and the pilosebaceous unit. Inflammatory cytokines, chemokines, active oxygen, and zinc are known to be associated with the development of acne. Further, steroid metabolism is known as one of the important factors related to sebum secretion and comedone formation in acne. However, there is a lack of studies comparing these human biomarkers between healthy individuals and patients with acne...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29131371/utility-of-gram-staining-for-diagnosis-of-malassezia-folliculitis
#11
Wei-Ting Tu, Szu-Ying Chin, Chia-Lun Chou, Che-Yuan Hsu, Yu-Tsung Chen, Donald Liu, Woan-Ruoh Lee, Yi-Hsien Shih
Malassezia folliculitis (MalF) mimics acne vulgaris and bacterial folliculitis in clinical presentations. The role of Gram staining in rapid diagnosis of MalF has not been well studied. In our study, 32 patients were included to investigate the utility of Gram staining for MalF diagnosis. The final diagnoses of MalF were determined according to clinical presentation, pathological result and treatment response to antifungal agents. Our results show that the sensitivity and specificity of Gram staining are 84...
November 13, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29131127/pleiotropic-effects-of-white-willow-bark-and-1-2-decanediol-on-human-adult-keratinocytes
#12
Eleonora Bassino, Franco Gasparri, Luca Munaron
BACKGROUND: Acne vulgaris is a common skin defect, usually occurring during adolescence, but often it can persist in adults leaving permanent face scarring. Acne is usually treated with topical drugs, oral antibiotics, retinoids, and hormonal therapies, but medicinal plants are increasingly employed. OBJECTIVE: To investigate the protective role of white willow bark (WWB) and 1,2-decanediol (DD) on the damage caused by lipopolysaccharides (LPS) on human adult keratinocytes (HaCaT)...
November 8, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29125405/cutibacterium-formerly-propionibacterium-acnes-infections-associated-with-implantable-devices
#13
Amal A Gharamti, Zeina A Kanafani
Cutibacterium acnes (C. acnes), a Gram-positive biofilm-forming rod implicated in acne vulgaris, is increasingly recognized for its role in implant-associated infections. The diagnosis of C. acnes implant-associated infections remains challenging. The optimal treatment is a combination of both surgical intervention and antibiotic therapy. Areas Covered: In this review, we discuss the different types of implant-associated infections caused by C. acnes. We also highlight the clinical manifestations pertaining to the various sites of infection, and identify several risk factors previously reported in the literature...
November 10, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29120856/ppar%C3%AE-pro12ala-and-c161t-polymorphisms-in-patients-with-acne-vulgaris-contribution-to-lipid-and-lipoprotein-profile
#14
Shohreh Saeidi, Foroogh Chamaie-Nejad, Ali Ebrahimi, Fariba Najafi, Ziba Rahimi, Asad Vaisi-Raygani, Ebrahim Shakiba, Zohreh Rahimi
PURPOSE: The aim of present study was to clarify the role of peroxisome proliferator-activated receptor γ (PPARγ) Pro12Ala and C161T variants in the pathogenesis of acne vulgaris (AV) and their influence on lipid and lipoprotein profile. METHODS: The present case-control study consisted of 393 individuals including 198 patients with AV (mild-, moderate-, and severe-AV) and 195 unrelated age-matched healthy individuals from Western Iran. The PPARγ Pro12Ala and C161T polymorphisms were identified using polymerase chain reaction-restriction length polymorphism method...
November 6, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29110752/heritability-and-gwas-analyses-of-acne-in-australian-adolescent-twins
#15
Angela Mina-Vargas, Lucía Colodro-Conde, Katrina Grasby, Gu Zhu, Scott Gordon, Sarah E Medland, Nicholas G Martin
Acne vulgaris is a skin disease with a multifactorial and complex pathology. While several twin studies have estimated that acne has a heritability of up to 80%, the genomic elements responsible for the origin and pathology of acne are still undiscovered. Here we performed a twin-based structural equation model, using available data on acne severity for an Australian sample of 4,491 twins and their siblings aged from 10 to 24. This study extends by a factor of 3 an earlier analysis of the genetic factors of acne...
November 7, 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/29108811/the-antimicrobial-effect-of-cen1hc-br-against-propionibacterium-acnes-and-its-therapeutic-and-anti-inflammatory-effects-on-acne-vulgaris
#16
Rui Han, Hans-Matti Blencke, Hao Cheng, Chun Li
Propionibacterium acnes is a commensal bacterium, which is involved in acne inflammation. An antimicrobial peptide named CEN1HC-Br, which was isolated and characterized form the green sea urchin, has been shown to possess broad-spectrum antibacterial activity. Little is known concerning the potential effects of its antibacterial and anti-inflammatory properties against P. acnes. To examine the potency of CEN1HC-Br in acne treatment, we conducted experiments to analyze the antibacterial and anti-inflammatory activities of CEN1HC-Br both in vitro and in vivo...
November 3, 2017: Peptides
https://www.readbyqxmd.com/read/29104722/skin-surface-ph-in-acne-vulgaris-insights-from-an-observational-study-and-review-of-the-literature
#17
Chaitra Prakash, Puneet Bhargava, Siddhi Tiwari, Banashree Majumdar, Rishi Kumar Bhargava
OBJECTIVE: Recurrent and chronic course of acne vulgaris, despite effect-proven therapies, point to an underfocused aspect in its pathogenesis and management. This study aims to assess in subjects with and without acne, the skin surface pH, a parameter that cumulatively represents functioning of various units of skin, including the barrier. METHODS: A total of 200 patients with acne and 200 age- and sex-matched controls were included. Under basal conditions, facial skin pH was derived from five sites using a skin pH-meter...
July 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29100929/in-vitro-evaluation-of-marine-derived-fungi-against-cutibacterium-acnes
#18
Shivankar Agrawal, Alok Adholeya, Colin J Barrow, Sunil Kumar Deshmukh
Cutibacterium acnes (or Propionibacterium acnes) is the main target for the prevention and medical treatment of acne vulgaris. The aim of this study was to evaluate the in vitro anti-C. acnes and anti-S. epidermidis properties of some marine fungi isolated from different Indian marine environments. Seventy fungal isolates were obtained from samples collected from the west coasts and Andaman Island, India. Methanol extracts of 35 isolates were screened for their antibacterial properties and 5 out of the 35 isolates displayed significant inhibition as compared with tetracycline...
November 10, 2017: Anaerobe
https://www.readbyqxmd.com/read/29095531/low-level-red-led-light-inhibits-hyperkeratinization-and-inflammation-induced-by-unsaturated-fatty-acid-in-an-in-vitro-model-mimicking-acne
#19
Wen-Hwa Li, Ali Fassih, Curt Binner, Ramine Parsa, Michael D Southall
BACKGROUND AND OBJECTIVE: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous units (PSU), associated with increased sebum production, abnormal follicular keratinization (hyperkeratinization), follicular overgrowth of Propionibacterium acnes (P. acnes), and increased inflammatory mediator release. Light therapy has attracted medical interests as a safe alternative treatment for acne. Both blue and red light therapies at high doses >10 J/cm(2) have demonstrated marked effects on inflammatory acne lesions...
November 2, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29084194/-diet-in-pathogenesis-of-acne-vulgaris
#20
REVIEW
Katarzyna Ozdarska, Karolina Osucha, Stepan Savitskyi, Jacek Malejczyk, Ryszard Galus
Acne vulgaris is one of the most common dermatologic condition especially among adolescents. Acne is related to excess sebum production by sebaceous glands, inflammation both within and adjacent to the comedones, hyperproliferation of Propionibacterium acnes. Some of investigations show association between acne and diet. Milk increases the level of IGF-1 leading to the synthesis of androgen-mediated increases sebum production. Chocolate predispose to hyperglycemia and insulinemia which aggravate of acne vulgaris...
October 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
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