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Acne vulgaris

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https://www.readbyqxmd.com/read/28636791/isotretinoin-and-lymecycline-treatments-modify-the-skin-microbiota-in-acne
#1
Hanna-Leena Kelhälä, Velma T E Aho, Nanna Fyhrquist, Pedro A B Pereira, Minna E Kubin, Lars Paulin, Riitta Palatsi, Petri Auvinen, Kaisa Tasanen, Antti Lauerma
Oral retinoids and tetracyclines have a major role in acne treatment. Here, we report for the first time the effect of isotretinoin and lymecycline therapy on the skin microbiota in cheek, back and armpit swab samples of acne vulgaris patients using 16S ribosomal RNA (16S rRNA) gene amplicon sequencing. Propionibacterium acnes was the most common in sebaceous areas of healthy and untreated acne skin and more abundant in back than cheek samples. Five taxa, including a Streptococcus taxon, differed significantly between the cheek samples of healthy controls and acne patients, and acne severity was positively correlated with the abundance of Propionibacterium...
June 21, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28631890/oxidative-stress-and-psychiatric-morbidity-in-patients-with-facial-acne
#2
Sara M Awad, Hanan Morsy, Ayat A Sayed, Nahed A Mohamed, Ghada M Ezzat, Mostafa M Noaman
BACKGROUND: Acne vulgaris is a common cosmetic problem that is frequently associated with psychosocial disturbances as well as increased oxidative stress. However, oxidative stress and psychological aspects have been studied separately in acne. OBJECTIVE: To evaluate the relationships between oxidative stress, anxiety, depression, and quality of life in acne patients. METHODS: Sixty patients with facial acne and 40 age- and sex-matched healthy individuals were included in the study...
June 20, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28623918/effects-of-herbal-medicine-for-dysmenorrhea-treatment-on-accompanied-acne-vulgaris-a-study-protocol-for-a-randomized-controlled-trial
#3
Kwan-Il Kim, Hae Jeong Nam, Mia Kim, Junhee Lee, Kyuseok Kim
BACKGROUND: The incidence of preadolescent acne among women is increasing. Acne deteriorates the quality of life; conventional treatment options are limited and have not been effective against acne, particularly acne associated with menstruation. Despite evidence that acne associated with menstruation abnormalities naturally improves when menstruation recovers to normal, there have only been few studies on the effects of dysmenorrhea treatment on acne. Therefore- we designed this study to assess the effects of gyejibokryung-hwan (GBH) and dangguijagyag-san (DJS), which are widely used in dysmenorrhea treatment, on acne associated with menstruation cycle...
June 17, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28619551/evidence-based-recommendations-for-the-management-of-acne-fulminans-and-its-variants
#4
Tanya Greywal, Andrea L Zaenglein, Hilary E Baldwin, Neal Bhatia, Karen A Chernoff, James Q Del Rosso, Lawrence F Eichenfield, Marc H Levin, James J Leyden, Diane M Thiboutot, Guy F Webster, Sheila Fallon Friedlander
BACKGROUND: Acne fulminans (AF) is a severe variant of inflammatory acne. It typically manifests as an explosive worsening and ulceration of skin lesions, and can be associated with systemic symptoms. However, there is a paucity of evidence-based information and no clear guidelines concerning the classification and treatment of AF. OBJECTIVE: To better define the spectrum of AF and its variants, devise optimal therapeutic approaches, and identify areas of future research...
July 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28609760/epidemiology-of-acne-vulgaris-in-18-year-old-male-army-conscripts-in-a-south-brazilian-city
#5
Rodrigo Pereira Duquia, Iná da Silva Dos Santos, Hiram de Almeida, Paulo Ricardo Martins Souza, Juliano de Avelar Breunig, Christos C Zouboulis
BACKGROUND: Prevalence of acne varies worldwide. Several factors (age, skin color, body fat, diet, and smoking) have been investigated as risk factors. OBJECTIVE: A total of 2,201 18-year-old males living in Pelotas, South Brazil, were evaluated in order to examine the prevalence of acne and associated factors. METHODS: A cross-sectional population-based study was conducted. A dermatologist performed the clinical examination of the face and trunk for identification of acne lesions...
June 14, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28605136/a-polycation-antimicrobial-peptide-mimic-without-resistance-buildup-against-propionibacterium-acnes
#6
Sithara S Nair, Olga Y Zolotarskaya, Matthew J Beckwith, Dennis E Ohman, Kenneth J Wynne
A preliminary study is reported for a polycation antimicrobial peptide (AMP) mimic against Propionibacterium acnes, which is associated with acne vulgaris, a common skin condition. Antibiotics are commonly used against P. acnes but buildup of resistance is well-known. Worse, antibiotic regimens build up resistance for more sensitive bacteria such as Staphylococcus epidermidis. The polycation AMP mimic C12-50, 1, is chosen for the present study as it has been previously shown to have high antimicrobial effectiveness...
June 12, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28603018/mechanistic-analysis-of-human-skin-distribution-and-follicular-targeting-of-adapalene-loaded-biodegradable-nanospheres-with-an-insight-into-hydrogel-matrix-influence-in-vitro-skin-irritation-and-in-vivo-tolerability
#7
Marwa Ahmed Sallam, M Teresa Marín Boscá
This work aimed at the development of a biocompatible, non-oily nanomedicine for follicular delivery of adapalene (AD) ameliorating its irritation potential for convenient localized topical treatment of acne vulgaris. AD was efficiently incorporated into poly-Ԑ-caprolactone nanospheres (NS) with an encapsulation efficiency of (84.73± 1.52%), a particle size of (107.5± 8.19 nm), and zeta potential of -13.1 mV demonstrating a sustained release behavior. The AD-NS were embedded in either HPMC or hyaluronate gel (HA)...
June 8, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28601424/a-diagnostic-approach-to-recurrent-orofacial-swelling-a-retrospective-study-of-104-patients
#8
Rachel Y Miest, Alison J Bruce, Nneka I Comfere, Elena Hadjicharalambous, Dawnielle Endly, Christine M Lohse, Roy S Rogers
OBJECTIVE: To identify patients evaluated in an outpatient setting at our institution with a presentation of recurrent orofacial swelling and to review the spectrum of causes to outline a diagnostic approach. PATIENTS AND METHODS: A retrospective study of 104 patients with more than 1 episode of orofacial swelling lasting for more than 5 days identified through a keyword search of the electronic health record from January 2, 2000, through July 5, 2011. RESULTS: Patients were categorized according to final cause of orofacial swelling: idiopathic orofacial granulomatosis, solid facial edema due to rosacea and acne vulgaris, Crohn disease, contact dermatitis, sarcoidosis, exfoliative cheilitis, lichen planus, actinic cheilitis, cheilitis glandularis, lymphedema, miscellaneous, and multifactorial...
June 7, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28594356/synergistic-antibacterial-effects-of-chitosan-caffeic-acid-conjugate-against-antibiotic-resistant-acne-related-bacteria
#9
Ji-Hoon Kim, Daeung Yu, Sung-Hwan Eom, Song-Hee Kim, Junghwan Oh, Won-Kyo Jung, Young-Mog Kim
The object of this study was to discover an alternative therapeutic agent with fewer side effects against acne vulgaris, one of the most common skin diseases. Acne vulgaris is often associated with acne-related bacteria such as Propionibacteriumacnes, Staphylococcusepidermidis, Staphylococcusaureus, and Pseudomonasaeruginosa. Some of these bacteria exhibit a resistance against commercial antibiotics that have been used in the treatment of acne vulgaris (tetracycline, erythromycin, and lincomycin). In the current study, we tested in vitro antibacterial effect of chitosan-phytochemical conjugates on acne-related bacteria...
June 8, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28593717/genetic-architecture-of-acne-vulgaris
#10
REVIEW
Ramtin Lichtenberger, Michael A Simpson, Catherine Smith, Jonathan Barker, Alexander A Navarini
BACKGROUND: Acne vulgaris is a ubiquitary skin disease characterized by chronic inflammation of the pilosebaceous unit resulting from bacterial colonization of hair follicles by Propionibacterium acnes, androgen-induced increased sebum production, altered keratinization and inflammation. OBJECTIVE: Here we review our current understanding of the genetic architecture of this intriguing disease and want to show rare and corresponding diseases like PCOS with acne vulgaris...
June 7, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28588486/potential-of-il-1-il-18-and-inflammasome-inhibition-for-the-treatment-of-inflammatory-skin-diseases
#11
REVIEW
Gabriele Fenini, Emmanuel Contassot, Lars E French
In 2002, intracellular protein complexes known as the inflammasomes were discovered and were shown to have a crucial role in the sensing of intracellular pathogen- and danger-associated molecular patterns (PAMPs and DAMPs). Activation of the inflammasomes results in the processing and subsequent secretion of the pro-inflammatory cytokines IL-1β and IL-18. Several autoinflammatory disorders such as cryopyrin-associated periodic syndromes and Familial Mediterranean Fever have been associated with mutations of genes encoding inflammasome components...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28567492/in-vitro-modeling-of-unsaturated-free-fatty-acid-mediated-tissue-impairments-seen-in-acne-lesions
#12
Wen-Hwa Li, Qihong Zhang, Carol R Flach, Richard Mendelsohn, Michael D Southall, Ramine Parsa
Acne vulgaris is a disease of pilosebaceous units with multifactorial pathogenesis, including hyperkeratinization, increased sebum secretion, and inflammation. Recently, it was suggested that acne subjects may have also impaired skin barrier. We hypothesized that excess unsaturated free fatty acids (UFFA) present in the sebum may cause barrier impairment associated with increased follicular stratum corneum (SC) thickening and inflammation seen in acne. Therefore, epidermal and sebaceous lipid profiles from acne and healthy subjects were analyzed and an in vitro epidermal tissue model was developed to validate this hypothesis...
May 31, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28562419/endocrine-disorders-and-hormonal-therapy-for-adolescent-acne
#13
Henry L Nguyen, Megha M Tollefson
PURPOSE OF REVIEW: Acne vulgaris is a global disease with increasing prevalence in adolescents. It has a profound impact on their quality of life, especially when endocrine disorders are also involved. Recent concerns regarding antibiotic stewardship, failures with antibiotic usage, and the development of antibiotic-resistant Propionibacterium acnes have led clinicians to consider other therapeutic options for acne treatment. The present review explores hormonal therapies for the treatment of acne vulgaris...
May 27, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28560299/the-age-old-problem-of-acne
#14
N F Mahmood, A R Shipman
Acne vulgaris is one of the top three most commonly encountered dermatological problems worldwide in both primary and secondary care. Acne diagnosis and treatment date back to ancient Greek and Egyptian times. This article explores acne through the ages and discusses past theories on etiology and treatment with particular focus on the discovery of retinoids and their impact on women's health.
June 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28556980/acne-morphologic-and-vascular-study-of-lesions-and-surrounding-skin-by-means-of-optical-coherence-tomography
#15
M Manfredini, M Greco, F Farnetani, S Ciardo, N De Carvalho, V D Mandel, M Starace, G Pellacani
BACKGROUND: Acne vulgaris is a disease of the pilosebaceous unit, characterized by hyper-keratinization process, comedos formation and inflammatory reactions. OBJECTIVE: The definition of the morphology and the vascularization of acne lesions by means of dynamic optical coherence tomography (D-OCT), in order to non-invasively define the alterations occurring during the acne development and patient therapeutic management. METHODS: A set of standardized clinical pictures and D-OCT images were acquired from 114 acne lesions of 31 volunteers, presenting mild to moderate acne and evaluated by experts...
May 30, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28549948/microneedles-in-the-clinic
#16
REVIEW
Shubhmita Bhatnagar, Kaushalkumar Dave, Venkata Vamsi Krishna Venuganti
In general, there is a profound influence of reducing physical dimensions of particulates and devices on their physico-chemical and biological properties, and their performance. Reduction in the dimensions of hypodermic needle to micron-scale size has gained tremendous interest among researchers. Research efforts and publications investigating the design, development and applications of microneedles have exponentially increased in the recent years. Especially, microneedles have been widely studied and developed for cosmetic and therapeutic applications...
May 23, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28545314/letter-to-the-editor-submitted-in-response-to-the-extinction-of-topical-erythromycin-therapy-for-acne-vulgaris-and-concern-for-the-future-of-topical-clindamycin
#17
Tanvi Gupta, Kabir Sardana, Bipul Kumar, Hemant K Gautam
No abstract text is available yet for this article.
June 8, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28538881/efficacy-and-safety-of-superficial-chemical-peeling-in-treatment-of-active-acne-vulgaris
#18
Hassanain Al-Talib, Alyaa Al-Khateeb, Ayad Hameed, Chandrika Murugaiah
Acne vulgaris is an extremely common condition affecting the pilosebaceous unit of the skin and characterized by presence of comedones, papules, pustules, nodules, cysts, which might result in permanent scars. Acne vulgaris commonly involve adolescents and young age groups. Active acne vulgaris is usually associated with several complications like hyper or hypopigmentation, scar formation and skin disfigurement. Previous studies have targeted the efficiency and safety of local and systemic agents in the treatment of active acne vulgaris...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28533848/dermatology-in-ghana-a-retrospective-review-of-skin-disease-at-the-korle-bu-teaching-hospital-dermatology-clinic
#19
Brooke E Rosenbaum, Rebecca Klein, Paa Gyasi Hagan, Mark-Young Seadey, Naa Larteley Quarcoo, Rachel Hoffmann, Maria Robinson, Margaret Lartey, Marie C Leger
INTRODUCTION: Ghana is currently developing its provision of dermatology services. Epidemiologic studies of the skin diseases seen by Ghanaian dermatologists are needed to guide these efforts. We aimed to describe the skin conditions seen by and management practices of Ghanaian dermatologists in a specialized clinic. METHODS: We conducted a chart review of new patients presenting to the Korle Bu Teaching Hospital dermatology clinic during 2014. RESULTS: Among the 529 patients studied, 700 discrete diagnoses were made...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28528603/a-retrospective-study-of-multiple-sequential-light-and-laser-sources-to-activate-aminolevulinic-acid-in-the-treatment-of-acne-vulgaris
#20
Daniel P Friedmann, Mitchel P Goldman, Sabrina G Fabi, Isabella Guiha
Reports of the sequential use of multiple light and laser sources for topical 5-aminolevulinic acid (ALA) activation in photodynamic therapy (PDT) of inflammatory acne vulgaris are lacking. The authors sought to retrospectively compare field-directed ALA-PDT with blue light only, blue light + pulsed dye laser (PDL), blue light + intense pulsed light (IPL), blue light + PDL + IPL, or blue light + red light + PDL + IPL for inflammatory acne of the face or upper trunk. Results showed a trend toward greater patient-reported improvement with comparable tolerability using multiple, sequential light sources in ALA-PDT for acne vulgaris, albeit not statistically significant...
2017: Skinmed
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