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Acne vulgaris

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https://www.readbyqxmd.com/read/28913735/efficacy-and-safety-of-tazarotene-0-1-plus-clindamycin-1-gel-versus-adapalene-0-1-plus-clindamycin-1-gel-in-facial-acne-vulgaris-a-randomized-controlled-clinical-trial
#1
Rituparna Maiti, Chandra Sekhar Sirka, M A Ashique Rahman, Anand Srinivasan, Sansita Parida, Debasish Hota
BACKGROUND: Acne vulgaris is a multifactorial disorder which is ideally treated with combination therapy with topical retinoids and antibiotics. OBJECTIVES: The present study was conducted to compare the efficacy and safety of tazarotene plus clindamycin against adapalene plus clindamycin in facial acne vulgaris. METHODS: This study is a randomized, open-label, parallel design clinical trial conducted on 60 patients with facial acne at the outpatient dermatology department in a tertiary healthcare center...
September 14, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28912911/doxycycline-induced-acute-pancreatitis-a-rare-adverse-event
#2
Prashanth Rawla, Jeffrey Pradeep Raj
Doxycycline is a broad-spectrum antibiotic belonging to the tetracycline group which acts by inhibiting bacterial protein synthesis. It is considered to be a relatively safe drug. We report a case of doxycycline-induced acute pancreatitis (DIAP) in an adult female patient who was started on the usual therapeutic dose 1 week before for acne vulgaris. The WHO causality assessment was possible, and the Naranjo scale confirmed it as "definite" adverse drug reaction. A brief literature review on case reports previously reporting DIAP has also been summarized...
August 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/28902026/chemical-peels-indications-and-special-considerations-for-the-male-patient
#3
Jeave Reserva, Amanda Champlain, Seaver L Soon, Rebecca Tung
BACKGROUND: Chemical peels are a mainstay of aesthetic medicine and an increasingly popular cosmetic procedure performed in men. OBJECTIVE: To review the indications for chemical peels with an emphasis on performing this procedure in male patients. MATERIALS AND METHODS: Review of the English PubMed/MEDLINE literature and specialty texts in cosmetic dermatology, oculoplastic, and facial aesthetic surgery regarding sex-specific use of chemical peels in men...
September 4, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28895889/the-skin-bacterium-propionibacterium-acnes-employs-two-variants-of-hyaluronate-lyase-with-distinct-properties
#4
Seven Nazipi, Kristian Stødkilde-Jørgensen, Carsten Scavenius, Holger Brüggemann
Hyaluronic acid (HA) and other glycosaminoglycans are extracellular matrix components in the human epidermis and dermis. One of the most prevalent skin microorganisms, Propionibacterium acnes, possesses HA-degrading activity, possibly conferred by the enzyme hyaluronate lyase (HYL). In this study, we identified the HYL of P. acnes and investigated the genotypic and phenotypic characteristics. Investigations include the generation of a P. acneshyl knockout mutant and HYL activity assays to determine the substrate range and formed products...
September 12, 2017: Microorganisms
https://www.readbyqxmd.com/read/28891036/acne-scars-how-do-we-grade-them
#5
Ashley K Clark, Suzana Saric, Raja K Sivamani
Acne vulgaris is a chronic inflammatory skin disease that can lead to permanent scarring. Although grading scales exist for acne scarring, there are many limitations, and there is still a need for a well validated gold standard scale for use in clinical practice or research trials. An objective measure of scar severity should be a component of global acne severity evaluations. This manuscript reviews currently available acne scar grading modalities: lesion counting; subjective self-assessment; Acne Scar Rating Scale (ASRS); evaluator-based qualitative and quantitative scarring grading systems; Echelle d'Evaluation Clinique des Cicatrices d'acne (ECCA); Global Scale for Acne Scar Severity (SCAR-S); and imaging...
September 11, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28884496/potential-role-of-curcumin-against-biofilm-producing-organisms-on-the-skin-a-review
#6
REVIEW
Alexandra R Vaughn, Kelly N Haas, Waqas Burney, Erich Andersen, Ashley K Clark, Robert Crawford, Raja K Sivamani
Turmeric root (Curcuma longa) is predominantly used as a spice, but has also long been known to possess antimicrobial, analgesic, antiinflammatory, and anticancer properties. One predominant group of active compounds in turmeric are curcuminoids, namely bright yellow-pigmented curcumin. While modern science has yet to fully investigate the therapeutic claims of turmeric and its derivatives, results have proven promising in decreasing pain and inflammation in arthritis, improving insulin sensitivity in diabetes, and even curing a variety of infections...
September 7, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28875271/comparative-effects-of-schisandrin-a-b-and-c-on-acne-related-inflammation
#7
Miaomiao Guo, Faliang An, Xing Wei, Minhua Hong, Yanhua Lu
Inflammatory responses induced by Propionibacterium acnes are a major etiological factor in the pathogenesis of acne vulgaris. Schisandrin A, schisandrin B, and schisandrin C are the representative lignans of Schisandra chinensis (Turcz.) Baill. extract. Although anti-inflammatory effects of the lignans have been shown, their effects on acne-related inflammation caused by P. acnes have not been investigated and compared. We pretreated THP-1 human monocytic cells with 5, 10, and 20 μM schisandrin A, B, and C, and stimulated the cells with P...
September 5, 2017: Inflammation
https://www.readbyqxmd.com/read/28873106/comparison-of-salicylic-acid-30-peel-and-pneumatic-broadband-light-in-the-treatment-of-mild-to-moderately-severe-facial-acne-vulgaris
#8
Rattapon Thuangtong, Chinmanat Tangjaturonrusamee, Pinyo Rattanaumpawan, Chérie M Ditre
Acne patients experience not only a medical disease but also an aesthetic condition, and this latter complication greatly motivates patients to seek out the best treatment regimen to hasten improvement in their appearance. The available clinical procedures for acne treatment include salicylic acid 30% peel and pneumatic broadband light (PBBL). The objective of this study was to compare the efficacy of salicylic acid 30% peel and PBBL treatments in patients with mild to moderately severe facial acne vulgaris...
July 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28871926/translation-and-validation-of-the-serbian-version-of-the-skindex-29-instrument-for-measuring-impact-of-skin-disease-on-quality-of-life
#9
Jelena D Milutinović, Nebojša Krstić, Slobodan M Janković
The Skindex-29 instrument, which is intended for measuring the influence of skin diseases on quality of life, was developed and validated in several languages. However, a Serbian translation of the instrument is not available. The aim of this study was to translate the Skindex-29 from English to Serbian, to make necessary cultural adaptations, and to test its psychometric properties in a sample of outpatients with various skin diseases. The Skindex-29 was translated and adapted according to internationally accepted guidelines and then tested on a sample of Serbian outpatients with various skin diseases...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28867856/physicochemical-screening-and-shelf-life-evaluation-of-ku%C3%A1-kum%C3%A4-di-gh%C3%A1-ta-prepared-using-kesara-and-n%C3%A4-gakesara
#10
Pradeep Kumar Prajapati, Rohit Sharma, Amee Amrutia, B J Patgiri
INTRODUCTION: Kuṅkumādi Ghṛta (KG) is an Ayurvedic formulation commonly recommended in skin disorders, especially Mukhadūṣikā (Acne vulgaris). Kesara (stigma of Crocus sativus Linn.) is a prime ingredient in the formulation. However, due to high cost and increased adulteration in Kesara, 'Nāgakesara' (Mesua ferrea Linn.) is suggested by Ayurvedic experts as a substitute. Nāgakesara is relatively lower in cost and possesses similar therapeutic attributes to that of Kesara. Recent studies have established standard manufacturing procedures and clinical efficacies of Kesarayukta (with Kesara) Kuṅkumādi Ghṛta (KKG) and Nāgakesara yukta (with Nāgakesara) Kuṅkumādi Ghṛta (NKG) in Mukhadūṣikā...
January 2017: Ancient Science of Life
https://www.readbyqxmd.com/read/28857716/chronic-cutaneous-lupus-erythematosus-presenting-as-atypical-acneiform-and-comedonal-plaque-case-report-and-literature-review
#11
M L Vieira, E R M C Marques, Y L A Leda, L F Noriega, D L Bet, G A A M Pereira
Introduction Chronic cutaneous lupus erythematosus (CCLE) usually presents as characteristic erythematous patches and infiltrated coin-shaped plaques. However, there are some atypical clinical variants that may mimic other dermatological conditions. Haroon et al. reported in 1972 an unusual presentation of CCLE with hypertrophic follicular scars seen in acne vulgaris. Acneiform presentation is one of the most rarely reported and one of the most confusing, as it resembles a very common inflammatory skin disease...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28857398/predictive-value-of-serum-markers-for-postacne-scarring
#12
Abdel Aziz El-Taweel, Rehab Mohammed Salem, Ola S El-Shimi
BACKGROUND: Postacne scarring is the main concern of many acne patients. Predicting the liability to scarring can alter the management protocols and help in preventing such disfigurement. METHODS: Sixty patients with moderate to severe acne vulgaris (according to Global Acne Grading system) were included, only 35 of them had postacne scars. A quantitative latex agglutination commercial kit was used to assess serum C-reactive protein (CRP) concentration by turbidimetry, while serum hepcidin concentration was assessed by a commercially available double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) kit...
August 30, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28855974/the-skin-microbiome-impact-of-modern-environments-on-skin-ecology-barrier-integrity-and-systemic-immune-programming
#13
REVIEW
Susan L Prescott, Danica-Lea Larcombe, Alan C Logan, Christina West, Wesley Burks, Luis Caraballo, Michael Levin, Eddie Van Etten, Pierre Horwitz, Anita Kozyrskyj, Dianne E Campbell
Skin barrier structure and function is essential to human health. Hitherto unrecognized functions of epidermal keratinocytes show that the skin plays an important role in adapting whole-body physiology to changing environments, including the capacity to produce a wide variety of hormones, neurotransmitters and cytokine that can potentially influence whole-body states, and quite possibly, even emotions. Skin microbiota play an integral role in the maturation and homeostatic regulation of keratinocytes and host immune networks with systemic implications...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28853968/evaluation-of-autologous-platelet-rich-plasma-plus-ablative-carbon-dioxide-fractional-laser-in-the-treatment-of-acne-scars
#14
Ahmed Mohammed Abdel Aal, Ibrahim Maeraj Ibrahim, Nevein Ahmed Sami, Ibrahim Mohammed Abdel Kareem
INTRODUCTION: Acne scar is a common distressing complication of acne vulgaris. CO2 laser resurfacing proved effective for treatment of such problem but the associated complications may limit its use. Platelet rich plasma (PRP) may increase the chance of favorable outcome. AIM OF THE WORK: To evaluate the synergistic effects of autologous PRP with fractional CO2 laser resurfacing in treatment of acne scars among Egyptian patients. PATIENTS AND METHOD: This study included 30 patients suffering from post-acne scars...
August 30, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28831837/racial-disparities-in-the-management-of-acne-evidence-from-the-national-ambulatory-medical-care-survey-2005-2014
#15
Andrew T Rogers, Yevgeniy R Semenov, Shawn G Kwatra, Ginette A Okoye
PURPOSE: Racial health disparities are widespread in the United States, but little is known about racial disparities in the management of dermatological conditions. MATERIALS AND METHODS: Nationally representative data on the management of acne vulgaris were gathered from the National Ambulatory Medical Care Survey for the years 2005-2014. Visits to any specialist were included. Rao-Scott chi-square tests and multivariate adjusted logistic regressions were used to identify differences in patient demographics, visit characteristics, and acne medications across races...
August 23, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28831424/management-of-severe-acne-during-pregnancy-a-case-report-and-review-of-the-literature
#16
S Z Awan, J Lu
The treatment of acne during pregnancy is often limited by the potential toxicities that are posed to the fetus by the most common and effective acne therapies. As with all dermatoses during pregnancy, the treatment of acne vulgaris in this population requires a thorough understanding of the risks and benefits that are inherent to each treatment. We report on a case of a 30-year-old pregnant patient with severe acne conglobata who showed significant improvement with a combination treatment of topical modalities, oral metronidazole, and low dose prednisone during pregnancy...
September 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28831246/general-quality-of-life-of-patients-with-acne-vulgaris-before-and-after-performing-selected-cosmetological-treatments
#17
Karolina Chilicka, Joanna Maj, Bernard Panaszek
BACKGROUND: Achieving a satisfying quality of life for a patient by applying individually matched therapy is, simultaneously, a great challenge and a priority for contemporary medicine. Patients with visible dermatological ailments are particularly susceptible to reduction in the general quality of life. Among the dermatological diseases, acne causes considerable reduction in the quality of life and changes in self-perception that lead to the worsening of a patient's mental condition, including depression and suicidal thoughts...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28827969/evaluation-of-anti-inflammatory-and-antimicrobial-activity-of-ahpl-aycap-0413-capsule
#18
Sanjay Nipanikar, Sohan Chitlange, Dheeraj Nagore
BACKGROUND: Conventional therapeutic agents used for treatment of Acne are associated with various adverse effects necessitating development of safe and effective alternative therapeutic agents. In this context, a polyherbal formulation AHPL/AYCAP/0413 was developed for treatment of Acne. OBJECTIVES: To evaluate Anti-inflammatory and antimicrobial activity of AHPL/AYCAP/0413. MATERIAL AND METHODS: 1) Anti-inflammatory activity: Anti-inflammatory activity of AHPL/AYCAP/0413 in comparison with Diclofenac was assessed in carrageenan induced rat Paw edema model...
July 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28814964/milk-disrupts-p53-and-dnmt1-the-guardians-of-the-genome-implications-for-acne-vulgaris-and-prostate-cancer
#19
Bodo C Melnik
There is accumulating evidence that milk shapes the postnatal metabolic environment of the newborn infant. Based on translational research, this perspective article provides a novel mechanistic link between milk intake and milk miRNA-regulated gene expression of the transcription factor p53 and DNA methyltransferase 1 (DNMT1), two guardians of the human genome, that control transcriptional activity, cell survival, and apoptosis. Major miRNAs of milk, especially miRNA-125b, directly target TP53 and complex p53-dependent gene regulatory networks...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28799643/sebocytes-contribute-to-skin-inflammation-by-promoting-the-differentiation-of-th17-cells
#20
M Mattii, M Lovászi, N Garzorz, A Atenhan, M Quaranta, F Lauffer, A Konstantinow, M Küpper, C C Zouboulis, L Kemeny, K Eyerich, C B Schmidt-Weber, D Törőcsik, S Eyerich
BACKGROUND: The main function of sebocytes is considered to be the lipid production for moisturizing the skin. However, it became recently apparent that sebocytes release chemokines and cytokines and respond to pro-inflammatory stimuli as well as presence of bacteria. OBJECTIVES: To analyze the functional communication between human sebocytes and T cells. METHODS: Immunofluorescence stainings for CD4 and IL-17 were performed on acne sections and healthy skin...
August 11, 2017: British Journal of Dermatology
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