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Acne vulgaris

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https://www.readbyqxmd.com/read/29344322/acne-scarring-pathogenesis-evaluation-and-treatment-options
#1
REVIEW
Deirdre Connolly, Ha Linh Vu, Kavita Mariwalla, Nazanin Saedi
Acne vulgaris is a ubiquitous problem affecting 80 percent of people ages 11 to 30 years, with many patients experiencing some degree of scarring. This review focuses on atrophic scars, the most common type of acne scar. We briefly address the cellular sequelae that lead to scar formation and the initial evaluation of patients with acne scars. We then discuss an algorithmic approach to the treatment of acne scarring based on the classification of scars into erythematous and atrophic types. Lastly, we discuss the future treatment of acne scars and ongoing clinical trials...
September 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29304516/ablative-fractional-co2-laser-for-facial-atrophic-acne-scars
#2
Yaqin Xu, Yunhua Deng
Ablative fractional carbon dioxide laser resurfacing is a well-established treatment for acne scars. However, there are limited consensus and guidelines regarding the procedure, such as its treatment plan, efficacy, and safety. In this study, we performed a systematic review to assess the efficacy and safety of the fractional carbon dioxide laser treatment procedure, and to provide evidence-based recommendations concerning its practical use on atrophic acne scars. A comprehensive search was performed in, EMBASE, Ovid, Web of Science, and Cochrane databases, using the keywords "scar(s)," "acne vulgaris," "carbon dioxide," and "fraction* laser(s)" for the period from January 1987 to December 2016...
January 5, 2018: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/29285776/association-of-the-cyp17-msp-ai-t-34c-and-cyp19-codon-39-trp-arg-polymorphisms-with-susceptibility-to-acne-vulgaris
#3
F Chamaie-Nejad, S Saeidi, F Najafi, A Ebrahimi, Z Rahimi, E Shakiba, Z Rahimi
The aim of this study was to detect the association of the cytochrome P450 (CYP) 17 T-34C and CYP19 T<C polymorphisms with the risk of acne vulgaris (AV). The study enrolled 198 patients with AV (mild, moderate and severe) and 195 unrelated age-matched healthy controls from western Iran who had Kurdish ethnic background. The presence of the CYP17 TC genotype significantly increased the risk of mild, moderate and severe AV by 2.68, 2.28 and 2.94 times, respectively, while the presence of the CYP19 TC genotype significantly elevated the risk of overall AV and mild AV by 2...
December 28, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29280553/dapsone-for-topical-use-in-extemporaneous-preparations
#4
Johannes Wohlrab, Julia Michael
BACKGROUND: The sulfone dapsone has an established role in systemic therapy. Its pharmacological and toxicological properties are well known. Topically, dapsone is used in a gel formulation for the treatment of acne vulgaris. In addition, there have been individual case reports on the efficacy of topical dapsone preparations in the treatment of various neutrophilic dermatoses. To date, no finished medicinal product for topical use has been available in Germany. MATERIAL AND METHODS: Against this background, we set out to develop extemporaneous preparations containing dapsone (5 %) that meet the quality requirements of the European Pharmacopoeia as well as the manufacturing requirements of the German Ordinance on the Operation of Pharmacies (ApBetrO)...
December 27, 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29261843/using-network-oriented-research-assistant-nora-technology-to-compare-digital-photographic-with-in-person-assessment-of-acne-vulgaris
#5
Hannah M Singer, Timothy Almazan, Noah Craft, Consuelo V David, Samantha Eells, Crisel Erfe, Cynthia Lazzaro, Kathy Nguyen, Katy Preciado, Belinda Tan, Vishal A Patel
Importance: Teledermatology has undergone exponential growth in the past 2 decades. Many technological innovations are becoming available without necessarily undergoing validation studies for specific dermatologic applications. Objective: To determine whether patient-taken photographs of acne using Network Oriented Research Assistant (NORA) result in similar lesion counts and Investigator's Global Assessment (IGA) findings compared with in-person examination findings...
December 20, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29241756/gynecologic-and-andrologic-dermatology-and-the-metabolic-syndrome
#6
Maria Magdalena Roth, Nicholas Leader, George Kroumpouzos
The relationship of sex hormones to obesity and inflammation has been extensively studied. Research on endogenous and exogenous sex steroids, including studies on animal models of metabolic syndrome (MetS), has indicated that sex hormones are involved in metabolic pathways relevant to MetS. Lower testosterone levels in men and higher levels in women increase risks of MetS and type 2 diabetes mellitus (T2DM). Lower levels of sex hormone-binding globulin increase risks of MetS and T2DM in both sexes. Skin diseases that are sex hormone mediated, such as polycystic ovary syndrome, acanthosis nigricans, acne vulgaris, and pattern alopecia, have been associated with insulin resistance...
January 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29241749/acne-vulgaris-the-metabolic-syndrome-of-the-pilosebaceous-follicle
#7
Bodo C Melnik
Acne vulgaris is an epidemic inflammatory disease of the human sebaceous follicle and represents the most common skin disease affecting about 85% of adolescents in Westernized populations. Acne vulgaris is primarily a disease of wealthy countries and exhibits higher prevalence rates in developed compared with developing countries. No acne has been found in non-Westernized populations still living under Paleolithic dietary conditions constraining hyperglycemic carbohydrates, milk, and dairy products. The high prevalence rates of adolescent acne cannot be explained by the predominance of genetic factors but by the influence of a Western diet that overstimulates the key conductor of metabolism, the nutrient- and growth factor-sensitive kinase mTORC1...
January 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29235673/long-term-administration-of-oral-macrolides-for-acne-treatment-increases-macrolide-resistant-propionibacterium-acnes
#8
Keisuke Nakase, Yuhei Okamoto, Sae Aoki, Norihisa Noguchi
Macrolide-resistant Propionibacterium acnes are frequently isolated from patients with acne vulgaris, and the most resistant isolates (>90% resistance) have the 23S rRNA mutation. An increase in resistant P. acnes with this mutation is thought to be caused by the inappropriate use of antimicrobials. Therefore, we studied the mutation frequency of macrolide resistance in P. acnes in vitro. When P. acnes mutants were exposed to clarithromycin after being incubated in broth without antimicrobials, resistant mutants with the 23S rRNA mutation were not isolated...
December 13, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29230330/calcifying-acne-an-unusual-extraoral-radiographic-finding
#9
Thomas Horgan, Catherine McNamara, Anthony Ireland, Jonathan Sandy, James Puryer
Calcinosis cutis is a condition of accumulation of calcium salts within the dermis leading to the formation of a calcified mass. This complication has been reported in acne vulgaris and other systemic metabolic disorders. This paper presents a rare case of calcinosis cutis in a 14-year-old male which was found at a routine orthodontic assessment.
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/29207817/immunohistochemical-expression-of-cyclo-oxygenase-2-and-liver-x-receptor-%C3%AE-in-acne-vulgaris
#10
Ola Ahmed Bakry, Shawky Mahmoud El Farargy, Noha Nour El Din El Kady, Hend Farag Abu Dawy
Introduction: Acne Vulgaris (AV) is a common inflammatory disease of pilosebaceous units. Liver X Receptor-α (LXR-α) is a ligand activated transcription factor. It controls transcription of genes involved in lipid and fatty acid synthesis. Cyclo-oxygenase 2 (COX2) is a rate limiting enzyme in prostaglandin synthesis. It plays important role in inflammation. Aim: To evaluate the immunohistochemical expression of LXR-α and COX2 in acne vulgaris skin biopsies to explore their possible pathogenic role in this disease...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29205339/acne-in-late-adolescence-and-risk-of-prostate-cancer
#11
Henrik Ugge, Ruzan Udumyan, Jessica Carlsson, Ove Andrén, Scott Montgomery, Sabina Davidsson, Katja Fall
Accumulating evidence suggest that Propionibacterium acnes may play a role in prostate carcinogenesis, but data are so far limited and inconclusive. The aim of this population-based cohort study was therefore to test whether presence of acne vulgaris during late adolescence is associated with an increased risk of prostate cancer later in life. We identified a large cohort of young men born in Sweden between 1952 and 1956, who underwent mandatory assessment for military conscription around the age of 18 (n = 243,187)...
December 4, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29201018/prevalence-of-flp-pili-encoding-plasmids-in-cutibacterium-acnes-isolates-obtained-from-prostatic-tissue
#12
Sabina Davidsson, Jessica Carlsson, Paula Mölling, Natyra Gashi, Ove Andrén, Swen-Olof Andersson, Elzbieta Brzuszkiewicz, Anja Poehlein, Munir A Al-Zeer, Volker Brinkmann, Carsten Scavenius, Seven Nazipi, Bo Söderquist, Holger Brüggemann
Inflammation is one of the hallmarks of prostate cancer. The origin of inflammation is unknown, but microbial infections are suspected to play a role. In previous studies, the Gram-positive, low virulent bacterium Cutibacterium (formerly Propionibacterium) acnes was frequently isolated from prostatic tissue. It is unclear if the presence of the bacterium represents a true infection or a contamination. Here we investigated Cutibacterium acnes type II, also called subspecies defendens, which is the most prevalent type among prostatic C...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29200756/g2a-attenuates-propionibacterium-acnes-induction-of-inflammatory-cytokines-in-human-monocytes
#13
Andrew J Park, George W Agak, Min Qin, Lisa D Hisaw, Aslan Pirouz, Stephanie Kao, Laura J Marinelli, Hermes J Garbán, Diane Thiboutot, Philip T Liu, Jenny Kim
Background: Acne vulgaris is a disease of the pilosebaceous unit characterized by increased sebum production, hyperkeratinization, and immune responses to Propionibacterium acnes (PA). Here, we explore a possible mechanism by which a lipid receptor, G2A, regulates immune responses to a commensal bacterium. Objective: To elucidate the inflammatory properties of G2A in monocytes in response to PA stimulation. Furthermore, our study sought to investigate pathways by which lipids modulate immune responses in response to PA...
December 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/29197171/evaluation-of-the-effects-of-acne-vulgaris-on-quality-of-life-in-turkey-by-using-taqli
#14
Hilal Gokalp, Isil Bulur, Hilal Kaya Erdoğan, Tekden Karapınar, Muzaffer Bilgin
BACKGROUND: Acne vulgaris (AV) is a chronic, inflammatory skin disease that may cause various psychiatric and/or psychological problems. OBJECTIVE: In this study, we aimed to determine the effect of AV on the quality of life in the Turkish population using the Turkish Acne Quality of Life Index (TAQLI). METHODS: A total of 960 patients with AV who attended the dermatology department were included in the study. Acne severity was determined using the global acne classification system...
December 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29193602/the-role-of-zinc-in-the-treatment-of-acne-a-review-of-the-literature
#15
REVIEW
Jessica Cervantes, Ariel E Eber, Marina Perper, Vanessa M Nascimento, Keyvan Nouri, Jonette E Keri
Acne vulgaris is a chronic disease of the pilosebaceous units presenting as inflammatory or noninflammatory lesions in individuals of all ages. The current standard of treatment includes topical formulations in the forms of washes, gels, lotions, and creams such as antibiotics, antibacterial agents, retinoids, and comedolytics. Additionally, systemic treatments are available for more severe or resistant forms of acne. Nevertheless, these treatments have shown to induce a wide array of adverse effects, including dryness, peeling, erythema, and even fetal defects and embolic events...
November 28, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/29186247/a-new-optical-intra-tissue-fiber-irradiation-ala-pdt-in-the-treatment-of-acne-vulgaris-in-rabbit-model-improved-safety-and-tolerability
#16
Qian Wang, Can Jiang, Wei Liu, Jin Chen, Xinyu Lin, Xiangning Huang, Xiling Duan
BACKGROUND: Photodynamic therapy with topical aminolevulinic acid (ALA-PDT) has been suggested to be effective in treatment of acne vulgaris. However, adverse events occur during and after treatment. OBJECTIVES: To compare the efficacy and tolerability of optical intra-tissue fiber irradiation (OFI) ALA-PDT versus traditional ALA-PDT in treatment of acne vulgaris in rabbit models. METHODS: Twenty-five rabbits of clean grade were used. Twenty rabbits were randomly selected to establish acne model and the other five were used as control...
May 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29184811/dermatologic-manifestations-of-endocrine-disorders
#17
REVIEW
Michael Lause, Alisha Kamboj, Esteban Fernandez Faith
The skin serves as a window for clinicians to understand, diagnose, and monitor endocrine disease. Dermatologic manifestations of endocrinopathies contribute significantly to an individual's health and quality of life. In this review, we outline various disorders of the hypothalamic-pituitary axis, thyroid gland, pancreas, adrenal gland, and androgen axis as well as hereditary endocrine syndromes. In acromegaly, glycosaminoglycan deposition contributes to a thickening of skin and soft tissue, which manifests as coarsening and enlargement of facial and acral structures...
October 2017: Translational pediatrics
https://www.readbyqxmd.com/read/29180907/clinical-behavior-of-a-cohort-of-adult-women-with-facial-acne-treated-with-combined-oral-contraceptive-ethinylestradiol-20-%C3%A2%C2%B5g-dienogest-2-mg
#18
John Palacio-Cardona, Diana María Caicedo Borrero
Acne vulgaris is the most common skin disease. It affects the young adult female population and generates great impact on physical and mental health. One of the treatments with good results for affected women is combined oral contraceptive pills (COCPs). The aim of this study was to determine the clinical effect of facial acne management with ethinylestradiol 20 µg/dienogest 2 mg in a cohort of Colombian adult women. A cohort of 120 female university students was followed for 12 months. These participants were enrolled in the Sexual and Reproductive Health Program of the Santiago de Cali University...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/29178495/novel-device-based-acne-treatments-comparison-of-a-1450-nm-diode-laser-and-microneedling-radiofrequency-on-mild-to-moderate-acne-vulgaris-and-seborrhoea-in-korean-patients-through-a-20-week-prospective-randomized-split-face-study
#19
H H Kwon, H Y Park, S C Choi, Y Bae, J Y Jung, G-H Park
BACKGROUND: While device-based acne treatments are widely applied for patients not tolerating conventional medications, related controlled studies have been still limited. Recently, non-ablative 1450-nm diode laser (DL) and fractional microneedling radiofrequency (FMR) have been effectively used for acne, in addition to well-recognized dermal remodelling effects. OBJECTIVE: To compare the clinical course of acne treatment between DL and FMR. METHODS: Twenty-five Korean patients with mild-to-moderate facial acne completed treatments with DL and FMR through a 20-week, randomized split-face study...
November 24, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29164826/comparative-study-of-buffered-50-glycolic-acid-ph-3-0-0-5-salicylic-acid-solution-vs-jessner-s-solution-in-patients-with-acne-vulgaris
#20
Jeong In Jae, Hyun Dong Ju, Kim Dong Hyun, Moon Soo Yoon, Hee Jung Lee
BACKGROUND: Superficial chemical peels are frequently used in acne vulgaris treatment. Although glycolic acid (GA) has been widely used in clinical practice, its pH ranges from 0.08-2.75 and thus should be neutralized after application to avoid burns. OBJECTIVE: To evaluate treatment efficacy and safety of chemical peeling using buffered 50% GA (pH 3.0) + 0.5% salicylic acid (SA) solution that does not need to be neutralized in the treatment of acne vulgaris compared to the conventional peeling using Jessner's solution...
November 21, 2017: Journal of Cosmetic Dermatology
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