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Electromagnetic therapy

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https://www.readbyqxmd.com/read/28092361/designed-cell-consortia-as-fragrance-programmable-analog-to-digital-converters
#1
Marius Müller, Simon Ausländer, Andrea Spinnler, David Ausländer, Julian Sikorski, Marc Folcher, Martin Fussenegger
Synthetic biology advances the rational engineering of mammalian cells to achieve cell-based therapy goals. Synthetic gene networks have nearly reached the complexity of digital electronic circuits and enable single cells to perform programmable arithmetic calculations or to provide dynamic remote control of transgenes through electromagnetic waves. We designed a synthetic multilayered gaseous-fragrance-programmable analog-to-digital converter (ADC) allowing for remote control of digital gene expression with 2-bit AND-, OR- and NOR-gate logic in synchronized cell consortia...
January 16, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28078187/bioelectric-field-enhancement-the-influence-on-membrane-potential-and-cell-migration-in-vitro
#2
Marcy C Purnell, Terence J Skrinjar
Objective: The extracellular matrix consists of critical components that affect fibroblast polarization and migration. The existence of both intrinsic and extrinsic electrical signals that play essential roles in the development, physiology, regeneration, and pathology of cells was discovered over a century ago. In this study, we study how the Bioelectric Field Enhancement (BEFE) device and its generated electromagnetic field (EMF) by continuous direct current (DC) significantly affect the membrane potential and cell migration of fibroblasts in vitro...
December 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/28072701/pathophysiology-of-refractory-obsessive-compulsive-disorder-a-study-of-visual-search-combined-with-overactive-performance-monitoring
#3
Qingxiao Liu, Bo Tan, Jing Zhou, Zhong Zheng, Ling Li, Yanchun Yang
Based on both functional and structural studies of excessive activity, fronto-striatal-thalamic-cortical and cortico-striatal circuits have been hypothesized to underlie the pathophysiology of obsessive-compulsive disorder (OCD). However, the neurobiological underpinnings of OCD refractory to medication and therapy remain controversial. This study aimed to evaluate neuroanatomical abnormalities of the whole brain and to evaluate visual processing in patients with refractory OCD.This study was comprised of 2 experiments...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28064222/pulsed-electromagnetic-field-stimulation-promotes-anti-cell-proliferative-activity-in-doxorubicin-treated-mouse-osteosarcoma-cells
#4
Yoshitaka Muramatsu, Takuya Matsui, Masataka Deie, Keiji Sato
AIM: We aimed to investigate the synergistic effects of pulsed electromagnetic field (PEMF) and doxorubicin therapy in a mouse osteosarcoma cell line (LM8 cells) in vitro. MATERIALS AND METHODS: The effects of PEMF (5 mT, 200 Hz) of different durations and doxorubicin on the proliferative activity of LM8 cells were measured by the MTT assay. Apoptotic-related factors such as cell-cycle phase, mitochondrial membrane potential, and caspase 3/7 activity were investigated using 4',6-diamidino-2-phenylindole staining and apoptosis kits...
2, 2017: In Vivo
https://www.readbyqxmd.com/read/28061923/electromagnetic-interference-in-implantable-defibrillators-in-single-engine-fixed-wing-aircraft
#5
Alexandra A J de Rotte, Peter van der Kemp, Peter A Mundy, Rienk Rienks, August A de Rotte
BACKGROUND: Little is known about the possible electromagnetic interferences (EMI) in the single-engine fixed-wing aircraft environment with implantable cardio-defibrillators (ICDs). Our hypothesis is that EMI in the cockpit of a single-engine fixed-wing aircraft does not result in erroneous detection of arrhythmias and the subsequent delivery of an inappropriate device therapy. METHODS: ICD devices of four different manufacturers, incorporated in a thorax phantom, were transported in a Piper Dakota Aircraft with ICAO type designator P28B during several flights...
January 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28048770/su-g-jep1-05-clinical-impact-of-mlc-tracking-for-lung-sabr
#6
V Caillet, E Colvill, K Szymura, M Stevens, J Booth, P Keall
PURPOSE: The objective of this study was to investigate the dosimetric benefits of multi-leaf collimator (MLC) tracking for lung SABR treatments in end-to-end clinically realistic planning and delivery scenarios. METHODS: The clinical benefits of MLC tracking were assessed using previously delivered treatment plans and physical experiments. The 10 most recent single lesion lung SABR patients were re-planned following a 4D-GTV-based real-time adaptive protocol (PTV defined as the end-of-exhalation GTV plus 5...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048649/tu-h-bra-07-design-construction-and-installation-of-an-experimental-beam-line-for-the-development-of-mri-linac-compatible-electron-accelerator
#7
B Whelan, P Keall, L Holloway, S Gierman, J Schmerge, S Tantawi, A Tremaine, A Trautwein, B Scott, R Fahrig
PURPOSE: MRI guided radiation therapy (MRIgRT) is a rapidly growing field; however, Linac operation in MRI fringe fields represents an ongoing challenge. We have previously shown in-silico that Linacs could be redesigned to function in the in-line orientation with no magnetic shielding by adopting an RF-gun configuration. Other authors have also published insilico studies of Linac operation in magnetic fields; however to date no experimental validation data is published. This work details the design, construction, and installation of an experimental beam line to validate our in-silico results...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048603/tu-h-bra-03-performance-of-a-clinical-gridded-electron-gun-in-magnetic-fields-implications-for-mri-linac-therapy
#8
B Whelan, M Bazalova-Carter, B Oborn, D Constantin, L Holloway, R Fahrig, P Keall
PURPOSE: Recent advances towards MRI Linac radiotherapy have motivated a wide range of studies characterizing electromagnetic interactions between the two devices. One of the most sensitive components is the linac electron gun. To data, only non gridded (diode) guns have been investigated however, most linac vendors utilize gridded (triode) guns, which enable efficient and robust beam gating. The purpose of this study was to develop a realistic model of a gridded gun used clinically, and to characterize its performance in magnetic fields...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048109/su-g-jep1-06-correlation-of-lung-tumor-motion-with-tumor-location-using-electromagnetic-tracking
#9
D Muccigrosso, N Maughan, H Schultejans, R Bera, P Parikh
PURPOSE: It is well known that lung tumors move with respiration. However, most measurements of lung tumor motion have studied long treatment times with intermittent imaging; those populations may not necessarily represent conventional LINAC patients. We summarized the correlation between tumor motion and location in a multi-institutional trial with electromagnetic tracking, and identified the patient cohort that would most benefit from respiratory gating. METHODS: Continuous electromagnetic transponder data (Varian Medical, Seattle, WA) of lung tumor motion was collected from 14 patients (214 total fractions) across 3 institutions during external beam radiation therapy in a prospective clinical trial (NCT01396551)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047824/th-b-204-02-application-of-implanted-markers-in-proton-therapy
#10
S Park
: Implanted markers as target surrogates have been widely used for treatment verification, as they provide safe and reliable monitoring of the inter- and intra-fractional target motion. The rapid advancement of technology requires a critical review and recommendation for the usage of implanted surrogates in current field. The symposium, also reporting an update of AAPM TG 199 - Implanted Target Surrogates for Radiation Treatment Verification, will be focusing on all clinical aspects of using the implanted target surrogates for treatment verification and related issues...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047474/su-f-j-10-sliding-mode-control-of-a-sma-actuated-active-flexible-needle-for-medical-procedures
#11
T Podder
PURPOSE: In medical interventional procedures such as brachytherapy, ablative therapies and biopsy precise steering and accurate placement of needles are very important for anatomical obstacle avoidance and accurate targeting. This study presents the efficacy of a sliding mode controller for Shape Memory Alloy (SMA) actuated flexible needle for medical procedures. METHODS: Second order system dynamics of the SMA actuated active flexible needle was used for deriving the sliding mode control equations...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047228/th-ab-202-05-best-in-physics-joint-imaging-therapy-first-online-ultrasound-guided-mlc-tracking-for-real-time-motion-compensation-in-radiotherapy
#12
S Ipsen, R Bruder, R O'Brien, P Keall, A Schweikard, P Poulsen
PURPOSE: While MLC tracking has been successfully used for motion compensation of moving targets, current real-time target localization methods rely on correlation models with x-ray imaging or implanted electromagnetic transponders rather than direct target visualization. In contrast, ultrasound imaging yields volumetric data in real-time (4D) without ionizing radiation. We report the first results of online 4D ultrasound-guided MLC tracking in a phantom. METHODS: A real-time tracking framework was installed on a 4D ultrasound station (Vivid7 dimension, GE) and used to detect a 2mm spherical lead marker inside a water tank...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046876/su-g-jep1-01-a-combination-of-real-time-electromagnetic-localization-and-tracking-with-cone-beam-computed-tomography-in-stereotactic-radiosurgery-for-brain-tumors
#13
K Raja Muralidhar, Suresh Pangam, Srinivas Ponaganti, Jayarama Krishna, Kolla V Sujana, Priya K Komanduri
PURPOSE: 1. online verification of patient position during treatment using calypso electromagnetic localization and tracking system. 2. Verification and comparison of positional accuracy between cone beam computed tomography and calypso system. 3. Presenting the advantage of continuation localization in Stereotactic radiosurgery treatments. METHODS: Ten brain tumor cases were taken for this study. Patients with head mask were under gone Computed Tomography (CT)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046411/th-b-204-00-implanted-markers-for-radiation-therapy-and-tg-199-update
#14
Zhiheng Wang
: Implanted markers as target surrogates have been widely used for treatment verification, as they provide safe and reliable monitoring of the inter- and intra-fractional target motion. The rapid advancement of technology requires a critical review and recommendation for the usage of implanted surrogates in current field. The symposium, also reporting an update of AAPM TG 199 - Implanted Target Surrogates for Radiation Treatment Verification, will be focusing on all clinical aspects of using the implanted target surrogates for treatment verification and related issues...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046302/th-cd-bra-01-best-in-physics-therapy-field-induced-dose-effects-in-a-mouse-lung-phantom-monte-carlo-and-experimental-assessments
#15
A Rubinstein, R Tailor, A Melancon, J Pollard, M Guindani, D Followill, J Hazle, L Court
PURPOSE: To simulate and measure magnetic-field-induced radiation dose effects in a mouse lung phantom. This data will be used to support pre-clinical experiments related to MRI-guided radiation therapy systems. METHODS: A mouse lung phantom was constructed out of 1.5×1.5×2.0-cm(3) lung-equivalent material (0.3 g/cm(3) ) surrounded by a 0.6-cm solid water shell. EBT3 film was inserted into the phantom and the phantom was placed between the poles of an H-frame electromagnet...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28031951/electromagnetic-fields-in-the-treatment-of-chronic-lower-back-pain-in-patients-with-degenerative-disc-disease
#16
Amarjit S Arneja, Alan Kotowich, Doug Staley, Randy Summers, Paramjit S Tappia
AIM: To examine the effects of low-amplitude, low frequency electromagnetic field therapy (EMF) therapy in patients with persistent chronic lower back pain associated with degenerative disc disease. DESIGN: Double-blind, randomized and placebo controlled. INTERVENTION: EMF using a medical device resonator; control group underwent same procedures, except the device was turned off. OUTCOME MEASURES: Pain reduction and mobility...
March 2016: Future Science OA
https://www.readbyqxmd.com/read/28028671/anesthesia-considerations-for-patients-with-an-implanted-deep-brain-stimulator-undergoing-surgery-a-review-and-update
#17
Tze Yeng Yeoh, Pirjo Manninen, Suneil K Kalia, Lashmi Venkatraghavan
PURPOSE: Deep brain stimulation (DBS) can be an effective treatment option for patients with essential tremor and Parkinson's disease. This review provides an overview on the functioning of neurostimulators and recent advances in this technology and presents an updated guide on the anesthetic management of patients with an implanted neurostimulator undergoing surgery or medical intervention. SOURCE: A search was conducted on MEDLINE®, EMBASE™, and Cochrane Database of Systematic Reviews databases to identify studies published in English from 1974 to December 2015...
December 27, 2016: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28002911/extracorporeal-shock-waves-induce-osteogenic-differentiation-of-human-bone-marrow-stromal-cells
#18
A Notarnicola, G Vicenti, G Maccagnano, F Silvestis, P Cafforio, B Moretti
The effects of treatment with shock waves (SW) on osteoblastic cells have already been described. Furthermore, the effects of treatment with SW are also determined by the contextual stimulation of other cell lines, in particular of mesenchymal cells. This is the first experimental study of stimulation of a human mesenchymal stem cell line, taken from bone marrow, using SW (electromagnetic device), with two energy levels. The results showed a significant increase in expression of the main osteoblastic differentiation genes: BMP2, alkaline phosphatase, osteocalcin, COL1A1, RUNX2...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27986082/mesenchymal-stem-cells-as-therapeutic-target-of-biophysical-stimulation-for-the-treatment-of-musculoskeletal-disorders
#19
REVIEW
Marco Viganò, Valerio Sansone, Maria Cristina d'Agostino, Pietro Romeo, Carlotta Perucca Orfei, Laura de Girolamo
BACKGROUND: Musculoskeletal disorders are regarded as a major cause of worldwide morbidity and disability, and they result in huge costs for national health care systems. Traditional therapies frequently turned out to be poorly effective in treating bone, cartilage, and tendon disorders or joint degeneration. As a consequence, the development of novel biological therapies that can treat more effectively these conditions should be the highest priority in regenerative medicine. Mesenchymal stem cells (MSCs) represent one of the most promising tools in musculoskeletal tissue regenerative medicine, thanks to their proliferation and differentiation potential and their immunomodulatory and trophic ability...
December 16, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27965542/releasing-the-cortical-brake-by-non-invasive-electromagnetic-stimulation-rtms-induces-ltd-of-gabaergic-neurotransmission
#20
REVIEW
Maximilian Lenz, Andreas Vlachos
Repetitive Transcranial Magnetic Stimulation (rTMS) is a non-invasive brain stimulation technique which modulates cortical excitability beyond the stimulation period. However, despite its clinical use rTMS-based therapies which prevent or reduce disabilities in a functionally significant and sustained manner are scarce. It remains unclear how rTMS-mediated changes in cortical excitability, which are not task- or input-specific, exert beneficial effects in some healthy subjects and patients. While experimental evidence exists that repetitive magnetic stimulation (rMS) is linked to the induction of long-term potentiation (LTP) of excitatory neurotransmission, less attention has been dedicated to rTMS-induced structural, functional and molecular adaptations at inhibitory synapses...
2016: Frontiers in Neural Circuits
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