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Electromagnetic therapy

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https://www.readbyqxmd.com/read/28164384/design-of-organic-macrocycle-modified-iron-oxide-nanoparticles-for-drug-delivery
#1
Ali Trabolsi, Tina Skorjanc, Farah Benyettou, John-Carl Olsen
Paul Ehrlich's vision of a "magic bullet" cure for disease inspires the modern design of nanocarriers whose purpose is to deliver drug cargo to specific sites in the body while circumventing endogenous immunological clearance mechanisms. Iron-oxide nanoparticles (IONPs) have emerged as particularly promising nanocarriers because of their biodegradability, ability to be guided magnetically to sites of pathology, mediation of hyperthermic therapy and imaging capabilities. In this review, we focus on the design and drug-delivery aspects of IONPs coated with organic macrocycles (crown ethers, cyclodextrins, calix[n]arenes, cucurbit[n]urils, or pillar[n]arenes) which, by means of reversible complexation, allow for the convenient loading and release of drug molecules...
February 5, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28149581/recent-advances-in-diagnostic-bronchoscopy
#2
REVIEW
Philip G Ong, Labib G Debiane, Roberto F Casal
The field of diagnostic bronchoscopy has been revolutionized in the last decade primarily with the advent of endobronchial ultrasound (EBUS) but also with the addition of multiple different techniques for "guided-bronchoscopy". These advances have had a substantial impact in the management of lung cancer with bronchoscopy now providing both diagnosis and mediastinal staging in a single procedure. EBUS has, in fact, become the first choice for staging of the mediastinum over cervical mediastinoscopy (CM). Although EBUS is now a well-established technique, there are continuous efforts from the scientific community to improve its diagnostic performance, and these will be reviewed in this manuscript...
December 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28128685/scar-remodeling-with-the-association-of-monopolar-capacitive-radiofrequency-electric-stimulation-and-negative-pressure
#3
Giovanni Nicoletti, Paola Perugini, Sara Bellino, Priscilla Capra, Alberto Malovini, Omar Jaber, Marco Tresoldi, Angela Faga
OBJECTIVE: A study was established to objectively assess the effects of low-intensity electromagnetic and electric stimulation plus negative pressure on mature scars. BACKGROUND: Radiofrequency plus negative pressure therapy demonstrated a favorable reorganization and regeneration of the collagen and elastic fibers and was proposed for the treatment of cellulitis and skin stretch marks. METHODS: Twenty-six mature scars in 20 Caucasian patients (15 females and 5 males) were enrolled in the study...
January 24, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28110721/transient-electro-magneto-hydrodynamic-two-phase-blood-flow-and-thermal-transport-through-a-capillary-vessel
#4
I A Mirza, M Abdulhameed, D Vieru, S Shafie
Therapies with magnetic/electromagnetic field are employed to relieve pains or, to accelerate flow of blood-particles, particularly during the surgery. In this paper, a theoretical study of the blood flow along with particles suspension through capillary was made by the electro-magneto-hydrodynamic approach. Analytical solutions to the non-dimensional blood velocity and non-dimensional particles velocity are obtained by means of the Laplace transform with respect to the time variable and the finite Hankel transform with respect to the radial coordinate...
December 2016: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28095547/prospective-internally-controlled-blind-reviewed-clinical-evaluation-of-cryolipolysis-combined-with-multipolar-radiofrequency-andvaripulsetechnology-for-enhanced-subject-results-in-circumferential-fat-reduction-and-skin-laxity-of-the-flanks
#5
Julius Few, Michael Gold, Neil Sadick
BACKGROUND: Increasing demand for non-invasive skin tightening and body contouring procedures has led to several technological in- novations in energy-based devices such as ultrasound, radiofrequency and cryolipolysis. An emerging trend in the eld is to evaluate whether combination therapies for skin laxity/body contouring using energy-based devices can deliver superior clinical results and patient satisfaction. As such, the objective of this prospective, internal-controlled, blind clinical study was to assess the safety and efficacy of cryolipolysis followed by multipolar radiofrequency with pulsed electromagnetic elds (PEMF) and adjustable pulsed suction for the treatment of skin laxity in the flanks...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28092361/designed-cell-consortia-as-fragrance-programmable-analog-to-digital-converters
#6
Marius Müller, Simon Ausländer, Andrea Spinnler, David Ausländer, Julian Sikorski, Marc Folcher, Martin Fussenegger
Synthetic biology advances the rational engineering of mammalian cells to achieve cell-based therapy goals. Synthetic gene networks have nearly reached the complexity of digital electronic circuits and enable single cells to perform programmable arithmetic calculations or to provide dynamic remote control of transgenes through electromagnetic waves. We designed a synthetic multilayered gaseous-fragrance-programmable analog-to-digital converter (ADC) allowing for remote control of digital gene expression with 2-bit AND-, OR- and NOR-gate logic in synchronized cell consortia...
March 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28078187/bioelectric-field-enhancement-the-influence-on-membrane-potential-and-cell-migration-in-vitro
#7
Marcy C Purnell, Terence J Skrinjar
Objective: The extracellular matrix consists of critical components that affect fibroblast polarization and migration. The existence of both intrinsic and extrinsic electrical signals that play essential roles in the development, physiology, regeneration, and pathology of cells was discovered over a century ago. In this study, we study how the Bioelectric Field Enhancement (BEFE) device and its generated electromagnetic field (EMF) by continuous direct current (DC) significantly affect the membrane potential and cell migration of fibroblasts in vitro...
December 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/28072701/pathophysiology-of-refractory-obsessive-compulsive-disorder-a-study-of-visual-search-combined-with-overactive-performance-monitoring
#8
Qingxiao Liu, Bo Tan, Jing Zhou, Zhong Zheng, Ling Li, Yanchun Yang
Based on both functional and structural studies of excessive activity, fronto-striatal-thalamic-cortical and cortico-striatal circuits have been hypothesized to underlie the pathophysiology of obsessive-compulsive disorder (OCD). However, the neurobiological underpinnings of OCD refractory to medication and therapy remain controversial. This study aimed to evaluate neuroanatomical abnormalities of the whole brain and to evaluate visual processing in patients with refractory OCD.This study was comprised of 2 experiments...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28064222/pulsed-electromagnetic-field-stimulation-promotes-anti-cell-proliferative-activity-in-doxorubicin-treated-mouse-osteosarcoma-cells
#9
Yoshitaka Muramatsu, Takuya Matsui, Masataka Deie, Keiji Sato
AIM: We aimed to investigate the synergistic effects of pulsed electromagnetic field (PEMF) and doxorubicin therapy in a mouse osteosarcoma cell line (LM8 cells) in vitro. MATERIALS AND METHODS: The effects of PEMF (5 mT, 200 Hz) of different durations and doxorubicin on the proliferative activity of LM8 cells were measured by the MTT assay. Apoptotic-related factors such as cell-cycle phase, mitochondrial membrane potential, and caspase 3/7 activity were investigated using 4',6-diamidino-2-phenylindole staining and apoptosis kits...
2, 2017: In Vivo
https://www.readbyqxmd.com/read/28061923/electromagnetic-interference-in-implantable-defibrillators-in-single-engine-fixed-wing-aircraft
#10
Alexandra A J de Rotte, Peter van der Kemp, Peter A Mundy, Rienk Rienks, August A de Rotte
BACKGROUND: Little is known about the possible electromagnetic interferences (EMI) in the single-engine fixed-wing aircraft environment with implantable cardio-defibrillators (ICDs). Our hypothesis is that EMI in the cockpit of a single-engine fixed-wing aircraft does not result in erroneous detection of arrhythmias and the subsequent delivery of an inappropriate device therapy. METHODS: ICD devices of four different manufacturers, incorporated in a thorax phantom, were transported in a Piper Dakota Aircraft with ICAO type designator P28B during several flights...
January 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28048770/su-g-jep1-05-clinical-impact-of-mlc-tracking-for-lung-sabr
#11
V Caillet, E Colvill, K Szymura, M Stevens, J Booth, P Keall
PURPOSE: The objective of this study was to investigate the dosimetric benefits of multi-leaf collimator (MLC) tracking for lung SABR treatments in end-to-end clinically realistic planning and delivery scenarios. METHODS: The clinical benefits of MLC tracking were assessed using previously delivered treatment plans and physical experiments. The 10 most recent single lesion lung SABR patients were re-planned following a 4D-GTV-based real-time adaptive protocol (PTV defined as the end-of-exhalation GTV plus 5...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048649/tu-h-bra-07-design-construction-and-installation-of-an-experimental-beam-line-for-the-development-of-mri-linac-compatible-electron-accelerator
#12
B Whelan, P Keall, L Holloway, S Gierman, J Schmerge, S Tantawi, A Tremaine, A Trautwein, B Scott, R Fahrig
PURPOSE: MRI guided radiation therapy (MRIgRT) is a rapidly growing field; however, Linac operation in MRI fringe fields represents an ongoing challenge. We have previously shown in-silico that Linacs could be redesigned to function in the in-line orientation with no magnetic shielding by adopting an RF-gun configuration. Other authors have also published insilico studies of Linac operation in magnetic fields; however to date no experimental validation data is published. This work details the design, construction, and installation of an experimental beam line to validate our in-silico results...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048603/tu-h-bra-03-performance-of-a-clinical-gridded-electron-gun-in-magnetic-fields-implications-for-mri-linac-therapy
#13
B Whelan, M Bazalova-Carter, B Oborn, D Constantin, L Holloway, R Fahrig, P Keall
PURPOSE: Recent advances towards MRI Linac radiotherapy have motivated a wide range of studies characterizing electromagnetic interactions between the two devices. One of the most sensitive components is the linac electron gun. To data, only non gridded (diode) guns have been investigated however, most linac vendors utilize gridded (triode) guns, which enable efficient and robust beam gating. The purpose of this study was to develop a realistic model of a gridded gun used clinically, and to characterize its performance in magnetic fields...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048109/su-g-jep1-06-correlation-of-lung-tumor-motion-with-tumor-location-using-electromagnetic-tracking
#14
D Muccigrosso, N Maughan, H Schultejans, R Bera, P Parikh
PURPOSE: It is well known that lung tumors move with respiration. However, most measurements of lung tumor motion have studied long treatment times with intermittent imaging; those populations may not necessarily represent conventional LINAC patients. We summarized the correlation between tumor motion and location in a multi-institutional trial with electromagnetic tracking, and identified the patient cohort that would most benefit from respiratory gating. METHODS: Continuous electromagnetic transponder data (Varian Medical, Seattle, WA) of lung tumor motion was collected from 14 patients (214 total fractions) across 3 institutions during external beam radiation therapy in a prospective clinical trial (NCT01396551)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047824/th-b-204-02-application-of-implanted-markers-in-proton-therapy
#15
S Park
: Implanted markers as target surrogates have been widely used for treatment verification, as they provide safe and reliable monitoring of the inter- and intra-fractional target motion. The rapid advancement of technology requires a critical review and recommendation for the usage of implanted surrogates in current field. The symposium, also reporting an update of AAPM TG 199 - Implanted Target Surrogates for Radiation Treatment Verification, will be focusing on all clinical aspects of using the implanted target surrogates for treatment verification and related issues...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047474/su-f-j-10-sliding-mode-control-of-a-sma-actuated-active-flexible-needle-for-medical-procedures
#16
T Podder
PURPOSE: In medical interventional procedures such as brachytherapy, ablative therapies and biopsy precise steering and accurate placement of needles are very important for anatomical obstacle avoidance and accurate targeting. This study presents the efficacy of a sliding mode controller for Shape Memory Alloy (SMA) actuated flexible needle for medical procedures. METHODS: Second order system dynamics of the SMA actuated active flexible needle was used for deriving the sliding mode control equations...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047228/th-ab-202-05-best-in-physics-joint-imaging-therapy-first-online-ultrasound-guided-mlc-tracking-for-real-time-motion-compensation-in-radiotherapy
#17
S Ipsen, R Bruder, R O'Brien, P Keall, A Schweikard, P Poulsen
PURPOSE: While MLC tracking has been successfully used for motion compensation of moving targets, current real-time target localization methods rely on correlation models with x-ray imaging or implanted electromagnetic transponders rather than direct target visualization. In contrast, ultrasound imaging yields volumetric data in real-time (4D) without ionizing radiation. We report the first results of online 4D ultrasound-guided MLC tracking in a phantom. METHODS: A real-time tracking framework was installed on a 4D ultrasound station (Vivid7 dimension, GE) and used to detect a 2mm spherical lead marker inside a water tank...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046876/su-g-jep1-01-a-combination-of-real-time-electromagnetic-localization-and-tracking-with-cone-beam-computed-tomography-in-stereotactic-radiosurgery-for-brain-tumors
#18
K Raja Muralidhar, Suresh Pangam, Srinivas Ponaganti, Jayarama Krishna, Kolla V Sujana, Priya K Komanduri
PURPOSE: 1. online verification of patient position during treatment using calypso electromagnetic localization and tracking system. 2. Verification and comparison of positional accuracy between cone beam computed tomography and calypso system. 3. Presenting the advantage of continuation localization in Stereotactic radiosurgery treatments. METHODS: Ten brain tumor cases were taken for this study. Patients with head mask were under gone Computed Tomography (CT)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046411/th-b-204-00-implanted-markers-for-radiation-therapy-and-tg-199-update
#19
Zhiheng Wang
: Implanted markers as target surrogates have been widely used for treatment verification, as they provide safe and reliable monitoring of the inter- and intra-fractional target motion. The rapid advancement of technology requires a critical review and recommendation for the usage of implanted surrogates in current field. The symposium, also reporting an update of AAPM TG 199 - Implanted Target Surrogates for Radiation Treatment Verification, will be focusing on all clinical aspects of using the implanted target surrogates for treatment verification and related issues...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046302/th-cd-bra-01-best-in-physics-therapy-field-induced-dose-effects-in-a-mouse-lung-phantom-monte-carlo-and-experimental-assessments
#20
A Rubinstein, R Tailor, A Melancon, J Pollard, M Guindani, D Followill, J Hazle, L Court
PURPOSE: To simulate and measure magnetic-field-induced radiation dose effects in a mouse lung phantom. This data will be used to support pre-clinical experiments related to MRI-guided radiation therapy systems. METHODS: A mouse lung phantom was constructed out of 1.5×1.5×2.0-cm(3) lung-equivalent material (0.3 g/cm(3) ) surrounded by a 0.6-cm solid water shell. EBT3 film was inserted into the phantom and the phantom was placed between the poles of an H-frame electromagnet...
June 2016: Medical Physics
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