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Myocardial infarction health utility

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https://www.readbyqxmd.com/read/28641023/cardiovascular-event-incidence-and-cost-in-type-2-diabetes-mellitus-a-medicare-claims-based-actuarial-analysis
#1
Kathryn Fitch, Tyler Engel, Stephen Sander, Effie Kuti, Helen Blumen
OBJECTIVE: Assess the economic burden of cardiovascular events in Medicare beneficiaries with type 2 diabetes mellitus (T2DM). METHODS: This claims-based actuarial analysis queried 2013 and 2014 Medicare 5% Samples, defining a denominator of fee-for-service beneficiaries. Average per patient per month allowed cost ($PPPM) was calculated for T2DM, demographically adjusted non-T2DM, and denominator. Per member per month allowed cost ($PMPM) was calculated by dividing total population cost by member months in the denominator...
June 22, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28635339/methods-for-estimating-costs-in-patients-with-hyperlipidemia-experiencing-their-first-cardiovascular-event-in-the-united-kingdom
#2
Mark D Danese, Michelle Gleeson, Robert I Griffiths, David Catterick, Lucie Kutikova
AIMS: Methods for integrating external costs into clinical databases are not well-characterized. The purpose of this research was to describe and implement methods for estimating the cost of hospitalizations, prescriptions, and general practitioner and specialist visits used to manage hyperlipidemia patients experiencing cardiovascular (CV) events in the United Kingdom (UK). METHODS: This study was a retrospective cohort study using the Clinical Practice Research Datalink and Hospital Episode Statistics data...
June 21, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28625371/cardiovascular-events-and-hospital-resource-utilization-pre-and-post-transcatheter-mitral-valve-repair-in-high-surgical-risk-patients
#3
Sreekanth Vemulapalli, Steven J Lippmann, Mitchell Krucoff, Adrian F Hernandez, Lesley H Curtis, Elyse Foster, Atif Qasim, Andrew Wang, Donald D Glower, Ted Feldman, Bradley G Hammill
MitraClip is an approved therapy for mitral regurgitation (MR); however, health care resource utilization pre- and post-MitraClip remains understudied. METHODS: Patients with functional and degenerative MR at high surgical risk in the EVEREST II High-Risk Registry and REALISM Continued-Access Study were linked to Medicare data. Pre- and post-MitraClip all-cause death, stroke, myocardial infarction, heart failure (HF), and bleeding hospitalizations were identified. Inpatient costs, adjusted to 2010 US dollars, were calculated, and event rate ratios and cost ratios were estimated with multivariable modeling...
July 2017: American Heart Journal
https://www.readbyqxmd.com/read/28572740/an-integrated-epidemiological-and-neural-net-model-of-the-warfarin-effect-in-managed-care-patients
#4
David M Jacobs, Filip Stefanovic, Greg Wilton, Andres Gomez-Caminero, Jerome J Schentag
INTRODUCTION: Risk assessment tools are utilized to estimate the risk for stroke and need of anticoagulation therapy for patients with atrial fibrillation (AF). These risk stratification scores are limited by the information inputted into them and a reliance on time-independent variables. The objective of this study was to develop a time-dependent neural net model to identify AF populations at high risk of poor clinical outcomes and evaluate the discriminatory ability of the model in a managed care population...
2017: Clinical Pharmacology: Advances and Applications
https://www.readbyqxmd.com/read/28554140/health-related-quality-of-life-implications-of-cardiovascular-events-in-individuals-with-type-2-diabetes-mellitus-a-subanalysis-from-the-saxagliptin-assessment-of-vascular-outcomes-recorded-in-patients-with-diabetes-mellitus-savor-timi-53-trial
#5
Andrew H Briggs, Deepak L Bhatt, Benjamin M Scirica, Itamar Raz, Karissa M Johnston, Shelagh M Szabo, Klas Bergenheim, Jayanti Mukherjee, Boaz Hirshberg, Ofri Mosenzon
BACKGROUND: The impact of cardiovascular complications on health-related quality-of-life (HRQoL) in type 2 diabetes mellitus has not been clearly established. Using EQ5D utility data from SAVOR-TIMI 53, a large phase IV trial of saxagliptin versus placebo, we quantified the impact of cardiovascular and other major events on HRQoL. METHODS: EQ5D utilities were recorded annually and following myocardial infarction (MI) or stroke. Utilities among patients experiencing major cardiovascular events were analyzed using linear mixed-effects regression, adjusting for baseline characteristics (including EQ5D utility), and compared to those not experiencing major cardiovascular events...
January 23, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28549781/nucleostemin-dysregulation-contributes-to-ischemic-vulnerability-of-diabetic-hearts-role-of-ribosomal-biogenesis
#6
Shihao Zhao, Yunlong Xia, Fuyang Zhang, Zhenyu Xiong, Yueyang Li, Wenjun Yan, Xiyao Chen, Wei Wang, Helin Wang, Erhe Gao, Yan Lee, Congye Li, Shan Wang, Ling Zhang, Ling Tao
Diabetes is a major health problem worldwide. As well-known, diabetes greatly increases cardiac vulnerability to ischemia/reperfusion (I/R) injury, but the underlying mechanisms remain elusive. Nucleostemin (NS) is a nucleolar protein that controls ribosomal biogenesis and exerts cardioprotective effects against I/R injury. However, whether NS-mediated ribosomal biogenesis regulates ischemic vulnerability of diabetic hearts remains unanswered. Utilizing myocardial I/R mouse models, we found that cardiac NS expression significantly increased in response to I/R in normal diet (ND)-fed mice...
May 23, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28496030/underuse-of-cardiac-rehabilitation-in-workers-with-coronary-artery-disease%C3%A3-claims-database-survey-in-japan
#7
Natsuko Kanazawa, Kenji Ueshima, Shinjiro Tominari, Takeo Nakayama
BACKGROUND: Workers with coronary artery disease (CAD) require evidence-based care in order to return to work safely. We assessed the use of cardiac rehabilitation (CR) among workers with CAD, and identified the factors associated with CR use.Methods and Results:A retrospective cohort study based on data from a health insurance claims database was conducted. We identified workers aged ≥18 years who underwent percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) between 2006 and 2013, and reviewed the utilization of inpatient or outpatient CR...
May 11, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28406123/utilization-of-glial-fibrillary-acidic-protein-and-galectin-3-in-the-diagnosis-of-cerebral-infarction-patients-with-normal-cranial-tomography
#8
E Ekingen, M Yilmaz, M Yildiz, M Atescelik, M C Goktekin, M Gurger, O D Alatas, M Basturk, N Ilhan
OBJECTIVE: It was aimed to determine whether levels of glial fibrillary acidic protein (GFAP) and Galectin-3 contribute to the diagnosis of cerebral infarction in clinically suspected ischemic stroke patients with normal computerized cranial tomography (CCT) in the emergency department. MATERIALS AND METHODS: In this study, patients above the age of 18 years who presented to emergency department of Firat University between December 2011-November 2012 and were diagnosed with cerebral infarction were included...
April 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28404560/statin-eligibility-and-outpatient-care-prior-to-st-segment-elevation-myocardial-infarction
#9
Michael D Miedema, Ross F Garberich, Lucas J Schnaidt, Erin Peterson, Craig Strauss, Scott Sharkey, Thomas Knickelbine, Marc C Newell, Timothy D Henry
BACKGROUND: The impact of the 2013 American College of Cardiology/American Heart Association cholesterol guidelines on statin eligibility in individuals otherwise destined to experience cardiovascular disease (CVD) events is unclear. METHODS AND RESULTS: We analyzed a prospective cohort of consecutive ST-segment elevation myocardial infarction (STEMI) patients from a regional STEMI system with data on patient demographics, low-density lipoprotein cholesterol levels, CVD risk factors, medication use, and outpatient visits over the 2 years prior to STEMI...
April 12, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28387143/diabetes-control-incidence-of-acute-myocardial-infarction-and-all-cause-mortality-among-patients-with-3-6-years-disease-duration
#10
Orna Reges, Morton Leibowitz, Moshe Hoshen, Maya Leventer-Roberts, Philip Greenland, Ran Balicer
Background Optimal glycated haemoglobin (HbA1c) concentrations to minimize large vessel complications and prolong life in diabetes patients are not well established. Design A retrospective cohort study from 2010 to 2012 using data from the Clalit Health Service (Clalit) integrated healthcare system's electronic data warehouse. Patients included had newly incident diabetes, had at least two HbA1c measurements during the 3 years prior to 1 January 2010 without any disruption(s) in Clalit membership between 2010 and 2014...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28366472/mice-or-nice-an-economic-evaluation-of-clinical-decision-rules-in-the-diagnosis-of-heart-failure-in-primary-care
#11
Mark Monahan, Pelham Barton, Clare J Taylor, Andrea K Roalfe, F D Richard Hobbs, Martin Cowie, Russell Davis, Jon Deeks, Jonathan Mant, Deborah McCahon, Theresa McDonagh, George Sutton, Lynda Tait
BACKGROUND: Detection and treatment of heart failure (HF) can improve quality of life and reduce premature mortality. However, symptoms such as breathlessness are common in primary care, have a variety of causes and not all patients require cardiac imaging. In systems where healthcare resources are limited, ensuring those patients who are likely to have HF undergo appropriate and timely investigation is vital. DESIGN: A decision tree was developed to assess the cost-effectiveness of using the MICE (Male, Infarction, Crepitations, Edema) decision rule compared to other diagnostic strategies to identify HF patients presenting to primary care...
March 2, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28361110/patterns-of-care-and-outcomes-in-cardiovascular-disease-after-kidney-transplantation-in-the-united-states
#12
Amit K Mathur, Yu-Hui Chang, D Eric Steidley, Raymond Heilman, Narjeet Khurmi, Nabil Wasif, David Etzioni, Adyr A Moss
BACKGROUND: Cardiovascular disease (CVD) is an important driver of mortality after kidney transplantation. Its broader impact on posttransplant health care utilization in US hospitals is unknown. METHODS: We used administrative claims data from the Nationwide Inpatient Sample and the American Hospital Association Annual Survey to identify hospitalizations for kidney transplant patients with a cardiovascular diagnosis from 2005 to 2011. CVD hospitalizations were stratified by transplant hospital status to characterize patterns in inpatient health care utilization and outcomes...
February 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28341926/risks-associated-with-antiretroviral-treatment-for-human-immunodeficiency-virus-hiv-qualitative-analysis-of-social-media-data-and-health-state-utility-valuation
#13
Louis S Matza, Karen C Chung, Katherine J Kim, Trena M Paulus, Evan W Davies, Katie D Stewart, Grace A McComsey, Marshall W Fordyce
PURPOSE: Despite benefits of antiretroviral therapies (ART), people with HIV infection have increased risk of cardiovascular disease, kidney disease, and low bone mineral density. Some ARTs increase risk of these events. The purpose of this study was to examine patients' perspectives of these risks and estimate health state utilities associated with these risks for use in cost-utility models. METHODS: Qualitative thematic analysis was conducted to examine messages posted to the POZ/AIDSmeds Internet community forums, focusing on bone, kidney, and cardiovascular side effects and risks of HIV/AIDS medications...
July 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28327105/association-of-physical-activity-on-body-composition-cardiometabolic-risk-factors-and-prevalence-of-cardiovascular-disease-in-the-korean-population-from-the-fifth-korea-national-health-and-nutrition-examination-survey-2008-2011
#14
Gwang-Sil Kim, Eui Im, Ji-Hyuck Rhee
BACKGROUND: Data regarding associations among physical activity (PA) level, body composition, and prevalence of cardiovascular diseases in Asian populations are rare. METHODS: The International Physical Activity Questionnaire (IPAQ) was utilized to estimate PA levels and analyze the association of PA level with various body composition parameters and the prevalence of cardiovascular diseases by using data from the Korean National Health and Nutrition Examination Survey from 2008 to 2011...
March 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28292489/the-3-year-cost-effectiveness-of-a-nurse-based-case-management-versus-usual-care-for-elderly-patients-with-myocardial-infarction-results-from-the-korinna-follow-up-study
#15
RANDOMIZED CONTROLLED TRIAL
Hildegard Seidl, Matthias Hunger, Christa Meisinger, Inge Kirchberger, Bernhard Kuch, Reiner Leidl, Rolf Holle
OBJECTIVES: To assess the 3-year cost-effectiveness of a nurse-based case management intervention in elderly patients with myocardial infarction from a societal perspective. METHODS: The intervention consisted of one home visit and quarterly telephone calls in the first year, and semi-annual calls in the following 2 years. The primary effect measures were quality-adjusted life-years (QALYs), on the basis of the EuroQol five-dimensional questionnaire (EQ-5D-3L) and adjusted life-years from patients' self-rated health states according to the visual analogue scale (VAS-ALs)...
March 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28291598/identifying-radiology-s-place-in-the-expanding-landscape-of-episode-payment%C3%A2-models
#16
Andrew B Rosenkrantz, Joshua A Hirsch, Bibb Allen, H Benjamin Harvey, Gregory N Nicola
The current fee-for-service system for health care reimbursement in the United Stated is argued to encourage fragmented care delivery and a lack of accountability that predisposes to insufficient focus on quality as well as unnecessary or duplicative resource utilization. Episode payment models (EPMs) seek to improve coordination by linking payments for all services related to a patient's condition or procedure, thereby improving quality and efficiency of care. The CMS Innovation Center has implemented a broadening array of EPMs...
March 10, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28264868/global-longitudinal-strain-by-echocardiography-predicts-long-term-risk-of-cardiovascular-morbidity-and-mortality-in-a-low-risk-general-population-the-copenhagen-city-heart-study
#17
Tor Biering-Sørensen, Sofie Reumert Biering-Sørensen, Flemming Javier Olsen, Morten Sengeløv, Peter Godsk Jørgensen, Rasmus Mogelvang, Amil M Shah, Jan Skov Jensen
BACKGROUND: Global longitudinal strain (GLS) is prognostic of adverse cardiovascular outcomes in various patient populations, but the prognostic utility of GLS for long-term cardiovascular morbidity and mortality in the general population is unknown. METHODS AND RESULTS: A total of 1296 participants in a general population study underwent a health examination, including echocardiography measurement of GLS. The primary end point was the composite of incident heart failure, acute myocardial infarction, or cardiovascular death...
March 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28214504/frequency-of-troponin-testing-in-inpatient-versus-outpatient-settings
#18
Adam J Farber, Keith Suarez, Kipp Slicker, Chhaya D Patel, Brandon Pope, Robert Kowal, Jeffrey B Michel
Troponin elevation is required to diagnose acute myocardial infarction (AMI), yet elevated values are often encountered in noncardiac disease states. We evaluated inpatient (IP) and outpatient (OP) encounters at 14 hospitals in calendar year 2014 and found that troponin assays were performed during 12% of all OP visits and 29% of all IP visits: 82,853 encounters in all. We employed an expert panel to estimate the likelihood of AMI based on primary International Statistical Classification of Diseases and Related Health Problems, 9th edition diagnoses...
April 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28178979/managed-care-and-inpatient-mortality-in-adults-effect-of-primary-payer
#19
Anika L Hines, Susan O Raetzman, Marguerite L Barrett, Ernest Moy, Roxanne M Andrews
BACKGROUND: Because managed care is increasingly prevalent in health care finance and delivery, it is important to ascertain its effects on health care quality relative to that of fee-for-service plans. Some stakeholders are concerned that basing gatekeeping, provider selection, and utilization management on cost may lower quality of care. To date, research on this topic has been inconclusive, largely because of variation in research methods and covariates. Patient age has been the only consistently evaluated outcome predictor...
February 8, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28150313/improved-outcomes-and-reduced-costs-associated-with-a-health-system-wide-patient-blood-management-program-a-retrospective-observational-study-in-four-major-adult-tertiary-care-hospitals
#20
Michael F Leahy, Axel Hofmann, Simon Towler, Kevin M Trentino, Sally A Burrows, Stuart G Swain, Jeffrey Hamdorf, Trudi Gallagher, Audrey Koay, Gary C Geelhoed, Shannon L Farmer
BACKGROUND: Patient blood management (PBM) programs are associated with improved patient outcomes, reduced transfusions and costs. In 2008, the Western Australia Department of Health initiated a comprehensive health-system-wide PBM program. This study assesses program outcomes. STUDY DESIGN AND METHODS: This was a retrospective study of 605,046 patients admitted to four major adult tertiary-care hospitals between July 2008 and June 2014. Outcome measures were red blood cell (RBC), fresh-frozen plasma (FFP), and platelet units transfused; single-unit RBC transfusions; pretransfusion hemoglobin levels; elective surgery patients anemic at admission; product and activity-based costs of transfusion; in-hospital mortality; length of stay; 28-day all-cause emergency readmissions; and hospital-acquired complications...
February 2, 2017: Transfusion
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