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https://www.readbyqxmd.com/read/28445465/assembly-of-functionally-integrated-human-forebrain-spheroids
#1
Fikri Birey, Jimena Andersen, Christopher D Makinson, Saiful Islam, Wu Wei, Nina Huber, H Christina Fan, Kimberly R Cordes Metzler, Georgia Panagiotakos, Nicholas Thom, Nancy A O'Rourke, Lars M Steinmetz, Jonathan A Bernstein, Joachim Hallmayer, John R Huguenard, Sergiu P Paşca
The development of the nervous system involves a coordinated succession of events including the migration of GABAergic (γ-aminobutyric-acid-releasing) neurons from ventral to dorsal forebrain and their integration into cortical circuits. However, these interregional interactions have not yet been modelled with human cells. Here we generate three-dimensional spheroids from human pluripotent stem cells that resemble either the dorsal or ventral forebrain and contain cortical glutamatergic or GABAergic neurons...
April 26, 2017: Nature
https://www.readbyqxmd.com/read/28444976/association-of-lipoprotein-a-with-long-term-mortality-following-coronary-angiography-or-percutaneous-coronary-intervention
#2
Zhe Feng, Hua-Long Li, Wei-Jie Bei, Xiao-Sheng Guo, Kun Wang, Shi-Xin Yi, De-Mou Luo, Xi-da Li, Shi-Qun Chen, Peng Ran, Peng-Yuan Chen, Sheikh Mohammed Shariful Islam, Ji-Yan Chen, Yong Liu, Ying-Ling Zhou
BACKGROUND: There is no consistent evidence to suggest the association of plasma lipoprotein(a) (Lp[a]) with long-term mortality in patients undergoing coronary angiography (CAG) or percutaneous coronary intervention (PCI). HYPOTHESIS: Level of Lp(a) is associated with long-term mortality following CAG or PCI. METHODS: We enrolled 1684 patients with plasma Lp(a) data undergoing CAG or PCI between April 2009 and December 2013. The patients were divided into 2 groups: a low-Lp(a) group (Lp[a] <16...
April 26, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28443122/membrane-proteomics-of-arabidopsis-glucosinolate-mutants-cyp79b2-b3-and-myb28-29
#3
Islam Mostafa, Mi-Jeong Yoo, Ning Zhu, Sisi Geng, Craig Dufresne, Maged Abou-Hashem, Maher El-Domiaty, Sixue Chen
Glucosinolates (Gls) constitute a major group of natural metabolites represented by three major classes (aliphatic, indolic and aromatic) of more than 120 chemical structures. In our previous work, soluble proteins and metabolites in Arabidopsis mutants deficient of aliphatic (myb28/29) and indolic Gls (cyp79B2B3) were analyzed. Here we focus on investigating the changes at the level of membrane proteins in these mutants. Our LC/MS-MS analyses of tandem mass tag (TMT) labeled peptides derived from the cyp79B2/B3 and myb28/29 relative to wild type resulted in the identification of 4,673 proteins, from which 2,171 are membrane proteins...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28442378/antihyperlipidemic-and-antiapoptotic-potential-of-zingerone-on-alcohol-induced-hepatotoxicity-in-experimental-rats
#4
Vijay Mani, Sivaranjani Arivalagan, Aktarul Islam Siddique, Nalini Namasivayam
The ultimate aim of this present study was to investigate the antihyperlipidemic and antiapoptotic potential of zingerone (ZO) on alcohol induced hepatotoxicity in experimental rats. Male albino wistar rats were divided in four groups. Groups 1 and 2 rats received isocaloric glucose and dimethyl sulphoxide (2% DMSO), liver toxicity was induced in groups 3 and 4 by supplementing 30% ethanol post orally for 60 days. In addition, groups 2 and 4 received zingerone (20 mg/kg body weight in 2% DMSO) daily during the final 30 days of the experimental period...
April 22, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28441571/negative-histology-with-surgically-treated-tubal-ectopic-pregnancies-a-retrospective-cohort-study
#5
Linda Farahani, Anjita Sinha, Jilly Lloyd, Melissa Islam, Jackie A Ross
OBJECTIVE: To determine the outcome of histological examinations of surgical specimens obtained from treatment of tubal ectopic pregnancy and to correlate with clinical findings, pre-operative ultrasound scans and the type of surgery. STUDY DESIGN: A retrospective cohort study of 941 women diagnosed with a tubal ectopic pregnancy in the Early Pregnancy Unit and having surgical treatment at King's College Hospital, London. Clinical and ultrasound data had been entered contemporaneously on our electronic early pregnancy database and hospital clinical records over an 11year period from 2004 to 2014...
April 2, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28438308/cardiovascular-outcomes-with-surgical-left-atrial-appendage-exclusion-in-patients-with-atrial-fibrillation-who-underwent-valvular-heart-surgery-from-the-national-inpatient-sample-database
#6
Ayman Elbadawi, Odunayo Olorunfemi, Gbolahan O Ogunbayo, Marwan Saad, Islam Y Elgendy, Zainab Arif, Haytham Badran, Deola Saheed, Hamdy M A Ahmed, Mohan Rao
Left atrial appendage (LAA) exclusion is a commonly performed procedure to reduce the embolic events in patients with atrial fibrillation (AF) who underwent cardiac surgeries. Our study aimed to evaluate the in-hospital outcomes of LAA exclusion in patients with AF who underwent valvular heart surgeries. We queried the Nationwide Inpatient Sample Database from 1998 to 2013 for patients with the International Classification of Diseases, Ninth Edition, Clinical Modification, diagnosis codes for AF and underwent any valvular heart surgery...
March 29, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28438053/scorpion-venom-causes-upregulation-of-p53-and-downregulation-of-bcl-xl-and-bid-protein-expression-by-modulating-signaling-proteins-erk-1-2-and-stat3-and-dna-damage-in-breast-and-colorectal-cancer-cell-lines
#7
Abdulrahman Khazim Al-Asmari, Anvarbatcha Riyasdeen, Mozaffarul Islam
Scorpion venoms efficiently block the normal neurotransmitter signaling pathway by prejudicing the ion channel operating mechanism in the body system. Besides its negative effect, venoms also possess some beneficial qualities for humans. They have also been shown to exhibit anticancer properties in various cancer types. This unique property of the venom as an anticancer agent is mainly a result of its role in initiating apoptosis and inhibiting several signaling cascade mechanisms that promote cancer cell proliferation and growth...
April 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28437868/early-mortality-and-overall-survival-of-acute-myeloid-leukemia-based-on-facility-type
#8
Vijaya R Bhatt, Valerie Shostrom, Smith Giri, Krishna Gundabolu, K M Monirul Islam, Frederick R Appelbaum, Lori J Maness
Cancer health disparities may exist based on the facility type. We aimed to determine the association between the academic status of centers and outcomes of patients with acute myeloid leukemia (AML). Using the National Cancer Data Base, we compared one-month mortality and longer-term overall survival (OS) of 60,738 patients with AML, who received first course treatment between 2003-2011 at academic or non-academic centers (community cancer program, comprehensive community cancer program, and others). Multivariate analysis was done using logistic regression for one-month mortality and Cox regression with backward elimination approach for OS...
April 24, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28436965/a-three-dimensional-model-of-human-lung-development-and-disease-from-pluripotent-stem-cells
#9
Ya-Wen Chen, Sarah Xuelian Huang, Ana Luisa Rodrigues Toste de Carvalho, Siu-Hong Ho, Mohammad Naimul Islam, Stefano Volpi, Luigi D Notarangelo, Michael Ciancanelli, Jean-Laurent Casanova, Jahar Bhattacharya, Alice F Liang, Laura M Palermo, Matteo Porotto, Anne Moscona, Hans-Willem Snoeck
Recapitulation of lung development from human pluripotent stem cells (hPSCs) in three dimensions (3D) would allow deeper insight into human development, as well as the development of innovative strategies for disease modelling, drug discovery and regenerative medicine. We report here the generation from hPSCs of lung bud organoids (LBOs) that contain mesoderm and pulmonary endoderm and develop into branching airway and early alveolar structures after xenotransplantation and in Matrigel 3D culture. Expression analysis and structural features indicated that the branching structures reached the second trimester of human gestation...
April 24, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28436345/evidence-that-polygenic-risk-for-psychotic-disorder-is-expressed-in-the-domain-of-neurodevelopment-emotion-regulation-and-attribution-of-salience
#10
J van Os, Y van der Steen, Md A Islam, S Gülöksüz, B P Rutten, C J Simons
BACKGROUND: The liability-threshold model of psychosis risk predicts stronger phenotypic manifestation of the polygenic risk score (PRS) in the healthy relatives of patients, as compared with healthy comparison subjects. METHODS: First-degree relatives of patients with psychotic disorder (871 siblings and 812 parents) and healthy comparison subjects (n = 523) were interviewed three times in 6 years. Repeated measures of two psychosis phenotypes, the Community Assessment of Psychic Experiences (CAPE; self-report - subscales of positive, negative and depressive symptoms) and the Structured Interview for Schizotypy - Revised (SIS-R; clinical interview - subscales of positive and negative schizotypy), were examined for association with PRS...
April 24, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28435813/medical-care-or-disciplinary-discourses-preventive-measures-against-the-black-death-in-late-medieval-paris-a-brief-review
#11
REVIEW
Yong Jin Hong, Sam Hun Park
BACKGROUND: This paper examined the political and social implications of the Compendium de epidemia prescription written by the Masters of the Faculty of Medicine of the University of Paris in the mid-14th century during the Black Death. This study aimed to examine how the effects of power as a discourse owned by medical knowledge are revealed. METHODS: This paper outlines the composition of the contents based on the 1888 edition edited and translated by Émile H...
March 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28435031/clinical-outcome-associated-with-the-use-of-different-inhalation-method-with-and-without-humidification-in-asthmatic-mechanically-ventilated-patients
#12
Islam O F Moustafa, Muhammad H E ElHansy, Moataz Al Hallag, James B Fink, Patricia Dailey, Hoda Rabea, Mohamed E A Abdelrahim
BACKGROUND: Inhaled-medication delivered during mechanical-ventilation is affected by type of aerosol-generator and humidity-condition. Despite many in-vitro studies related to aerosol-delivery to mechanically-ventilated patients, little has been reported on clinical effects of these variables. The aim of this study was to determine effect of humidification and type of aerosol-generator on clinical status of mechanically ventilated asthmatics. METHOD: 72 (36 females) asthmatic subjects receiving invasive mechanical ventilation were enrolled and assigned randomly to 6 treatment groups of 12 (6 females) subjects each received, as possible, all inhaled medication using their assigned aerosol generator and humidity condition during delivery...
April 20, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28433737/exploring-biochemical-pathways-for-mono-ethylene-glycol-meg-synthesis-from-synthesis-gas
#13
M Ahsanul Islam, Noushin Hadadi, Meric Ataman, Vassily Hatzimanikatis, Gregory Stephanopoulos
Mono-ethylene glycol (MEG) is an important petrochemical with widespread use in numerous consumer products. The current industrial MEG-production process relies on non-renewable fossil fuel-based feedstocks, such as petroleum, natural gas, and naphtha; hence, it is useful to explore alternative routes of MEG-synthesis from gases as they might provide a greener and more sustainable alternative to the current production methods. Technologies of synthetic biology and metabolic engineering of microorganisms can be deployed for the expression of new biochemical pathways for MEG-synthesis from gases, provided that such promising alternative routes are first identified...
April 19, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/28433680/organocatalyzed-and-mechanochemical-solvent-free-synthesis-of-novel-and-functionalized-bis-biphenyl-substituted-thiazolidinones-as-potent-tyrosinase-inhibitors-sar-and-molecular-modeling-studies
#14
Sadaf Mutahir, Muhammad Asim Khan, Islam Ullah Khan, Muhammad Yar, Muhammad Ashraf, Sidra Tariq, Ren-Long Ye, Bao-Jing Zhou
Eluding the involvement of solvents in organic synthesis and introducing environment friendly procedures can control environmental problems. A facile and an efficient solvent free mechanochemical method (grinding) is achieved to synthesize novel bis-biphenyl substituted thiazolidinones using non-toxic and cheap N-acetyl glycine (NAG). Organocatalytic condensation of a series of Schiff's bases bearing different substituents with thioglycolic acid produces a variety of thiazolidinones derivatives in good to excellent yield...
April 13, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28432350/enhancing-the-throughput-and-multiplexing-capabilities-of-next-generation-sequencing-for-efficient-implementation-of-pooled-shrna-and-crispr-screens
#15
Md Fahmid Islam, Atsushi Watanabe, Lai Wong, Conor Lazarou, Frederick S Vizeacoumar, Omar Abuhussein, Wayne Hill, Maruti Uppalapati, C Ronald Geyer, Franco J Vizeacoumar
Next generation sequencing is becoming the method of choice for functional genomic studies that use pooled shRNA or CRISPR libraries. A key challenge in sequencing these mixed-oligo libraries is that they are highly susceptible to hairpin and/or heteroduplex formation. This results in polyclonal, low quality, and incomplete reads and reduces sequencing throughput. Unfortunately, this challenge is significantly magnified in low-to-medium throughput bench-top sequencers as failed reads significantly perturb the maximization of sequence coverage and multiplexing capabilities...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28431645/lopez-pm-islam-n-feinberg-a-myers-c-seidl-l-drackett-e-riley-l-mata-a-pinzon-j-benjamin-e-wyka-k-dannefer-r-lopez-j-trinh-shevrin-c-maybank-ka-thorpe-le-a-place-based-community-health-worker-program-feasibility-and-early-outcomes-new-york-city-2015-am-j-prev
#16
https://www.readbyqxmd.com/read/28430216/ultrahigh-birefringence-ultralow-material-loss-porous-core-single-mode-fiber-for-terahertz-wave-guidance
#17
Kawsar Ahmed, Sawrab Chowdhury, Bikash Kumar Paul, Md Shadidul Islam, Shuvo Sen, Md Ibadul Islam, Sayed Asaduzzaman
In this paper, a novel polarization-maintaining single-mode photonic crystal fiber (PCF) has been suggested for terahertz (THz) transmission applications. The reported PCF has five layers of hexagonal cladding with two layers of porous core. The cladding and core territory of the PCF are constituted by circular and elliptical air cavities, accordingly acting as a dielectric medium. Different geometrical parameters of the proposed PCF including pitches and diameters of circular air holes with the major and minor axes of elliptical air cavities being varied with the optimized structure...
April 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28430077/host-pathogen-interactions-modulated-by-small-rnas
#18
Waqar Islam, Zujian Wu, Saif Ul Islam
Biological processes such as defense mechanisms and microbial offence strategies are regulated through RNA induced interference in eukaryotes. Genetic mutations are modulated through biogenesis of small RNAs which directly impacts upon host development. Plant defense mechanisms are regulated and supported by a diversified group of small RNAs which are involved in streamlining several RNA interference pathways leading towards the initiation of pathogen gene silencing mechanisms. In the similar context, pathogens also utilize the support of small RNAs to launch their offensive attacks...
April 21, 2017: RNA Biology
https://www.readbyqxmd.com/read/28427484/racial-and-ethnic-subgroup-disparities-in-hypertension-prevalence-new-york-city-health-and-nutrition-examination-survey-2013-2014
#19
Kezhen Fei, Jesica S Rodriguez-Lopez, Marcel Ramos, Nadia Islam, Chau Trinh-Shevrin, Stella S Yi, Claudia Chernov, Sharon E Perlman, Lorna E Thorpe
INTRODUCTION: Racial/ethnic minority adults have higher rates of hypertension than non-Hispanic white adults. We examined the prevalence of hypertension among Hispanic and Asian subgroups in New York City. METHODS: Data from the 2013-2014 New York City Health and Nutrition Examination Survey were used to assess hypertension prevalence among adults (aged ≥20) in New York City (n = 1,476). Hypertension was measured (systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg or self-reported hypertension and use of blood pressure medication)...
April 20, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28426035/hierarchical-bioi-nanostructures-supported-on-a-metal-organic-framework-as-efficient-photocatalysts-for-degradation-of-organic-pollutants-in-water
#20
M Jahurul Islam, Hyun Kook Kim, D Amaranatha Reddy, Yujin Kim, Rory Ma, Heehyun Baek, Joonghan Kim, Tae Kyu Kim
Semiconductor-based photocatalysis is a green method for the removal of toxic organic pollutants by decomposition into harmless products. However, traditional single-component semiconductors are unable to reach high degradation efficiencies due to excessive photo charge carrier recombination. The use of hybrid nanocomposite photocatalysts is a promising strategy for overcoming this problem by reducing recombination as well as ensuring that large amounts of solar energy are harvested. Herein, a novel visible-light-active hybrid nanocomposite, BiOI/MIL-88B(Fe), was successfully synthesized through a simple precipitation method...
April 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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