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Takayuki Iwamoto, Yasuharu Imai, Sachiyo Kogita, Takumi Igura, Yoshiyuki Sawai, Kazuto Fukuda, Yoshitaka Yamaguchi, Yasushi Matsumoto, Masanori Nakahara, Osakuni Morimoto, Yasushi Seki, Hiroshi Ohashi, Norihiko Fujita, Masatoshi Kudo, Tetsuo Takehara
OBJECTIVE: We compared the efficacy of contrast-enhanced ultrasound sonography (CEUS) with sonazoid and gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI for the assessment of macroscopic classification of nodular hepatocellular carcinoma (HCC). METHODS: Seventy-seven consecutive patients with 79 surgically resected HCCs who underwent both preoperative CEUS and Gd-EOB-DTPA-enhanced MRI were enrolled in this retrospective study...
2016: Digestive Diseases
Jeong Woo Kim, Chang Hee Lee, Soo Byn Kim, Bit Na Park, Yang Shin Park, Jongmee Lee, Cheol Min Park
PURPOSE: To identify the most reliable imaging features for differentiating hepatocellular carcinoma with paradoxical uptake on the hepatobiliary phase (HCCpara ) from focal nodular hyperplasia (FNH)-like nodules using Gd-EOB-DTPA-enhanced MRI. MATERIALS AND METHODS: This was a retrospective study. Twenty patients with HCCpara and 21 patients with FNH-like nodules were included. The following MRI features were evaluated using 3.0 Tesla unit by two radiologists: signal intensity (SI) on T1-, T2-, and diffusion-weighted imaging (DWI), arterial enhancement pattern, washout appearance on the portal venous phase (PVP) and/or transitional phase (TP), uptake pattern on the hepatobiliary phase (HBP), "T2 scar," "EOB scar," and chemical shift on in- and out-of-phase images...
October 11, 2016: Journal of Magnetic Resonance Imaging: JMRI
Larry Cai, Benjamin M Yeh, Antonio C Westphalen, John Roberts, Zhen J Wang
PURPOSE: To investigate whether the addition of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced 3D T1-weighted MR cholangiography (T1w-MRC) to 3D T2-weighted MRC (T2w-MRC) improves the confidence and diagnostic accuracy of biliary anatomy in living liver donors. METHODS: Two abdominal radiologists retrospectively and independently reviewed pre-operative MR studies in 58 consecutive living liver donors. The second-order bile duct visualization on T1w- and T2w-MRC images was rated on a 4-point scale...
October 7, 2016: Abdominal Radiology
Anna Schweifer, Florian Maier, Walter Ehrlichmann, Denis Lamparter, Manfred Kneilling, Bernd J Pichler, Friedrich Hammerschmidt, Gerald Reischl
INTRODUCTION: Radiolabeled 2-nitroimidazoles (azomycins) are a prominent class of biomarkers for PET imaging of hypoxia. [(18)F]Fluoro-azomycin-α-arabinoside ([(18)F]FAZA) - already in clinical use - may be seen as α-configuration nucleoside, but enters cells only via diffusion and is not transported by cellular nucleoside transporters. To enhance image contrast in comparison to [(18)F]FAZA our objective was to (18)F-radiolabel an azomycin-2´-deoxyriboside with β-configuration ([(18)F]FAZDR, [(18)F]-β-8) to mimic nucleosides more closely and comparatively evaluate it versus [(18)F]FAZA...
August 9, 2016: Nuclear Medicine and Biology
Thomas D Vreugdenburg, Ning Ma, Joanna K Duncan, Dagmara Riitano, Alun L Cameron, Guy J Maddern
PURPOSE: This systematic review evaluated the diagnostic accuracy and impact on patient management of hepatocyte-specific gadoxetic acid enhanced magnetic resonance imaging (GA-MRI) compared to contrast enhanced computed tomography (CE-CT) in patients with liver metastases. METHOD: Four biomedical databases (PubMed, EMBASE, Cochrane Library, York CRD) were searched from January 1991 to February 2016. Studies investigating the accuracy or management impact of GA-MRI compared to CE-CT in patients with known or suspected liver metastases were included...
November 2016: International Journal of Colorectal Disease
X Sun, L Xing, S Yan, J Yu, X Dong, S Yuan, D Wang, L Bu, Z Lu, X Jiang, G Cao
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
R Toya, Y Fukugawa, T Namimoto, T Saito, H Yuki, T Matsuyama, O Ikeda, Y Yamashita, N Oya
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Vincenza Granata, Marco Cascella, Roberta Fusco, Nicoletta dell'Aprovitola, Orlando Catalano, Salvatore Filice, Vincenzo Schiavone, Francesco Izzo, Arturo Cuomo, Antonella Petrillo
Background and Purpose. Contrast media (CM) for magnetic resonance imaging (MRI) may determine the development of acute adverse reactions. Objective was to retrospectively assess the frequency and severity of adverse reactions associated with gadolinium-based contrast agents (GBCAs) injection in patients who underwent MRI. Material and Methods. At our center 10608 MRI examinations with CM were performed using five different GBCAs: Gd-BOPTA (MultiHance), Gd-DTPA (Magnevist), Gd-EOBDTPA (Primovist), Gd-DOTA (Dotarem), and Gd-BTDO3A (Gadovist)...
2016: BioMed Research International
Gustavo Felipe Luersen, W Wei, Eric P Tamm, Priya R Bhosale, Janio Szklaruk
PURPOSE: Our aim was to compare the interobserver and intraobserver variability for the measurement of the size of liver metastases in patients with carcinoid tumors with various magnetic resonance (MR) series. MATERIALS AND METHODS: In this retrospective institutional review board-approved study, 30 patients with liver metastases from a carcinoid primary had a complete MR examination of the abdomen at 1.5 T with gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)...
September 2016: Journal of Computer Assisted Tomography
Chase Constant, Silke Hecht, Linden E Craig, Cassie N Lux, Claire M Cannon, Gordon A Conklin
Hepatocellular carcinoma is the most common primary hepatic tumor in dogs and is amenable to surgical resection in many cases. Unfortunately, overlap of sonographic findings between benign and malignant hepatic lesions typically requires more invasive diagnostic tests to be performed (e.g., biopsy for histopathology). The availability of a noninvasive diagnostic test to identify hepatocellular carcinoma would be beneficial. The use of a liver-specific magnetic resonance imaging (MRI) contrast agent such as gadoxetate disodium (Gd-EOB-DTPA; Eovist® or Primovist®) has improved lesion detection in human patients...
September 15, 2016: Veterinary Radiology & Ultrasound
Youwen Xu, Sung Won Kim, Dohyun Kim, David Alexoff, Michael J Schueller, Joanna S Fowler
A rapid, mild radiosynthesis of freebase [(11)C]nicotine was developed by the methylation of freebase nornicotine with [(11)C]methyl triflate in acetone (5min, 45°C). A basic (pH 10.5-11.0) HPLC system reproducibly yielded freebase [(11)C]nicotine as a well-defined single peak. The freebase [(11)C]nicotine was concentrated by solid phase extraction and formulated in 50µL ethanol (370MBq/50µL) without evaporative loss suitable for a cigarette spiking study. A radiochemical yield of 60.4±4.7% (n=3), radiochemical purity ≥99...
August 29, 2016: Applied Radiation and Isotopes
Julia Greiser, Tobias Niksch, Wolfgang Weigand, Martin Freesmeyer
We demonstrate a method for the isolation of EOB-DTPA (3,6,9-triaza-3,6,9-tris(carboxymethyl)-4-(ethoxybenzyl)-undecanedioic acid) from its Gd(III) complex and protocols for the preparation of its novel non-radioactive, i.e., natural Ga(III) as well as radioactive (68)Ga complex. The ligand as well as the Ga(III) complex were characterized by nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry and elemental analysis. (68)Ga was obtained by a standard elution method from a (68)Ge/(68)Ga generator...
2016: Journal of Visualized Experiments: JoVE
Shinichi Nakamura, Takeshi Nakaura, Masafumi Kidoh, Kazuo Awai, Tomohiro Namimoto, Ichiro Yoshinaka, Kazunori Harada, Yasuyuki Yamashita
PURPOSE: To investigate the efficacy of the projection onto convex sets (POCS) algorithm at Gd-EOB-DTPA-enhanced hepatobiliary-phase MRI. METHODS: In phantom study, we scanned a phantom and obtained images by conventional means (P1 images), by partial-Fourier image reconstruction (PF, P2 images) and by PF with the POCS algorithm (P3 images). Then we acquired and compared subtraction images (P2-P1 images and P3-P1 images). In clinical study, 55 consecutive patients underwent Gd-EOB-DTPA (EOB)-enhanced 3D hepatobiliary-phase MRI on a 1...
2016: SpringerPlus
Krishna Juluru, Andrew H Talal, Rhonda K Yantiss, Pascal Spincemaille, Elizabeth K Weidman, Ashley E Giambrone, Sadaf Jalili, Steven P Sourbron, Jonathan P Dyke
PURPOSE: To assess the diagnostic accuracy of intracellular uptake rates (Ki ), and other quantitative pharmacokinetic (PK) parameters, for hepatic fibrosis stage; to compare this accuracy with a previously published semiquantitative metric, contrast enhancement index (CEI); and to assess variability of these parameters between liver regions. MATERIALS AND METHODS: This was a case-control study design. Dynamic Gd-EOB-DTPA-enhanced 1.5T magnetic resonance imaging (MRI) was performed prospectively in 22 subjects with varying known stages of hepatic fibrosis...
August 16, 2016: Journal of Magnetic Resonance Imaging: JMRI
Zhenpeng Peng, Mengjie Jiang, Huasong Cai, Tao Chan, Zhi Dong, Yanji Luo, Zi-Ping Li, Shi-Ting Feng
BACKGROUND: Variable degrees of differentiation in hepatocellular carcinoma(HCC)under Edmondson-Steiner grading system has been proven to be an independent prognostic indicator for HCC. Up till now, there has been no effective radiological method that can reveal the degree of differentiation in HCC before surgery. This paper aims to evaluate the use of Gd-EOB-DTPA-Enhanced Magnetic Resonance Imaging combined with T1 mapping for the diagnosis of HCC and assessing its degree of differentiation...
2016: BMC Cancer
Jeong Hee Yoon, Joon-Il Choi, Yong Yeon Jeong, Andrea Schenk, Longquan Chen, Hendrik Laue, So Yeon Kim, Jeong Min Lee
BACKGROUND & AIMS: This study aimed to determine whether the predicted remnant liver function on dynamic hepatocyte-specific contrast media-enhanced magnetic resonance (DHCE-MR) imaging correlates with the results of the indocyanin green retention test (ICG R15) after hepatic resection or radiofrequency ablation (RFA). METHODS: This prospective multicenter study was approved by the Institutional Review Boards of each hospital. Informed consents were obtained from all...
July 28, 2016: Journal of Hepatology
Ijin Joo, Jeong Min Lee, Dong Ho Lee, Su Joa Ahn, Eun Sun Lee, Joon Koo Han
PURPOSE: To investigate the Liver Imaging Reporting and Data System (LI-RADS) v2014 categorization of hepatocellular carcinomas (HCCs) on gadoxetic acid-enhanced magnetic resonance imaging (Gd-EOB-MRI) in comparison with multiphasic multidetector computed tomography (MDCT). MATERIALS AND METHODS: Our Institutional Review Board approved this retrospective study and waived the requirement for informed consent. We included 182 high-risk patients with 216 pathologically confirmed HCCs who underwent both Gd-EOB-MRI at 1...
July 30, 2016: Journal of Magnetic Resonance Imaging: JMRI
Katsuyuki Minegishi, Kotaro Nagatsu, Masami Fukada, Hisashi Suzuki, Tomoyuki Ohya, Ming-Rong Zhang
We produced (43)Sc and (47)Sc via the (nat/44)Ca(α,x)-channel using a vertical beam coupled with a ceramic target box. After activation, the powdery CaO target material was dissolved in HCl in the target box in situ and remotely recovered as a radio-Sc solution. The respective yields of (43)Sc and (47)Sc following isolation via a precipitation method with a typical 0.22µm sterile filter were 54.8MBq/µAh (1.48mCi/µAh) and 780kBq/µAh (21.1µCi/µAh) at the end of separation (approximately 1.5h from the EOB)...
October 2016: Applied Radiation and Isotopes
Gou Ogasawara, Yusuke Inoue, Keiji Matsunaga, Kaoru Fujii, Hirofumi Hata, Yuki Takato
PURPOSE: Image non-uniformity may cause substantial problems in magnetic resonance (MR) imaging especially when a 3-T scanner is used. We evaluated the effect of image non-uniformity correction in gadolinium ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MR imaging using a 3-T scanner. METHODS: Two commercially available methods for image non-uniformity correction, surface coil intensity correction (SCIC), and phased-array uniformity enhancement (PURE), were applied to Gd-EOB-DTPA-enhanced images acquired at 3-T in 20 patients...
July 5, 2016: Magnetic Resonance in Medical Sciences: MRMS
Masahiro Tanaka, Yoji Kishi, Minoru Esaki, Satoshi Nara, Mototaka Miyake, Nobuyoshi Hiraoka, Masato Nagino, Kazuaki Shimada
BACKGROUND: Gadoxetic acid-enhanced magnetic resonance imaging (MRI) in combination with diffusion-weighted MRI (Gd-EOB-MRI/DWI) has become popular for evaluating colorectal liver metastases (CRLM). This retrospective observational study aimed to determine whether this procedure should be indicated prior to hepatectomy in all patients with CRLM. METHODS: A retrospective survey of relevant data of patients who had undergone hepatectomy for CRLM from 2008 to 2014 was performed...
June 29, 2016: Annals of Surgical Oncology
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