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https://www.readbyqxmd.com/read/29771954/preoperative-prediction-of-microvascular-invasion-of-hepatocellular-carcinoma-with-ivim-diffusion-weighted-mr-imaging-and-gd-eob-dtpa-enhanced-mr-imaging
#1
Wei Zhao, Wenguang Liu, Huaping Liu, Xiaoping Yi, Jiale Hou, Yigang Pei, Hui Liu, Deyun Feng, Liyu Liu, Wenzheng Li
Microvascular invasion (MVI) is regarded as one of the independent risk factors for recurrence and poor prognosis of hepatocellular carcinoma (HCC). The presence of MVI in HCCs was evaluated on the basis of pathological reports of surgical specimens and was defined as tumor within a vascular space lined by endothelium that was visible only on microscopy. The aim of the study was to investigate the usefulness of intravoxel incoherent motion (IVIM) diffusion weighted (DW) magnetic resonance (MR) imaging in predicting MVI of HCC...
2018: PloS One
https://www.readbyqxmd.com/read/29760545/quantitative-assessment-of-hepatic-fibrosis-in-chronic-hepatitis-b-and-c-t1-mapping-on-gd-eob-dtpa-enhanced-liver-magnetic-resonance-imaging
#2
Shen Pan, Xiao-Qi Wang, Qi-Yong Guo
AIM: To assess the accuracy of Look-Locker on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) for staging liver fibrosis in chronic hepatitis B/C (CHB/C). METHODS: We prospectively included 109 patients with CHB or CHC who underwent a 3.0-Tesla MRI examination, including T1-weighted and Look-Locker sequences for T1 mapping. Hepatocyte fractions (HeF) and relaxation time reduction rate (RE) were measured for staging liver fibrosis...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29713782/gd-eob-dtpa-enhanced-mri-for-quantitative-assessment-of-liver-organ-damage-after-partial-hepatic-ischaemia-reperfusion-injury-correlation-with-histology-and-serum-biomarkers-of-liver-cell-injury
#3
Tobias Getzin, Faikah Gueler, Björn Hartleben, Marcel Gutberlet, Anja Thorenz, Rongjun Chen, Martin Meier, Jan Hinrich Bräsen, Thorsten Derlin, Dagmar Hartung, Hannah A S Lang, Hermann Haller, Frank Wacker, Song Rong, Katja Hueper
OBJECTIVE: To evaluate Gd-EOB-DTPA-enhanced MRI for quantitative assessment of liver organ damage after hepatic ischaemia reperfusion injury (IRI) in mice. METHODS: Partial hepatic IRI was induced in C57Bl/6 mice (n = 31) for 35, 45, 60 and 90 min. Gd-EOB-DTPA-enhanced MRI was performed 1 day after surgery using a 3D-FLASH sequence. A subgroup of n = 9 animals with 60 min IRI underwent follow-up with MRI and histology 7 days after IRI. The total liver volume was determined by manual segmentation of the entire liver...
April 30, 2018: European Radiology
https://www.readbyqxmd.com/read/29713251/assessment-of-liver-function-using-pharmacokinetic-parameters-of-gd-eob-dtpa-experimental-study-in-rat-hepatectomy-model
#4
Myung-Won You, Hyoung Jung Kim, Hyeong-Seok Lim, So Yeon Kim, Jae Ho Byun, Kyung Won Kim, Dae Wook Hwang, Young-Joo Lee
Objectives: To determine whether the pharmacokinetic parameters of Gd-EOB-DTPA can identify the difference in liver function in a rat hepatectomy model. Methods: A total of 56 eight-week-old male Sprague-Dawley rats were divided into the following groups: control group without hepatectomy ( n = 16), 70% hepatectomy group ( n = 14), and 90% hepatectomy group ( n = 26). On postoperative day 2, Gd-EOB-DTPA (0.1 mmol/kg) was injected intravenously and serial blood samples were obtained...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29704934/liver-enhancement-in-healthy-dogs-after-gadoxetic-acid-administration-during-dynamic-contrast-enhanced-magnetic-resonance-imaging
#5
P Borusewicz, E Stańczyk, K Kubiak, J Spużak, K Glińska-Suchocka, M Jankowski, J Nicpoń, P Podgórski
Dynamic contrast enhanced (DCE)-magnetic resonance imaging (MRI) consists of acquisition of native baseline images, followed by a series of acquisitions performed during and after administration of a contrast medium. DCE-MRI, in conjunction with hepatobiliary-specific contrast media, such as gadoxetic acid (GD-EOB-DTPA), allows for precise characterisation of the enhancement pattern of the hepatic parenchyma following administration of the contrast agent. The aim of the study was to assess the pattern of temporal resolution contrast enhancement of the hepatic parenchyma following administration of GD-EOB-DTPA and to determine the optimal time window for post-contrast assessment of the liver...
May 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29685552/coefficient-of-variation-on-gd-eob-mr-imaging-correlation-with-the-presence-of-early-stage-hepatocellular-carcinoma-in-patients-with-chronic-hepatitis-b
#6
Jung Hun Lee, Youe Ree Kim, Guy Mok Lee, Jong Hyun Ryu, Eun Young Cho, Young Hwan Lee, Kwon-Ha Yoon
PURPOSE: To study whether the measurement of hepatic fibrosis on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) magnetic resonance (MR) imaging using the coefficient of variation (CV) might be correlated with the presence of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). MATERIALS AND METHODS: This study included 104 patients with and without CHB, who were divided into 4 groups: control group, CHB without liver cirrhosis (LC; Group I), CHB with LC (Group II), and CHB with LC and HCC (Group III)...
May 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29670136/detecting-liver-fibrosis-with-gd-eob-dtpa-enhanced-mri-a-confirmatory-study
#7
Niklas Verloh, Kirsten Utpatel, Michael Haimerl, Florian Zeman, Lukas Beyer, Claudia Fellner, Frank Brennfleck, Marc H Dahlke, Christian Stroszczynski, Matthias Evert, Philipp Wiggermann
Strong correlations between the grade of fibrosis and cirrhosis, classified using the Ishak scoring system, and the uptake characteristics of Gd-EOB-DTPA with the relative enhancement (RE) of the liver parenchyma have been reported. To confirm the results of a retrospective analysis, patients undergoing liver surgery were prospectively examined with Gd-EOB-DTPA-enhanced liver 3 Tesla MRI to determine the degree of liver fibrosis. Correlations between the grade of fibrosis and cirrhosis, classified using the Ishak scoring system, and RE were investigated and compared with those derived from an initial retrospective study...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29661535/synthesis-of-carbon-11-labeled-5-ht-6-r-antagonists-as-new-candidate-pet-radioligands-for-imaging-of-alzheimer-s-disease
#8
Xiaohong Wang, Fugui Dong, Caihong Miao, Wei Li, Min Wang, Mingzhang Gao, Qi-Huang Zheng, Zhidong Xu
Carbon-11-labeled serotonin (5-hydroxytryptamine) 6 receptor (5-HT6 R) antagonists, 1-[(2-bromophenyl)sulfonyl]-5-[11 C]methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole (O-[11 C]2a) and 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-[11 C]methyl-1-piperazinyl)methyl]-1H-indole (N-[11 C]2a), 5-[11 C]methoxy-3-((4-methylpiperazin-1-yl)methyl)-1-(phenylsulfonyl)-1H-indole (O-[11 C]2b) and 5-methoxy-3-((4-[11 C]methylpiperazin-1-yl)methyl)-1-(phenylsulfonyl)-1H-indole (N-[11 C]2b), 1-((4-isopropylphenyl)sulfonyl)-5-[11 C]methoxy-3-((4-methylpiperazin-1-yl)methyl)-1H-indole (O-[11 C]2c) and 1-((4-isopropylphenyl)sulfonyl)-5-methoxy-3-((4-[11 C]methylpiperazin-1-yl)methyl)-1H-indole (N-[11 C]2c), 1-((4-fluorophenyl)sulfonyl)-5-[11 C]methoxy-3-((4-methylpiperazin-1-yl)methyl)-1H-indole (O-[11 C]2d) and 1-((4-fluorophenyl)sulfonyl)-5-methoxy-3-((4-[11 C]methylpiperazin-1-yl)methyl)-1H-indole (N-[11 C]2d), were prepared from their O- or N-desmethylated precursors with [11 C]CH3 OTf through O- or N-[11 C]methylation and isolated by HPLC combined with SPE in 40-50% radiochemical yield, based on [11 C]CO2 and decay corrected to end of bombardment (EOB)...
April 7, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29628324/synthesis-and-preliminary-biological-evaluation-of-a-novel-p2x7r-radioligand-18-f-iur-1601
#9
Mingzhang Gao, Min Wang, Barbara E Glick-Wilson, Jill A Meyer, Jonathan S Peters, Paul R Territo, Mark A Green, Gary D Hutchins, Hamideh Zarrinmayeh, Qi-Huang Zheng
The reference standard IUR-1601 ((S)-N-(2-chloro-3-(trifluoromethyl)benzyl)-1-(2-fluoroethyl)-5-oxopyrrolidine-2-carboxamide) was synthesized from tert-butyl (S)-5-oxopyrrolidine-2-carboxylate, fluoroethylbromide, and 2-chloro-3-(trifluoromethyl)benzylamine with overall chemical yield 12% in three steps. The target tracer [18 F]IUR-1601 ((S)-N-(2-chloro-3-(trifluoromethyl)benzyl)-1-(2-[18 F]fluoroethyl)-5-oxopyrrolidine-2-carboxamide) was synthesized from desmethyl-GSK1482160 with 2-[18 F]fluoroethyl tosylate, prepared from 1,2-ethylene glycol-bis-tosylate and K[18 F]F/Kryptofix2...
March 17, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29606926/prediction-of-microvascular-invasion-in-hepatocellular-carcinoma-preoperative-gd-eob-dtpa-dynamic-enhanced-mri-and-histopathological-correlation
#10
Mengqi Huang, Bing Liao, Ping Xu, Huasong Cai, Kun Huang, Zhi Dong, Ling Xu, Zhenpeng Peng, Yanji Luo, Keguo Zheng, Baogang Peng, Zi-Ping Li, Shi-Ting Feng
Objective: To investigate the imaging features observed in preoperative Gd-EOB-DTPA-dynamic enhanced MRI and correlated with the presence of microvascular invasion (MVI) in hepatocellular carcinoma (HCC) patients. Methods: 66 HCCs in 60 patients with preoperative Gd-EOB-DTPA-dynamic enhanced MRI were retrospectively analyzed. Features including tumor size, signal homogeneity, tumor capsule, tumor margin, peritumor enhancement during mid-arterial phase, peritumor hypointensity during hepatobiliary phase, signal intensity ratio on DWI and apparent diffusion coefficients (ADC), T1 relaxation times, and the reduction rate between pre- and postcontrast enhancement images were assessed...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29572174/entire-orifice-blocking-assisted-microsurgical-treatment-clipping-of-intracranial-giant-wide-neck-paraclinoid-aneurysms
#11
Ruiqi Chen, Rui Guo, Dingke Wen, Chao You, Lu Ma
OBJECTIVE: Giant wide-neck paraclinoid aneurysms remain a formidable challenge for neurosurgeons due to the brisk retrograde blood flow during surgical clipping. Theoretically, Entire orifice blockade (EOB) by placing a longitudinal intracarotid balloon catheter across the aneurysm neck could achieve a good vascular control in treating cerebral aneurysms, but related studies have been scarce. The aim of this study was to evaluate the safety and efficiency of the EOB-assisted microsurgical technique for treating giant wide-neck paraclinoid aneurysms...
March 20, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29571068/robust-high-yield-1-tbq-production-of-cyclotron-based-sodium-99m-tc-pertechnetate
#12
J D Andersson, B Thomas, S V Selivanova, E Berthelette, J S Wilson, A J B McEwan, K Gagnon
This paper presents the irradiation and processing of high-current100 Mo targets at the University of Alberta (UofA) in a GMP compliant setting. For purpose of comparison with a second production facility, additional studies at Centre Hospitalier Universitaire de Sherbrooke (CHUS) are also described. INTRODUCTION: More than 70% of today's diagnostic radiopharmaceuticals are based on99m Tc, however the conventional supply chain for obtaining99m Tc is fragile. The aim of this work was to demonstrate reliable high yield production and processing of99m Tc with medium-energy, high-current, cyclotrons...
March 2, 2018: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29562094/evaluation-of-jeffamine%C3%A2-core-pamam-dendrimers-for-simultaneous-removal-of-divalent-heavy-metal-ions-from-aqueous-solutions-by-polymer-assisted-ultrafiltration
#13
Ali Serol Ertürk, Mustafa Ulvi Gürbüz, Metin Tülü, Abdürrezzak Emin Bozdoğan
Different generations (G3-G4) of amine-terminated Jeffamine® T-403 core poly(amidoamine) PAMAM dendrimers (JCPDs) were used as new macromolecular heavy metal chelating agent templates in polymer assisted ultrafiltration (PAUF) for the investigation of their removal ability for some of the divalent metal ions: Cu, Co, Ni, Cd, and Zn from aqueous solutions under competitive conditions. The effects of pH and generation size of JCPDs were also investigated. Extent of binding (EOB) data can be appropriately expressed by a tetradentate coordination for JCPDs at pH 9 where the maximum removal of metal ions was observed...
March 2018: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/29546493/evolution-of-indeterminate-hepatocellular-nodules-at-gd-eob-dpta-enhanced-mri-in-cirrhotic-patients
#14
Massimo Galia, Francesco Agnello, Gianvincenzo Sparacia, Domenica Matranga, Domenico Albano, Massimo Midiri, Roberto Lagalla
PURPOSE: To retrospectively analyze the evolution of indeterminate hepatocellular nodules in cirrhotic patients on serial Gd-EOB-DPTA-enhanced MRI, and to identify predictors of HCC development. MATERIALS AND METHODS: This IRB approved study included 33 cirrhotic patients with 69 indeterminate hepatocellular nodules (mean diameter 1.1 cm) at baseline Gd-EOB-DPTA-enhanced MRI and a Gd-EOB-DPTA-enhanced-MRI follow-up of at least 2 years. Two radiologists evaluated size and signal intensity of each nodule at baseline and follow-up...
March 15, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29542017/correction-to-influence-of-gd-eob-dtpa-on-proton-density-fat-fraction-using-the-six-echo-dixon-method-in-3-tesla-magnetic-resonance-imaging
#15
Tatsuya Hayashi, Kei Fukuzawa, Hiroshi Kondo, Hiroshi Onodera, Shuji Toyotaka, Rie Tojo, Shimpei Yano, Masakatsu Tano, Tosiaki Miyati, Jun'ichi Kotoku, Takahide Okamoto, Keiko Toyoda, Hiroshi Oba
A diameter of glass bottles in phantoms in the above article (2 cm) was incorrect. The correct diameter is 4.5 cm.
March 14, 2018: Radiological Physics and Technology
https://www.readbyqxmd.com/read/29534862/clinical-implications-of-disappearing-colorectal-liver-metastases-have-changed-in-the-era-of-hepatocyte-specific-mri-and-contrast-enhanced-intraoperative-ultrasonography
#16
Atsushi Oba, Yoshihiro Mise, Hiromichi Ito, Makiko Hiratsuka, Yosuke Inoue, Takeaki Ishizawa, Junichi Arita, Kiyoshi Matsueda, Yu Takahashi, Akio Saiura
BACKGROUND: Clinical implication of disappearing liver metastases (DLMs) from colorectal cancer after chemotherapy needs to be reviewed in the era of modern imaging studies. METHODS: Between 2010 and 2015, 184 patients underwent curative hepatectomy for colorectal liver metastases following preoperative chemotherapy. The sites of metastases detected on pre-chemotherapy CE-CT were examined post-chemotherapy using CE-CT, gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging (EOB-MRI), and contrast-enhanced intraoperative ultrasonography (CE-IOUS)...
March 10, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29532241/gd-eob-dtpa-enhanced-t1-relaxometry-for-assessment-of-liver-function-determined-by-real-time-13-c-methacetin-breath-test
#17
Michael Haimerl, Irene Fuhrmann, Stefanie Poelsterl, Claudia Fellner, Marcel D Nickel, Kilian Weigand, Marc H Dahlke, Niklas Verloh, Christian Stroszczynski, Philipp Wiggermann
OBJECTIVES: To determine whether liver function as determined by intravenous administration of 13 C-methacetin and continuous real-time breath analysis can be estimated quantitatively from gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance (MR) relaxometry. METHODS: Sixty-six patients underwent a 13 C-methacetin breath test (13 C-MBT) for evaluation of liver function and Gd-EOB-DTPA-enhanced T1-relaxometry at 3 T. A transverse 3D VIBE sequence with an inline T1 calculation based on variable flip angles was acquired prior to (T1 pre) and 20 min post-Gd-EOB-DTPA (T1 post) administration...
March 12, 2018: European Radiology
https://www.readbyqxmd.com/read/29528845/preclinical-evaluation-of-severely-defective-manganese-based-nanocrystal-as-a-liver-specific-contrast-media-for-mr-imaging-comparison-with-gd-eob-dtpa-and-mndpdp
#18
Yu Zhang, Xiao-Ping Xiao, Ting Shu, Jing Cai, Xin-Lan Xiao, Yan-Shu Li, Zhong-Wei Zhang, Qun Tang
Manganese-based (chemically formulated of KMnF3 ) nanocrystal was evaluated as a liver-specific contrast agent for MR imaging and its imaging performance was also compared with those of two commercial hepatobiliary contrast media (Gd-EOB-DTPA and MnDPDP). KMnF3 nanocrystal was post-treated using a plasma technique to cause severe defects, leading to appropriate water dispersibility and high relaxivity. Severely defective KMnF3 nanocrystal (SD-KMnF3 ) has characteristic high tolerance, as evidenced by cytotoxicity on the macrophage cell, and acute and subchronic toxicity on the healthy mouse...
June 1, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29501694/effects-on-haematological-and-serum-biochemical-parameters-of-pangasianodon-hypophthalmus-to-an-experimental-infection-of-thaparocleidus-sp-monogenea-dactylogyridae
#19
Saurav Kumar, Ram Prakash Raman, K Pani Prasad, P P Srivastava, Sanath Kumar, K V Rajendran
Monogenea (gill parasite) is a major problem in aquaculture that reduces the growth of cultured fish and adversely affects the economy. The present study was performed to evaluate the impact of various degrees of Thaparocleidus sp. (dactylogyrids, monogenean) infestation on haematological and serum biochemical parameters of Pangasianodon hypophthalmus. A standard cohabitation study, following complete randomized design in triplicate, was conducted to obtain low, moderate and high degrees of infestation in P...
May 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29483451/-radiofrequency-ablation-under-computed-tomography-during-arterial-portography-for-hypovascular-liver-metastases-from-advanced-pancreatic-cancer
#20
Taku Yasumoto, Kenji Uemoto, Koichi Yamada, Hakketsu Koh, Masaru Yamazaki, Norihisa Masai, Daisaku Tatsumi, RyoongJin Oh
A 70's man had been treated with gemcitabine(GEM)and nab-paclitaxel(nabPTX)combination for advanced pancreatic tail cancer with splenic invasion and liver metastases. However, the primary lesion was not controlled, then intensity-modulat- ed radiation therapy(76.5 Gy/17 Fr)was performed for primary lesion. Three grown hypovascular liver metastases were detected by follow-up EOB-MRI and PET-computed tomography(CT)imaging with 18F-FDG. Unfortunately, these lesions were not detected by intravenous injection of contrast media with CT nor ultrasonography...
February 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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