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https://www.readbyqxmd.com/read/28746206/association-between-relative-liver-enhancement-on-gadoxetic-acid-enhanced-magnetic-resonance-images-and-histologic-grade-of-hepatocellular-carcinoma
#1
Young-Joo Jin, Soon Gu Cho, Kun Young Lee, Joon Mee Kim, Jin Woo Lee
We evaluated the association between histologic grade of hepatocellular carcinoma (HCC) and degree of HCC enhancement on Gd-EOB-DTPA (Gadoxetic acid, Primovist)-enhanced magnetic resonance images (MRI) in HCC patients.A total of 121 patients who underwent curative surgical resection for HCC at our institution between January 2012 and March 2015 were retrospectively analyzed. Gadoxetic acid enhanced MRI was performed in all patients before surgery. Signal intensities of HCC and peri-HCC areas were measured using regions of interest...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28734194/high-yield-one-pot-production-of-18-f-fch-via-a-modified-tracerlab-fxfn-module
#2
Ya-Yao Huang, Chia-Ling Tsai, Hsiang-Ping Wen, Kai-Yuan Tzen, Ruoh-Fen Yen, Chyng-Yann Shiue
INTRODUCTION: [(18)F]Fluoromethylcholine ([(18)F]FCH) is a potent tumors imaging agent. In order to fulfill the demand of pre-clinical and clinical studies, we have developed an automated high yield one-pot synthesis of this potent tumors imaging agent. METHODS: [(18)F]FCH was synthesized using a modified TRACERlab FxFN module. Briefly, dibromomethane (10% in CH3CN) was fluorinated with K[(18)F]/K 2.2.2 in a glassy carbon reaction vessel at 120°C for about 5min to generate [(18)F]fluorobromomethane ([(18)F]FBM)...
July 15, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28731820/uncommon-neoplasms-of-the-biliary-tract-radiological-findings
#3
Vincenza Granata, Roberta Fusco, Orlando Catalano, Salvatore Filice, Antonio Avallone, Mauro Piccirillo, Maddalena Leongito, Raffaele Palaia, Roberto Grassi, Francesco Izzo, Antonella Petrillo
OBJECTIVES: To report our cancer center experience in the biliary tumors incidence other than cholangiocellular-carcinoma (CCC), emphasizing the radiological features. METHODS: 197 patients with biliary disease undergoing Gd-EOB-DTPA-enhanced MRI were reviewed. Four radiologists evaluated retrospectively size, structure, anatomical site, and signal intensity of lesions on MRI. Enhancement-pattern during the arterial-, portal-, and late-phase on US, CT and MR study was assessed as well as the enhancement pattern during the hepatobiliary-phase on MRI...
July 21, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28726119/a-cost-effectiveness-analysis-of-the-diagnostic-strategies-for-differentiating-focal-nodular-hyperplasia-from-hepatocellular-adenoma
#4
Chong Hyun Suh, Kyung Won Kim, Seong Ho Park, Sangjin Shin, Jeonghoon Ahn, Junhee Pyo, Atul B Shinagare, Katherine M Krajewski, Nikhil H Ramaiya
OBJECTIVES: We evaluated the cost-effectiveness of a gadoxetic acid-enhanced MRI (EOB-MRI) strategy compared with conventional MRI strategy and biopsy to differentiate focal nodular hyperplasia (FNH) from hepatocellular adenoma (HCA). METHODS: A decision tree model was constructed to compare the cost-effectiveness of EOB-MRI, conventional MRI with extracellular contrast agents, and biopsy as the initial diagnostic modality in patients with incidentally detected focal liver lesions suspected of being FNH or HCA...
July 19, 2017: European Radiology
https://www.readbyqxmd.com/read/28723741/characterization-of-small-%C3%A2-3%C3%A2-cm-hepatic-lesions-with-atypical-enhancement-feature-and-hypointensity-in-hepatobiliary-phase-of-gadoxetic-acid-enhanced-mri-in-cirrhosis-a-stard-compliant-article
#5
Seung Kak Shin, Yun Soo Kim, Seung Joon Choi, Young Sup Shim, Dong Hae Jung, Oh Sang Kwon, Duck Joo Choi, Ju Hyun Kim
It is difficult to characterize the nodular lesions in cirrhotic liver if typical enhancement pattern is not present on dynamic contrast-enhanced imagings. Although the signal intensity of the hepatobiliary phase in gadoxetic acid-enhanced magnetic resonance imaging (MRI) is helpful for characterization of the lesions, some dysplastic nodules may also exhibit low signal intensity in the hepatobiliary phase. We aimed to assess the usefulness of gadoxetic acid (Gd-EOB-DTPA)-enhanced MRI including diffusion-weighted imaging (DWI) for differentiation between atypical small hepatocellular carcinomas (HCCs) and dysplastic nodules showing low signal intensity (SI) in the hepatobiliary phase, and to evaluate the MRI findings in determining the histological grade of atypical HCCs in patients with cirrhosis...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28699910/quantitative-evaluation-of-gd-eob-dtpa-uptake-in-focal-liver-lesions-by-using-t1-mapping-differences-between-hepatocellular-carcinoma-hepatic-focal-nodular-hyperplasia-and-cavernous-hemangioma
#6
Zhenpeng Peng, Chang Li, Tao Chan, Huasong Cai, Yanji Luo, Zhi Dong, Zi-Ping Li, Shi-Ting Feng
OBJECTIVES: To investigate the difference of T1 relaxation time on Gd-EOB-DTPA-enhanced MRI in hepatocellular carcinoma (HCC), hepatic focal nodular hyperplasia (FNH) and cavernous hemangioma of liver (CHL), and to quantitatively evaluate the uptake of Gd-EOB-DTPA in these three focal liver lesions (FLLs). RESULTS: The T1P of CHL was significantly higher than those of HCC and FNH (P < 0.05). Reduction of T1 relaxation time on hepatobiliary phase could be observed in all three types of lesions...
July 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28693975/reply-to-the-letter-to-the-editor-regarding-the-diagnostic-advantage-of-eob-mr-imaging-over-ct-in-the-detection-of-liver-metastasis-in-patients-with-potentially-resectable-pancreatic-cancer-methodological-issues
#7
EDITORIAL
Takaaki Ito, Toru Imai, Katsuhiro Omae, Teiichi Sugiura, Katsuhiko Uesaka
No abstract text is available yet for this article.
July 4, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28689744/the-diagnostic-advantage-of-eob-mr-imaging-over-ct-in-the-detection-of-liver-metastasis-in-patients-with-potentially-resectable-pancreatic-cancer-methodological-issues
#8
EDITORIAL
Saeid Safiri, Erfan Ayubi
No abstract text is available yet for this article.
July 1, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28673445/does-injection-flow-rate-have-an-impact-on-arterial-phase-image-degradation-in-liver-mri-a-comparison-of-gadoxetic-acid-versus-gadobutrol
#9
V Cohen-Hallaleh, L Guo, H Hosseini-Nik, N Razaghi Kashani, R Menezes, K Jhaveri
AIM: To evaluate retrospectively the impact of injection flow rate on arterial phase image degradation in liver magnetic resonance imaging (MRI) with gadoxetic acid (Gd-EOB-DTPA) compared to gadobutrol. MATERIALS AND METHODS: Two hundred consecutive patients who had undergone liver MRI were enrolled in this Health Insurance Portability and Accountability Act (HIPAA)-compliant institutional review board (IRB)-approved study and were divided into three groups. Group 1 (50 patients) and 2 (50 patients) had undergone MRI performed with gadoxetic acid (fixed 10 ml) at flow rate of 1 and 2 ml/s, respectively...
June 30, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28651300/noninvasive-assessment-of-advanced-fibrosis-based-on-hepatic-volume-in-patients-with-nonalcoholic-fatty-liver-disease
#10
Tatsuya Hayashi, Satoshi Saitoh, Kei Fukuzawa, Yoshinori Tsuji, Junji Takahashi, Yusuke Kawamura, Norio Akuta, Masahiro Kobayashi, Kenji Ikeda, Takeshi Fujii, Tosiaki Miyati, Hiromitsu Kumada
Background/Aims: Noninvasive liver fibrosis evaluation was performed in patients with nonalcoholic fatty liver disease (NAFLD). We used a quantitative method based on the hepatic volume acquired from gadoxetate disodium-enhanced (Gd-EOB-DTPA-enhanced) magnetic resonance imaging (MRI) for diagnosing advanced fibrosis in patients with NAFLD. Methods: A total of 130 patients who were diagnosed with NAFLD and underwent Gd-EOB-DTPA-enhanced MRI were retrospectively included...
June 27, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28624009/measuring-hepatic-functional-reserve-using-t1-mapping-of-gd-eob-dtpa-enhanced-3t-mr-imaging-a-preliminary-study-comparing-with-99m-tc-gsa-scintigraphy-and-signal-intensity-based-parameters
#11
Masataka Nakagawa, Tomohiro Namimoto, Kie Shimizu, Kosuke Morita, Fumi Sakamoto, Seitaro Oda, Takeshi Nakaura, Daisuke Utsunomiya, Shinya Shiraishi, Yasuyuki Yamashita
PURPOSE: To determine the utility of liver T1-mapping on gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA) enhanced magnetic resonance (MR) imaging for the measurement of liver functional reserve compared with the signal intensity (SI) based parameters, technetium-99m-galactosyl serum albumin ((99m)Tc-GSA) scintigraphy and indocyanine green (ICG) clearance. MATERIALS AND METHODS: This retrospective study included 111 patients (Child-Pugh-A 90; -B 21) performed with both Gd-EOB-DTPA enhanced liver MR imaging and (99m)Tc-GSA (76 patients with ICG)...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28619538/synthesis-and-biological-evaluation-of-2-3-4-dimethoxyphenyl-6-2-18-f-fluoroethoxy-benzothiazole-18-f-fedbt-for-pet-imaging-of-breast-cancer
#12
Geng-Ying Li, Daria D Vaulina, Jia-Je Li, Olga S Fedorova, Hsin-Ell Wang, Ren-Shyan Liu, Raisa N Krasikova, Chuan-Lin Chen
Given the ever-present demand for improved PET radiotracer in oncology imaging, we have synthesized 2-(3,4-dimethoxyphenyl)-6-(2-[(18)F]fluoroethoxy)benzothiazole ([(18)F]FEDBT), a fluorine-18-containing fluoroethylated benzothiazole to explore its utility as a PET imaging tracer. [(18)F]FEDBT was prepared via kryptofix-mediated nucleophilic substitution of the tosyl group precursor. Fractionated ethanol-based solid-phase (SPE cartridge-based) purification afforded [(18)F]FEDBT in 60% radiochemical yield (EOB), with radiochemical purity in excess of 98% and the specific activity was 35GBq/μmol...
August 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28607606/diagnostic-value-of-gd-eob-dtpa-mri-for-hepatocellular-adenoma-a-meta-analysis
#13
Yongfei Guo, Wenjuan Li, Zhinan Xie, Yi Zhang, Yijie Fang, Wenli Cai, Guobin Hong
Objective: This study aimed to systematically review the gadoxetic acid-enhanced magnetic resonance imaging (Gd-EOB-DTPA-MRI) findings of hepatocellular adenoma (HCA), especially focusing on the diagnostic value of low signal intensity (SI) in the hepatocyte-phase (HBP) for differentiating HCA from focal nodular hyperplasia (FNH). Methods: A thorough literature search was conducted in PubMed, Excerpta Medica Database (EMBASE) and China National Knowledge Infrastructure databases (CNKI) to identify studies evaluating Gd-EOB-DTPA-MRI presentations of HCA...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28554730/synthesis-and-preliminary-biological-evaluation-of-radiolabeled-5-bdbd-analogs-as-new-candidate-pet-radioligands-for-p2x4-receptor
#14
Min Wang, Mingzhang Gao, Jill A Meyer, Jonathan S Peters, Hamideh Zarrinmayeh, Paul R Territo, Gary D Hutchins, Qi-Huang Zheng
P2X4 receptor has become an interesting molecular target for treatment and PET imaging of neuroinflammation and associated brain diseases such as Alzheimer's disease. This study reports the first design, synthesis, radiolabeling and biological evaluation of new candidate PET P2X4 receptor radioligands using 5-BDBD, a specific P2X4 receptor antagonist, as a scaffold. 5-(3-Hydroxyphenyl)-1-[(11)C]methyl-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one (N-[(11)C]Me-5-BDBD analog, [(11)C]9) and 5-(3-Bromophenyl)-1-[(11)C]methyl-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one (N-[(11)C]Me-5-BDBD, [(11)C]8c) were prepared from their corresponding desmethylated precursors with [(11)C]CH3OTf through N-[(11)C]methylation and isolated by HPLC combined with SPE in 30-50% decay corrected radiochemical yields with 370-1110GBq/µmol specific activity at EOB...
May 18, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28547117/non-hypervascular-hypointense-nodules-at-gadoxetic-acid-mri-hepatocellular-carcinoma-risk-assessment-with-emphasis-on-the-role-of-diffusion-weighted-imaging
#15
Chiara Briani, Marco Di Pietropaolo, Massimo Marignani, Francesco Carbonetti, Paola Begini, Vincenzo David, Elsa Iannicelli
INTRODUCTION AND AIM: In cirrhotic patients, the characterization of hypovascular nodules, hypointense on hepatobiliary phase gadoxetic acid disodium-enhanced magnetic resonance images (Gd-EOB-DTPA-enhanced MRI), is essential to look for the proper approach strategy. Our objective was to evaluate the imaging features and risk assessment of hypovascular nodules, hypointense on Gd-EOB-DTPA-enhanced MRI, focusing on the diagnostic value of diffusion-weighted imaging (DWI). MATERIAL AND METHODS: This prospective study includes 35 patients with 50 hypovascular hypointense nodules...
May 25, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28530407/gadolinium-complex-of-1-4-7-10-tetraazacyclododecane-1-4-7-trisacetic-acid-do3a-ethoxybenzyl-eob-conjugate-as-a-new-macrocyclic-hepatobiliary-mri-contrast-agent
#16
Ah Rum Baek, Hee-Kyung Kim, Subin Park, Gang Ho Lee, Hyo Jeung Kang, Jae-Chang Jung, Joon-Suk Park, Hun-Kyu Ryeom, Tae-Jeong Kim, Yongmin Chang
We report the synthesis of a macrocyclic Gd chelate based on a 1,4,7,10-tetraazacyclododecane-1,4,7-trisacetic acid (DO3A) coordinationn cage bearing an ethoxybenzyl (EOB) moiety and discuss its use as a T1 hepatobiliary magnetic resonance imaging (MRI) contrast agent. The new macrocyclic liver agent shows high chelation stability and high r1 relaxivity compared with linear-type Gd chelates, which are the current clinically approved liver agents. Our macrocyclic, liver-specific Gd chelate was evaluated in vivo through biodistribution analysis and liver MRI, which demonstrated its high tumor detection sensitivity and suggested that the new Gd complex is a promising contrast agent for liver cancer imaging...
May 31, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28529683/gd-eob-dtpa-based-magnetic-resonance-imaging-for-predicting-liver-response-to-portal-vein-embolization
#17
Janio Szklaruk, Gustavo Luersen, Jingfei Ma, Wei Wei, Michelle Underwood
AIM: To evaluate the correlation between degree of kinetic growth (kGR) of the liver following portal vein embolization (PVE) liver and the enhancement of the during the hepatobiliary phase of contrast administration and to evaluate if the enhancement can be used to predict response to PVE prior to the procedure. METHODS: Seventeen patients were consented for the prospective study. All patients had an MR of the abdomen with Gd-EOB-DTPA. Fourteen patients underwent PVE...
April 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/28476245/twist-vibe-five-arterial-phase-technology-decreases-transient-severe-motion-after-bolus-injection-of-gd-eob-dtpa
#18
H Li, Y Xiao, S Wang, Y Li, X Zhong, W Situ, E Xiao, Z Zhang
AIM: To investigate whether time-resolved imaging with interleaved stochastic trajectories (TWIST)-volumetric interpolated breath-hold examination (VIBE) hepatic arterial phase imaging technique improves image quality in patients experiencing transient severe motion (TSM) during abdominal magnetic resonance imaging (MRI) with gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA). MATERIALS AND METHODS: This retrospective study compares TSM in MRI images from 28 patients with focal liver lesions imaged with gadopentetic acid (Gd-DTPA) and 28 patients with focal liver lesions imaged with Gd-EOB-DTPA...
May 2, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28474177/evaluation-of-biliary-ductal-anatomy-in-potential-living-liver-donors-comparison-between-mrcp-and-gd-eob-dtpa-enhanced-mri
#19
D Santosh, A Goel, I W Birchall, A Kumar, K H Lee, V H Patel, G Low
PURPOSE: To compare magnetic resonance cholangiopancreatography (MRCP) and Gd-EOB-DTPA-enhanced MRI in the evaluation of the biliary anatomy in potential living liver donors (LLDs). METHODS: A retrospective study was conducted in a tertiary care liver transplant center after obtaining ethics and institutional approvals. A total of 42 potential LLD MRI examinations were performed between November 2013 and March 2016. All patients underwent a standard MRI protocol which included MRCP and Gd-EOB-DTPA-enhanced MRI sequences in a single session...
May 4, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28472767/critical-analysis-of-the-major-and-ancillary-imaging-features-of-li-rads-on-127-proven-hccs-evaluated-with-functional-and-morphological-mri-lights-and-shadows
#20
Vincenza Granata, Roberta Fusco, Antonio Avallone, Francesco Filice, Fabiana Tatangelo, Mauro Piccirillo, Roberto Grassi, Francesco Izzo, Antonella Petrillo
PURPOSE: To report a critical analysis of major and ancillary MR imaging features in assessment of HCC. METHODS: Retrospectively we evaluated 70 cirrhotic patients with 173 nodules, which were subjected to MR study at 0 time (MR0), after 3 (MR3) and 6 months (MR6) using two different contrast media. EOB-GD-DTPA was injected at MR0 and MR6, while Gd-BT-DO3A at MR3. Three expert hepatic radiologists reviewed all images, recording, according to LI-RADS, the size, the presence and quality of arterial-phase hyperenhancement, washout and capsule appearance, threshold growth...
April 19, 2017: Oncotarget
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