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https://www.readbyqxmd.com/read/28195848/influence-of-indocyanine-green-on-hepatic-gd-eob-dtpa-uptake-a-proof-of-concept-study-in-mice
#1
Hiroyuki Akai, Koichiro Yasaka, Masanori Nojima, Yusuke Inoue, Kuni Ohtomo, Shigeru Kiryu
OBJECTIVES: The aim of this study was to explore the influence of indocyanine green (ICG) on hepatic uptake of gadolinium ethoxybenzyldiethylenetriaminepenta-acetic acid (Gd-EOB-DTPA). MATERIALS AND METHODS: Groups of 6 female C57BL6 mice were injected with 5 mg/kg ICG, 20 mg/kg ICG, or phosphate-buffered saline (control group) 10 minutes before the injection of Gd-EOB-DTPA; identical 3-dimensional gradient echo T1-weighted images were subsequently obtained to create time-intensity curves and to measure the peak contrast ratios (CRs) of liver parenchyma...
February 10, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28181823/diagnostic-value-of-gd-eob-dtpa-enhanced-mr-cholangiography-in-non-invasive-detection-of-postoperative-bile-leakage
#2
Melahat M Kul, Ayşe A Erden, Ebru E Düşünceli Atman
OBJECTIVE: To assess the diagnostic value of dynamic T1-weighted (T1w) gadolinium ethoxybenzyl diethylentriamine penta-acetic acid (Gd-EOB-DTPA)-enhanced MR Cholangiography (MRC) for the detection of active bile leaks. METHODS: A total of 28 patients with suspected biliary leakage who underwent routine T2w-MRC and T1w-GD-EOB-DTPA-enhanced MRC at our institution from February 2013 to June 2016 were included in this study. The image sets were retrospectively analysed in consensus by 3 radiologists...
February 9, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28166142/detection-and-viability-of-colorectal-liver-metastases-after-neoadjuvant-chemotherapy-a-multiparametric-pet-ct-mri-study
#3
Vincent Dunet, Nermin Halkic, John O Prior, Anass Anaye, Reto A Meuli, Christine Sempoux, Alban Denys, Sabine Schmidt
PURPOSE: The aim of this study was to compare combined gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA)-enhanced and diffusion-weighted (DW) MRI with IV contrast-enhanced F-FDG PET/CT to detect and assess the viability of colorectal liver metastases (CLMs) after neoadjuvant chemotherapy (NAC). PATIENTS AND METHODS: After NAC, 45 patients with CLMs were prospectively enrolled and underwent combined Gd-EOB-DTPA-enhanced and DW-MRI and contrast-enhanced F-FDG PET/CT...
February 3, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28133128/-a-case-of-surgical-resection-for-liver-metastasis-of-gastric-cancer-treated-with-neoadjuvant-chemotherapy
#4
Soichiro Mori, Masahiro Tanemura, Kentaro Kishi, Mitsuyoshi Tei, Toru Masuzawa, Yozo Suzuki, Masahisa Otsuka, Kenta Furukawa, Yoshihiro Sakano, Kazunori Mori, Hiroki Akamatsu
The patient was a 73-year-old man. Upper gastrointestinal endoscopy revealed a type 3 tumor in the antrum of the stomach. Preoperative CT imaging showed multiple liver metastases(S2, S3, S4, S6, S7). We administered 2 courses of chemotherapy( XP therapy)for the unresectable gastric cancer; the impact of the neoadjuvant therapy was PR. We performed distal gastrectomy and D2 dissection. After gastric resection, we administered an additional 3 courses of XP therapy. Unfortunately, new lesions of liver metastases were recurrent at S5 and S8...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28131663/pulmonary-hypertension-and-ventilation-during-exercise-role-of-the-pre-capillary-component
#5
Sergio Caravita, Andrea Faini, Gael Deboeck, Antoine Bondue, Robert Naeije, Gianfranco Parati, Jean-Luc Vachiéry
BACKGROUND: Excessive exercise-induced hyperventilation and high prevalence of exercise oscillatory breathing (EOB) are present in patients with post-capillary pulmonary hypertension (PH) complicating left heart disease (LHD). Patients with pre-capillary PH have even higher hyperventilation but no EOB. We sought to determine the impact of a pre-capillary component of PH on ventilatory response to exercise in patients with PH and left heart disease. METHODS: We retrospectively compared patients with idiopathic or heritable pulmonary arterial hypertension (PAH, n = 29), isolated post-capillary PH (IpcPH, n = 29), and combined post- and pre-capillary PH (CpcPH, n = 12)...
December 23, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28128291/gd-eob-dtpa-enhanced-mr-relaxometry-for-the-detection-and-staging-of-liver-fibrosis
#6
Michael Haimerl, Kirsten Utpatel, Niklas Verloh, Florian Zeman, Claudia Fellner, Dominik Nickel, Andreas Teufel, Stefan Fichtner-Feigl, Matthias Evert, Christian Stroszczynski, Philipp Wiggermann
Gd-EOB-DTPA, a liver-specific contrast agent with T1-shortening effects, is routinely used in clinical routine for detection and characterization of focal liver lesions and has recently received increasing attention as a tool for the quantitative analyses of liver function. We report the relationship between the extent of Gd-EOB-DTPA- induced T1 relaxation and the degree of liver fibrosis, which was assessed according to the METAVIR score. For the T1 relaxometry, a transverse 3D VIBE sequence with inline T1 calculation was acquired prior to and 20 minutes after Gd-EOB-DTPA administration...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28119025/synthesis-of-carbon-11-labeled-isonicotinamides-as-new-potential-pet-agents-for-imaging-of-gsk-3-enzyme-in-alzheimer-s-disease
#7
Mingzhang Gao, Min Wang, Qi-Huang Zheng
The authentic standards 2-(cyclopropanecarboxamido)-N-(4-methoxypyridin-3-yl)isonicotinamide (4a) and 2-(cyclopropanecarboxamido)-N-(4-(4-methoxyphenyl)pyridin-3-yl)isonicotinamide (7a), and their corresponding precursors 2-(cyclopropanecarboxamido)-N-(4-hydroxypyridin-3-yl)isonicotinamide (4b) and 2-(cyclopropanecarboxamido)-N-(4-(4-hydroxyphenyl)pyridin-3-yl)isonicotinamide (7b) were synthesized from methyl 2-aminoisonicotinate and cyclopropanecarbonyl chloride with overall chemical yield 47% in three steps, 22% in four steps, 40% in three steps, and 17% in four steps, respectively...
January 16, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28090793/development-and-validation-of-a-predictor-of-insufficient-enhancement-during-the-hepatobiliary-phase-of-gd-eob-dtpa-enhanced-magnetic-resonance-imaging
#8
Enming Cui, Wansheng Long, Liangping Luo, Maoqing Hu, Liebin Huang, Xiangmeng Chen
Background Insufficient enhancement of liver parenchyma negatively affects diagnostic accuracy of Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI). Currently, there is no reliable method for predicting insufficient enhancement during the hepatobiliary phase (HBP) in Gd-EOB-DTPA-enhanced MRI. Purpose To develop a predictor for insufficient enhancement of liver parenchyma during HBP in Gd-EOB-DTPA-enhanced MRI. Material and Methods In order to formulate a HBP enhancement test (HBP-ET), clinical factors associated with relative enhancement ratio (RER) of liver parenchyma were retrospectively determined from the datasets of 156 patients (Development group) who underwent Gd-EOB-DTPA-enhanced MRI between November 2012 and May 2015...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28070844/gd-eob-dtpa-enhanced-mri-t1-mapping-for-assessment-of-liver-function-in-rabbit-fibrosis-model-comparison-of-hepatobiliary-phase-images-obtained-at-10-and-20%C3%A2-min
#9
Zhi-Peng Zhou, Li-Ling Long, Li-Juan Huang, Teng-Fei Yang, Zhong-Kui Huang
OBJECTIVES: To compare hepatobiliary phase (HBP) images obtained at 10 and 20 min after Gd-EOB-DTPA-enhanced MRI for assessment of liver function in rabbit fibrosis model on 3.0 T MR imaging. METHODS: 34 animals were separated into three groups: 5 for a control group, 14 for a mild fibrosis group, and 15 for a severe fibrosis group based on pathological proof. T1 relaxation times (T1rt) were measured on T1 mapping and reduction rates of T1rt (rrT1rt) were calculated...
January 9, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28062263/the-natural-history-of-streptozotocin-stimulated-non-alcoholic-steatohepatitis-mice-followed-by-gd-eob-dtpa-enhanced-mri-comparison-with-simple-steatosis-mice
#10
Hiroyuki Akai, Shigeru Kiryu, Yasunori Ohta, Koichiro Yasaka, Yoshiyasu Nakano, Yusuke Inoue, Kuni Ohtomo
PURPOSE: To clarify the development of HCC, temporal change of steatosis and Gd-EOB-DTPA enhancement of non-alcoholic steatohepatitis (NASH) model mice by magnetic resonance imaging (MRI). MATERIALS AND METHODS: All animal experiments were approved by the institution's Animal Research Committee. MRI was performed on six NASH and six simple steatosis (SS) model mice every 2weeks from the ages of 8weeks to 16weeks. The sequential changes in the number and size of the focal liver lesions detected on Gd-EOB-DTPA-enhanced MRI were evaluated...
January 3, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28048247/we-fg-202-10-assessing-hepatocellular-carcinoma-hcc-response-to-sbrt-using-dce-mri
#11
Y Yuan, M Buckstein, M Chao, K Rosenzweig, Y Lo
PURPOSE: To investigate the feasibility of using DCE-MRI to assess treatment response of HCC to SBRT. METHODS: For seven liver HCC patients treated by photon SBRT with radiation dose ranging from 35 to 50 Gy in 5 fractions, T1-weighted DCE-MRI was performed before and at 1-3 months after the treatment. Each study included one pre-contrast and five post Gd-EOB-DTPA-enhanced imaging series. The target tumor and the liver were manually outlined on the arterial phase images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27993534/assessment-of-the-link-between-quantitative-biexponential-diffusion-weighted-imaging-and-contrast-enhanced-mri-in-the-liver
#12
Hildebrand Dijkstra, Matthijs Oudkerk, Peter Kappert, Paul E Sijens
PURPOSE: To investigate if intravoxel incoherent motion (IVIM) modeled diffusion-weighted imaging (DWI) can be linked to contrast-enhanced (CE-)MRI in liver parenchyma and liver lesions. METHODS: Twenty-five patients underwent IVIM-DWI followed by multiphase CE-MRI using Gd-EOB-DTPA (n=20) or Gd-DOTA (n=5) concluded with IVIM-DWI. Diffusion (Dslow), microperfusion (Dfast), its fraction (ffast), wash-in-rate (Rearly) and late-enhancement-rate (Rlate) of Gd-EOB-DTPA were calculated voxel-wise for the liver...
December 18, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27986173/liver-function-assessment-by-magnetic-resonance-imaging
#13
Emre Ünal, Deniz Akata, Musturay Karcaaltincaba
Liver function assessment by hepatocyte-specific contrast-enhanced magnetic resonance imaging is becoming a new biomarker. Liver function can be assessed by T1 mapping (reduction rate) and signal intensity measurement (relative enhancement ratio) before and after GD-EOB-DTPA (gadoxetic acid) administration, as alternative to Tc-99m galactosyl serum albumin scintigraphy, 99m Tc-labeled mebrofenin scintigraphy, and indocyanine green clearance test. Magnetic resonance imaging assessment of liver function can enable diagnosis of cirrhosis, nonalcoholic fatty liver disease associated fibrosis and steatohepatitis, primary sclerosing cholangitis, toxic hepatitis, and chemotherapy and radiotherapy-related changes, which may be only visible on hepatobiliary phase images...
December 2016: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/27986172/magnetic-resonance-imaging-of-liver-metastasis
#14
Ali Devrim Karaosmanoglu, Mehmet Ruhi Onur, Mustafa Nasuh Ozmen, Deniz Akata, Musturay Karcaaltincaba
Liver magnetic resonance imaging (MRI) is becoming the gold standard in liver metastasis detection and treatment response assessment. The most sensitive magnetic resonance sequences are diffusion-weighted images and hepatobiliary phase images after Gd-EOB-DTPA. Peripheral ring enhancement, diffusion restriction, and hypointensity on hepatobiliary phase images are hallmarks of liver metastases. In patients with normal ultrasonography, computed tomography (CT), and positron emission tomography (PET)-CT findings and high clinical suspicion of metastasis, MRI should be performed for diagnosis of unseen metastasis...
December 2016: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/27986169/hepatic-steatosis-etiology-patterns-and-quantification
#15
Ilkay S Idilman, Ilknur Ozdeniz, Musturay Karcaaltincaba
Hepatic steatosis can occur because of nonalcoholic fatty liver disease (NAFLD), alcoholism, chemotherapy, and metabolic, toxic, and infectious causes. Pediatric hepatic steatosis is also becoming more frequent and can have distinctive features. The most common pattern is diffuse form; however, it can present in heterogenous, focal, multinodular, perilesional, perivascular, subcapsular, and lobar forms. Focal steatosis and fat sparing can occur because of the presence of veins of Sappey, pancreaticoduodenal vein, and aberrant right and left gastric veins, which drain into the liver as third inflow...
December 2016: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/27966044/gd-eob-dtpa-enhanced-mri-for-monitoring-future-liver-remnant-function-after-portal-vein-embolization-and-extended-hemihepatectomy-a-prospective-trial
#16
Dominik Geisel, Philip Raabe, Lutz Lüdemann, Maciej Malinowski, Martin Stockmann, Daniel Seehofer, Johann Pratschke, Bernd Hamm, Timm Denecke
OBJECTIVES: To evaluate changes in liver function after right portal vein embolization (PVE) and extended right hemihepatectomy using gadolinium ethoxybenzyl-DTPA-enhanced (Gd-EOB-DTPA) MRI. METHODS: In this prospective trial, 37 patients undergoing PVE were examined before and 14 and 28 days after PVE and 10 days after extended hemihepatectomy using Gd-EOB-DTPA-enhanced MRI. Lobar volume, kinetic growth rate (KGR), relative enhancement (RE) as well as hepatocellular uptake index (HUI) and fat signal fraction (FSF) were calculated for each lobe...
December 13, 2016: European Radiology
https://www.readbyqxmd.com/read/27951418/comparison-of-the-dwi-and-gd-eob-dtpa-enhanced-mri-on-assessing-the-hepatic-ischemia-and-reperfusion-injury-after-partial-hepatectomy
#17
COMPARATIVE STUDY
Yu Lu, Pengfei Liu, Peng Fu, Yaodong Chen, Dong Nan, Xiuhua Yang
OBJECTIVE: To compare two different imaging media, diffusion weighted imaging (DWI) with apparent diffusion coefficient (ADC) and Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) with perfusion parameters K(trans), K(ep), and relative contrast enhancement index (RCEI), in assessing the liver function via ischemia/perfusion injury (IRI) + partial hepatectomy rat model. METHODS: Rats underwent 0, 30 and 60min of ischemia/reperfusion with 30% of hepatectomy before subjected to Gd-EOB-DTPA-enhanced MRI in addition to (99m)Tc-GSA scintigraphy...
February 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27943555/spio-enhanced-mri-is-useful-in-predicting-malignant-potential-of-vascular-transformation-of-hypointense-hypovascular-nodules-on-gd-eob-dtpa-enhanced-mri
#18
Yoshiaki Tanaka, Takahide Nakazawa, Tomoyoshi Inoue, Keiko Yamane, Kousuke Kubota, Haruki Uojima, Juichi Takada, Yusuke Okuwaki, Hisashi Hidaka, Akitaka Shibuya, Shigehiro Kokubu, Keiji Matsunaga, Wasaburo Koizumi
AIM: To examine whether superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance imaging (MRI) can be used to assess the malignant potential of hepatic hypovascular nodules showing hypointensity during the hepatobiliary phase (HBP) on gadoxetic acid (Gd-EOB-DTPA)-enhanced MRI. METHODS: The study included 42 patients with chronic liver disease who had small hypovascular nodules (5-15 mm) showing hypointensity during the HBP on Gd-EOB-DTPA-enhanced MRI. SPIO-enhanced T2-weighted MRI analyzed whether the signal intensity of each nodule was high...
December 11, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/27937040/multiparametric-or-practical-quantitative-liver-mri-towards-millisecond-fat-fraction-kilopascal-and-function-era
#19
Emre Unal, Ilkay Sedakat Idilman, Muşturay Karçaaltıncaba
New advances in liver magnetic resonance imaging (MRI) may enable diagnosis of unseen pathologies by conventional techniques. Normal T1 (550-620 ms for 1.5 T and 700-850 ms for 3 T), T2, T2* (>20 ms), T1rho (40-50 ms) mapping, proton density fat fraction (PDFF) (≤5%) and stiffness (2-3kPa) values can enable differentiation of a normal liver from chronic liver and diffuse diseases. Gd-EOB-DTPA can enable assessment of liver function by using postcontrast hepatobiliary phase or T1 reduction rate (normally above 60%)...
February 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27936106/feasibility-of-10-minute-delayed-hepatocyte-phase-imaging-using-a-30%C3%A2-flip-angle-in-gd-eob-dtpa-enhanced-liver-mri-for-the-detection-of-hepatocellular-carcinoma-in-patients-with-chronic-hepatitis-or-cirrhosis
#20
Inhwan Jeon, Eun-Suk Cho, Joo Hee Kim, Dae Jung Kim, Jeong-Sik Yu, Jae-Joon Chung
OBJECTIVES: To compare 10-minute (min) delayed hepatocyte phase imaging (HPI) using a 30° flip angle (FA) (10m-FA30) and 20-min delayed HPI using a 10° FA (20m-FA10) or 30° FA (20m-FA30) in Gd-EOB-DTPA-enhanced MRI in patients with chronic hepatitis or cirrhosis, in terms of lesion-to-liver contrast-to-noise ratio (CNR) for hepatocellular carcinoma (HCC) and detection sensitivity for focal hepatic lesions (FHLs). MATERIALS AND METHODS: One hundred and four patients with 168 HCCs and 55 benign FHLs who underwent Gd-EOB-DTPA-enhanced MRI with 10m-FA30, 20m-FA10, and 20m-FA30 were enrolled...
2016: PloS One
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