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https://www.readbyqxmd.com/read/27907063/evaluation-of-focal-liver-reaction-after-proton-beam-therapy-for-hepatocellular-carcinoma-examined-using-gd-eob-dtpa-enhanced-hepatic-magnetic-resonance-imaging
#1
Shigeyuki Takamatsu, Kazutaka Yamamoto, Yoshikazu Maeda, Mariko Kawamura, Satoshi Shibata, Yoshitaka Sato, Kazuki Terashima, Yasuhiro Shimizu, Yuji Tameshige, Makoto Sasaki, Satoko Asahi, Tamaki Kondou, Satoshi Kobayashi, Osamu Matsui, Toshifumi Gabata
BACKGROUND: Proton beam therapy (PBT) achieves good local control for hepatocellular carcinoma (HCC), and toxicity tends to be lower than for photon radiotherapy. Focal liver parenchymal damage in radiotherapy is described as the focal liver reaction (FLR); the threshold doses (TDs) for FLR in the background liver have been analyzed in stereotactic ablative body radiotherapy and brachytherapy. To develop a safer approach for PBT, both TD and liver volume changes are considered clinically important in predicting the extent of damage before treatment, and subsequently in reducing background liver damage...
2016: PloS One
https://www.readbyqxmd.com/read/27872350/simultaneous-acquisition-of-high-contrast-and-quantitative-liver-t1-images-using-3d-phase-sensitive-inversion-recovery-a-feasibility-study
#2
Yasuhiro Fujiwara, Hirotoshi Maruyama, Nobuyuki Kosaka, Yoshiyuki Ishimori
BACKGROUND: Tumor-to-liver contrast is low in images of chronically diseased livers because gadolinium-based hepatocyte-specific contrast agents (Gd-EOB-DTPA) accumulate less to hepatocytes. PURPOSE: To determine whether phase-sensitive inversion recovery (PSIR) could improve the T1 contrasts of Gd-based contrast agents and liver parenchyma and simultaneously provide accurate T1 values for abdominal organs. MATERIAL AND METHODS: The image contrasts of phantoms with different Gd concentrations that were obtained using PSIR were compared to conventional turbo field echo (TFE) results...
November 21, 2016: Acta Radiologica
https://www.readbyqxmd.com/read/27867178/mtf-measurement-of-mr-blurring-in-liver-dynamic-mri-with-gd-eob-dtpa
#3
Masashi Kikuchi, Norio Hayashi, Kazuma Yarita, Kozue Sakata, Koichi Ujita, Satoshi Matsuda, Yuichi Teduka
During the arterial phase acquisition of Gd-EOB-DTPA examinations, use of a small volume of the Gd-EOB-DTPA may make it difficult the encoding center of the k-space, and produce blurring. The previous studies revealed the encoding technique of the k-space was one of the most important reasons. However, there is no report to discuss the reasons with quantitative evaluations. The purpose of this study was to quantitatively evaluate the characteristics of the artifacts using different k-space encoding techniques (centric-view ordering (CVO) and sequential-view ordering (SVO)) for liver dynamic MRI in computer simulation study...
2016: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/27861987/comparison-of-contrast-enhanced-ultrasonograpy-with-gd-eob-dtpa-enhanced-mri-in-the-diagnosis-of-liver-metastasis-from-colorectal-cancer
#4
Kazue Shiozawa, Manabu Watanabe, Takashi Ikehara, Yasushi Matsukiyo, Michio Kogame, Yoshinori Kikuchi, Yuichiro Otsuka, Hironori Kaneko, Yoshinori Igarashi, Yasukiyo Sumino
PURPOSE: To compare contrast-enhanced ultrasonography (CEUS) using Sonazoid with Gd-EOB-DTPA-enhanced MRI (EOB-MRI) in the diagnosis of liver metastases in patients with colorectal cancer. METHODS: A total of 69 patients diagnosed with or suspected of having liver metastasis were enrolled. These hepatic lesions were diagnosed by histopathological examination after surgical resection or based on follow-up using various imaging modalities. The diagnostic accuracies of CEUS and EOB-MRI were compared...
November 12, 2016: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/27858703/chronic-liver-disease-quantitative-mri-vs%C3%A2-ceus-based-microperfusion
#5
M Haimerl, S Poelsterl, L P Beyer, I Wiesinger, C Nießen, C Stroszczynski, P Wiggermann, E-M Jung
PURPOSE: To compare the diagnostic performance of MRI-based T1 relaxometry with dynamic contrast-enhanced ultrasound (CEUS)-based liver microcirculation for evaluation of liver function. MATERIALS AND METHODS: 22 patients underwent Gd-EOB-DTPA-enhanced MRI with T1 relaxometry and previous or consecutive CEUS examinations. A transverse 3D VIBE sequence with an inline T1 calculation was acquired and the reduction rate of T1 relaxation time (rrT1) was evaluated. For CEUS measurements (1-6 MHz), a bolus injection of 1...
November 18, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27842889/limitations-of-gd-eob-dtpa-enhanced-mri-can-clinical-parameters-predict-suboptimal-hepatobiliary-phase
#6
M Kobi, V Paroder, M Flusberg, A M Rozenblit, V Chernyak
AIM: To establish cut-off levels of the clinical parameters, which would predict suboptimal 30 minutes delayed hepatobiliary phase (HBP) with high specificity. MATERIALS AND METHODS: This retrospective study included patients with chronic liver disease who underwent hepatocellular carcinoma screening with Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) between 1 January 2011 and 30 November 2014. For each case, HBP was graded as adequate or suboptimal, based on Liver Image Reporting and Data System (LI-RADS) criteria...
November 11, 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27842668/hepatobiliary-phase-images-using-gadolinium-ethoxybenzyl-diethylenetriamine-penta-acetic-acid-enhanced-mri-as-an-imaging-surrogate-for-the-albumin-bilirubin-grading-system
#7
Yasuo Takatsu, Satoshi Kobayashi, Tosiaki Miyati, Toshiki Shiozaki
OBJECTIVES: To clarify the correlation between hepatobiliary phase (HBP) images using gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA) and albumin-bilirubin (ALBI) grading system. MATERIALS AND METHODS: We evaluated 220 consecutive patients who underwent liver magnetic resonance imaging with Gd-EOB-DTPA. Quantitative liver-spleen contrast ratio (Q-LSC) was calculated in HBP images approximately 20min after Gd-EOB-DTPA administration. To evaluate the degree of association between Q-LSC and ALBI grade, the Child-Pugh (C-P) score was used for comparison...
December 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27825780/demographic-and-clinical-differences-between-early-and-late-onset-bipolar-disorders-in-a-multicenter-study-in-china
#8
Ling Zhang, Hai-Chen Yang, Xiu-Feng Xu, Yi-Ru Fang, Xin Yu, Qing-Rong Tan, Hui-Chun Li, Gabor S Ungvari, Chee H Ng, Gang Wang, Yu-Tao Xiang
Little is known about the demographic and clinical differences between early-onset (EOB) and late-onset bipolar disorders (LOB) in Chinese patients. This multi-center study examined the demographic and clinical characteristics of EOB (≤21 years) and LOB (>21 years) in China. A consecutively recruited sample of 555 patients with bipolar disorder (BD) from 7 psychiatric hospitals and general hospital psychiatric units across China was examined. Patients' demographic and clinical characteristics were collected using a standardized protocol and data collection procedure...
October 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27787908/presence-of-non-hypervascular-hypointense-nodules-on-gd-eob-dtpa-enhanced-mri-in-patients-with-hepatocellular-carcinoma
#9
Masanori Inoue, Sadahisa Ogasawara, Tetsuhiro Chiba, Yoshihiko Ooka, Toru Wakamatsu, Kazufumi Kobayashi, Eiichiro Suzuki, Akinobu Tawada, Osamu Yokosuka
BACKGROUND AND AIMS: Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) performed before curative therapy for hepatocellular carcinoma (HCC) can distinguish between intrahepatic distant recurrence and hypervascularization. We aimed to retrospectively evaluate the presence of non-hypervascular hypointense nodules on hepatobiliary phase images (HBPI) from Gd-EOB-DTPA-enhanced MRI as a risk factor of the intrahepatic distant recurrence of early-stage HCC following radiofrequency ablation (RFA)...
October 27, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27785826/hepatic-function-imaging-using-dynamic-gd-eob-dtpa-enhanced-mri-and-pharmacokinetic-modeling
#10
Jia Ning, Zhiying Yang, Sheng Xie, Yongliang Sun, Chun Yuan, Huijun Chen
PURPOSE: To determine whether pharmacokinetic modeling parameters with different output assumptions of dynamic contrast-enhanced MRI (DCE-MRI) using Gd-EOB-DTPA correlate with serum-based liver function tests, and compare the goodness of fit of the different output assumptions. METHODS: A 6-min DCE-MRI protocol was performed in 38 patients. Four dual-input two-compartment models with different output assumptions and a published one-compartment model were used to calculate hepatic function parameters...
October 26, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27771842/central-vascular-structures-as-a-characteristic-finding-of-regenerative-nodules-using-hepatobiliary-phase-gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic-acid-enhanced-mri-and-arterial-dominant-phase-contrast-enhanced-us
#11
Kazuya Sugimori, Kazushi Numata, Masahiro Okada, Hiromi Nihonmatsu, Shigeo Takebayashi, Shin Maeda, Masayuki Nakano, Katsuaki Tanaka
OBJECTIVE: We investigated the characteristic findings of regenerative nodules (RNs) for differentiating early hepatocellular carcinoma (HCC) from high-grade dysplastic nodules (HGDNs) using magnetic resonance imaging (MRI) with gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA; EOB-MRI) and contrast-enhanced ultrasonography (CEUS) in patients with chronic liver disease. SUBJECTS AND METHODS: Pathologically confirmed lesions (100 early HCCs, 7 HGDNs, and 20 RNs with a maximum diameter of more than 1 cm and mean maximal diameters of 15...
October 22, 2016: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/27768617/performance-of-gadoxetic-acid-enhanced-liver-magnetic-resonance-imaging-for-predicting-patient-eligibility-for-liver-transplantation-based-on-the-milan-criteria
#12
Hwi Young Jang, Joon-Il Choi, Young Joon Lee, Michael Yong Park, Dong Myung Yeo, Sung Eun Rha, Eun Sun Jung, Young Kyoung You, Dong Goo Kim, Jae Young Byun
PURPOSE: This study aimed to evaluate the accuracy of gadoxetic acid-enhanced magnetic resonance imaging (Gd-EOB-MRI) in predicting eligibility for liver transplantation in patients with hepatocellular carcinoma (HCC) based on Milan criteria (MC). MATERIALS AND METHODS: We reviewed Gd-EOB-MRI of 44 patients who underwent liver transplantation for HCC with cirrhosis for the presence/size of HCCs, vascular invasion, and transplant eligibility based on MC. Hepatocellular carcinoma was diagnosed based on conventional radiological hallmarks (arterial enhancement and washout) or the modified criteria...
October 20, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27750237/comparison-of-contrast-enhanced-ultrasound-and-gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic-acid-enhanced-mri-for-the-diagnosis-of-macroscopic-type-of-hepatocellular-carcinoma
#13
Takayuki Iwamoto, Yasuharu Imai, Sachiyo Kogita, Takumi Igura, Yoshiyuki Sawai, Kazuto Fukuda, Yoshitaka Yamaguchi, Yasushi Matsumoto, Masanori Nakahara, Osakuni Morimoto, Yasushi Seki, Hiroshi Ohashi, Norihiko Fujita, Masatoshi Kudo, Tetsuo Takehara
OBJECTIVE: We compared the efficacy of contrast-enhanced ultrasound sonography (CEUS) with sonazoid and gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI for the assessment of macroscopic classification of nodular hepatocellular carcinoma (HCC). METHODS: Seventy-seven consecutive patients with 79 surgically resected HCCs who underwent both preoperative CEUS and Gd-EOB-DTPA-enhanced MRI were enrolled in this retrospective study...
2016: Digestive Diseases
https://www.readbyqxmd.com/read/27726242/washout-appearance-in-gd-eob-dtpa-enhanced-mr-imaging-a-differentiating-feature-between-hepatocellular-carcinoma-with-paradoxical-uptake-on-the-hepatobiliary-phase-and-focal-nodular-hyperplasia-like-nodules
#14
Jeong Woo Kim, Chang Hee Lee, Soo Byn Kim, Bit Na Park, Yang Shin Park, Jongmee Lee, Cheol Min Park
PURPOSE: To identify the most reliable imaging features for differentiating hepatocellular carcinoma with paradoxical uptake on the hepatobiliary phase (HCCpara ) from focal nodular hyperplasia (FNH)-like nodules using Gd-EOB-DTPA-enhanced MRI. MATERIALS AND METHODS: This was a retrospective study. Twenty patients with HCCpara and 21 patients with FNH-like nodules were included. The following MRI features were evaluated using 3.0 Tesla unit by two radiologists: signal intensity (SI) on T1-, T2-, and diffusion-weighted imaging (DWI), arterial enhancement pattern, washout appearance on the portal venous phase (PVP) and/or transitional phase (TP), uptake pattern on the hepatobiliary phase (HBP), "T2 scar," "EOB scar," and chemical shift on in- and out-of-phase images...
October 11, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27714420/3d-t2-weighted-and-gd-eob-dtpa-enhanced-3d-t1-weighted-mr-cholangiography-for-evaluation-of-biliary-anatomy-in-living-liver-donors
#15
Larry Cai, Benjamin M Yeh, Antonio C Westphalen, John Roberts, Zhen J Wang
PURPOSE: To investigate whether the addition of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced 3D T1-weighted MR cholangiography (T1w-MRC) to 3D T2-weighted MRC (T2w-MRC) improves the confidence and diagnostic accuracy of biliary anatomy in living liver donors. METHODS: Two abdominal radiologists retrospectively and independently reviewed pre-operative MR studies in 58 consecutive living liver donors. The second-order bile duct visualization on T1w- and T2w-MRC images was rated on a 4-point scale...
October 7, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27693670/-18-f-fluoro-azomycin-2%C3%A2-deoxy-%C3%AE-d-ribofuranoside-a-new-imaging-agent-for-tumor-hypoxia-in-comparison-with-18-f-faza
#16
Anna Schweifer, Florian Maier, Walter Ehrlichmann, Denis Lamparter, Manfred Kneilling, Bernd J Pichler, Friedrich Hammerschmidt, Gerald Reischl
INTRODUCTION: Radiolabeled 2-nitroimidazoles (azomycins) are a prominent class of biomarkers for PET imaging of hypoxia. [(18)F]Fluoro-azomycin-α-arabinoside ([(18)F]FAZA) - already in clinical use - may be seen as α-configuration nucleoside, but enters cells only via diffusion and is not transported by cellular nucleoside transporters. To enhance image contrast in comparison to [(18)F]FAZA our objective was to (18)F-radiolabel an azomycin-2´-deoxyriboside with β-configuration ([(18)F]FAZDR, [(18)F]-β-8) to mimic nucleosides more closely and comparatively evaluate it versus [(18)F]FAZA...
December 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/27682648/comparative-diagnostic-accuracy-of-hepatocyte-specific-gadoxetic-acid-gd-eob-dtpa-enhanced-mr-imaging-and-contrast-enhanced-ct-for-the-detection-of-liver-metastases-a-systematic-review-and-meta-analysis
#17
Thomas D Vreugdenburg, Ning Ma, Joanna K Duncan, Dagmara Riitano, Alun L Cameron, Guy J Maddern
PURPOSE: This systematic review evaluated the diagnostic accuracy and impact on patient management of hepatocyte-specific gadoxetic acid enhanced magnetic resonance imaging (GA-MRI) compared to contrast enhanced computed tomography (CE-CT) in patients with liver metastases. METHOD: Four biomedical databases (PubMed, EMBASE, Cochrane Library, York CRD) were searched from January 1991 to February 2016. Studies investigating the accuracy or management impact of GA-MRI compared to CE-CT in patients with known or suspected liver metastases were included...
November 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27674080/gd-eob-dtpa-enhanced-liver-magnetic-resonance-imaging-as-image-biomarker-for-assessment-of-liver-injury-after-external-beam-radiation-therapy
#18
X Sun, L Xing, S Yan, J Yu, X Dong, S Yuan, D Wang, L Bu, Z Lu, X Jiang, G Cao
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27673918/radiation-induced-liver-injury-after-3-dimensional-conformal-radiation-therapy-for-hepatocellular-carcinoma-quantitative-assessment-by-gd-eob-dtpa-enhanced-magnetic-resonance-imaging
#19
R Toya, Y Fukugawa, T Namimoto, T Saito, H Yuki, T Matsuyama, O Ikeda, Y Yamashita, N Oya
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27652261/immediate-adverse-reactions-to-gadolinium-based-mr-contrast-media-a-retrospective-analysis-on-10-608-examinations
#20
Vincenza Granata, Marco Cascella, Roberta Fusco, Nicoletta dell'Aprovitola, Orlando Catalano, Salvatore Filice, Vincenzo Schiavone, Francesco Izzo, Arturo Cuomo, Antonella Petrillo
Background and Purpose. Contrast media (CM) for magnetic resonance imaging (MRI) may determine the development of acute adverse reactions. Objective was to retrospectively assess the frequency and severity of adverse reactions associated with gadolinium-based contrast agents (GBCAs) injection in patients who underwent MRI. Material and Methods. At our center 10608 MRI examinations with CM were performed using five different GBCAs: Gd-BOPTA (MultiHance), Gd-DTPA (Magnevist), Gd-EOBDTPA (Primovist), Gd-DOTA (Dotarem), and Gd-BTDO3A (Gadovist)...
2016: BioMed Research International
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