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https://www.readbyqxmd.com/read/29146731/organic-anion-transporting-polypeptide-1b3-as-a-dual-reporter-gene-for-fluorescence-and-magnetic-resonance-imaging
#1
Menq-Rong Wu, Hon-Man Liu, Chen-Wen Lu, Way-Hone Shen, I-Jou Lin, Li-Wen Liao, Yi-You Huang, Ming-Jium Shieh, Jong-Kai Hsiao
Reporter proteins have broad applications in visualizing molecular events at the cellular, tissue and whole-body levels. Transmembrane transporters recognizing specific molecular domains are of particular interest because they enable the migration of signal-source molecules from the extracellular space to the cytoplasm for subsequent application in multimodality imaging. Organic anion-transporting polypeptides (OATPs) have demonstrated their MRI reporter efficacy. We further expanded their use as a dual-modality reporter in MRI and noninvasive in vivo imaging system (IVIS)...
November 16, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29138880/morphological-classification-of-intraductal-papillary-neoplasm-of-the-bile-duct
#2
Shihong Ying, Mingliang Ying, Wenjie Liang, Zhaoming Wang, Qidong Wang, Feng Chen, Wenbo Xiao
OBJECTIVES: To investigate the morphological classification of intraductal papillary neoplasm of the bile duct (IPNB), as well as morphological differences between IPNB without mucin secretion (IPNB-NM) and IPNB with mucin secretion (IPMN-B). METHODS: Eighty-one patients with IPNB were retrospectively analysed. Imaging examinations included computed tomography (CT), magnetic resonance imaging (MRI), gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced MRI and positron emission tomography-computed tomography (PET-CT)...
November 14, 2017: European Radiology
https://www.readbyqxmd.com/read/29127936/synthesis-of-n-3-4-11-c-methylpiperazin-1-yl-1-5-methylpyridin-2-yl-1h-pyrazol-5-yl-pyrazolo-1-5-a-pyrimidine-3-carboxamide-as-a-new-potential-pet-agent-for-imaging-of-irak4-enzyme-in-neuroinflammation
#3
Xiaohong Wang, Wenzhi Xu, Caihong Miao, Fugui Dong, Wei Li, Min Wang, Mingzhang Gao, Qi-Huang Zheng, Zhidong Xu
The reference standard N-(3-(4-methylpiperazin-1-yl)-1-(5-methylpyridin-2-yl)-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide (9) and its demethylated precursor N-(1-(5-methylpyridin-2-yl)-3-(piperazin-1-yl)-1H-pyrazol-5-yl)pyrazolo[1,5-α]pyrimidine-3-carboxamide (8) were synthesized from pyrazolo[1,5-a]pyrimidine-3-carboxylic acid and ethyl 2-cyanoacetate with overall chemical yield 13% in nine steps and 14% in eight steps, respectively. The target tracer N-(3-(4-[(11)C]methylpiperazin-1-yl)-1-(5-methylpyridin-2-yl)-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide ([(11)C]9) was prepared from its precursor with [(11)C]CH3OTf through N-[(11)C]methylation and isolated by HPLC combined with SPE in 50-60% radiochemical yield, based on [(11)C]CO2 and decay corrected to EOB...
November 6, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29049250/comparison-of-the-efficacy-of-gd-eob-dtpa-enhanced-magnetic-resonance-imaging-and-magnetic-resonance-elastography-in-the-detection-and-staging-of-hepatic-fibrosis
#4
Wen-Pei Wu, Cheng-In Hoi, Ran-Chou Chen, Ching-Po Lin, Chen-Te Chou
The present study compared the efficacy of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) and magnetic resonance elastography (MRE) in the estimation of hepatic fibrosis stages with histopathologic correlation.This retrospective study included 104 patients (87 men and 17 women; mean age, 60.6 ± 10.6 years) with chronic liver disease who underwent both Gd-EOB-DTPA-enhanced MRI and MRE. The relative enhancement (RE) ratio of the liver parenchyma and the contrast enhancement index (CEI) were calculated as (SIpostliver - SIpreliver)/SIpreliver and SIpost/SIpre, respectively, where SIpost and SIpre were the liver-to-muscle signal intensity ratios on the hepatobiliary phase images and noncontrast-enhanced images, respectively...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29040990/non-hypervascular-hypointense-hepatic-nodules-during-the-hepatobiliary-phase-of-gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic-acid-enhanced-mri-as-a-risk-factor-of-intrahepatic-distant-recurrence-after-radiofrequency-ablation-of-hepatocellular-carcinoma
#5
Takayuki Iwamoto, Yasuharu Imai, Takumi Igura, Sachiyo Kogita, Yoshiyuki Sawai, Kazuto Fukuda, Yoshitaka Yamaguchi, Yasushi Matsumoto, Masanori Nakahara, Osakuni Morimoto, Hiroshi Ohashi, Norihiko Fujita, Masatoshi Kudo, Tetsuo Takehara
BACKGROUND: Non-hypervascular hypointense hepatic nodules during the hepatobiliary phase of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI have been reported to be associated with intrahepatic distant recurrence (IDR) after hepatectomy or radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). IDR is categorized into hypervascular transformation of non-hypervascular hypointense hepatic nodules and new intrahepatic recurrence. The aim of this study was to evaluate the relationship between non-hypervascular hypointense hepatic nodules on Gd-EOB-DTPA-enhanced MRI and IDR after RFA, focusing on new intrahepatic recurrence...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29033416/progression-of-hepatic-hypovascular-nodules-with-hypointensity-in-the-hepatobiliary-phase-of-gd-eob-dtpa-enhanced-mri-in-hepatocellular-carcinoma-cases
#6
Tsukasa Saitoh, Shuichi Sato, Tomotaka Yazaki, Hiroshi Tobita, Tatsuya Miyake, Shunji Ishihara, Takashi Katsube, Hajime Kitagaki, Yoshikazu Kinoshita
Purpose We investigated the possible factors for predicting the future progression to hepatocellular carcinoma (HCC) from hypovascular nodules detected in the hepatobiliary phase of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging (Gd-EOB-DTPA-MRI). Material and Methods A total of 91 hypovascular nodules detected by Gd-EOB-DTPA-MRI in 28 patients without any past history of treatment for HCC were retrospectively examined. The nodules were categorized into those with and without HCC progression, then comparisons were made to identify any factors possibly related to a progression to HCC in each case...
October 16, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29029443/quantitative-evaluation-of-gd-eob-dtpa-uptake-in-focal-liver-lesions-by-using-t1-mapping-differences-between-hepatocellular-carcinoma-hepatic-focal-nodular-hyperplasia-and-cavernous-hemangioma
#7
Zhenpeng Peng, Chang Li, Tao Chan, Huasong Cai, Yanji Luo, Zhi Dong, Zi-Ping Li, Shi-Ting Feng
OBJECTIVES: To investigate the difference of T1 relaxation time on Gd-EOB-DTPA-enhanced MRI in hepatocellular carcinoma (HCC), hepatic focal nodular hyperplasia (FNH) and cavernous hemangioma of liver (CHL), and to quantitatively evaluate the uptake of Gd-EOB-DTPA in these three focal liver lesions (FLLs). RESULTS: The T1P of CHL was significantly higher than those of HCC and FNH (P < 0.05). Reduction of T1 relaxation time on hepatobiliary phase could be observed in all three types of lesions...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28990804/effects-of-a-blend-of-essential-oils-and-overcrowding-stress-on-the-growth-performance-meat-quality-and-heat-shock-protein-gene-expression-of-broilers
#8
S M Hosseini, H Farhangfar, R Nourmohammadi
1. Overcrowding stress is common in the poultry industry. Chickens exposed to long-term stressful situations are characterised by welfare impairment and immunosuppression. The present study evaluated the effects of a blend of essential oils (EOB; cinnamaldehyde and thymol) and stocking density on the performance, gut microflora, meat quality, and physiological stress markers of broilers. One-day-old Ross 308 male broiler chickens (n = 360) were allocated to 4 experimental groups from d 22 to 42. Each treatment had 6 replicates of 15 chicks...
October 9, 2017: British Poultry Science
https://www.readbyqxmd.com/read/28987688/differentiation-of-hypointense-nodules-on-gadoxetic-acid-enhanced-hepatobiliary-phase-mri-using-t2-enhanced-spin-echo-imaging-with-the-time-reversed-gradient-echo-sequence-an-initial-experience
#9
Masami Yoneyama, Yukihisa Takayama, Akihiro Nishie, Masanobu Nakamura, Yasutomo Katsumata, Atsushi Takemura, Makoto Obara, Tomoyuki Okuaki, Hiroshi Honda, Marc Van Cauteren
PURPOSE: To optimize the flip angle (FA) of the T2 enhanced spin-echo imaging using the time reversed gradient echo (T2FFE) and evaluate its utility for differentiating hypointensity nodules in the hepatobiliary phase (HBP) of gadoxetic acid-enhanced (Gd-EOB) MRI. MATERIALS AND METHODS: First, FA optimization of the T2FFE in the HBP was investigated by comparing signal-to-noise ratio (SNR) among different FAs using phantoms. The liver-to-muscle contrast ratios (CRLiver-Muscle) and image quality among three FAs (20°, 50° and 80°) were compared using images of 10 patients...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28982888/accurate-estimation-of-functional-liver-volume-using-gd-eob-dtpa-mri-compared-to-mdct-99m-tc-spect-fusion-imaging
#10
COMPARATIVE STUDY
Yuji Morine, Chinbold Enkhbold, Satoru Imura, Tetsuya Ikemoto, Syuichi Iwahashi, Y U Saito, Shinichiro Yamada, Tohru Utsunomiya, Mitsuo Shimada
BACKGROUND/AIM: We assessed the utility of dynamic magnetic resonance imaging (MRI) with gadoxetate-ethoxybenzyl-diethylenetriamine penta-aceticpenta-acetic acid (Gd-EOB-DTPA) (EOB-MRI) for estimating functional liver volume compared to (99m)Tc-galactosyl albumin single-photon-emission computed tomography ((99m)Tc-GSA SPECT). PATIENTS AND METHODS: Regional functional liver volume (left lateral, medial, right anterior, right posterior) of 58 hepatectomized patients was assessed using EOB-MRI and (99m)Tc-GSA SPECT, and compared to the actual liver volume with MDCT-3D volumetry...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28972915/comparison-between-18-f-fluorination-and-18-f-fluoroethylation-reactions-for-the-synthesis-of-the-pde10a-pet-radiotracer-18-f-mni-659
#11
Wakana Mori, Makoto Takei, Kenji Furutsuka, Masayuki Fujinaga, Katsushi Kumata, Masatoshi Muto, Takayuki Ohkubo, Hiroki Hashimoto, Gilles Tamagnan, Makoto Higuchi, Kazunori Kawamura, Ming-Rong Zhang
INTRODUCTION: 2-(2-(3-(4-(2-[(18)F]Fluoroethoxy)phenyl)-7-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)-4-isopropoxyisoindoline-1,3-dione ([(18)F]MNI-659, [(18)F]1) is a useful PET radiotracer for imaging phosphodiesterase 10A (PDE10A) in human brain. [(18)F]1 has been previously prepared by direct [(18)F]fluorination of a tosylate precursor 2 with [(18)F]F(-). The aim of this study was to determine the conditions for the [(18)F]fluorination reaction to obtain [(18)F]1 of high quality and with sufficient radioactivity for clinical use in our institute...
August 25, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28946101/cyclotron-production-and-radiochemical-separation-of-55-co-and-58m-co-from-54-fe-58-ni-and-57-fe-targets
#12
H F Valdovinos, R Hernandez, S Graves, P A Ellison, T E Barnhart, C P Theuer, J W Engle, W Cai, R J Nickles
This work presents the production with a cyclotron of the positron emitter (55)Co via the (54)Fe(d,n) and (58)Ni(p,α) reactions and the Auger electron emitter (58m)Co via the (57)Fe(d,n) reaction after high current (40μA p and 60μA d) irradiation on electroplated targets. High specific activity radionuclides (up to 55.6 GBq/μmol (55)Co and 31.8GBq/μmol (58m)Co) with high radionuclidic purity (99.995% (55)Co from (54)Fe, 98.8% (55)Co from (58)Ni, and 98.7% (58m)Co from (57)Fe at end of bombardment, EoB), in high activity concentration (final separated radionuclide in < 0...
December 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28902734/incidental-detection-of-hepatocellular-carcinoma-on-68ga-labeled-prostate-specific-membrane-antigen-pet-ct
#13
D Patel, H Loh, K Le, A Stevanovic, R Mansberg
A 66-year-old man with history of prostate carcinoma underwent Ga-labeled prostate-specific membrane antigen PET/CT for surveillance of rising prostate-specific antigen. Intense tracer uptake was noted in segments 2, 7, and 8 of the liver. The lesions were not FDG avid on F-FDG PET/CT. Further characterization with magnetic resonance cholangiopancreatography with Gd-EOB (Primovist) contrast revealed ill-defined arterially enhancing lesions with central washout in the venous phase. CT-guided core biopsy was performed, and histopathology confirmed well-differentiated hepatocellular carcinoma...
September 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28895045/influence-of-gd-eob-dtpa-on-proton-density-fat-fraction-using-the-six-echo-dixon-method-in-3-tesla-magnetic-resonance-imaging
#14
Tatsuya Hayashi, Kei Fukuzawa, Hiroshi Kondo, Hiroshi Onodera, Shuji Toyotaka, Rie Tojo, Shimpei Yano, Masakatsu Tano, Tosiaki Miyati, Jun'ichi Kotoku, Takahide Okamoto, Keiko Toyoda, Hiroshi Oba
The purpose of this study was to evaluate whether disodium gadoxetate (Gd-EOB-DTPA) affects proton density fat fractions (PDFFs) during use of the multiecho Dixon (meDixon) method in phantom and simulation magnetic resonance imaging (MRI) studies at 3 T. Fat-water phantoms comprising vegetable fat-water emulsions with varying fat volume percentages (0, 5, 10, 15, 20, 30, 40, and 50) and Gd-EOB-DTPA concentrations (0 and 0.4 mM) were prepared. Phantoms without Gd-EOB-DTPA were defined as precontrast, and those with Gd-EOB-DTPA were defined as postcontrast...
September 11, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/28886231/gadoxetic-acid-enhanced-mri-outperformed-mdct-in-diagnosing-small-hepatocellular-carcinoma-a-meta-analysis
#15
Xijiao Liu, Hanyu Jiang, Jie Chen, You Zhou, Zixing Huang, Bin Song
Early detection of small hepatocellular carcinoma (HCC) lesions can improve long-term patient survival. A systematic review and meta-analysis of the diagnostic performance of gadoxetic acid disodium-enhanced magnetic resonance imaging (Gd-EOB-DTPA-enhanced MRI) and multidetector computed tomography (MDCT) was performed in diagnosing small HCCs measuring up to 2 cm(≤2cm). Two investigators searched multiple databases for studies in which the performances of either Gd-EOB-DTPA-enhanced MRI or MDCT were reported with sufficient data to construct 2 × 2 contingency tables for diagnosing HCCs up to 2 cm on a per-lesion or per-patient level...
September 8, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28881643/critical-analysis-of-the-major-and-ancillary-imaging-features-of-li-rads-on-127-proven-hccs-evaluated-with-functional-and-morphological-mri-lights-and-shadows
#16
Vincenza Granata, Roberta Fusco, Antonio Avallone, Francesco Filice, Fabiana Tatangelo, Mauro Piccirillo, Roberto Grassi, Francesco Izzo, Antonella Petrillo
PURPOSE: To report a critical analysis of major and ancillary MR imaging features in assessment of HCC. METHODS: Retrospectively we evaluated 70 cirrhotic patients with 173 nodules, which were subjected to MR study at 0 time (MR0), after 3 (MR3) and 6 months (MR6) using two different contrast media. EOB-GD-DTPA was injected at MR0 and MR6, while Gd-BT-DO3A at MR3. Three expert hepatic radiologists reviewed all images, recording, according to LI-RADS, the size, the presence and quality of arterial-phase hyperenhancement, washout and capsule appearance, threshold growth...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28876456/management-of-disappearing-lesions-after-chemotherapy-for-colorectal-liver-metastases-relation-between-detectability-and-residual-tumors
#17
Keigo Tani, Junichi Shindoh, Nobuhisa Akamatsu, Junichi Arita, Junichi Kaneko, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo
BACKGROUND AND OBJECTIVES: To clarify the detectability of gadolinium ethoxybenzyl diethylene-triamine pantaacetic acid enhanced magnetic resonance imaging (EOB-MRI) and contrast-enhanced intraoperative-ultrasonography (CE-IOUS) for residual disease in disappearing colorectal liver metastases (DLMs) and to seek a better management for DLMs. METHODS: Eighty-two patients who underwent hepatectomy after chemotherapy for colorectal liver metastases were retrospectively reviewed...
September 6, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28853292/prediction-of-high-stage-liver-fibrosis-using-adc-value-on-diffusion-weighted-imaging-and-quantitative-enhancement-ratio-at-the-hepatobiliary-phase-of-gd-eob-dtpa-enhanced-mri-at-1-5%C3%A2-t
#18
Taiyo L Harada, Kazuhiro Saito, Yoichi Araki, Jun Matsubayashi, Toshitaka Nagao, Katsutoshi Sugimoto, Koichi Tokuuye
Background Recently, diffusion-weighted imaging (DWI) and quantitative enhancement ratio measured at the hepatobiliary phase (HBP) of Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) has been established as an effective method for evaluating liver fibrosis. Purpose To evaluate which is a more favorable surrogate marker in predicting high-stage liver fibrosis, apparently diffusion coefficient (ADC) value or quantitative enhancement ratio measured on HBP. Material and Methods Eighty-three patients with 99 surgically resected hepatic lesions were enrolled in this study...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28842662/low-tube-voltage-liver-mdct-with-sinogram-affirmed-iterative-reconstructions-for-the-detection-of-hepatocellular-carcinoma
#19
B Pregler, L P Beyer, A Teufel, C Niessen, C Stroszczynski, H Brodoefel, P Wiggermann
Aim of this study was to compare low tube voltage computed tomography (80 kV) of the liver using iterative image reconstruction (SAFIRE) with standard computed tomography (120 kV) using filtered back-projection (FBP) for the detection of hepatocellular carcinoma (HCC). 46 patients (43 men) with 93 HCC confirmed by 3 T MRI with Gd-EOB-DPTA, in inconclusive cases combined with contrast-enhanced ultrasound, underwent dual-energy CT. The raw data of the 80 kV tube was reconstructed using the iterative reconstruction algorithm SAFIRE with two strengths (I3 and I5)...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28816953/peritumoral-decreased-uptake-area-of-gadoxetic-acid-enhanced-magnetic-resonance-imaging-and-tumor-recurrence-after-surgical-resection-in-hepatocellular-carcinoma-a-strobe-compliant-article
#20
Seung Kak Shin, Yun Soo Kim, Young Sup Shim, Seung Joon Choi, So Hyun Park, Dong Hae Jung, Oh Sang Kwon, Duck Joo Choi, Ju Hyun Kim
Recently, it has been suggested that peritumoral decreased uptake area (PDUA) in the hepatobiliary phase (HBP) of gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) was associated with vascular invasion in hepatocellular carcinoma (HCC). We aimed to investigate correlations between microvascular invasion and PDUA, and elucidate the predictability of PDUA for tumor recurrence after resection.We retrospectively analyzed clinicopathological and radiological data from 126 consecutive patients with single HCC ≤5 cm without macrovascular invasion who underwent preoperative Gd-EOB-DTPA-enhanced MRI and surgical resection...
August 2017: Medicine (Baltimore)
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