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https://www.readbyqxmd.com/read/28445909/transient-severe-motion-artifact-related-to-gadoxetate-disodium-enhanced-liver-mri-frequency-and-risk-evaluation-at-a-german-institution
#1
Lennart Well, Vanessa Hanna Rausch, Gerhard Adam, Frank Oliver Henes, Peter Bannas
Purpose Varying frequencies (5 - 18 %) of contrast-related transient severe motion (TSM) imaging artifacts during gadoxetate disodium-enhanced arterial phase liver MRI have been reported. Since previous reports originated from the United States and Japan, we aimed to determine the frequency of TSM at a German institution and to correlate it with potential risk factors and previously published results. Materials and Methods Two age- and sex-matched groups were retrospectively selected (gadoxetate disodium n = 89; gadobenate dimeglumine n = 89) from dynamic contrast-enhanced MRI examinations in a single center...
April 26, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28368880/critical-questions-regarding-gadolinium-deposition-in-the-brain-and-body-after-injections-of-the-gadolinium-based-contrast-agents-safety-and-clinical-recommendations-in-consideration-of-the-ema-s-pharmacovigilance-and-risk-assessment-committee-recommendation
#2
Val M Runge
For magnetic resonance, the established class of intravenous contrast media is the gadolinium-based contrast agents. In the 3 decades since initial approval, these have proven in general to be very safe for human administration. However, in 2006, a devastating late adverse reaction to administration of the less stable gadolinium-based contrast agents was identified, nephrogenic systemic fibrosis. The result of actions taken by the European Medicines Agency and the US Food and Drug Administration, stratifying the agents by risk and contraindicating specific agents in severe renal dysfunction, has led to no new cases being identified in North America or Europe...
June 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28348578/contrast-enhanced-magnetic-resonance-cholangiography-practical-tips-and-clinical-indications-for-biliary-disease-management
#3
REVIEW
Stefano Palmucci, Federica Roccasalva, Marina Piccoli, Giovanni Fuccio Sanzà, Pietro Valerio Foti, Alfonso Ragozzino, Pietro Milone, Giovanni Carlo Ettorre
Since its introduction, MRCP has been improved over the years due to the introduction of several technical advances and innovations. It consists of a noninvasive method for biliary tree representation, based on heavily T2-weighted images. Conventionally, its protocol includes two-dimensional single-shot fast spin-echo images, acquired with thin sections or with multiple thick slabs. In recent years, three-dimensional T2-weighted fast-recovery fast spin-echo images have been added to the conventional protocol, increasing the possibility of biliary anatomy demonstration and leading to a significant benefit over conventional 2D imaging...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28125438/quantification-and-assessment-of-the-chemical-form-of-residual-gadolinium-in-the-brain-after-repeated-administration-of-gadolinium-based-contrast-agents-comparative-study-in-rats
#4
Thomas Frenzel, Chirag Apte, Gregor Jost, Laura Schöckel, Jessica Lohrke, Hubertus Pietsch
OBJECTIVE: Multiple clinical and preclinical studies have reported a signal intensity increase and the presence of gadolinium (Gd) in the brain after repeated administration of Gd-based contrast agents (GBCAs). This bioanalytical study in rat brain tissue was initiated to investigate whether the residual Gd is present as intact GBCA or in other chemical forms by using tissue fractionation and chromatography. MATERIALS AND METHODS: Rats were divided randomly in 6 groups of 10 animals each...
January 25, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/27929673/effect-of-gadoxetate-disodium-on-arterial-phase-respiratory-waveforms-using-a-quantitative-fast-fourier-transformation-based-analysis
#5
Matthew S Davenport, Dariya I Malyarenko, Yuxi Pang, Hero K Hussain, Thomas L Chenevert
OBJECTIVE: The purpose of this study is to investigate the effect of gadoxetate disodium administration on arterial phase respiratory waveforms. SUBJECTS AND METHODS: From 2013 to 2015, 107 subjects undergoing liver MRI with either gadoxetate disodium (10 mL diluted 1:1 with saline; injection rate, 2 mL/s; n = 40) or gadobenate dimeglumine (0.2 mL/kg; maximum, 20 mL; injection rate, 2 mL/s; n = 67) were enrolled. Respiratory waveforms obtained during unenhanced and dynamic contrast-enhanced phases were filtered by a physicist, who was blinded to contrast agent and imaging phase, to eliminate electronic and cardiac noise using fast Fourier transformation...
February 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27862577/crossover-comparison-of-ferumoxytol-and-gadobenate-dimeglumine-for-abdominal-mr-angiography-at-3-0-tesla-effects-of-contrast-bolus-length-and-flip-angle
#6
Tilman Schubert, Utaroh Motosugi, Sonja Kinner, Timothy J Colgan, Samir D Sharma, Scott Hetzel, Shane Wells, Camilo A Campo, Scott B Reeder
PURPOSE: Ferumoxytol (FE) has gained interest as an alternative to gadolinium-based contrast agents (GBCAs). The purpose of this study was to evaluate and optimize ferumoxytol dose and T1 weighting, in comparison to a conventional GBCA. MATERIALS AND METHODS: Twelve healthy volunteers (six women / six men, mean age 44.3 years) were recruited for this study. Scanning was performed on a clinical 3 Tesla (T) MRI system. Gadobenate dimeglumine (GD)-enhanced MRA was performed followed by FE-enhanced MRA 1 month later...
June 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27824664/is-carotid-plaque-contrast-enhancement-on-mri-predictive-for-cerebral-or-cardiovascular-events-a-prospective-cohort-study
#7
Giacomo Davide Edoardo Papini, Giovanni Di Leo, Michele Bandirali, Biagio Cotticelli, Nicola Flor, Pietro Restivo, Giovanni Nano, Francesco Sardanelli
OBJECTIVE: The aim of this study was to correlate carotid plaque contrast enhancement (CPCE) to onset of cerebral/cardiovascular events (CCVE) in patients with atherosclerotic carotid disease. METHODS: The ethics committee approved this prospective study. Patients with carotid artery stenosis underwent magnetic resonance angiography before/after injection of 0.1 mmol/kg of gadobenate dimeglumine. Carotid plaque contrast enhancement was graded as follows: 0, no CPCE; 1, 1 single enhancement focus; 2, 2 or more foci...
March 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27778300/liver-perfusion-modifies-gd-dtpa-and-gd-bopta-hepatocyte-concentrations-through-transfer-clearances-across-sinusoidal-membranes
#8
Jean-Luc Daire, Benjamin Leporq, Valérie Vilgrain, Bernard E Van Beers, Sabine Schmidt, Catherine M Pastor
BACKGROUND AND OBJECTIVES: Gadobenate dimeglumine (Gd-BOPTA) is a commercialised hepatobiliary contrast agent used during liver magnetic resonance imaging (MRI) to detect liver diseases. It enters into human hepatocytes through organic anion transporting polypeptides (OATP1B1/B3) and crosses the canalicular transporter multiple resistance-associated protein 2 (MRP2) to be excreted into bile canaliculi. Gd-BOPTA can return to sinusoids via the sinusoidal transporters MRP3/MRP4. Hepatocyte concentrations of Gd-BOPTA depend on three clearances: the sinusoidal clearance or volume of sinusoidal blood cleared of drugs per unit of time and two hepatocyte clearances (into bile canaliculi or back to sinusoids) or volume of hepatocytes cleared of drugs per unit of time in the respective liver compartments...
October 24, 2016: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/27736700/transient-arterial-phase-respiratory-motion-related-artifact-in-mr-imaging-of-the-liver-an-analysis-of-four-different-gadolinium-based-contrast-agents
#9
Mansi R Shah, Milana Flusberg, Viktoriya Paroder, Alla M Rozenblit, Victoria Chernyak
PURPOSE: The purpose was to compare hepatic arterial phase (HAP) respiratory motion artifact (RMA) between gadoxetate, gadobutrol, gadopentetate, and gadobenate. MATERIALS/METHODS: Two hundred cases of each gadolinium agent were included. RMA was assigned using 5-point Likert scale (1=no motion, 5=extreme motion) on precontrast and HAP. RMA increase (increase ≥1 on HAP from precontrast) was the outcome in logistic regression. RESULTS: Odds of RMA increase for gadoxetate were 5...
January 2017: Clinical Imaging
https://www.readbyqxmd.com/read/27680411/evaluation-of-hepatocellular-carcinoma-tumor-response-after-transcatheter-arterial-chemoembolization-using-gadobenate-dimeglumine-enhanced-liver-magnetic-resonance
#10
RANDOMIZED CONTROLLED TRIAL
Linda C Chu, Chiara Pozzessere, Celia Pamela Corona-Villalobos, Sandra Castaños, Neda Rastegar, Vivek Halappa, Susanne Bonekamp, Emi Emurano, Ihab R Kamel
OBJECTIVE: Use of gadobenate dimeglumine-enhanced liver magnetic resonance (MR) for evaluation of hepatocellular carcinoma tumor response after transcatheter arterial chemoembolization (TACE). METHODS: Forty-five patients with hepatocellular carcinoma were imaged with multiphase gadobenate dimeglumine-enhanced MR examination at baseline and 1-month follow-up after TACE. Nodule size, enhancement, and apparent diffusion coefficient were measured for both examinations by 2 reviewers...
November 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27649101/delayed-gadolinium-enhanced-mr-imaging-of-cartilage-a-comparative-analysis-of-different-gadolinium-based-contrast-agents-in-an-ex-vivo-porcine-model
#11
Yusuhn Kang, Ja-Young Choi, Hye Jin Yoo, Sung Hwan Hong, Heung Sik Kang
Purpose To compare the delayed gadolinium-enhanced magnetic resonance (MR) imaging of cartilage (dGEMRIC) indexes acquired with different gadolinium-based contrast agents (GBCAs), with emphasis on the difference in electrical charge, and to evaluate the feasibility of the use of GBCAs other than gadopentetate dimeglumine with a double negative charge (Gd-DTPA(2-)) as alternatives at dGEMRIC. Materials and Methods Intact porcine patellae (n = 44) were divided into four groups according to GBCA used: Gd-DTPA(2-), double negative gadobenate dimeglumine (Gd-BOPTA(2-)), single negative gadoterate meglumine (Gd-DOTA(-)), and nonionic gadobutrol (Gd-DT-DO3A)...
March 2017: Radiology
https://www.readbyqxmd.com/read/27638667/high-and-ultrahigh-field-magnetic-resonance-imaging-of-na%C3%A3-ve-injured-and-scarred-vocal-fold-mucosae-in-rats
#12
Ayami Ohno Kishimoto, Yo Kishimoto, David L Young, Jinjin Zhang, Ian J Rowland, Nathan V Welham
Subepithelial changes to the vocal fold mucosa, such as fibrosis, are difficult to identify using visual assessment of the tissue surface. Moreover, without suspicion of neoplasm, mucosal biopsy is not a viable clinical option, as it carries its own risk of iatrogenic injury and scar formation. Given these challenges, we assessed the ability of high- (4.7 T) and ultrahigh-field (9.4 T) magnetic resonance imaging to resolve key vocal fold subepithelial tissue structures in the rat, an important and widely used preclinical model in vocal fold biology...
November 1, 2016: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/27633725/respiratory-motion-artefacts-in-liver-mri-following-injection-of-gadoxetate-disodium-and-gadobenate-dimeglumine-an-intra-individual-comparative-study-in-cirrhotic-patients
#13
COMPARATIVE STUDY
A Furlan, O N Close, A A Borhani, Y H Wu, M T Heller
AIM: To perform an intra-individual comparison of the frequency of respiratory-motion artefacts on magnetic resonance imaging (MRI) in cirrhotic patients following injection of gadoxetate disodium and gadobenate dimeglumine. MATERIALS AND METHODS: Ninety-five cirrhotic patients (61 men and 34 women, mean age 58 years) underwent liver MRI with intravenous administration of gadoxetate disodium and gadobenate dimeglumine at different times (interval between studies, 189±83 days)...
January 2017: Clinical Radiology
https://www.readbyqxmd.com/read/27618326/liver-mr-imaging-in-children-current-concepts-and-technique
#14
Govind B Chavhan, Susan Shelmerdine, Kartik Jhaveri, Paul S Babyn
Magnetic resonance (MR) imaging is increasingly being used for comprehensive evaluation of liver diseases in children because of the lack of radiation and better lesion detection and characterization. Liver examination involves routine sequences such as T2-weighted, balanced steady-state free precession, and in-phase and out-of-phase sequences. Dynamic imaging is an essential component of liver examination to characterize focal lesions and involves capturing snapshots of the passage of contrast material in the arterial, portal venous, equilibrium, and sometimes hepatobiliary phases, generally by using T1-weighted three-dimensional gradient-echo sequences...
September 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27576457/combined-blood-pool-and-extracellular-contrast-agents-for-pediatric-and-young-adult-cardiovascular-magnetic-resonance-imaging
#15
Joyce T Johnson, Joshua D Robinson, Jie Deng, Cynthia K Rigsby
BACKGROUND: A comprehensive cardiac magnetic resonance (cardiac MR) study including both late gadolinium enhancement (LGE) and MR angiography may be indicated for patients with a history of acquired or congenital heart disease. OBJECTIVE: To study the novel use of an extracellular agent for assessment of LGE combined with a blood pool contrast agent for detailed MR angiography evaluation to yield a comprehensive cardiac MR study in these patients. MATERIALS AND METHODS: We reviewed clinical cardiac MR studies utilizing extracellular and blood pool contrast agents and noted demographics, clinical data and adverse events...
December 2016: Pediatric Radiology
https://www.readbyqxmd.com/read/27436014/enhancement-of-abdominal-structures-on-mri-at-1-5-and-3-t-a-retrospective-intraindividual-crossover-comparison
#16
COMPARATIVE STUDY
Mamdoh AlObaidy, Miguel Ramalho, Fernanda Velloni, António P Matos, Kevin Herman, Richard C Semelka
OBJECTIVE: To quantitatively compare the extent of enhancement of abdominal structures on MRI in an intraindividual fashion at 1.5 and 3 T. METHODS: HIPAA-compliant, retrospective, longitudinal, intraindividual, crossover study, with waived informed consent, of consecutive individuals scanned at both 1.5 and 3 T closed-bore magnets using gadobenate dimeglumine during different phases of enhancement at tightly controlled arterial phase timing. Quantitative ROI measurements and qualitative sub-phase arterial phase assignments were independently performed by two radiologists...
April 2017: European Radiology
https://www.readbyqxmd.com/read/27373976/effectiveness-of-a-high-relaxivity-contrast-agent-administered-at-half-dose-in-dynamic-susceptibility-contrast-mri-of-brain-gliomas
#17
Girolamo Crisi, Silvano Filice, Gunter Erb, Francesca Bozzetti
PURPOSE: To determine whether half of the approved dose of gadobenate dimeglumine (MultiHance) is as effective as a full dose of gadoterate meglumine (Dotarem) for qualitative and quantitative cerebral blood volume (CBV) perfusion evaluation at 3T in patients with brain gliomas. MATERIALS AND METHODS: We enrolled 65 adult patients in an interindividual comparative study. Patients were randomized to one of two study arms: 33 patients received 0.1 mmol/kg body weight (bw) of gadoterate, 32 patients received 0...
February 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27304717/effects-of-height-and-blood-volume-on-venous-enhancement-after-gadolinium-based-contrast-administration-in-mr-venography-a-paradigm-challenge-and-implications-for-clinical-imaging
#18
Seena Dehkharghani, T Richard Williams, Deqiang Qiu, Amit M Saindane
OBJECTIVE: The purpose of this study was to analyze quantitative and qualitative effects of estimated blood volume on venous enhancement in patients undergoing cerebral MR venography (MRV) with standard weight-based dosing of a gadolinium-based contrast agent. MATERIALS AND METHODS: Fifty-two patients with normal 1.5-T cerebral MRV findings and contemporaneous height and weight measurements were included. Estimated blood volume was calculated with the Nadler formula for blood volume...
September 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27299482/gadoxetic-acid-enhanced-mri-for-the-characterization-of-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#19
Joanna K Duncan, Ning Ma, Thomas D Vreugdenburg, Alun L Cameron, Guy Maddern
PURPOSE: To establish the relative diagnostic accuracy of gadoxetic acid-enhanced magnetic resonance imaging (GA-MRI) compared with contrast-enhanced computed tomography (CE-CT), dynamic MRI (D-MRI), gadopentetic acid-enhanced MRI (GP-MRI), or gadobenic acid-enhanced MRI (GB-MRI) in the characterization of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: PubMed, EMBASE, the Cochrane Library, and the University of York CRD databases were searched to February 29 2016 for any studies that compared the diagnostic accuracy of GA-MRI to CE-CT, D-MRI, GP-MRI, or GB-MRI in patients with known or suspected HCC...
January 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27298076/a-liposomal-gd-contrast-agent-does-not-cross-the-mouse-placental-barrier
#20
Anil N Shetty, Robia Pautler, Ketan Ghagahda, David Rendon, Haijun Gao, Zbigniew Starosolski, Rohan Bhavane, Chandreshkumar Patel, Ananth Annapragada, Chandrasekhar Yallampalli, Wesley Lee
The trans-placental permeability of liposomal Gadolinium (Gd) nanoparticle contrast agents was evaluated in a pregnant mouse model. Pregnant Balb/c mice at 16.5 (±1) days of gestation were imaged using a 3D Spoiled Gradient Echo method at 9.4 T using two contrast agents: a clinically approved Gd chelate, Multihance(®) (gadobenate dimeglumine), and a novel experimental liposomal Gd agent. A Dynamic Contrast Enhancement (DCE) protocol was used to capture the dynamics of contrast entry and distribution in the placenta, and clearance from circulation...
2016: Scientific Reports
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