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Gadobenate

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https://www.readbyqxmd.com/read/29629800/comparison-of-visualization-rates-of-li-rads-version-2014-major-features-with-iv-gadobenate-dimeglumine-or-gadoxetate-disodium-in-patients-at-risk-for-hepatocellular-carcinoma
#1
Brian C Allen, Lisa M Ho, Tracy A Jaffe, Chad M Miller, Maciej A Mazurowski, Mustafa R Bashir
OBJECTIVE: The purpose of this study is to compare visualization rates of the major features covered by Liver Imaging Reporting and Data System (LI-RADS) version 2014 in patients at risk for hepatocellular carcinoma using either gadobenate dimeglumine or gadoxetate disodium IV contrast agent. MATERIALS AND METHODS: This retrospective study included liver MRI examinations performed with either gadobenate dimeglumine or gadoxetate disodium contrast enhancement. Using age, sex, underlying liver disease, and presence of cirrhosis, patients were placed into matched cohorts...
April 9, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29559761/myocardial-t1-mapping-and-determination-of-partition-coefficients-at-3-tesla-comparison-between-gadobenate-dimeglumine-and-gadofosveset-trisodium
#2
Marcelo Souto Nacif, Fabio S Raman, Neville Gai, Jacquin Jones, Rob J van der Geest, Christopher T Sibley, Songtao Liu, A Bluemke David
Objective: To compare an albumin-bound gadolinium chelate (gadofosveset trisodium) and an extracellular contrast agent (gadobenate dimeglumine), in terms of their effects on myocardial longitudinal (T1) relaxation time and partition coefficient. Materials and Methods: Study subjects underwent two imaging sessions for T1 mapping at 3 tesla with a modified look-locker inversion recovery (MOLLI) pulse sequence to obtain one pre-contrast T1 map and two post-contrast T1 maps (mean 15 and 21 min, respectively)...
January 2018: Radiologia Brasileira
https://www.readbyqxmd.com/read/29470193/breakthrough-reactions-to-gadobenate-dimeglumine
#3
Zeeshaan S Bhatti, Benjamin M Mervak, Jonathan R Dillman, Matthew S Davenport
PURPOSE: The aim of this study was to determine the severity of breakthrough reactions to gadobenate dimeglumine in patients premedicated with a 13-hour premedication regimen. METHODS: Institutional review board approval was obtained and informed consent waived for this Health Insurance Portability and Accountability Act-compliant retrospective cohort study. All acute allergic-like reactions to gadobenate dimeglumine from 11/1/2008 to 1/31/2016 were identified. Of these, 19 allergic-like reactions followed 13-hour premedication: 150 mg prednisone and 50 mg diphenhydramine (ie, "breakthrough reactions")...
February 21, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29419400/high-signal-intensity-in-the-dentate-nucleus-and-globus-pallidus-on-unenhanced-t1-weighted-mr-images-comparison-between-gadobutrol-and-linear-gadolinium-based-contrast-agents
#4
F G Moser, C T Watterson, S Weiss, M Austin, J Mirocha, R Prasad, J Wang
BACKGROUND AND PURPOSE: In view of the recent observations that gadolinium deposits in brain tissue after intravenous injection, our aim of this study was to compare signal changes in the globus pallidus and dentate nucleus on unenhanced T1-weighted MR images in patients receiving serial doses of gadobutrol, a macrocyclic gadolinium-based contrast agent, with those seen in patients receiving linear gadolinium-based contrast agents. MATERIALS AND METHODS: This was a retrospective analysis of on-site patients with brain tumors...
February 1, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29369947/hepatocellular-carcinoma-retrospective-evaluation-of-the-correlation-between-gadobenate-dimeglumine-enhanced-magnetic-resonance-imaging-and-pathologic-grade
#5
Xiuzhu Huang, Zebin Xiao, Yuyang Zhang, Na Lin, Meilian Xiong, Xinyao Huang, Qi Chen, Dairong Cao
OBJECTIVE: The aim of this study was to evaluate the usefulness of gadobenate dimeglumine-enhanced magnetic resonance imaging in characterizing the grade of hepatocellular carcinoma (HCC) using the signal intensity (SI) of the erector spinae as internal reference. MATERIALS AND METHODS: Clinical data of 40 patients (a total of 44 lesions) confirmed by pathology for HCC were retrospectively reviewed. Gadobenate dimeglumine-enhanced magnetic resonance imaging was performed in all patients, and SI of lesions (SIles), liver parenchyma around the lesions (SIhep), erector spinae (SImus) and standard deviation of SI of the surrounding noise (SDnoi) on nonenhanced T2WI, nonenhanced T1WI, and contrast-enhanced T1WI (in both arterial and hepatobiliary phase [AP and HBP]) were measured, respectively...
January 24, 2018: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29348135/development-of-high-signal-intensity-within-the-globus-pallidus-and-dentate-nucleus-following-multiple-administrations-of-gadobenate-dimeglumine
#6
G M Bolles, M Yazdani, S T Stalcup, S G Creeden, H R Collins, P J Nietert, D R Roberts
BACKGROUND AND PURPOSE: Previous studies have evaluated various gadolinium based contrast agents and their association with gadolinium retention, however, there is a discrepancy in the literature concerning the linear agent gadobenate dimeglumine. Our aim was to determine whether an association exists between the administration of gadobenate dimeglumine and the development of intrinsic T1-weighted signal in the dentate nucleus and globus pallidus. MATERIALS AND METHODS: In this single-center, retrospective study, the signal intensity of the globus pallidus, dentate nucleus, thalamus, and middle cerebellar peduncle was measured on unenhanced T1-weighted images in 29 adult patients who had undergone multiple contrast MRIs using exclusively gadobenate dimeglumine (mean, 10...
January 18, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29339139/improved-coronary-magnetic-resonance-angiography-using-gadobenate-dimeglumine-in-pediatric-congenital-heart-disease
#7
Miguel Silva Vieira, Markus Henningsson, Nathalie Dedieu, Vassilios S Vassiliou, Aaron Bell, Sujeev Mathur, Kuberan Pushparajah, Carlos Alberto Figueroa, Tarique Hussain, René Botnar, Gerald F Greil
BACKGROUND: CMRA in pediatrics remains challenging due to the smaller vessel size, high heart rates (HR), potential image degradation caused by limited patient cooperation and long acquisition times. High-relaxivity contrast agents have been shown to improve coronary imaging in adults, but limited data is available in children. We sought to investigate whether gadobenate dimeglumine (Gd-BOPTA) together with self-navigated inversion-prepared coronary magnetic resonance angiography (CMRA) sequence design improves coronary image quality in pediatric patients...
January 12, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29329151/gadolinium-retention-brain-t1-hyperintensity-and-endogenous-metals-a-comparative-study-of-macrocyclic-versus-linear-gadolinium-chelates-in-renally-sensitized-rats
#8
Marlène Rasschaert, Andréa Emerit, Nathalie Fretellier, Cécile Factor, Philippe Robert, Jean-Marc Idée, Claire Corot
OBJECTIVES: This preclinical study was designed to compare gadolinium (Gd) brain uptake after repeated injections of a macrocyclic Gd-based contrast agent (GBCA) (gadoterate meglumine) or 2 linear GBCAs (L-GBCAs) (gadobenate dimeglumine or gadodiamide) on a translational model of moderate renal impairment in rats. METHODS: The study was carried out in subtotally nephrectomized rats. Animals received 4 intravenous injections per week of GBCA (gadoterate meglumine, gadobenate dimeglumine, or gadodiamide) for 5 weeks, resulting in a cumulative dose of 12 mmol/kg, followed by a 1-month injection-free period...
January 12, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29300175/comparison-of-arterial-input-functions-measured-from-ultra-fast-dynamic-contrast-enhanced-mri-and-dynamic-contrast-enhanced-computed-tomography-in-prostate-cancer-patients
#9
Shiyang Wang, Zhengfeng Lu, Xiaobing Fan, Milica Medved, Xia Jiang, Steffen Sammet, Ambereen Yousuf, Federico Pineda, Aytekin Oto, Gregory S Karczmar
The purpose of this study was to evaluate the accuracy of arterial input functions (AIFs) measured from dynamic contrast enhanced (DCE) MRI following a low dose of contrast media injection. The AIFs measured from DCE computed tomography (CT) were used as 'gold standard'. A total of twenty patients received CT and MRI scans on the same day. Patients received 120 ml Iohexol in DCE-CT and a low dose of (0.015 mM kg-1 ) of gadobenate dimeglumine in DCE-MRI. The AIFs were measured in the iliac artery and normalized to the CT and MRI contrast agent doses...
January 30, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29297607/signal-enhancement-ratio-imaging-of-the-lung-parenchyma-with-ultra-fast-steady-state-free-precession-mri-at-1-5t
#10
Orso Pusterla, Gregor Sommer, Francesco Santini, Mark Wiese, Didier Lardinois, Michael Tamm, Jens Bremerich, Grzegorz Bauman, Oliver Bieri
BACKGROUND: Lung perfusion MRI after i.v. gadolinium (Gd) contrast administration is commonly based on spoiled gradient-echo acquisitions, such as volume-interpolated breath-hold examinations (VIBE), suffering from low signal-to-noise in the parenchyma. PURPOSE: To investigate the lung signal enhancement ratio (SER) with ultra-fast steady-state free precession (ufSSFP) after Gd-administration. STUDY TYPE: Retrospective. SUBJECTS: Ten subjects with healthy lungs; nine patients with pulmonary diseases (chronic obstructive pulmonary disease [COPD], lung cancer, pulmonary fibrosis, lung contusion)...
January 3, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29278694/non-clinical-assessment-of-safety-and-gadolinium-deposition-after-cumulative-administration-of-gadobenate-dimeglumine-multihance-%C3%A2-to-neonatal-and-juvenile-rats
#11
Simona Bussi, Laure Penard, Roberta Bonafè, Catherine Botteron, Roberto Celeste, Alessandra Coppo, Roberta Queliti, Miles A Kirchin, Fabio Tedoldi, Federico Maisano
To determine the impact of single and cumulative doses of MultiHance on toxicity, pharmacokinetics, tissue gadolinium presence, behavior and neurological function in juvenile rats. Juvenile male and female rats received either physiological saline or MultiHance at 0.6, 1.25 or 2.5 mmol/kg bodyweight. Animals received either single or six consecutive MultiHance administrations and were sacrificed the day after the last administration or after a 60-day treatment-free period. Animals were assessed for behavior, cognitive function, grip strength, gait, pupillary reflex, and auditory reflex, as well as for physical development, sexual maturation and histopathology...
February 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29221964/inflammatory-hepatic-adenomas-characterization-with-hepatobiliary-mri-contrast-agents
#12
James F Glockner, Christine U Lee, Taofic Mounajjed
PURPOSE: To characterize the MRI appearance of inflammatory hepatic adenomas using hepatobiliary contrast agents. MATERIALS AND METHODS: MRI was performed using hepatobiliary contrast agents (3 with gadobenate dimeglumine and 24 with gadoxetic acid) in 27 patients with immunohistochemistry-confirmed diagnosis of inflammatory hepatic adenoma. The appearance of the lesions on T2 and diffusion-weighted images, pre-gadolinium T1-weighted images, dynamic post-gadolinium images, and hepatobiliary phase images was assessed...
April 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29146718/deep-brain-nuclei-t1-shortening-after-gadobenate-dimeglumine-in-children-influence-of-radiation-and-chemotherapy
#13
S Kinner, T B Schubert, R J Bruce, S L Rebsamen, C A Diamond, S B Reeder, H A Rowley
BACKGROUND AND PURPOSE: Intrinsic T1-hyperintense signal has recently been reported in the deep gray nuclei on brain MR imaging after multiple doses of gadolinium-based contrast agents. Most reports have included adult patients and excluded those undergoing radiation or chemotherapy. We investigated whether T1 shortening is also observed in children and tried to determine whether radiochemotherapy is a risk factor for this phenomenon. MATERIALS AND METHODS: In this single-center retrospective study, we reviewed clinical charts and images of all patients 18 years of age or younger with ≥4 gadobenate dimeglumine-enhanced MRIs for 6 years...
January 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28988883/t1-weighted-parenchyma-attenuated-inversion-recovery-a-novel-sequence-that-improves-contrast-ratio-of-enhancing-brain-lesions
#14
A Batouli, E Kanal, A Gholamrezanezhad, M Spearman
PURPOSE: The purpose of this study was to develop and test a parenchyma attenuated T1-weighted inversion recovery MR sequence (PAIR) that increases the contrast between enhancing and non-enhancing tissues in the brain and to compare the contrast ratio of enhancing brain tumors on this sequence compared to spin echo magnetization transfer (SEMT). PATIENTS AND METHODS: PAIR sequence parameters were developed to reduce signal from gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) in a healthy adult volunteer...
January 2018: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28987703/early-myocardial-gadolinium-enhancement-in-patients-with-myocarditis-validation-of-lake-louise-consensus-criteria-using-a-single-bolus-of-0-1mmol-kg-of-a-high-relaxivity-gadolinium-based-contrast-agent
#15
Nicola Galea, Marco Francone, Andrea Fiorelli, Vincenzo Noce, Elisa Giannetta, Cristina Chimenti, Andrea Frustaci, Carlo Catalano, Iacopo Carbone
OBJECTIVES: Global early gadolinium enhancement (EGE) is an accepted cardiac magnetic resonance (CMR) criterion for diagnosis of myocarditis. However, recommended enhancement thresholds are based specifically on standard-relaxivity Gd-chelates. We evaluated the performance of a high relaxivity MR contrast agent for detection of myocardial hyperemia in patients referred for endomyocardial biopsy (EMB). METHODS: We retrospectively enrolled 54 patients (mean age: 44...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28895422/the-value-of-gd-bopta-enhanced-mris-and-dwi-in-the-diagnosis-of-intrahepatic-mass-forming-cholangiocarcinoma
#16
C C Xu, Y F Tang, X Z Ruan, Q L Huang, L Sun, J Li
The aim of this study is to explore the value of unenhanced magnetic resonance imaging (MRI), gadobenate dimeglumine injection (Gd-BOPTA)-enhanced MRI and diffusion-weighted imaging (DWI) in the diagnosis of intrahepatic mass-forming cholangiocarcinoma (IMCC). Totally 59 IMCC patients who underwent Gd-BOPTA-enhanced MRIs were recruited. The time-signal intensity curves and lesion periphery enhancement rates of the IMCC and liver parenchyma was drawn using apparent diffusion coefficient (ADC) values. The Gd-BOPTA-enhanced MRI showed that the peripheries of 30 lesions in the arterial phase exhibited irregular ring enhancement...
September 12, 2017: Neoplasma
https://www.readbyqxmd.com/read/28770484/high-resolution-mr-lymphangiography-for-planning-lymphaticovenous-anastomosis-treatment-a-single-centre-experience
#17
Maria Antonietta Mazzei, Francesco Gentili, Francesco Giuseppe Mazzei, Paolo Gennaro, Duccio Guerrieri, Andrea Nigri, Guido Gabriele, Elisabetta Weber, Alfonso Fausto, Giuseppe Botta, Luca Volterrani
PURPOSE: This article illustrates the feasibility of MR lymphangiography (MRL) for imaging lymphatic vessels in patients with lymphedema, its accuracy in distinguishing lymphatic vessels from veins, and its utility for planning Lymphaticovenous anastomosis (LVA) treatment. MATERIALS AND METHODS: We prospectively enrolled 30 patients (24 women, range 18-70, 17 cases of lower limb lymphedema, 6 cases of primary lymphedema). All the patients underwent MRL, using a 1...
December 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28731375/notice-of-withdrawal-no-incidence-of-nephrogenic-systemic-fibrosis-after-gadobenate-dimeglumine-administration-in-patients-undergoing-dialysis-or-those-with-severe-chronic-kidney-disease
#18
Diego R Martin, Bobby Kalb, Ankush Mittal, Khalil Salman, Srinivasan Vedantham, Pardeep K Mittal
The authors have requested to withdraw this manuscript from publication because the study was not conducted in full accordance with the relevant institutional IRB protocol.© RSNA, 2018.
January 2018: Radiology
https://www.readbyqxmd.com/read/28708734/t2-correction-in-dynamic-contrast-enhanced-magnetic-resonance-imaging-of-glioblastoma-from-a-half-dose-of-high-relaxivity-contrast-agent
#19
Silvano Filice, Girolamo Crisi, Gunter Erb
OBJECTIVE: The aim of this study was to evaluate the arterial input function (AIF) and tissue enhancement time curve (tissue function [TF]) obtained after the administration of a half-dose gadobenate dimeglumine (0.05-mmol/kg body weight [bw]) compared with a full dose (0.1-mmol/kg bw) of a standard-relaxivity contrast agent. METHODS: We enrolled 40 adult patients with glioblastoma in an interindividual comparative study. Patients were randomized to 1 of the 2 study arms: 20 patients received 0...
November 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28683109/18-f-fdg-pet-mr-imaging-in-patients-with-suspected-liver-lesions-value-of-liver-specific-contrast-agent-gadobenate-dimeglumine
#20
Julian Kirchner, Lino M Sawicki, Cornelius Deuschl, Johannes Grüneisen, Karsten Beiderwellen, Thomas C Lauenstein, Ken Herrmann, Michael Forsting, Philipp Heusch, Lale Umutlu
OBJECTIVES: To evaluate the added value of the application of the liver-specific contrast phase of Gadobenate dimeglumine (Gd-BOPTA) for detection and characterization of liver lesions in 18F-FDG PET/MRI. METHODS: 41 patients with histologically confirmed solid tumors and known / suspected liver metastases or not classifiable lesions in 18F-FDG PET/CT were included in this study. All patients underwent a subsequent Gd-BOPTA enhanced 18F-FDG PET/MRI examination. MRI without liver-specific contrast phase (MRI1), MRI with liver-specific contrast phase (MRI2), 18F-FDG PET/MRI without liver-specific contrast phase (PET/MRI1) and with liver-specific contrast phase (PET/MRI2) were separately evaluated for suspect lesions regarding lesion dignity, characterization, conspicuity and confidence...
2017: PloS One
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