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Gadoteridol

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https://www.readbyqxmd.com/read/29106751/fast-na-k-pump-driven-steady-state-transcytolemmal-water-exchange-in-neuronal-tissue-a-study-of-rat-brain-cortical-cultures
#1
Ruiliang Bai, Charles S Springer, Dietmar Plenz, Peter J Basser
PURPOSE: Water homeostasis and transport play important roles in brain function (e.g., ion homeostasis, neuronal excitability, cell volume regulation, etc.). However, specific mechanisms of water transport across cell membranes in neuronal tissue have not been completely elaborated. METHODS: The kinetics of transcytolemmal water exchange were measured in neuronal tissue using simultaneous, real-time fluorescence and nuclear magnetic resonance (NMR) measurements of perfused, active brain organotypic cortical cultures...
November 6, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28972742/ultrasmall-paramagnetic-iron-oxide-nanoprobe-targeting-epidermal-growth-factor-receptor-for-in-vivo-magnetic-resonance-imaging-of-hepatocellular-carcinoma
#2
Yan Chen, Quan Zhou, Xue Li, Fa Wang, Kevin Heist, Rork Kuick, Scott R Owens, Thomas D Wang
Hepatocellular carcinoma (HCC) is a common worldwide cancer that is rising rapidly in incidence. MRI is a powerful noninvasive imaging modality for HCC detection, but lack of specific contrast agents limits visualization of small tumors. EGFR is frequently overexpressed in HCC and is a promising target. Peptides have fast binding kinetics, short circulatory half-life, low imaging background, high vascular permeability, and enhanced tissue diffusion for deep tumor penetration. We demonstrate a peptide specific for EGFR labeled with an ultrasmall paramagnetic iron oxide (UPIO) nanoparticle with 3...
October 20, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28966303/appearance-of-the-organum-vasculosum-of-the-lamina-terminalis-on-contrast-enhanced-mr-imaging
#3
Shinji Naganawa, Toshiaki Taoka, Hisashi Kawai, Masahiro Yamazaki, Kojiro Suzuki
PURPOSE: Circumventricular organs (CVOs) lack a blood brain barrier and are also called "brain windows". Among CVOs, the organum vasculosum of the lamina terminalis (OVLT) is an osmotic regulator involved in the release of vasopressin. In a previous study of healthy subjects, it was reported that contrast enhancement in the OVLT can be recognized in only 34% of 3 Tesla thin slice contrast-enhanced T1-weighted images. The purpose of this study was to evaluate the leakage of gadolinium contrast from the OVLT in healthy subjects using heavily T2-weighted three dimensional-fluid attenuated inversion recovery (3D-FLAIR) (HF) imaging...
September 29, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28894937/gadoxetate-disodium-induced-tachypnoea-and-the-effect-of-dilution-method-a-proof-of-concept-study-in-mice
#4
Hiroyuki Akai, Koichiro Yasaka, Masanori Nojima, Akira Kunimatsu, Yusuke Inoue, Osamu Abe, Kuni Ohtomo, Shigeru Kiryu
OBJECTIVES: To directly investigate the rapid respiratory effect of gadoxetate disodium in an experimental study using mice. METHODS: After confirming the steady respiratory state under general anaesthesia, eight mice were injected with all test agents in the following order: phosphate-buffered saline (A, control group), 1.25 mmol/kg of gadoteridol (B) or gadopentetate dimeglumine (C), or 0.31 mmol/kg of gadoxetate disodium (D, E). The experimenter was not blinded to the agents...
September 11, 2017: European Radiology
https://www.readbyqxmd.com/read/28873047/gadolinium-retention-in-the-rat-brain-assessment-of-the-amounts-of-insoluble-gadolinium-containing-species-and-intact-gadolinium-complexes-after-repeated-administration-of-gadolinium-based-contrast-agents
#5
Eliana Gianolio, Paola Bardini, Francesca Arena, Rachele Stefania, Enza Di Gregorio, Rebecca Iani, Silvio Aime
Purpose To evaluate the speciation of gadolinium-containing species after multiple administrations of the gadolinium-based contrast agents (GBCAs) gadodiamide and gadoteridol and to quantify the amount of intact gadolinium complexes and insoluble gadolinium-containing species. Materials and Methods A total dose of 13.2 mmol per kilogram of body weight of each GBCA was administered in healthy Wistar rats over a period of 8 weeks. Three days after the final administration, rats were sacrificed, and the brains were excised and divided into three portions...
December 2017: Radiology
https://www.readbyqxmd.com/read/28873045/gadolinium-chelate-safety-in-pregnancy-barely-detectable-gadolinium-levels-in-the-juvenile-nonhuman-primate-after-in-utero-exposure
#6
Joao Prola-Netto, Mark Woods, Victoria H J Roberts, Elinor L Sullivan, Christina Ann Miller, Antonio E Frias, Karen Y Oh
Purpose To determine whether gadolinium remains in juvenile nonhuman primate tissue after maternal exposure to intravenous gadoteridol during pregnancy. Materials and Methods Gravid rhesus macaques and their offspring (n = 10) were maintained, as approved by the institutional animal care and utilization committee. They were prospectively studied as part of a pre-existing ongoing research protocol to evaluate the effects of maternal malnutrition on placental and fetal development. On gestational days 85 and 135, they underwent placental magnetic resonance imaging after intravenous gadoteridol administration...
September 4, 2017: Radiology
https://www.readbyqxmd.com/read/28730643/differences-in-gadolinium-retention-after-repeated-injections-of-macrocyclic-mr-contrast-agents-to-rats
#7
Simona Bussi, Alessandra Coppo, Catherine Botteron, Valérie Fraimbault, Antonello Fanizzi, Elisa De Laurentiis, Sonia Colombo Serra, Miles A Kirchin, Fabio Tedoldi, Federico Maisano
PURPOSE: To compare the levels of gadolinium in the blood, cerebrum, cerebellum, liver, femur, kidneys, and skin after multiple exposure of rats to the macrocyclic gadolinium-based contrast agents (GBCAs) gadoterate, gadobutrol, and gadoteridol. MATERIALS AND METHODS: Fifty male Wistar Han rats were randomized to three exposure groups (n = 15 per group) and one control group (n = 5). Animals in the exposure groups received a total of 20 GBCA administrations (four administrations per week for 5 consecutive weeks) at a dose of 0...
July 21, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28640695/gadolinium-brain-deposition-after-macrocyclic-gadolinium-administration-a-pediatric-case-control-study
#8
Daniel Tibussek, Christin Rademacher, Julian Caspers, Bernd Turowski, Jörg Schaper, Gerald Antoch, Dirk Klee
Purpose To determine whether signal intensity (SI) in T1 sequences as a potential indicator of gadolinium deposition increases after repeated administration of the macrocyclic gadolinium-based contrast agents (GBCAs) gadoteridol and gadoterate meglumine in a pediatric cohort. Materials and Methods This retrospective case-control study of children with brain tumors who underwent nine or more contrast material-enhanced brain magnetic resonance (MR) imaging studies from 2008 to 2015 was approved by the local ethics board...
October 2017: Radiology
https://www.readbyqxmd.com/read/28640692/comparison-of-gadolinium-concentrations-within-multiple-rat-organs-after-intravenous-administration-of-linear-versus-macrocyclic-gadolinium-chelates
#9
Robert J McDonald, Jennifer S McDonald, Daying Dai, Dana Schroeder, Mark E Jentoft, David L Murray, Ramanathan Kadirvel, Laurence J Eckel, David F Kallmes
Purpose To compare gadolinium tissue concentrations of multiple linear and macrocyclic chelates in a rat model to better understand the scope and extent of tissue deposition following multiple intravenous doses of gadolinium-based contrast agent (GBCA). Materials and Methods In this Institutional Animal Care and Use Committee-approved study, healthy rats received 20 intravenous injections of 2.5 mmol gadolinium per kilogram (gadolinium-exposed group) or saline (control group) over a 26-day period. Unenhanced T1 signal intensities of the dentate nucleus were measured from magnetic resonance (MR) images obtained prior to GBCA injection and 3 days after final injection...
November 2017: Radiology
https://www.readbyqxmd.com/read/28598900/interleaved-mapping-of-temperature-and-longitudinal-relaxation-rate-to-monitor-drug-delivery-during-magnetic-resonance-guided-high-intensity-focused-ultrasound-induced-hyperthermia
#10
Esther Kneepkens, Edwin Heijman, Jochen Keupp, Steffen Weiss, Klaas Nicolay, Holger Grüll
OBJECTIVES: Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) is a method to heat lesions noninvasively to a stable, elevated temperature and a well-suited method to induce local hyperthermia (41°C-43°C) in deep-seated tissues. Magnetic Resonance (MR) imaging provides therapy planning on anatomical images and offers temperature feedback based on near-real-time MR thermometry. Although constant acquisition of MR thermometry data is crucial to ensure prolonged hyperthermia, it limits the freedom to perform measurements of other MR parameters, which are of interest during hyperthermia treatments...
June 8, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28395970/dynamic-contrast-enhanced-mri-detects-changes-in-vascular-transport-rate-constants-following-treatment-with-thermally-sensitive-liposomal-doxorubicin
#11
Brett Z Fite, Azadeh Kheirolomoom, Josquin L Foiret, Jai W Seo, Lisa M Mahakian, Elizabeth S Ingham, Sarah M Tam, Alexander D Borowsky, Fitz-Roy E Curry, Katherine W Ferrara
Temperature-sensitive liposomal formulations of chemotherapeutics, such as doxorubicin, can achieve locally high drug concentrations within a tumor and tumor vasculature while maintaining low systemic toxicity. Further, doxorubicin delivery by temperature-sensitive liposomes can reliably cure local cancer in mouse models. Histological sections of treated tumors have detected red blood cell extravasation within tumors treated with temperature-sensitive doxorubicin and ultrasound hyperthermia. We hypothesize that the local release of drug into the tumor vasculature and resulting high drug concentration can alter vascular transport rate constants along with having direct tumoricidal effects...
June 28, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28323657/histology-and-gadolinium-distribution-in-the-rodent-brain-after-the-administration-of-cumulative-high-doses-of-linear-and-macrocyclic-gadolinium-based-contrast-agents
#12
Jessica Lohrke, Anna-Lena Frisk, Thomas Frenzel, Laura Schöckel, Martin Rosenbruch, Gregor Jost, Diana Constanze Lenhard, Martin A Sieber, Volker Nischwitz, Astrid Küppers, Hubertus Pietsch
OBJECTIVES: Retrospective studies in patients with primary brain tumors or other central nervous system pathologies as well as postmortem studies have suggested that gadolinium (Gd) deposition occurs in the dentate nucleus (DN) and globus pallidus (GP) after multiple administrations of primarily linear Gd-based contrast agents (GBCAs). However, this deposition has not been associated with any adverse effects or histopathological alterations. The aim of this preclinical study was to systematically examine differences between linear and macrocyclic GBCAs in their potential to induce changes in brain and skin histology including Gd distribution in high spatial resolution...
June 2017: Investigative Radiology
https://www.readbyqxmd.com/read/27572810/mri-cest-assessment-of-tumour-perfusion-using-x-ray-iodinated-agents-comparison-with-a-conventional-gd-based-agent
#13
COMPARATIVE STUDY
Annasofia Anemone, Lorena Consolino, Dario Livio Longo
OBJECTIVES: X-ray iodinated contrast media have been shown to generate contrast in MR images when used with the chemical exchange saturation transfer (CEST) approach. The aim of this study is to compare contrast enhancement (CE) capabilities and perfusion estimates between radiographic molecules and a Gd-based contrast agent in two tumour murine models with different vascularization patterns. METHODS: MRI-CEST and MRI-CE T1w images were acquired in murine TS/A and 4 T1 breast tumours upon sequential i...
May 2017: European Radiology
https://www.readbyqxmd.com/read/27315460/investigation-of-the-ototoxicity-of-gadoteridol-prohance-and-gadodiamide-omniscan-in-mice
#14
Hiroshi Nonoyama, Tohru Tanigawa, Rei Shibata, Hirokazu Tanaka, Nobuyuki Katahira, Yuichiro Horibe, Keiji Takemura, Kenta Murotani, Norio Ozeki, Hiromi Ueda
CONCLUSION: In the mouse, when a tympanic perforation is present, gadoteridol does not seem to cause ototoxicity. Gadodiamide may cause mild ototoxicity other than toxicity to the outer hair cells of the cochlea. OBJECTIVES: Endolymphatic hydrops have been visualized through intra-tympanic injection of gadolinium-based contrast agents (GBCAs) and three-dimensional fluid-attenuated inversion recovery (3-D FLAIR) magnetic resonance imaging. However, reports on the safety of GBCAs are limited...
November 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27303104/contrast-enhanced-magnetic-resonance-pancreatography-with-gadoteridol-by-heavily-t2-weighted-three-dimensional-fluid-attenuated-inversion-recovery-preliminary-results-in-healthy-subjects
#15
Kojiro Suzuki, Shinji Naganawa, Naohiro Furuhashi, Masahiro Yamazaki, Hiroshi Ogawa, Hisashi Kawai
The purpose of this study was to investigate the feasibility of contrast-enhanced magnetic resonance (MR) pancreatography with intravenously administered gadolinium-based contrast material (GBCM) in healthy subjects. Eight healthy male subjects (age: 29-53 years old, median: 37 years old) were enrolled. Contrast-enhanced MR pancreatography was scanned with heavily T2-weighted three-dimensional fluid-attenuated inversion recovery (hT2W-3D-FLAIR) before and after intravenous GBCM administration. Two radiologists evaluated the images, referring to three-dimensional MR pancreatography by consensus...
May 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/27297589/human-whole-blood-1-h2-o-transverse-relaxation-with-gadolinium-based-contrast-reagents-magnetic-susceptibility-and-transmembrane-water-exchange
#16
Gregory J Wilson, Charles S Springer, Sarah Bastawrous, Jeffrey H Maki
PURPOSE: To characterize transverse relaxation in oxygenated whole blood with extracellular gadolinium-based contrast reagents by experiment and simulation. METHODS: Experimental measurements of transverse (1) H2 O relaxation from oxygenated whole human blood and plasma were made at 1.5 and 3.0 Tesla. Spin-echo refocused and free-induction decays are reported for blood and plasma samples containing four different contrast reagents (gadobenate, gadoteridol, gadofosveset, and gadobutrol), each present at concentrations ranging from 1 to 18 mM (i...
May 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27212626/successful-in-vivo-mri-tracking-of-mscs-labeled-with-gadoteridol-in-a-spinal-cord-injury-experimental-model
#17
Miriam Filippi, Marina Boido, Chiara Pasquino, Francesca Garello, Cinzia Boffa, Enzo Terreno
In this study, murine Mesenchymal Stem Cells (MSCs) labeled with the clinically approved MRI agent Gadoteridol through a procedure based on the hypo-osmotic shock were successfully tracked in vivo in a murine model of Spinal Cord Injury (SCI). With respect to iso-osmotic incubations, the hypo-osmotic labeling significantly increased the Gd(3+) cellular uptake, and enhanced both the longitudinal relaxivity (r1) of the intracellular Gadoteridol and the Signal to Noise Ratio (SNR) measured on cell pellets, without altering the biological and functional profile of cells...
August 2016: Experimental Neurology
https://www.readbyqxmd.com/read/27175546/revisiting-the-pharmacokinetic-profiles-of-gadolinium-based-contrast-agents-differences-in-long-term-biodistribution-and-excretion
#18
Eric Lancelot
OBJECTIVES: Gadolinium-based contrast agents (GBCAs) have been used for years for magnetic resonance imaging examinations. Because of their rapid blood clearance, they were considered as very safe products until some of them were shown to induce nephrogenic systemic fibrosis in patients with renal failure and hypersignals on T1-weighted unenhanced brain scans of patients with normal renal function. To date, these adverse effects have been related almost exclusively to the use of low-stability linear agents, which are more prone to release free gadolinium...
November 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27149390/evaluation-of-a-tailored-injection-profile-tip-algorithm-for-uniform-contrast-enhanced-signal-intensity-profiles-in-mr-angiography
#19
Gregory J Wilson, Jeffrey H Maki
PURPOSE: To evaluate a contrast agent injection method that provides constant magnetic resonance imaging (MRI) signal intensity throughout a contrast-enhanced MR angiography acquisition. MATERIALS AND METHODS: A tailored injection profile (TIP) algorithm was developed that used the signal intensity profile from a test bolus as an impulse response function, and predicted the response to various multiphasic injection profiles. Antecubital vein injections were administered via a commercially available multiphasic power injector...
December 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27049069/the-release-of-doxorubicin-from-liposomes-monitored-by-mri-and-triggered-by-a-combination-of-us-stimuli-led-to-a-complete-tumor-regression-in-a-breast-cancer-mouse-model
#20
S Rizzitelli, P Giustetto, D Faletto, D Delli Castelli, S Aime, E Terreno
The work aimed at developing a novel MRI-based theranostic protocol for improving the anticancer efficacy of a Doxil-like liposomal formulation. The goal was achieved stimulating the intratumor release of the drug from the nanocarrier and favoring its diffusion in the lesion by the sequential application of low-intensity pulsed ultrasound. The protocol was tested on mice bearing a syngeneic breast cancer model. The combination of acoustic waves with different characteristics allowed for: i) the release of the drug and the co-encapsulated MRI agent (Gadoteridol) from the liposomes in the vessels of the tumor region, and ii) the extravasation of the released material, as well as intact liposomes, in the tumor stroma...
May 28, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
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