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https://www.readbyqxmd.com/read/29097910/analytical-interference-by-contrast-agents-in-biochemical-assays
#1
Sigrid Otnes, Niels Fogh-Andersen, Janne Rømsing, Henrik S Thomsen
Objective: To provide a clinically relevant overview of the analytical interference by contrast agents (CA) in laboratory blood test measurements. Materials and Methods: The effects of five CAs, gadobutrol, gadoterate meglumine, gadoxetate disodium, iodixanol, and iomeprol, were studied on the 29 most frequently performed biochemical assays. One-day-old plasma, serum, and whole blood were spiked with doses of each agent such that the gadolinium agents and the iodine agents reached concentrations of 0...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29050735/-inferior-myocardial-infarction-complicated-by-complete-heart-block-and-cardiac-arrest-following-a-gadolinium-injection-a-case-of-kounis-syndrome
#2
R Demoulin, R Poyet, E Capilla, M Cardinale, A V Tortat, F Pons, F-X Brocq, C Jego, G Foucault, G-R Cellarier
Kounis syndrome is an allergic acute coronary syndrome. It occurs on healthy or pathological arteries. Its complications, although often benign, can lead to cardiac arrest and death. Its triggering factors are multiple and include contrast products used in diagnostic imaging. We report the case of an 81 years old patient affected by hepatocellular carcinoma, who presented a type 2 Kounis syndrome with inferior myocardial infarction, complicated by cardiac arrest related to complete heart block following a gadoteric acid injection...
November 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/28956156/absence-of-clinical-cerebellar-syndrome-after-serial-injections-of-more-than-20-doses-of-gadoterate-a-macrocyclic-gbca-a-monocenter-retrospective-study
#3
Gaetano Perrotta, Thierry Metens, Julie Absil, Marc Lemort, Mario Manto
Sound evidence of gadolinium accumulation in brain has been recently provided after repeated administrations of linear gadolinium-based contrast agents (GBCAs), especially at the cerebellum level. Although data regarding brain accumulation of macrocyclic GBCAs are more reassuring, there is now a genuine concern ("gadolinium-phobia") about possible long-term consequences of gadolinium deposits, especially in terms of cerebellar sequelae. We, therefore, questioned about the clinical impact of serial administration of gadoterate meglumine, a macrocyclic GBCA...
November 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28952018/effects-of-serial-macrocyclic-based-contrast-materials-gadoterate-meglumine-and-gadobutrol-administrations-on-gadolinium-related-dentate-nuclei-signal-increases-in-unenhanced-t1-weighted-brain-a-retrospective-study-in-158-multiple-sclerosis-ms-patients
#4
Alessandra Splendiani, Marco Perri, Claudia Marsecano, Valentina Vellucci, Giulia Michelini, Antonio Barile, Ernesto Di Cesare
PURPOSE: To perform T1 signal intensity (SI) measurements in the dentate nuclei of adult patients with confirmed multiple sclerosis (MS) after serial administrations of the macrocyclic gadolinium-based contrast agents (GBCAs), gadoterate meglumine and gadobutrol. MATERIALS AND METHODS: This retrospective study was approved by the institutional review board and informed consent was waived. A review of our PACS database for the period from March 1, 2007 to July 31, 2016 revealed 158 confirmed MS patients who received exclusively either gadoterate meglumine (n = 81) or gadobutrol (n = 77) for diagnosis and follow-up...
September 27, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28915162/the-effect-of-perinatal-gadolinium-based-contrast-agents-on-adult-mice-behavior
#5
Miski Aghnia Khairinisa, Yusuke Takatsuru, Izuki Amano, Khongorzul Erdene, Takahito Nakajima, Satomi Kameo, Hiroshi Koyama, Yoshito Tsushima, Noriyuki Koibuchi
OBJECTIVES: The aim of this study was to examine the effects of perinatal exposure to gadolinium (Gd)-based contrast agents (GBCAs) on the behavior of adulthood offspring. MATERIALS AND METHODS: Pregnant Balb/C mice (n = 5 per group) were intravenously injected with gadoterate meglumine (Magnescope, macrocyclic GBCA), gadodiamide (Omniscan, linear GBCA), or vehicle from pregnancy day 15 to 19, corresponding to embryonic day 15 to 19 of the fetus, at 2 mmol/kg body weight per day...
September 14, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28913611/prospective-intraindividual-comparison-of-gadoterate-and-gadobutrol-for-cervical-and-intracranial-contrast-enhanced-magnetic-resonance-angiography
#6
Philip Hoelter, Stefan Lang, Marina Weibart, Manuel Schmidt, Michael F X Knott, Tobias Engelhorn, Marco Essig, Stephan Kloska, Arnd Doerfler
PURPOSE: Gadobutrol (GB) is reported to provide improved relaxivity and concentration compared to gadoterate (GT). This study was designed to intraindividually compare quantitative and qualitative enhancement characteristics of GB to GT in cervicocranial magnetic resonance angiography (MRA) of patients with cerebrovascular disease (CVD). METHODS: Patients (n = 54) with CVD underwent two identical contrast-enhanced magnetic resonance angiography (CE-MRA) examinations of the cervical and intracranial vasculature in randomized order, using GB and GT in equimolar dose...
December 2017: Neuroradiology
https://www.readbyqxmd.com/read/28906338/a-pharmacokinetics-efficacy-and-safety-study-of-gadoterate-meglumine-in-pediatric-subjects-aged-younger-than-2-years
#7
Mario Scala, Meriam Koob, Sophie de Buttet, Philippe Bourrinet, Mathieu Felices, Elzbieta Jurkiewicz
OBJECTIVES: The primary objective of this study was to investigate the pharmacokinetic profile of gadoterate meglumine in pediatric patients younger than 2 years; the secondary objectives were to document its efficacy and safety. MATERIAL AND METHODS: This was a Phase IV open-label, prospective study conducted in 9 centers (4 countries). Forty-five patients younger than 2 years with normal estimated glomerular filtration rate and scheduled to undergo routine gadolinium-enhanced magnetic resonance imaging (MRI) of any organ were included and received a single intravenous injection of gadoterate meglumine (0...
September 12, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28864020/pre-clinical-evaluation-of-a-nanoparticle-based-blood-pool-contrast-agent-for-mr-imaging-of-the-placenta
#8
Ketan B Ghaghada, Zbigniew A Starosolski, Saakshi Bhayana, Igor Stupin, Chandreshkumar V Patel, Rohan C Bhavane, Haijun Gao, Andrey Bednov, Chandrasekhar Yallampalli, Michael Belfort, Verghese George, Ananth V Annapragada
INTRODUCTION: Non-invasive 3D imaging that enables clear visualization of placental margins is of interest in the accurate diagnosis of placental pathologies. This study investigated if contrast-enhanced MRI performed using a liposomal gadolinium blood-pool contrast agent (liposomal-Gd) enables clear visualization of the placental margins and the placental-myometrial interface (retroplacental space). Non-contrast MRI and contrast-enhanced MRI using a clinically approved conventional contrast agent were used as comparators...
September 2017: Placenta
https://www.readbyqxmd.com/read/28730643/differences-in-gadolinium-retention-after-repeated-injections-of-macrocyclic-mr-contrast-agents-to-rats
#9
Simona Bussi, Alessandra Coppo, Catherine Botteron, Valérie Fraimbault, Antonello Fanizzi, Elisa De Laurentiis, Sonia Colombo Serra, Miles A Kirchin, Fabio Tedoldi, Federico Maisano
PURPOSE: To compare the levels of gadolinium in the blood, cerebrum, cerebellum, liver, femur, kidneys, and skin after multiple exposure of rats to the macrocyclic gadolinium-based contrast agents (GBCAs) gadoterate, gadobutrol, and gadoteridol. MATERIALS AND METHODS: Fifty male Wistar Han rats were randomized to three exposure groups (n = 15 per group) and one control group (n = 5). Animals in the exposure groups received a total of 20 GBCA administrations (four administrations per week for 5 consecutive weeks) at a dose of 0...
July 21, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28730467/organ-retention-of-gadolinium-in-mother-and-pup-mice-effect-of-pregnancy-and-type-of-gadolinium-based-contrast-agents
#10
Khongorzul Erdene, Takahito Nakajima, Satomi Kameo, Miski Aghnia Khairinisa, Oyunbold Lamid-Ochir, Amartuvshin Tumenjargal, Noriyuki Koibuchi, Hiroshi Koyama, Yoshito Tsushima
PURPOSE: To investigate the effect of pregnancy and type of gadolinium (Gd)-based contrast agents (GBCAs) on organ retention of Gd in mother and pup mice after maternal administration. MATERIALS AND METHODS: Gd-DTPA-BMA (gadodiamide) or Gd-DOTA (gadoterate dimeglumine) was administered (2.0 mmol/kg of maternal weight) four times to pregnant Balb/c mice from gestational day 16-19, respectively. At 28 days after birth, they were euthanized and their organs (blood, brain, liver, kidney, spleen, and bone) were removed for the measurement of Gd by inductively coupled plasma mass spectrometry...
October 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28708734/t2-correction-in-dynamic-contrast-enhanced-magnetic-resonance-imaging-of-glioblastoma-from-a-half-dose-of-high-relaxivity-contrast-agent
#11
Silvano Filice, Girolamo Crisi, Gunter Erb
OBJECTIVE: The aim of this study was to evaluate the arterial input function (AIF) and tissue enhancement time curve (tissue function [TF]) obtained after the administration of a half-dose gadobenate dimeglumine (0.05-mmol/kg body weight [bw]) compared with a full dose (0.1-mmol/kg bw) of a standard-relaxivity contrast agent. METHODS: We enrolled 40 adult patients with glioblastoma in an interindividual comparative study. Patients were randomized to 1 of the 2 study arms: 20 patients received 0...
November 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28663267/comparison-of-gadoterate-meglumine-and-gadobutrol-in-the-mri-diagnosis-of-primary-brain-tumors-a-double-blind-randomized-controlled-intraindividual-crossover-study-the-remind-study
#12
K R Maravilla, D San-Juan, S J Kim, G Elizondo-Riojas, J R Fink, W Escobar, A Bag, D R Roberts, J Hao, C Pitrou, A J Tsiouris, E Herskovits, J B Fiebach
BACKGROUND AND PURPOSE: Effective management of patients with brain tumors depends on accurate detection and characterization of lesions. This study aimed to demonstrate the noninferiority of gadoterate meglumine versus gadobutrol for overall visualization and characterization of primary brain tumors. MATERIALS AND METHODS: This multicenter, double-blind, randomized, controlled intraindividual, crossover, noninferiority study included 279 patients. Both contrast agents (dose = 0...
September 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28645678/endolymphatic-hydrops-imaging-differential-diagnosis-in-patients-with-meniere-disease-symptoms
#13
A Attyé, M Eliezer, A Galloux, J Pietras, I Tropres, S Schmerber, G Dumas, A Krainik
PURPOSE: The goal of this retrospective study was to investigate the differential diagnosis of endolymphatic hydrops in patients with Meniere's disease (MD) symptoms by using magnetic resonance imaging (MRI) with intravenous injection of gadolinium chelate and delayed acquisition. MATERIAL AND METHOD: Two hundred patients (133 women, 67 men; mean age=67.2±11 ([SD] years) with unilateral MD underwent MRI at 3-T, between 4.5 and 5.5hours after intravenous administration of gadoterate meglumine at a dose of 0...
October 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28640695/gadolinium-brain-deposition-after-macrocyclic-gadolinium-administration-a-pediatric-case-control-study
#14
Daniel Tibussek, Christin Rademacher, Julian Caspers, Bernd Turowski, Jörg Schaper, Gerald Antoch, Dirk Klee
Purpose To determine whether signal intensity (SI) in T1 sequences as a potential indicator of gadolinium deposition increases after repeated administration of the macrocyclic gadolinium-based contrast agents (GBCAs) gadoteridol and gadoterate meglumine in a pediatric cohort. Materials and Methods This retrospective case-control study of children with brain tumors who underwent nine or more contrast material-enhanced brain magnetic resonance (MR) imaging studies from 2008 to 2015 was approved by the local ethics board...
October 2017: Radiology
https://www.readbyqxmd.com/read/28623562/physical-rupture-of-the-xylem-in-developing-sweet-cherry-fruit-causes-progressive-decline-in-xylem-sap-inflow-rate
#15
Eckhard Grimm, Daniel Pflugfelder, Dagmar van Dusschoten, Andreas Winkler, Moritz Knoche
Xylem flow is progressively shut down during maturation beginning with minor veins at the stylar end and progressing to major veins and finally to bundles at the stem end. This study investigates the functionality of the xylem vascular system in developing sweet cherry fruit (Prunus avium L.). The tracers acid fuchsin and gadoteric acid were fed to the pedicel of detached fruit. The tracer distribution was studied using light microscopy and magnetic resonance imaging. The vasculature of the sweet cherry comprises five major bundles...
June 16, 2017: Planta
https://www.readbyqxmd.com/read/28570419/ultra-high-field-9-4-t-mri-analysis-of-contrast-agent-transport-across-the-blood-perilymph-barrier-and-intrastrial-fluid-blood-barrier-in-the-mouse-inner-ear
#16
S Allen Counter, Sahar Nikkhou-Aski, Peter Damberg, Cecilia Engmér Berglin, Göran Laurell
HYPOTHESIS: Effective paramagnetic contrast agent for the penetration of the perilymphatic spaces of the scala tympani, scala vestibuli, and scala media of the mouse inner ear can be determined using intravenous injection of various gadolinium (Gd) complexes and ultra-high-field magnetic resonance imaging (MRI) at 9.4 Tesla. BACKGROUND: A number of contrast agents have been explored in experimental high-field MRI to determine the most effective Gd complex for ideal signal-to-noise ratio and maximal visualization of the in vivo mammalian inner ear in analyzing the temporal and spatial parameters involved in drug penetration of the blood-perilymph barrier and intrastrial fluid-blood barrier in the mouse model using MRI...
August 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28556691/t1-weighted-dynamic-contrast-enhanced-brain-magnetic-resonance-imaging-a-preliminary-study-with-low-infusion-rate-in-pediatric-patients
#17
Bruno-Bernard Rochetams, Bénédicte Marechal, Jean-Philippe Cottier, Kathleen Gaillot, Catherine Sembely-Taveau, Dominique Sirinelli, Baptiste Morel
Background The aim of this preliminary study is to evaluate the results of T1-weighted dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in pediatric patients at 1.5T, with a low peripheral intravenous gadoteric acid injection rate of 1 ml/s. Materials and methods Children with neurological symptoms were examined prospectively with conventional MRI and T1-weighted DCE MRI. An magnetic resonance perfusion analysis method was used to obtain time-concentration curves (persistent pattern, type-I; plateau pattern, type-II; washout pattern, type-III) and to calculate pharmacokinetic parameters...
October 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28526896/signal-intensity-at-unenhanced-t1-weighted-magnetic-resonance-in-the-globus-pallidus-and-dentate-nucleus-after-serial-administrations-of-a-macrocyclic-gadolinium-based-contrast-agent-in-children
#18
Maria Camilla Rossi Espagnet, Bruno Bernardi, Luca Pasquini, Lorenzo Figà-Talamanca, Paolo Tomà, Antonio Napolitano
BACKGROUND: Few studies have been conducted on the relations between T1-weighted signal intensity changes in the pediatric brain following gadolinium-based contrast agent (GBCA) exposure. OBJECTIVE: The purpose of this study is to investigate the effect of multiple administrations of a macrocyclic GBCA on signal intensity in the globus pallidus and dentate nucleus of the pediatric brain on unenhanced T1-weighted MR images. MATERIALS AND METHODS: This retrospective study included 50 patients, mean age: 8 years (standard deviation: 4...
September 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28444761/photon-counting-ct-for-simultaneous-imaging-of-multiple-contrast-agents-in-the-abdomen-an-in-vivo-study
#19
Rolf Symons, Bernhard Krauss, Pooyan Sahbaee, Tyler E Cork, Manu N Lakshmanan, David A Bluemke, Amir Pourmorteza
PURPOSE: To demonstrate the feasibility of spectral imaging using photon-counting detector (PCD) x-ray computed tomography (CT) for simultaneous material decomposition of three contrast agents in vivo in a large animal model. METHODS: This Institutional Animal Care and Use Committee-approved study used a canine model. Bismuth subsalicylate was administered orally 24-72 h before imaging. PCD CT was performed during intravenous administration of 40-60 ml gadoterate meglumine; 3...
October 2017: Medical Physics
https://www.readbyqxmd.com/read/28382626/use-of-radiocontrast-agents-in-ckd-and-esrd
#20
Jehan Z Bahrainwala, Amanda K Leonberg-Yoo, Michael R Rudnick
Contrast exposure in a population with chronic kidney disease (CKD) requires additional consideration given the risk of contrast-induced nephropathy (CIN) after exposure to iodinated contrast as well as systemic injury with exposure to gadolinium-based contrast agents (GBCA). Strategies to avoid CIN, and manage patients after exposure, including extracorporeal removal of contrast media, may differ among an advanced CKD population as compared to a general population. There is strong evidence to support the use of isotonic volume expansion and the lowest dose of low-osmolar or iso-osmolar contrast media possible to decrease CIN...
July 2017: Seminars in Dialysis
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