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https://www.readbyqxmd.com/read/28144867/removal-of-gadolinium-based-contrast-agents-adsorption-on-activated-carbon
#1
María P Elizalde-González, Esmeralda García-Díaz, Mario González-Perea, Jürgen Mattusch
Three carbon samples were employed in this work, including commercial (1690 m(2) g(-1)), activated carbon prepared from guava seeds (637 m(2) g(-1)), and activated carbon prepared from avocado kernel (1068 m(2) g(-1)), to study the adsorption of the following gadolinium-based contrast agents (GBCAs): gadoterate meglumine Dotarem®, gadopentetate dimeglumine Magnevist®, and gadoxetate disodium Primovist®. The activation conditions with H3PO4 were optimized using a Taguchi methodology to obtain mesoporous materials...
January 31, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28141810/validation-of-blood-volume-fraction-quantification-with-3d-gradient-echo-dynamic-contrast-enhanced-magnetic-resonance-imaging-in-porcine-skeletal-muscle
#2
Stefan Hindel, Anika Söhner, Marc Maaß, Wolfgang Sauerwein, Dorothe Möllmann, Hideo Andreas Baba, Martin Kramer, Lutz Lüdemann
The purpose of this study was to assess the accuracy of fractional blood volume (vb) estimates in low-perfused and low-vascularized tissue using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). The results of different MRI methods were compared with histology to evaluate the accuracy of these methods under clinical conditions. vb was estimated by DCE-MRI using a 3D gradient echo sequence with k-space undersampling in five muscle groups in the hind leg of 9 female pigs. Two gadolinium-based contrast agents (CA) were used: a rapidly extravasating, extracellular, gadolinium-based, low-molecular-weight contrast agent (LMCA, gadoterate meglumine) and an extracellular, gadolinium-based, albumin-binding, slowly extravasating blood pool contrast agent (BPCA, gadofosveset trisodium)...
2017: PloS One
https://www.readbyqxmd.com/read/28125438/quantification-and-assessment-of-the-chemical-form-of-residual-gadolinium-in-the-brain-after-repeated-administration-of-gadolinium-based-contrast-agents-comparative-study-in-rats
#3
Thomas Frenzel, Chirag Apte, Gregor Jost, Laura Schöckel, Jessica Lohrke, Hubertus Pietsch
OBJECTIVE: Multiple clinical and preclinical studies have reported a signal intensity increase and the presence of gadolinium (Gd) in the brain after repeated administration of Gd-based contrast agents (GBCAs). This bioanalytical study in rat brain tissue was initiated to investigate whether the residual Gd is present as intact GBCA or in other chemical forms by using tissue fractionation and chromatography. MATERIALS AND METHODS: Rats were divided randomly in 6 groups of 10 animals each...
January 25, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28047012/we-fg-207b-01-best-in-physics-imaging-abdominal-ct-with-three-k-edge-contrast-materials-using-a-whole-body-photon-counting-scanner-initial-results-of-a-large-animal-experiment
#4
M Lakshmanan, R Symons, T Cork, C Davies-Venn, K Rice, A Malayeri, V Sandfort, D Bluemke, A Pourmorteza
PURPOSE: To demonstrate the feasibility of in vivo three-material decomposition techniques using photon-counting CT (PCCT) with possible advantage of resolving arterial and venous flow of an organ simultaneously. METHODS: Abdominal PCCT scans were acquired using a prototype whole-body PCCT with four energy thresholds (25/50/75/90keV) in a canine. Bismuth subsalicylate (60 mg) was administered orally one day prior to scanning. Immediately prior to CT scan, gadoteric acid (60 ml, Dotarem, Guerbet) was intravenously injected, followed in ten minutes by a 20mL injection of iodinated contrast (iopamidol 370 mg/mL, Bracco)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27977466/extremely-small-pseudoparamagnetic-iron-oxide-nanoparticle-as-a-novel-blood-pool-t1-magnetic-resonance-contrast-agent-for-3-t-whole-heart-coronary-angiography-in-canines-comparison-with-gadoterate-meglumine
#5
Eun-Ah Park, Whal Lee, Young Ho So, Yun-Sang Lee, Bong-Sik Jeon, Kyu Sung Choi, Eung-Gyu Kim, Wan-Jae Myeong
OBJECTIVE: The aim of this study was to evaluate an extremely small pseudoparamagnetic iron oxide nanoparticle (ESPIO), KEG3, as a potential blood pool agent in 3 T coronary magnetic resonance angiography (MRA) in canine models and compare its efficacy to that of a gadolinium-based contrast agent. MATERIALS AND METHODS: Nine mongrel dogs were subjected to whole-heart coronary MRA in 2 separate sessions at 7-day intervals with a 3 T scanner using the FLASH sequence with either gadoterate meglumine (Gd-DOTA) or the ESPIO (KEG3)...
February 2017: Investigative Radiology
https://www.readbyqxmd.com/read/27925871/no-signal-intensity-increase-in-the-dentate-nucleus-on-unenhanced-t1-weighted-mr-images-after-more-than-20-serial-injections-of-macrocyclic-gadolinium-based-contrast-agents
#6
Alexander Radbruch, Robert Haase, Pascal J Kieslich, Lukas D Weberling, Philipp Kickingereder, Wolfgang Wick, Heinz-Peter Schlemmer, Martin Bendszus
Purpose To determine the effect of more than 20 serial injections of macrocyclic gadolinium-based contrast agents (GBCAs) on the signal intensity (SI) of the dentate nucleus (DN) on unenhanced T1-weighted magnetic resonance (MR) images. Materials and Methods In this retrospective, institutional review board-approved study, 33 patients who underwent at least 20 consecutive MR imaging examinations (plus an additional MR imaging for reference) with the exclusive use of macrocyclic GBCAs gadoterate meglumine and gadobutrol were analyzed...
March 2017: Radiology
https://www.readbyqxmd.com/read/27842678/diagnostic-efficacy-and-safety-of-gadoteric-acid-mr-mammography-in-1537-patients
#7
Tim Seithe, Joachim Braun, Michael Wolf, Janis Vahldiek, Dajana Wolny, Jonas Auer, Joanna Pociej, Oliver Heine, Bernd Hamm, Maximilian de Bucourt
OBJECTIVES: To perform a large-scale multicenter post-marketing surveillance study for analyzing diagnostic effectiveness and safety of intravenous (IV) gadoteric acid (Dotarem(®)) in magnetic resonance (MR) mammography under daily practice conditions. MATERIALS AND METHODS: Patients underwent high-resolution MR mammography with gadoteric acid in 15 German centers. Radiologists used a standardized questionnaire to report data including patient demographics and medical history, characteristics of MR examination and results in terms of diagnosis and safety for the patient...
December 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27805440/quantitative-analysis-of-brain-perfusion-in-healthy-dogs-by-means-of-magnetic-resonance-imaging
#8
Antje Hartmann, Agnes Driesen, Ines E Lautenschläger, Volkher B Scholz, Martin J Schmidt
OBJECTIVE To determine values of perfusion parameters determined via MRI in the brains of healthy dogs. ANIMALS 10 healthy adult Beagles. PROCEDURES Each dog was anesthetized for MRI examination of the brain, including standard sequences and a perfusion-weighted sequence. Gadoteric acid (0.2 mmol/kg) was injected IV at a rate of 5 mL/s. A dedicated workstation was used to measure the times from contrast medium injection to arrival at an ROI (TO) and peak contrast enhancement (TTP), mean contrast medium transport time (MTT), and cerebral blood flow (CBF) in the caudate nucleus, thalamus, piriform lobe, hippocampus, semioval center, and temporal cerebral cortex...
November 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27726239/observational-study-on-the-safety-profile-of-gadoterate-meglumine-in-35-499-patients-the-secure-study
#9
Philippe Soyer, Anthony Dohan, Deepak Patkar, Andreas Gottschalk
PURPOSE: To investigate the safety of gadoterate meglumine and identify the incidence of nephrogenic systemic fibrosis (NSF). MATERIALS AND METHODS: An international prospective observational study was conducted from November 2008 to June 2013. A total of 35,499 adults and children who were scheduled to undergo contrast-enhanced MRI using gadoterate meglumine were analyzed (female, 53.1%; mean age: 49.5 years; range: 0-98 years). At least 3-month follow-up was planned for patients with an estimated creatinine clearance or glomerular filtration rate <60 mL/min (/1...
October 11, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27684794/lack-of-increased-signal-intensity-in-the-dentate-nucleus-after-repeated-administration-of-a-macrocyclic-contrast-agent-in-multiple-sclerosis-an-observational-study
#10
Philipp Eisele, Angelika Alonso, Kristina Szabo, Anne Ebert, Melissa Ong, Stefan O Schoenberg, Achim Gass
Recently, several studies reported increased signal intensity (SI) in the dentate nucleus (DN) after repeated application of gadolinium-based contrast agents (GBCAs), suggesting a deposition of gadolinium in this location. Patients with relapsing-remitting multiple sclerosis (RRMS) frequently show increased permeability of the blood-brain barrier as part of the inflammatory process in the brain parenchyma, which theoretically might increase the risk of gadolinium deposition. In this retrospective study, we investigated a possible increasing SI in the DN after repeated administrations of the macrocyclic contrast agent gadoterate meglumine...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27649101/delayed-gadolinium-enhanced-mr-imaging-of-cartilage-a-comparative-analysis-of-different-gadolinium-based-contrast-agents-in-an-ex-vivo-porcine-model
#11
Yusuhn Kang, Ja-Young Choi, Hye Jin Yoo, Sung Hwan Hong, Heung Sik Kang
Purpose To compare the delayed gadolinium-enhanced magnetic resonance (MR) imaging of cartilage (dGEMRIC) indexes acquired with different gadolinium-based contrast agents (GBCAs), with emphasis on the difference in electrical charge, and to evaluate the feasibility of the use of GBCAs other than gadopentetate dimeglumine with a double negative charge (Gd-DTPA(2-)) as alternatives at dGEMRIC. Materials and Methods Intact porcine patellae (n = 44) were divided into four groups according to GBCA used: Gd-DTPA(2-), double negative gadobenate dimeglumine (Gd-BOPTA(2-)), single negative gadoterate meglumine (Gd-DOTA(-)), and nonionic gadobutrol (Gd-DT-DO3A)...
March 2017: Radiology
https://www.readbyqxmd.com/read/27647272/assessment-of-dce-mri-parameters-for-brain-tumors-through-implementation-of-physiologically-based-pharmacokinetic-model-approaches-for-gd-dota
#12
Marios Spanakis, Eleftherios Kontopodis, Sophie Van Cauter, Vangelis Sakkalis, Kostas Marias
Dynamic-contrast enhanced magnetic resonance imaging (DCE-MRI) is used for detailed characterization of pathology of lesions sites, such as brain tumors, by quantitative analysis of tracer's data through the use of pharmacokinetic (PK) models. A key component for PK models in DCE-MRI is the estimation of the concentration-time profile of the tracer in a nearby vessel, referred as Arterial Input Function (AIF). The aim of this work was to assess through full body physiologically-based pharmacokinetic (PBPK) model approaches the PK profile of gadoteric acid (Gd-DOTA) and explore potential application for parameter estimation in DCE-MRI based on PBPK-derived AIFs...
October 2016: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/27509544/intravenous-gadoxetate-disodium-administration-reduces-breath-holding-capacity-in-the-hepatic-arterial-phase-a-multi-center-randomized-placebo-controlled-trial
#13
Taylor R McClellan, Utaroh Motosugi, Michael S Middleton, Brian C Allen, Tracy A Jaffe, Chad M Miller, Scott B Reeder, Claude B Sirlin, Mustafa R Bashir
Purpose To determine, in a multicenter double-blinded placebo-controlled trial, whether maximal hepatic arterial phase breath-holding duration is affected by gadoxetate disodium administration. Materials and Methods Institutional review board approval was obtained for this prospective multi-institutional HIPAA-compliant study; written informed consent was obtained from all subjects. At three sites, a total of 44 volunteers underwent a magnetic resonance (MR) imaging examination in which images were acquired before and dynamically after bolus injection of gadoxetate disodium, normal saline, and gadoterate meglumine, administered in random order in a single session...
February 2017: Radiology
https://www.readbyqxmd.com/read/27504794/adverse-reactions-to-gadoterate-meglumine-review-of-over-25-years-of-clinical-use-and-more-than-50-million-doses
#14
Eric de Kerviler, Kenneth Maravilla, Jean-François Meder, Olivier Naggara, Corinne Dubourdieu, Vincent Jullien, Pierre Desché
OBJECTIVE: The aim of this study was to evaluate the safety profile of gadoterate meglumine from clinical trials, postmarketing observational studies, and pharmacovigilance reports of adverse drug reactions (ADRs) encompassing 25 years of clinical use and over 50 million administered doses. MATERIALS AND METHODS: Assessment of the safety of gadoterate meglumine through processing and review of all safety data was collected after magnetic resonance imaging procedures...
September 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27495187/intraindividual-analysis-of-signal-intensity-changes-in-the-dentate-nucleus-after-consecutive-serial-applications-of-linear-and-macrocyclic-gadolinium-based-contrast-agents
#15
Alexander Radbruch, Lukas D Weberling, Pascal J Kieslich, Johanna Hepp, Philipp Kickingereder, Wolfgang Wick, Heinz-Peter Schlemmer, Martin Bendszus
PURPOSE: Recent studies reported an increase in the dentate nucleus (DN)-to-pons signal intensity (SI) ratio (DN-pons SI ratio) on unenhanced T1-weighted images in patients who received consecutive serial injections of linear gadolinium-based contrast agents (GBCAs). In contrast, most studies found no increase in the DN-pons SI ratio when patients were treated with consecutive serial injections of macrocyclic GBCAs. However, the potential difference between macrocyclic and linear GBCAs has never been assessed in individuals who received subsequent applications of both contrast agents...
November 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27373976/effectiveness-of-a-high-relaxivity-contrast-agent-administered-at-half-dose-in-dynamic-susceptibility-contrast-mri-of-brain-gliomas
#16
Girolamo Crisi, Silvano Filice, Gunter Erb, Francesca Bozzetti
PURPOSE: To determine whether half of the approved dose of gadobenate dimeglumine (MultiHance) is as effective as a full dose of gadoterate meglumine (Dotarem) for qualitative and quantitative cerebral blood volume (CBV) perfusion evaluation at 3T in patients with brain gliomas. MATERIALS AND METHODS: We enrolled 65 adult patients in an interindividual comparative study. Patients were randomized to one of two study arms: 33 patients received 0.1 mmol/kg body weight (bw) of gadoterate, 32 patients received 0...
July 4, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27354423/remote-zone-extracellular-volume-and-left-ventricular-remodeling-in-survivors-of-st-elevation-myocardial-infarction
#17
Jaclyn Carberry, David Carrick, Caroline Haig, Samuli M Rauhalammi, Nadeem Ahmed, Ify Mordi, Margaret McEntegart, Mark C Petrie, Hany Eteiba, Stuart Hood, Stuart Watkins, Mitchell Lindsay, Andrew Davie, Ahmed Mahrous, Ian Ford, Naveed Sattar, Paul Welsh, Aleksandra Radjenovic, Keith G Oldroyd, Colin Berry
UNLABELLED: The natural history and pathophysiological significance of tissue remodeling in the myocardial remote zone after acute ST-elevation myocardial infarction (STEMI) is incompletely understood. Extracellular volume (ECV) in myocardial regions of interest can now be measured with cardiac magnetic resonance imaging. Patients who sustained an acute STEMI were enrolled in a cohort study (BHF MR-MI [British Heart Foundation Magnetic Resonance Imaging in Acute ST-Segment Elevation Myocardial Infarction study])...
August 2016: Hypertension
https://www.readbyqxmd.com/read/27276243/hepatic-gadolinium-deposition-and-reversibility-after-contrast-agent-enhanced-mr-imaging-of-pediatric-hematopoietic-stem-cell-transplant-recipients
#18
Natalia Maximova, Massimo Gregori, Floriana Zennaro, Aurelio Sonzogni, Roberto Simeone, Davide Zanon
Purpose To determine if hepatic gadolinium deposition occurs in pediatric patients with iron overload but normal renal and hepatic function who undergo gadolinium-based contrast agent (GBCA)-enhanced magnetic resonance (MR) imaging. Materials and Methods Design and execution of this study was approved by the Ethical Committee of Institute for Research in Maternal and Child Health Burlo Garofolo of Trieste (reference no. 1105/2015). Because of the retrospective nature of the study, the requirement to obtain informed consent was waived...
June 8, 2016: Radiology
https://www.readbyqxmd.com/read/27175546/revisiting-the-pharmacokinetic-profiles-of-gadolinium-based-contrast-agents-differences-in-long-term-biodistribution-and-excretion
#19
Eric Lancelot
OBJECTIVES: Gadolinium-based contrast agents (GBCAs) have been used for years for magnetic resonance imaging examinations. Because of their rapid blood clearance, they were considered as very safe products until some of them were shown to induce nephrogenic systemic fibrosis in patients with renal failure and hypersignals on T1-weighted unenhanced brain scans of patients with normal renal function. To date, these adverse effects have been related almost exclusively to the use of low-stability linear agents, which are more prone to release free gadolinium...
November 2016: Investigative Radiology
https://www.readbyqxmd.com/read/26795351/differences-in-perilymphatic-space-enhancement-and-adverse-inflammatory-reaction-after-intratympanic-injection-of-two-different-gadolinium-agents-a-9-4-t-magnetic-resonance-imaging-study
#20
COMPARATIVE STUDY
Mina Park, Ho Sun Lee, Hyeonjin Kim, Seung Ha Oh, Jun Ho Lee, Myung-Whan Suh
PURPOSE: To compare the inner ear enhancement after intratympanic injection of two widely used gadolinium (Gd) agents by 9.4 T micro-magnetic resonance imaging (MRI) and to investigate the effects of Gd on the inner ear. METHODS: Twelve ears of six rats received intratympanic administration of 1/5 diluted Gd agents: gadoterate meglumine (Gd-DTPA) for the left ear and gadodiamide (Gd-DTPA-BMA) for the right ear. MRI was performed every 30 min from 1 to 4 h after administration...
March 2016: Hearing Research
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