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Gadoterate

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https://www.readbyqxmd.com/read/28283727/use-of-gadolinium-based-magnetic-resonance-imaging-contrast-agents-and-awareness-of-brain-gadolinium-deposition-among-pediatric-providers-in-north-america
#1
Leena B Mithal, Payal S Patel, Divakar Mithal, Hannah L Palac, Michael N Rozenfeld
BACKGROUND: Numerous recent articles have reported brain gadolinium deposition when using linear but not macrocyclic gadolinium-based contrast agents (GBCAs). OBJECTIVE: To determine the current landscape of gadolinium use among pediatric institutions and the knowledge base of radiologists and referring providers with regard to GBCAs and brain gadolinium deposition. MATERIALS AND METHODS: We e-mailed voluntary closed surveys to 5,390 physicians in various pediatric professional societies between January 2016 and March 2016...
March 10, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28279370/myocardial-infarct-size-by-cmr-in-clinical%C3%A2-cardioprotection-studies-insights-from-randomized-controlled-trials
#2
Heerajnarain Bulluck, Matthew Hammond-Haley, Shane Weinmann, Roberto Martinez-Macias, Derek J Hausenloy
OBJECTIVES: The aim of this study was to review randomized controlled trials (RCTs) using cardiac magnetic resonance (CMR) to assess myocardial infarct (MI) size in reperfused patients with ST-segment elevation myocardial infarction (STEMI). BACKGROUND: There is limited guidance on the use of CMR in clinical cardioprotection RCTs in patients with STEMI treated by primary percutaneous coronary intervention. METHODS: All RCTs in which CMR was used to quantify MI size in patients with STEMI treated with primary percutaneous coronary intervention were identified and reviewed...
March 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28273007/pediatric-brain-no-increased-signal-intensity-in-the-dentate-nucleus-on-unenhanced-t1-weighted-mr-images-after-consecutive-exposure-to-a-macrocyclic-gadolinium-based-contrast-agent
#3
Alexander Radbruch, Robert Haase, Philipp Kickingereder, Philipp Bäumer, Sebastian Bickelhaupt, Daniel Paech, Wolfgang Wick, Heinz-Peter Schlemmer, Angelika Seitz, Martin Bendszus
Purpose To determine the effect of at least five serial injections of the macrocyclic gadolinium-based contrast agent (GBCA) gadoterate meglumine on the signal intensity (SI) of the dentate nucleus (DN) of the pediatric brain on nonenhanced T1-weighted magnetic resonance (MR) images. Materials and Methods In this retrospective, institutional review board-approved study, 41 pediatric patients (age range, 3-17 years) who were imaged in at least five consecutive 1.5-T MR examinations with the exclusive use of gadoterate meglumine (plus a final additional nonenhanced MR imaging examination) were evaluated...
March 8, 2017: Radiology
https://www.readbyqxmd.com/read/28263424/feasibility-of-gadoteric-acid-for-delayed-gadolinium-enhanced-mri-of-cartilage-dgemric-at-the-wrist-and-knee-and-comparison-with-gd-dtpa
#4
Christoph Rehnitz, Bastian Klaan, Thuy Do, Alexander Barié, Hans-Ulrich Kauczor, Marc-André Weber
PURPOSE: To assess the feasibility of gadoteric acid for delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) and to compare the dGEMRIC values obtained using gadoteric acid with those obtained by an equimolar dose of Gd-DTPA. MATERIALS AND METHODS: At 3T, dGEMRIC of the wrist was performed twice using a T1 -weighted 3D-volumetric interpolated breath-hold examination sequence in 16 healthy volunteers (10 women; mean age 26.0 years) using gadoteric acid first and Gd-DTPA 3 weeks later...
March 6, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28144867/removal-of-gadolinium-based-contrast-agents-adsorption-on-activated-carbon
#5
María P Elizalde-González, Esmeralda García-Díaz, Mario González-Perea, Jürgen Mattusch
Three carbon samples were employed in this work, including commercial (1690 m(2) g(-1)), activated carbon prepared from guava seeds (637 m(2) g(-1)), and activated carbon prepared from avocado kernel (1068 m(2) g(-1)), to study the adsorption of the following gadolinium-based contrast agents (GBCAs): gadoterate meglumine Dotarem®, gadopentetate dimeglumine Magnevist®, and gadoxetate disodium Primovist®. The activation conditions with H3PO4 were optimized using a Taguchi methodology to obtain mesoporous materials...
January 31, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28141810/validation-of-blood-volume-fraction-quantification-with-3d-gradient-echo-dynamic-contrast-enhanced-magnetic-resonance-imaging-in-porcine-skeletal-muscle
#6
Stefan Hindel, Anika Söhner, Marc Maaß, Wolfgang Sauerwein, Dorothe Möllmann, Hideo Andreas Baba, Martin Kramer, Lutz Lüdemann
The purpose of this study was to assess the accuracy of fractional blood volume (vb) estimates in low-perfused and low-vascularized tissue using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). The results of different MRI methods were compared with histology to evaluate the accuracy of these methods under clinical conditions. vb was estimated by DCE-MRI using a 3D gradient echo sequence with k-space undersampling in five muscle groups in the hind leg of 9 female pigs. Two gadolinium-based contrast agents (CA) were used: a rapidly extravasating, extracellular, gadolinium-based, low-molecular-weight contrast agent (LMCA, gadoterate meglumine) and an extracellular, gadolinium-based, albumin-binding, slowly extravasating blood pool contrast agent (BPCA, gadofosveset trisodium)...
2017: PloS One
https://www.readbyqxmd.com/read/28125438/quantification-and-assessment-of-the-chemical-form-of-residual-gadolinium-in-the-brain-after-repeated-administration-of-gadolinium-based-contrast-agents-comparative-study-in-rats
#7
Thomas Frenzel, Chirag Apte, Gregor Jost, Laura Schöckel, Jessica Lohrke, Hubertus Pietsch
OBJECTIVE: Multiple clinical and preclinical studies have reported a signal intensity increase and the presence of gadolinium (Gd) in the brain after repeated administration of Gd-based contrast agents (GBCAs). This bioanalytical study in rat brain tissue was initiated to investigate whether the residual Gd is present as intact GBCA or in other chemical forms by using tissue fractionation and chromatography. MATERIALS AND METHODS: Rats were divided randomly in 6 groups of 10 animals each...
January 25, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28047012/we-fg-207b-01-best-in-physics-imaging-abdominal-ct-with-three-k-edge-contrast-materials-using-a-whole-body-photon-counting-scanner-initial-results-of-a-large-animal-experiment
#8
M Lakshmanan, R Symons, T Cork, C Davies-Venn, K Rice, A Malayeri, V Sandfort, D Bluemke, A Pourmorteza
PURPOSE: To demonstrate the feasibility of in vivo three-material decomposition techniques using photon-counting CT (PCCT) with possible advantage of resolving arterial and venous flow of an organ simultaneously. METHODS: Abdominal PCCT scans were acquired using a prototype whole-body PCCT with four energy thresholds (25/50/75/90keV) in a canine. Bismuth subsalicylate (60 mg) was administered orally one day prior to scanning. Immediately prior to CT scan, gadoteric acid (60 ml, Dotarem, Guerbet) was intravenously injected, followed in ten minutes by a 20mL injection of iodinated contrast (iopamidol 370 mg/mL, Bracco)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27977466/extremely-small-pseudoparamagnetic-iron-oxide-nanoparticle-as-a-novel-blood-pool-t1-magnetic-resonance-contrast-agent-for-3-t-whole-heart-coronary-angiography-in-canines-comparison-with-gadoterate-meglumine
#9
Eun-Ah Park, Whal Lee, Young Ho So, Yun-Sang Lee, Bong-Sik Jeon, Kyu Sung Choi, Eung-Gyu Kim, Wan-Jae Myeong
OBJECTIVE: The aim of this study was to evaluate an extremely small pseudoparamagnetic iron oxide nanoparticle (ESPIO), KEG3, as a potential blood pool agent in 3 T coronary magnetic resonance angiography (MRA) in canine models and compare its efficacy to that of a gadolinium-based contrast agent. MATERIALS AND METHODS: Nine mongrel dogs were subjected to whole-heart coronary MRA in 2 separate sessions at 7-day intervals with a 3 T scanner using the FLASH sequence with either gadoterate meglumine (Gd-DOTA) or the ESPIO (KEG3)...
February 2017: Investigative Radiology
https://www.readbyqxmd.com/read/27925871/no-signal-intensity-increase-in-the-dentate-nucleus-on-unenhanced-t1-weighted-mr-images-after-more-than-20-serial-injections-of-macrocyclic-gadolinium-based-contrast-agents
#10
Alexander Radbruch, Robert Haase, Pascal J Kieslich, Lukas D Weberling, Philipp Kickingereder, Wolfgang Wick, Heinz-Peter Schlemmer, Martin Bendszus
Purpose To determine the effect of more than 20 serial injections of macrocyclic gadolinium-based contrast agents (GBCAs) on the signal intensity (SI) of the dentate nucleus (DN) on unenhanced T1-weighted magnetic resonance (MR) images. Materials and Methods In this retrospective, institutional review board-approved study, 33 patients who underwent at least 20 consecutive MR imaging examinations (plus an additional MR imaging for reference) with the exclusive use of macrocyclic GBCAs gadoterate meglumine and gadobutrol were analyzed...
March 2017: Radiology
https://www.readbyqxmd.com/read/27842678/diagnostic-efficacy-and-safety-of-gadoteric-acid-mr-mammography-in-1537-patients
#11
Tim Seithe, Joachim Braun, Michael Wolf, Janis Vahldiek, Dajana Wolny, Jonas Auer, Joanna Pociej, Oliver Heine, Bernd Hamm, Maximilian de Bucourt
OBJECTIVES: To perform a large-scale multicenter post-marketing surveillance study for analyzing diagnostic effectiveness and safety of intravenous (IV) gadoteric acid (Dotarem(®)) in magnetic resonance (MR) mammography under daily practice conditions. MATERIALS AND METHODS: Patients underwent high-resolution MR mammography with gadoteric acid in 15 German centers. Radiologists used a standardized questionnaire to report data including patient demographics and medical history, characteristics of MR examination and results in terms of diagnosis and safety for the patient...
December 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27805440/quantitative-analysis-of-brain-perfusion-in-healthy-dogs-by-means-of-magnetic-resonance-imaging
#12
Antje Hartmann, Agnes Driesen, Ines E Lautenschläger, Volkher B Scholz, Martin J Schmidt
OBJECTIVE To determine values of perfusion parameters determined via MRI in the brains of healthy dogs. ANIMALS 10 healthy adult Beagles. PROCEDURES Each dog was anesthetized for MRI examination of the brain, including standard sequences and a perfusion-weighted sequence. Gadoteric acid (0.2 mmol/kg) was injected IV at a rate of 5 mL/s. A dedicated workstation was used to measure the times from contrast medium injection to arrival at an ROI (TO) and peak contrast enhancement (TTP), mean contrast medium transport time (MTT), and cerebral blood flow (CBF) in the caudate nucleus, thalamus, piriform lobe, hippocampus, semioval center, and temporal cerebral cortex...
November 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27726239/observational-study-on-the-safety-profile-of-gadoterate-meglumine-in-35-499-patients-the-secure-study
#13
Philippe Soyer, Anthony Dohan, Deepak Patkar, Andreas Gottschalk
PURPOSE: To investigate the safety of gadoterate meglumine and identify the incidence of nephrogenic systemic fibrosis (NSF). MATERIALS AND METHODS: An international prospective observational study was conducted from November 2008 to June 2013. A total of 35,499 adults and children who were scheduled to undergo contrast-enhanced MRI using gadoterate meglumine were analyzed (female, 53.1%; mean age: 49.5 years; range: 0-98 years). At least 3-month follow-up was planned for patients with an estimated creatinine clearance or glomerular filtration rate <60 mL/min (/1...
October 11, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27684794/lack-of-increased-signal-intensity-in-the-dentate-nucleus-after-repeated-administration-of-a-macrocyclic-contrast-agent-in-multiple-sclerosis-an-observational-study
#14
Philipp Eisele, Angelika Alonso, Kristina Szabo, Anne Ebert, Melissa Ong, Stefan O Schoenberg, Achim Gass
Recently, several studies reported increased signal intensity (SI) in the dentate nucleus (DN) after repeated application of gadolinium-based contrast agents (GBCAs), suggesting a deposition of gadolinium in this location. Patients with relapsing-remitting multiple sclerosis (RRMS) frequently show increased permeability of the blood-brain barrier as part of the inflammatory process in the brain parenchyma, which theoretically might increase the risk of gadolinium deposition. In this retrospective study, we investigated a possible increasing SI in the DN after repeated administrations of the macrocyclic contrast agent gadoterate meglumine...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27649101/delayed-gadolinium-enhanced-mr-imaging-of-cartilage-a-comparative-analysis-of-different-gadolinium-based-contrast-agents-in-an-ex-vivo-porcine-model
#15
Yusuhn Kang, Ja-Young Choi, Hye Jin Yoo, Sung Hwan Hong, Heung Sik Kang
Purpose To compare the delayed gadolinium-enhanced magnetic resonance (MR) imaging of cartilage (dGEMRIC) indexes acquired with different gadolinium-based contrast agents (GBCAs), with emphasis on the difference in electrical charge, and to evaluate the feasibility of the use of GBCAs other than gadopentetate dimeglumine with a double negative charge (Gd-DTPA(2-)) as alternatives at dGEMRIC. Materials and Methods Intact porcine patellae (n = 44) were divided into four groups according to GBCA used: Gd-DTPA(2-), double negative gadobenate dimeglumine (Gd-BOPTA(2-)), single negative gadoterate meglumine (Gd-DOTA(-)), and nonionic gadobutrol (Gd-DT-DO3A)...
March 2017: Radiology
https://www.readbyqxmd.com/read/27647272/assessment-of-dce-mri-parameters-for-brain-tumors-through-implementation-of-physiologically-based-pharmacokinetic-model-approaches-for-gd-dota
#16
Marios Spanakis, Eleftherios Kontopodis, Sophie Van Cauter, Vangelis Sakkalis, Kostas Marias
Dynamic-contrast enhanced magnetic resonance imaging (DCE-MRI) is used for detailed characterization of pathology of lesions sites, such as brain tumors, by quantitative analysis of tracer's data through the use of pharmacokinetic (PK) models. A key component for PK models in DCE-MRI is the estimation of the concentration-time profile of the tracer in a nearby vessel, referred as Arterial Input Function (AIF). The aim of this work was to assess through full body physiologically-based pharmacokinetic (PBPK) model approaches the PK profile of gadoteric acid (Gd-DOTA) and explore potential application for parameter estimation in DCE-MRI based on PBPK-derived AIFs...
October 2016: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/27509544/intravenous-gadoxetate-disodium-administration-reduces-breath-holding-capacity-in-the-hepatic-arterial-phase-a-multi-center-randomized-placebo-controlled-trial
#17
Taylor R McClellan, Utaroh Motosugi, Michael S Middleton, Brian C Allen, Tracy A Jaffe, Chad M Miller, Scott B Reeder, Claude B Sirlin, Mustafa R Bashir
Purpose To determine, in a multicenter double-blinded placebo-controlled trial, whether maximal hepatic arterial phase breath-holding duration is affected by gadoxetate disodium administration. Materials and Methods Institutional review board approval was obtained for this prospective multi-institutional HIPAA-compliant study; written informed consent was obtained from all subjects. At three sites, a total of 44 volunteers underwent a magnetic resonance (MR) imaging examination in which images were acquired before and dynamically after bolus injection of gadoxetate disodium, normal saline, and gadoterate meglumine, administered in random order in a single session...
February 2017: Radiology
https://www.readbyqxmd.com/read/27504794/adverse-reactions-to-gadoterate-meglumine-review-of-over-25-years-of-clinical-use-and-more-than-50-million-doses
#18
Eric de Kerviler, Kenneth Maravilla, Jean-François Meder, Olivier Naggara, Corinne Dubourdieu, Vincent Jullien, Pierre Desché
OBJECTIVE: The aim of this study was to evaluate the safety profile of gadoterate meglumine from clinical trials, postmarketing observational studies, and pharmacovigilance reports of adverse drug reactions (ADRs) encompassing 25 years of clinical use and over 50 million administered doses. MATERIALS AND METHODS: Assessment of the safety of gadoterate meglumine through processing and review of all safety data was collected after magnetic resonance imaging procedures...
September 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27495187/intraindividual-analysis-of-signal-intensity-changes-in-the-dentate-nucleus-after-consecutive-serial-applications-of-linear-and-macrocyclic-gadolinium-based-contrast-agents
#19
Alexander Radbruch, Lukas D Weberling, Pascal J Kieslich, Johanna Hepp, Philipp Kickingereder, Wolfgang Wick, Heinz-Peter Schlemmer, Martin Bendszus
PURPOSE: Recent studies reported an increase in the dentate nucleus (DN)-to-pons signal intensity (SI) ratio (DN-pons SI ratio) on unenhanced T1-weighted images in patients who received consecutive serial injections of linear gadolinium-based contrast agents (GBCAs). In contrast, most studies found no increase in the DN-pons SI ratio when patients were treated with consecutive serial injections of macrocyclic GBCAs. However, the potential difference between macrocyclic and linear GBCAs has never been assessed in individuals who received subsequent applications of both contrast agents...
November 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27373976/effectiveness-of-a-high-relaxivity-contrast-agent-administered-at-half-dose-in-dynamic-susceptibility-contrast-mri-of-brain-gliomas
#20
Girolamo Crisi, Silvano Filice, Gunter Erb, Francesca Bozzetti
PURPOSE: To determine whether half of the approved dose of gadobenate dimeglumine (MultiHance) is as effective as a full dose of gadoterate meglumine (Dotarem) for qualitative and quantitative cerebral blood volume (CBV) perfusion evaluation at 3T in patients with brain gliomas. MATERIALS AND METHODS: We enrolled 65 adult patients in an interindividual comparative study. Patients were randomized to one of two study arms: 33 patients received 0.1 mmol/kg body weight (bw) of gadoterate, 32 patients received 0...
July 4, 2016: Journal of Magnetic Resonance Imaging: JMRI
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