Aude Christelle Ka'e, Aubin Nanfack, Maria-Mercedes Santoro, Bouba Yagai, Georgia Ambada, Bertrand Sagnia, Alex Durand Nka, Ezechiel Ngoufack Jagni Semengue, Willy Pabo, Désiré Takou, Nelson Sonela, Vittorio Colizzi, Carlo-Federico Perno, Francesca Ceccherini-Silberstein, Sharon R Lewin, Caroline T Tiemessen, Joseph Fokam
INTRODUCTION: The success of antiretroviral therapy (ART) has changed HIV from a deadly to a chronic infection, thus increasing the transitioning from infancy toward adulthood. However, the virostatic nature of antiretrovirals maintains viruses in sanctuaries, with reactivation potentials. Because current ARTs are very limited for children, the emergence of new HIV epidemics driven by HIV drug-resistance mutations is favoured. Our systematic review aims to estimate the global burden of archived drug-resistance mutations (ADRMs) and the size of reservoir (HIV-1 DNA load), and their associated factors in children and adolescents...
October 10, 2023: BMJ Open