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Pelvic binding

Francisca Leal, Martin J Cohn
Limb reduction and loss are hallmarks of snake evolution. Although advanced snakes are completely limbless, basal and intermediate snakes retain pelvic girdles and small rudiments of the femur. Moreover, legs may have re-emerged in extinct snake lineages [1-5], suggesting that the mechanisms of limb development were not completely lost in snakes. Here we report that hindlimb development arrests in python embryos as a result of mutations that abolish essential transcription factor binding sites in the limb-specific enhancer of Sonic hedgehog (SHH)...
October 19, 2016: Current Biology: CB
Charalampos Karachalios, Panagiotis Bakas, Georgios Kaparos, Styliani Demeridou, Ilias Liapis, Charalampos Grigoriadis, Aggelos Liapis
Pelvic organ prolapse (POP) is a common multifactorial condition. Matrix metalloproteinases (MMPs) are enzymes capable of breaking down various connective tissue elements. Single-nucleotide polymorphisms (SNPs) in regulatory areas of MMP-encoding genes can alter their transcription rate, and therefore the possible effect on pelvic floor supporting structures. The insertion of an adenine (A) base in the promoter of the MMP-3 gene at position -1612/-1617 produces a sequence of six adenines (6A), whereas the other allele has five (5A)...
September 2016: Biomedical Reports
Vicki Nisenblat, Lucy Prentice, Patrick M M Bossuyt, Cindy Farquhar, M Louise Hull, Neil Johnson
BACKGROUND: About 10% of women of reproductive age suffer from endometriosis, a costly chronic disease causing pelvic pain and subfertility. Laparoscopy is the gold standard diagnostic test for endometriosis, but is expensive and carries surgical risks. Currently, there are no non-invasive tests available in clinical practice to accurately diagnose endometriosis. This review assessed the diagnostic accuracy of combinations of different non-invasive testing modalities for endometriosis and provided a summary of all the reviews in the non-invasive tests for endometriosis series...
2016: Cochrane Database of Systematic Reviews
Mahmut Kemal Ozbilgin, Caner Aktas, Elgin Turkoz Uluer, Mustafa Cagatay Buyukuysal, Manuchehr Salehi Gareveran, Cengiz Kurtman
OBJECTIVE: To investigate the reaction of versican and heparin-binding EGF-like growth factor (HB-EGF) molecule concentrations to acute radiation exposure in normal bladder and rectal tissue samples in order to gain more insight into the effects of cancer radiotherapy. STUDY DESIGN: Four groups with 6 male adult Swiss Albino mice per group were investigated. The mice bladder and rectum tissue samples were subjected to a 10-Gy single-dose radiation exposure in the pelvic region with a Co-60 teletherapy device and investigated 1, 2, and 7 days after radiation exposure, with 1 reference group which was not exposed to radiation...
April 2016: Analytical and Quantitative Cytopathology and Histopathology
Alexis Michenet, Marine Barbat, Romain Saintilan, Eric Venot, Florence Phocas
BACKGROUND: The genetic determinism of the calving and suckling performance of beef cows is little known whereas these maternal traits are of major economic importance in beef cattle production systems. This paper aims to identify QTL regions and candidate genes that affect maternal performance traits in the Blonde d'Aquitaine breed. Three calving performance traits were studied: the maternal effect on calving score from field data, the calving score and pelvic opening recorded in station for primiparous cows...
2016: BMC Genetics
Ping-Chia Li, Li-Fen Liu, Ming-Jia Jou, Hao-Kuang Wang
BACKGROUND: Glucagon-like peptide 1 (GLP-1) analogs protect a variety of cell types against oxidative damage and vascular and neuronal injury via binding to GLP-1 receptors. This study aimed to investigate the effects of the GLP-1 analogs exendin-4 and liraglutide on cerebral blood flow, reactive oxygen species production, expression of oxidative stress-related proteins, cognition, and pelvic sympathetic nerve-mediated bladder contraction after middle cerebral artery occlusion (MCAO) injury in the db/db mouse model of diabetes...
2016: BMC Neuroscience
J I Ahn, J-Y Yoo, T H Kim, Y I Kim, S D Ferguson, A T Fazleabas, S L Young, B A Lessey, J Y Ahn, J M Lim, J-W Jeong
Endometriosis is a major cause of infertility and pelvic pain, affecting more than 10% of reproductive-aged women. Progesterone resistance has been observed in the endometrium of women with this disease, as evidenced by alterations in progesterone-responsive gene and protein expression. cAMPResponse Element-Binding 3-like protein 1 (Creb3l1) has previously been identified as a progesterone receptor (PR) target gene in mouse uterus via high density DNA microarray analysis. However, CREB3L1 function has not been studied in the context of endometriosis and uterine biology...
2016: Current Molecular Medicine
Åsa H Everhov, Angelique Flöter Rådestad, Tommy Nyberg, Karin E Smedby, Karin Bergmark, Angelica Lindén Hirschberg
INTRODUCTION: Radiotherapy or radical hysterectomy with salpingo-oophorectomy (SOE) as treatment for uterine cervical cancer causes estrogen deprivation in premenopausal women. The effects on androgen production have rarely been examined but could be relevant for survivors of cervical cancer because insufficiency has been associated with low sexual function. AIM: To investigate the effects of pelvic radiotherapy, hysterectomy with SOE, or surgery without SOE on androgen levels and to explore potential associations with sexual function...
March 2016: Journal of Sexual Medicine
Gül Yeşiltepe Mutlu, Heves Kırmızıbekmez, Akie Nakamura, Maki Fukami, Şükrü Hatun
Hypoparathyroidism, deafness, and renal dysplasia (HDR; OMIM 146255) syndrome is a rare disease, inherited dominantly and found to be related with GATA3 (GATA binding protein 3) gene mutations. A 13-year and 8-month-old boy who presented with hypocalcemia was diagnosed with hypoparathyroidism. He also had dysmorphic facial features, renal anomaly (pelvic kidney), and mild sensorineural hearing loss. His cranial computed tomography revealed multiple calcifications in bilateral centrum semiovale, corona radiata, and basal ganglions suggesting a persistent hypoparathyroidism...
December 2015: Journal of Clinical Research in Pediatric Endocrinology
Haibo Zhang, Xianwen Dong, Zhisheng Wang, Aiming Zhou, Quanhui Peng, Huawei Zou, Bai Xue, Lizhi Wang
This study was conducted to estimate the effect of dietary conjugated linoleic acids (CLA) on intramuscular and subcutaneous fat deposition in Yellow Breed × Simmental cattle. The experiment was conducted for 60 days. The results showed that the average backfat thickness, (testicles + kidney + pelvic) fat percentage and subcutaneous fat percentage in dietary CLA were significantly lower than in the control group, while intramuscular the fat percentage was significantly higher. Compared to the control group, the Longissimus muscle enzyme activities of lipoprotein lipase (LPL), fatty acid synthase (FAS) and acetyl-coenzyme A carboxylase (ACC) in dietary CLA and the subcutaneous fat enzyme activities of LPL, hormone-sensitive lipase (HSL) and carnitine palmitoyltransferase-1 (CPT-1) were significantly increased...
April 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
Carsten-Oliver Sahlmann, Birgit Meller, Caroline Bouter, Christian Oliver Ritter, Philipp Ströbel, Joachim Lotz, Lutz Trojan, Johannes Meller, Sameh Hijazi
PURPOSE: Binding of (68)Ga-PSMA-HBED-CC ((68)Ga-PSMA) at prostate cancer (PC) cells increases over time. A biphasic protocol may help separating benign from tumor lesions. The aim of this study was the retrospective evaluation of a diagnostic incremental value of a dual-time point (biphasic) (68)Ga-PSMA-PET/CT in patients with prostate cancer. METHODS: Retrospective analysis of 35 consecutive patients (49-78 years, median 71) with newly diagnosed PC (12/35) or recurrence of PC (23/35)...
May 2016: European Journal of Nuclear Medicine and Molecular Imaging
Jazmin Castro, Germán Araya, Pamela Inostroza, Paulina Hidalgo, Reinaldo González-Ramos, Hugo Sovino, M Angélica Boric, Ariel Fuentes, M Cecilia Johnson
BACKGROUND: Endometriosis, pro-inflammatory and invasive benign disease estrogen dependent, abnormally express in endometria the enzyme P450Arom, positively regulated by steroid factor-1 (SF-1). Our objective was to study the nuclear protein contents of upstream stimulating factor 2 (USF2a and USF2b), a positive regulator of SF-1, throughout the menstrual cycle in eutopic endometria from women with and without (control) endometriosis and the involvement of nuclear estrogen receptors (ER) and G-coupled protein estrogen receptor (GPER)-1...
2015: Biological Research
Ryszard A Zielke, Igor H Wierzbicki, Benjamin I Baarda, Aleksandra E Sikora
BACKGROUND: Neisseria gonorrhoeae (GC) is a Gram-negative pathogen that most commonly infects mucosal surfaces, causing sexually transmitted urethritis in men and endocervicitis in women. Serious complications associated with these infections are frequent and include pelvic inflammatory disease, ectopic pregnancy, and infertility. The incidence of gonorrhea cases remains high globally while antibiotic treatment options, the sole counter measures against gonorrhea, are declining due to the remarkable ability of GC to acquire resistance...
2015: BMC Microbiology
Ying-Ying Yu, Cui-Xiang Sun, Yin-Kun Liu, Yan Li, Li Wang, Wei Zhang
OBJECTIVE: To compare genome-wide DNA methylation profiles in ovary tissue from women with polycystic ovary syndrome (PCOS) and healthy controls. DESIGN: Case-control study matched for age and body mass index. SETTING: University-affiliated hospital. PATIENT(S): Ten women with PCOS who underwent ovarian drilling to induce ovulation and 10 healthy women who were undergoing laparoscopic sterilization, hysterectomy for benign conditions, diagnostic laparoscopy for pelvic pain, or oophorectomy for nonovarian indications...
July 2015: Fertility and Sterility
Yun Wang, Meijuan Zhang, Fang Xie, Xueyang Li, Mengmeng Bao, Ning Yang, Rong Shi, Zhenyuan Wang, Anshi Wu, Yun Guan, Yun Yue
Pelvic organ cross-sensitization, also termed as viscero-visceral referred hyperalgesia, is a major contributor to painful endometriosis. Its underlying mechanism is poorly understood. Clinical and basic studies have shown that gabapentin, a drug that binds to the α2δ-1 subunit of voltage-dependent calcium channels (Cavα2δ-1), is effective in treating chronic visceral pain. Accordingly, we hypothesized that pelvic organ cross-sensitization in painful endometriosis is mediated by an upregulation of Cavα2δ-1 in the spinal cord...
June 2015: Neurochemical Research
Wan Lee, Yeonghoon Son, Hyosun Jang, Min Ji Bae, Jungki Kim, Dongil Kang, Joong Sun Kim
PURPOSE: Pelvic irradiation for the treatment of cancer can affect normal cells, such as the rapidly proliferating spermatogenic cells of the testis, leading to infertility, a common post-irradiation problem. The present study investigated the radioprotective effect of rolipram, a specific phosphodiesterase type-IV inhibitor known to increase the expression and phosphorylation of the cyclic adenosine monophosphate response element-binding protein (CREB), a key factor for spermatogenesis, with the testicular system against pelvic irradiation...
April 2015: World Journal of Men's Health
Wentao Liu, Lin Qi, Hui Lv, Xiongbing Zu, Minfeng Chen, Jun Wang, Longfei Liu, Feng Zeng, Yuan Li
BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNAs that silence their cognate target genes by specifically binding and cleaving messenger RNAs or inhibiting their translation. In this study, we explored whether miRNA-141 and miRNA-200b are involved in regulation of the invasive ability and epithelial-mesenchymal transition (EMT) of bladder cancer cells in vitro. We also evaluated their potential as biomarkers for deciding the extent of pelvic lymph node dissection (PLND) required during radical cystectomy...
2015: BMC Cancer
Katherine L O'Shaughnessy, Randall D Dahn, Martin J Cohn
The earliest known vertebrate copulatory organs are claspers, paired penis-like structures that are associated with evolution of internal fertilization and viviparity in Devonian placoderms. Today, only male chondrichthyans possess claspers, which extend from posterior pelvic fins and function as intromittent organs. Here we report that clasper development from pelvic fins of male skates is controlled by hormonal regulation of the Sonic hedgehog (Shh) pathway. We show that Shh signalling is necessary for male clasper development and is sufficient to induce clasper cartilages in females...
2015: Nature Communications
Wentao Liu, Lin Qi, Hui Lv, Xiongbing Zu, Minfeng Chen, Jun Wang, Longfei Liu, Feng Zeng, Yuan Li
BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNAs that silence their cognate target genes by specifically binding and cleaving messenger RNAs or inhibiting their translation. In this study, we explored whether miRNA-141 and miRNA-200b are involved in regulation of the invasive ability and epithelial-mesenchymal transition (EMT) of bladder cancer cells in vitro. We also evaluated their potential as biomarkers for deciding the extent of pelvic lymph node dissection (PLND) required during radical cystectomy...
2015: BMC Cancer
Carmine Zoccali, Jesse Skoch, Apar Patel, Christina M Walter, Philip Maykowski, Ali A Baaj
PURPOSE: Pelvic and sacral surgeries are considered technically difficult due to the complex multidimensional anatomy and the presence of significant neurovascular structures. Knowledge of the key neurovascular anatomy is essential for safe and effective execution of partial and complete sacral resections. The goal of this anatomic, cadaveric study is to describe the pertinent neurovascular anatomy during these procedures. METHODS: Three embalmed human cadaveric specimens were used...
May 2015: European Spine Journal
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