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https://www.readbyqxmd.com/read/29770441/evaluation-of-the-anti-inflammatory-activity-of-tinospora-cordifolia-willd-miers-chloroform-extract-a-preclinical-study
#1
Sheena Philip, Greeshma Tom, Asha V Vasumathi
OBJECTIVES: Tinospora cordifolia (Willd.) Miers is an inevitable ingredient of Ayurvedic rasayanas for the treatment of disorders with unregulated inflammation. However, studies regarding the mechanism of anti-inflammatory potential of this plant at the molecular level are lacking. METHODS: In vitro evaluations were conducted in RAW264.7 macrophages which were preincubated with chloroform extract of T. cordifolia (CETC) and subsequently stimulated with LPS. The expressions of COX-2, TNF-α and iNOS genes were analysed by SQRT-PCR and Western blot, cytokines (IL-6, IL-1β and PGE2 ) levels by ELISA, NF-κB activation and p38 MAPK phosphorylation by Immunoblot and confocal imaging...
May 16, 2018: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29755225/classification-of-electrophotonic-images-of-yogic-practice-of-mudra-through-neural-networks
#2
Kotikalapudi Shiva Kumar, T M Srinivasan, Judu Ilavarasu, Biplob Mondal, H R Nagendra
Background: Mudras signify a gesture with hands, eyes, and the body. Different configurations of the joining of fingertips are also termed mudra and are used by yoga practitioners for energy manipulation and for therapeutic applications. Electrophotonic imaging (EPI) captures the coronal discharge around the fingers as a result of electron capture from the ten fingers. The coronal discharge around each fingertip is studied to understand the effect of mudra on EPI parameters. Methods: The participants were from Swami Vivekananda Yoga Anusandhana Samsthana and Sushrutha Ayurvedic Medical College, in Bengaluru, India...
May 2018: International Journal of Yoga
https://www.readbyqxmd.com/read/29754136/unravelling-the-nerds-syndrome
#3
Achintya Dinesh Singh, Tejas Menon Suri, Rakesh Kumar Jagdish, Uma Kumar
A 22-year-old man presented with symmetric polyarthritis, pruritus and deviation of angle of mouth to the right side since the last 7 years. His symptoms were persistent despite receiving ayurvedic medications and symptomatic therapy. Examination revealed dry skin, cutaneous nodules, xanthelasma, periarticular non-tender swellings, pitting oedema of hands and feet and lower motor neuron type right facial palsy. Haematological investigations revealed eosinophilia and skin biopsy had cutaneous eosinophilic infiltration...
May 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29747755/the-potential-of-three-different-pcr-related-approaches-for-the-authentication-of-mixtures-of-herbal-substances-and-finished-herbal-medicinal-products
#4
Kirsten Doganay-Knapp, Annika Orland, Gabriele M König, Werner Knöss
BACKGROUND: Herbal substances and preparations thereof play an important role in healthcare systems worldwide. Due to the variety of these products regarding origin, composition and processing procedures, appropriate methodologies for quality assessment need to be considered. A majority of herbal substances is administered as multicomponent mixtures, especially in the field of Traditional Chinese Medicine and ayurvedic medicine, but also in finished medicinal products. Quality assessment of complex mixtures of herbal substances with conventional methods is challenging...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29746995/rising-trade-declining-stocks-the-global-gugul-commiphora-wightii-trade
#5
REVIEW
A B Cunningham, J A Brinckmann, R N Kulloli, U Schippmann
ETHNOPHARMACOLOGICAL RELEVANCE: Commiphora wightii is exploited in India and Pakistan for an oleo-resin (gum guggul) traditionally used in Ayurvedic, Siddha and Unani medical systems. Processed C. wightii oleo-resin products are exported from India to 42 countries, including re-export to Pakistan, for anti-inflammatory use and as an anti-inflammatory and an anti-obesity treatment considered to lower cholesterol and lipid levels. The C. wightii export trade has particular relevance to the European Union because Belgium, France, Germany, Hungary, Italy, the Netherlands, and United Kingdom are importing countries...
May 7, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29678603/chebulagic-acid-chebulinic-acid-and-gallic-acid-the-active-principles-of-triphala-inhibit-tnf%C3%AE-induced-pro-angiogenic-and-pro-inflammatory-activities-in-retinal-capillary-endothelial-cells-by-inhibiting-p38-erk-and-nfkb-phosphorylation
#6
Sivasankar Shanmuganathan, Narayanasamy Angayarkanni
Tumor necrosis factor-α (TNFα) a pleiotropic cytokine induces pro-inflammatory and pro-angiogenic changes in conditions such as diabetic retinopathy (DR) and neovascular age related macular degeneration (NV-AMD). Hence, inhibition of TNFα mediated changes can benefit the management of DR and NV-AMD. Triphala, an ayurvedic herbal preparation is known to have immunomodulatry functions. In this study we evaluated the alcoholic extract of triphala (AlE) and its compounds Chebulagic acid (CA), Chebulinic acid (CI) and Gallic acid (GA) for their anti-TNFα activity...
April 17, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29655677/an-in-vitro-and-in-vivo-study-of-a-4-herb-formula-on-the-management-of-diet-induced-metabolic-syndrome
#7
Elaine Wat, Yanping Wang, Ken Chan, Hon Wai Law, Chi Man Koon, Kit Man Lau, Ping Chung Leung, Choly Yan, Clara Bik San Lau
BACKGROUND: Metabolic syndrome is the cluster of risk factors that leads to increased episodes of cardiovascular disease (CVD). These risk factors include but are not limited to obesity, non-alcoholic fatty liver (NAFLD), dyslipidemia, and type 2 diabetes. Since the pathogenesis of metabolic syndrome has multiple metabolic origins, there is no single treatment for it. Pharmacological approaches consist of separate drugs which target at individual risk factors which pose various side effects...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29620265/ashwagandha-root-extract-exerts-anti%C3%A2-inflammatory-effects-in-hacat-cells-by-inhibiting-the-mapk-nf%C3%A2-%C3%AE%C2%BAb-pathways-and-by-regulating-cytokines
#8
Abudubari Sikandan, Takahisa Shinomiya, Yukitoshi Nagahara
A paste composed of the boiled leaves and roots of the Ashwagandha plant is used to cure ulcer and swelling in Ayurvedic medicine. However, the effects of the hot water extract of Ashwagandha roots (ASH‑WEX), which is also used in Ayurveda, on skin have not been fully elucidated. Therefore, the present study investigated the anti‑inflammatory activity of ASH‑WEX on skin, by using the human keratinocyte cell line HaCaT. The results indicated that ASH‑WEX significantly inhibited mRNA expression of inflammatory cytokines, including interleukin (IL)‑8, IL‑6, tumor necrosis factor (TNF‑α), IL‑1β and IL‑12, and promoted the mRNA expression of the anti‑inflammatory cytokine transforming growth factor (TGF)‑β1 in HaCaT cells...
April 2, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29619331/phytochemical-analysis-and-in-vitro-biochemical-characterization-of-aqueous-and-methanolic-extract-of-triphala-a-conventional-herbal-remedy
#9
Romana Parveen, Tooba Naz Shamsi, Gurjeet Singh, Teeba Athar, Sadaf Fatima
Triphala, an Indian ayurvedic triherbal formulation, is an equiproportional mixture of fruits of three herbs, amalaki ( Emblica officinalis ), haritaki ( Terminalia chebula ) and bibhitaki ( Terminalia bellerica ). The present study focused on phytocompounds detection and comparative analysis of various biochemical activities in the aqueous and methanolic extracts of triphala and its constituting herbs. Antioxidant activity was determined by 1, 1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), super oxide dismutase (SOD), catalase assay...
March 2018: Biotechnology Reports
https://www.readbyqxmd.com/read/29609927/complementary-and-alternative-medicine-for-rheumatic-diseases-a-systematic-review-of-randomized-controlled-trials
#10
REVIEW
Jie Kie Phang, Yu Heng Kwan, Hendra Goh, Victoria Ie Ching Tan, Julian Thumboo, Truls Østbye, Warren Fong
OBJECTIVES: To summarize all good quality randomized controlled trials (RCTs) using complementary and alternative medicine (CAM) interventions in patients with rheumatic diseases. METHODS: A systematic literature review guided by the Preferred Reporting Items for Systematic review and Meta-Analysis (PRISMA) was performed. We excluded non-English language articles and abstract-only publications. Due to the large number of RCTs identified, we only include "good quality" RCTs with Jadad score of five...
April 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29606113/md-1-a-poly-herbal-formulation-indicated-in-diabetes-mellitus-ameliorates-glucose-uptake-and-inhibits-adipogenesis-an-in-vitro-study
#11
Srivani Telapolu, Mangathayaru Kalachavedu, Alan Mathew Punnoose, Dwarakanath Bilikere
BACKGROUND: Type 2 Diabetes (T2D) is a polygenic disease requiring a multipronged therapeutic approach. In the current scenario, the use of polyherbals is increasing among the diabetics. MD-1, a poly herbal formulation is constituted as a mixture of six popular anti diabetic herbs, used in the management of Diabetes mellitus (DM). The physicochemical, biochemical and in vitro efficacy studies have been carried out to ascertain the possible mechanisms underlying the anti-diabetic action of MD-1...
April 2, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29604378/taste-of-phytocompounds-a-better-predictor-for-ethnopharmacological-activities-of-medicinal-plants-than-the-phytochemical-class
#12
Dorin Dragos, Marilena Gilca
ETHNOPHARMACOLOGICAL RELEVANCE: Understanding the patterns that shape traditional medical knowledge is essential for accelerating ethnopharmacological progress. According to Ayurveda, medicinal plants that belong to different taxa, but which have similar taste, may display similar (ethno)pharmacological activities (EPAs) (Bhishagratna, 1998; Sharma and Dash, 2006). AIM OF THE STUDY: To understand the patterns that govern the distribution of herbal EPAs in Ayurveda and to evaluate the potential concordance between chemical class or taste of the constituent phytocompounds and EPAs...
March 28, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29601073/do-ayurveda-drugs-induce-liver-injury
#13
COMMENT
Galib Ruknuddin
Drugs fulfilling the criterion of a standard drug will always become panacea provided, if they are used properly. On the other hand, a poorly manufactured drug however used skillfully, will prove to be a poison. Texts of Ayurveda, do mention hazards of drugs, which are not properly manufactured or administered. Art of drug administration is unique in this ancient medical science that cautions towards concentrating on dose, indications, contra-indications, suitable vehicle, specific diet, certain restrictions etc ...
March 27, 2018: World Journal of Hepatology
https://www.readbyqxmd.com/read/29580105/herbal-remedies-a-boon-for-diabetic-neuropathy
#14
Reshu Tiwari, Mohd Haris Siddiqui, Tarique Mahmood, Paramdeep Bagga, Farogh Ahsan, Arshiya Shamim
Diabetic neuropathy is a chronic complication of diabetes mellitus affecting about 50% of patients. Its symptoms include decreased motility and severe pain in peripheral parts. The pathogenesis involved is an abnormality in blood vessels that supply the peripheral nerves, metabolic disorders such as myo-inositol depletion, and increased nonenzymatic glycation. Moreover, oxidative stress in neurons results in activation of multiple biochemical pathways, which results in the generation of free radicals. Apart from available marketed formulations, extensive research is being carried out on herbal-based natural products to control hyperglycemia and its associated complications...
March 26, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29576440/evolution-of-dietary-preferences-and-the-innate-urge-to-heal-drug-discovery-lessons-from-ayurveda
#15
REVIEW
Akhila Hosur Shrungeswara, Mazhuvancherry Kesavan Unnikrishnan
Highly specialized and functionally integrated cognitive systems facilitate hedonistic and healthy food preferences. Guided by survival needs, flavor preferences not only select safe, nutritious dietary components, but also those with negligible calorific value but significant health benefits, for example, spices. Feeding behavior, both innate and acquired, is guided not only by taste receptors on the tongue but also visceral organs. The gustatory cortex receives information from all senses, not just taste, suggesting multiple checkpoints in predicting and evaluating healthy foods...
March 22, 2018: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29568197/assessment-of-in-vivo-antiviral-potential-of-datura-metel-linn-extracts-against-rabies-virus
#16
Soumen Roy, Lalit Samant, Rajeshkumar Ganjhu, Sandeepan Mukherjee, Abhay Chowdhary
Objective: The soxhlet, cold, and ayurvedic extracts of Datura metel Linn. were evaluated for in vivo antirabies activity. Materials and Methods: Soxhlet and cold extraction method were used to extract Datura (fruit and seed) extracts, and ayurvedic extraction of Datura was prepared. In vivo toxicity assay was performed as per the OECD 420. LD50 dose was calculated by Reed and Muench method. The in vivo antirabies activity was screened in Swiss albino mice with the virus challenge dose of 10 LD50 (intracerebrally) in both preexposure (PE) and postexposure treatment with oral administration of Datura extracts in Swiss albino mice and observed for 21 days...
January 2018: Pharmacognosy Research
https://www.readbyqxmd.com/read/29568169/efficacy-of-ayurvedic-drugs-as-compared-to-chlorhexidine-in-management-of-chronic-periodontitis-a-randomized-controlled-clinical-study
#17
Neelam Mittal, Vinod Kumar Joshi, Ratan Kumar Srivastava, Shri Prakash Singh
Background: In India, Ayurveda is considered to be more effective and cheaper than modern medicine. Ayurvedic literature shows its use in treating oral diseases also. However, their effectiveness, in comparison with the allopathic mode of management, has not been assessed previously. The aim of this randomized controlled clinical trial was to compare the efficacy of ayurvedic drugs over chlorhexidine in treating chronic periodontitis. Materials and Methods: Four hundred and eight participants, in the age group 20-49 years, suffering from mild-to-moderate chronic periodontitis were included in this study...
January 2018: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29555257/biomedical-waste-management-in-ayurveda-hospitals-current-practices-future-prospectives
#18
REVIEW
Renju Rajan, Delvin T Robin, Vandanarani M
Biomedical waste management is an integral part of traditional and contemporary system of health care. The paper focuses on the identification and classification of biomedical wastes in Ayurvedic hospitals, current practices of its management in Ayurveda hospitals and its future prospective. Databases like PubMed (1975-2017 Feb), Scopus (1960-2017), AYUSH Portal, DOAJ, DHARA and Google scholar were searched. We used the medical subject headings 'biomedical waste' and 'health care waste' for identification and classification...
March 16, 2018: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29555255/punica-granatum-improves-renal-function-in-gentamicin-induced-nephropathy-in-rats-via-attenuation-of-oxidative-stress
#19
Snehal N Mestry, Nitin B Gawali, Sarayu A Pai, Malvika S Gursahani, Jayesh B Dhodi, Renuka Munshi, Archana R Juvekar
BACKGROUND: Gentamicin is widely used as an antibiotic for the treatment of gram negative infections. Evidences indicates that oxidative stress is involved in gentamicin-induced nephrotoxicity. In Ayurvedic medicine, Punica granatum Linn. is considered as 'a pharmacy unto itself". It has been claimed in traditional literature, to treat various kidney ailments due to its antioxidant potential. OBJECTIVE: To explore the possible mechanism of action of methanolic extract of P...
March 16, 2018: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29530454/neuropharmacological-evaluation-on-four-traditional-herbs-used-as-nervine-tonic-and-commonly-available-as-shankhpushpi-in-india
#20
Neeraj K Sethiya, Alok Nahata, Pawan Kumar Singh, S H Mishra
OBJECTIVE: The present study was undertaken to evaluate the neuropharmacological effect of four herbs commonly identified as source of Shankhpushpi. BACKGROUND: Shankhpushpi is an Ayurvedic drug, widely used for its actions on the central nervous system, especially to improve intellect and boost memory. Four botanicals viz. Canscora decussata Schult. (CD), Clitorea ternatea Linn. (CT), Convolvulus pluricaulis Choisy. (CP) and Evolvulus alsinoides Linn. (EA) are considered as sources of Shankhpushpi by Indian practitioners on the basis of their morphological descriptions given in ancient texts...
March 9, 2018: Journal of Ayurveda and Integrative Medicine
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