Claudia I Perez, Jorge Luis-Islas, Axel Lopez, Xarenny Diaz, Omar Molina, Benjamin Arroyo, Mario G Moreno, Elvi Gil Lievana, Esmeralda Fonseca, Gilberto Castañeda-Hernández, Ranier Gutierrez
Obesity is a major global health epidemic that has adverse effects on both the people affected as well as the cost to society. Several anti-obesity drugs that target GLP-1 receptors have recently come to the market. Here, we describe the effects of tesofensine, a novel anti-obesity drug that acts as a triple monoamine neurotransmitter reuptake inhibitor. Using various techniques, we investigated its effects on weight loss and underlying neuronal mechanisms in mice and rats. These include behavioral tasks, DeepLabCut videotaped analysis, electrophysiological ensemble recordings, optogenetic activation, and chemogenetic silencing of GABAergic neurons in the Lateral Hypothalamus (LH)...
2024: PloS One