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https://www.readbyqxmd.com/read/28107773/safety-and-effectiveness-of-tofogliflozin-in-elderly-japanese-patients-with-type-2-diabetes-mellitus-a-post-marketing-study-j-step-el-study
#1
Kazunori Utsunomiya, Naoki Shimmoto, Masayuki Senda, Yuji Kurihara, Ryoji Gunji, Shoko Fujii, Seigo Kakiuchi, Hisataka Fujiwara, Hiroyuki Kameda, Masahiro Tamura, Kohei Kaku
AIMS/INTRODUCTION: While sodium glucose cotransporter 2 inhibitors are a promising treatment for type 2 diabetes mellitus, they are associated with concerns about specific adverse drug reactions. We conducted a 1-year post-marketing study of tofogliflozin, a novel agent in this class, in Japanese elderly patients with type 2 diabetes mellitus. MATERIALS AND METHODS: This was a prospective, observational, and multicenter post-marketing study conducted in the context of routine clinical practice...
January 20, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28107666/development-of-a-microwave-energy-delivery-system-for-reversible-stunning-of-cattle
#2
D McLean, L Meers, J Ralph, J S Owen, A Small
Stunning prior to slaughter is commonly used to render the animal insensible to pain. However, for certain markets, stunning is disallowed, unless the animal can fully recover if not slaughtered. There are very few available methods of inducing a fully recoverable stun. This paper describes the development of a microwave energy application system for stunning cattle. Cadaver heads were used to demonstrate that brain temperature could be raised to a point at which insensibility would be expected to occur (44°C), and to calculate the power and time combinations required to achieve this in a range of cattle weights...
January 7, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28107530/broad-scale-genetic-diversity-of-cannabis-for-forensic-applications
#3
Christophe Dufresnes, Catherine Jan, Friederike Bienert, Jérôme Goudet, Luca Fumagalli
Cannabis (hemp and marijuana) is an iconic yet controversial crop. On the one hand, it represents a growing market for pharmaceutical and agricultural sectors. On the other hand, plants synthesizing the psychoactive THC produce the most widespread illicit drug in the world. Yet, the difficulty to reliably distinguish between Cannabis varieties based on morphological or biochemical criteria impedes the development of promising industrial programs and hinders the fight against narcotrafficking. Genetics offers an appropriate alternative to characterize drug vs...
2017: PloS One
https://www.readbyqxmd.com/read/28107374/combining-social-norms-and-social-marketing-to-address-underage-drinking-development-and-process-evaluation-of-a-whole-of-community-intervention
#4
Sandra C Jones, Kelly Andrews, Kate Francis
Youth alcohol consumption has been steadily declining in Australia, as in other countries; fewer young people are drinking and the age of initiation is increasing. However, young people, their parents and others in their communities continue to believe that adolescent (excessive) drinking is the norm. This perception, and the concurrent misperception that the majority of parents are happy to provide their underage children with alcohol, creates a perceived culture of acceptance of youth alcohol consumption...
2017: PloS One
https://www.readbyqxmd.com/read/28107173/electronic-cigarettes-and-indoor-air-quality-a-review-of-studies-using-human-volunteers
#5
Najihah Zainol Abidin, Emilia Zainal Abidin, Aziemah Zulkifli, Karmegam Karuppiah, Sharifah Norkhadijah Syed Ismail, Amer Siddiq Amer Nordin
OBJECTIVE: This paper is primarily aimed to review articles on electronic cigarettes (e-cigarettes) focusing on indoor air quality (IAQ) assessment that were conducted using human volunteers under natural settings that mimic actual vaping scenarios. Such studies may give a better representation of the actual potential exposure towards e-cigarettes emissions in indoor settings. METHODS: A systematic literature search was conducted using PubMed search engine database...
January 20, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28107111/the-effects-of-defamilization-and-familization-measures-on-the-accumulation-of-retirement-income-for-women-in-the-uk
#6
Ruby C M Chau, Liam Foster, Sam W K Yu
This article is concerned with the link between the effects of pro-market pension reforms on women and familization/defamilization measures. It aims to contribute to the study of this link in three ways. Firstly, it identifies defamilization/familization measures that have the potential to reduce negative effects of pro-market pension measures on women. Secondly, based on the examples from the United Kingdom, it shows that the government's willingness to provide sufficient defamilization/familization measures to assist women to deal with the negative effects of the pro-market pension measures should not be taken for granted...
January 20, 2017: Journal of Women & Aging
https://www.readbyqxmd.com/read/28107087/comparison-of-fatty-acid-composition-in-selected-dietary-supplements-containing-conjugated-linoleic-acid
#7
Dorota Derewiaka, Klara Nestorowicz, Rafał Wołosiak
The market of pharmaceutical products is offering a wide range of supplements. Most of the consumers believe that these products will improve their state of health, but are they getting what they want and what they are paying for? The aim of the study was to evaluate the quality of selected dietary supplements containing conjugated linoleic acid (CLA). All supplements were available in the Warsaw markets and bought from pharmacies. Assessment of the quality of food supplements was achieved by analysis of fatty acid using gas chromatography coupled with a mass spectrometer...
January 20, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28106361/how-has-the-affordable-care-act-affected-work-and-wages
#8
Jean Abraham, Anne Beeson Royalty
In a review of the evidence, the authors find that the ACA had minimal effect on employment, hours of work, and compensation. This brief provides critical perspective on the effects of reforms on labor markets for federal and state policymakers as they consider changing or repealing the law.
2017: LDI Issue Brief
https://www.readbyqxmd.com/read/28106272/health-claims-and-methodological-controversy-in-nutrition-science
#9
Oliver Todt, José Luis Luján
This article analyzes the debate about data acquisition and assessment in health claims regulation by identifying the underlying controversies on methodological choice. Regulation in the European Union imposes the need for a scientific substantiation of all health claims (claims about a relationship between consumption of certain food ingredients and positive health effects). Randomized controlled trials (RCTs) are the method that generally is considered to provide the highest quality data for decision making in claims regulation because they allow for establishing cause-effect relationships...
January 20, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28106231/a-case-control-study-of-cemented-acetabular-total-hip-arthroplasty-components-in-patients-less-than-50-with-5-year-minimum-follow-up
#10
Thomas F M Yeoman, William Smy, Paul Gaston
BACKGROUND: This study investigates the outcomes of cemented sockets in young patients (<50 years) requiring a total hip replacement (THR) compared to older patients (>50 years) having the same procedure, under the same surgeon between June 2005 and May 2009. METHODS: Prosthesis survivorship rates, patient outcomes and radiological findings were compared between a consecutive series of 56 young patients (mean 42, range 25-49) and 56 older patients (mean 69, range 53-81) that underwent a primary THR using a cemented Stryker® Exeter™ Contemporary™ flanged cup...
January 20, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28105725/antifungal-peptides-a-potential-new-class-of-antifungals-for-treating-vulvovaginal-candidiasis-caused-by-fluconazole-resistant-candida-albicans
#11
Siew Mei Samantha Ng, Yi Yong Alvin Yap, Jin Wei Darryl Cheong, Fui Mee Ng, Qiu Ying Lau, Timothy Barkham, Jeanette Woon Pei Teo, Jeffrey Hill, Cheng San Brian Chia
Vulvovaginal candidiasis/candidosis is a common fungal infection afflicting approximately 75% of women globally caused primarily by the yeast Candida albicans. Fluconazole is widely regarded as the antifungal drug of choice since its introduction in 1990 due to its high oral bioavailability, convenient dosing regimen and favourable safety profile. However, its widespread use has led to the emergence of fluconazole-resistant C. albicans, posing a universal clinical concern. Coupled to the dearth of new antifungal drugs entering the market, it is imperative to introduce new drug classes to counter this threat...
January 19, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28105565/what-are-the-socioeconomic-implications-of-the-value-chain-of-biodiversity-products-a-case-study-in-northeastern-brazil
#12
Rafael Ricardo Vasconcelos da Silva, Laura Jane Gomes, Ulysses Paulino Albuquerque
The trade in biodiversity products has gained increasing importance in conservation and livelihood strategies. The aim of this study is to describe and analyze the socioeconomic aspects and dynamics of the production and commercialization of two important products of Brazilian biodiversity from the fruits of Caryocar coriaceum Wittm. and Dimorphandra gardneriana Tul. Interviews were conducted with who were involved in the various stages of value chains. Data were analyzed under an analytical/descriptive approach...
February 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28105530/molecular-characterization-of-a-novel-reassortant-h7n6-subtype-avian-influenza-virus-from-poultry-in-eastern-china-in-2016
#13
Haibo Wu, Rufeng Lu, Xiuming Peng, Xiaorong Peng, Bin Chen, Linfang Cheng, Nanping Wu
During the surveillance for avian influenza viruses (AIVs) in live poultry markets in Eastern China, in 2016, a novel reassortant H7N6 AIV was isolated from a chicken. Phylogenetic analysis showed that this strain received its genes from H9N2, H7N9 and H5N6 AIVs infecting poultry in China. This strain showed moderate pathogenicity in mice and was able to replicate in mice without prior adaptation. Considering that this novel reassorted H7N6 virus was isolated from poultry in this study, it is possible that chickens play an important role in the generation of novel reassorted H7N6 AIVs...
January 19, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28104571/non-violent-threats-and-promises-among-closed-market-drug-dealers
#14
Timothy Dickinson
BACKGROUND: An unintended consequence of drug prohibitions is that they often fail to absolutely deter potential drug dealers and users and instead restrictively deter them. One way in which dealers sometimes alter their behaviour in response to these prohibitions is by using violent forms of social control to prevent their customers from committing careless behaviour or from becoming police informants. Many dealers, however, are reluctant to use violent forms of social control for various reasons...
January 16, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28104414/dissolution-failure-of-solid-oral-drug-products-in-field-alert-reports
#15
Dajun Sun, Meng Hu, Mark Browning, Rick L Friedman, Wenlei Jiang, Liang Zhao, Hong Wen
From 2005 to 2014, 370 data entries of dissolution failures of solid oral drug products were assessed with respect to the solubility of drug substances, dosage forms (immediate release (IR) vs. modified release (MR)), and manufacturers (brand-name vs. generic). The study results show that the solubility of drug substances does not play a significant role in dissolution failures; however, MR drug products fail dissolution tests more frequently than IR drug products. When multiple variables were analyzed simultaneously, poorly water-soluble IR drug products failed the most dissolution tests, followed by poorly soluble MR drug products and very soluble MR drug products...
January 16, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28103939/physician-migration-at-its-roots-a-study-on-the-emigration-preferences-and-plans-among-medical-students-in-romania
#16
Şoimita Mihaela Suciu, Codruta Alina Popescu, Mugur Daniel Ciumageanu, Anca Dana Buzoianu
BACKGROUND: Migration of healthcare workers is receiving increased attention worldwide. In Europe, the creation of a border-free labor market and its expansion with the EU enlargements of 2004, 2007, and 2013 endowed health professionals with the right to provide services and to relocate to another EU Member State. For the Romanian doctors, the EU-wide recognition of the medical degree obtained in Romania has created new opportunities, while inadequate working conditions and relatively low salaries pushed many of them to search for employment abroad...
January 19, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28103937/the-influence-of-marketing-on-the-sports-betting-attitudes-and-consumption-behaviours-of-young-men-implications-for-harm-reduction-and-prevention-strategies
#17
Emily G Deans, Samantha L Thomas, Jeffrey Derevensky, Mike Daube
BACKGROUND: Gambling can cause significant health and social harms for individuals, their families, and communities. While many studies have explored the individual factors that may lead to and minimise harmful gambling, there is still limited knowledge about the broader range of factors that may contribute to gambling harm. There are significant regulations to prevent the marketing of some forms of gambling but comparatively limited regulations relating to the marketing of newer forms of online gambling such as sports betting...
January 19, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28103781/prospective-clinical-applications-of-crf-peptide-antagonists
#18
Jean E Rivier
It is noteworthy that thirty three years of efforts in corticotropin releasing factor (CRF) research by academia and the pharmaceutical industry resulted in several thousand papers and patents, yet little progress has been made to identify and market diagnostic or therapeutic CRF peptides and small molecule ligands. We document the potential relevance of CRF peptide antagonists to reinvigorate stress/anxiety affected "anatomy systems" in order to boost their efficacy.
January 10, 2017: Current Molecular Pharmacology
https://www.readbyqxmd.com/read/28103416/flash-glucose-monitoring-is-associated-with-improved-glycaemic-control-but-use-is-largely-limited-to-more-affluent-people-in-a-uk-diabetes-centre
#19
J A McKnight, F W Gibb
The Freestyle Libre (Abbott Diabetes Care, Witney, UK) Flash Glucose Monitoring system was introduced in the UK in late 2014. It is not currently available on the National Health Service and is therefore marketed directly to people with diabetes. Use of the device has been associated with improvements in HbA1c in uncontrolled studies [1,2] and with reduced hypoglycaemia in a large randomized controlled trial [3]. This article is protected by copyright. All rights reserved.
January 19, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28103152/using-facebook-for-sexual-health-social-marketing-in-conservative-asian-countries-a-systematic-examination
#20
Zain-Ul-Abdin Khawaja, Khudejah Iqbal Ali, Shanze Khan
Social marketing related to sexual health is a problematic task, especially in religiously and/or culturally conservative countries. Social media presents a possible alternative channel for sexual health efforts to disseminate information and engage new users. In an effort to understand how well sexual health campaigns and organizations have leveraged this opportunity, this study presents a systematic examination of ongoing Facebook-based sexual health efforts in conservative Asian countries. It was discovered that out of hundreds of sexual health organizations identified in the region, less than half had created a Facebook page...
January 19, 2017: Journal of Health Communication
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