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https://www.readbyqxmd.com/read/28548608/a-descriptive-review-of-additional-risk-minimisation-measures-applied-to-eu-centrally-authorised-medicines-2006-2015
#1
Annalisa Rubino, Esther Artime
BACKGROUND: Guidance on therapeutic risk management, first released in EU in 2005, was updated in 2012-2013 with increased requirements on additional risk minimisation measures (aRMM). This study describes aRMM imposed at initial EU central marketing authorisation of medicines in 2006-2015. METHODS: Non-generic medicines authorised between 01/01/2006 and 31/12/2015 were identified in the European Public Assessment Report (EPAR) database. Data on aRMM, including effectiveness measures were extracted, tabulated and analysed with Excel 2016 for chi-square p value estimates and linear regression modelling as appropriate...
May 26, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28548247/market-for-artemether-lumefantrine-to-treat-childhood-malaria-in-a-district-of-southern-mozambique
#2
Sergi Alonso, Khátia Munguambe, Elisa Sicuri
Malaria is one of the leading causes of death in sub-Saharan Africa. Artemisinin-based combination therapies are used as first-line treatment drugs, but their market is far from competitive. Market failures include limited availability, low quality, lack of information, and high costs of access. We estimated the theoretical demand for one of the most common artemisinin-based combination therapies, artemether-lumefantrine (AL), and its determinants among caregivers of children with malaria seeking care at public health facilities, thus, entitled to receive drugs for free, in southern Mozambique (year 2012)...
May 26, 2017: Health Economics
https://www.readbyqxmd.com/read/28548196/-declaration-of-the-chilean-academy-of-medicine-of-law-20-850-%C3%A2-on-clinical-trials-of-pharmaceutical-products-and-medical-devices%C3%A2-and-of-the-bylaw-that-will-regulate-its-application
#3
Gloria López S, Gloria Valdés S, Emilio Roessler B, Vicente Valdivieso D
In Chile, high cost treatments required by selected medical conditions are financed by the State, according to Law 20.850. A bylaw under discussion by the Senate regulates clinical trials, posing complex issues that will endanger local interest in front-line research: 1. The exclusive and mandatory control bestowed to the Institute of Public Health during all stages of the trials and also the surveillance of institutions performing clinical trials, overriding their Clinical Research Review Boards; 2.The 10 year period during which any adverse event is assumed to have been caused by the medication or devise evaluated by the trial, unless the contrary is proven in a judicial process; 3...
March 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28547003/why-did-people-move-during-the-great-recession-the-role-of-economics-in-migration-decisions
#4
Brian L Levy, Ted Mouw, Anthony Daniel Perez
Labor migration offers an important mechanism to reallocate workers when there are regional differences in employment conditions. Whereas conventional wisdom suggests migration rates should increase during recessions as workers move out of areas that are hit hardest, initial evidence suggested that overall migration rates declined during the Great Recession, despite large regional differences in unemployment and growth rates. In this paper, we use data from the American Community Survey to analyze internal migration trends before and during the economic downturn...
April 2017: Russell Sage Foundation Journal of the Social Sciences: RSF
https://www.readbyqxmd.com/read/28546548/the-ovarian-cancer-drug-market
#5
Jennifer Bamford, Rachel M Webster
No abstract text is available yet for this article.
May 26, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28546305/national-survey-of-pharmacy-residents-nearing-completion-of-the-2014-15-residency-year
#6
Bryan M Bishop, Janet A Silvester, Christina Y Martin, Colleen G Bush
PURPOSE: The results of a national survey targeting postgraduate year 1 (PGY1) and postgraduate year 2 (PGY2) resident's perceptions of their residency programs and postresidency job prospects are presented. METHODS: An electronic survey was distributed to PGY1 and PGY2 residents identified through the ASHP membership database. The survey asked basic demographic questions, questions related to the residency experience (satisfaction, hours spent on various general activities such as patient care, research, and staffing), and various questions related to residents' job search and future career plans (search methods, outcomes, and satisfaction with the process)...
June 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28546075/antimicrobial-storage-and-antibiotic-knowledge-in-the-community-a-cross-sectional-pilot-study-in-north-western-angola
#7
Joana Cortez, Edite Rosário, João E Pires, João Taborda Lopes, Moisés Francisco, Erika Vlieghe, Miguel Brito
BACKGROUND: Antimicrobials are drugs that were once lifesavers and mainly curative. Nowadays their value is increasingly under pressure because of the fast and worldwide emergence of antimicrobial resistance, which, in low resources settings, frequently occurs in microorganisms that are likely to be transmitted in the community. METHODS: A cross-sectional pilot study including 102 households within the 10th HDSS round in Dande, Bengo Province, Angola. RESULTS: From the total 102 households piloted, 77...
May 22, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28545596/unhealthy-food-advertising-directed-to-children-on-new-zealand-television-extent-nature-impact-and-policy-implications
#8
Stefanie Vandevijvere, Alanna Soupen, Boyd Swinburn
OBJECTIVE: To comprehensively assess the extent, nature and impact of unhealthy food advertising targeted to children on New Zealand television. DESIGN: Four weekdays and four weekend days were randomly selected over the period June-August 2015. Programming was recorded from 06.00 to 00.00 hours (midnight), for a total of 432 h. Audience ratings were used to identify children's peak viewing times. SETTING: New Zealand. SUBJECTS: The three major free-to-air channels...
May 26, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28545577/proanthocyanidin-accumulation-and-transcriptional-responses-in-the-seed-coat-of-cranberry-beans-phaseolus-vulgaris-l-with-different-susceptibility-to-postharvest-darkening
#9
José A Freixas Coutin, Seth Munholland, Anjali Silva, Sanjeena Subedi, Lewis Lukens, William L Crosby, K Peter Pauls, Gale G Bozzo
BACKGROUND: Edible dry beans (Phaseolus vulgaris L.) that darken during postharvest storage are graded lower and are less marketable than their non-darkened counterparts. Seed coat darkening in susceptible genotypes is dependent upon the availability of proanthocyanidins, and their subsequent oxidation to reactive quinones. Mature cranberry beans lacking this postharvest darkening trait tend to be proanthocyanidin-deficient, although the underlying molecular and biochemical determinants for this metabolic phenomenon are unknown...
May 25, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28545354/solid-lipid-nanoparticles-approach-for-lymphatic-targeting-through-intraduodenal-delivery-of-quetiapine-fumarate
#10
Mohd Yasir, Praveen Kumar Gaur, Dinesh Puri, Preeti Shekar, S Sadish Kumar
BACKGROUND: Lymphatic route is one of the prominent route for improving the poor bioavailability of the drugs which undergoes extensive hepatic first pass metabolism. Nanocarriers (solid lipid nanoparticles) offers a new drug delivery system that could hold great promise for attaining the bioavailability enhancement along with controlled and site specific drug delivery. OBJECTIVE: The aim of the present research work was to prepare and optimized the Quetiapine fumarate (an antipsychotic drug) loaded solid lipid nanoparticles for lymphatic targeting through intraduodenal administration Method: Thirteen quetiapine fumarate loaded solid lipid nanoparticle formulations were developed using different lipids by Microemulsion technique and optimized by box behnken design...
May 25, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28545129/direct-and-indirect-costs-of-diabetes-mellitus-in-mali-a-case-control-study
#11
Clara Bermudez-Tamayo, Stéphane Besançon, Mira Johri, Sidibe Assa, Jonathan Betz Brown, Kaushik Ramaiya
BACKGROUND: Diabetes mellitus (DM) is one of the most burdensome chronic diseases and is associated with shorter lifetime, diminished quality of life and economic burdens on the patient and society as a result of healthcare, medication, and reduced labor market participation. We aimed to estimate the direct (medical and non-medical) and indirect costs of DM and compare them with those of people without DM (ND), as well as the cost predictors. METHODS AND FINDINGS: Observational retrospective case-control study performed in Mali...
2017: PloS One
https://www.readbyqxmd.com/read/28545074/influence-of-distance-between-residence-and-health-facilities-on-non-communicable-diseases-an-assessment-over-hypertension-and-diabetes-in-bangladesh
#12
Raaj Kishore Biswas, Enamul Kabir
OBJECTIVE: This paper reflected on the prevalence of hypertension and diabetes in Bangladesh, which is spreading rapidly in low-income countries. The rationale of constructing more health centers for addressing NCDs was assessed in this paper by determining the relationship between prevalence of NCDs, particularly hypertension and diabetes, and distance to health facilities. METHODS: From BDHS (Bangladesh Health and Demographic Survey) 2011 data set, 7544 samples were analyzed to demonstrate association between Non-communicable diseases (NCD) and distance from respondents' home to health facilities like hospitals, community clinics, pharmacies or doctors' chambers, and community facilities like market, post office or cinema hall...
2017: PloS One
https://www.readbyqxmd.com/read/28544939/risk-trading-in-flood-management-an-economic-model
#13
Chiung Ting Chang
Although flood management is no longer exclusively a topic of engineering, flood mitigation continues to be associated with hard engineering options. Flood adaptation or the capacity to adapt to flood risk, as well as a demand for internalizing externalities caused by flood risk between regions, complicate flood management activities. Even though integrated river basin management has long been recommended to resolve the above issues, it has proven difficult to apply widely, and sometimes even to bring into existence...
May 22, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28544553/dna-barcoding-meets-nanotechnology-development-of-a-smart-universal-tool-for-food-authentication
#14
Paola Valentini, Andrea Galimberti, Valerio Mezzasalma, Fabrizio De Mattia, Maurizio Casiraghi, Massimo Labra, Pier Paolo Pompa
Food trade globalization and the growing demand for selected food varieties have led to the intensification of adulteration cases, especially in the form of species substitution/mixing with cheaper taxa. This phenomenon acquired huge economic impact and sometimes even public health implications. DNA barcoding represents a well-proven molecular tool to assess the authenticity of food items, although its diffusion is hampered by analytical constraints and timeframes that are often prohibitive for food market...
May 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28544367/the-diverging-trajectories-of-cannabis-and-tobacco-policies-in-the-united-states-reasons-and-possible-implications
#15
Wayne Hall, Lynn T Kozlowski
AIM: To examine briefly the (i) rationales for two policy proposals in the United States to make it mandatory for cigarettes to contain very low levels of nicotine and to legalize cannabis for recreational use by adults; and (ii) possible lessons that participants in each policy debate may learn from each other. METHOD: We briefly describe the diverging policies towards cannabis and tobacco in the United States, explain and critically analyse their rationales and discuss possible policy lessons...
May 22, 2017: Addiction
https://www.readbyqxmd.com/read/28544093/adolescents-exposure-to-paid-alcohol-advertising-on-television-and-their-alcohol-use-exploring-associations-over-a-13-year-period
#16
V White, D Azar, A Faulkner, K Coomber, S Durkin, M Livingston, T Chikritzhs, R Room, M Wakefield
AIMS: To determine i) whether Australian adolescents' exposure to television alcohol advertisements changed between 1999 and 2011 and ii) examine the association between television alcohol advertising and adolescent drinking behaviours. DESIGN: Cross-sectional surveys conducted every three years between 1999 and 2011. Analyses examined associations between advertising exposures and reported drinking. SETTING: Five Australian major cities. PARTICIPANTS: Students aged 12-17 years participating in a triennial nationally representative school-based survey residing in the television advertising markets associated with the major cities (sample size range per survey: 12644 to 16004)...
May 20, 2017: Addiction
https://www.readbyqxmd.com/read/28543423/research-with-pregnant-women-new-insights-on-legal-decision-making
#17
Anna C Mastroianni, Leslie Meltzer Henry, David Robinson, Theodore Bailey, Ruth R Faden, Margaret O Little, Anne Drapkin Lyerly
U.S. researchers and scholars often point to two legal factors as significant obstacles to the inclusion of pregnant women in clinical research: the Department of Health and Human Services' regulatory limitations specific to pregnant women's research participation and the fear of liability for potential harm to children born following a pregnant woman's research participation. This article offers a more nuanced view of the potential legal complexities that can impede research with pregnant women than has previously been reflected in the literature...
May 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28543033/cereal-bars-produced-with-banana-peel-flour-evaluation-of-acceptability-and-sensory-profile
#18
Vania Silva Carvalho, Ana Carolina Conti-Silva
BACKGROUND: A Mixture design was used to investigate the effects of banana peel flour, rice flakes and oat flour on sensory acceptability of cereal bars, with subsequent evaluation of sensory profile of products identified as having high acceptability. RESULTS: Regions of greater response for acceptability of the cereal bars, which are dependent on the three investigated components, were found. Although having good acceptability, sensory profiles of cereal bars were different...
May 25, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28542630/dose-dependent-effect-of-silver-nanoparticles-agnps-on-fertility-and-survival-of-drosophila-an-in-vivo-study
#19
Akanksha Raj, Prasanna Shah, Namita Agrawal
Silver nanoparticles (AgNPs) containing consumer products have been proliferating in the market due to its unique antimicrobial property, however, lack of in-depth knowledge about their potential effect on human health in a longer run is of great concern. Therefore, we investigated dose-dependent in vivo effect of AgNPs using Drosophila as a model system. Drosophila, a genetically tractable organism with distinct developmental stages, short life cycle and significant homology with human serves as an ideal organism to study nanomaterial-mediated toxicity...
2017: PloS One
https://www.readbyqxmd.com/read/28542349/crispr-cas9-mediated-targeted-mutagenesis-in-grape
#20
Ikuko Nakajima, Yusuke Ban, Akifumi Azuma, Noriyuki Onoue, Takaya Moriguchi, Toshiya Yamamoto, Seiichi Toki, Masaki Endo
RNA-guided genome editing using the CRISPR/Cas9 CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated protein 9) system has been applied successfully in several plant species. However, to date, there are few reports on the use of any of the current genome editing approaches in grape-an important fruit crop with a large market not only for table grapes but also for wine. Here, we report successful targeted mutagenesis in grape (Vitis vinifera L., cv. Neo Muscat) using the CRISPR/Cas9 system...
2017: PloS One
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