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pseudothrombocytopenia

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https://www.readbyqxmd.com/read/29739084/double-whammy-of-thrombocytopenia-a-case-of-temperature-and-edta-dependent-pseudothrombocytopenia
#1
Li Yang, Hemant Goyal, Gao-Ming Zhang, Guo-Ming Zhang
No abstract text is available yet for this article.
April 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29727871/-thrombocytopenia-in-horses
#2
Emma Hübers, Natali Bauer, Kerstin Fey, Andreas Moritz, Katja Roscher
OBJECTIVE: The retrospective study aimed to evaluate the prevalence of true thrombocytopenia and ethylenediaminetetraacetic acid (EDTA)-induced pseudothrombocytopenia in horses and ponies and to assess the diagnostic and prognostic utility of true thrombocytopenia. MATERIAL AND METHODS: In 3592 patients (2008-2015) hematological data (ADVIA® 2120, Siemens) were reviewed. Inclusion criteria were platelet counts < 90 x 109/l (EDTA-blood) and/or < 84 x 109/l (citrate blood)...
April 2018: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/29512619/a-practical-and-case-based-approach-to-thrombocytopenia-in-cardiology-practice
#3
Erman Öztürk, Ferit Onur Mutluer
In cardiology practice, anticoagulation and antiplatelet therapies are essential for most patients. As of yet, there is no high quality evidence regarding these treatments in thrombocytopenic patients, which continues to be an issue. Thrombocytopenia is defined as a platelet count of <150x109/L and is classified as severe when the platelet count is <50x109/L. Pseudothrombocytopenia, drug-induced thrombocytopenia, immune thrombocytopenia, heparin-induced thrombocytopenia, and thrombotic thrombocytopenic purpura are some of the main causes of thrombocytopenia...
March 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29341241/pan-pseudothrombocytopenia-an-unusual-case-of-platelet-clumping
#4
Hany Elmariah, Satish Shanbhag
No abstract text is available yet for this article.
January 17, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29145678/-thrombocytosis-and-thrombocytopenia-background-and-clinical-relevance
#5
REVIEW
Kai Wille, Parvis Sadjadian, Martin Griesshammer
Due to the central role of platelets in hemostasis, the clinical relevance of quantitative changes in platelet counts (< 150 G/l or > 450 G/l) may be significant. Thrombopoesis (= production of platelets) occurs in the bone marrow, and the hormone thrombopoetin takes control on its regulation.In thrombocytosis, primary causes have to be distinguished from the far more common reactive (= secondary) reasons. The most important form of primary thrombocytosis occurs in myeloproliferative neoplasms especially in essential thrombocythemia (ET)...
November 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28751293/a-case-report-of-pseudo-grey-platelet-syndrome-with-citrate-induced-pseudothrombocytopenia-those-artifacts-may-interfere-in-the-platelet-numeration-and-lead-to-critical-misdiagnosis
#6
Agathe Herb, Maxime Maurer, Isabelle Alamome, Pierre-Adrien Bihl, Cosmina Ghiura, Rémy Hurstel
The pseudo grey platelet syndrome is a rare artifact due to the degranulation of platelets caused, in vitro, by EDTA. This phenomenon is likely to disturb the platelet numeration and it is essential not to mistake it for a grey syndrome platelet, which is a constitutional thrombopathy with macrothrombopenia, in order to avoid specialized tests, or even misdiagnosis. Indeed, these two entities are cytologically alike, as grey platelets are found on the blood smear of a sample collected on EDTA in both cases...
August 1, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/28710245/abciximab-induced-acute-profound-thrombocytopenia-postpercutaneous-coronary-intervention
#7
Todd Golden, Sehem Ghazala, Rita Wadeea, Shilpa Junna
Abciximab (c7E3 Fab) is one of the three potent intravenous glycoprotein IIb/IIIa receptor inhibitors (along with eptifibatide and tirofiban) that have shown significant positive outcomes when used in patients with intracoronary thrombus. However, major side effects have been reported with its use including hypotension, major bleeding and thrombocytopenia. This case is a 53-year-old man presenting with acute chest pain diagnosed with non-ST-elevation myocardial infarction, who underwent percutaneous coronary intervention with abciximab and heparin infusion and developed acute profound thrombocytopenia (platelet count <20,000/L) within 9 hours of infusion...
July 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28619392/platelet-satellitism-in-autoimmune-hemolytic-anemia
#8
REVIEW
I Ghariani, N Braham, S Hamzaoui, L Bekir
Platelet satellitism is a rare phenomenon observed in blood smears obtained from blood anticoagulated with EDTA with an estimated frequency at 0.008%. It is characterized by platelet rosetting around neutrophils and in rare cases around other blood cells, which may causes pseudothrombocytopenia. Our case involves a 26-year-old female patient with autoimmune hemolytic anemia (AIHA). Blood smear with EDTA as an anticoagulant had platelet satellitism whereas the phenomenon was not observed in tubes with different anticoagulants (citrate, heparin) and capillary blood...
April 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/28582600/effect-of-time-and-temperature-on-anticoagulant-dependent-pseudothrombocytopenia-in-g%C3%A3-ttingen-minipigs
#9
Tim Erkens, Liesbeth Van den Sande, Jill Witters, Filip Verbraeken, Adriana Looszova, Bianca Feyen
BACKGROUND: A marked decrease in thrombocyte count was observed between subsequent measurements of the same EDTA blood sample in several minipigs, but little information was available explaining this finding. OBJECTIVES: The objective was to evaluate the impact of several preanalytic variables on thrombocyte counts in minipigs, in order to improve understanding of the in vitro thrombocyte decrease observed. MATERIALS AND METHODS: Hematology blood samples from male and female Göttingen minipigs were collected using EDTA or citrate as an anticoagulant...
September 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28579856/estimation-of-platelet-counts-and-other-hematological-parameters-in-pseudothrombocytopenia-using-alternative-anticoagulant-magnesium-sulfate
#10
REVIEW
Chidambharam Choccalingam, Rajesh Kanna Nandagopal Radha, Nadella Snigdha
The platelet count, mean platelet volume, and other hematological parameters were compared in blood samples anticoagulated with MgSO4 and EDTA. A total of 15 samples were taken, and the platelet counts were observed to be significantly high in MgSO4-anticoagulated blood samples ranging from 53 × 10(3) to 499 × 10(3)/μL, whereas in EDTA-anticoagulated blood samples, the counts ranged from 10 × 10(3) to 353 × 10(3)/μL. This increased platelet count was also statistically significant with the P value being ...
2017: Clinical Medicine Insights. Blood Disorders
https://www.readbyqxmd.com/read/28491219/-a-non-edta-dependent-pseudothrombocytopenia-about-a-case
#11
Hicham Titou, Youssef Jalal, Mohammed Boui
Pseudothrombocytopenia is a rare phenomenon in laboratory explained by in vitro agglutination of platelets. Microscopic examination of the peripheral blood smear is of key importance to confirm the diagnosis and to avoid any inappropriate or dangerous clinical and therapeutic decision. Its occurrence in a patient, under treatment with heparin, raises the problem of differential diagnosis of heparin-induced thrombocytopenia. The aim of this study was to eliminate any confusion between this purely artefactual phenomenon and heparin-induced thrombocytopenia...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28296756/transient-appearance-of-edta-dependent-pseudothrombocytopenia-in-a-postoperative-patient-with-sepsis-a-case-report
#12
Xiang Shi, Zhongyuan Lin, Liyan He, Wenchao Li, Lijun Mo, Yinyin Li, Zheng Yang, Wu-Ning Mo
RATIONALE: Ethylenediaminetetraacetic acid-dependent pseudothrombocytopenia (EDTA-PTCP) is a rare phenomenon characterized by spuriously low platelet counts when EDTA reacts with harvested blood. However, to the best of our knowledge, only two cases involving EDTA-PTCP in postoperative patients with sepsis have been reported. Here, we describe a case of EDTA-PTCP that appeared transiently in a postoperative patient with sepsis. PATIENT CONCERNS: A 68-year-old female patient underwent laparoscopic tension-free hernioplasty for incisional hernia...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28180009/pseudothrombocytopenia-with-multiple-anticoagulant-sample-collection-tubes
#13
REVIEW
Ferenc Kovacs, Marina Varga, Zsolt Pataki, Erzsebet Rigo
The knowledge of pseudothrombocytopenia (PTCP) is important for the accuracy of a clinical assessment and for avoiding unnecessary treatment. An elderly patient was hospitalized with left lung pneumonia. Severe thrombocytopenia [platelet (PLT) number: 18 × 10(9)/L] without any clinical bleeding was found in ethylenediaminetetraacetic acid blood collection tube. PLT measurement was repeated in various anticoagulant [sodium citrate, lithium heparin, disodium oxalate, hirudin, and magnesium sulfate (Mg-sulfate)] sample collection tubes and all of them showed thrombocytopenia except with Mg-sulfate...
December 2016: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/28034871/how-i-evaluate-and-treat-thrombocytopenia-in-the-intensive-care-unit-patient
#14
Andreas Greinacher, Sixten Selleng
Multiple causes (pseudothrombocytopenia, hemodilution, increased consumption, decreased production, increased sequestration, and immune-mediated destruction of platelets) alone or in combination make thrombocytopenia very common in intensive care unit (ICU) patients. Persisting thrombocytopenia in critically ill patients is associated with, but not causative of, increased mortality. Identification of the underlying cause is key for management decisions in individual patients. While platelet transfusion might be indicated in patients with impaired platelet production or increased platelet destruction, it could be deleterious in patients with increased intravascular platelet activation...
December 29, 2016: Blood
https://www.readbyqxmd.com/read/27866576/thrombocytopenia
#15
REVIEW
Eun-Ju Lee, Alfred Ian Lee
Thrombocytopenia is a commonly encountered hematologic problem in inpatient and ambulatory medicine. The many underlying mechanisms of thrombocytopenia include pseudothrombocytopenia, splenic sequestration, and marrow underproduction and destruction. This article presents the known causes of thrombocytopenia, a framework for evaluation, and brief descriptions of management in a case-based format.
December 2016: Primary Care
https://www.readbyqxmd.com/read/27852074/impact-of-amikacin-on-pseudothrombocytopenia
#16
Payman Baradar Bokaei, Daniel Grabovsky, Nadine Shehata, Chen Wang
No abstract text is available yet for this article.
2017: Acta Haematologica
https://www.readbyqxmd.com/read/27737843/shreiner-dp-bell-wr-pseudothrombocytopenia-manifestation-of-a-new-type-of-platelet-agglutinin-blood-1973-42-4-541-549
#17
(no author information available yet)
No abstract text is available yet for this article.
October 13, 2016: Blood
https://www.readbyqxmd.com/read/27708967/ethylenediaminetetraacetic-acid-dependent-pseudothrombocytopenia-in-a-patient-with-systemic-lupus-erythematosus-and-lupus-nephritis
#18
Lütfi Akyol, Soner Önem, Metin Özgen, Mehmet Sayarlıoğlu
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by several immunological abnormalities. We wish to communicate the case of a patient with SLE and lupus nephritis (LN) who developed pseudothrombocytopenia. Pseudothrombocytopenia can occur in patients with SLE and LN and should be considered when diagnosing patients with thrombocytopenia without bleeding.
March 2016: European Journal of Rheumatology
https://www.readbyqxmd.com/read/27391303/effect-of-prewarming-edta-blood-samples-to-37%C3%A2-c-on-platelet-count-measured-by-sysmex-xt-2000iv-in-dogs-cats-and-horses
#19
Tim L Williams, Joy Archer
BACKGROUND: Pseudothrombocytopenia secondary to platelet clumping is a common cause of preanalytic error for platelet counts in dogs, cats, and horses. In human beings, it is suggested that prewarming blood samples to 37°C prior to hematology analysis will reduce platelet clumping. OBJECTIVES: The purpose of the study was to evaluate the effect of prewarming EDTA blood samples to 37°C on measured platelet counts and other hematologic variables. METHODS: The EDTA blood samples from dogs, cats and horses submitted to the clinical pathology laboratory at the University of Cambridge were included...
September 2016: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/27215777/thrombocytopenia-pitfalls-misdiagnosing-type-2b-von-willebrand-disease-as-ethylenediaminetetraacetic-acid-dependent-pseudothrombocytopenia
#20
Riten Kumar, Susan Creary, Elizabeth A Varga, Samir B Kahwash
No abstract text is available yet for this article.
August 2016: Journal of Pediatrics
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