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October 13, 2016: Blood
Lütfi Akyol, Soner Önem, Metin Özgen, Mehmet Sayarlıoğlu
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by several immunological abnormalities. We wish to communicate the case of a patient with SLE and lupus nephritis (LN) who developed pseudothrombocytopenia. Pseudothrombocytopenia can occur in patients with SLE and LN and should be considered when diagnosing patients with thrombocytopenia without bleeding.
March 2016: Eur J Rheumatol
Tim L Williams, Joy Archer
BACKGROUND: Pseudothrombocytopenia secondary to platelet clumping is a common cause of preanalytic error for platelet counts in dogs, cats, and horses. In human beings, it is suggested that prewarming blood samples to 37°C prior to hematology analysis will reduce platelet clumping. OBJECTIVES: The purpose of the study was to evaluate the effect of prewarming EDTA blood samples to 37°C on measured platelet counts and other hematologic variables. METHODS: The EDTA blood samples from dogs, cats and horses submitted to the clinical pathology laboratory at the University of Cambridge were included...
September 2016: Veterinary Clinical Pathology
Riten Kumar, Susan Creary, Elizabeth A Varga, Samir B Kahwash
No abstract text is available yet for this article.
August 2016: Journal of Pediatrics
Satoko Noguchi, Masato Kitayama, Hidetomo Niwa, Yoshiko Tamai, Kazuyoshi Hirota
We experienced an unexpected thrombocytopenia detected only in vitro during radical prostatectomy for a 66-year-old patient. Thrombocytopenia with platelet aggregation was observed in a blood sample obtained using a heparinized syringe (not by ethylene diamine tetra-acetic acid tube). Although we could not exclude platelet agglutination in vivo, no thrombosis or coagulation disorder was observed. We changed the anti-coagulant in the arterial catheter carrier fluid (saline) from heparin to argatroban, and continued with the operation...
August 2016: Journal of Anesthesia
Riitta Lassila
Functional disorders of platelets can involve any aspect of platelet physiology, with many different effects or outcomes. These include platelet numbers (thrombocytosis or thrombocytopenia); changes in platelet production or destruction, or capture to the liver (Ashwell receptor); altered adhesion to vascular injury sites and/or influence on hemostasis and wound healing; and altered activation or receptor functions, shape change, spreading and release reactions, procoagulant and antifibrinolytic activity. Procoagulant membrane alterations, and generation of thrombin and fibrin, also affect platelet aggregation...
April 2016: Seminars in Thrombosis and Hemostasis
Barbara Riond, Andrea Katharina Waßmuth, Sonja Hartnack, Regina Hofmann-Lehmann, Hans Lutz
BACKGROUND: Feline platelets are prone to clumping after blood collection, rendering the determination of accurate platelet counts difficult for clinical laboratories and resulting in a high incidence of pseudothrombocytopenia in feline haematology reports. No information is available about the kinetics of platelet aggregate formation in feline ethylenediaminetetraacetic acid blood and the course of platelet counts over a clinically relevant time period. The aim of the present study was to determine platelet counts in healthy cats over a time period of 24 h after blood collection at 9 time points; to assess potential effects of platelet aggregates, anaesthesia and bleeding conditions on feline platelets and white blood cell counts; and finally, to investigate if glucose concentration is associated with the presence of aggregates...
2015: BMC Veterinary Research
Yang Jiao, Ruihua Mi, Bing Liu, Xiaoxian Lyu
No abstract text is available yet for this article.
September 2015: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
Barbara Riond, Andrea Katharina Waßmuth, Sonja Hartnack, Regina Hofmann-Lehmann, Hans Lutz
BACKGROUND: In vitro platelet aggregation in feline blood samples is a well-known phenomenon in veterinary clinical laboratories resulting in high numbers of pseudothrombocytopenia. Several attempts have been made to prevent or dissolve platelet aggregates in feline blood samples and to increase the reliability of feline platelet counts. Prostaglandin I2 (PGI2) is the most powerful endogenous inhibitor of platelet aggregation but unstable. Iloprost is a stable PGI2 analogue. The aims of the present study were (1) to evaluate the anti-aggregatory effect of Iloprost on feline platelet counts and to determine a useful concentration to inhibit platelet aggregation in EDTA samples from clinically healthy cats, (2) to investigate the effect of Iloprost on hematological blood parameters, and (3) to determine stability of Iloprost in K3-EDTA tubes for up to 16 weeks...
2015: BMC Veterinary Research
Uğur Canpolat, Mehmet Kadri Akboga
No abstract text is available yet for this article.
January 2016: Angiology
Gökhan Çiçek, Çağrı Yayla, Sadık Kadri Açıkgoz
No abstract text is available yet for this article.
January 2016: Angiology
Ali Ugur Uslu, Satılmıs Inal, Sevket Balta
No abstract text is available yet for this article.
January 2016: Angiology
Valentina Vidranski, Renata Laskaj, Dubravka Sikiric, Visnja Skerk
BACKGROUND: Platelet satellitism is a phenomenon of unknown etiology of aggregating platelets around polymorphonuclear neutrophils and other blood cells which causes pseudothrombocytopenia, visible by microscopic examination of blood smears. It has been observed so far in about a hundred cases in the world. CASE SUBJECT AND METHODS: Our case involves a 73-year-old female patient with a urinary infection. Biochemical serum analysis (CRP, glucose, AST, ALT, ALP, GGT, bilirubin, sodium, potassium, chloride, urea, creatinine) and blood cell count were performed with standard methods on autoanalyzers...
2015: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
Yufei Xiao, Shuihong Yu, Yang Xu
No abstract text is available yet for this article.
2015: Acta Haematologica
I M Sánchez Guiu, I Martínez-Martinez, C Martínez, J Navarro-Fernandez, F García-Candel, F Ferrer-Marín, V Vicente, S P Watson, R K Andrews, E E Gardiner, M L Lozano, J Rivera
Platelet cold agglutinins (PCA) cause pseudothrombocytopenia, spurious thrombocytopenia due to ex vivo platelet clumping, complicating clinical diagnosis, but mechanisms and consequences of PCA are not well defined. Here, we characterised an atypical immunoglobulin (Ig)M PCA in a 37-year-old woman with lifelong bleeding and chronic moderate thrombocytopenia, that induces activation and aggregation of autologous or allogeneic platelets via interaction with platelet glycoprotein (GP)VI. Patient temperature-dependent pseudothrombocytopenia was EDTA-independent, but was prevented by integrin αIIbβ3 blockade...
August 2015: Thrombosis and Haemostasis
Naoko Ohashi-Fukuda, Ryota Inokuchi, Hajime Sato, Kensuke Nakamura, Masao Iwagami, Tomoki Wada, Masahiro Jona, Takashi Hisasue, Susumu Nakajima, Naoki Yahagi
In ethylenediaminetetraacetic acid (EDTA)-dependent pseudothrombocytopenia (PTCP), automated platelet counts are lower than actual counts because of EDTA-induced aggregation. Factors contributing to the incidence of EDTA-PTCP are unknown, and no study has assessed the prognosis of EDTA-PTCP patients. This retrospective study assessed characteristics in EDTA-PTCP patients and matched controls to determine differences in prognosis. A retrospective case-control study was designed. From the University of Tokyo Hospital database, we identified patients diagnosed with EDTA-PTCP between 2009 and 2012, and performed 1:2 case:control matching for age and sex...
April 2015: Medicine (Baltimore)
Izhar Shabnam, Chuphal D S, Joshi B C
No abstract text is available yet for this article.
October 2014: Journal of Clinical and Diagnostic Research: JCDR
Jianhua Lin, Yaoling Luo, Shaoyu Yao, Miansheng Yan, Jianpei Li, Wenting Ouyang, Miaohuan Kuang
BACKGROUND: Ethylene diamine tetraacetic acid dependent pseudothrombocytopenia (EDTA-PTCP) is a laboratory artifact that may lead to unnecessary evaluation and treatment of patients. The purpose of this article is to discuss how to identify EDTA-PTCP and correct spurious low platelet counts in clinical laboratories. METHODS: We use two criteria to screen for platelet aggregation: (1) an abnormal platelet count in EDTA-treated blood from a patient lacking clinical signs of a platelet disorder, and (2) an instrument flag for platelet clumps...
September 2015: Journal of Clinical Laboratory Analysis
Wei-Yu Mao, Mei Huo, Su-Dan Ye, Wen-Bo Gong
The purpose of this study was to investigate the incidence of clinically common EDTA-dependent pseudo-thrombocytopenia (EDTA-PTCP) and methols for treating this diseese. A total of 1326 cases of thrombocytopenia found at blood routine examination were amalyzed anong 71 535 patients hospitalized in our hospital from January 2010 to May 2013, and 87 cases of PTCP caused EDTA-K anticoagulant were analyzed again by using sodium citrate auticoagulant, at the same time the platelet formation distribution was observed by microscopy of smear with Wright-Giemsa staining...
October 2014: Zhongguo Shi Yan Xue Ye Xue za Zhi
Yufei Xiao, Yang Xu
The proportion and potential risk of concomitant spuriously elevated white blood cell count (SEWC) are underestimated in ethylenediaminetetraacetic acid (EDTA)-dependent pseudothrombocytopenia (PTCP). The proportion, kinetics and prevention of SEWC remain poorly understood. A total of 25 patients with EDTA-dependent PTCP were enrolled in this study. With the hematology analyzer Coulter LH 750, we determined the time courses of WBC count, WBC differential and platelet count in EDTA- and sodium citrate-anticoagulated blood, respectively...
2015: Platelets
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