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pseudothrombocytopenia

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https://www.readbyqxmd.com/read/28710245/abciximab-induced-acute-profound-thrombocytopenia-postpercutaneous-coronary-intervention
#1
Todd Golden, Sehem Ghazala, Rita Wadeea, Shilpa Junna
Abciximab (c7E3 Fab) is one of the three potent intravenous glycoprotein IIb/IIIa receptor inhibitors (along with eptifibatide and tirofiban) that have shown significant positive outcomes when used in patients with intracoronary thrombus. However, major side effects have been reported with its use including hypotension, major bleeding and thrombocytopenia. This case is a 53-year-old man presenting with acute chest pain diagnosed with non-ST-elevation myocardial infarction, who underwent percutaneous coronary intervention with abciximab and heparin infusion and developed acute profound thrombocytopenia (platelet count <20,000/L) within 9 hours of infusion...
July 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28619392/platelet-satellitism-in-autoimmune-hemolytic-anemia
#2
REVIEW
I Ghariani, N Braham, S Hamzaoui, L Bekir
Platelet satellitism is a rare phenomenon observed in blood smears obtained from blood anticoagulated with EDTA with an estimated frequency at 0.008%. It is characterized by platelet rosetting around neutrophils and in rare cases around other blood cells, which may causes pseudothrombocytopenia. Our case involves a 26-year-old female patient with autoimmune hemolytic anemia (AIHA). Blood smear with EDTA as an anticoagulant had platelet satellitism whereas the phenomenon was not observed in tubes with different anticoagulants (citrate, heparin) and capillary blood...
June 12, 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/28582600/effect-of-time-and-temperature-on-anticoagulant-dependent-pseudothrombocytopenia-in-g%C3%A3-ttingen-minipigs
#3
Tim Erkens, Liesbeth Van den Sande, Jill Witters, Filip Verbraeken, Adriana Looszova, Bianca Feyen
BACKGROUND: A marked decrease in thrombocyte count was observed between subsequent measurements of the same EDTA blood sample in several minipigs, but little information was available explaining this finding. OBJECTIVES: The objective was to evaluate the impact of several preanalytic variables on thrombocyte counts in minipigs, in order to improve understanding of the in vitro thrombocyte decrease observed. MATERIALS AND METHODS: Hematology blood samples from male and female Göttingen minipigs were collected using EDTA or citrate as an anticoagulant...
June 5, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28579856/estimation-of-platelet-counts-and-other-hematological-parameters-in-pseudothrombocytopenia-using-alternative-anticoagulant-magnesium-sulfate
#4
REVIEW
Chidambharam Choccalingam, Rajesh Kanna Nandagopal Radha, Nadella Snigdha
The platelet count, mean platelet volume, and other hematological parameters were compared in blood samples anticoagulated with MgSO4 and EDTA. A total of 15 samples were taken, and the platelet counts were observed to be significantly high in MgSO4-anticoagulated blood samples ranging from 53 × 10(3) to 499 × 10(3)/μL, whereas in EDTA-anticoagulated blood samples, the counts ranged from 10 × 10(3) to 353 × 10(3)/μL. This increased platelet count was also statistically significant with the P value being ...
2017: Clinical Medicine Insights. Blood Disorders
https://www.readbyqxmd.com/read/28491219/-a-non-edta-dependent-pseudothrombocytopenia-about-a-case
#5
Hicham Titou, Youssef Jalal, Mohammed Boui
Pseudothrombocytopenia is a rare phenomenon in laboratory explained by in vitro agglutination of platelets. Microscopic examination of the peripheral blood smear is of key importance to confirm the diagnosis and to avoid any inappropriate or dangerous clinical and therapeutic decision. Its occurrence in a patient, under treatment with heparin, raises the problem of differential diagnosis of heparin-induced thrombocytopenia. The aim of this study was to eliminate any confusion between this purely artefactual phenomenon and heparin-induced thrombocytopenia...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28296756/transient-appearance-of-edta-dependent-pseudothrombocytopenia-in-a-postoperative-patient-with-sepsis-a-case-report
#6
Xiang Shi, Zhongyuan Lin, Liyan He, Wenchao Li, Lijun Mo, Yinyin Li, Zheng Yang, Wu-Ning Mo
RATIONALE: Ethylenediaminetetraacetic acid-dependent pseudothrombocytopenia (EDTA-PTCP) is a rare phenomenon characterized by spuriously low platelet counts when EDTA reacts with harvested blood. However, to the best of our knowledge, only two cases involving EDTA-PTCP in postoperative patients with sepsis have been reported. Here, we describe a case of EDTA-PTCP that appeared transiently in a postoperative patient with sepsis. PATIENT CONCERNS: A 68-year-old female patient underwent laparoscopic tension-free hernioplasty for incisional hernia...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28180009/pseudothrombocytopenia-with-multiple-anticoagulant-sample-collection-tubes
#7
REVIEW
Ferenc Kovacs, Marina Varga, Zsolt Pataki, Erzsebet Rigo
The knowledge of pseudothrombocytopenia (PTCP) is important for the accuracy of a clinical assessment and for avoiding unnecessary treatment. An elderly patient was hospitalized with left lung pneumonia. Severe thrombocytopenia [platelet (PLT) number: 18 × 10(9)/L] without any clinical bleeding was found in ethylenediaminetetraacetic acid blood collection tube. PLT measurement was repeated in various anticoagulant [sodium citrate, lithium heparin, disodium oxalate, hirudin, and magnesium sulfate (Mg-sulfate)] sample collection tubes and all of them showed thrombocytopenia except with Mg-sulfate...
December 2016: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/28034871/how-i-evaluate-and-treat-thrombocytopenia-in-the-intensive-care-unit-patient
#8
REVIEW
Andreas Greinacher, Sixten Selleng
Multiple causes (pseudothrombocytopenia, hemodilution, increased consumption, decreased production, increased sequestration, and immune-mediated destruction of platelets) alone or in combination make thrombocytopenia very common in intensive care unit (ICU) patients. Persisting thrombocytopenia in critically ill patients is associated with, but not causative of, increased mortality. Identification of the underlying cause is key for management decisions in individual patients. While platelet transfusion might be indicated in patients with impaired platelet production or increased platelet destruction, it could be deleterious in patients with increased intravascular platelet activation...
December 29, 2016: Blood
https://www.readbyqxmd.com/read/27866576/thrombocytopenia
#9
REVIEW
Eun-Ju Lee, Alfred Ian Lee
Thrombocytopenia is a commonly encountered hematologic problem in inpatient and ambulatory medicine. The many underlying mechanisms of thrombocytopenia include pseudothrombocytopenia, splenic sequestration, and marrow underproduction and destruction. This article presents the known causes of thrombocytopenia, a framework for evaluation, and brief descriptions of management in a case-based format.
December 2016: Primary Care
https://www.readbyqxmd.com/read/27852074/impact-of-amikacin-on-pseudothrombocytopenia
#10
Payman Baradar Bokaei, Daniel Grabovsky, Nadine Shehata, Chen Wang
No abstract text is available yet for this article.
2017: Acta Haematologica
https://www.readbyqxmd.com/read/27737843/shreiner-dp-bell-wr-pseudothrombocytopenia-manifestation-of-a-new-type-of-platelet-agglutinin-blood-1973-42-4-541-549
#11
(no author information available yet)
No abstract text is available yet for this article.
October 13, 2016: Blood
https://www.readbyqxmd.com/read/27708967/ethylenediaminetetraacetic-acid-dependent-pseudothrombocytopenia-in-a-patient-with-systemic-lupus-erythematosus-and-lupus-nephritis
#12
Lütfi Akyol, Soner Önem, Metin Özgen, Mehmet Sayarlıoğlu
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by several immunological abnormalities. We wish to communicate the case of a patient with SLE and lupus nephritis (LN) who developed pseudothrombocytopenia. Pseudothrombocytopenia can occur in patients with SLE and LN and should be considered when diagnosing patients with thrombocytopenia without bleeding.
March 2016: European Journal of Rheumatology
https://www.readbyqxmd.com/read/27391303/effect-of-prewarming-edta-blood-samples-to-37%C3%A2-c-on-platelet-count-measured-by-sysmex-xt-2000iv-in-dogs-cats-and-horses
#13
Tim L Williams, Joy Archer
BACKGROUND: Pseudothrombocytopenia secondary to platelet clumping is a common cause of preanalytic error for platelet counts in dogs, cats, and horses. In human beings, it is suggested that prewarming blood samples to 37°C prior to hematology analysis will reduce platelet clumping. OBJECTIVES: The purpose of the study was to evaluate the effect of prewarming EDTA blood samples to 37°C on measured platelet counts and other hematologic variables. METHODS: The EDTA blood samples from dogs, cats and horses submitted to the clinical pathology laboratory at the University of Cambridge were included...
September 2016: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/27215777/thrombocytopenia-pitfalls-misdiagnosing-type-2b-von-willebrand-disease-as-ethylenediaminetetraacetic-acid-dependent-pseudothrombocytopenia
#14
Riten Kumar, Susan Creary, Elizabeth A Varga, Samir B Kahwash
No abstract text is available yet for this article.
August 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27142615/a-case-report-of-sudden-thrombocytopenia-detected-only-by-in-vitro-analysis
#15
Satoko Noguchi, Masato Kitayama, Hidetomo Niwa, Yoshiko Tamai, Kazuyoshi Hirota
We experienced an unexpected thrombocytopenia detected only in vitro during radical prostatectomy for a 66-year-old patient. Thrombocytopenia with platelet aggregation was observed in a blood sample obtained using a heparinized syringe (not by ethylene diamine tetra-acetic acid tube). Although we could not exclude platelet agglutination in vivo, no thrombosis or coagulation disorder was observed. We changed the anti-coagulant in the arterial catheter carrier fluid (saline) from heparin to argatroban, and continued with the operation...
August 2016: Journal of Anesthesia
https://www.readbyqxmd.com/read/26886396/platelet-function-tests-in-bleeding-disorders
#16
REVIEW
Riitta Lassila
Functional disorders of platelets can involve any aspect of platelet physiology, with many different effects or outcomes. These include platelet numbers (thrombocytosis or thrombocytopenia); changes in platelet production or destruction, or capture to the liver (Ashwell receptor); altered adhesion to vascular injury sites and/or influence on hemostasis and wound healing; and altered activation or receptor functions, shape change, spreading and release reactions, procoagulant and antifibrinolytic activity. Procoagulant membrane alterations, and generation of thrombin and fibrin, also affect platelet aggregation...
April 2016: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/26542105/study-on-the-kinetics-and-influence-of-feline-platelet-aggregation-and-deaggregation
#17
Barbara Riond, Andrea Katharina Waßmuth, Sonja Hartnack, Regina Hofmann-Lehmann, Hans Lutz
BACKGROUND: Feline platelets are prone to clumping after blood collection, rendering the determination of accurate platelet counts difficult for clinical laboratories and resulting in a high incidence of pseudothrombocytopenia in feline haematology reports. No information is available about the kinetics of platelet aggregate formation in feline ethylenediaminetetraacetic acid blood and the course of platelet counts over a clinically relevant time period. The aim of the present study was to determine platelet counts in healthy cats over a time period of 24 h after blood collection at 9 time points; to assess potential effects of platelet aggregates, anaesthesia and bleeding conditions on feline platelets and white blood cell counts; and finally, to investigate if glucose concentration is associated with the presence of aggregates...
2015: BMC Veterinary Research
https://www.readbyqxmd.com/read/26462783/-pseudothrombocytopenia-induced-by-a-variety-of-anticoagulants-a-case-report-and-literatures-review
#18
REVIEW
Yang Jiao, Ruihua Mi, Bing Liu, Xiaoxian Lyu
No abstract text is available yet for this article.
September 2015: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/26245701/effective-prevention-of-pseudothrombocytopenia-in-feline-blood-samples-with-the-prostaglandin-i2-analogue-iloprost
#19
Barbara Riond, Andrea Katharina Waßmuth, Sonja Hartnack, Regina Hofmann-Lehmann, Hans Lutz
BACKGROUND: In vitro platelet aggregation in feline blood samples is a well-known phenomenon in veterinary clinical laboratories resulting in high numbers of pseudothrombocytopenia. Several attempts have been made to prevent or dissolve platelet aggregates in feline blood samples and to increase the reliability of feline platelet counts. Prostaglandin I2 (PGI2) is the most powerful endogenous inhibitor of platelet aggregation but unstable. Iloprost is a stable PGI2 analogue. The aims of the present study were (1) to evaluate the anti-aggregatory effect of Iloprost on feline platelet counts and to determine a useful concentration to inhibit platelet aggregation in EDTA samples from clinically healthy cats, (2) to investigate the effect of Iloprost on hematological blood parameters, and (3) to determine stability of Iloprost in K3-EDTA tubes for up to 16 weeks...
2015: BMC Veterinary Research
https://www.readbyqxmd.com/read/26243481/reply-to-letter-by-uslu-et-al-entitled-the-assessment-of-platelet-lymphocyte-ratio-based-on-edta-dependent-pseudothrombocytopenia
#20
LETTER
Uğur Canpolat, Mehmet Kadri Akboga
No abstract text is available yet for this article.
January 2016: Angiology
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