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https://www.readbyqxmd.com/read/29774564/mortality-in-sepsis-comparison-of-outcomes-between-patients-with-demand-ischemia-acute-myocardial-infarction-and-neither-demand-ischemia-nor-acute-myocardial-infarction
#1
Mahek Shah, Soumya Patnaik, Obiora Maludum, Brijesh Patel, Byomesh Tripathi, Manyoo Agarwal, Lohit Garg, Sahil Agrawal, Ulrich P Jorde, Matthew W Martinez
INTRODUCTION: Elevation in cardiac troponins is common among septic patients. We sought to explore outcomes among those admitted with demand ischemia(DI), acute myocardial infarction(AMI) and neither DI nor AMI in sepsis. METHODS: We analyzed data from the 2011-2014 National Inpatient Sample among patients admitted for sepsis. We compared outcomes among sepsis patients with i)DI versus AMI and ii)DI versus neither DI nor AMI using separate propensity matched cohorts...
May 18, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29759808/implementation-of-a-clinical-nursing-pathway-for-percutaneous-coronary-intervention-a-prospective-study
#2
Meng Li, Huimin Liu
This study is to evaluate the effect of a clinical nursing pathway (CNP) on the clinical outcomes of the transradial approach for emergency percutaneous coronary intervention (PCI). A total of 118 subjects diagnosed with acute myocardial infarction (AMI) were enrolled in the study. They were randomly divided into a control group receiving conventional nursing and a clinical nursing pathway group. The differences in door-to-balloon time, length of hospital stay, hospitalization cost, postoperative complications, and patient satisfaction with nursing care between the two groups were determined and analyzed statistically...
May 11, 2018: Geriatric Nursing
https://www.readbyqxmd.com/read/29734199/are-shorter-durations-of-dual-antiplatelet-therapy-acceptable-following-percutaneous-coronary-intervention
#3
Jessica M Lewis, James J Nawarskas
Much debate has centered on whether or not the standard 12 month duration of dual antiplatelet therapy (DAPT) is still necessary post-percutaneous coronary intervention (PCI) given recent improvements in stent technology. The benefits of shorter (3-6 months) durations of DAPT include a potential lower risk for bleeding and less patient drug cost and pill burden. While randomized clinical trials have shown non-inferiority for shorter versus longer DAPT regimens in many regards, some endpoints (e.g. myocardial infarction) may still occur less frequently with longer DAPT regimens, particularly in higher risk populations (e...
May 4, 2018: Cardiology in Review
https://www.readbyqxmd.com/read/29724635/mandatory-criteria-for-cardiac-rehabilitation-programs-2018-guidelines-from-the-portuguese-society-of-cardiology
#4
Ana Abreu, Miguel Mendes, Hélder Dores, Conceição Silveira, Paulo Fontes, Madalena Teixeira, Helena Santa Clara, João Morais
Cardiac rehabilitation (CR) is a multidisciplinary process for patients recovering after an acute cardiac event or with chronic cardiovascular disease that reduces mortality and morbidity and improves quality of life. It is considered a cost-effective intervention and is expressly indicated in the guidelines of the major medical societies. In Portugal, only 8% of patients discharged from hospital after myocardial infarction are included in CR programs. In Europe overall, the percentage admitted to CR programs is 30%, while in the USA it is 20-30%...
April 30, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29694293/development-of-a-pharmacoeconomic-model-to-demonstrate-the-effect-of-clinical-pharmacist-involvement-in-diabetes-management
#5
Heather Ourth, Jordan Nelson, Patrick Spoutz, Anthony P Morreale
BACKGROUND: A data collection tool was developed and nationally deployed to clinical pharmacists (CPs) working in advanced practice provider roles within the Department of Veterans Affairs to document interventions and associated clinical outcomes. Intervention and short-term clinical outcome data derived from the tool were used to populate a validated clinical outcomes modeling program to predict long-term clinical and economic effects. OBJECTIVE: To predict the long-term effect of CP-provided pharmacotherapy management on outcomes and costs for patients with type 2 diabetes...
May 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29693381/coreactant-free-and-label-free-eletrochemiluminescence-immunosensor-for-copeptin-based-on-luminescent-immuno-gold-nanoassemblys
#6
Zhili Han, Jiangnan Shu, Qiaoshi Jiang, Hua Cui
In this work, the eletrochemiluminescence (ECL) behavior of Cu2+ /cysteine complexes and N-(aminobutyl)-N-(ethylisoluminol) (ABEI) functionalized gold nanoparticles combined with chitosan (Cu2+ -Cys-ABEI-GNPs-CS) were studied by cyclic voltammetry and a double-step potential, which exhibited excellent ECL properties without any coreactant. It was found that the ECL intensity of Cu2+ -Cys-ABEI-GNPs-CS could increase at least one order of magnitude compared with that of Cu2+ -Cys-ABEI-GNPs. Furthermore, a coreactant-free and label-free ECL immunosensor has been established for the determination of early acute myocardial infarction biomarker copeptin based on luminescent immuno-gold nanoassemblys consisting of Cu2+ -Cys-ABEI-GNPs-CS and immuno-gold nanoparticles prepared by connecting copeptin antibody with trisodium citrate stabilized gold nanoparticles...
April 25, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29685587/the-pathophysiology-of-myocardial-infarction-induced-heart-failure
#7
REVIEW
Daniele Gabriel-Costa
Heart failure (HF) is a multifactorial disorder and is usually the end stage of many cardiovascular diseases (CVD). HF presents one of the highest morbidity and mortality indices worldwide and high costs to public health organizations. Myocardial infarction (MI) is the most prevalent CVD in the Western world and leads to HF when its management is inadequate. It has a destructive potential for heart cells and abruptly reduces the cardiac output, a clinical condition known as heart dysfunction that might progress to HF...
April 18, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29667144/efficacy-and-safety-of-zofenopril-versus-ramipril-in-the-treatment-of-myocardial-infarction-and-heart-failure-a-review-of-the-published-and-unpublished-data-of-the-randomized-double-blind-smile-4-study
#8
REVIEW
Claudio Borghi, Stefano Omboni, Salvatore Novo, Dragos Vinereanu, Giuseppe Ambrosio, Ettore Ambrosioni
Zofenopril is a lipophilic, sulfhydryl group-containing angiotensin-converting enzyme (ACE)-inhibitor, characterized by wide tissue distribution, long duration of action, and pleiotropic effects on endothelial dysfunction. Its clinical efficacy and safety have been described in the four randomized controlled trials of the SMILE program, which globally enrolled more than 3600 patients in post-acute myocardial infarction (AMI) setting. The SMILE-4 study specifically selected patients with left ventricular dysfunction at admission, and compared the effects of zofenopril or ramipril in combination with acetylsalicylic acid (ASA)...
April 17, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29666943/the-gtn-patch-a-simple-and-effective-new-approach-to-cardioprotection
#9
Derek M Yellon, Zhenhe He, Rayomand Khambata, Amrita Ahluwalia, Sean M Davidson
There remains a significant un-met need to reduce the extent of myocardial injury caused by ischaemia and reperfusion injury in patients experiencing an ST-elevation MI. Although nitric oxide is central to many cardioprotective strategies currently undergoing investigation, cardioprotection from the delivery of nitrates/nitrites has been inconsistently observed. The route of administration appears to be a critical variable. The glyceryl trinitrate (GTN) patch is commonly used as a simple and practical means of delivering nitric oxide to patients with ischaemic heart disease, but whether acute cardioprotection can be achieved by application of a GTN patch has not been investigated before...
April 17, 2018: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29655881/racial-differences-in-quality-of-care-and-outcomes-after-acute-coronary-syndrome
#10
Celina M Yong, Leo Ungar, Freddy Abnousi, Steven M Asch, Paul A Heidenreich
Guideline adherence and variation in acute coronary syndrome (ACS) outcomes by race in the modern era of drug-eluting stents (DES) are not well understood. Previous studies also fail to capture rapidly growing minority populations, such as Asians. A retrospective analysis of 689,238 hospitalizations for ACS across all insurance types from 2008 to 2011 from the Healthcare Cost and Utilization Project database was performed to determine whether quality of ACS care and mortality differ by race (white, black, Asian, Hispanic, or Native American), with adjustment for patient clinical and demographic characteristics and clustering by hospital...
March 13, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29651791/a-discrete-event-simulation-model-to-assess-the-economic-value-of-a-hypothetical-pharmacogenomics-test-for-statin-induced-myopathy-in-patients-initiating-a-statin-in-secondary-cardiovascular-prevention
#11
Dominic Mitchell, Jason R Guertin, Anick Dubois, Marie-Pierre Dubé, Jean-Claude Tardif, Ange Christelle Iliza, Fiorella Fanton-Aita, Alexis Matteau, Jacques LeLorier
BACKGROUND: Statin (HMG-CoA reductase inhibitor) therapy is the mainstay dyslipidemia treatment and reduces the risk of a cardiovascular (CV) event (CVE) by up to 35%. However, adherence to statin therapy is poor. One reason patients discontinue statin therapy is musculoskeletal pain and the associated risk of rhabdomyolysis. Research is ongoing to develop a pharmacogenomics (PGx) test for statin-induced myopathy as an alternative to the current diagnosis method, which relies on creatine kinase levels...
April 12, 2018: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/29625513/trends-characteristics-and-clinical-outcomes-of-patients-undergoing-percutaneous-coronary-intervention-in-korea-between-2011-and-2015
#12
Seungbong Han, Gyung Min Park, Yong Giun Kim, Mahn Won Park, Sung Ho Her, Seung Whan Lee, Young Hak Kim
BACKGROUND AND OBJECTIVES: We sought to evaluate nationwide trends, characteristics, and clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) in Korea. METHODS: From National Health Insurance claims data in Korea, 81,115 patients, who underwent PCI for the first episode of coronary artery disease between 2011 and 2015, were enrolled. Patients were categorized into angina (n=49,288) or acute myocardial infarction (AMI, n=31,887) groups and analyzed...
April 2018: Korean Circulation Journal
https://www.readbyqxmd.com/read/29623635/the-healthcare-cost-burden-of-acute-myocardial-infarction-in-alberta-canada
#13
Dat T Tran, Arto Ohinmaa, Nguyen X Thanh, Robert C Welsh, Padma Kaul
OBJECTIVES: Little is known about the cost burden of acute myocardial infarction (AMI) on healthcare systems. Accordingly, we examined the long-term trends of healthcare costs for AMI in the province of Alberta, Canada. METHODS: We linked five Albertan health databases, including ambulatory care, hospitalization, practitioner claims, pharmaceutical information network, and population registry to identify patients with a primary diagnosis of AMI between 2004 and 2013...
November 2, 2017: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29618581/causes-and-predictors-of-30-day-readmission-in-patients-with-acute-myocardial-infarction-and-cardiogenic-shock
#14
Mahek Shah, Shantanu Patil, Brijesh Patel, Manyoo Agarwal, Carlos D Davila, Lohit Garg, Sahil Agrawal, Navin K Kapur, Ulrich P Jorde
BACKGROUND: Acute myocardial infarction (AMI) occurs as a result of irreversible damage to cardiac myocytes secondary to lack of blood supply. Cardiogenic shock complicating AMI has significant associated morbidity and mortality, and data on postdischarge outcomes are limited. METHODS AND RESULTS: We derived the study cohort of patients with AMI and cardiogenic shock from the 2013 to 2014 Healthcare Cost and Utilization Project National Readmission Database. Incidence, predictors, and causes of 30-day readmissions were analyzed...
April 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29618148/previous-history-of-breast-cancer-increases-rates-of-pulmonary-embolism-and-costs-after-total-knee-arthroplasty-an-evaluation-of-185-114-matched-patients
#15
Samuel Rosas, T David Luo, Alexander H Jinnah, Alejandro Marquez-Lara, Martin W Roche, Cynthia L Emory
Risk factors for adverse events after total knee arthroplasty (TKA) relating to malignancy have not been well studied. Thus, the purpose of this study was to conduct a retrospective case-control outcome and cost analysis after TKA in this population. Patients with a history of breast cancer (BrCa) were identified based on the International Classification of Disease 9th revision codes. An age- and sex-matched cohort was also identified of patients without a history of BrCa. Complications, length of stay, comorbidity burden, and reimbursements were tracked at 90 days...
April 4, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29606641/is-transcatheter-aortic-valve-replacement-better-than-surgical-aortic-valve-replacement-in-patients-with-chronic-obstructive-pulmonary-disease-a-nationwide-inpatient-sample-analysis
#16
Tomo Ando, Oluwole Adegbala, Emmanuel Akintoye, Said Ashraf, Mohit Pahuja, Alexandros Briasoulis, Hisato Takagi, Cindy L Grines, Luis Afonso, Theodore Schreiber
BACKGROUND: Chronic obstructive pulmonary disease (COPD) patients are at increased risk of respiratory related complications after cardiac surgery. It is unclear whether transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR) results in favorable outcomes among COPD patients. METHODS AND RESULTS: Patients were identified from the Nationwide Inpatient Sample database from 2011 to 2014. Patients with age ≥60, COPD, and either went transarterial TAVR or SAVR were included in the analysis...
April 1, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29576493/aspiration-thrombectomy-versus-conventional-catheter-directed-thrombolysis-as-first-line-treatment-for-noniatrogenic-acute-lower-limb-ischemia
#17
C H Ricky Kwok, Scott Fleming, Kenneth K C Chan, Jonathan Tibballs, Shaun Samuelson, John Ferguson, Sanjay Nadkarni, Joseph A Hockley, Shirley J Jansen
PURPOSE: To examine the efficacy, safety, and procedural costs of percutaneous aspiration thrombectomy (PAT) as a first-line treatment for noniatrogenic acute lower limb ischemia (ALI) compared with conventional catheter-directed thrombolysis (CDT). MATERIALS AND METHODS: All patients who underwent endovascular intervention for ALI from January 2015 to August 2017 were included. Fifteen patients were treated with the use of primary PAT and 27 patients were treated with the use of primary CDT...
March 22, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29572325/prevalence-causes-and-predictors-of-30-day-readmissions-following-hospitalization-with-acute-myocardial-infarction-complicated-by-cardiogenic-shock-findings-from-the-2013-2014-national-readmissions-database
#18
Ahmed N Mahmoud, Islam Y Elgendy, Mohammad K Mojadidi, Siddharth A Wayangankar, Anthony A Bavry, R David Anderson, Hani Jneid, Carl J Pepine
BACKGROUND: Prior studies have shown that survivors of acute myocardial infarction (AMI) complicated by cardiogenic shock are likely to have increased risk of readmissions in the early post-discharge period. However, the contemporary prevalence, reasons, and predictors of 30-day readmissions are not well known. METHODS AND RESULTS: Hospitalizations for a primary diagnosis of AMI complicated by cardiogenic shock, and discharged alive, were identified in the 2013 and 2014 Nationwide Readmissions Databases...
March 23, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29557218/prospective-utility-study-of-patients-with-multiple-cardiovascular-events
#19
Rhys D Pockett, Phil McEwan, Joshua Ray, Irwin Tran, Simon Shutler, Steven Martin, Zaheer Yousef, Ameet Bakhai
OBJECTIVES: The effects of acute coronary syndrome (ACS) events on health-related quality-of-life (HRQoL) and the time dependency of these effects are unknown. This study aimed to characterize health utilities in ACS patients to aid development of future economic models estimating the cost per quality-adjusted life-year impact of ACS events and potential treatments. METHODS: Multi-center, non-interventional, longitudinal evaluation of health utility in patients experiencing ACS or stroke events...
April 3, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29547759/public-insurance-program-impact-on-catastrophic-health-expenditure-on-acute-myocardial-infarction
#20
M Martínez-García, J Vargas-Barrón, F Bañuelos-Téllez, H González-Pacheco, C Fresno, E Hernández-Lemus, M A Martínez-Ríos, M Vallejo
OBJECTIVE: ST-segment elevation myocardial infarction (STEMI) has an important economic burden that poised the urgent need to evaluate its catastrophic medical expense. This study evaluates the first 5 years of the national health initiative called Popular Insurance (PI) at the National Institute of Cardiology in Mexico. STUDY DESIGN: Retrospective data analysis. METHODS: STEMI patients with (n=317) and without (n=260) PI were selected. Analysed variables included socio-economical context, management care, cost evaluation and three outcomes (mortality, hospital readmission and therapeutic adherence)...
March 13, 2018: Public Health
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