keyword
https://read.qxmd.com/read/38527707/circular-rna-circefnb2-promotes-cell-injury-after-cerebral-infarction-by-sponging-mir-202-5p-and-regulating-traf3-expression
#21
JOURNAL ARTICLE
Limin Tu, Wei Cheng, Xudong Wang, Zhixin Li, Xing Li
BACKGROUND: Exogenous neural cell transplantation may be therapeutic for stroke, cerebral ischemic injury. Among other mechanisms, increasing findings indicated circular RNAs (circRNAs) regulate the pathogenesis progression of cerebral ischemia. Mmu_circ_0015034 (circEfnb2) was upregulated in focal cortical infarction established by middle cerebral artery occlusion (MCAO) in mice. Our study was designed to probe the molecular mechanism of circEfnb2 in the oxygen-glucose deprivation/reperfusion (OGD/R)-induced neuronal damage in cerebral ischemia...
March 23, 2024: Transplant Immunology
https://read.qxmd.com/read/38524397/circular-rna-expression-of-peripheral-blood-mononuclear-cells-associated-with-risk-of-acute-exacerbation-in-smoking-chronic-obstructive-pulmonary-disease
#22
JOURNAL ARTICLE
Xu-Rui Shen, Ying-Ying Liu, Rui-Qi Qian, Wei-Yun Zhang, Jian-An Huang, Xiu-Qin Zhang, Da-Xiong Zeng
PURPOSE: Circular RNAs (circRNAs) are newly identified endogenous non-coding RNAs that function as crucial gene modulators in the development of several diseases. By assessing the expression levels of circRNAs in peripheral blood mononuclear cells (PBMCs) from patients with chronic obstructive pulmonary disease (COPD), this study attempted to find new biomarkers for COPD screening. PATIENTS AND METHODS: We confirmed altered circRNA expression in PBMCs of COPD (n=41) vs controls (n=29)...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38524131/long-noncoding-rnas-and-circular-rnas-as-potential-diagnostic-biomarkers-of-inflammatory-bowel-diseases-a-systematic-review-and-meta-analysis
#23
Melaku Ashagrie Belete, Selamyhun Tadesse, Mihret Tilahun, Alemu Gedefie, Agumas Shibabaw, Zewudu Mulatie, Muluken Amare Wudu, Saba Gebremichael, Habtu Debash, Mihreteab Alebachew, Ermiyas Alemayehu
INTRODUCTION: Inflammatory bowel disease (IBD) poses a growing global burden, necessitating the discovery of reliable biomarkers for early diagnosis. The clinical significance of dysregulated expression of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in diagnosing IBD has not been well established. Thus, our study aimed to investigate the diagnostic value of lncRNAs and circRNAs for IBD based on currently available studies. METHODS: A comprehensive search was carried out in diverse electronic databases, such as PubMed, Embase, Scopus, Science Direct and Wiley Online Library to retrieve articles published until October 30, 2023...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38523597/circitga7-regulates-malignant-phenotypes-in-bladder-cancer-cells-via-targeting-mir-330-3p-klf10-axis
#24
JOURNAL ARTICLE
Xian-Xu Yang, Chao Wang
Bladder cancer (BCa) is one of the common malignancies. Circular RNAs (circRNAs) play regulatory roles in cancer progression. CircITGA7 is a circRNA generated from several exons of ITGA7. The potential role of circITGA7 in BCa remains unknown and needs to be explored. Quantitative real time polymerase chain reaction (qRT-PCR) was used to assess circITGA7 and miR-330-3p expression in BCa tissues and cell lines. Kaplan-Meier analysis was used to evaluate the overall survival of these BCa patients. The biological function of circITGA7 was examined by overexpression of circITGA7 using CCK-8, EdU, wound-healing, and Transwell assays...
March 25, 2024: Kaohsiung Journal of Medical Sciences
https://read.qxmd.com/read/38521909/circ_0070934-promotes-mgat3-expression-and-inhibits-epithelial-mesenchymal-transition-in-bronchial-epithelial-cells-by-sponging-mir-199a-5p
#25
JOURNAL ARTICLE
Ziqi Ding, Xinru Xiao, Liang Fan, Zhengdao Mao, Chuang Sun, Na Li, Qian Zhang
BACKGROUND: Circular RNA (circRNA) has the potential to serve as a crucial regulator in the progression of bronchial asthma. The objective of this investigation was to elucidate the functional dynamics of the circ_0070934/miR-199a-5p/Mannoside acetylglucosaminyltransferase 3 (MGAT3) axis in the development of asthma. METHODS: Circ_0070934, miR-199a-5p and MGAT3 in peripheral venous blood of 38 asthmatic patients and 43 healthy controls were detected by qRT-PCR, and the expression of MGAT3 protein was examined by ELISA...
March 23, 2024: Allergy, Asthma, and Clinical Immunology
https://read.qxmd.com/read/38520611/parkinson-s-disease-and-micrornas-a-duel-between-inhibition-and-stimulation-of-apoptosis-in-neuronal-cells
#26
REVIEW
Mohamed J Saadh, Ahmed Faisal, Mohaned Adil, Rahman S Zabibah, Abdurakhmon Mamatkulovich Mamadaliev, Mahmood Jasem Jawad, Fahad Alsaikhan, Bagher Farhood
Parkinson's disease (PD) is one of the most prevalent diseases of central nervous system that is caused by degeneration of the substantia nigra's dopamine-producing neurons through apoptosis. Apoptosis is regulated by initiators' and executioners' caspases both in intrinsic and extrinsic pathways, further resulting in neuronal damage. In that context, targeting apoptosis appears as a promising therapeutic approach for treating neurodegenerative diseases. Non-coding RNAs-more especially, microRNAs, or miRNAs-are a promising target for the therapy of neurodegenerative diseases because they are essential for a number of cellular processes, including signaling, apoptosis, cell proliferation, and gene regulation...
March 23, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38520572/role-of-circular-rna-mirna-axes-in-the-pathophysiology-of-polycystic-ovary-syndrome
#27
REVIEW
Mohsen Ahmadi, Mohadeseh Fathi, Ali Malmir, Soudeh Ghafouri-Fard
Polycystic ovary syndrome (PCOS) is a disorder resulted from interactions between genetic and environmental factors. Based on the importance of epigenetic factors in the pathoetiology of PCOS, the current review focused on identification of circular RNAs (circRNAs) that are involved in PCOS through acting as molecular sponges for microRNAs (miRNAs). The literature search led to identification of circ_0043533/miR-1179, circ_0030018/miR-136, circ_FURIN/miR-423-5p, circ-FURIN/miR-195-5p, circ_0043532/miR-182, circ_RANBP9/miR-136-5p, circRHBG/miR-515-5p, circMTO1/miR-320b, circASPH/miR-375, circPSMC3/miR-296-3p, circLDLR/miR-1294, circPUM1/miR-760, and hsa_circ_0118530/miR-136 as molecular axes contributing to the pathogenesis of PCOS...
March 23, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38520208/exosomal-circstrbp-from-cancer-cells-facilitates-gastric-cancer-progression-via-regulating-mir-1294-mir-593-3p-e2f2-axis
#28
JOURNAL ARTICLE
Yin Wang, Rong Zou, Deke Li, Xiankui Gao, Xingjun Lu
CircRNAs represent a new class of non-coding RNAs which show aberrant expression in diverse cancers, such as gastric cancer (GC). circSTRBP, for instance, is suggested to be overexpressed in GC cells and tissues. However, the biological role of circSTRBP in the progression of GC and the potential mechanisms have not been investigated. circSTRBP levels within GC cells and tissues were measured by RT-qPCR. The stability of circSTRBP was assessed by actinomycin D and Ribonuclease R treatment. Cell proliferation, migration, invasion and in vitro angiogenic abilities after circSTRBP knockdown were analysed through CCK-8 assay, transwell culture system and the tube formation assay...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38517991/differential-expression-of-circular-rnas-in-human-umbilical-cord-mesenchymal-stem-cells-treated-with-icariin
#29
JOURNAL ARTICLE
Xiaokun Liu, Xiaoqian Chu, Lingling Li, Shanshan Man, Li Wang, Yuhong Bian, Huifang Zhou
Human umbilical cord mesenchymal stem cells (hUMSCs) belong to a multipotent stem cell population. Transplantation of icariin (ICA)-treated hUMSCs have better tissue repairing function in chronic liver injury. This study was to investigate whether the tissue-repairing effects and migration of hUMSCs after ICA treatment were regulated by circular RNAs (circRNAs). ICA was used to treat hUMSCs in vitro for 1 week and the expression profiles of circRNAs were generated using RNA sequencing. Differentially expressed circRNAs in hUMSCs after ICA intervention were screened...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38517354/hijacking-and-rewiring-of-host-circrna-mirna-mrna-competitive-endogenous-rna-cerna-regulatory-networks-by-oncoviruses-during-development-of-viral-cancers
#30
REVIEW
Mohammad Javad Kamali, Mohammad Salehi, Mehrnaz Mostafavi, Reza Morovatshoar, Mitra Akbari, Narges Latifi, Omid Barzegari, Fatemeh Ghadimi, Abdolreza Daraei
A significant portion of human cancers are caused by oncoviruses (12%-25%). Oncoviruses employ various strategies to promote their replication and induce tumourigenesis in host cells, one of which involves modifying the gene expression patterns of the host cells, leading to the rewiring of genes and resulting in significant changes in cellular processes and signalling pathways. In recent studies, a specific mode of gene regulation known as circular RNA (circRNA)-mediated competing endogenous RNA (ceRNA) networks has emerged as a key player in this context...
March 2024: Reviews in Medical Virology
https://read.qxmd.com/read/38516776/circular-rnas-and-the-regulation-of-gene-expression-in-diabetic-nephropathy-review
#31
JOURNAL ARTICLE
Maximo Berto Martinez Benitez, Yussel Pérez Navarro, Elisa Azuara-Liceaga, Angeles Tecalco Cruz, Jesús Valdés Flores, Lilia Lopez-Canovas
Circular RNAs (circRNAs) are non‑coding single‑stranded covalently closed RNA molecules that are considered important as regulators of gene expression at the transcriptional and post‑transcriptional levels. These molecules have been implicated in the initiation and progression of multiple human diseases, ranging from cancer to inflammatory and metabolic diseases, including diabetes mellitus and its vascular complications. The present article aimed to review the current knowledge on the biogenesis and functions of circRNAs, as well as their role in cell processes associated with diabetic nephropathy...
May 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38515791/non-coding-rna-transcripts-incredible-modulators-of-cisplatin-chemo-resistance-in-bladder-cancer-through-operating-a-broad-spectrum-of-cellular-processes-and-signaling-mechanism
#32
REVIEW
Mehrdad Hashem, Elaheh Mohandesi Khosroshahi, Melika Aliahmady, Morvarid Ghanei, Yasamin Soofi Rezaie, Yasamin Alsadat Jafari, Fatemeh Rezaei, Ramtin Khodaparast Eskadehi, Kimia Kia Kojoori, Faranak Jamshidian, Noushin Nabavi, Mohsen Rashidi, Farzaneh Hasani Sadi, Afshin Taheriazam, Maliheh Entezari
Bladder cancer (BC) is a highly frequent neoplasm in correlation with significant rate of morbidity, mortality, and cost. The onset of BC is predominantly triggered by environmental and/or occupational exposures to carcinogens, such as tobacco. There are two distinct pathways by which BC can be developed, including non-muscle-invasive papillary tumors (NMIBC) and non-papillary (or solid) muscle-invasive tumors (MIBC). The Cancer Genome Atlas project has further recognized key genetic drivers of MIBC along with its subtypes with particular properties and therapeutic responses; nonetheless, NMIBC is the predominant BC presentation among the suffering individuals...
June 2024: Non-Coding RNA Research
https://read.qxmd.com/read/38515760/crosstalk-between-ubiquitin-ligases-and-ncrnas-drives-cardiovascular-disease-progression
#33
REVIEW
Jia-Rui You, Zeng-Jin Wen, Jia-Wei Tian, Xiao-Bing Lv, Rong Li, Shu-Ping Li, Hui Xin, Pei-Feng Li, Yin-Feng Zhang, Rui Zhang
Cardiovascular diseases (CVDs) are multifactorial chronic diseases and have the highest rates of morbidity and mortality worldwide. The ubiquitin-proteasome system (UPS) plays a crucial role in posttranslational modification and quality control of proteins, maintaining intracellular homeostasis via degradation of misfolded, short-lived, or nonfunctional regulatory proteins. Noncoding RNAs (ncRNAs, such as microRNAs, long noncoding RNAs, circular RNAs and small interfering RNAs) serve as epigenetic factors and directly or indirectly participate in various physiological and pathological processes...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38515149/circhas2-activates-ccne2-to-promote-cell-proliferation-and-sensitizes-the-response-of-colorectal-cancer-to-anlotinib
#34
JOURNAL ARTICLE
Haosheng Li, Haoran Feng, Tao Zhang, Junwei Wu, Xiaonan Shen, Shuiyu Xu, Lianghui Xu, Shaodong Wang, Yaqi Zhang, Wenqing Jia, Xiaopin Ji, Xi Cheng, Ren Zhao
BACKGROUND: Tyrosine kinase inhibitors (TKIs) are crucial in the targeted treatment of advanced colorectal cancer (CRC). Anlotinib, a multi-target TKI, has previously been demonstrated to offer therapeutic benefits in previous studies. Circular RNAs (circRNAs) have been implicated in CRC progression and their unique structural stability serves as promising biomarkers. The detailed molecular mechanisms and specific biomarkers related to circRNAs in the era of targeted therapies, however, remain obscure...
March 21, 2024: Molecular Cancer
https://read.qxmd.com/read/38514579/circular-rna-circchsy1-silencing-inhibits-the-malignant-progression-of-esophageal-squamous-cell-carcinoma
#35
JOURNAL ARTICLE
Haiquan He, Ying Chen, Hanping Liang, Weibi Che, Huilong Chen, Ying Chen, Fengyuan Peng, Bomeng Wu
BACKGROUND: CircRNAs play a crucial role in the regulation of various cancers. This study aims to investigate the involvement of circCHSY1 in the development of esophageal squamous cell carcinoma (ESCC). METHODS: RNA levels were quantified using qRT-PCR, and protein levels were measured by western blot. The stability of circCHSY1 was analyzed using RNase R. The functional effect of circCHSY1 on cell behavior was evaluated by CCK-8, EdU, flow cytometry, transwell, tube formation, and xenograft tumor model assays...
March 21, 2024: Discover. Oncology
https://read.qxmd.com/read/38513802/epigenetic-regulation-of-hepatocellular-carcinoma-progression-micrornas-as-therapeutic-diagnostic-and-prognostic-factors
#36
JOURNAL ARTICLE
Mehrdad Hashemi, Pouria Daneii, Mahya Asadalizadeh, Kiana Tabari, Arash Matinahmadi, Seyed Shahabadin Bidoki, Yasamin Sadat Mousavi Motlagh, Ali Moghadas Jafari, Amin Ghorbani, Amir Dehghanpour, Noushin Nabavi, Shing Cheng Tan, Mohsen Rashidi, Afshin Taheriazam, Maliheh Entezari, Mohammad Ali Sheikhbeig Goharrizi
Hepatocellular carcinoma (HCC), a significant challenge for public healthcare systems in developed Western countries including the USA, Canada, and the UK, is influenced by different risk factors including hepatitis virus infections, alcoholism, and smoking. The disruption in the balance of microRNAs (miRNAs) plays a vital function in tumorigenesis, given their function as regulators in numerous signaling networks. These miRNAs, which are mature and active in the cytoplasm, work by reducing the expression of target genes through their impact on mRNAs...
March 19, 2024: International Journal of Biochemistry & Cell Biology
https://read.qxmd.com/read/38513741/targeting-non-coding-rnas-and-n-6-methyladenosine-modification-in-hepatocellular-carcinoma
#37
REVIEW
Lin Wu, Yingmei Zhang, Jun Ren
Hepatocellular carcinoma (HCC), the most common form of primary liver cancers, accounts for a significant portion of cancer-related death globally. However, the molecular mechanisms driving the onset and progression of HCC are still not fully understood. Emerging evidence has indicated that non-protein-coding regions of genomes could give rise to transcripts, termed non-coding RNA (ncRNA), forming novel functional driving force for aberrant cellular activity. Over the past decades, overwhelming evidence has denoted involvement of a complex array of molecular function of ncRNAs at different stages of HCC tumorigenesis and progression...
March 19, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38513259/identification-and-characterization-of-circular-rnas-expression-profiles-in-obstructive-sleep-apnea-induced-liver-injury
#38
JOURNAL ARTICLE
Chaowei Li, Jinhuang Lin, Qingshi Chen, Yueyong Zhu
Circular RNAs (circRNAs) have exhibited microRNA sponge activity, related to many important biological processes. Our study attempted to explore the comprehensive changes of circRNAs expression pattern in Obstructive sleep apnea (OSA)-induced liver injury and provide a global perspective of differentially expressed circRNAs (DECs). Then, RT-qPCR was used to confirm the microarray data. Further, gene ontology (GO) and KEGG pathway analysis were performed to annotate the DECs. Finally, the circRNA-miRNA-mRNA interaction network was established to predicted the target genes and target miRNAs of DECs for a stepwise bioinformatics analysis...
March 21, 2024: Aging
https://read.qxmd.com/read/38513057/circ-eif3i-promotes-hepatocellular-carcinoma-progression-through-modulating-mir-361-3p-dusp2-axis
#39
JOURNAL ARTICLE
Lingna Ni, Qianqian Gao, Qiu Zhao, Kejun Dai, Mingming Jin, Cong Fu, Min Xiao, Wenyu Zhu, Yanzhi Bi
Hepatocellular carcinoma (HCC) is one of the most common malignant cancers globally. Circular RNAs (circRNAs) have been implicated in the development of HCC. Previous studies have confirmed that circ-EIF3I plays an important role in the progress of lung cancer. Nevertheless, the biological functions of circ-EIF3I and the underlying mechanisms by which they regulate HCC progression remain unclear. In this study, the regulatory mechanism and targets were studied with bioinformatics analysis, luciferase reporting analysis, transwell migration, Cell Counting Kit-8, and 5-Ethynyl-2'-deoxyuridine analysis...
March 22, 2024: DNA and Cell Biology
https://read.qxmd.com/read/38511064/circzcchc2-hsa_circ_0000854-promotes-hepatocellular-carcinoma-progression-through-modulating-mir-936-btbd7-axis-and-activating-rho-rock2-pathway
#40
JOURNAL ARTICLE
Junjie Yin, Mian Wang, Jian Chen, Huigang Li, Jianyong Zhuo, Bei Lu, Yang Cai
Hepatocellular carcinoma (HCC) is one of the most aggressive and refractory cancers due to its high propensity to metastasize and the unavailability of efficacious treatments. Circular RNAs (circRNAs) participate in diverse biological activities in human cancers. Here, we detected the upregulation of a novel circRNA, circZCCHC2 (hsa_circ_0000854), in HCC samples and cells. The upregulation indicated an unfavorable prognosis in HCC patients. CircZCCHC2 accelerated cell growth and metastasis in vitro and tumorigenicity in vivo ...
June 2024: Non-Coding RNA Research
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