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https://www.readbyqxmd.com/read/28632645/management-of-symptomatic-lumbar-disk-herniation-an-international-perspective
#1
Pravesh S Gadjradj, Mark P Arts, Maurits W van Tulder, Wim J R Rietdijk, Wilco C Peul, Biswadjiet S Harhangi
STUDY DESIGN: A questionnaire survey. OBJECTIVE: To evaluate the current practice patterns of surgeons regarding both the surgical and nonsurgical management of lumbar disk herniation (LDH) worldwide and to compare this with the current literature. SUMMARY OF BACKGROUND DATA: Sciatica is a common diagnosis in the general population. Sciatica is most frequently caused by LDH. Multiple surgical techniques and treatment modalities are available to treat LDH, albeit some with small effect sizes or without compelling evidence...
June 19, 2017: Spine
https://www.readbyqxmd.com/read/28629126/differentiated-thyroid-cancer-treatment-state-of-the-art
#2
REVIEW
Benedikt Schmidbauer, Karin Menhart, Dirk Hellwig, Jirka Grosse
Differentiated thyroid cancer (DTC) is a rare malignant disease, although its incidence has increased over the last few decades. It derives from follicular thyroid cells. Generally speaking, the prognosis is excellent. If treatment according to the current guidelines is given, cases of recurrence or persistence are rare. DTC requires special expertise by the treating physician. In recent years, new therapeutic options for these patients have become available. For this article we performed a systematic literature review with special focus on the guidelines of the American Thyroid Association, the European Association of Nuclear Medicine, and the German Society of Nuclear Medicine...
June 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28622361/prevalence-trend-and-risk-factors-for-antiretroviral-therapy-discontinuation-among-hiv-infected-adults-in-ethiopia-in-2003-2015
#3
Hailay Abrha Gesesew, Paul Ward, Kifle Woldemichael, Lillian Mwanri
BACKGROUND: It is well acknowledged that antiretroviral therapy (ART) discontinuation hampers the progress towards achieving the UNAIDS treatment targets that aim to treat 90% of HIV diagnosed patients and achieve viral suppression for 90% of those on treatment. Nevertheless, the magnitude, trend and risk factors for ART discontinuation have not been explored extensively. We carried out a retrospective data analysis to assess prevalence, trend and risk factors for ART discontinuation among adults in Southwest Ethiopia...
2017: PloS One
https://www.readbyqxmd.com/read/28616986/on-a-chip-biosensing-based-on-all-dielectric-nanoresonators
#4
Ozlem Yavas, Mikael Svedendahl, Paulina Dobosz, Vanesa Sanz, Romain Quidant
Nanophotonics has become a key enabling technology in biomedicine with great promises in early diagnosis and less invasive therapies. In this context, the unique capability of plasmonic noble metal nanoparticles to concentrate light on the nanometer scale has widely contributed to biosensing and enhanced spectroscopy. Recently, high-refractive index dielectric nanostructures featuring low loss resonances have been proposed as a promising alternative to nanoplasmonics, potentially offering better sensing performances along with full compatibility with the microelectronics industry...
June 16, 2017: Nano Letters
https://www.readbyqxmd.com/read/28606065/neurocognitive-function-in-hiv-infected-persons-with-asymptomatic-cryptococcal-antigenemia-a-comparison-of-three-prospective-cohorts
#5
Martha P Montgomery, Noeline Nakasujja, Bozena M Morawski, Radha Rajasingham, Joshua Rhein, Elizabeth Nalintya, Darlisha A Williams, Kathy Huppler Hullsiek, Agnes Kiragga, Melissa A Rolfes, Renee Donahue Carlson, Nathan C Bahr, Kate E Birkenkamp, Yukari C Manabe, Paul R Bohjanen, Jonathan E Kaplan, Andrew Kambugu, David B Meya, David R Boulware
BACKGROUND: HIV-infected persons with detectable cryptococcal antigen (CrAg) in blood have increased morbidity and mortality compared with HIV-infected persons who are CrAg-negative. This study examined neurocognitive function among persons with asymptomatic cryptococcal antigenemia. METHODS: Participants from three prospective HIV cohorts underwent neurocognitive testing at the time of antiretroviral therapy (ART) initiation. Cohorts included persons with cryptococcal meningitis (N = 90), asymptomatic CrAg + (N = 87), and HIV-infected persons without central nervous system infection (N = 125)...
June 12, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28605418/should-we-be-testing-for-baseline-integrase-resistance-in-patients-newly-diagnosed-with-hiv
#6
Yiannis Koullias, Paul E Sax, Naomi F Fields, Rochelle P Walensky, Emily P Hyle
Background: Current guidelines recommend genotype resistance testing at diagnosis to guide initial selection of antiretroviral therapy (ART). Many standard resistance genotypes exclude testing for resistance to integrase inhibitors ("IR-testing"), although this class of drugs is a component of most recommended first-line regimens. Methods: We compared the 96-week clinical outcomes and cost-effectiveness of two strategies: no IR-testing vs. IR-testing performed at HIV diagnosis...
June 9, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28605172/pharmacy-refill-data-can-be-used-to-predict-virologic-failure-for-patients-on-antiretroviral-therapy-in-brazil
#7
David Martin, Paula M Luz, Jordan E Lake, Jesse L Clark, Dayse P Campos, Valdilea G Veloso, Ronaldo I Moreira, Sandra W Cardoso, Jeffrey D Klausner, Beatriz Grinsztejn
INTRODUCTION: Pharmacy adherence measures such as pharmacy dispensing ratios (PDRs) have previously been shown to be predictive of virologic outcomes. We aimed to determine the optimal interval of PDR assessment for predicting virologic failure for HIV-infected patients on antiretroviral therapy (ART). METHODS: Using national Brazilian ART pharmacy refill data, we examined PDRs for patients ≥18 years of age with at least one HIV RNA level ≥180 days after ART initiation on or after 1 January 2011...
June 5, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28603710/use-of-non-prescription-remedies-by-ghanaian-human-immunodeficiency-virus-positive-persons-on-antiretroviral-therapy
#8
Amos K Laar, Awewura Kwara, Priscillia A Nortey, Augustine K Ankomah, Michael P K Okyerefo, Margaret Y Lartey
BACKGROUND: Inappropriate use of non-prescription remedies by persons living with human immunodeficiency virus (PLHIV) may result in adverse events or potentiate non-adherence to prescribed medications. This study investigated the use of non-prescription remedies among PLHIV receiving antiretroviral therapy (ART) from four treatment centers in southern Ghana. METHODS: A mixed method design using quantitative and qualitative methods was used. This article focuses on the quantitative survey of 540 respondents...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28602895/risk-factors-for-sub-optimal-utilization-of-statins-and-antiplatelet-therapy-in-patients-undergoing-revascularization-for-symptomatic-peripheral-arterial-disease
#9
Andrew J Meltzer, Art Sedrakyan, Peter H Connolly, Sharif Ellozy, Darren B Schneider
OBJECTIVE: The objective of this study is to identify risk factors for sub-optimal medical therapy (defined as reported antiplatelet and statin use) among patients undergoing lower extremity bypass (LEB) and percutaneous interventions (PVI) for symptomatic peripheral arterial disease (PAD). METHODS: The Vascular Study Group of Greater New York (VSGGNY) database was used to identify all patients undergoing PVI or LEB for PAD (2011-2013). Bivariate analyses were performed to identifycharacteristics of patients who were not prescribed statins and/or antiplatelet agents prior to revascularization...
June 7, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28600129/angiogenic-peptide-nanofibers-repair-cardiac-tissue-defect-after-myocardial-infarction
#10
Abdul Jalil Rufaihah, I Ceren Yasa, Vaibavi Srirangam Ramanujam, Suganya Cheyyatraivendran Arularasu, Theo Kofidis, Mustafa O Guler, Ayse B Tekinay
Myocardial infarction remains one of the top leading causes of death in the world and the damage sustained in the heart eventually develops into heart failure. Limited conventional treatment options due to the inability of the myocardium to regenerate after injury and shortage of organ donors require the development of alternative therapies to repair the damaged myocardium. Current efforts in repairing damage after myocardial infarction concentrates on using biologically derived molecules such as growth factors or stem cells, which carry risks of serious side effects including the formation of teratomas...
June 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28595774/feasibility-of-using-single-photon-counting-x-ray-for-lung-tumor-position-estimation-based-on-4d-ct
#11
Katharina P Aschenbrenner, Christian V Guthier, Yulia Lyatskaya, Judit Boda-Heggemann, Frederik Wenz, Jürgen W Hesser
PURPOSE: In stereotactic body radiation therapy of lung tumors, reliable position estimation of the tumor is necessary in order to minimize normal tissue complication rate. While kV X-ray imaging is frequently used, continuous application during radiotherapy sessions is often not possible due to concerns about the additional dose. Thus, ultra low-dose (ULD) kV X-ray imaging based on a single photon counting detector is suggested. This paper addresses the lower limit of photons to locate the tumor reliably with an accuracy in the range of state-of-the-art methods, i...
June 5, 2017: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/28591025/neurocognitive-development-in-hiv-positive-children-is-correlated-with-plasma-viral-loads-in-early-childhood
#12
Valentin Weber, Daniel Radeloff, Bianca Reimers, Emilia Salzmann-Manrique, Peter Bader, Dirk Schwabe, Christoph Königs
Because of neurocognitive impairments in perinatally human immunodeficiency virus (HIV)-infected children and adolescents, this study aimed to demonstrate the effect of plasma viral loads and early initiation of sufficient combined antiretroviral therapy (cART) on neurocognitive development.In total, 14 perinatally infected HIV-positive children (median age 8.24 years [range: 6.0-16.74]) receiving lopinavir/ritonavir (LPV/r)-based ART underwent neurocognitive testing using the Wechsler Intelligence Score for Children, 4th Edition (WISC-IV)...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28590330/hiv-birth-testing-and-linkage-to-care-for-hiv-infected-infants-workshop-synopsis
#13
Patrick Jean-Philippe, Hans Spiegel, Devasena Gnanashanmugam, Joseph Fitzgibbon, Patricia DʼSouza, Keith W Crawford, Lakshmi Jayashankar, Melanie C Bacon, Shaffiq M Essajee, Grace M Aldrovandi, Mark Cotton, Elaine J Abrams
On May 5-6, 2016, the Division of AIDS of the National Institute of Allergy and Infectious Diseases convened a workshop on "HIV Birth Testing and Linkage to Care for HIV Infected Infants". The goal of the workshop was to evaluate birth testing for early infant diagnosis (EID) of HIV, delineate technological resources for advancing a point of care (POC) HIV test implementable at birth and chart out the implementation hurdles for initiating early antiretroviral therapy (ART) to HIV-infected infants diagnosed at birth...
June 5, 2017: AIDS
https://www.readbyqxmd.com/read/28588979/determinants-of-adherence-to-antiretroviral-therapy-among-hiv-positive-adults-in-sub-saharan-africa-a-systematic-review
#14
Tessa Heestermans, Joyce L Browne, Susan C Aitken, Sigrid C Vervoort, Kerstin Klipstein-Grobusch
OBJECTIVE: The rapid scale up of antiretroviral treatment (ART) in sub-Saharan Africa (SSA) has resulted in an increased focus on patient adherence. Non-adherence can lead to drug-resistant HIV caused by failure to achieve maximal viral suppression. Optimal treatment requires the identification of patients at high risk of suboptimal adherence and targeted interventions. The aim of this review was to identify and summarise determinants of adherence to ART among HIV-positive adults. DESIGN: Systematic review of adherence to ART in SSA from January 2002 to October 2014...
November 2016: BMJ Global Health
https://www.readbyqxmd.com/read/28588467/literature-review-on-the-effects-of-tdcs-coupled-with-robotic-therapy-in-post-stroke-upper-limb-rehabilitation
#15
REVIEW
Davide Simonetti, Loredana Zollo, Stefano Milighetti, Sandra Miccinilli, Marco Bravi, Federico Ranieri, Giovanni Magrone, Eugenio Guglielmelli, Vincenzo Di Lazzaro, Silvia Sterzi
Today neurological diseases such as stroke represent one of the leading cause of long-term disability. Many research efforts have been focused on designing new and effective rehabilitation strategies. In particular, robotic treatment for upper limb stroke rehabilitation has received significant attention due to its ability to provide high-intensity and repetitive movement therapy with less effort than traditional methods. In addition, the development of non-invasive brain stimulation techniques such as transcranial Direct Current Stimulation (tDCS) has also demonstrated the capability of modulating brain excitability thus increasing motor performance...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28584857/evolving-failures-in-the-delivery-of-human-immunodeficiency-virus-care-lessons-from-a-ugandan-meningitis-cohort-2006-2016
#16
Andrew G Flynn, David B Meya, Katherine Huppler Hullsiek, Joshua Rhein, Darlisha A Williams, Abdu Musubire, Bozena M Morawski, Kabanda Taseera, Alisat Sadiq, Liberica Ndyatunga, Mollie Roediger, Radha Rajasingham, Paul R Bohjanen, Conrad Muzoora, David R Boulware
BACKGROUND: Because of investments in human immunodeficiency virus (HIV) care in sub-Saharan Africa, the number of people aware of their status and receiving antiretroviral therapy (ART) has increased; however, HIV/acquired immune deficiency syndrome (AIDS) mortality still remains high. METHODS: We performed retrospective analysis of 3 sequential prospective cohorts of HIV-infected Ugandan adults presenting with AIDS and meningitis from 2006 to 2009, 2010 to 2012, and 2013 to 2016...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28584853/the-presence-of-human-immunodeficiency-virus-associated-neurocognitive-disorders-is-associated-with-a-lower-adherence-to-combined-antiretroviral-treatment
#17
Susan Kamal, Isabella Locatelli, Gilles Wandeler, Asemaneh Sehhat, Olivier Bugnon, Melanie Metral, Renaud Du Pasquier, Klemens Gutbrod, Matthias Cavassini, Marie P Schneider
BACKGROUND: Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) are defined according to their diagnostic degrees as follows: asymptomatic neurocognitive impairment, mild neurocognitive disorder, and HIV-associated dementia. Because high adherence to combined antiretroviral therapy (cART) is required to maintain viral suppression among HIV-infected patients, it is important to investigate the impact of HAND on medication adherence. Our study hypothesis was that patients with HAND had a lower medication adherence than patients who did not have HAND...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28582463/drug-resistance-testing-through-remote-genotyping-and-predicted-treatment-options-in-human-immunodeficiency-virus-type-1-infected-tanzanian-subjects-failing-first-or-second-line-antiretroviral-therapy
#18
Jenny Svärd, Sabina Mugusi, Doreen Mloka, Ujjwal Neogi, Genny Meini, Ferdinand Mugusi, Francesca Incardona, Maurizio Zazzi, Anders Sönnerborg
INTRODUCTION: Antiretroviral therapy (ART) has been successfully introduced in low-middle income countries. However an increasing rate of ART failure with resistant virus is reported. We therefore described the pattern of drug resistance mutations at antiretroviral treatment (ART) failure in a real-life Tanzanian setting using the remote genotyping procedure and thereafter predicted future treatment options using rule-based algorithm and the EuResist bioinformatics predictive engine. According to national guidelines, the default first-line regimen is tenofovir + lamivudine + efavirenz, but variations including nevirapine, stavudine or emtricitabine can be considered...
2017: PloS One
https://www.readbyqxmd.com/read/28580712/kawasaki-disease-state-of-the-art
#19
Jane W Newburger
Kawasaki disease is an acute febrile arteritis of childhood that can result in coronary artery aneurysms if untreated in the first 10 and ideally 7 days of illness. Kawasaki disease begins as a necrotizing arteritis with neutrophilic infiltrate, followed by subacute/chronic changes and luminal myofibroblastic proliferation that can cause coronary artery stenosis. Manifestations include the presence of ≥5 days of fever, together with clinical criteria of extremity changes, rash, conjunctivitis, oral changes, and unilateral cervical lymphadenopathy...
June 5, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28578226/cocaine-use-may-modify-hiv-art-associated-myocardial-steatosis-and-hepatic-steatosis
#20
Shenghan Lai, Gary Gerstenblith, Richard D Moore, David D Celentano, David A Bluemke, Glenn Treisman, Chia-Ying Liu, Ji Li, Shaoguang Chen, Thomas Kickler, Hong Lai
BACKGROUND: It has been recognized that myocardial and hepatic steatosis may be more prevalent in HIV-infected individuals on antiretroviral therapy (ART); however, factors associated with these conditions have not been thoroughly investigated. The goals of this study were (1) to identify the risk factors for myocardial and hepatic steatosis in HIV-infected African Americans (AAs) and explore whether ART use is independently associated with myocardial and hepatic steatosis, and (2) to examine whether and how cocaine use influences any associations of ART use with myocardial and hepatic steatosis...
May 26, 2017: Drug and Alcohol Dependence
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