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https://www.readbyqxmd.com/read/28076376/increased-natural-killer-cell-activation-in-hiv-infected-immunologic-non-responders-correlates-with-cd4-t-cell-recovery-after-antiretroviral-therapy-and-viral-suppression
#1
Zhenwu Luo, Zhen Li, Lisa Martin, Zhiliang Hu, Hao Wu, Zhuang Wan, Michael Kilby, Sonya L Heath, Lei Huang, Wei Jiang
The role of natural killer (NK) cell function in HIV disease especially in the setting of long-term antiretroviral therapy (ART) and viral suppression is not fully understood. In the current study, we have investigated NK cell activation in healthy controls and aviremic ART-treated HIV+ subjects with different degrees of immune restoration. We performed a cross sectional study in 12 healthy controls and 24 aviremic ART-treated HIV-infected subjects including 13 HIV+ subjects with CD4+ T cells above 500 cells/μL defined as "immunologic responders" and 11 HIV+ subjects with CD4+ T cells below 350 cells/μL defined as "immunologic non-responders"...
2017: PloS One
https://www.readbyqxmd.com/read/28068675/nutrition-habits-and-health-outcomes-of-breastfeeding-hiv-positive-mothers-in-the-dschang-health-district-west-region-cameroon
#2
Martin Sanou Sobze, Tsi Kien-Atsu, Bruna Djeunang Dongho, Jimmy Roger Fotso, Armand TiotsiaTsapi, Yannick Azeufack Ngueko, Sali Ben Bechir, Augusto Pana, Lucia Ercoli, Vittorio Colizzi, Gianluca Russo
BACKGROUND: Amongst the different at-risk periods for mother-to-child HIV transmission that is, during pregnancy, labor and delivery and breastfeeding, much care and attention needs to be given, not only to the child as concerns its feeding options, but also to the mother. The aim of this study was to determine the nutritional habits and health outcomes of HIV-positive breastfeeding mothers in the Dschang Health District, in the context of prevention of mother-to-child transmission (PMTCT) activities...
September 2016: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/28061822/cardiovascular-risk-and-endothelial-function-in-people-living-with-hiv-aids-design-of-the-multi-site-longitudinal-endoafrica-study-in-the-western-cape-province-of-south-africa
#3
Hans Strijdom, Patrick De Boever, Gerhard Walzl, M Faadiel Essop, Tim S Nawrot, Ingrid Webster, Corli Westcott, Nyiko Mashele, Frans Everson, Stephanus T Malherbe, Kim Stanley, Harald H Kessler, Evelyn Stelzl, Nandu Goswami
BACKGROUND: There is growing evidence of an interaction between HIV-infection, anti-retroviral therapy (ART) and cardiovascular diseases (CVD). Epidemiological studies in Europe and North America have been observing a shift towards an increased incidence of coronary heart disease and acute myocardial infarctions in HIV-infected populations compared to the general population even after adjusting for traditional cardiovascular risk factors. Despite South Africa (and sub-Saharan Africa, SSA) being regarded as the epicentre of the global HIV epidemic, very little is known about the prevalence of cardiovascular risk factors and precursors of vascular disease in HIV-infected populations in this region...
January 7, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28060042/hiv-infected-children-in-malawi-have-decreased-performance-on-the-6-minute-walk-test-with-preserved-cardiac-mechanics-regardless-of-antiretroviral-treatment-status
#4
Amy Sims Sanyahumbi, Mina Hosseinipour, Danielle Guffey, Irving Hoffman, Peter N Kazembe, Madeline McCrary, Charles G Minard, Charles Van der Horst, Craig A Sable
INTRODUCTION: We aimed to (1) determine if cardiac disease can be detected in HIV-infected children by strain imaging, and (2) to evaluate differences in exercise performance between HIVinfected on and not yet on antiretroviral therapy (ART) and in HIV-uninfected children by 6- minute walk tests (6MWT) METHODS:: This cross-sectional study evaluated cardiac function by echocardiogram and exercise performance by 6MWT in HIV-infected and uninfected children ages 4 to 18 years in Lilongwe, Malawi...
January 3, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28053917/mortality-among-pulmonary-tuberculosis-and-hiv-1-co-infected-nigerian-children-being-treated-for-pulmonary-tuberculosis-and-on-antiretroviral-therapy-a-retrospective-cohort-study
#5
Augustine O Ebonyi, Stephen Oguche, Oche O Agbaji, Atiene S Sagay, Prosper I Okonkwo, John A Idoko, Phyllis J Kanki
BACKGROUND: Mortality data, including the risk factors for mortality in HIV-infected children with pulmonary TB (PTB) being treated for PTB and who are on antiretroviral therapy (ART), are scarce in Nigeria. We determined the mortality rate and risk factors for mortality among such children, at the pediatric HIV clinic of the Jos University Teaching Hospital (JUTH) in Jos, Nigeria. METHODS: We performed a retrospective cohort study on 260 PTB-HIV-1 co-infected children, aged 2 months to 13 years, being treated for PTB and on ART from July 2005 to March 2013...
December 2016: Germs
https://www.readbyqxmd.com/read/28049604/evaluating-tumour-after-care-in-oral-squamous-cell-carcinoma-insights-into-patients-health-related-quality-of-life
#6
Oliver Bissinger, Andrea Rau, Steffen Koerdt, Klaus-Dietrich Wolff, Marco Rainer Kesting, Carolin Götz
INTRODUCTION: Tumour aftercare (tac) is an essential tool in oncology. The main aim of these follow ups is to diagnose recurrence and second tumours from the beginning. Tac appointments can create a special environment for patients' further concerns. The purpose of the current study was to evaluate tac of patients diagnosed with OSCC and to investigate their health related quality of life (hrql). MATERIAL AND METHODS: A German questionnaire was created by two maxillo-facial surgeons with several years of tac experience...
December 9, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28048912/th-ef-brb-07-novel-hardware-and-software-platform-for-intermediate-energy-4%C3%AF-radiotherapy
#7
K Woods, M Harrison, S Boucher, J McNevin, S Kutsaev, L Faillace, K Sheng
PURPOSE: To develop a robust and efficient platform for the optimization and robotic delivery of highly noncoplanar intensity modulated radiotherapy, which enables significant reduction of normal tissue toxicity and escalation of tumor dose. METHODS: An innovative high-output compact 3 MV linac was designed for mounting onto a commercial robotic system in order to access the entire 4π beam solution space without moving the patient couch. The use of intermediate energy X-rays for radiotherapy was evaluated in comparison to clinical plans delivered using 6 MV X-rays and a state-of-the-art delivery system...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048582/th-ab-brb-03-4n-radiotherapy
#8
K Sheng
: Current state-of-the art digital C-arm medical linear accelerators are capable of delivering radiation treatments with high level of automation, which affords coordinated motions of gantry, couch, and multileaf collimator (MLC) with dose rate modulations. The new machine capacity has shown the potential to bring substantially improved radiation dosimetry and/or delivery efficiency to many challenging diseases. Combining an integrated beam orientation optimization algorithm with automated machine navigation, markedly improved dose conformity has been achieved using 4ρ therapy...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048560/tu-h-campus-jep1-04-deformable-image-registration-performances-in-pelvis-patients-impact-of-cbct-image-quality
#9
M Fusella, G Loi, C Fiandra, E Lanzi
PURPOSE: To investigate the accuracy and robustness, against image noise and artifacts (typical of CBCT images), of a commercial algorithm for deformable image registration (DIR), to propagate regions of interest (ROIs) in computational phantoms based on real prostate patient images. METHODS: The Anaconda DIR algorithm, implemented in RayStation was tested. Two specific Deformation Vector Fields (DVFs) were applied to the reference data set (CTref) using the ImSimQA software, obtaining two deformed CTs...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048500/we-h-202-04-advanced-medical-image-registration-techniques
#10
G Christensen
: Deformable image registration has now been commercially available for several years, with solid performance in a number of sites and for several applications including contour and dose mapping. However, more complex applications have arisen, such as assessing response to radiation therapy over time, registering images pre- and post-surgery, and auto-segmentation from atlases. These applications require innovative registration algorithms to achieve accurate alignment. The goal of this session is to highlight emerging registration technology and these new applications...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048412/su-c-202-03-a-tool-for-automatic-calculation-of-delivered-dose-variation-for-off-line-adaptive-therapy-using-cone-beam-ct
#11
B Zhang, S Lee, S Chen, J Zhou, K Prado, W D'Souza, B Yi
PURPOSE: Monitoring the delivered dose is an important task for the adaptive radiotherapy (ART) and for determining time to re-plan. A software tool which enables automatic delivered dose calculation using cone-beam CT (CBCT) has been developed and tested. METHODS: The tool consists of four components: a CBCT Colleting Module (CCM), a Plan Registration Moduel (PRM), a Dose Calculation Module (DCM), and an Evaluation and Action Module (EAM). The CCM is triggered periodically (e...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048394/we-h-202-00-session-in-memory-of-jean-pouliot-next-generation-deformable-image-registration
#12
Geoffrey Hugo
: Deformable image registration has now been commercially available for several years, with solid performance in a number of sites and for several applications including contour and dose mapping. However, more complex applications have arisen, such as assessing response to radiation therapy over time, registering images pre- and post-surgery, and auto-segmentation from atlases. These applications require innovative registration algorithms to achieve accurate alignment. The goal of this session is to highlight emerging registration technology and these new applications...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047855/th-ab-brb-00-research-opportunities-with-digital-linear-accelerators
#13
Ke Sheng
: Current state-of-the art digital C-arm medical linear accelerators are capable of delivering radiation treatments with high level of automation, which affords coordinated motions of gantry, couch, and multileaf collimator (MLC) with dose rate modulations. The new machine capacity has shown the potential to bring substantially improved radiation dosimetry and/or delivery efficiency to many challenging diseases. Combining an integrated beam orientation optimization algorithm with automated machine navigation, markedly improved dose conformity has been achieved using 4ρ therapy...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047834/su-c-bra-04-automated-segmentation-of-head-and-neck-ct-images-for-radiotherapy-treatment-planning-via-multi-atlas-machine-learning-maml
#14
X Ren, G Sharp, H Gao
PURPOSE: Accurate image segmentation is a crucial step during image guided radiation therapy. This work proposes multi-atlas machine learning (MAML) algorithm for automated segmentation of head-and-neck CT images. METHODS: As the first step, the algorithm utilizes normalized mutual information as similarity metric, affine registration combined with multiresolution B-Spline registration, and then fuses together using the label fusion strategy via Plastimatch. As the second step, the following feature selection strategy is proposed to extract five feature components from reference or atlas images: intensity (I), distance map (D), box (B), center of gravity (C) and stable point (S)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047810/su-f-t-592-a-delivery-qa-free-approach-for-adaptive-therapy-of-prostate-cancer-with-static-intensity-modulated-radiotherapy
#15
T Roth, J Dooley, T Zhu, R Woods, P Mavroidis, J Lian
PURPOSE: Clinical implementations of adaptive radiotherapy (ART) are limited mainly by the requirement of delivery QA (DQA) prior to the treatment. Small segment size and small segment MU are two dominant factors causing failures of DQA. The aim of this project is to explore the feasibility of ART treatment without DQA by using a partial optimization approach. METHODS: A retrospective simulation study was performed on two prostate cancer patients treated with SMLC-IMRT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047749/we-h-202-01-memorial-introduction
#16
N Kirby
: Deformable image registration has now been commercially available for several years, with solid performance in a number of sites and for several applications including contour and dose mapping. However, more complex applications have arisen, such as assessing response to radiation therapy over time, registering images pre- and post-surgery, and auto-segmentation from atlases. These applications require innovative registration algorithms to achieve accurate alignment. The goal of this session is to highlight emerging registration technology and these new applications...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047420/su-f-j-57-effectiveness-of-daily-ct-based-three-dimensional-image-guided-and-adaptive-proton-therapy
#17
S Moriya, H Tachibana, K Hotta, N Nakamura, H Baba, R Kohno, S Miyakawa, T Kurosawa, T Akimoto
PURPOSE: Daily CT-based three-dimensional image-guided and adaptive (CTIGRT-ART) proton therapy system was designed and developed. We also evaluated the effectiveness of the CTIGRT-ART. METHODS: Retrospective analysis was performed in three lung cancer patients: Proton treatment planning was performed using CT image datasets acquired by Toshiba Aquilion ONE. Planning target volume and surrounding organs were contoured by a well-trained radiation oncologist. Dose distribution was optimized using 180-deg...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047385/mo-e-brc-02-mri-guided-online-adaptive-radiotherapy-the-ucla-approach-to-quality-management
#18
J Lamb
: Online adaptive radiation therapy has the potential to ensure delivery of optimal treatment to the patient by accounting for anatomical and potentially functional changes that occur from one fraction to the next and over the course of treatment. While on-line adaptive RT (ART) has been a topic of many publications, discussions, and research, it has until very recently remained largely a concept and not a practical implementation. However, recent advances in on-table imaging, use of deformable image registration for contour generation and dose tracking, faster and more efficient plan optimization, as well as fast quality assurance method has enabled the implementation of ART in the clinic in the past couple of years...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047193/th-ab-brb-01-trajectory-modulated-arc-therapy-application-to-partial-breast-irradiation
#19
D Hristov
: Current state-of-the art digital C-arm medical linear accelerators are capable of delivering radiation treatments with high level of automation, which affords coordinated motions of gantry, couch, and multileaf collimator (MLC) with dose rate modulations. The new machine capacity has shown the potential to bring substantially improved radiation dosimetry and/or delivery efficiency to many challenging diseases. Combining an integrated beam orientation optimization algorithm with automated machine navigation, markedly improved dose conformity has been achieved using 4ρ therapy...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047096/we-h-202-02-biomechanical-modeling-of-anatomical-response-over-the-course-of-therapy
#20
K Brock
: Deformable image registration has now been commercially available for several years, with solid performance in a number of sites and for several applications including contour and dose mapping. However, more complex applications have arisen, such as assessing response to radiation therapy over time, registering images pre- and post-surgery, and auto-segmentation from atlases. These applications require innovative registration algorithms to achieve accurate alignment. The goal of this session is to highlight emerging registration technology and these new applications...
June 2016: Medical Physics
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