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https://www.readbyqxmd.com/read/29663899/hiv-1-drug-resistance-profiles-for-the-hiv-protease-and-reverse-transcriptase-gene-in-patients-receiving-combination-therapy-in-tehran-iran
#1
Leila Sadeghi, Mahin Lolaie, Reza Adl Tabatabai, Saeed Bayanolhagh, Leila Taj, Niloofar Eghbal Ahmadi, Negin Abedinzadeh, Farzaneh Vakili, Ghazaleh Ahmadi, Minoo Mohraz
BACKGROUND: Determination of drug resistant mutations has a crucial role in the management of HIV-1 infected patients. OBJECTIVE: The aim of the current study was to evaluate drug resistance profile of RT and PR gene, and find the correlation between drug resistance mutation and ART regimen to intensify physicians ' options for the most effective therapy and help to establish health related policies at the national level in Iran. METHOD: HIV-1 RNA of 34 samples was extracted from plasma and RT Nested- PCR was performed and the final products were sequenced...
April 15, 2018: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/29661246/risk-factors-and-outcomes-for-the-q151m-and-t69-insertion-hiv-1-resistance-mutations-in-historic-uk-data
#2
Oliver T Stirrup, David T Dunn, Anna Tostevin, Caroline A Sabin, Anton Pozniak, David Asboe, Alison Cox, Chloe Orkin, Fabiola Martin, Patricia Cane
BACKGROUND: The prevalence of HIV-1 resistance to antiretroviral therapies (ART) has declined in high-income countries over recent years, but drug resistance remains a substantial concern in many low and middle-income countries. The Q151M and T69 insertion (T69i) resistance mutations in the viral reverse transcriptase gene can reduce susceptibility to all nucleoside/tide analogue reverse transcriptase inhibitors, motivating the present study to investigate the risk factors and outcomes associated with these mutations...
April 16, 2018: AIDS Research and Therapy
https://www.readbyqxmd.com/read/29659605/chronic-kidney-disease-in-the-global-adult-hiv-infected-population-a-systematic-review-and-meta-analysis
#3
Udeme E Ekrikpo, Andre P Kengne, Aminu K Bello, Emmanuel E Effa, Jean Jacques Noubiap, Babatunde L Salako, Brian L Rayner, Giuseppe Remuzzi, Ikechi G Okpechi
INTRODUCTION: The widespread use of antiretroviral therapies (ART) has increased life expectancy in HIV patients, predisposing them to chronic non-communicable diseases including Chronic Kidney Disease (CKD). We performed a systematic review and meta-analysis (PROSPERO registration number CRD42016036246) to determine the global and regional prevalence of CKD in HIV patients. METHODS: We searched PubMed, Web of Science, EBSCO and AJOL for articles published between January 1982 and May 2016...
2018: PloS One
https://www.readbyqxmd.com/read/29656588/the-use-of-funnel-plots-with-regression-as-a-tool-to-visually-compare-hiv-treatment-outcomes-between-centres-adjusting-for-patient-characteristics-and-size-a-uk-collaborative-hiv-cohort-study
#4
M Gompels, S Michael, S Jose, T Hill, R Trevelion, C A Sabin, M T May
OBJECTIVES: A measure used for assessing the effectiveness of HIV care and comparing clinical centres is the proportion of people starting antiretroviral therapy (ART) with viral suppression (VS) after 1 year. We propose a method that adjusts for patients' demographic characteristics, and visually compares this measure between different sites accounting for centre size. METHODS: We analysed viral load measurements for UK Collaborative HIV Cohort (UK CHIC) patients starting ART between 2006 and 2013...
April 14, 2018: HIV Medicine
https://www.readbyqxmd.com/read/29628513/hot-news-impact-of-low-level-viremia-on-treatment-outcomes-during-art-is-it-time-to-revise-the-definition-of-virological-failure
#5
Eva Poveda, Manuel Crespo
The level of HIV-RNA in plasma (HIV viral load) is the main marker used to monitor the virological response to antiretroviral therapy (ART) in HIV-infected patients. The threshold used to define virological suppression has historically been dictated by the limits of detection of the commercial assays used to quantify the plasma viral load. Thus, as more sensitive assays have proliferated and become more widely available, the definition has shifted from < 400 cop/mL with the first generation assays, to < 50 cop/mL, to < 20 cop/mL currently...
January 2018: AIDS Reviews
https://www.readbyqxmd.com/read/29616646/morbidity-and-mortality-in-hiv-infected-children-on-antiretroviral-therapy-in-togo
#6
A Mouhari-Touré, G Mahamadou, K Kombate, A S Akakpo, J N Teclessou, A Singo, P Pitché
the aim of this study was to evaluate the mortality and morbidity of HIV-infected children on highly active antiretroviral treatment (HAART) in Togo. this is a retrospective study of HIV-infected children on HAART in the 25 largest centers of HIV/AIDS care in Togo. the study included 1861 children (sex-ratio=0.99). Among them, 35.6 % were in WHO clinical stages 3 or 4 at the beginning of HAART. The most common opportunistic infections were coughing and pneumonia (37.1 %), gastroenteritis (11.3 %), various bacterial infections (10...
February 1, 2018: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29616311/serum-levels-of-pentraxin-3-differ-significantly-at-the-time-of-blastocyst-transfer-depending-on-implantation-success-a-pilot-study
#7
Alexander Freis, Kyra Von Horn, Tamara Göggl, Stephanie Hecht, Sabine Roesner, Thomas Strowitzki, Ariane Germeyer
OBJECTIVE: Many approaches try to identify the underlying molecular mechanisms to detect new potential biomarkers for successful artificial reproductive therapies. One factor has been described as a possible regulator of inflammation during implantation: Pentraxin 3 (PTX3), which seems to be essential for female fertility on one hand, but whose overexpression has been described in many obstetric complications based on abnormal placentation on the other hand. Therefore, we investigated if serum levels of PTX3 at the time of embryo transfer differ between women with an ongoing pregnancy compared to those without implantation...
April 3, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29603514/sexual-acquisition-of-hiv-infection-after-solid-organ-transplantation-late-presentation-and-potentially-fatal-complications
#8
M P Cristelli, M A Mazolin, C Manzardo, M S J Ribeiro, F Cofán, D W C Santos, M A Castel, H Tedesco-Silva, A Moreno, F Diekman, J M Miro, J O Medina-Pestana
INTRODUCTION: While the growing knowledge on HIV among solid organ transplant recipients (SOT) is limited to either pretransplant infection or allograft transmission, there are only sparse reports describing HIV-infection after transplantation through sexual route, the primary mode of transmission in the general population. METHODS: From two different centers, we report nine new cases of HIV infection in SOT recipients attributed to sexual acquisition: eight cases of kidney-transplant recipients and one heart-transplant recipient...
March 30, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29602141/is-thromboprophylaxis-cost-effective-in-ovarian-hyperstimulation-syndrome-a-systematic-review-and-cost-analysis
#9
REVIEW
Kelly Comerford Wormer, Ayesha A Jangda, Farah A El Sayed, Katherine I Stewart, Sunni L Mumford, James H Segars
BACKGROUND: The majority of serious thromboembolic events occurring in assisted reproductive technologies (ART) are in women with ovarian hyperstimulation syndrome (OHSS). OBJECTIVES: The purpose of this study was to present a thorough review and cost analysis regarding the use of venous thromboembolism (VTE) prophylaxis in OHSS to inform clinical management. DATA SOURCES: Databases used were Pubmed and Embase, in addition to checking reference lists of retrieved articles (inception to November 2017)...
March 19, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29594674/child-art-psychotherapy-in-camhs-in-ireland-a-parent-satisfaction-study
#10
Ezgi Tanıl, Aynur Coşkunlu, Aisling Mulligan
OBJECTIVES: We aimed to evaluate parent satisfaction with the Vasarhelyi method of Child Art Psychotherapy offered at two Child and Adolescent Mental Health teams by postal survey using the Client Satisfaction Questionnaire, and by performing a qualitative interview. METHODS: Parents of 29 children who attended Child Art Psychotherapy over the previous 4 years were invited to participate-they were sent the Client Satisfaction Questionnaire and invited to attend for an interview about Child Art Psychotherapy...
March 29, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29593675/cryptococcal-antigen-screening-in-asymptomatic-hiv-infected-antiretroviral-na%C3%A3-ve-patients-in-cameroon-and-evaluation-of-the-new-semi-quantitative-biosynex-cryptops-test
#11
Elvis Temfack, Charles Kouanfack, Leonella Mossiang, Angela Loyse, Marie C Fonkoua, Síle F Molloy, Sinata Koulla-Shiro, Eric Delaporte, Françoise Dromer, Thomas Harrison, Olivier Lortholary
Background: Cryptococcal meningitis (CM) is a major cause of AIDS-related mortality in Africa. Detection of serum cryptococcal antigen (CrAg) predicts development of CM in antiretroviral (ART) naïve HIV-infected patients with severe immune depression. Systematic pre-ART CrAg screening and pre-emptive oral fluconazole is thus recommended. We postulated that a semi-quantitative CrAg screening approach could offer clinically relevant advantages. Methods: ART-naïve asymptomatic adult outpatients with <100 CD4 cells/mm3 presenting to the Yaoundé Central Hospital, Cameroon were screened for CrAg using the IMMY lateral flow assay (LFA)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29593048/effect-of-short-term-art-interruption-on-levels-of-integrated-hiv-dna
#12
Zachary Strongin, Radwa Sharaf, D Jake VanBelzen, Jeffrey M Jacobson, Elizabeth Connick, Paul Volberding, Daniel J Skiest, Rajesh T Gandhi, Daniel R Kuritzkes, Una O'Doherty, Jonathan Z Li
Analytic treatment interruption (ATI) studies are required to evaluate strategies aimed at achieving ART-free HIV remission, but the impact of ATI on the viral reservoir remains unclear. We validated a DNA size selection-based assay for measuring levels of integrated HIV DNA and applied it to assess the effects of short-term ATI on the HIV reservoir. Samples from participants from four AIDS Clinical Trials Group (ACTG) ATI studies were assayed for integrated HIV DNA levels. Cryopreserved PBMCs were obtained for 12 participants with available samples pre-ATI and approximately 6 months after ART resumption...
March 28, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29589465/genotypic-characterization-of-hiv-1-prevalent-in-kepulauan-riau-indonesia
#13
Siti Qamariyah Khairunisa, Shuhei Ueda, Adiana Mutamsari Witaningrum, Muhammad Qushai Yunifiar M, Dwi Wahyu Indriati, Tomohiro Kotaki, Nasronudin Nasronudin, Masanori Kameoka
Kepulauan Riau is a famous tourist destination in Indonesia. The epidemic of human immunodeficiency virus type 1 (HIV-1) infection is gradually increasing in this region. We collected peripheral blood samples from 62 antiretroviral therapy (ART)-experienced individuals. The amplification of viral genomic fragments, HIV-1 subtyping, and the detection of HIV drug resistance (HIVDR) were performed. Viral subtyping revealed that the most prevalent HIV-1 subtype/circulating recombinant form (CRF) was CRF01_AE (55...
March 28, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29588457/efficacy-and-safety-of-boosted-darunavir-based-antiretroviral-therapy-in-hiv-1-positive-patients-results-from-a-meta-analysis-of-clinical-trials
#14
A Antinori, A Lazzarin, A Uglietti, M Palma, D Mancusi, R Termini
Darunavir/ritonavir (DRV/r) is a second-generation protease inhibitor used in treatment-naïve and -experienced HIV-positive adult patients. To evaluate efficacy and safety in these patient settings, we performed a meta-analysis of randomized controlled trials. We considered eight studies involving 4240 antiretroviral treatment (ART)-naïve patients and 14 studies involving 2684 ART-experienced patients. Regarding efficacy in the ART-naive patients, the virological response rate was not significantly different between DRV/r and the comparator...
March 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29566096/predicting-short-term-interruptions-of-antiretroviral-therapy-from-summary-adherence-data-development-and-test-of-a-probability-model
#15
Rebecca Arden Harris, Jessica E Haberer, Nicholas Musinguzi, Kyong-Mi Chang, Clyde B Schechter, Chyke A Doubeni, Robert Gross
Antiretroviral therapy (ART) for HIV is vulnerable to unplanned treatment interruptions-consecutively missed doses over a series of days-which can result in virologic rebound. Yet clinicians lack a simple, valid method for estimating the risk of interruptions. If the likelihood of ART interruption could be derived from a convenient-to-gather summary measure of medication adherence, it might be a valuable tool for both clinical decision-making and research. We constructed an a priori probability model of ART interruption based on average adherence and tested its predictions using data collected on 185 HIV-infected, treatment-naïve individuals over the first 90 days of ART in a prospective cohort study in Mbarara, Uganda...
2018: PloS One
https://www.readbyqxmd.com/read/29564158/delivering-comprehensive-hiv-services-across-the-hiv-care-continuum-a-comparative-analysis-of-survival-and-progress-towards-90-90-90-in-rural-malawi
#16
Emily B Wroe, Elizabeth L Dunbar, Noel Kalanga, Luckson Dullie, Chiyembekezo Kachimanga, Andrew Mganga, Michael Herce, Jason Beste, Jonas Rigodon, Lawrence Nazimera, Ryan K McBain
Introduction: Partners In Health and the Malawi Ministry of Health collaborate on comprehensive HIV services in Neno, Malawi, featuring community health workers, interventions addressing social determinants of health and health systems strengthening. We conducted an observational study to describe the HIV care continuum in Neno and to compare facility-level HIV outcomes against health facilities nationally. Methods: We compared facility-level outcomes in Neno (n=13) with all other districts (n=682) from 2013 to 2015 using mixed-effects linear regression modelling...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29561311/cardiac-magnetic-resonance-imaging-and-primary-prevention-implantable-cardioverter-defibrillator-therapy-current-recommendations-and-future-directions
#17
Andrea I Guaricci, Delia De Santis, Mark G Rabbat, Gianluca Pontone
: Implantable cardioverter defibrillators (ICDs) have proven to be the most effective preventive therapy of sudden cardiac death (SCD). Based on current guidelines, the indication for prophylactic ICD therapy is primarily based on a left ventricular ejection fraction (LVEF) less than 35%. However, patients with low LVEF may never have an arrhythmic event while patients with normal to moderately reduced LVEF, who are traditionally felt to be at lower risk, can experience SCD. Therefore, LVEF alone is not an ideal risk stratification parameter to determine ICD therapy...
May 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29560824/in-silico-drug-combination-discovery-for-personalized-cancer-therapy
#18
Minji Jeon, Sunkyu Kim, Sungjoon Park, Heewon Lee, Jaewoo Kang
BACKGROUND: Drug combination therapy, which is considered as an alternative to single drug therapy, can potentially reduce resistance and toxicity, and have synergistic efficacy. As drug combination therapies are widely used in the clinic for hypertension, asthma, and AIDS, they have also been proposed for the treatment of cancer. However, it is difficult to select and experimentally evaluate effective combinations because not only is the number of cancer drug combinations extremely large but also the effectiveness of drug combinations varies depending on the genetic variation of cancer patients...
March 19, 2018: BMC Systems Biology
https://www.readbyqxmd.com/read/29560714/artemisinin-and-aiegen-conjugate-for-mitochondria-targeted-and-image-guided-chemo-and-photodynamic-cancer-cell-ablation
#19
Guangxue Feng, Jie Liu, Chong-Jing Zhang, Bin Liu
Cell organelle targeting is a promising approach for cancer therapy. Herein, we report a mitochondria-targeted light-up probe (TPETH-Mito-1ART) to co-deliver artemisinin (ART) and an AIE photosensitizer (PS) to mitochondria for image-guided combination cancer cell ablation. This probe contains an AIEgen core of TPETH, two mitochondria targeting arms with ART on one arm, which could be internalized into cancer cells over normal ones, and show predominant accumulation and fluorescence turn-on in mitochondria...
March 21, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29557433/advances-in-liquid-metals-for-biomedical-applications
#20
Junjie Yan, Yue Lu, Guojun Chen, Min Yang, Zhen Gu
To date, liquid metals have been widely applied in many fields such as electronics, mechanical engineering and energy. In the last decade, with a better understanding of the physicochemical properties such as low viscosity, good fluidity, high thermal/electrical conductivity and good biocompatibility, gallium and gallium-based low-melting-point (near or below physiological temperature) alloys have attracted considerable attention in bio-related applications. This tutorial review introduces the common performances of liquid metals, highlights their featured properties, as well as summarizes various state-of-the-art bio-applications involving carriers for drug delivery, molecular imaging, cancer therapy and biomedical devices...
March 20, 2018: Chemical Society Reviews
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