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https://www.readbyqxmd.com/read/27920998/short-term-organ-culture-of-mouse-ovary-in-the-medium-supplemented-with-bone-morphogenetic-protein-15-and-follicle-stimulating-hormone-a-morphological-hormonal-and-molecular-study
#1
Mojdeh Salehnia, Mojdeh Pajokh, Nassim Ghorbanmehr
BACKGROUND: Bone morphogenetic protein 15 (BMP15) is a growth factor derived from oocyte and is essential for in vivo ovarian follicular growth and in this study, its effects on the improvement of growth and development of follicles during in vitro culture of neonatal mouse ovaries was investigated. METHODS: Two week old mice were cultured for 7 days in the basic culture media with or without follicle stimulating hormone (FSH) and BMP15 as four experimental groups; FSH(-)/BMP15(-), FSH(+)/BMP15(-), FSH(-)/BMP15(+) and FSH(+)/BMP15(+)...
October 2016: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/27920883/exogenous-secreted-frizzled-related-protein-4-modulates-steroidogenesis-of-rat-granulosa-cells-through-wnt-%C3%AE-catenin-and-pi3k-akt-signaling-pathways
#2
Ghamartaj Hossein, Manijeh Khanmohammadi, Parisa Sahranavard Fard, Yasaman Heidarian, Somaieh Kazemnejad, Mohammad Mehdi Akhondi
BACKGROUND: It has been reported that secreted frizzled-related protein-4 known as an antagonist of Wnt signaling pathway plays a role in luteinization process of rodent granulosa cells. The purpose of this study was twofold: 1) to determine whether recombinant human secreted frizzled-related protein-4 (rhSFRP-4) could directly induce terminal differentiation of rat Granulosa Cells (GCs) and 2) to understand how the modulation of β-catenin and Protein Kinase B (PKB)/AKT activity by exogenous SFRP-4 could be involved in steroidogenesis...
October 2016: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/27920855/aggressive-angiomyxoma-case-report-and-review-of-the-literature
#3
John C Benson, Scott Gilles, Tina Sanghvi, James Boyum, Eric Niendorf
A 47-year-old female presented to clinic with a 5-year history of a left buttock mass. The patient's hemoglobin was low (9.7 g/dL); laboratory analysis was otherwise unremarkable. Ultrasound of the left gluteal region demonstrated a heterogeneous vascular solid lesion. Magnetic resonance and computed tomography imaging showed an enhancing mass extending from the left ischioanal fossa through the levator ani muscle into the pelvis. Biopsy revealed bland-appearing spindle-shaped cells positive for estrogen and progesterone receptors, consistent with an aggressive angiomyxoma...
December 2016: Radiology case reports
https://www.readbyqxmd.com/read/27920630/bilateral-diffuse-pseudoangiomatous-stromal-hyperplasia-pash-causing-gigantomastia-in-a-33-year-old-pregnant-woman-case-report
#4
Natalia Krawczyk, Tanja Fehm, Eugen Ruckhäberle, Svjetlana Mohrmann, Jasmin Riemer, Stefan Braunstein, Jürgen Hoffmann
Pseudoangiomatous stromal hyperplasia (PASH) is a benign proliferation of mammary stroma mostly described as an incidental microscopic finding. Clinically, it can manifest as a palpable, well-circumscribed breast mass or in rare cases as a diffuse bilateral process causing massive breast enlargement. The most postulated theory for aetiology of this condition is hormonal stimulation of mammary myofibroblasts, particularly by progesterone. A definite diagnosis of PASH is based on typical pathological findings like stromal hyperplasia and empty slit-like channels positive for myofibroblastic and negative for endothelial markers...
October 2016: Breast Care
https://www.readbyqxmd.com/read/27919975/long-term-high-quality-survival-with-single-agent-mifepristone-treatment-despite-advanced-cancer
#5
Jerome H Check, Diane Check, Carrie Wilson, Patrice Lofberg
CASE REPORT: We show long-term high-quality survival following single-agent treatment with a progesterone receptor antagonist in two cases of advanced metastatic cancer. Because no biopsy was performed (patient refused) the exact type of lung cancer was not determined but the majority of oncologists who evaluated the patient thought that the rapid onset and syndrome of inappropriate anti-diuretic hormone was more consistent with small-cell lung cancer. The US Food and Drug Association granted a compassionate-use investigational new drug approval for use of single-agent 200 mg mifepristone orally/day to a moribund woman with never-treated metastatic lung cancer and a male with bilateral renal cell carcinoma who had undergone only a unilateral hemi-nephrectomy...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27919946/in-vivo-selection-of-intermediately-and-highly-malignant-variants-of-triple-negative-breast-cancer-in-orthotopic-nude-mouse-models
#6
Shuya Yano, Kiyoto Takehara, Hiroyuki Kishimoto, Hiroshi Tazawa, Yasuo Urata, Shunsuke Kagawa, Michael Bouvet, Toshiyoshi Fujiwara, Robert M Hoffman
AIM: Triple-negative breast cancer (TNBC), defined by the absence of receptors for estrogen, progesterone and human epithelial receptor 2 (HER2), is a recalcitrant disease in need of effective therapy. We previously isolated very-highly metastatic variants of the TNBC cell line MDA-MB-231 using serial orthotopic implantation of MDA-MB-231 human breast cancer cells in nude mice. MATERIALS AND METHODS: MDA-MB-231 cells expressing red fluorescent protein (MDA-MB-231-RFP) (1×10(7) cells/site) were initially injected subcutaneously in the flank of nude mice...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27919641/effect-of-hyperthyroidism-on-circulating-prolactin-and-hypothalamic-expression-of-tyrosine-hydroxylase-prolactin-signaling-cascade-members-and-estrogen-and-progesterone-receptors-during-late-pregnancy-and-lactation-in-the-rat
#7
Gisela E Pennacchio, Flavia J Neira, Marta Soaje, Graciela A Jahn, Susana R Valdez
Hyperthyroidism (HyperT) compromises pregnancy and lactation, hindering suckling-induced PRL release. We studied the effect of HyperT on hypothalamic mRNA (RT-qPCR) and protein (Western blot) expression of tyrosine hydroxylase (TH), PRL receptor (PRLR) and signaling pathway members, estrogen-α (ERα) and progesterone (PR) receptors on late pregnancy (days G19, 20 and 21) and early lactation (L2) in rats. HyperT advanced pre-partum PRL release, reduced circulating PRL on L2 and increased TH mRNA (G21 and L2), p-TH, PRLR mRNA, STAT5 protein (G19 and L2), PRLR protein (G21) and CIS protein (G19)...
December 2, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27919266/arrest-at-the-diplotene-stage-of-meiotic-prophase-i-is-delayed-by-progesterone-but-is-not-required-for-primordial-follicle-formation-in-mice
#8
Sudipta Dutta, Deion M Burks, Melissa E Pepling
BACKGROUND: In mammalian females, reproductive capacity is determined by the size of the primordial follicle pool. During embryogenesis, oogonia divide mitotically but cytokinesis is incomplete so oogonia remain connected in germ cell cysts. Oogonia begin to enter meiosis at 13.5 days postcoitum in the mouse and over several days, oocytes progress through the stages of meiotic prophase I arresting in the diplotene stage. Concurrently, germ cell cysts break apart and individual oocytes become surrounded by granulosa cells forming primordial follicles...
December 5, 2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27918564/interleukin-33-induced-expression-of-pibf1-by-decidual-b-cells-protects-against-preterm-labor
#9
Bihui Huang, Azure N Faucette, Michael D Pawlitz, Bo Pei, Joshua W Goyert, Jordan Zheng Zhou, Nadim G El-Hage, Jie Deng, Jason Lin, Fayi Yao, Robert S Dewar, Japnam S Jassal, Maxwell L Sandberg, Jing Dai, Montserrat Cols, Cong Shen, Lisa A Polin, Ronald A Nichols, Theodore B Jones, Martin H Bluth, Karoline S Puder, Bernard Gonik, Nihar R Nayak, Elizabeth Puscheck, Wei-Zen Wei, Andrea Cerutti, Marco Colonna, Kang Chen
Preterm birth (PTB) is a leading cause of neonatal death worldwide. Intrauterine and systemic infection and inflammation cause 30-40% of spontaneous preterm labor (PTL), which precedes PTB. Although antibody production is a major immune defense mechanism against infection, and B cell dysfunction has been implicated in pregnancy complications associated with PTL, the functions of B cells in pregnancy are not well known. We found that choriodecidua of women undergoing spontaneous PTL harbored functionally altered B cell populations...
December 5, 2016: Nature Medicine
https://www.readbyqxmd.com/read/27918164/-the-possibility-of-using-progesterone-receptor-modulators-in-the-treatment-of-myomas
#10
O Šimetka, J Klát, S Bajsová
OBJECTIVE: To summarize the knowledge about the effect of selective progesterone receptor modulators and their use in the treatment of myomas in women of childbearing age and in perimenopause. DESIGN: Review article. RESULTS: Long-term treatment with ulipristal acetate maximizes its effectiveness, it helps to achieve faster bleeding control and increases the number of pa-tients with fibroid volume reduction of more than 50%. Ulipristal acetate is the most effective drug in the medical treatment of myomas and its use will change the approach to surgical treatment...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27917673/-first-attempts-in-the-introduction-of-cryopreservation-of-ovarian-tissues
#11
Péter Fancsovits, János Urbancsek, László Fónyad, Anna Sebestyén, Gézáné Csorba, Ádám Lehner, Zita Kaszás, János Rigó, Attila Bokor
INTRODUCTION: The oncological treatment may damage ovarian function. To prevent this, it is possible to cryopreserve the ovarian tissue, and to keep the samples for long-term storage. The frozen-thawed tissue could be retransplanted after chemo- or radiotherapy. AIM: The aim of our study was to examine the effect of cryopreservation on the viability of ovarian tissue. METHOD: We analyzed the survival of frozen-thawed donated ovarian tissues...
December 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27917511/evidence-for-direct-effects-of-glyphosate-on-ovarian-function-glyphosate-influences-steroidogenesis-and-proliferation-of-bovine-granulosa-but-not-theca-cells-in-vitro
#12
Maria Chiara Perego, Luis F Schutz, Francesca Caloni, Cristina Cortinovis, Marco Albonico, Leon J Spicer
Glyphosate (GLY) is a common herbicide used worldwide but its effect on ovarian function in mammals is unknown. The aim of this study was to determine the potential endocrine disruptor effects of GLY on ovarian function evaluating cell proliferation, steroidogenesis and gene expression using bovine granulosa cells (GC) and theca cells as in vitro models. GC proliferation was impaired (P < 0.05) after exposure to GLY at 0.5, 1.7 and 5 μg ml(-1) . GC progesterone production was not affected (P ≥ 0...
December 5, 2016: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/27917271/favorable-effects-of-progesterone-on-skin-random-flap-survival-in-rats
#13
Lin Dingsheng, Liu Zengbing, Huang Dong
OBJECTIVES: The aim of this study is to determine the effects of progesterone treatment on the survival of random skin flaps. MATERIALS AND METHODS: McFarlane flaps were established and 40 male rats were randomly assigned to the progesterone-treated as the test group or normal saline-treated as the control group. Progesterone or normal saline (10 mg/kg) was administered intraperitoneally once daily. On postoperative day 2, malondialdehyde (MDA) and superoxide dismutase (SOD) were detected using test kits...
November 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27917104/thirty-eight-year-follow-up-of-two-sibling-lipoid-congenital-adrenal-hyperplasia-patients-due-to-homozygous-steroidogenic-acute-regulatory-stard1-protein-mutation-molecular-structure-and-modeling-of-the-stard1-l275p-mutation
#14
Khalil Khoury, Elie Barbar, Youssef Ainmelk, Annie Ouellet, Pierre Lavigne, Jean-Guy LeHoux
Objective: Review the impact of StAR (STARD1) mutations on steroidogenesis and fertility in LCAH patients. Examine the endocrine mechanisms underlying the pathology of the disorder and the appropriate therapy for promoting fertility and pregnancies. Design: Published data in the literature and a detailed 38-year follow-up of two sibling LCAH patients. Molecular structure and modeling of the STARD1 L275P mutation. Setting: University hospital. Patients: Patient A (46,XY female phenotype) and patient B (46,XX female) with LCAH bearing the L275P mutation in STARD1...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27916114/competitive-inhibition-assay-for-the-detection-of-progesterone-in-dairy-milk-using-a-fiber-optic-spr-biosensor
#15
D Daems, J Lu, F Delport, N Mariën, L Orbie, B Aernouts, I Adriaens, T Huybrechts, W Saeys, D Spasic, J Lammertyn
Analytical methods that are often used for the quantification of progesterone in bovine milk include immunoassays and chromatographic techniques. Depending on the selected method, the main disadvantages are the cost, time-to-result, labor intensity and usability as an automated at-line device. This paper reports for the first time on a robust and practical method to quantify small molecules, such as progesterone, in complex biological samples using an automated fiber optic surface plasmon resonance (FO-SPR) biosensor...
January 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27914766/histomorphological-changes-in-endometriosis-in-a-patient-treated-with-ulipristal-a-case-report
#16
J Bateman, O Bougie, S Singh, S Islam
BACKGROUND: Selective progesterone receptor modulators have shown efficacy in the treatment of endometriosis, however they are not currently licensed in Canada for this purpose. Their histomorphological effects have been well documented in the endometrium, but not in endometriosis. CASE REPORT: The patient presented with uterine fibroids and heavy menstrual bleeding, and was treated with ulipristal acetate over three 90-day courses. She eventually elected to undergo definitive surgical management...
October 25, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27914563/differential-effects-of-testosterone-and-estradiol-on-clitoral-function-an-experimental-study-in-rats
#17
Paolo Comeglio, Ilaria Cellai, Sandra Filippi, Chiara Corno, Francesca Corcetto, Annamaria Morelli, Elena Maneschi, Elisa Maseroli, Edoardo Mannucci, Massimiliano Fambrini, Mario Maggi, Linda Vignozzi
INTRODUCTION: Female sexual response is a complex phenomenon in which psychological, neurologic, and vascular mechanisms and hormonal factors interact. During the arousal phase, they cooperate to increase genital blood flow, thus inducing engorgement of the clitoris and lubrication of the vagina. Regulation of vascular and non-vascular smooth muscle tone is the crucial event in the erectile process. Preclinical studies have suggested that nitric oxide (NO) is the main vasodilator neurotransmitter modulating, through the second messenger cyclic guanosine monophosphate (cGMP), clitoral flow vessels...
December 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27914264/pattern-based-sensing-of-triple-negative-breast-cancer-cells-with-dual-ligand-cofunctionalized-gold-nanoclusters
#18
Yu Tao, Mingqiang Li, Debra T Auguste
Early detection of breast cancer is a critical component in patient prognosis and establishing effective therapy regimens. Here, we developed an easily accessible yet potentially powerful sensor to detect cancer cell targets by utilizing seven dual-ligand cofunctionalized gold nanoclusters (AuNCs) as both effective cell recognition elements and signal transducers. On the basis of this AuNC multichannel sensor, we have successfully distinguished healthy, cancerous and metastatic human breast cells with excellent reproducibility and high sensitivity...
November 25, 2016: Biomaterials
https://www.readbyqxmd.com/read/27912770/endometriosis-associated-clear-cell-carcinoma-arising-in-caesarean-section-scar-a-case-report-and-review-of-the-literature
#19
Gabriella Ferrandina, Eleonora Palluzzi, Francesco Fanfani, Stefano Gentileschi, Anna Lia Valentini, Maria Vittoria Mattoli, Ilaria Pennacchia, Giovanni Scambia, Gianfranco Zannoni
BACKGROUND: Malignant transformation has been reported in approximately 1% of the endometriosis cases; herein, we report a case of clear cell endometrial carcinoma arising from endometriosis foci located within a caesarean section scar. CASE PRESENTATION: In November 2014, a Caucasian, 44-year-old woman was transferred to our institution because of severe respiratory failure due to massive lung embolism and rapid enlargement of a subcutaneous suprapubic mass. Abdomino-pelvic magnetic resonance showed a 10...
December 3, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27911748/actions-of-steroids-new-neurotransmitters
#20
Lauren M Rudolph, Charlotte A Cornil, Melinda A Mittelman-Smith, Jennifer R Rainville, Luke Remage-Healey, Kevin Sinchak, Paul E Micevych
Over the past two decades, the classical understanding of steroid action has been updated to include rapid, membrane-initiated, neurotransmitter-like functions. While steroids were known to function on very short time spans to induce physiological and behavioral changes, the mechanisms by which these changes occur are now becoming more clear. In avian systems, rapid estradiol effects can be mediated via local alterations in aromatase activity, which precisely regulates the temporal and spatial availability of estrogens...
November 9, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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