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https://www.readbyqxmd.com/read/29786517/estrogen-receptor-%C3%AE-potential-target-for-therapy-in-adult-granulosa-cell-tumors
#1
Alessandra Ciucci, Gabriella Ferrandina, Floriana Mascilini, Flavia Filippetti, Giovanni Scambia, Gian Franco Zannoni, Daniela Gallo
OBJECTIVE: Adult granulosa cell tumor (AGCT) is a rare form of sex-cord stromal ovarian tumors. Due to their origin, AGCTs secrete estrogens, and thus, estrogen receptor (ER)-mediated signaling has been considered as a possible target for therapy. The aim of the present study was to get insights into estrogen receptor status and activity in AGCTs, as a strategy to provide molecular support for personalized hormonal treatments. METHODS: We evaluated by immunohistochemistry the expression of ERα, ERβ isoforms (i...
May 18, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29785019/cribriform-morular-variant-of-thyroid-carcinoma-a-neoplasm-with-distinctive-phenotype-associated-with-the-activation-of-the-wnt-%C3%AE-catenin-pathway
#2
REVIEW
José Manuel Cameselle-Teijeiro, Diego Peteiro-González, Javier Caneiro-Gómez, María Sánchez-Ares, Ihab Abdulkader, Catarina Eloy, Miguel Melo, Isabel Amendoeira, Paula Soares, Manuel Sobrinho-Simões
Cribriform-morular variant of thyroid carcinoma is classically associated with familial adenomatous polyposis but, it can also occur as a sporadic neoplasm. This neoplasm is much more frequently observed in women than in men (ratio of 61:1). In familial adenomatous polyposis patients, tumors are generally multifocal and/or bilateral (multinodular appearance), whereas in the sporadic cases tumors tend to occur as single nodules. The tumors are well delimited, and characteristically show a blending of follicular, cribriform, papillary, trabecular, solid, and morular patterns...
May 21, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29784463/anti-m%C3%A3-llerian-hormone-profiling-in-prepubertal-horses-and-its-relationship-with-gonadal-function
#3
Dragos Scarlet, Manuela Wulf, Juliane Kuhl, Martin Köhne, Natascha Ille, Alan J Conley, Christine Aurich
Anti-Müllerian hormone (AMH) has gained increasing interest as a biomarker for assessment of gonadal activity. The ability to predict the ovarian follicular reserve of prepubertal female horses (fillies) or to identify stallions with testicular pathologies already during their prepubertal life has not been analyzed so far. Both would help to select fertile horses and reduce costs associated with keeping animals. The objectives of the present study were to (1) assess AMH, LH, FSH, progesterone (females) and testosterone (males) dynamics in prepubertal horses from birth onwards and (2) determine whether AMH concentrations detected in plasma of prepubertal female and male horses are correlated with postpubertal gonadal development...
May 15, 2018: Theriogenology
https://www.readbyqxmd.com/read/29783884/roles-of-progesterone-receptor-membrane-component-1-in-oxidative-stress-induced-aging-in-chorion-cells
#4
Liping Feng, Terrence K Allen, William P Marinello, Amy P Murtha
INTRODUCTION: Oxidative stress-mediated fetal membrane cell aging is activated prematurely in preterm premature rupture of membranes (PPROMs). The mechanism of this phenomenon is largely understudied. Progesterone receptor membrane component 1 (PGRMC1) has been recognized as a potential protective component for maintaining fetal membrane integrity and healthy pregnancies. We aimed to investigate the effects of oxidative stress (represented by hydrogen peroxide [H2 O2]) on fetal membrane and chorion cell senescence, p38 mitogen-activated protein kinase (MAPK) phosphorylation, and sirtuin 3 (SIRT3) and to examine the roles of PGRMC1 in these effects...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29783652/pituitary-gonadal-thyroid-hormones-and-endocrine-disruptors-in-pre-and-postmenopausal-nigerian-women-with-er-pr-and-her-2-positive-and-negative-breast-cancers
#5
Olulope Ajayi, Mabel Charles-Davies, John Anetor, Adeyinka Ademola
Breast cancer is broadly sub-divided into hormone responsive and non-hormone responsive subtypes. Estradiol has been associated with hormone responsive breast cancers. There is, however, a paucity of information on the role of sex hormones, gonadotropins, and thyroid hormone in non-hormone responsive breast cancer. This study aimed to determine differences in the serum levels of sex hormones, gonadotropins, thyroid hormones, and endocrine disruptors (lead, cadmium, and arsenic) in Nigerian women with hormone responsive and non-hormone responsive breast cancers...
May 18, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29783630/does-molimina-indicate-ovulation-prospective-data-in-a-hormonally-documented-single-cycle-in-spontaneously-menstruating-women
#6
Jerilynn C Prior, Chiaki Konishi, Christine L Hitchcock, Elaine Kingwell, Patti Janssen, Anthony P Cheung, Nichole Fairbrother, Azita Goshtasebi
Approximately 33% of normal-length (21⁻35 days) cycles have subclinical ovulatory disturbances and lack sufficient progesterone, although their normal length ensures enough estrogen. Subclinical ovulatory disturbances are related to significant premenopausal spine bone loss (-0.86%/year). Molimina, non-distressing premenstrual experiences, may detect ovulation within normal-length cycles. This prospective study assessed the relationship between molimina and ovulation. After 1-cycle of daily diary and first morning urine collections, women answered the Molimina Question (MQ): " Can you tell by the way you feel that your period is coming? " and were invited to share (a) predictive premenstrual experience(s)...
May 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29783047/stroma-cell-derived-factor-1-and-connexins-37-and-43-are-preserved-after-vitrification-and-in-vitro-culture-of-goat-ovarian-cortex
#7
Nathalie Jiatsa Donfack, Kele Amaral Alves, Benner Geraldo Alves, Rebeca Magalhães Pedrosa Rocha, Jamily Bezzera Bruno, Marcelo Bertolini, Regiane Rodrigues Dos Santos, Sheyla Farhaydes Souza Domingues, José Ricardo De Figueiredo, Johan Smitz, Ana Paula Ribeiro Rodrigues
This study aimed to evaluate the follicular morphology and development (follicular activation, cell proliferation, and hormone production), as well as the distribution pattern of Connexins 37 and 43 and SDF-1α after vitrification and in vitro culture of goat ovarian tissue. The study involved four experimental groups: fresh control, vitrified control, fresh culture and vitrified culture. The ovarian fragments were vitrified by a solid surface technique using the Ovarian Tissue Cryosystem and subsequently in vitro cultured for 7 days...
May 12, 2018: Theriogenology
https://www.readbyqxmd.com/read/29783037/premature-progesterone-rise-on-day-of-hcg-negatively-correlated-with-live-birth-rate-in-ivf-cycles-an-analysis-of-1-022-cycles
#8
Lepage Julien, Keromnès Gwenola, Sylvie Epelboin, Luton Dominique, Yazbeck Chadi
OBJECTIVE: To investigate the relationship between serum P levels on the day of hCG administration and pregnancy outcomes in patients undergoing IVF. DESIGN: Retrospective study SETTING: Teaching hospital PATIENTS: A total of 1022 IVF-ICSI cycles, frozen embryo transfer excluded INTERVENTION(S):: Patients- all types of responder - underwent IVF with agonist or antagonist protocols. Clinical outcomes of IVF were analyzed according to plasma P levels. MAIN OUTCOME MEASURE(S): Ongoing pregnancy rates...
May 18, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29783035/estrogen-receptor-progesterone-receptor-cd8-expression-in-endometrium-of-women-of-unexplained-infertility
#9
Shilpi Gupta Dixit, Surajit Ghatak, Pratibha Singh, Shilajit Bhattacharya
OBJECTIVE: The present study aimed to investigate the changes of endometrial progesterone and estrogen receptors in luteal phase biopsy specimens of infertile women and find a correlation, if any, between these and CD8+ receptors in the same. METHODS: The study was conducted on luteal phase endometrial biopsy specimens of 30 women of Unexplained Infertility and 15 age matched controls. Paraffin sections were first H & E stained. A standardized immunohistochemical protocol was then used to localize the estrogen, progesterone and CD8+ receptors in these samples that were expressed as percentage positivity...
May 18, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29782362/breast-conservation-therapy-after-neoadjuvant-chemotherapy-does-not-compromise-10-year-breast-cancer-specific-mortality
#10
Renee L Arlow, Lisa E Paddock, Xiaoling Niu, Laurie Kirstein, Bruce G Haffty, Sharad Goyal, Thomas Kearney, Deborah Toppmeyer, Antoinette M Stroup, Atif J Khan
OBJECTIVES: Neoadjuvant chemotherapy can increase the rate of breast-conserving surgery by downstaging disease in patients with breast cancer. The aim of this study was to determine whether patients who received neoadjuvant chemotherapy have equal survival after breast-conservation therapy compared with mastectomy. MATERIAL AND METHODS: Using the New Jersey State Cancer Registry (NJSCR) patients with a primary breast cancer diagnosed between 1998 and 2003 who underwent neoadjuvant chemotherapy were selected (n=1,468)...
May 18, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29782225/a-comparison-of-reproductive-and-energetic-states-in-a-marine-apex-predator-the-tiger-shark-galeocerdo-cuvier
#11
Neil Hammerschlag, Rachel A Skubel, James Sulikowski, Duncan J Irschick, Austin J Gallagher
To fuel the high energetic demands of reproduction, vertebrates employ different tactics of resource use. Large sharks exhibit long gestation periods and have relatively few well-developed young, which likely incurs high energetic costs. However, information on the relationship between the reproductive and energetic states for most shark species is lacking. In the present study, we used a noninvasive approach to assess relationships among reproductive stage, plasma triglyceride levels, body condition, and circulating reproductive hormones in free-ranging female tiger sharks (Galeocerdo cuvier)...
July 2018: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/29781760/solitary-fibrous-tumor-of-the-orbit-with-growth-during-pregnancy-a-case-report
#12
Robert A Hyde, Yunxiang Liu, Vinay K Aakalu, Pete Setabutr
We report the case of an anterior orbital tumor in a young woman that enlarged during pregnancy. The mass was excised and found to be a spindle cell tumor with immunohistochemical reactivity consistent with a solitary fibrous tumor, a rare entity in the spectrum of fibroblastic mesenchymal tumors. The tumor was strongly positive for the progesterone receptor, consistent with its clinical growth during the antenatal and postnatal periods. To our knowledge, a primary orbital tumor with these characteristics has rarely been reported in the literature...
May 21, 2018: Orbit
https://www.readbyqxmd.com/read/29781039/sex-dependent-association-of-circulating-sex-steroids-and-pituitary-hormones-with-treatment-free-survival-in-chronic-lymphocytic-leukemia-patients
#13
Eric P Allain, Karin Venzl, Patrick Caron, Véronique Turcotte, David Simonyan, Michaela Gruber, Trang Le, Eric Lévesque, Chantal Guillemette, Katrina Vanura
Chronic lymphocytic leukemia (CLL) is not considered a hormone-regulated cancer although sex is a recognized risk factor with men more frequently diagnosed and developing progressive disease. We hypothesized that variable hormonal exposure may have a sexually dimorphic influence on treatment-free survival (TFS). In 156 CLL cases, we quantitatively profiled 29 circulating steroids (progesterone, adrenal precursors, androgens, estrogens, and catechol estrogens) as well as luteinizing hormone (LH) and follicle-stimulating hormone...
May 21, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29780747/precision-medicine-in-hormone-receptor-positive-breast-cancer
#14
REVIEW
Azadeh Nasrazadani, Roby A Thomas, Steffi Oesterreich, Adrian V Lee
In recent decades, breast cancer has become largely manageable due to successes with hormone receptor targeting. Hormone receptor-positive tumors have favorable outcomes in comparison to estrogen receptor (ESR1, ER)/progesterone receptor-negative tumors given the targetable nature of these tumors, as well as their inherently less aggressive character. Nonetheless, treatment resistance is frequently encountered due to a variety of mechanisms, including ESR1 mutations and loss of ER expression. A new era of precision medicine utilizes a range of methodologies to allow real-time analysis of individual genomic signatures in metastases and liquid biopsies with the goal of finding clinically actionable targets...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29779488/bisphenol-a-induced-endocrinotoxicity-and-male-reprotoxicopathy-is-modulated-by-the-dietary-iron-deficiency
#15
Hina Rashid, Shikha Sharma, Saba Beigh, Firoz Ahmad, Sheikh Raisuddin
INTRODUCTION: Bisphenol A (BPA) is suspected to cause hormonal imbalance in humans. Dietary factors are known to bring changes in hormonal profile. In order to study chemico-biological interaction of iron deficiency on toxicity outcome of BPA exposure, we studied the modulatory effects of iron deficiency on the hormone levels in rats chronically-exposed to BPA. METHODS: Weanling rats maintained on normal and iron-deficient diets were exposed to low level of BPA at 0, 1, 5 and 10 ppm for six months through drinking water...
May 20, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29778464/peroxiredoxin-2-deficiency-accelerates-age-related-ovarian-failure-through-the-reactive-oxygen-species-mediated-jnk-pathway-in-mice
#16
Sun-Ji Park, Jung-Hak Kim, Dong Gil Lee, Jin-Man Kim, Dong-Seok Lee
Reactive oxygen species (ROS) produced in biological reactions have been shown to contribute to ovarian aging. Peroxiredoxin 2 (Prx2) is an antioxidant enzyme that protects cells by scavenging ROS; however, its effect on age-related, oxidative stress-associated ovarian failure has not been reported. Here, we investigated its role in age-related ovarian dysfunction and 4-vinylcyclohexene diepoxide (VCD)-induced premature ovarian failure using Prx2-deficient mice. Compared to those in wildtype (WT) mice, serum levels of anti-Müllerian hormone, 17β-estradiol, and progesterone and numbers of follicles and corpora lutea were significantly lower in 18-month-old Prx2-/- mice...
May 17, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29778461/average-ovarian-hormone-levels-rather-than-daily-values-and-their-fluctuations-are-related-to-facial-preferences-among-women
#17
Urszula M Marcinkowska, Gwenael Kaminski, Anthony C Little, Grazyna Jasienska
Hormones are of crucial importance for human behavior. Cyclical changes of ovarian hormones throughout women's menstrual cycle are suggested to underlie fluctuation in masculinity preference for both faces and bodies. In this study we tested this hypothesis based on daily measurements of estradiol and progesterone throughout menstrual cycle, and multiple measurements of women's preference towards masculinity of faces and bodies of men. We expected that due to a large variation among daily hormonal levels we would not observe a direct effect of daily hormone levels, but rather that average levels of ovarian hormones throughout the cycle (a reliable marker of a probability of conception) would better predict women's preferences...
May 17, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29778442/developmental-profiles-of-progesterone-receptor-transcripts-and-molecular-responses-to-gestagen-exposure-during-silurana-tropicalis-early-development
#18
Paisley Thomson, Valerie S Langlois
Environmental gestagens are an emerging class of contaminants that have been recently measured in surface water and can interfere with reproduction in aquatic vertebrates. Gestagens include endogenous progestogens, such as progesterone (P4), which bind P4-receptors and have critically important roles in vertebrate physiology and reproduction. Gestagens also include synthetic progestins, which are components of human and veterinary drugs, such as melengestrol acetate (MGA). Endogenous progestogens are essential in the regulation of reproduction in mammalian species, but the role of P4 in amphibian larval development remains unclear...
May 17, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29778368/oral-dydrogesterone-for-luteal-phase-support-in-fresh-in-vitro-fertilization-cycles-a-new-standard
#19
REVIEW
Georg Griesinger, Christophe Blockeel, Herman Tournaye
Oral dydrogesterone has been used for luteal phase support on an empirical basis since the early days of in vitro fertilization (IVF) treatment. Systematic comparisons of oral dydrogesterone with vaginal progesterone, so far considered to be the standard of care, started to appear in the middle 2000s. Recently, a large, randomized, double-blind, double-dummy phase III trial on the use of daily 30 mg oral dydrogesterone versus daily 600 mg micronized vaginal progesterone for LPS in IVF was published. This company-sponsored trial confirmed the efficacy findings from previous independent researchers and firmly established the noninferiority of daily 30 mg oral dydrogesterone for luteal phase support...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29778367/role-of-gonadotropin-releasing-hormone-agonists-human-chorionic-gonadotropin-hcg-progesterone-and-estrogen-in-luteal-phase-support-after-hcg-triggering-and-when-in-pregnancy-hormonal-support-can-be-stopped
#20
REVIEW
Dominique de Ziegler, Paul Pirtea, Claus Yding Andersen, Jean Marc Ayoubi
Luteal phase support is mandatory in ovarian stimulation cycles in assisted reproductive technology owing to a deficit in LH pulsatility after the effects of exogenous hCG-used for triggering ovulation-vanish. This is classically accomplished by means of exogenous P administration, but emerging new options include microdoses of hCG and exogenous GnRH agonist. Although luteal phase support is commonly continued for up to 10 weeks into pregnancy, there is accumulating evidence that it can be stopped after the first ultrasound or even after a positive pregnancy test...
May 2018: Fertility and Sterility
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