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https://www.readbyqxmd.com/read/28454423/the-nutritional-herb-epimedium-grandiflorum-inhibits-the-growth-in-a-model-for-the-luminal-a-molecular-subtype-of-breast-cancer
#1
Nitin T Telang, Gou Li, Meena Katdare, Daniel W Sepkovic, H Leon Bradlow, George Y C Wong
The Luminal A subtype of breast cancer expresses the estrogen receptor (ER)-α and progesterone receptor (PR), but not the human epidermal growth factor receptor (HER)-2 oncogene. This subtype of breast cancer responds to endocrine therapy involving the use of selective estrogen receptor modulators and/or inhibitors of estrogen biosynthesis. However, these therapeutic agents are frequently associated with long-term systemic toxicity and acquired tumor resistance, emphasizing the need to identify non-toxic alternative treatments for chemo-endocrine therapy responsive breast cancer...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454369/overexpression-of-erythropoietin-producing-hepatocyte-receptor-b4-and-ephrin-b2-is-associated-with-estrogen-receptor-expression-in-endometrial-adenocarcinoma
#2
Ling-Dan Dong, Xiang-Lin Cheng, Long Zhou, Qing Huang, Jun-Chuan Li, Cun-Jian Yi
Endometrial adenocarcinoma (EC) is one of the most frequently diagnosed types of endometrial cancer and is typically a consequence of continuous estrogen receptor stimulation. Erythropoietin-producing hepatocyte receptor B4 (EphB4) and its ligand ephrin-B2 have been reported to be overexpressed in EC cells; however, the function in EC remains unclear. The present study aimed to elucidate the role of EphB4 and ephrin-B2 in EC. The protein expression pattern of EphB4 and ephrin-B2 was analyzed through immunohistochemistry and western blot analysis in endometrium with adenomyosis or simple endometrial hyperplasia, atypical endometrial hyperplasia, double-positive estrogen receptor (ER)/progesterone receptor (PR) EC and double-negative ER/PR EC...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454055/evaluation-of-a-commercially-available-radioimmunoassay-and-enzyme-immunoassay-for-the-analysis-of-progesterone-and-estradiol-and-the-comparison-of-two-extraction-efficiency-methods
#3
C S Skenandore, A Pineda, J M Bahr, A E Newell-Fugate, F C Cardoso
The measurement of progesterone (P4) and estradiol (E2) is essential for monitoring reproductive cycles and can aid in diagnosing the cause of poor reproductive performance in dairy cattle. Readily available, reproducible, accurate, non-radioactive assays are needed for the assessment of P4 and E2 in bovine serum. The gold standard for hormone assessment, radioimmunoassay (RIA), was compared with enzyme-linked immunoassay (EIA). Serum collected from various points in the estrous cycle was extracted with radiolabeled P4 (ie, (3)H-P4; HE) and without (3)H-P4 (CE) before being used in the assay...
April 5, 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/28449068/development-of-a-novel-human-recellularized-endometrium-that-responds-to-a-28-day-hormone-treatment
#4
Susan A Olalekan, Joanna E Burdette, Spiro Getsios, Teresa K Woodruff, J Julie Kim
Three dimensional (3D) in vitro models have been established to study the physiology and pathophysiology of the endometrium. With emerging evidence that the native extracellular matrix (ECM) provides appropriate cues and growth factors essential for tissue homeostasis, we describe, a novel 3D endometrium in vitro model developed from decellularized human endometrial tissue repopulated with primary endometrial cells. Analysis of the decellularized endometrium using mass spectrometry analysis revealed an enrichment of cell adhesion molecules, cytoskeletal proteins and ECM proteins such as Collagen IV and Laminin...
April 25, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28448910/exposure-to-2-2-4-4-tetrabromodiphenyl-ether-at-late-gestation-modulates-placental-signaling-molecules-in-the-mouse-model
#5
Yun Zhu, Yan Qin Tan, Lai K Leung
Polybrominated diphenyl ethers (PBDEs) are flame retardants generally employed in manufacturing household items. Surface water may remove and carry these chemicals to the drainage upon disposal of the items, and ultimately the chemicals enter our food chain. 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) is a PBDE congener commonly found in contaminated seafood. The placenta is the site of nutrient exchange and is responsible for reproductive hormone secretion during pregnancy. In the present study, pregnant ICR mice were given p...
April 22, 2017: Chemosphere
https://www.readbyqxmd.com/read/28448746/pharmaceutical-chemicals-steroids-and-xenoestrogens-in-water-sediments-and-fish-from-the-tidal-freshwater-potomac-river-virginia-usa
#6
Golala Arya, Sara Tadayon, James Sadighian, Jennifer Jones, Kim de Mutsert, Thomas B Huff, Gregory D Foster
Selected pharmaceutical chemicals, steroids and xenoestrogens (PCSXs) consisting of 29 endocrine modulators, therapeutic drugs, pesticides, detergents, plastics, and active ingredients in household products were measured in water, riverbed sediments and fish collected in a tributary embayment of the Potomac River (Hunting Creek, Alexandria, VA, USA) in the vicinity of wastewater discharge. A total of 17 PCSXs were found in the Hunting Creek samples, with steroid hormones (e.g., progesterone and 17α-ethinylestradiol), triclosan, dextromethorphan and bisphenol A being the most prominent micropollutants detected...
April 27, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/28447735/mice-endometrium-receptivity-in-early-pregnancy-is-impaired-by-maternal-hyperinsulinemia
#7
Runqin Li, Juan Wu, Junlin He, Yingxiong Wang, Xueqing Liu, Xuemei Chen, Chao Tong, Yubin Ding, Yan Su, Wenqi Chen, Chen Zhang, Rufei Gao
Previous studies have investigated the lower embryo implantation rates in women with polycystic ovary syndrome, obesity and type 2 diabetes, and specifically the association between the abnormal oocyte and embryo and hyperinsulinemia. The importance of hyperinsulinemia on maternal endometrium receptivity remains to be elucidated. The present study used a hyperinsulinemic mouse model to determine whether hyperinsulinemia may affect endometrial receptivity. An insulin intervention mouse model was first established...
March 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28447709/-atypical-cushing-s-syndrome-in-a-dog-a-case-report
#8
Stefanie Hoffrogge, Lena Fels, Marion Schmicke, Reinhard Mischke
In a 12-year-old male Labrador Retriever, presented due to other disease symptoms, clinical signs of hyperadrenocorticism (polyuria, polydipsia, abdominal distention, muscle atrophy) were an incidental finding. Abnormal laboratory results and sonographic findings of the adrenal glands, but negative low-dose dexamethasone suppression tests with low basal cortisol concentrations, a negative andrenocorticotropic hormone (ACTH)-stimulation test and exclusion of iatrogenic hyperadrenocorticism, suggested an atypical hyperadrenocorticism (AHAC)...
April 27, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28447505/does-pituitary-suppression-affect-live-birth-rate-in-women-with-congenital-hypogonadotrophic-hypogonadism-undergoing-intra-cytoplasmic-sperm-injection-a-multicenter-cohort-study
#9
Sezcan Mumusoglu, Baris Ata, Volkan Turan, Berfu Demir, Inci Kahyaoglu, Kiper Aslan, Ayse Seyhan Ata, Bulent Yilmaz, Kayhan Yakin, Berrin Avci, Gurkan Uncu, Gurkan Bozdag
In this retrospective multicenter cohort study, women with congenital hypogonadotrophic hypogonadism (CHH) (n = 57) who underwent intra-cytoplasmic sperm injection in-between 2010-2014 were compared to age-matched controls with tubal factor infertility (n = 114) to assess ovarian stimulation cycle and pregnancy outcomes. Live birth rates (LBRs) per started cycle were 31.6 and 24.6% in CHH and controls groups, respectively (p = 0.36). Comparable success rates were also confirmed with the logistic regression analysis (OR: 1...
April 27, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28447367/sex-hormones-function-as-sex-attractant-pheromones-in-house-mice-and-brown-rats
#10
Stephen Takacs, Regine Gries, Gerhard J Gries
Sex hormones of mammals control the expression of sexual characteristics and bodily functions. The male hormone testosterone and the female hormones progesterone and estradiol are known to occur in urine markings of mice. Herein, we show that all three hormones are also present in urine of brown rats, and that they are effective sexual communication signals (pheromones) that elicit attraction behavior of prospective mates in both brown rats and house mice. When added as lures to trap boxes in field experiments, synthetic testosterone, e...
April 26, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28447121/persistent-organic-pollutant-and-hormone-levels-in-harbor-porpoise-with-b-cell-lymphoma
#11
Stephanie A Norman, Zach C Winfield, Barry H Rickman, Sascha Usenko, Matthew Klope, Susan Berta, Sandra Dubpernell, Howard Garrett, Mary Jo Adams, Dyanna Lambourn, Jessica L Huggins, Nadine Lysiak, Adelaide E Clark, Rebel Sanders, Stephen J Trumble
B-cell lymphoma, a common morphologic variant of non-Hodgkin lymphoma, has been associated with persistent pollutants in humans, but this association is not well-characterized in top-level predators sharing marine resources with humans. We characterized and compared blubber contaminants and hormones of a pregnant harbor porpoise (Phocoena phocoena) with B-cell lymphoma, with those in two presumed healthy fishery by-caught porpoises with no lymphoma: a pregnant adult and female juvenile. Common historic use compounds, including polychlorinated biphenyls, polybrominated diphenyl ethers, and pesticides, were evaluated in blubber samples from three porpoises...
April 26, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28446940/a-case-of-disseminated-peritoneal-leiomyomatosis-after-two-laparoscopic-procedures-due-to-uterine-fibroids
#12
Michał Ciebiera, Aneta Słabuszewska-Jóźwiak, Kornelia Zaręba, Grzegorz Jakiel
Disseminated peritoneal leiomyomatosis (DPL) is a rare disorder characterized by the presence of multifocal nodules and tumors composed of proliferating smooth muscle tissue, spread throughout the peritoneum. Estrogens and progesterone are considered to be the main factors initiating the formation of disseminated leiomyomatosis. Disseminated peritoneal leiomyomatosis is often asymptomatic, and acyclic vaginal bleeding or pain in the lower abdomen is associated with leiomyomatous rebuilt uterus corpus. Disseminated peritoneal leiomyomatosis can have other ambiguous presentation...
2017: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/28444869/assessment-of-the-usage-of-biodegradable-polymeric-matrix-in-vaginal-devices-to-sustain-progesterone-release-in-cows
#13
José Rodrigo Valim Pimentel, Milton Maturana Filho, Lucio Cardozo-Filho, José Augusto M Agnelli, Jefter Nascimento, Ed Hoffmann Madureira
The usage of timed artificial insemination (TAI) at a low cost leading to better reproductive rates has been the aim of several research groups in the field. Usually during TAI protocols, sustained progesterone (P4 ) release devices are employed. Most devices are constituted of a nylon skeleton covered with a silicon layer with P4 . A device based on biopolymers was developed in order to reduce costs and decrease its environmental impact. In this study, we compared the kinetics of sustained progesterone release among devices manufactured with a polymeric blend made of polyhydroxybutyrate-valerate (PHBV) and poly-ε-caprolactone (PCL) (DISP) which were compared with DIB® (Internal Bovine Device) used as the control...
April 25, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28444736/selective-progesterone-receptor-modulators-sprms-for-uterine-fibroids
#14
REVIEW
Ally Murji, Lucy Whitaker, Tiffany L Chow, Mara L Sobel
BACKGROUND: Uterine fibroids are smooth muscle tumours arising from the uterus. These tumours, although benign, are commonly associated with abnormal uterine bleeding, bulk symptoms and reproductive dysfunction. The importance of progesterone in fibroid pathogenesis supports selective progesterone receptor modulators (SPRMs) as effective treatment. Both biochemical and clinical evidence suggests that SPRMs may reduce fibroid growth and ameliorate symptoms. SPRMs can cause unique histological changes to the endometrium that are not related to cancer, are not precancerous and have been found to be benign and reversible...
April 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28443693/confounder-factors-masking-a-leydig-cell-ovarian-tumor-in-a-post-menopausal-woman-treated-for-androgen-positive-receptor-breast-cancer
#15
Felipe Scipião Moura, Flávia A Costa-Barbosa, Sydney Correia Leao, Sergio Mancini Nicolau, Claudio E Kater, Patrícia T Monteagudo
Post-menopause hyperandrogenism is a condition that needs careful evaluation. Aromatase inhibitors (AI), which are important in the management of positive estrogen breast cancer, and chronic kidney disease (CKD) can puzzle the evaluation of this condition. A postmenopause female with type-2 diabetes and advanced CKD was attended due to progressive virilization, which has started after the introduction of an AI for breast cancer 5 years earlier. Clinical and radiological investigation has confirmed a pure Leydig cell tumor as source of hyperandrogenism...
April 26, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28443690/vitrified-warmed-blastocyst-transfer-on-the-5th-or-7th-day-of-progesterone-supplementation-in-an-artificial-cycle-a-randomised-controlled-trial
#16
A van de Vijver, P Drakopoulos, N P Polyzos, L Van Landuyt, S Mackens, S Santos-Ribeiro, V Vloeberghs, H Tournaye, C Blockeel
Prospective studies comparing different durations of progesterone supplementation before transfer of vitrified-warmed blastocysts in an artificial cycle are lacking. However, in oocyte donation programmes, the sporadic available evidence demonstrates considerable differences in clinical pregnancy rates according to the duration of progesterone administration. This randomised controlled trial (RCT), included 303 patients undergoing a frozen-thawed embryo transfer (FET) of one or two vitrified-warmed blastocyst(s) in an artificial cycle...
April 26, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28443466/promoter-methylation-and-gene-polymorphism-are-two-independent-events-in-regulation-of-gstp1-gene-expression
#17
Aaliya Bhat, A Masood, K A Wani, Younus Ahmad Bhat, Bushra Nissar, Nuzhat Shaheen Khan, B A Ganai
Breast carcinogenesis is a multistep process, involving both genetic and epigenetic modification process of genes, involved in diverse pathways ranging from DNA repair to metabolic processes. This study was undertaken to assess the role of promoter methylation of GSTP1 gene, a member of glutathione-S-transferase family of enzymes, in relation to its expression, polymorphism, and clinicopathological parameters. Tissue samples were taken from breast cancer patients and paired with their normal adjacent tissues...
April 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28443299/data-on-the-mrna-expression-by-in-situ-hybridization-of-wnt-signaling-pathway-members-in-the-mouse-uterus
#18
Jyoti Goad, Yi-An Ko, Shafiq M Syed, Yazmin J Crossingham, Pradeep S Tanwar
Wnt signaling plays an important role in uterine organogenesis and oncogenesis. Our mRNA expression data documents the expression of various Wnt pathway members during the key stages of uterine epithelial gland development. Our data illustrates the expression of Wnt signaling inhibitors (Axin2, Sfrp2, Sfrp4, Dkk1 and Dkk3) in mice uteri at postnatal day 6 (PND 6) and day 15 (PND 15). They also describe the expression pattern of the Wnt ligands (Wnt1, Wnt2, Wnt2b, Wnt3, Wnt3a, Wnt5b, Wnt7b, Wnt8a, Wnt8b, Wnt9a, Wnt9b, Wnt10a and Wnt10b) in mice uteri with or without progesterone treatment...
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28443261/diabetes-mellitus-caused-by-secondary-hemochromatosis-after-multiple-blood-transfusions-in-2-patients-with-severe-aplastic-anemia
#19
Hyun Jin Kim, Yoon-Myung Kim, Eungu Kang, Beom Hee Lee, Jin-Ho Choi, Han-Wook Yoo
Hemochromatosis is an inherited or secondary disorder caused by excessive iron storage leading to multiple organ damage. We describe 2 patients with diabetes mellitus caused by hemochromatosis secondary to multiple blood transfusions due to severe aplastic anemia. Subject 1, who was diagnosed with severe aplastic anemia at 15 years of age, received multiple red blood cell transfusions before he underwent autologous peripheral blood stem cell transplantation (PBSCT) at 22 years of age. At 21 years of age, hyperglycemia was detected with increased hemoglobin A1c and serum ferritin levels, 9...
March 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28442641/regulation-of-uridine-diphosphate-glucuronosyltransferase-2b15-expression-during-ovulation-in-the-rat
#20
Phuong T M Dam, You-Jee Jang, Jae-Il Park, Bum-Chae Choi, Sang-Jin Song, Sang-Young Chun
Uridine diphosphate-glucuronosyltransferase 2B15 (UGT2B15) conjugates 5α-androstane-3α, 17β-diol (3α-diol) to 3α-diol glucuronide (3α-diol G) in steroid target tissues. The present study investigated the regulation of UGT2B15 expression during the ovulatory process in the rat. Real-time PCR analysis revealed that treatment of immature rats with equine chorionic gonadotropin followed by human chorionic gonadotropin transiently stimulated UGT2B15 gene expression in granulosa cells of preovulatory follicles within 6 h...
April 22, 2017: Endocrine Journal
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