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https://www.readbyqxmd.com/read/28226417/an-efficient-multi-stage-algorithm-for-full-calibration-of-the-hemodynamic-model-from-bold-signal-responses
#1
Brian Zambri, Rabia Djellouli, Meriem Laleg-Kirati
We propose a computational strategy that falls into the category of prediction/correction iterative-type approaches, for calibrating the hemodynamic model introduced by Friston et al. (2000). The proposed method is employed to estimate consecutively the values of the biophysiological system parameters and the external stimulus characteristics of the model. Numerical results corresponding to both synthetic and real functional Magnetic Resonance Imaging (fMRI) measurements for a single stimulus as well as for multiple stimuli are reported to highlight the capability of this computational methodology to fully calibrate the considered hemodynamic model...
February 22, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28220977/evaluation-of-di-potassium-and-tri-potassium-edta-evacuated-tubes-for-routine-haematological-testing
#2
Rubaida Mehmood, Rabia Khushi Muhammed, Sajjid Hussain, Aniqa Sana
BACKGROUND: The influence of blood collection devices on laboratory tests is often overlooked. We have discussed here how blood collection materials and devices can alter haematological test results, with an emphasis on blood collection tube (BCT) additives. We have compared K2 & K3-EDTA vacuum tubes of same manufacturer IMPROVACUTER (®) for CBC analysis. METHODS: Blood was collected in both tubes simultaneously. Samples were analysed immediately after collection (<15 minutes) and after 4 hours by MEK-6318J/K Haematology Analyzer...
February 21, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28185443/neutrophil-lymphocyte-ratio-better-addition-to-crp-than-cd64-index-as-marker-for-infection-in-copd
#3
Raymond Farah, Rabia Ibrahim, Majd Nassar, Dally Najib, Yifat Zivony, Elizabeth Eshel
OBJECTIVE: This study investigated the importance of neutrophil-lymphocyte ratio (NLR) and other new inflammatory markers including CD64 expression in patients with chronic obstructive pulmonary disease (COPD) for identifying the severity of inflammation and recognition of acute exacerbation and infection. METHODS: 72 patients with a diagnosis of COPD exacerbation who were admitted to Internal Medicine B department, 13 stable COPD, and control group of 15 healthy persons were enrolled in the study...
February 9, 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28168318/endophyte-bioprospecting-in-south-asian-medicinal-plants-an-attractive-resource-for-biopharmaceuticals
#4
REVIEW
Rabia Tanvir, Aqeel Javeed, Aamir Ghafoor Bajwa
From the last several years, there has been an increasing interest in plant-associated bacteria commonly referred to as endophytes that reside asymptomatically in the internal plant tissues. This interest peaked since the last two decades due to the recognition that endophytes within medicinal plants have the capability to mimic and produce the bioactive metabolites of the host plant. A number of medicinal plants have been used for centuries by the people of South Asia to cure various diseases and this has led to abundant usage experience...
February 6, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28151489/molecular-diagnosis-of-pik3ca-related-overgrowth-spectrum-pros-in-162-patients-and-recommendations-for-genetic-testing
#5
Paul Kuentz, Judith St-Onge, Yannis Duffourd, Jean-Benoît Courcet, Virginie Carmignac, Thibaud Jouan, Arthur Sorlin, Claire Abasq-Thomas, Juliette Albuisson, Jeanne Amiel, Daniel Amram, Stéphanie Arpin, Tania Attie-Bitach, Nadia Bahi-Buisson, Sébastien Barbarot, Geneviève Baujat, Didier Bessis, Olivia Boccara, Maryse Bonnière, Odile Boute, Anne-Claire Bursztejn, Christine Chiaverini, Valérie Cormier-Daire, Christine Coubes, Bruno Delobel, Patrick Edery, Salima El Chehadeh, Christine Francannet, David Geneviève, Alice Goldenberg, Damien Haye, Bertrand Isidor, Marie-Line Jacquemont, Philippe Khau Van Kien, Didier Lacombe, Ludovic Martin, Jelena Martinovic, Annabel Maruani, Michèle Mathieu-Dramard, Juliette Mazereeuw-Hautier, Caroline Michot, Cyril Mignot, Juliette Miquel, Fanny Morice-Picard, Florence Petit, Alice Phan, Massimiliano Rossi, Renaud Touraine, Alain Verloes, Marie Vincent, Catherine Vincent-Delorme, Sandra Whalen, Marjolaine Willems, Nathalie Marle, Daphné Lehalle, Julien Thevenon, Christel Thauvin-Robinet, Smaïl Hadj-Rabia, Laurence Faivre, Pierre Vabres, Jean-Baptiste Rivière
PURPOSE: Postzygotic activating mutations of PIK3CA cause a wide range of mosaic disorders collectively referred to as PIK3CA-related overgrowth spectrum (PROS). We describe the diagnostic yield and characteristics of PIK3CA sequencing in PROS. METHODS: We performed ultradeep next-generation sequencing (NGS) of PIK3CA in various tissues from 162 patients referred to our clinical laboratory and assessed diagnostic yield by phenotype and tissue tested. RESULTS: We identified disease-causing mutations in 66...
February 2, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28146135/the-transcription-profile-unveils-the-cardioprotective-effect-of-aspalathin-against-lipid-toxicity-in-an-in-vitro-h9c2-model
#6
Rabia Johnson, Phiwayinkosi V Dludla, Christo J F Muller, Barbara Huisamen, M Faadiel Essop, Johan Louw
Aspalathin, a C-glucosyl dihydrochalcone, has previously been shown to protect cardiomyocytes against hyperglycemia-induced shifts in substrate preference and subsequent apoptosis. However, the precise gene regulatory network remains to be elucidated. To unravel the mechanism and provide insight into this supposition, the direct effect of aspalathin in an isolated cell-based system, without the influence of any variables, was tested using an H9c2 cardiomyocyte model. Cardiomyocytes were exposed to high glucose (33 mM) for 48 h before post-treatment with or without aspalathin...
January 31, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28134327/il-32-promoter-snp-rs4786370-predisposes-to-modified-lipoprotein-profiles-in-patients-with-rheumatoid-arthritis
#7
Michelle S M A Damen, Rabia Agca, Suzanne Holewijn, Jacqueline de Graaf, Jéssica C Dos Santos, Piet L van Riel, Jaap Fransen, Marieke J H Coenen, Mike T Nurmohamed, Mihai G Netea, Charles A Dinarello, Leo A B Joosten, Bas Heinhuis, Calin D Popa
Patients with rheumatoid arthritis (RA) are at higher risk of developing cardiovascular diseases (CVD). Interleukin (IL)-32 has previously been shown to be involved in the pathogenesis of RA and might be linked to the development of atherosclerosis. However, the exact mechanism linking IL-32 to CVD still needs to be elucidated. The influence of a functional genetic variant of IL-32 on lipid profiles and CVD risk was therefore studied in whole blood from individuals from the NBS cohort and RA patients from 2 independent cohorts...
January 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28127171/knowledge-attitude-and-practices-of-dental-surgeons-in-managing-child-patients
#8
Aisha Wali, Talha Mufeed Siddiqui, Rabia Khan, Kanza Batool
: The aim of the study was to evaluate the knowledge, attitude, and practices of dental surgeons in the city of Karachi providing treatment to pediatric patients. A cross-sectional study was conducted to evaluate the knowledge, attitude, and practices of dental surgeons in the city of Karachi providing treatment to pediatric patients. A cluster-sampling technique was used and 200 dental surgeons from six different dental institutions were selected. A self-constructed questionnaire was distributed to the dental surgeons that comprised 20 closed-ended questions...
October 2016: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28125856/effect-of-topical-cyclopentolate-on-post-operative-pain-after-pterygium-surgery
#9
Sertan Goktas, Yasar Sakarya, Muammer Ozcimen, Rabia Sakarya, Ismail Alpfidan, Ismail Senol Ivacık, Erkan Erdogan
OBJECTIVES: The aim was to evaluate the effectiveness of topical cyclopentolate following pterygium surgery for post-operative ocular pain. METHODS: All participants had nasal pterygium and underwent pterygium excision and conjunctival autografting with fibrin glue. Participants were randomised into two groups. Participants in group 1 received one per cent cyclopentolate eye drops and artificial tears upon completing surgery and were prescribed self-administered drops three times daily for three days, while participants in group 2 received a control (artificial tears) in a manner identical to group 1...
January 26, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28118211/perioperative-surface-ultrasound-for-placement-and-confirmation-of-central-venous-access-a-case-report
#10
Jeffrey Bortman, Ziyad Knio, Rabia Amir, Khadija Hamid, Feroze Mahmood, Robina Matyal
We present a case highlighting that the real-time visualization of the guidewire in the internal jugular vein with ultrasound, and confirmation of correct position of the guidewire tip at the superior vena cava to right atrial junction with surface ultrasound, is possibly the safest method of central venous catheter insertion.
January 23, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28105635/dental-and-extra-oral-clinical-features-in-41-patients-with-wnt10a-gene-mutations-a-multicentric-genotype-phenotype-study
#11
C Tardieu, S Jung, K Niederreither, M Prasad, S Hadj-Rabia, N Philip, A Mallet, E Consolino, E Sfeir, B Noueiri, N Chassaing, H Dollfus, M-C Manière, A Bloch-Zupan, F Clauss
WNT10A gene encodes a canonical wingless pathway signaling molecule involved in cell fate specification as well as morphogenetic patterning of the developing ectoderm, nervous system, skeleton, and tooth. In patients, WNT10A mutations are responsible for ectodermal-derived pathologies including isolated hypo-oligodontia, tricho-odonto-onycho-dermal dysplasia (TOODD) and Schöpf-Schulz-Passarge Syndrome (SSPS). Here we describe the dental, ectodermal, and extra-ectodermal phenotypic features of a cohort of 41 patients from 32 unrelated families...
January 20, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28098811/aspalathin-protects-the-heart-against-hyperglycemia-induced-oxidative-damage-by-up-regulating-nrf2-expression
#12
Phiwayinkosi V Dludla, Christo J F Muller, Elizabeth Joubert, Johan Louw, M Faadiel Essop, Kwazi B Gabuza, Samira Ghoor, Barbara Huisamen, Rabia Johnson
Aspalathin (ASP) can protect H9c2 cardiomyocytes against high glucose (HG)-induced shifts in myocardial substrate preference, oxidative stress, and apoptosis. The protective mechanism of ASP remains unknown. However, as one of possible, it is well known that phytochemical flavonoids reduce oxidative stress via nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activation resulting in up-regulation of antioxidant genes and enzymes. Therefore, we hypothesized that ASP protects the myocardium against HG- and hyperglycemia-induced oxidative damage by up-regulating Nrf2 expression in H9c2 cardiomyocytes and diabetic (db/db) mice, respectively...
January 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28077214/intervention-effectiveness-of-the-incredible-years-new-insights-into-sociodemographic-and-intervention-based-moderators
#13
Joyce Weeland, Rabia R Chhangur, Danielle van der Giessen, Walter Matthys, Bram Orobio de Castro, Geertjan Overbeek
We tested the effectiveness of the preventive behavioral parent training (BPT) program, The Incredible Years (IY), and the independent effects of previously suggested sociodemographic and intervention-based moderator variables (i.e., initial severity of externalizing problem behavior, child gender, social economic status, family composition, and number of sessions parents attended), in a large-scale randomized controlled trial. Questionnaire and observation data from 387 parents and children ages 4-8 years (Mage= 6...
January 2017: Behavior Therapy
https://www.readbyqxmd.com/read/28074521/assessment-of-the-effectiveness-of-topical-propranolol-4-gel-for-infantile-hemangiomas
#14
Jacob Mashiah, Ana Kutz, Smail Hadj Rabia, Efrat Bar Ilan, Ilan Goldberg, Eli Sprecher, Avikam Harel
BACKGROUND: Infantile hemangiomas (IHs) are the most common vascular tumors in children. Because of their benign character and natural involution, the vast majority of IHs do not require any treatment. In the past few years, topical beta blockers have been reported to be an effective treatment of superficial IHs. OBJECTIVE: We sought to evaluate the clinical effectiveness and safety profile of topical propranolol 4% gel for the treatment of IHs. METHODS: A retrospective study of all cases of IHs treated with topical propranolol 4% gel between 2013 and 2015 was performed...
February 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28073484/the-genetics-biosynthesis-and-regulation-of-toxic-specialized-metabolites-of-cyanobacteria
#15
REVIEW
Leanne A Pearson, Elke Dittmann, Rabia Mazmouz, Sarah E Ongley, Paul M D'Agostino, Brett A Neilan
The production of toxic metabolites by cyanobacterial blooms represents a significant threat to the health of humans and ecosystems worldwide. Here we summarize the current state of the knowledge regarding the genetics, biosynthesis and regulation of well-characterized cyanotoxins, including the microcystins, nodularin, cylindrospermopsin, saxitoxins and anatoxins, as well as the lesser-known marine toxins (e.g. lyngbyatoxin, aplysiatoxin, jamaicamides, barbamide, curacin, hectochlorin and apratoxins).
April 2016: Harmful Algae
https://www.readbyqxmd.com/read/28063765/skin-autofluorescence-renal-insufficiency-and-retinopathy-in-patients-with-type-2-diabetes
#16
Rabia Bentata, Audrey Cougnard-Grégoire, Marie Noëlle Delyfer, Cécile Delcourt, Laurence Blanco, Emilie Pupier, Marie Bénédicte Rougier, Kalina Rajaobelina, Marie Hugo, Jean François Korobelnik, Vincent Rigalleau
OBJECTIVES: Advanced glycation end-products (AGEs) are involved in diabetic retinopathy (DR). Their accumulation in tissues can be analyzed by measuring the skin autofluorescence (sAF). We hypothesized that renal insufficiency, another cause of high sAF, may disturb the relation between sAF and DR. RESEARCH DESIGN AND METHODS: We measured sAF with an AGE-Reader in 444 patients with type 2 diabetes (T2D), and we analyzed their retinal status. The associations of sAF with DR, and interaction with renal insufficiency were estimated by multivariate logistic regression analysis...
October 30, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28033103/the-sublethal-effects-of-2-4-dichlorophenoxy-acetic-acid-2-4-d-on-narrow-clawed-crayfish-astacus-leptodactylus-eschscholtz-1823
#17
A Çağlan Karasu Benli, Duygu Şahin, Rabia Sarıkaya, Burcu Koçak Memmi, Aylin Sepici Dinçel
2,4-D is a widely used phenoxy herbicide, potentially toxic to humans and biota. The objective of the present study was to reveal short term sublethal effects of 2,4-D on narrow-clawed freshwater crayfish (Astacus leptodactylus Eschscholtz, 1823), based on histology, total haemocyte counts, selected haemolymph parameters, and oxidative stress parameters. In the laboratory conditions crayfish specimens were exposed to 9 mg L-1 of 2,4-D for one week. Experiments were conducted under semi-static conditions in 20 L-capacity aquaria where 10 freshwater crayfish were stocked per aquarium...
December 1, 2016: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/28025013/eosinophilic-esophagitis-and-colonic-mucosal-eosinophilia-in-netherton-syndrome
#18
Colombe Paluel-Marmont, Nathalia Bellon, Patrick Barbet, Stéphanie Leclerc-Mercier, Smail Hadj-Rabia, Christophe Dupont, Christine Bodemer
No abstract text is available yet for this article.
December 23, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28018696/alagille-syndrome-a-case-report-highlighting-dysmorphic-facies-chronic-illness-and-depression
#19
James J Bresnahan, Zachary A Winthrop, Rabia Salman, Salman Majeed
Alagille syndrome is a rare multisystem disorder affecting the liver, heart, vertebrae, eyes, and face. Alagille syndrome shares multiple phenotypic variants of other congenital or chronic childhood illnesses such as DiGeorge syndrome, Down syndrome, spina bifida, type 1 diabetes mellitus, and cystic fibrosis. All of these chronic illnesses have well-established links to psychiatric conditions. There are few community resources for Alagille patients, as it is an extremely rare condition. Despite the overlap with other chronic childhood illnesses, the psychiatric manifestations of Alagille syndrome have not been previously discussed in literature...
2016: Case Reports in Psychiatry
https://www.readbyqxmd.com/read/28018088/fracture-of-the-scapholunate-coalition
#20
Önder Yeniçeri, Nesat Cullu, Halil Beydilli, Mehmet Deveer, Rabia Mihriban Kilinc
No abstract text is available yet for this article.
October 2016: Journal of Clinical Orthopaedics and Trauma
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