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Exercise induced muscle damage

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https://www.readbyqxmd.com/read/27913923/actn3-x-allele-carriers-had-greater-levels-of-muscle-damage-during-a-half-ironman
#1
Juan Del Coso, Juan José Salinero, Beatriz Lara, César Gallo-Salazar, Francisco Areces, Carlos Puente, David Herrero
PURPOSE: Alpha-actinin-3, encoded by the ACTN3 gene, is an actin-binding protein with an important role in myofibril contraction and muscle force output. In humans, there is a relatively common deficiency of the α-actinin-3 due to homozygosity in a polymorphism of the ACTN3 gene (R577X, rs1815739), that has been related to decreased resistance to strain during voluntary muscle contractions. The purpose of this study was to investigate the influence of the ACTN3 genotype on the level of exercise-induced muscle damage attained by 23 experienced triathletes during an official half-ironman competition...
December 2, 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/27912940/panax-ginseng-and-salvia-miltiorrhiza-supplementation-during-eccentric-resistance-training-in-middle-aged-and-older-adults-a-double-blind-randomized-control-trial
#2
Hsin-Fu Lin, Chun-Chung Chou, Hsiao-Han Chao, Hirofumi Tanaka
BACKGROUND: Muscle damage induced by an acute bout of eccentric exercise results in transient arterial stiffening. In this study, we sought to determine the effects of progressive eccentric resistance exercise training on vascular functions, and whether herb supplementation would enhance training adaptation by ameliorating the arterial stiffening effects. METHODS: By using a double-blinded randomized placebo-controlled design, older adults were randomly assigned to either the Panax ginseng and Salvia miltiorrhiza supplementation group (N=12) or the placebo group (N=11)...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27911915/marathon-race-affects-neutrophil-surface-molecules-role-of-inflammatory-mediators
#3
Vinicius Coneglian Santos, Ana Paula Renno Sierra, Rodrigo Oliveira, Kim Guimarães Caçula, César Miguel Momesso, Fabio Takeo Sato, Maysa Braga Barros Silva, Heloisa Helena Oliveira, Maria Elizabeth Pereira Passos, Diego Ribeiro de Souza, Olivia Santos Gondim, Marino Benetti, Adriana Cristina Levada-Pires, Nabil Ghorayeb, Maria Augusta Peduti Dal Molin Kiss, Renata Gorjão, Tânia Cristina Pithon-Curi, Maria Fernanda Cury-Boaventura
The fatigue induced by marathon races was observed in terms of inflammatory and immunological outcomes. Neutrophil survival and activation are essential for inflammation resolution and contributes directly to the pathogenesis of many infectious and inflammatory conditions. The aim of this study was to investigate the effect of marathon races on surface molecules related to neutrophil adhesion and extrinsic apoptosis pathway and its association with inflammatory markers. We evaluated 23 trained male runners at the São Paulo International Marathon 2013...
2016: PloS One
https://www.readbyqxmd.com/read/27909227/castration-alters-protein-balance-following-high-frequency-muscle-contraction
#4
Jennifer L Steiner, David H Fukuda, Michael L Rossetti, Jay R Hoffman, Bradley S Gordon
Resistance exercise increases muscle mass by shifting protein balance in favor of protein accretion. Androgens independently alter protein balance, but it is unknown whether androgens alter this measure following resistance exercise. To answer this, male mice were subjected to sham or castration surgery 7-8 weeks prior to undergoing a bout of unilateral, high frequency, electrically induced muscle contractions in the fasted or refed state. Puromycin was injected 30 min prior to sacrifice to measure protein synthesis...
December 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27903048/resistance-exercise-induced-rhabdomyolysis-need-for-immediate-intervention-and-proper-counselling
#5
Maysaa A Khalil, Basem R Saab
BACKGROUND: Rhabdomyolysis results from damage to skeletal muscle. Improper resistance training may result in rhabdomyolysis, which can cause acute kidney injury, serious metabolic abnormalities, compartmental syndrome and even death. Proper counselling for athletes may prevent this condition. OBJECTIVE: We present two patients with unilateral swelling after resistance exercise. The workup revealed rhabdomyolysis. We highlight the importance of counselling to prevent rhabdomyolysis secondary to resistance exercise...
December 2016: Australian Family Physician
https://www.readbyqxmd.com/read/27899787/mcardle-disease-misdiagnosed-as-meningitis
#6
Renata Siciliani Scalco, Sherryl Chatfield, Muhammad Hyder Junejo, Suzanne Booth, Jatin Pattni, Richard Godfrey, Ros Quinlivan
BACKGROUND McArdle disease is a glycogen storage disorder mainly characterized by exercise intolerance. Prolonged muscle contracture is also a feature of this condition and may lead to rhabdomyolysis (RM), which is a serious event characterized by acute skeletal muscle damage.  CASE REPORT A 44-year-old female patient presented with an acute contracture of the posterior neck muscles, causing severe nuchal rigidity. The contracture was induced during a dental extraction as she held her mouth open for a prolonged period, with her neck in a rigid position...
November 30, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27893481/the-effect-of-exercise-induced-muscle-damage-after-a-bout-of-accentuated-eccentric-load-drop-jumps-and-the-repeated-bout-effect
#7
Lee A Bridgeman, Nicholas D Gill, Deborah K Dulson, Michael R McGuigan
Although previous studies have investigated exercise induced muscle damage (EIMD) after a bout of unloaded drop jumps (DJ) none have investigated the effects of accentuated eccentric load (AEL) DJs on EIMD. The purpose of this study was to investigate the effects of 30 and 50 AEL DJs on strength, jump performance, muscle soreness and blood markers. Eight resistance trained athletes participated in this study. In week 1 baseline countermovement jump (CMJ), squat jump (SJ), concentric and eccentric peak force (PF), creatine kinase (CK) and muscle soreness (SOR) were assessed...
November 16, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27884955/effect-of-exercise-induced-muscle-damage-on-vascular-function-and-skeletal-muscle-microvascular-deoxygenation
#8
Jacob T Caldwell, Garrett C Wardlow, Patrece A Branch, Macarena Ramos, Christopher D Black, Carl J Ade
This paper investigated the effects of unaccustomed eccentric exercise-induced muscle damage (EIMD) on macro- and microvascular function. We tested the hypotheses that resting local and systemic endothelial-dependent flow-mediated dilation (FMD) and microvascular reactivity would decrease, V˙O2max would be altered, and that during ramp exercise, peripheral O2 extraction, evaluated via near-infrared-derived spectroscopy (NIRS) derived deoxygenated hemoglobin + myoglobin ([HHb]), would be distorted following EIMD In 13 participants, measurements were performed prior to (Pre) and 48 h after a bout of knee extensor eccentric exercise designed to elicit localized muscle damage (Post)...
November 2016: Physiological Reports
https://www.readbyqxmd.com/read/27872595/redox-mechanism-of-reactive-oxygen-species-in-exercise
#9
REVIEW
Feng He, Juan Li, Zewen Liu, Chia-Chen Chuang, Wenge Yang, Li Zuo
It is well known that regular exercise can benefit health by enhancing antioxidant defenses in the body. However, unaccustomed and/or exhaustive exercise can generate excessive reactive oxygen species (ROS), leading to oxidative stress-related tissue damages and impaired muscle contractility. ROS are produced in both aerobic and anaerobic exercise. Mitochondria, NADPH oxidases and xanthine oxidases have all been identified as potential contributors to ROS production, yet the exact redox mechanisms underlying exercise-induced oxidative stress remain elusive...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27836414/identification-of-the-igf-1-processing-product-human-ec-rodent-eb-peptide-in-various-tissues-evidence-for-its-differential-regulation-after-exercise-induced-muscle-damage-in-humans
#10
George Vassilakos, Anastassios Philippou, Michael Koutsilieris
OBJECTIVE: Insulin-like growth factor-1 (IGF-1) is a pleiotropic factor expressed in various tissues and plays a critical role in skeletal muscle physiology. Alternative splicing of the IGF-1 gene gives rise to different precursor polypeptides (isoforms) which could undergo post-translational cleavage, generating the common mature IGF-1 peptide and different carboxyl terminal extension (E-) peptides, with the fate of the latter being, so far, unknown. The objective if this study was to identify the IGF-1Ec forms or processing product(s), other than mature IGF-1, generated in different human and rodent tissues and particularly in human skeletal muscle after exercise-induced damage...
November 4, 2016: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/27826398/four-weeks-of-supplementation-with-isolated-soy-protein-attenuates-exercise-induced-muscle-damage-and-enhances-muscle-recovery-in-well-trained-athletes-a-randomized-trial
#11
Shweta Shenoy, Mrinal Dhawan, Jaspal Singh Sandhu
BACKGROUND: The effects of consumption of isolated soy protein (ISP) for a chronic period (4 weeks) on exercise induced muscle damage (EIMD) in athletic population have never been explored. OBJECTIVES: To examine the effects of ISP on muscle damage indices elicited via a bout of damaging exercise. PATIENTS AND METHODS: Forty males (20 boxers, 20 cyclists) aged 18 - 28 years were randomly assigned to two groups (ISP and Placebo) (n = 20). All participants who engaged themselves in specific, regular training of 30 hours a week during the competitive season were included in the study...
September 2016: Asian Journal of Sports Medicine
https://www.readbyqxmd.com/read/27821967/physical-and-balance-performance-following-exercise-induced-muscle-damage-in-male-soccer-players
#12
Muzaffar Ahmad Khan, Jamal Ali Moiz, Shahid Raza, Shalini Verma, M Y Shareef, Shahnawaz Anwer, Ahmad Alghadir
[Purpose] The present study aimed to determine the changes in physical and balance performance following exercise-induced muscle damage using a sport-specific protocol. [Subjects and Methods] Fifteen collegiate soccer players were asked to perform a sport-specific sprint protocol to induce muscle damage. The markers of muscle damage (soreness, range of motion, limb girth, muscle strength, creatine kinase and lactate dehydrogenase), physical performance (speed, agility and power) and balance (static and dynamic balance) were assessed at baseline and 24, 48 and 72 hours following the sprint protocol...
October 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27807525/longer-application-of-kinesio-taping-would-be-beneficial-for-exercise-induced-muscle-damage
#13
Jooyoung Kim, Seunghwan Kim, Joohyung Lee
Kinesio taping (KT) has been widely used to prevent muscle pain and to improve range of motion in clinical settings. However, no previous research has examined how long KT should be applied to muscle following damaging exercise. The aim of this study was to investigate the effect of the duration of KT application on markers of muscle damage following eccentric exercise. Thirty-two male subjects participated in the study and were randomly assigned to one of the following groups: control (CON), KT-post, KT-30 min, or KT-24 hr...
October 2016: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/27799809/insights-into-the-molecular-etiology-of-exercise-induced-inflammation-opportunities-for-optimizing-performance
#14
REVIEW
Ioannis G Fatouros, Athanasios Z Jamurtas
The study of exercise-induced muscle damage (EIMD) is of paramount importance not only because it affects athletic performance but also because it is an excellent model to study the mechanisms governing muscle cachexia under various clinical conditions. Although, a large number of studies have investigated EIMD and its associated inflammatory response, several aspects of skeletal muscles responses remain unclear. In the first section of this article, the mechanisms of EIMD are reviewed in an attempt to follow the events that result in functional and structural alterations of skeletal muscle...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27799464/muscle-injury-and-impaired-function-and-insulin-resistance-in-chromogranin-a-knockout-mice
#15
Kechun Tang, Teresa Pasqua, Angshuman Biswas, Sumana Mahata, Jennifer Tang, Alisa Tang, Gautam K Bandyopadhyay, Amiya Sinha-Hikim, Nai-Wen Chi, Nick Webster, Angelo Corti, Sushil K Mahata
Chromogranin A (CgA) is widely expressed in endocrine and neuroendocrine tissues as well as in the central nervous system. We observed CgA expression (mRNA and protein) in the gastrocnemius (GAS) muscle and found that performance of CgA-deficient Chga-KO mice in treadmill exercise was impaired. Supplementation with CgA in Chga-KO mice restored exercise ability suggesting a novel role for endogenous CgA in skeletal muscle function. Chga-KO mice display (i) lack of exercise-induced stimulation of pAKT, pTBC1D1 and phospho-p38 kinase signaling, (ii) loss of GAS muscle mass, (iii) extensive formation of tubular aggregates (TA), (iv) disorganized cristae architecture in mitochondria, (v) increased expression of the inflammatory cytokines Tnfα, Il6 and Ifnɣ, and fibrosis...
October 31, 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27798107/high-levels-of-sarcospan-are-well-tolerated-and-act-as-a-sarcolemmal-stabilizer-to-address-skeletal-muscle-and-pulmonary-dysfunction-in-dmd
#16
Elizabeth M Gibbs, Jamie L Marshall, Eva Ma, Thien M Nguyen, Grace Hong, Jessica Lam, Melissa J Spencer, Rachelle H Crosbie-Watson
Duchenne muscular dystrophy (DMD) is a genetic disorder that causes progressive muscle weakness, ultimately leading to early mortality in affected teenagers and young adults. Previous work from our lab has shown that a small transmembrane protein called sarcospan (SSPN) can enhance the recruitment of adhesion complex proteins to the cell surface. When human SSPN is expressed at three-fold levels in mdx mice, this increase in adhesion complex abundance improves muscle membrane stability, preventing many of the histopathological changes associated with DMD...
October 24, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27794509/effects-of-crude-hydroalcoholic-extract-of-syzygium-cumini-l-skeels-leaves-and-continuous-aerobic-training-in-rats-with-diabetes-induced-by-a-high-fat-diet-and-low-doses-of-streptozotocin
#17
G Baldissera, N D M Sperotto, H T Rosa, J G Henn, V F Peres, D J Moura, R Roehrs, E L G Denardin, P Dal Lago, R B Nunes, J Saffi
ETHNOPHARMACOLOGICAL RELEVANCE: The leaves of Syzygium cumini (L.) or Skeels (Myrtaceae) are widely used in Brazilian folk medicine to treat diabetes. AIM OF THE STUDY: The present study evaluated the functional capacity, biochemical parameters, oxidative stress and DNA damage from eight weeks of intervention with a crude hydroalcoholic extract of S. cumini leaves (EBH) and continuous aerobic training (TAC) in diabetic (D) rats. MATERIALS AND METHODS: A hydroalcoholic (50%) extract was prepared by ultrasound and phytochemical parameters (total phenols, total tannins and myricetin content) were analyzed...
October 26, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27784675/exercise-induced-alterations-and-loss-of-sarcomeric-m-line-organization-in-the-diaphragm-muscle-of-obscurin-knockout-mice
#18
Davide Randazzo, Bert Blaauw, Cecilia Paolini, Enrico Pierantozzi, Simone Spinozzi, Stephan Lange, Ju Chen, Feliciano Protasi, Carlo Reggiani, Vincenzo Sorrentino
We recently reported that skeletal muscle fibers of obscurin knockout (KO) mice present altered distribution of ankB, disorganization of the sub-sarcolemmal microtubules and reduced localization of dystrophin at costameres. In addition, these mice have impaired running endurance and increased exercise-induced sarcolemmal damage compared to wild-type animals. Here, we report results from a combined approach of physiological, morphological, and structural studies in which we further characterize the skeletal muscles of obscurin KO mice...
October 26, 2016: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/27782911/mechanisms-and-mediators-of-the-skeletal-muscle-repeated-bout-effect
#19
Robert D Hyldahl, Trevor C Chen, Kazunori Nosaka
Skeletal muscle adapts to exercise-induced damage by orchestrating several, but still poorly understood mechanisms that endow protection from subsequent damage. Known widely as the repeated bout effect, we propose that neural adaptations, alterations to muscle mechanical properties, structural remodeling of the extracellular matrix, and biochemical signaling work in concert to coordinate the protective adaptation.
October 25, 2016: Exercise and Sport Sciences Reviews
https://www.readbyqxmd.com/read/27770706/nrf2-mediates-redox-adaptations-to-exercise
#20
Aaron J Done, Tinna Traustadóttir
The primary aim of this review is to summarize the current literature on the effects of acute exercise and regular exercise on nuclear factor erythroid 2-related factor 2 (Nrf2) activity and downstream targets of Nrf2 signaling. Nrf2 (encoded in humans by the NFE2L2 gene) is the master regulator of antioxidant defenses, a transcription factor that regulates expression of more than 200 cytoprotective genes. Increasing evidence indicates that Nrf2 signaling plays a key role in how oxidative stress mediates the beneficial effects of exercise...
October 14, 2016: Redox Biology
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