Md Torikul Islam, Jinjin Cai, Shanena Allen, Denisse G Moreno, Samuel I Bloom, R Colton Bramwell, Jonathan Mitton, Andrew G Horn, Weiquan Zhu, Anthony J Donato, William L Holland, Lisa A Lesniewski
BACKGROUND: Much of what we know about insulin resistance is based on studies from metabolically active tissues such as the liver, adipose tissue, and skeletal muscle. Emerging evidence suggests that the vascular endothelium plays a crucial role in systemic insulin resistance; however, the underlying mechanisms remain incompletely understood. Arf6 (ADP ribosylation factor 6) is a small GTPase that plays a critical role in endothelial cell function. Here, we tested the hypothesis that the deletion of endothelial Arf6 will result in systemic insulin resistance...
March 28, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology