Kiana M Schulze, Andrew G Horn, Judy M Muller-Delp, Zachary J White, Stephanie E Hall, Steven L Medarev, Ramona E Weber, David C Poole, Timothy I Musch, Bradley J Behnke
Pulmonary hypertension (PH) is a chronic, progressive condition in which respiratory muscle dysfunction is a primary contributor to exercise intolerance and dyspnea in patients. Contractile function, blood flow distribution, and the hyperemic response are altered in the diaphragm with PH, and we sought to determine whether this may be attributed, in part, to impaired vasoreactivity of the resistance vasculature. We hypothesized that there would be blunted endothelium-dependent vasodilation and impaired myogenic responsiveness in arterioles from the diaphragm of PH rats...
April 11, 2024: Microvascular Research