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https://www.readbyqxmd.com/read/29234504/the-effects-of-low-intensity-blood-flow-restricted-exercise-compared-with-conventional-resistance-training-on-the-clinical-outcomes-of-active-uk-military-personnel-following-a-3-week-in-patient-rehabilitation-programme-protocol-for-a-randomized-controlled-feasibility
#1
Peter Ladlow, Russell J Coppack, Shreshth Dharm-Datta, Dean Conway, Edward Sellon, Stephen D Patterson, Alexander N Bennett
Background: A challenge for rehabilitation practitioners lies in designing optimal exercise programmes that facilitate musculoskeletal (MSK) adaptations whilst simultaneously accommodating biological healing and the safe loading of an injured limb. A growing body of evidence supports the use of resistance training at a reduced load in combination with blood flow restriction (BFR) to enhance hypertrophic and strength responses in skeletal muscle. In-patient rehabilitation has a long tradition in the UK Military, however, the efficacy of low intensity (LI) BFR training has not been tested in this rehabilitation setting...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29231621/-discussion-on-xuetou-xingzou-xuedao-ge-and-meridian-qi-flowing-cycle
#2
Min Chen
The xuetou xingzou xuedao ge is the representative for traumatic injury treated with acupoints of shaolin traumatology. It is mentioned that blood circulates to different acupoints in the governor vessel and the conception vessel at different time divisions a day. In the paper, the relationship is discussed between the blood circulation and the qi flowing cycle in the governor vessel, the conception vessel and the 12 regular meridians. It is found that the time for blood passing by at acupoint is closely related to the time division in meridian qi flowing...
May 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29221156/the-protective-role-of-sphingosine-1-phosphate-against-the-action-of-the-vascular-disrupting-agent-combretastatin-a-4-3-o-phosphate
#3
Joanna Shepherd, Matthew Fisher, Abigail Welford, Donald M McDonald, Chryso Kanthou, Gillian M Tozer
Solid tumours vary in sensitivity to the vascular disrupting agent combretastatin A-4 3-O-phosphate (CA4P), but underlying factors are poorly understood. The signaling sphingolipid, sphingosine-1-phosphate (S1P), promotes vascular barrier integrity by promoting assembly of VE-cadherin/β-catenin complexes. We tested the hypothesis that tumour pre-treatment with S1P would render tumours less susceptible to CA4P. S1P (1μM) pretreatment attenuated an increase in endothelial cell (HUVEC) monolayer permeability induced by 10μM CA4P...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29217510/loss-of-vascular-myogenic-tone-in-mir-143-145-knockout-mice-is-associated-with-hypertension-induced-vascular-lesions-in-small-mesenteric-arteries
#4
Johan Holmberg, Anirban Bhattachariya, Azra Alajbegovic, Catarina Rippe, Mari Ekman, Diana Dahan, Tran Thi Hien, Thomas Boettger, Thomas Braun, Karl Swärd, Per Hellstrand, Sebastian Albinsson
OBJECTIVE: Pressure-induced myogenic tone is involved in autoregulation of local blood flow and confers protection against excessive pressure levels in small arteries and capillaries. Myogenic tone is dependent on smooth muscle microRNAs (miRNAs), but the identity of these miRNAs is unclear. Furthermore, the consequences of altered myogenic tone for hypertension-induced damage to small arteries are not well understood. APPROACH AND RESULTS: The importance of smooth muscle-enriched microRNAs, miR-143/145, for myogenic tone was evaluated in miR-143/145 knockout mice...
December 7, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29215104/a-novel-ptp1b-inhibitor-extracted-from-ganoderma-lucidum-ameliorates-insulin-resistance-by-regulating-irs1-glut4-cascades-in-the-insulin-signaling-pathway
#5
Zhou Yang, Fan Wu, Yanming He, Qiang Zhang, Yuan Zhang, Guangrong Zhou, Hongjie Yang, Ping Zhou
Insulin resistance caused by the overexpression of protein tyrosine phosphatase 1 B (PTP1B) as well as the dephosphorylation of its target is one of the main causes of type 2 diabetes (T2D). A newly discovered proteoglycan, Fudan-Yueyang Ganoderma lucidum (FYGL) extracted from Ganoderma lucidum, was first reported to be capable of competitively inhibiting PTP1B activity in vitro in our previous work. In the present study, we sought to reveal the mechanism of PTP1B inhibition by FYGL at the animal and cellular levels...
December 7, 2017: Food & Function
https://www.readbyqxmd.com/read/29214460/blood-flow-restriction-late-in-recovery-after-heavy-resistance-exercise-hampers-muscle-recuperation
#6
Kestutis Bunevicius, Albinas Grunovas, Tomas Venckunas, Kristina Poderiene, Eugenijus Trinkunas, Jonas Poderys
PURPOSE: This study aimed to examine the effect of acute blood flow restriction during the late recovery phase between two resistance exercise bouts on muscular endurance and oxygenation. METHODS: Amateur male middle- and long-distance runners performed two bouts of one-leg dynamic plantar flexion exercise to failure with the load equivalent to 75% of maximum. Subjects were randomly assigned into two experimental groups with thigh occlusion pressure between bouts at either 120 or 200 mmHg with 20 min of passive rest in between, and two control groups without any blood flow restriction separated by either 5 or 20 min of rest...
December 6, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29214447/association-between-common-bile-duct-diameter-and-abdominal-aorta-calcium-score
#7
Yashar Moharamzad, Sahar Abbasi, Morteza Sanei Taheri, Taraneh Faghihi Langroudi
BACKGROUND AND OBJECTIVE: There is evidence of association between aging and increase in the normal upper limit of the common bile duct (CBD) diameter. As aging is a documented risk factor for atherosclerosis, and the possible effect that atherosclerosis can have on the CBD diameter via affecting its smooth muscle contractility and blood flow, we decided to determine the association between CBD diameter and atherosclerosis in the abdominal aorta (AA). METHODS: A total of 99 asymptomatic patients (53 males and 46 females; age range of 18-88 years) without history of cholecystectomy who underwent abdominal contrast-enhanced CT scan were included...
December 6, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29213129/deep-tissue-analysis-of-distal-aqueous-drainage-structures-and-contractile-features
#8
Jose M Gonzalez, Minhee K Ko, Young-Kwon Hong, Robert Weigert, James C H Tan
Outflow resistance in the aqueous drainage tract distal to trabecular meshwork is potentially an important determinant of intraocular pressure and success of trabecular bypass glaucoma surgeries. It is unclear how distal resistance is modulated. We sought to establish: (a) multimodal 2-photon deep tissue imaging and 3-dimensional analysis of the distal aqueous drainage tract (DT) in transgenic mice in vivo and ex vivo; (b) criteria for distinguishing the DT from blood and lymphatic vessels; and (c) presence of a DT wall organization capable of contractility...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29209423/the-physiological-effects-of-slow-breathing-in-the-healthy-human
#9
Marc A Russo, Danielle M Santarelli, Dean O'Rourke
Slow breathing practices have been adopted in the modern world across the globe due to their claimed health benefits. This has piqued the interest of researchers and clinicians who have initiated investigations into the physiological (and psychological) effects of slow breathing techniques and attempted to uncover the underlying mechanisms. The aim of this article is to provide a comprehensive overview of normal respiratory physiology and the documented physiological effects of slow breathing techniques according to research in healthy humans...
December 2017: Breathe
https://www.readbyqxmd.com/read/29206970/thrombospondin-1-and-disease-progression-in-dysferlinopathy
#10
Norifumi Urao, Rita E Mirza, Thomas F Corbiere, Zsuzsanna Hollander, Christoph H Borchers, Timothy J Koh
The purpose of this study was to determine whether thrombospondin (TSP)-1 promotes macrophage activity and disease progression in dysferlinopathy. First, we found that levels of TSP-1 are elevated in blood of non-ambulant dysferlinopathy patients compared with ambulant patients and healthy controls, supporting the idea that TSP-1 levels are correlated with disease progression. We then crossed dysferlinopathic BlaJ mice with TSP-1 knockout mice and assessed disease progression longitudinally with magnetic resonance imaging (MRI)...
December 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29203629/exaggerated-vasoconstriction-to-spontaneous-bursts-of-muscle-sympathetic-nerve-activity-in-healthy-young-black-men
#11
Jennifer R Vranish, Seth W Holwerda, Benjamin E Young, Daniel P Credeur, Jordan C Patik, Thales C Barbosa, David M Keller, Paul J Fadel
Blacks have the highest prevalence of hypertension, putting them at greater risk of cardiovascular disease and death. Previous studies have reported that, relative to whites, healthy black men have augmented pressor responses to sympathoexcitatory stressors. Although important, these studies do not inform about the resting state and the influence of spontaneous changes in resting muscle sympathetic nerve activity (MSNA). Likewise, little is known about the transduction of MSNA into a vascular response at rest on a beat-to-beat basis...
December 4, 2017: Hypertension
https://www.readbyqxmd.com/read/29202457/recapitulation-of-developmental-mechanisms-to-revascularize-the-ischemic-heart
#12
Karina N Dubé, Tonia M Thomas, Sonali Munshaw, Mala Rohling, Paul R Riley, Nicola Smart
Restoring blood flow after myocardial infarction (MI) is essential for survival of existing and newly regenerated tissue. Endogenous vascular repair processes are deployed following injury but are poorly understood. We sought to determine whether developmental mechanisms of coronary vessel formation are intrinsically reactivated in the adult mouse after MI. Using pulse-chase genetic lineage tracing, we establish that de novo vessel formation constitutes a substantial component of the neovascular response, with apparent cellular contributions from the endocardium and coronary sinus...
November 16, 2017: JCI Insight
https://www.readbyqxmd.com/read/29199462/role-of-genetics-in-peripheral-arterial-disease-outcomes-significance-of-limb-salvage-quantitative-locus-1-genes
#13
Emmanuel Okeke, Ayotunde O Dokun
Peripheral artery disease is a major health care problem with significant morbidity and mortality. Humans with peripheral artery disease exhibit two major and differential clinical manifestations - intermittent claudication and critical limb ischemia. Individuals with intermittent claudication or critical limb ischemia have overlapping risk factors and objective measures of blood flow. Hence, we hypothesized that variation in genetic make-up may be an important determinant in the severity of peripheral artery disease...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29195509/dpp-4-inhibition-with-linagliptin-ameliorates-the-progression-of-premature-aging-in-klotho-mice
#14
Yu Hasegawa, Kenyu Hayashi, Yushin Takemoto, Cao Cheng, Koki Takane, Bowen Lin, Yoshihiro Komohara, Shokei Kim-Mitsuyama
BACKGROUND: The potential of anti-aging effect of DPP-4 inhibitors is unknown. This study was performed to determine whether linagliptin, a DPP-4 inhibitor, could protect against premature aging in klotho-/- mice. METHODS: Klotho-/- mice exhibit multiple phenotypes resembling human premature aging, including extremely shortened life span, cognitive impairment, hippocampal neurodegeneration, hair loss, muscle atrophy, hypoglycemia, etc. To investigate the effect of linagliptin on these aging-related phenotypes, male klotho-/- mice were divided into two groups: (1) control group fed the standard diet, and (2) linagliptin group fed the standard diet containing linagliptin...
December 1, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29186390/direct-activation-of-the-angiotensin-ii-type-2-receptors-enhances-muscle-microvascular-perfusion-oxygenation-and-insulin-delivery-in-male-rats
#15
Fei Yan, Zhaoshun Yuan, Nasui Wang, Robert M Carey, Kevin W Aylor, Li Chen, Xinmin Zhou, Zhenqi Liu
Angiotensin II receptors regulate muscle microvascular recruitment and the delivery of nutrients, oxygen and insulin to muscle. While the angiotensin type-1 receptor antagonism increases muscle microvascular perfusion and insulin action, angiotensin type-2 receptor blockade markedly restricts muscle microvascular blood volume and decreases muscle delivery of insulin. To examine the effects of direct type-2 receptor stimulation using Compound 21 (C21) on microvascular perfusion, insulin delivery and action, and tissue oxygenation in muscle, overnight fasted adult male rats were infused with C21 systemically...
November 24, 2017: Endocrinology
https://www.readbyqxmd.com/read/29184265/long-term-low-intensity-endurance-exercise-along-with-blood-flow-restriction-improves-muscle-mass-and-neuromuscular-junction-compartments-in-old-rats
#16
Mohammad-Ali Bahreini Pour, Siyavash Joukar, Fariborz Hovanloo, Hamid Najafipour
Background: During the aging process, muscle atrophy and neuromuscular junction remodeling are inevitable. The present study aimed to clarify whether low-intensity aerobic exercise along with limb blood-flow restriction (BFR) could improve aging-induced muscle atrophy and nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. Methods: Forty-eight male Wistar rats, aged 23-24 months, were randomly divided into control, sham (Sh: subjected to surgery without BFR), BFR (subjected to BFR), exercise (Ex: subjected to 10 weeks of low-intensity exercise), Sh+Ex, and BFR+Ex groups...
November 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29180215/analysis-of-ischemic-muscle-in-patients-with-peripheral-artery-disease-using-x-ray-spectroscopy
#17
Ryan A Becker, Kim Cluff, Nithyanandhi Duraisamy, George P Casale, Iraklis I Pipinos
BACKGROUND: Peripheral artery disease (PAD) is a vascular disease caused by atherosclerosis, resulting in decreased blood flow to the lower extremities. The ankle-brachial index (ABI) is a standard PAD diagnostic test but only identifies reduced blood flow based on blood pressure differences. The early signs of PAD manifest themselves not only at a clinical level but also at an elemental and biochemical level. However, the biochemical and elemental alterations to PAD muscle are not well understood...
December 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29179622/traumatic-brain-injury-impairs-myogenic-constriction-of-cerebral-arteries-role-of-mitochondria-derived-h2o2-and-trpv4-dependent-activation-of-bkca-channels
#18
Nikolett Szarka, Mallikarjuna R Pabbidi, Krisztina Amrein, Endre Czeiter, Gergely Berta, Krisztina Pohoczky, Zsuzsanna Helyes, Zoltan Ungvari, Akos Koller, Andras Buki, Peter Toth
Traumatic brain injury (TBI) impairs autoregulation of cerebral blood flow, which contributes to the development of secondary brain injury increasing mortality of patients. Impairment of pressure-induced myogenic constriction of cerebral arteries plays a critical role in autoregulatory dysfunction; however, the underlying cellular and molecular mechanisms are not well understood. To determine the role of mitochondria-derived H2O2 and large-conductance calcium-activated potassium channels (BKCa) in myogenic autoregulatory dysfunction, middle cerebral arteries (MCAs) were isolated from rats with severe weight drop-impact acceleration brain injury (24 h post-impact)...
November 27, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29172012/do-whole-body-vibration-exercises-affect-lower-limbs-neuromuscular-activity-in-populations-with-a-medical-condition-a-systematic-review
#19
Carla Fontoura Dionello, Patrícia Lopes de Souza, Danubia Sá-Caputo, Danielle Soares Morel, Eloá Moreira-Marconi, Laisa Liane Paineiras-Domingos, Eric Heleno Freire Ferreira Frederico, Eliane Guedes-Aguiar, Patricia de Castro Paiva, Redha Taiar, Xavier Chiementin, Pedro J Marín, Mario Bernardo-Filho
BACKGROUND: The use of surface electromyography (sEMG) to evaluate muscle activation when executing whole body vibration exercises (WBVE) in studies provide neuromuscular findings, in healthy and diseased populations. OBJECTIVES: Perform a systematic review of the effects of WBVE by sEMG of lower limbs in non-healthy populations. METHODS: The search using the defined keywords was performed in PubMed, PEDRo and EMBASE databases by three independent researchers...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29170451/chemokines-protect-vascular-smooth-muscle-cells-from-cell-death-induced-by-cyclic-mechanical-stretch
#20
Jing Zhao, Yuhei Nishimura, Akihiko Kimura, Kentaro Ozawa, Toshikazu Kondo, Toshio Tanaka, Masanori Yoshizumi
The pulsatile nature of blood flow exposes vascular smooth muscle cells (VSMCs) in the vessel wall to cyclic mechanical stretch (CMS), which evokes VSMC proliferation, cell death, phenotypic switching, and migration, leading to vascular remodeling. These responses have been observed in many cardiovascular diseases; however, the underlying mechanisms remain unclear. We have revealed that CMS of rat aortic smooth muscle cells (RASMCs) causes JNK- and p38-dependent cell death and that a calcium channel blocker and angiotensin II receptor antagonist decreased the phosphorylation of JNK and p38 and subsequently decreased cell death by CMS...
November 23, 2017: Scientific Reports
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