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Femoral artery blood flow

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https://www.readbyqxmd.com/read/28302707/neuropeptide-y3-36-incorporated-into-pvax-nanoparticle-improves-functional-blood-flow-in-a-murine-model-of-hind-limb-ischemia
#1
Derek Eshun, Rabya Saraf, Soochan Bae, Jelliffe Jeganathan, Feroze Mahmood, Serkan Dilmen, Qingen Ke, Dongwon Lee, Peter M Kang, Robina Matyal
We generated a novel nanoparticle called PVAX, which has intrinsic anti-apoptotic and anti-inflammatory properties. This nanoparticle was loaded with Neuropeptide Y3-36, an angiogenic neuro-hormone that plays a central role in angiogenesis. Subsequently, we investigated whether PVAX-NPY3-36 could act as a therapeutic agent and induce angiogenesis and vascular remodeling in a murine model of hind limb ischemia. Adult C57BL/J6 mice (n=40) were assigned to treatment groups: Control, Ischemia PBS, Ischemia PVAX, Ischemia NPY3-36, and Ischemia PVAX-NPY3-36 Ischemia was induced by ligation of the femoral artery in all groups except Control and given relevant treatments (PBS, PVAX, NPY3-36, and PVAX-NPY3-36)...
March 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28273102/age-related-differences-in-skeletal-muscle-microvascular-response-to-exercise-as-detected-by-contrast-enhanced-ultrasound-ceus
#2
Wulf Hildebrandt, Hans Schwarzbach, Anita Pardun, Lena Hannemann, Björn Bogs, Alexander M König, Andreas H Mahnken, Olaf Hildebrandt, Ulrich Koehler, Ralf Kinscherf
BACKGROUND: Aging involves reductions in exercise total limb blood flow and exercise capacity. We hypothesized that this may involve early age-related impairments of skeletal muscle microvascular responsiveness as previously reported for insulin but not for exercise stimuli in humans. METHODS: Using an isometric exercise model, we studied the effect of age on contrast-enhanced ultrasound (CEUS) parameters, i.e. microvascular blood volume (MBV), flow velocity (MFV) and blood flow (MBF) calculated from replenishment of Sonovue contrast-agent microbubbles after their destruction...
2017: PloS One
https://www.readbyqxmd.com/read/28245772/structure-of-atherosclerotic-plaques-in-different-vascular-territories-clinical-relevance
#3
Pavel Poredos, Peter Poredos, Mateja Kaja Jezovnik
Atherosclerosis is a systemic disease with different faces. Despite similar, or even identical, risk factors and pathogenesis, atherosclerotic lesions and their clinical manifestations vary in different parts of the vasculature. Peripheral arterial disease (PAD) in the superficial femoral artery (SFA) represents a frequent clinical manifestations of atherosclerotic disease. The pathohistological characteristics of plaques in PAD differ from lesions in the coronary arteries. Plaques in the SFA have more fibrotic elements with less lipid and degenerative tissue elements; this makes them more stable and less prone to rupture...
February 26, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28231351/evaluation-of-hemodynamics-in-a-prestressed-and-compliant-tapered-femoral-artery-using-an-optimization-based-inverse-algorithm
#4
Rupak K Banerjee, Gavin A D'Souza, Anup K Paul, Ashish Das
The important factors that affect the arterial wall compliance are the tissue properties of the arterial wall, the in vivo pulsatile pressure, and the prestressed condition of the artery. It is necessary to obtain the load-free geometry for determining the physiological level of prestress in the arterial wall. The previously developed optimization-based inverse algorithm was improved to obtain the load-free geometry and the wall prestress of an idealized tapered femoral artery of a dog under varying arterial wall properties...
April 1, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28228367/blockade-of-hmgb1-preserves-vascular-homeostasis-and-improves-blood-perfusion-in-rats-of-acute-limb-ischemia-reperfusion
#5
Yang Liu, Changyou Zhou, Jianjun Jiang, Qingbo Su, Xiangjiu Ding
Acute limb ischemia is one of the most common peripheral arterial disease, while surgical restoration of blood flow often results in ischemia/reperfusion (I/R) injury. Our previous study revealed the inflammation intensity in arterial tissue, characterized by expression of high mobility group box protein 1 (HMGB1), was contrary to the fluctuation of hemodynamics in reperfusion limbs in a rat model. This study meant to clarify the role of HMGB1 during this process. Laser Doppler perfusion imaging evaluated limb hemodynamics in mean and max perfusion unit (PU)...
February 21, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28193707/arterial-pressure-heart-rate-and-cerebral-hemodynamics-across-the-adult-life-span
#6
Chang-Yang Xing, Takashi Tarumi, Rutger L Meijers, Marcel Turner, Justin Repshas, Li Xiong, Kan Ding, Wanpen Vongpatanasin, Li-Jun Yuan, Rong Zhang
Age-related alterations in systemic and cerebral hemodynamics are not well understood. The purpose of this study is to characterize age-related alterations in beat-to-beat oscillations in arterial blood pressure (BP), heart rate (HR), cerebral blood flow (CBF), cardiac baroreflex sensitivity, and dynamic cerebral autoregulation across the adult life span. We studied 136 healthy adults aged 21 to 80 years (60% women). Beat-to-beat BP, HR, and CBF velocity were measured at rest and during sit-stand maneuvers to mimic effects of postural changes on BP and CBF...
April 2017: Hypertension
https://www.readbyqxmd.com/read/28165556/complicated-thoraco-abdominal-aortic-dissection-presenting-with-lower-limb-ischemia-in-a-patient-with-bovine-arch-and-arteria-lusoria
#7
G-R Joliat, C Dubuis, S Déglise
We report the case of a 58-year-old man who presented with thoraco-abdominal pain and right lower limb ischemia due to type B aortic dissection. Moreover, the patient was discovered to have several concomitant aortic arch anomalies (bovine arch, arteria lusoria, and left vertebral artery arising from the aortic arch). Taking into account this complex anatomy, emergent femoral exploration with fenestration and thrombectomy was performed. The blood flow to the right lower limb was restored. A few days later the aortic dissection spread proximally, and the aortic arch dilatation enlarged...
January 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28160266/investigation-of-stent-implant-mechanics-using-linear-analytical-and-computational-approach
#8
Hua Yang, Aleksandra Fortier, Kyle Horne, Atif Mohammad, Subhash Banerjee, Hai-Chao Han
Stent implants are essential in restoring normal blood flow in atherosclerotic arteries. Recent studies have shown high failure rates of stent implants in superficial femoral artery (SFA) as a result of dynamic loading environment imposed on the stent implants by the diseased arterial wall and turbulent blood flow. There are variety of stent designs and materials currently on the market however, there is no clear understanding if specific stent design is suitable with the material that is manufactured from and if this combination can sustain the life-cycle that the stent implants need to undergo once inside the artery...
February 3, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28155247/flow-mediated-dilation-assessment-in-the-superficial-femoral-artery-using-a-sustained-shear-stress-stimulus-via-calf-plantar-flexion-exercise
#9
T J King, S M Schmitter, K E Pyke
The superficial femoral artery (SFA) is susceptible to vascular disease, and a technique to assess flow mediated dilation (FMD) in this vessel in response to a sustained shear stress stimulus could provide important information about endothelial function. PURPOSE: To establish the ability of a newly designed SFA leg exercise-FMD (LEX-FMD) technique to produce sustained elevations in shear rate which stimulate FMD, and to determine the repeat trial stability of the FMD response. METHODS: SFA FMD stimulated by reactive hyperemia (RH) and calf plantar-flexion exercise (LEX) was assessed via ultrasound in 19 healthy men (n = 10) and women (n = 9)...
February 2, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28154161/development-of-coronary-pulse-wave-velocity-new-pathophysiological-insight-into-coronary-artery-disease
#10
Brahim Harbaoui, Pierre-Yves Courand, Andrei Cividjian, Pierre Lantelme
BACKGROUND: Although aortic stiffness assessed by pulse wave velocity (PWV) is a strong predictor of coronary artery disease, the significance of local coronary stiffness has never been tackled. The first objective of this study was to describe a method of measuring coronary PWV (CoPWV) invasively and to describe its determinants. The second objective was to assess both CoPWV and aortic PWV in patients presenting with acute coronary syndromes or stable coronary artery disease. METHODS AND RESULTS: In 53 patients, CoPWV was measured from the delay in pressure wave and distance traveled as a pressure wire was withdrawn from the distal to the proximal coronary segment...
February 2, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28141620/cold-water-mediates-greater-reductions-in-limb-blood-flow-than-whole-body-cryotherapy
#11
Chris Mawhinney, David A Low, Helen Jones, Daniel J Green, Joseph T Costello, Warren Gregson
PURPOSE: Cold-water immersion (CWI) and whole body cryotherapy (WBC) are widely used recovery methods in an attempt to limit exercise-induced muscle damage, soreness and functional deficits after strenuous exercise. The aim of this study was to compare the effects of ecologically-valid CWI and WBC protocols on post-exercise lower limb thermoregulatory, femoral artery and cutaneous blood flow responses. METHODS: Ten males completed a continuous cycle exercise protocol at 70% maximal oxygen uptake until a rectal temperature of 38°C was attained...
January 30, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28109110/-effects-of-polyethylene-oxide-on-blood-perfusion-in-the-hind-limbs-of-rats-with-chronic-hindlimb-ischemia
#12
De-Zhong Zheng, Tao Zhou, Dao-Gang Zha
OBJECTIVE: To evaluate the effects of polyethylene oxide (PEO) on blood perfusion in hind limb skeletal muscles in a rat model of chronic hind limb ischemia. METHDOS: Twelve rat models of chronic hind limb ischemia established by unilateral femoral artery ligation were randomized into PEO and control groups (n=6) and treated with intravenous infusion of PEO and saline through the internal jugular vein every other day for 2 weeks. Contrast-enhanced ultrasonography was performed after the treatments to evaluate the blood flow in the skeletal muscles at different time points and blood flow reserve in the ischemic hind limbs on day 28...
January 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28100130/influence-of-cold-water-immersion-on-limb-blood-flow-after-resistance-exercise
#13
Chris Mawhinney, Helen Jones, David A Low, Daniel J Green, Glyn Howatson, Warren Gregson
This study determined the influence of cold (8°C) and cool (22°C) water immersion on lower limb and cutaneous blood flow following resistance exercise. Twelve males completed 4 sets of 10-repetition maximum squat exercise and were then immersed, semi-reclined, into 8°C or 22°C water for 10-min, or rested in a seated position (control) in a randomized order on different days. Rectal and thigh skin temperature, muscle temperature, thigh and calf skin blood flow and superficial femoral artery blood flow were measured before and after immersion...
January 19, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28074808/demonstration-of-blood-flow-by-color-doppler-in-the-femoral-artery-distal-to-arterial-cannula-during-peripheral-venoarterial-extracorporeal-membrane-oxygenation
#14
K G Suresh Rao, T Muralikrishna, K R Balakrishnan
In spite of distal perfusion of the limb using a cannula, the limb can have ischemic events if there is an undetected kink or clot anywhere in the line or thrombus in the artery. There are several ways to monitor and assess the limb ischemia. Monitoring for clinical signs of limb ischemia like temperature change and pallor is reliable and mandatory. We report a method where we used color Doppler to document the blood flow. Curvilinear vascular probe of an echo machine is used to identify the flow in the distal femoral artery of the lower limb...
January 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28054454/epoetin-beta-pegol-ameliorates-flow-mediated-dilation-with-improving-enos-coupling-state-in-non-obese-diabetic-rats
#15
Kenichi Serizawa, Kenji Yogo, Yoshihito Tashiro, Ryohei Kawasaki, Koichi Endo, Yasushi Shimonaka, Michinori Hirata
BACKGROUND/AIMS: Patients with diabetic nephropathy have a high cardiovascular mortality. Epoetin beta pegol (continuous erythropoietin receptor activator, C.E.R.A.) is a drug for the treatment of renal anemia. In this study, we investigated the effect of C.E.R.A. on vascular endothelial function as evaluated by flow-mediated dilation (FMD) and the relationship between hematopoiesis and FMD in diabetic nephropathy rats. METHODS: Male Spontaneously Diabetic Torii rats (SDT, 22 weeks old) were used...
January 5, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28046185/technical-note-measurement-of-mammary-plasma-flow-in-sows-by-downstream-dilution-of-mammary-vein-infused-aminohippuric-acid
#16
U Krogh, A C Storm, P K Theil
The objectives of the present study were to design a method to estimate mammary plasma flow (MPF) in lactating sows using downstream dilution of -aminohippuric acid (AH) and to compare these estimates with MPF estimates based on specific AA as internal markers (MPF-AA). A permanent indwelling catheter was surgically implanted in the femoral artery, and another 2 were inserted in the right cranial mammary vein of 8 second- and third-parity sows on d 76 ± 2 SEM of gestation. On the 3rd and 17th days in milk, arterial and venous blood samples were drawn in hourly intervals from 0...
December 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27998712/impacts-of-femoral-artery-and-vein-excision-versus-femoral-artery-excision-on-the-hindlimb-ischemic-model-in-cd-1-mice
#17
Miao Chen, Huimin Fan, Benjamin T Ledford, Zayd Farah, Catherine Barron, Zhongmin Liu, Jia-Qiang He
BACKGROUND AND AIM: Although femoral artery ligation-induced ischemia is commonly used in C57BL/6 or Balb/c mice, direct comparisons between femoral artery/vein (FAV) versus femoral artery (FA) excisions have not been reported. The goal of the present study is to investigate the effects of FAV versus FA excisions on hindlimb models using adult CD-1 mice. METHODS: Two groups (n=10/group) of adult, mixed gender CD-1 mice were used to generate hindlimb ischemic models by excising either the FAV or FA...
December 18, 2016: Microvascular Research
https://www.readbyqxmd.com/read/27998245/generation-endothelialization-and-microsurgical-suture-anastomosis-of-strong-1-mm-diameter-collagen-tubes
#18
Xuanyue Li, Jing Xu, Calin T Nicolescu, Jordann T Marinelli, Joe Tien
Tissue-engineered vascular grafts that are based on reconstituted extracellular matrices have been plagued by weak mechanical strength that prevents handling or anastomosis to native vessels. In this study, we devise a method for making dense, suturable collagen tubular constructs of diameter ≤1 mm for potential microsurgical applications, by dehydrating tubes of native rat tail type I collagen and crosslinking them with 20 mM genipin. Crosslinked dense collagen tubes with 1 mm inner diameter yielded ultimate tensile strength of 342 ± 15 gF and burst pressure of 1313 ± 156 mm Hg, comparable to the strength of a rat femoral artery, and supported endothelial cell adhesion and growth...
January 13, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27987329/fetal-alcohol-exposure-alters-blood-flow-and-neurological-responses-to-transient-cerebral-ischemia-in-adult-mice
#19
Shameena Bake, Rachel Gardner, Joseph D Tingling, Rajesh C Miranda, Farida Sohrabji
BACKGROUND: Prenatal alcohol exposure (PAE) can result in physical and neurocognitive deficits that are collectively termed "fetal alcohol spectrum disorders" (FASD). Although FASD is associated with lifelong intellectual disability, the mechanisms mediating the emergence of secondary mental health and physical disabilities are poorly understood. Based on our previous data showing that maternal ethanol (EtOH) exposure in mice resulted in an immediate reduction in cranially directed fetal blood flow, we hypothesized that such exposure would also result in persistent alterations in cranially directed blood flow in the prenatally alcohol-exposed (PAE) adult...
January 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27965589/m-currents-kv7-2-7-3-kcnq2-kcnq3-are-responsible-for-dysfunctional-autonomic-control-in-hypertensive-rats
#20
Torill Berg
Autonomic dysfunctions play important roles in hypertension, heart failure and arrhythmia, often with a detrimental and fatal effect. The present study analyzed if these dysfunctions involved M-channels (members of the Kv7/KNCQ family) in spontaneously hypertensive rats (SHR). Cardiac output and heart rate (HR) were recorded by a flow probe on the ascending aorta in anesthetized SHR and normotensive rats (WKY), and blood pressure (BP) by a femoral artery catheter. Total peripheral vascular resistance (TPR) was calculated...
2016: Frontiers in Physiology
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