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Femoral artery blood flow

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https://www.readbyqxmd.com/read/28933121/-effect-of-naoxintong-capsule-on-endothelial-progenitor-cell-mobilization-and-homing-following-bone-marrow-transplantation-in-a-mouse-hind-limb-ischemia-model
#1
Li-Zhen Qiu, Lu Chen, Chun-Xiao Li, Xiao Geng, Xing-Yu You, Lu-Sha Zhang, Hong Wang
Endothelial progenitor cells (EPCs) are precursor cells of endothelial cells. Signal molecules produced by ischemia and hypoxia can promote mobilization of bone marrow EPCs to peripheral circulation and formation of novel blood vessels in tissues that are damaged during heart attack. Naoxintong capsule (NXT) has the functions of promoting blood circulation, removing blood stasis, promoting the circulation of qi and relieving pain. The various components in NXT have protective effects on blood vessels and can effectively improve the symptoms of ischemia...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28930095/robust-and-practical-non-invasive-estimation-of-local-arterial-wave-speed-and-mean-blood-velocity-waveforms
#2
Remi Kowalski, Richard Beare, Marie Willemet, Jordi Alastruey, Joseph J Smolich, Michael M H Cheung, Jonathan P Mynard
Local arterial wave speed, a surrogate of vessel stiffness, can be estimated via the pressure-velocity (PU) and diameter-velocity (ln(D)U) loop methods. These assume negligible early-systolic reflected waves (RWes) and require measurement of cross-sectionally averaged velocity (U<sub>mean</sub>), which itself is a valuable quantity related to volumetric blood flow. However, RWes may not always be negligible and routine Doppler ultrasound typically provides maximum velocity waveforms or estimates of mean velocity subject to various errors (U<sub>raw</sub>)...
September 20, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28917976/low-molecular-weight-fucoidan-ameliorates-hindlimb-ischemic-injury-in-type-2-diabetic-rats
#3
Zhiqiang Wang, Tiantian Liu, Xiaoping Chen, Hongjie You, Quanbin Zhang, Jingyi Xue, Yuanyuan Zheng, Dali Luo
ETHNOPHARMACOLOGICAL RELEVANCE: Low molecular weight fucoidan (LMWF), extracted from Laminaria japonica Areschoug, is a traditional Chinese medicine, commonly used to alleviate edema, particularly for feet with numbness and pain. AIM OF THE STUDY: Diabetic mellitus (DM) patients are at high risk of developing peripheral arterial disease (PAD). Individuals with DM and PAD co-morbidity have a much higher risk of critical limb ischemia. LMWF showed several beneficial effects, such as anti-inflammation, anti-thrombosis, and enhancing revascularization...
September 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28914827/-endovascular-surgery-for-critical-ischemia-of-lower-extremities-with-suppurative-necrotic-lesion-of-the-feet
#4
K V Lipatov, S V Permyakov, A G Asatryan, A V Borodin, V K Gostishchev
AIM: To improve treatment of patients with grade IV chronic ischemia of lower extremities via endovascular angioplasty combined with surgical methods for suppurative-necrotic lesions of the feet. MATERIAL AND METHODS: 51 patients with grade IV chronic ischemia of lower extremities underwent endovascular interventions (balloon angioplasty, stenting). A total of 23 stents were deployed in 16 patients including 12 stents in superficial and common femoral arteries, 5 in popliteal artery, 6 in iliac artery...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28900861/acute-kidney-injury-caused-by-decompression-illness-successfully-treated-with-hyperbaric-oxygen-therapy-and-temporary-dialysis
#5
Arata Hibi, Keisuke Kamiya, Takahisa Kasugai, Keisuke Kamiya, Satoru Kominato, Chiharu Ito, Toshiyuki Miura, Katsushi Koyama
A 52-year-old Japanese male professional diver was referred to our hospital for decompression illness (DCI). After 1 h of diving operation at 20 m below sea level, he complained of dyspnea, chest pain, and abdominal pain. He dove again, intending to ease the symptoms, but the symptoms were never relieved. He dove for a total of 4 h. No neurological abnormalities were observed. Computed tomography images revealed portal venous gas and mesenteric venous gas, in addition to bubbles in the femoral veins, pelvis, lumbar canal, intracranial sinuses, and joints...
September 12, 2017: CEN Case Reports
https://www.readbyqxmd.com/read/28900624/ultrasound-mediated-microbubbles-destruction-augmented-sonolysis-an-in-vitro-and-in-vivo-study
#6
Hai Cui, Qiong Zhu, Yunhua Gao, Hongmei Xia, Kaibin Tan, Ying He, Zheng Liu, Yali Xu
OBJECTIVE: This study was aimed at exploring ultrasound mediated microbubbles destruction (UMMD) assisted sonolysis in both the in vitro and in vivo clots. METHODS: Therapeutic ultrasound (TUS) and lipid microbubbles (MBs) were used in whole blood clots and divided into the control, TUS group, and TUS + MB group. Thrombolytic rates and microscopy were performed. Color Doppler flow imaging (CDFI) and angiography were performed to evaluate the recanalization rates and flow scores in femoral arterial thrombus (FAT) in rabbits...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28878099/distal-cuff-occlusion-a-novel-simple-approach-for-distal-embolic-protection-in-peripheral-vascular-intervention
#7
Shwan Jalal, Jihad A Mustapha, Howard S Rosman, Rajendra H Mehta, Thomas P Davis
AIM: To evaluate the feasibility, effectiveness, and safety of the cuff-occlusion method for distal embolic protection in peripheral artery disease. METHODS AND RESULTS: We evaluated 61 patients who underwent peripheral vascular intervention (PVI) for infrainguinal lesion at a single center where a blood pressure cuff occlusion method for distal embolic protection was utilized during the procedure. Primary endpoint included incidence of distal embolization, acute limb ischemia, or emergency limb amputation...
September 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28872119/intravital-microscopy-of-monocyte-homing-and-tumor-related-angiogenesis-in-a-murine-model-of-peripheral-arterial-disease
#8
Martin Wagner, Claudia Baer, Werner Zuschratter, Monika Riek-Burchardt, Christian Deffge, Soenke Weinert, Jerry C Lee, Ruediger C Braun-Dullaeus, Joerg Herold
The therapeutic goal for peripheral arterial disease and ischemic heart disease is to increase blood flow to ischemic areas caused by hemodynamic stenosis. Vascular surgery is a viable option in selected cases, but for patients without indications for surgery such as progression to rest pain, critical limb ischemia, or major disruptions to life or work, there are few possibilities for mitigating their disease. Cell therapy via monocyte-enhanced perfusion through the stimulation of collateral formation is one of a few non-invasive options...
August 26, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28869535/mitochondrial-targeted-antioxidant-maintains-blood-flow-mitochondrial-function-and-redox-balance-in-old-mice-following-prolonged-limb-ischemia
#9
Shunsuke Miura, Shu-Ichi Saitoh, Tomoki Kokubun, Takashi Owada, Hiroyuki Yamauchi, Hirofumi Machii, Yasuchika Takeishi
Aging is a major factor in the decline of limb blood flow with ischemia. However, the underlying mechanism remains unclear. We investigated the role of mitochondrial reactive oxygen species (ROS) with regard to limb perfusion recovery in aging during ischemia. We performed femoral artery ligation in young and old mice with or without treatment with a scavenger of mitochondrial superoxide, MitoTEMPO (180 μg/kg/day, from pre-operative day 7 to post-operative day (POD) 21) infusion using an implanted mini-pump...
September 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28860173/single-passive-leg-movement-assessment-of-vascular-function-the-contribution-of-nitric-oxide
#10
Ryan M Broxterman, Joel D Trinity, Jayson R Gifford, Oh Sung Kwon, Andrew C Kithas, Jay R Hydren, Ashley D Nelson, David E Morgan, Jacob E Jessop, Amber D Bledsoe, Russell S Richardson
The assessment of passive leg movement (PLM)-induced leg blood flow (LBF) and vascular conductance (LVC) is a novel approach to assess vascular function, which has recently been simplified to only a single PLM (sPLM), thereby increasing the clinical utility of this technique. As the physiological mechanisms mediating the robust increase in LBF and LVC with sPLM are currently unknown, we tested the hypothesis that nitric oxide (NO) is a major contributor to the sPLM-induced LBF and LVC response. In nine healthy men, sPLM was performed with and without the inhibition of nitric oxide synthase (NOS) via intra-arterial infusion of N(G)-monomethyl-L-arginine (L-NMMA)...
August 31, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28853610/white-matter-hyperintensities-in-migraine-clinical-significance-and-central-pulsatile-hemodynamic-correlates
#11
Chun-Yu Cheng, Hao-Min Cheng, Shih-Pin Chen, Chih-Ping Chung, Yung-Yang Lin, Han-Hwa Hu, Chen-Huan Chen, Shuu-Jiun Wang
Background The role of central pulsatile hemodynamics in the pathogenesis of white matter hyperintensities in migraine patients has not been clarified. Methods Sixty patients with migraine (20-50 years old; women, 68%) without overt vascular risk factors and 30 demographically-matched healthy controls were recruited prospectively. Cerebral white matter hyperintensities volume was determined by T1-weighted magnetic resonance imaging with CUBE-fluid-attenuated-inversion-recovery sequences. Central systolic blood pressure, carotid-femoral pulse wave velocity, and carotid augmentation index were measured by applanation tonometry...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28837799/essential-role-of-interleukin-12-in-angiogenesis-in-type-2-diabetes
#12
Maha Ali, Vishal Mali, Samuel Haddox, Soad M AbdelGhany, Sahar E M El-Deek, Atif Abulfadl, Khalid Matrougui, Souad Belmadani
Recently interleukin-12 (IL-12) emerged as a critical player in type 2 diabetes complications. We previously reported that ischemia-induced angiogenesis is compromised in type 2 diabetic mice. In this study, we determined that IL-12 disruption rescued angiogenesis and arteriogenesis in type 2 diabetic mice. To induce type 2 diabetes, Wild type (WT); p40IL-12(-/-) (p40-/-) and p35IL-12(-/-) (p35-/-) mice were fed high-fat diet (HFD) for 12 weeks. Body weight, glucose test tolerance, and insulin test tolerance were assessed...
August 21, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28819361/unilateral-headache-status-after-intra-aortic-balloon-pump-placement
#13
Garret M Weber, Alan L Gass, Shalvi B Parikh
INTRODUCTION: Intra-aortic balloon pump (IABP) counterpulsation is a catheter-based treatment for coronary artery disease and decompensated heart failure to increase coronary blood flow and improve cardiac output. IABP is generally well tolerated, and complications are usually related to peripheral vasculature or red blood cell and platelet consumption. The usual insertion site via femoral artery renders the patient bedbound. Recently, axillary artery has been used in patients with atherosclerotic peripheral vascular disease and documented small arteries or in those awaiting transplant to ensure ambulation and prevent deconditioning...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28819006/increased-tissue-oxygenation-explains-the-attenuation-of-hyperaemia-upon-repetitive-pneumatic-compression-of-the-lower-leg
#14
Alessandro Messere, Gianluca Ceravolo, Walter Franco, Daniela Maffiodo, Carlo Ferraresi, Silvestro Roatta
Aim The rapid hyperaemia evoked by muscle compression is short-lived and was recently shown to undergo a rapid decrease even in spite of continuing mechanical stimulation. The present study aims at investigating the mechanisms underlying this attenuation which include local metabolic mechanisms, desensitization of mechano-sensitive pathways, and reduced efficacy of the muscle pump. Methods In 10 healthy subjects short sequences of mechanical compressions (n=3-6; 150 mmHg) of the lower leg were delivered at different inter-stimulus intervals (ranging from 20 to 160 s) through a customized pneumatic device...
August 17, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28810961/resuscitation-of-hypotensive-traumatic-brain-injured-animals-with-spray-dried-plasma-does-not-adversely-alter-physiology-and-improves-blood-brain-barrier-function
#15
Steven McDaniel, Stephanie Golla, Anthony N Moore, Joe DaCorta, Arthur Bode, Shibani Pati, Pramod K Dash, Jing Zhao
INTRODUCTION: According to the Defense and Veterans Brain Injury Center and the Armed Forces Health Surveillance Center, the number of soldiers who have sustained a traumatic brain injury (TBI) has risen dramatically over the past decade. Studies have shown that brain damage can be exacerbated if blood loss occurs (often occurring in polytrauma). As blood supply is critical for brain function and survival, TBI patients must be properly resuscitated to maintain blood volume, blood pressure, and cerebral perfusion...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28805949/the-reversible-p2y12-antagonist-act-246475-causes-significantly-less-blood-loss-than-ticagrelor-at-equivalent-antithrombotic-efficacy-in-rat
#16
Markus Rey, Markus Kramberg, Patrick Hess, Keith Morrison, Roland Ernst, Franck Haag, Edgar Weber, Martine Clozel, Martine Baumann, Eva Caroff, Francis Hubler, Markus A Riederer, Beat Steiner
The P2Y12 receptor is a validated target for prevention of major adverse cardiovascular events in patients with acute coronary syndrome. The aim of this study was to compare two direct-acting, reversible P2Y12 antagonists, ACT-246475 and ticagrelor, in a rat thrombosis model by simultaneous quantification of their antithrombotic efficacy and surgery-induced blood loss. Blood flow velocity was assessed in the carotid artery after FeCl3 -induced thrombus formation using a Doppler flow probe. At the same time, blood loss after surgical wounding of the spleen was quantified...
October 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28763908/-effects-of-flow-through-descending-branch-of-lateral-circumflex-femoral-artery-flap-on-repairing-high-voltage-electrical-burn-wounds-of-wrist-of-patients
#17
Y M Shen, X Chen, C Zhang, C Wang, F J Qin, C X Ma, X H Hu
Objective: To investigate the effects of flow-through descending branch of lateral circumflex femoral artery flap on repairing high-voltage electrical burn wounds of wrist of patients. Methods: From January 2014 to June 2016, 5 patients with high-voltage electrical burn of unilateral wrist were hospitalized in our burn ward, with extensive necrosis of skin soft tissue of burn wrist. Five patients were transferred to our burn ward 6 to 12 days post injury after undergoing emergency dermotomy of wrist to reduce tension in other hospitals...
July 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28748354/pressure-directed-embolization-of-hepatic-arteries-in-a-porcine-model-using-a-temporary-occlusion-balloon-microcatheter-proof-of-concept
#18
Steven C Rose, Gregory D Halstead, Kazim H Narsinh
PURPOSE: The purpose of this project was to test the hypothesis that temporary hepatic artery balloon occlusion would favorably alter the distribution of particle emboli within the targeted and nontargeted downstream vascular compartments. MATERIALS AND METHODS: Five Yorkshire pigs underwent transfemoral placement of balloon microcatheters into selected segmental hepatic arteries. A collection catheter was surgically introduced into a downstream hepatic artery branch...
July 26, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28727031/mammary-nutrient-uptake-in-multiparous-sows-fed-supplementary-arginine-during-gestation-and-lactation
#19
U Krogh, N Oksbjerg, A C Storm, T Feyera, P K Theil
Arginine is the precursor for the synthesis of nitric oxide and may increase mammary plasma flow (MPF), which may in turn increase mammary nutrient uptake. Quantifying mammary nutrient uptake improves our understanding of mammary nutrient metabolism and may potentially allow identification of limiting nutrients for colostrum and milk production. Thus, the objectives of the present study were 1) to study the impact of 25 g/d of crystalline Arg (ARG) on MPF and uptake of nutrients by the mammary glands compared with an isonitrogenous supply of Ala (51 g/d; control [CON]) fed to a total of 8 sows from d 30 of gestation until weaning on d 28 of lactation and 2) to quantify mammary nutrient uptake in late gestation and in early and at peak lactation...
June 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28711487/aucubin-promotes-angiogenesis-via-estrogen-receptor-beta-in-a-mouse-model-of-hindlimb-ischemia
#20
Lu Chen, Yue Yang, Lusha Zhang, Chunxiao Li, Joel Wake Coffie, Xiao Geng, Lizhen Qiu, Xingyu You, Zhirui Fang, Min Song, Xiumei Gao, Hong Wang
Aucubin (AU) is an iridoid glycoside that has been shown to display estrogenic properties and has various pharmacological effects. Herein, we described the angiogenic properties of AU. In the study, hindlimb ischemia was induced by ligation of femoral artery on the right leg of ovariectomized mice. AU treatment significantly accelerated perfusion recovery and reduced tissue injury in mice muscle. Quantification of CD31-positive vessels in hindlimb muscles provided evidences that AU promoted angiogenesis in peripheral ischemia...
September 2017: Journal of Steroid Biochemistry and Molecular Biology
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