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https://www.readbyqxmd.com/read/29458231/perioperative-complications-of-transanal-pull-through-surgery-for-hirschsprung-s-disease
#1
Mikko Pakarinen
Transanal pull-through is currently one of the most commonly used operation to treat Hirschsprung's disease (HD) worldwide. It has undergone some technical modifications during the last decades and still contains variable surgical practices. As high quality comparative studies between different surgical approaches are missing, debate over the optimal operation for HD still continues. Transanal pull-through is associated with multiple potential complications, which may result in permanently impaired functional outcome, life-long morbidity, and significant social restrictions...
February 19, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29458213/selective-targeting-and-degradation-of-doxorubicin-loaded-folate-functionalized-dna-nanocages
#2
Sofia Raniolo, Giulia Vindigni, Alessio Ottaviani, Valeria Unida, Federico Iacovelli, Antonio Manetto, Mariangela Figini, Lorenzo Stella, Alessandro Desideri, Silvia Biocca
Selective targeting is a crucial property of nanocarriers used for drug delivery in cancer therapy. We generated biotinylated octahedral DNA nanocages functionalized with folic acid through bio-orthogonal conjugation chemistry. Molecular modelling indicated that a distance of about 2.5 nm between folic acid and DNA nanocage avoids steric hindrance with the folate receptor. HeLa cells, a folate receptor positive tumour cell line, internalize folate-DNA nanocages with efficiency greater than 40 times compared to cells not expressing the folate receptors...
February 16, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29458209/dermal-anti-oxidant-anti-inflammatory-and-anti-aging-effects-of-compritol-ato-based-resveratrol-colloidal-carriers-prepared-using-mixed-surfactants
#3
Haidy Abbas, Rabab Kamel, Nesrine El-Sayed
In this study, Compritol ATO-based Resveratrol colloidal carriers (CCCs) were prepared. In most formulae, the use of a binary-mixture of surfactants improved the physicochemical properties. CCC6 (containing P407/P188 as bi-surfactants) attained the highest drug loading, release efficiency during 24 hr and occlusive effect for 48 hr; in addition to, a uniform particle size distribution within the desired range. In-vivo studies were done based on the analysis of anti-oxidant markers [catalase (CAT), reduced glutathione (GSH) and superoxide dismutase (SOD)], anti-inflammatory markers [interleukin 6 (IL-6), interleukin 8 (IL-8) and rat Nuclear factor-kappa B (NF-κB)] and anti-wrinkling markers [matrix metalloproteinase (MMP-1) and Granulocyte-macrophage colony-stimulating factor (GM-CSF)], after UVB-irradiation...
February 16, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29458172/modelling-human-myoblasts-survival-upon-xenotransplantation-into-immunodeficient-mouse-muscle
#4
Christophe Praud, Karine Vauchez, Pascal Zongo, Jean-Thomas Vilquin
Cell transplantation has been challenged in several clinical indications of genetic or acquired muscular diseases, but therapeutic success were mitigated. To understand and improve the yields of tissue regeneration, we aimed at modelling the fate of CD56-positive human myoblasts after transplantation. Using immunodeficient severe combined immunodeficiency (SCID) mice as recipients, we assessed the survival, integration and satellite cell niche occupancy of human myoblasts by a triple immunohistochemical labelling of laminin, dystrophin and human lamin A/C...
February 16, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29458159/strawberry-extracts-efficiently-counteract-inflammatory-stress-induced-by-the-endotoxin-lipopolysaccharide-in-human-dermal-fibroblast
#5
Massimiliano Gasparrini, Francesca Giampieri, Tamara Y Forbes-Hernandez, Sadia Afrin, Danila Cianciosi, Patricia Reboredo-Rodriguez, Alfonso Varela-Lopez, JiaoJiao Zhang, Josè L Quiles, Bruno Mezzetti, Stefano Bompadre, Maurizio Battino
A protracted pro-inflammatory state is the common denominator in the development, progression and complication of the common chronic diseases. Dietary antioxidants represent an efficient tool to counteract this inflammatory state. The aim of the present work was to evaluate the effects of strawberry extracts on inflammation evoked by E. Coli lipopolysaccharide in Human Dermal Fibroblast, by measuring reactive oxygen species production, apoptosis rate, antioxidant enzymes activity, mitochondria functionality and also investigating the molecular pathway involved in inflammatory and antioxidant response...
February 16, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29458131/inhibition-of-hepatitis-b-virus-replication-via-hbv-dna-cleavage-by-cas9-from-staphylococcus-aureus
#6
Yu Liu, Miaoxian Zhao, Mingxing Gong, Ying Xu, Cantao Xie, Haohui Deng, Xueying Li, Hongkai Wu, Zhanhui Wang
Chronic hepatitis B virus (HBV) infection is difficult to cure due to the presence of covalently closed circular DNA (cccDNA). Accumulating evidence indicates that the CRISPR/Cas9 system effectively disrupts HBV genome, including cccDNA, in vitro and in vivo. However, efficient delivery of CRISPR/Cas9 system to the liver or hepatocytes using an adeno-associated virus (AAV) vector remains challenging due to the large size of Cas9 from Streptococcus pyogenes (Sp). The recently identified Cas9 protein from Staphylococcus aureus (Sa) is smaller than SpCas9 and thus is able to be packaged into the AAV vector...
February 16, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29458126/structural-and-mechanistic-analysis-of-the-choline-sulfatase-from-sinorhizobium-melliloti-a-class-i-sulfatase-specific-for-an-alkyl-sulfate-ester
#7
Bert van Loo, Markus Schober, Eugene Valkov, Magdalena Heberlein, Erich Bornberg-Bauer, Kurt Faber, Marko Hyvönen, Florian Hollfelder
Hydrolysis of organic sulfate esters proceeds by two distinct mechanisms, water attacking at either sulfur (S-O bond cleavage) or carbon (C-O bond cleavage). In primary and secondary alkyl sulfates attack at carbon is favored, whereas in aromatic sulfates and sulfated sugars attack at sulfur is preferred. This mechanistic distinction is mirrored in the classification of enzymes that catalyze sulfate ester hydrolysis: arylsulfatases catalyze S-O cleavage in sulfate sugars and arylsulfates and alkyl sulfatases break the C-O bond of alkyl sulfates...
February 16, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29458106/combi-metal-organic-framework-combi-mof-of-%C3%AE-amylase-and-glucoamylase-for-one-pot-starch-hydrolysis
#8
Manish Salgaonkar, Shamraja S Nadar, Virendra K Rathod
The multi-enzyme biocatalyst allows to run in vitro multi-step cascade reactions in a single pot. An efficient combi-metal organic frameworks (combi-MOF) of α-amylase and glucoamylase for one pot starch hydrolysis was constructed by mixing zinc acetate and 2‑methylimmidazole with enzyme mixture in one pot under biocompatible conditions. The prepared combi-MOF was characterized and analyzed by powder X-ray diffraction (PXRD), Fourier transform infrared (FT-IR), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM)...
February 16, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29458102/%C3%AE-irradiated-chitosan-based-injectable-hydrogels-for-controlled-release-of-drug-montelukast-sodium
#9
Sadaf Hafeez, Atif Islam, Nafisa Gull, Abbas Ali, Shahzad Maqsood Khan, Saba Zia, Kalsoom Anwar, Saba Urooge Khan, Tahir Jamil
Novel pH-sensitive γ-irradiated low molecular weight chitosan (CS) (pre-irradiated) and poly (vinyl alcohol) (PVA) blended injectable hydrogels, crosslinked with varying concentrations of glycerol, were fabricated for drug delivery application. The effect of low molecular weight irradiated CS on controlled drug release was evaluated to address the problem of higher viscosity and lower solubility of high molecular weight CS. The FTIR spectra of hydrogels depicted the presence of all the incorporated functional groups and the developed interactions (physical and chemical)...
February 16, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29458099/using-near-infrared-spectroscopy-to-predict-the-lignin-content-and-monosaccharide-compositions-of-pinus-radiata-wood-cell-walls
#10
Leona M Fahey, Michél K Nieuwoudt, Philip J Harris
Near infrared (NIR) spectroscopy coupled with partial least squares (PLS-1) regression was used to predict the lignin contents and monosaccharide compositions of milled wood of Pinus radiata. The effects of particle size and moisture content were investigated by collecting NIR spectra of four sample types: large (<0.422 mm) and small (<0.178 mm) particles, in both ambient and dry conditions. PLS-1 models were constructed using mixtures of compression wood (CW) and opposite wood (OW) that provided a linear range of cell-wall compositions...
February 16, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29458093/protective-efficacy-of-mucuna-pruriens-l-seed-meal-enriched-diet-on-growth-performance-innate-immunity-and-disease-resistance-in-oreochromis-mossambicus-against-aeromonas-hydrophila
#11
Mohamed Saiyad Musthafa, Syed Mohideen Asgari, Amitha Kurian, Elumalai Preetham, Abdul Rahman Jawahar Ali, Bilal Ahmad Paray, Mohammad K Al-Sadoon
The impact of Mucuna pruriens (L.) seed meal diet on growth performance, innate immune response, and disease resistance in Oreochromis mossambicus against Aeromonas hydrophila is reported for the first time. Infected O. mossambicus was fed with 2 g kg-1 , 4 g kg-1 , and 6 g kg-1 of M. pruriens seed meal diets significantly increased initial body weight (IBW) and final body weight (FBW) over control, for a period of 4 weeks. At 4 g kg-1 and 6 g kg-1 the enriched diet significantly (P < 0.05) enhanced the survival rate, weight gain (WG), protein efficiency ratio (PER), specific growth rate (SGR), feed conversion ratio (FCR), and feed efficiency (FE) when compared to the control; besides, from weeks 2-4 these diets significantly (P < 0...
February 16, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29458085/the-effect-of-surface-charge-and-ph-on-the-physiological-behaviour-of-cobalt-copper-manganese-antimony-zinc-and-titanium-oxide-nanoparticles-in-vitro
#12
Tiina Titma
The precise knowledge on various interactions of metal nanoparticles (NP) in a living organism is scarce. It is expected that metals can bind to nucleic acids, peptides and proteins (e.g. enzymes), and modify the functioning of vital cellular compartments after entering the organism. The predictive factors for quantitative nanostructure-activity relationship (QNAR) analysis could enhance efficient and harmless usage of nanoparticles (NPs) in the industry as well in the medicine. The studies value the composition of the NP corona determined by time, temperature and source of protein which has been found to implicate the physiological behaviour of NPs...
February 16, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29458022/generation-of-anti-oligosaccharide-antibodies-that-recognize-mammalian-glycoproteins-by-immunization-with-a-novel-artificial-glycosphingolipid
#13
Tetsuya Okuda, Asami Fukui
Here we report a new method for the efficient generation of antibodies that recognize the fine structures of oligosaccharides on glycoproteins. We found a newly designed artificial glycosphingolipid carrying a very long chain fatty acid to be a strong immunogen in mice, with the serum of immunized mice containing antibodies recognizing the oligosaccharide structure of the immunogen. First, we found that conjugation of a simple ceramide analogue to target oligosaccharides could enhance the immunogenicity of these oligosaccharides in these immunized mice...
February 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29457981/reversible-surface-engineering-via-nitrone-mediated-radical-coupling
#14
Joachim Laun, Wouter Marchal, Vanessa Trouillet, Alexander Welle, An T Hardy, Marlies K Van Bael, Christopher Barner-Kowollik, Tanja Junkers
Efficient and simple polymer conjugation reactions are critical for introducing functionalities on surfaces. For polymer surface grafting, post polymerization modifications are often required, which can impose a significant synthetic hurdle. Here, we report two strategies that allow for reversible surface engineering via nitrone-mediated radical coupling (NMRC). Macroradicals stemming from activation of polymers generated by copper-mediated radical polymerization are grafted via radical trapping with a surface-immobilized nitrone or a solution-borne nitrone...
February 19, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29457957/synergistic-effect-of-entomopathogenic-fungus-fusarium-oxysporum-extract-in-combination-with-temephos-against-three-major-mosquito-vectors
#15
Perumal Vivekanandhan, Sengodan Karthi, Muthugounder S Shivakumar, Giovanni Benelli
Mosquito control using chemical insecticides is facing a major challenge due to development of insecticide resistance. Improving the efficiency of existing insecticides using synergistic secondary metabolites of biological origin is increasingly being researched. Herein, we evaluated the toxicity of Fusarium oxysporum extract alone and in binary combinations with temephos, on larvae and pupae of Anopheles stephensi, Aedes aegypti and Culex quinquefaciatus. F. oxysporum extract was characterized using TLC, FT-IR and GC-MS...
February 19, 2018: Pathogens and Global Health
https://www.readbyqxmd.com/read/29457925/controlled-release-of-mitomycin-c-from-phemah-cu-ii-cryogel-membranes
#16
Monireh Bakhshpour, Handan Yavuz, Adil Denizli
Molecular imprinting technique was used for the preparation of antibiotic and anti-neoplastic chemotherapy drug (mitomycin C) imprinted cryogel membranes (MMC-ICM). The membranes were synthezied by using metal ion coordination interactions with N-methacryloyl-(l)-histidine methyl ester (MAH) functional monomer and template molecules (i.e. MMC). The 2-hydroxyethyl methacrylate (HEMA) monomer and methylene bisacrylamide (MBAAm) crosslinker were used for the preparation of mitomycin C imprinted cryogel membranes by radical suspension polymerization technique...
February 19, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29457910/mechanistic-analysis-of-ion-association-between-dendrigraft-poly-l-lysine-and-8-anilino-1-naphthalenesulfonate-at-liquid-liquid-interfaces
#17
Hirohisa Nagatani, Masataka Fujisawa, Hisanori Imura
Molecular association between biocompatible dendritic polymers, dendrigraft poly-L-lysines (DGLs), and an anionic fluorescent probe, 8-anilino-1-naphthalenesulfonate (ANS- ), was studied at the polarized water|1,2-dichloroethane (DCE) interface. The fluorescence intensity of ANS measured in aqueous solution was enhanced by the coexistence of DGL over a wide pH range (2 < pH < 10), where ANS and DGL exist as a monoanionic form and polycation, respectively. The voltammetric responses indicated that the positively charged DGL was adsorbed at the water|DCE interface, while ANS- was transferred across the interface accompanied by the adsorption process...
February 19, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29457905/computational-investigation-on-the-influence-of-halogen-atoms-on-the-photophysical-properties-of-tetraphenylporphyrin-and-its-zinc-ii-complexes
#18
Bruna Clara De Simone, Gloria Mazzone, Nino Russo, Emilia Sicilia, Marirosa Toscano
How the tetraphenylporphyrin (TPP) and its zinc (II) complex (ZnTPP) photophysical properties (adsorption energies, singlet-triplet energy gap and spin orbit coupling contributions) can change due to the presence of an increasing number of heavy atoms in their molecular structures has been investigated by means of density functional theory and its time dependent formulation. Results show as the increase of the atomic mass of the substituted halogen strongly enhances the spin-orbit coupling values allowing a more efficient singlet-triplet intersystem crossing...
February 19, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29457902/multicolor-luminescence-switching-and-controllable-thermally-activated-delayed-fluorescence-turn-on-turn-off-in-carbazole-quinoxaline-carbazole-triads
#19
Ramin Pashazadeh, Piotr Henryk Pander, Algirdas Lazauskas, Fernando B Dias, Juozas Vidas Grazulevicius
In this work we report a series of thermally activated delayed fluorescence (TADF) molecules with mechanochromic luminescence (MCL) properties and reversible TADF turn on/off properties in solid state that are induced by the transition between amorphous and crystalline states. Additionally, multicolor altering through external stimulus is demonstrated. All the studied compounds exhibited recovery of the initial states associated with narrower emission spectra. TADF OLEDs fabricated by solution processing rendered high external quantum efficiency up to 10...
February 19, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29457900/three-dimensional-structures-based-on-the-fusion-of-chrysene-and-spirobifluorene-chromophores-for-the-development-of-blue-oleds
#20
Hayoon Lee, Hyocheol Jung, Seokwoo Kang, Jin Hyuck Heo, Sang Hyuk Im, Jongwook Park
A new deep-blue chromophore containing a three-dimensionally (3D) shaped CS core composed of fused chrysene and spirofluorene units is synthesized. A pair of m-terphenyl (TP) units is also substituted onto the CS core, at two different sets of positions to form two additional compounds: CS-TPTP and TP-CS-TP. The TP-CS-TP compound showed the highest efficiency with an external quantum efficiency (EQE) of 3.05%, and Commission Internationale de L'Eclairage coordinates (CIE) of (0.148, 0.098) corresponding to the emission of blue light...
February 19, 2018: Journal of Organic Chemistry
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