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https://www.readbyqxmd.com/read/28823118/epidemiologic-characteristics-of-scrub-typhus-in-jeju-island-korea
#1
Sung Uk Lee
Purpose: Scrub typhus is the most common febrile disease in Autumn season. Jeju Island is the largest island in South Korea and has a distinctive oceanic climate. This study aimed to identify epidemiological characteristics of scrub typhus in Jeju. Methods: From January 2011 to December 2016, total 446 patients were diagnosed with scrub typhus in Jeju. Patient's personal and environmental factors that may relate to scrub typhus had been investigated and retrospectively analyzed...
August 18, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28823104/novel-polymeric-composites-based-on-carboxymethyl-chitosan-and-poly-acrylic-acid-in-vitro-and-in-vivo-evaluation
#2
Qurat-Ul-Ain Sharif, Muhammad Sohail, Mahmood Ahmad, Muhammad Usman Minhas, Shahzeb Khan, Samiullah Khan, Mubeen Kousar
The purpose of the study was to develop a novel, efficient, stable, chemically crosslinked polymeric system that have pH responsive behaviour and can effectively release 5-FU in a controlled manner. Furthermore it can target colonic cancer minimizing the side effects of in vivo chemotherapy via 5-FU. Swelling and drug release studies were performed to evaluate its in vitro release behaviour. Hydrogels were also characterized by FTIR, SEM and DSC. In vitro cytocompatibility and cytotoxicity of the hydrogels were determined by MTT assay using HeLa cells...
August 19, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28823096/sub-chronic-exposure-to-low-concentration-of-dibutyl-phthalate-affects-anthropometric-parameters-and-markers-of-obesity-in-rats
#3
Khalid Abdul Mjaeed, Habib Ur Rehman, Muhammad Shahbaz Yousaf, Hafsa Zaneb, Imtiaz Rabbani, Sajid Khan Tahir, Muhammad Afzal Rashid
Dibutyl phthalate is an important phthalate ester extensively used in various products like plastics, adhesives, inks, pharmaceuticals, lacquers, varnishes, paper coatings, safety glasses, and cosmetics. The exposure of DBP to "one's health" is therefore inevitable. The present study focuses on elucidating the effect of low doses of DBP on anthropometric parameters and markers of obesity in rats in a 13-week study. A total of 48 rats were divided into three treatment groups as mg DBP/kg body weight per day: (a) 0 mg/kg (control), (b) 10 mg/kg (DBP-10), and (c) 50 mg/kg (DBP-50)...
August 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28823093/candida-albicans-staphylococcus-aureus-dual-species-biofilm-as-a-target-for-the-combination-of-essential-oils-and-fluconazole-or-mupirocin
#4
Aleksandra Budzyńska, Sylwia Różalska, Beata Sadowska, Barbara Różalska
The effectiveness of essential oils (EOs), fluconazole (FLU) and mupirocin (MUP) used alone or in combination against mono-species and mixed Candida albicans/Staphylococcus aureus biofilms was examined. An experimentally established dual-species biofilm model, verified by fluorescence microscopy and viable cell counting, was used. Selected commercial EOs were tested: geranium, citronella and clove oils, which have been chemically characterized and found to differ in the content of the main components (qualitative and quantitative)...
August 19, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28823086/an-efficient-fluorescence-turn-on-chemosensor-comprising-of-coumarin-and-rhodamine-moieties-for-al-3-and-hg-2
#5
Samik Acharyya, Saswati Gharami, Lakshman Patra, Tapan Kumar Mondal
A potent fluorescence 'turn-on' receptor (HL) based on rhodamine and coumarin moieties for the detection of Hg(2+) and Al(3+) is synthesized by condensation of rhodamine 6G hydrazide and 4-hydroxy-3-acetylcoumarin. In presence of Al(3+) and/or Hg(2+) the receptor (HL) exhibits deep pink colouration and a sharp band at 528 nm is appeared in UV-vis titration. Upon gradual addition of Al(3+) and/or Hg(2+) to the solution of HL significant enhancement of fluorescence intensity is observed at 564 nm in MeCN:H2O (1:5, v/v) medium...
August 19, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28823071/accelerating-the-integration-of-distributed-water-solutions-a-conceptual-financing-model-from-the-electricity-sector
#6
Kimberly J Quesnel, Newsha K Ajami, Noemi Wyss
Modern challenges require new approaches to urban water management. One solution in the portfolio of potential strategies is the integration of distributed water infrastructure, practices, and technologies into existing systems. However, many practical barriers have prevented the widespread adoption of these systems in the US. The objective of this paper is to address these challenges by developing a conceptual model encompassing regulatory, financial, and governance components that can be used to incorporate new distributed water solutions into our current network...
August 19, 2017: Environmental Management
https://www.readbyqxmd.com/read/28823025/nanomedicine-associated-with-photodynamic-therapy-for-glioblastoma-treatment
#7
REVIEW
Leonardo B de Paula, Fernando L Primo, Antonio C Tedesco
Glioblastoma, also known as glioblastoma multiforme (GBM), is the most recurrent and malignant astrocytic glioma found in adults. Biologically, GBMs are highly aggressive tumors that often show diffuse infiltration of the brain parenchyma, making complete surgical resection difficult. GBM is not curable with surgery alone because tumor cells typically invade the surrounding brain, rendering complete resection unsafe. Consequently, present-day therapy for malignant glioma remains a great challenge. The location of the invasive tumor cells presents several barriers to therapeutic delivery...
August 19, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28822953/xylanase-from-acinetobacter-pittii-mask-25-and-developed-magnetic-cross-linked-xylanase-aggregate-produce-predominantly-xylopentose-and-xylohexose-from-agro-biomass
#8
Anjali Purohit, Shushil Kumar Rai, Manisha Chownk, Rajender Singh Sangwan, Sudesh Kumar Yadav
Most of the chemical and biochemical processes used for the de-polymerization of structural polymers of lignocellulosic biomass are environment unfriendly and costly. Here an efficient process based on xylanase, produced by Acinetobacter pittii MASK25 (MTCC 25132), hydrolysis of only physically treated rice straw and corn cob has been developed for the production of xylooligosaccharides. Bacterial strain isolated from soil was found to produce maximum xylanase at 30°C and pH 7. While the optimum temperature and pH of xylanase were characterized as 40°C and 5...
August 9, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28822951/effect-of-deflocculation-on-photo-induced-thin-layer-titanium-dioxide-disintegration-of-dairy-waste-activated-sludge-for-cost-and-energy-efficient-methane-production
#9
V Godvin Sharmila, P Dhanalakshmi, J Rajesh Banu, S Kavitha, M Gunasekaran
In the present study, the deflocculated sludge was disintegrated through thin layer immobilized titanium dioxide (TiO2) as photocatalyst under solar irradiation. The deflocculation of sludge was carried out by 0.05g/g SS of sodium citrate aiming to facilitate more surface area for subsequent TiO2 mediated disintegration. The proposed mode of disintegration was investigated by varying TiO2 dosage, pH and time. The maximum COD solubilization of 18.4% was obtained in the optimum 0.4g/L of TiO2 dosage with 5.5 pH and exposure time of 40min...
August 9, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28822950/enhancement-of-organic-matter-degradation-and-methane-gas-production-of-anaerobic-granular-sludge-by-degasification-of-dissolved-hydrogen-gas
#10
Hisashi Satoh, Wasala M K R T W Bandara, Manabu Sasakawa, Yoshihito Nakahara, Masahiro Takahashi, Satoshi Okabe
A hollow fiber degassing membrane (DM) was applied to enhance organic matter degradation and methane gas production of anaerobic granular sludge process by reducing the dissolved hydrogen gas (D-H2) concentration in the liquid phase. DM was installed in the bench-scale anaerobic granular sludge reactors and D-H2 was removed through DM using a vacuum pump. Degasification improved the organic matter degradation efficiency to 79% while the efficiency was 62% without degasification at 12,000mgL(-1) of the influent T-COD concentration...
August 9, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28822948/bacterial-and-archaeal-community-distribution-and-stabilization-of-anaerobic-sludge-in-a-strengthen-circulation-anaerobic-sca-reactor-for-municipal-wastewater-treatment
#11
Bo Yang, Hui Xu, Junfeng Wang, Xinshan Song, Yuhui Wang, Fang Li, Qing Tian, Chunyan Ma, Daoyuan Wang, Junhong Bai, Wolfgang Sand
In this study, a SCA reactor was employed for municipal wastewater treatment at a mesophilic temperature (30°C) under different hydraulic retention times (HRT) and upflow velocities (Vup) to investigate granule sludge stability and spatial microbial distribution. The stable COD removal efficiency readied at HRT of 15, 12, 9 and 6h, and Vup ranging from 0.6 to 5.9mh(-1). EPS fraction analysis of granule sludge shows that municipal wastewater was mainly attributed to the enrichment influence of polysaccharide and tightly bound-EPS...
August 10, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28822889/metformin-targets-gastric-cancer-stem-cells
#12
Sarah Courtois, Raúl V Durán, Julie Giraud, Elodie Sifré, Julien Izotte, Francis Mégraud, Philippe Lehours, Christine Varon, Emilie Bessède
Gastric cancer is the third leading cause of cancer-related deaths worldwide and has still a poor prognosis. Therefore, new therapeutic strategies are needed: among them, targeting cancer stem cells (CSCs) could offer new opportunities. The aim of our study was to evaluate the anti-tumoural effect of metformin on gastric cancer in vitro and in vivo and especially, to determine whether this molecule could target the gastric CSCs. Metformin effects were evaluated on the proliferation and tumourigenic properties of the gastric CSCs from patient-derived primary tumour xenografts (PDXs) and cancer cell lines (MKN45, AGS and MKN74) in vitro in conventional 2 dimensional (2D) and in 3 dimensional (3D) culture systems, in which only CSCs are able to form tumourspheres and in mouse xenograft models in vivo...
August 17, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28822887/the-changing-diagnostic-pathway-for-lung-cancer-patients-in-shanghai-china
#13
REVIEW
Tao Jiang, Shengxiang Ren, Xuefei Li, Chunxia Su, Caicun Zhou, Mary O'Brien
Accumulating evidence suggest that patients with advanced non-small-cell lung cancer (NSCLC) and specific genomic alterations including epidermal growth factor receptor and microtubule-associated protein-like 4 anaplastic lymphoma kinase could significantly benefit from molecular-targeted therapies compared with chemotherapy. Recently, immunotherapy based on programmed cell death 1 (PD-1) and its ligand (PD-L1) blockade prolong survival in patients with advanced NSCLC, especially in those patients with positive expression of PD-L1 and when used in the first-line setting...
August 17, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28822886/concurrent-spectrometry-of-annihilation-radiation-and-characteristic-gamma-rays-for-activity-assessment-of-selected-positron-emitters
#14
S G Dolley, G F Steyn, T J van Rooyen, F Szelecsényi, Z Kovács, C Vermeulen, N P van der Meulen
A method is described to determine the activity of non-pure positron emitters in a radionuclide production environment by assessing the 511keV annihilation radiation concurrently with selected γ-lines, using a single High-Purity Germanium (HPGe) detector. Liquid sources of (22)Na, (52)Fe, (52m)Mn, (61)Cu, (64)Cu, (65)Zn, (66)Ga, (68)Ga, (82)Rb, (88)Y, (89)Zr and (132)Cs were prepared specifically for this study. Acrylic absorbers surrounding the sources ensured that the emitted β(+)-particles could not escape and annihilate away from the source region...
August 1, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28822878/in-vitro-method-to-evaluate-the-barrier-properties-of-medical-devices-for-cutaneous-use
#15
Antonella Casiraghi, Francesco Ranzini, Umberto M Musazzi, Silvia Franzè, Marisa Meloni, Paola Minghetti
Barrier creams (BC) are marketed as cosmetic products or locally-applied medical devices to protect skin against damages induced by chemical agents or physical insults. However, the determination of the BC effectiveness is still a matter of discussion at both the clinical and the regulatory level. In this context, this work aimed at the development of a reliable, reproducible and easy-to-perform experimental protocol for the evaluation of BC performances. Preliminarily, an in vivo method based on the measurement of trans-epidermal water loss had been matter of investigation and was discarded: it required too much time and was not robust and sensitive enough...
August 16, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28822867/de-novo-assembly-and-characterization-of-seabass-lateolabrax-japonicus-transcriptome-and-expression-of-hepatic-genes-following-different-dietary-phosphorus-calcium-levels
#16
Kang-Le Lu, Zhong-Li Ji, Samad Rahimnejad, Chun-Xiao Zhang, Ling Wang, Kai Song
Fish farming seriously influences the aquatic environment because most dietary phosphorus (P) is excreted in the effluent. To increase the P utilization in fish, molecular techniques should be explored given the remarkable development of these techniques. Thus, to identify the candidate genes related to P utilization and molecular alterations following administration of a P-deficient diet in seabass Lateolabrax japonicus, we assessed the de novo pituitary, gill, intestine, liver, kidney, scales and vertebra transcriptomes, and we compared the expression of hepatic genes with three diets varying in P and Ca levels: diet I (0...
August 9, 2017: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/28822862/testing-the-performance-of-superhydrophobic-aluminum-surfaces
#17
F Javier Montes Ruiz-Cabello, Pablo F Ibáñez-Ibáñez, J Francisco Gómez-Lopera, José Martínez-Aroza, Miguel Cabrerizo-Vílchez, Miguel A Rodríguez-Valverde
The analysis of wetting properties of superhydrophobic surfaces may be a difficult task due to the restless behavior of drops on this type of surfaces and the limitations of goniometry for high contact angles. A method to validate the performance of superhydrophobic surfaces, rather than standard goniometry, is required. In this work, we used bouncing drop dynamics as a useful tool to predict the water repellency of different superhydrophobic surfaces. From bouncing drop experiments conducted over a wide range of superhydrophobic surfaces, we found that those surfaces with a proper roughness degree and homogeneous chemical composition showed higher water-repellency...
August 12, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28822860/phloretin-loaded-fast-dissolving-nanofibers-for-the-locoregional-therapy-of-oral-squamous-cell-carcinoma
#18
Suyeong Nam, Song Yi Lee, Hyun-Jong Cho
Fast dissolving nanofiber (NF) composed of poly(vinyl alcohol) (PVA) and d-α-tocopheryl polyethylene glycol succinate (TPGS) was developed for locoregional delivery of phloretin to oral cancers. PVA/TPGS/phloretin NF with 321nm mean diameter and >90% drug entrapment efficiency was fabricated by an electrospinning method. Transformation of drug from crystalline to amorphous state was identified by solid-state studies. NF structure was changed to nanoparticles after its dispersing in the aqueous medium. PVA/TPGS/phloretin NF exhibited fast wetting property and smaller hydrodynamic size of dispersion, compared with PVA/phloretin NF...
August 12, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28822858/comparison-of-genome-engineering-using-the-crispr-cas9-system-in-c-glabrata-wild-type-and-lig4-strains
#19
Yuke Cen, Bea Timmermans, Ben Souffriau, Johan M Thevelein, Patrick Van Dijck
Candida glabrata is reported as the second most prevalent human opportunistic fungal pathogen in North America and is threatening patients all over the world. Its incidence is rising, while it has developed resistance to the most widely used antifungal drugs, necessitating new approaches based on better insight into the biology of the organism. Despite its close phylogenetic relationship with Saccharomyces cerevisiae, generating precise genomic alterations in this species is problematic. Previously we have shown that deletion of LIG4, which encodes an enzyme involved in Non-Homologous End Joining (NHEJ), strongly enhances the probability of obtaining correctly modified transformants...
August 16, 2017: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/28822848/tetracarboxy-phthalocyanines-from-excited-state-dynamics-to-photodynamic-inactivation-against-bovine-herpesvirus-type-1
#20
Leandro H Z Cocca, Taise M A Oliveira, Fernando Gotardo, Amanda V Teles, Ricardo Menegatti, Jonathas P Siqueira, Cleber R Mendonça, Luiz A M Bataus, Anderson O Ribeiro, Thalita F M Souza, Guilherme R L Souza, Pablo J Gonçalves, Leonardo De Boni
Herein we present the excited state dynamic of zinc and aluminum tetracarboxy-phthalocyanines (ZnPc and AlPc) and its application in the photodynamic inactivation (PDI) of Bovine herpesvirus type 1 (BoHV-1) in vitro. The excited state dynamic provides valuable data to describe the excited state properties of potential optical limiters and/or photosensitizers (PSs), such as: the excited state cross-sections, fluorescence lifetime and triplet state quantum yield. The excited state characterization was performed using three different Z-scan techniques: Single Pulse, White Light Continuum and Pulse Train...
August 12, 2017: Journal of Photochemistry and Photobiology. B, Biology
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