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https://www.readbyqxmd.com/read/28719966/safety-and-complications-of-interventional-endoscopic-ultrasound
#1
Monica Saumoy, Michel Kahaleh
Endoscopic ultrasound (EUS) has become an essential tool for the diagnostic and therapeutic intervention of gastrointestinal diseases. Beyond the drainage of fluid collections, it enables decompression of inaccessible bile and pancreatic ducts, the gallbladder, and the creation of anastomosis within the gastrointestinal tract using fully lumen-apposing stents. This review explored the safety and efficacy of these novel procedures and discussed the training pathway that is necessary to perform them efficiently and safely...
July 19, 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28719947/efficient-liquid-media-for-encystation-of-pathogenic-free-living-amoebae
#2
Hae-Jin Sohn, Heekyoung Kang, Ga-Eun Seo, Jong-Hyun Kim, Suk-Yul Jung, Ho-Joon Shin
Pathogenic Naegleria fowleri, Acanthamoeba castellanii, and Acanthamoeba polyphaga, are distributed worldwide. They are causative agents of primary amoebic meningoencephalitis or acanthamoebic keratitis in humans, respectively. Trophozoites encyst in unfavorable environments, such as exhausted food supply and desiccation. Until recently, the method of N. fowleri encystation used solid non-nutrient agar medium supplemented with heat-inactivated Escherichia coli; however, for the amoebic encystment of Acanthamoeba spp...
June 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28719888/inhibition-of-single-routes-of-intracellular-signaling-is-not-sufficient-to-neutralize-the-biphasic-disturbance-of-a-retinal-endothelial-cell-barrier-induced-by-vegf-a165
#3
Heidrun L Deissler, Gerhard K Lang, Gabriele E Lang
BACKGROUND/AIMS: Hallmark of diabetic macular edema is the enhanced permeability of retinal endothelial cells (REC) induced by vascular endothelial growth factor (VEGF-A165), which acts through activating specific receptors. To improve the predictability of inhibitors' potentials to block harmful effects of VEGF-A165, we investigated if its signaling pathways triggered in REC are redundant. METHODS: Immortalized bovine REC monolayers were treated with inhibitors specific for various protein kinases in combination with VEGF-A165...
July 18, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28719876/photoelectrocatalytic-degradation-of-methylene-blue-using-f-doped-tio2-photoelectrode-under-visible-light-irradiation
#4
Dong Liu, Renwen Tian, Jianqiao Wang, Er Nie, Xianqing Piao, Xin Li, Zhuo Sun
Photoelectrocatalysis (PEC) has attracted great interest due to cost effectiveness and high efficiency in water treatment. In this study, F doped TiO2 (F-TiO2) photoelectrodes with honeycomb like morphology were prepared, and the PEC performance was investigated. F-TiO2 particles that showed enhanced absorption of visible light were synthesized via a sol-gel method. F-TiO2 particles were anchored onto the surface of F-doped SnO2 glass by a screen-printing method to prepare the F-TiO2 photoelectrodes. The PEC performance of the F-TiO2 photoelectrodes was investigated via the degradation of methylene blue (MB) under visible light irradiation...
July 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28719864/in-vivo-magnetic-resonance-imaging-of-pancreatic-tumors-using-iron-oxide-nanoworms-targeted-with-ptr86-peptide
#5
Yasaman Ahmadi, Genady Kostenich, Mor Oron-Herman, Wolfgang Wadsak, Markus Mitterhauser, Arie Orenstein, Siroos Mirzaei, Peter Knoll
To cut the high mortality rate of malignant disease such as pancreatic cancer, development of newly diagnostic probes for early stage detection of tumor lesions is required. Multimodal imaging nanoprobes allowing targeted and real time functional/anatomical imaging of tumors meet the demands. For this purpose, a MRI/optical dual-modality probe based on biodegradable magnetic iron oxide nanoworms has been developed. The cross-linked surface of nanoworms were anchored to fluorescent dyes and to FITC.PTR86; a novel synthetic peptide with high affinity towards somatostatin receptors...
July 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28719852/rapid-gamma-spectrometric-analysis-of-soil-samples-after-radioactive-fallout-using-a-conjugate-view-technique
#6
M Isaksson, M Fahlström, N Ossipova, K Rosén
A method for fast determination of the activity in soil samples by measuring a fresh soil core sample from both ends with an HPGe-detector is proposed. The method was tested by simulations, as well as by measurements on spiked soil samples. Both simulations and measurements showed that the geometrical mean of the count rates when the sample is measured twice, with the bottom and the top end, respectively, facing the detector closely resembles the count rate from a measurement on a homogenized sample. Therefore, an efficiency calibration for homogenized samples could be used even if the activity is highly inhomogeneous in the soil core, as is the case with fresh fallout...
July 15, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28719849/selective-cathodic-microbial-biofilm-retention-allows-a-high-current-to-sulfide-efficiency-in-sulfate-reducing-microbial-electrolysis-cells
#7
Guillermo Pozo, Yang Lu, Sebastien Pongy, Jürg Keller, Pablo Ledezma, Stefano Freguia
Selective microbial retention is of paramount importance for the long-term performance of cathodic sulfate reduction in microbial electrolysis cells (MECs) due to the slow growth rate of autotrophic sulfate-reducing bacteria. In this work, we investigate the biofilm retention and current-to-sulfide conversion efficiency using carbon granules (CG) or multi-wall carbon nanotubes deposited on reticulated vitreous carbon (MWCNT-RVC) as electrode materials. For ~2months, the MECs were operated at sulfate loading rates of 21 to 309gSO4 -S/m(2)/d...
July 12, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/28719840/environmental-and-human-health-challenges-of-industrial-livestock-and-poultry-farming-in-china-and-their-mitigation
#8
REVIEW
Yuanan Hu, Hefa Cheng, Shu Tao
Driven by the growing demand for food products of animal origin, industrial livestock and poultry production has become increasingly popular and is on the track of becoming an important source of environmental pollution in China. Although concentrated animal feeding operations (CAFOs) have higher production efficiency and profitability with less resource consumption compared to the traditional family-based and "free range" farming, they bring significant environmental pollution concerns and pose public health risks...
July 15, 2017: Environment International
https://www.readbyqxmd.com/read/28719763/two-equals-one-two-human-actions-during-social-interaction-are-grouped-as-one-unit-in-working-memory
#9
Xiaowei Ding, Zaifeng Gao, Mowei Shen
Every day, people perceive other people performing interactive actions. Retaining these actions of human agents in working memory (WM) plays a pivotal role in a normal social life. However, whether the semantic knowledge embedded in the interactive actions has a pervasive impact on the storage of the actions in WM remains unknown. In the current study, we investigated two opposing hypotheses: (a) that WM stores the interactions individually (the individual-storage hypothesis) and (b) that WM stores the interactions as chunks (the chunk-storage hypothesis)...
July 1, 2017: Psychological Science
https://www.readbyqxmd.com/read/28719751/determining-the-mechanism-and-efficiency-of-industrial-dye-adsorption-through-facile-structural-control-of-organo-montmorillonite-adsorbents
#10
Peng Huang, Algy Kazlauciunas, Robert Menzel, Long Lin
The structural evolution of cost-effective organo-clays (montmorillonite modified with different loadings of CTAB (cetyltrimethylammonium bromide)) is investigated and linked to the adsorption uptake and mechanism of an important industrial dye (hydrolyzed Remazol Black B). Key organo-clay characteristics, such as the intergallery spacing and the average number of well-stacked layers per clay stack are determined by low-angle X-ray diffraction (XRD), while differential thermo-gravimetric analysis (DTGA) is used to differentiate between surface-bound and intercalated CTAB...
July 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28719749/transformation-of-unsaturated-fatty-acids-esters-to-corresponding-keto-fatty-acids-esters-by-aerobic-oxidation-with-pd-ii-lewis-acid-la-catalyst
#11
Ahmed M Senan, Sicheng Zhang, Miao Zeng, Zhuqi Chen, Guochuan Yin
Utilization of renewable biomass to partly replace the fossil resources in industrial applications has attracted attention due to the limited fossil feedstock with the increased environmental concerns. This work introduced a modified Wacker-type oxidation for transformation of unsaturated fatty acids/esters to the corresponding keto fatty acids/esters, in which Cu2+ cation was replaced with common non-redox metal ions, that is, a novel Pd(II)/Lewis acid (LA) catalyst. It was found that adding non-redox metal ions can effectively promote Pd(II)-catalyzed oxidation of unsaturated fatty acids/esters to the corresponding keto fatty acids/esters, even much better than Cu2+, and the promotional effect is highly dependent on the Lewis acidity of added non-redox metal ions...
July 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28719745/highly-efficient-water-decontamination-by-using-sub-10-nm-feooh-confined-within-millimeter-sized-mesoporous-polystyrene-beads
#12
Xiaolin Zhang, Cheng Cheng, Jieshu Qian, Zhenda Lu, Siyuan Pan, Bing-Cai Pan
Millimeter-sized polymer-based FeOOH nanoparticles (NPs) provide a promising option to overcome the bottlenecks of direct use of NPs in scaled-up water purification, and decreasing the NP size below 10 nm is expected to improve the decontamination efficiency of the polymeric nanocomposites due to the size and surface effect. However, it is still challenging to control the dwelled FeOOH NP sizes to sub-10 nm, mainly due to the wide pore size distribution of the currently available polymeric hosts. Herein, we synthesized mesoporous polystyrene beads (MesoPS) via flash freezing to assemble FeOOH NPs...
July 18, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28719743/machine-learning-on-samdi-mass-spectrometry-signal-to-noise-ratio-improves-peptide-array-designs
#13
Albert Yan Xue, Lindsey C Szymczak, Milan Mrksich, Neda Bagheri
Emerging peptide array technologies are able to profile molecular activities within cell lysates. However, the structural diversity of peptides leads to inherent differences in peptide signal to noise ratios (S/N). These complex effects can lead to potentially unrepresentative signal intensities and can bias subsequent analyses. Within mass spectrometry-based peptide technologies, the relation between a peptide's amino acid sequence and S/N remains largely non-quantitative. To address this challenge, we present a method to quantify and analyze mass spectrometry S/N of two peptide arrays, and we use this analysis to portray quality of data and to design future arrays for SAMDI mass spectrometry...
July 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28719738/an-activator-blocker-pair-provides-a-controllable-on-off-switch-for-a-ketosteroid-isomerase-active-site-mutant
#14
Vandana Lamba, Filip Yabukarski, Daniel Herschlag
Control of enzyme activity is fundamental to biology and represents a long-term goal in bioengineering and precision therapeutics. While several powerful molecular strategies have been developed, limitations remain in their generalizability and dynamic range. We demonstrate a control mechanism via separate small molecules that turn on the enzyme (activator) and turn off the activation (blocker). We show that a pocket created near the active site base of the enzyme ketosteriod isomerase (KSI) allows efficient and saturable base rescue when the enzyme's natural general base is removed...
July 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28719729/synthesis-of-c-glucosylated-octaketide-anthraquinones-in-n-benthamiana-using-a-multispecies-based-biosynthetic-pathway
#15
Johan Andersen-Ranberg, Kenneth Thermann Kongstad, Majse Nafisi, Dan Staerk, Finn Okkels, Uffe Hasbro Mortensen, Birger Lindberg Møller, Rasmus John Normand Frandsen, Rubini Kannangara
Carminic acid is a C-glucosylated octaketide anthraquinone and the main constituent of the natural dye carmine (E120) possessing unique coloring, stability and solubility properties. Despite being used since ancient times, longstanding efforts to elucidate its route of biosynthesis have been unsuccessful. Herein is reported a novel combination of enzymes derived from a plant (Aloe arborescens, Aa), a bacterium (Streptomyces sp R1128, St), and an insect (Dactylopius coccus, Dc) that allows for the biosynthesis of the C-glucosylated anthraquinone, dcII, a precursor for carminic acid...
July 18, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28719728/robust-acenaphthoimidazolylidene-palladacycles-highly-efficient-catalysts-for-the-amination-of-n-heteroaryl-chlorides
#16
Tao Tu, Qinyue Deng, Yang Zhang, Haibo Zhu
A series of robust N-heterocyclic carbene palladacycles have been successfully developed, which exhibited high catalytic activity and selectivity toward the challenging amination of N-heteroaryl chlorides. Diverse primary and secondary amines are fully compatible with our new developed catalytic system. Remarkably, no double amination products could be detected when primary amines were utilized in our catalytic transformation. Furthermore, the protocol has been successfully extended to synthesize Rosiglitazone, a clinical drug for diabetes mellitus, highlighting its potential pharmaceutical feasibility...
July 18, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28719672/the-effects-of-ice-on-methane-hydrate-nucleation-a-microcanonical-molecular-dynamics-study
#17
Zhengcai Zhang, Guang-Jun Guo
Although ice powders are widely used in gas hydrate formation experiments, the effects of ice on hydrate nucleation and what happens in the quasi-liquid layer of ice are still not well understood. Here, we used high-precision constant energy molecular dynamics simulations to study methane hydrate nucleation from vapor-liquid mixtures exposed to the basal, prismatic, and secondary prismatic planes of hexagonal ice (ice Ih). Although no significant difference is observed in hydrate nucleation processes for these different crystal planes, it is found, more interestingly, that methane hydrate can nucleate either on the ice surface heterogeneously or in the bulk solution phase homogeneously...
July 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28719658/optisampletm-open-web-based-application-to-optimize-sampling-strategies-for-active-surveillance-activities-at-the-herd-level-illustrated-using-porcine-respiratory-reproductive-syndrome-prrs
#18
Anna Alba, Robert E Morrison, Ann Cheeran, Albert Rovira, Julio Alvarez, Andres M Perez
Porcine reproductive and respiratory syndrome virus (PRRSv) infection causes a devastating economic impact to the swine industry. Active surveillance is routinely conducted in many swine herds to demonstrate freedom from PRRSv infection. The design of efficient active surveillance sampling schemes is challenging because optimum surveillance strategies may differ depending on infection status, herd structure, management, or resources for conducting sampling. Here, we present an open web-based application, named 'OptisampleTM', designed to optimize herd sampling strategies to substantiate freedom of infection considering also costs of testing...
2017: PloS One
https://www.readbyqxmd.com/read/28719651/link-prediction-on-twitter
#19
Sanda Martinčić-Ipšić, Edvin Močibob, Matjaž Perc
With over 300 million active users, Twitter is among the largest online news and social networking services in existence today. Open access to information on Twitter makes it a valuable source of data for research on social interactions, sentiment analysis, content diffusion, link prediction, and the dynamics behind human collective behaviour in general. Here we use Twitter data to construct co-occurrence language networks based on hashtags and based on all the words in tweets, and we use these networks to study link prediction by means of different methods and evaluation metrics...
2017: PloS One
https://www.readbyqxmd.com/read/28719647/morbidity-outcomes-and-cost-benefit-analysis-of-wildlife-rehabilitation-in-catalonia-spain
#20
Rafael Angel Molina-López, Santi Mañosa, Alex Torres-Riera, Manel Pomarol, Laila Darwich
BACKGROUND: There are few studies of careful examination of wildlife casualties in Wildlife Rehabilitation Centers. These studies are essential for detecting menaces to wild species and providing objective criteria about cost-benefit of treatments in those centers. The release rate is considered the main outcome indicator, but other parameters such as length of stay at the center and a cost-benefit index expressed as number of released animals per euro and day, could be used as reliable estimators of the rehabilitation costs...
2017: PloS One
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