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https://www.readbyqxmd.com/read/28926562/generics-for-the-treatment-of-hepatitis-c-in-monoinfected-and-hiv-coinfected-patients-pros-and-cons
#1
Dario Cattaneo, Alessandro Fossati, Chiara Resnati, Massimo Galli, Cristina Gervasoni
The treatment of hepatitis C virus in monoinfected and HIV-coinfected patients has greatly changed over recent years as a result of the introduction of direct-acting antiviral agents (DAAs), which have revolutionized clinical outcomes and led to sustained virological response rates above 90-95%. The discovery of new molecules and the subsequent competition between pharmaceutical companies, together with the negotiated price policies pursued by many national health systems, have led to a gradual reduction in the cost of DAAs, and expand their use to an increasing number of patients, including those with mild liver damage...
September 19, 2017: AIDS Reviews
https://www.readbyqxmd.com/read/28926344/the-effect-of-severity-of-illness-on-spine-surgery-costs-across-new-york-state-hospitals-an-analysis-of-69-831-cases
#2
I David Kaye, Murillo Adrados, Raj J Karia, Themistocles S Protopsaltis, Joseph A Bosco
STUDY DESIGN: Observational database review. OBJECTIVE: To determine the effect of patient severity of illness (SOI) on the cost of spine surgery among New York state hospitals. SUMMARY OF BACKGROUND DATA: National health care spending has risen at an unsustainable rate with musculoskeletal care, and spine surgery in particular, accounting for a significant portion of this expenditure. In an effort towards cost-containment, health care payers are exploring novel payment models some of which reward cost savings but penalize excessive spending...
September 18, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28923427/minimally-invasive-versus-open-surgery-for-lumbar-synovial-cysts
#3
Pierluigi Vergara, Christopher Yusuf Akhunbay-Fudge, Mark Robert Kotter, Rodney John Charles Laing
OBJECTIVE: Lumbar synovial cysts are relatively infrequent. Historically, these benign lesions have been treated with open excision, sometimes associated with fusion. The aim of this study is to compare Minimally Invasive Surgery (MIS) with Open Surgery (OS) for the treatment of lumbar synovial cysts. METHODS: Retrospective review of patients who underwent minimally invasive or open excision of lumbar synovial cysts. Clinical outcomes, recurrence rate and surgical complications were compared in the 2 groups...
September 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28922907/organ-vouchers-and-barter-markets-saving-lives-reducing-suffering-and-trading-in-human-organs
#4
Mark J Cherry
The essays in this issue of The Journal of Medicine and Philosophy explore an innovative voucher program for encouraging kidney donation. Discussions cluster around a number of central moral and political/theoretical themes: (1) What are the direct and indirect health care costs and benefits of such a voucher system in human organs? (2) Do vouchers lead to more effective and efficient organ procurement and allocation or contribute to greater inequalities and inefficiencies in the transplantation system? (3) Do vouchers contribute to the inappropriate commodification of human body parts? (4) Is there a significant moral difference between such a voucher system and a market in human organs for transplantation? This paper argues that while kidney vouchers constitute a step in the right direction, fuller utilization of market-based incentives, including, but not limited to, barter exchanges (e...
October 1, 2017: Journal of Medicine and Philosophy
https://www.readbyqxmd.com/read/28922519/a-cost-minimisation-analysis-of-olive-oil-versus-hyperoxygenated-fatty-acid-treatment-for-the-prevention-of-pressure-ulcers-in-primary-health-care-a-randomised-controlled-trial
#5
Inmaculada Lupiañez-Pérez, Juan Carlos Morilla-Herrera, Shakira Kaknani-Uttumchanchandani, Yolanda Lupiañez-Perez, Magdalena Cuevas-Fernandez-Gallego, Francisco Martin-Santos, Jorge Caro-Bautista, Jose Miguel Morales-Asencio
Pressure ulcers represent a major current health problem and cause an important economic impact on the health care system. Most studies on the prevention of pressure ulcers have been carried out in hospital contexts, with respect to the use of hyperoxygenated fatty acids, and to date no studies have specifically examined the use of olive oil-based treatments. AIM: To evaluate the cost of using extra virgin olive oil, rather than hyperoxygenated fatty acids, in the prevention of pressure ulcers among persons with impaired mobility and receiving home care...
September 18, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28922137/finite-time-synchronization-of-networks-via-quantized-intermittent-pinning-control
#6
Chen Xu, Xinsong Yang, Jianquan Lu, Jianwen Feng, Fuad E Alsaadi, Tasawar Hayat
This technical correspondence considers finite-time synchronization of dynamical networks by designing aperiodically intermittent pinning controllers with logarithmic quantization. The control scheme can greatly reduce control cost and save both communication channels and bandwidth. By using multiple Lyapunov functions and convex combination techniques, sufficient conditions formulated by a set of linear matrix inequalities are derived to guarantee that all the node systems are synchronized with an isolated trajectory in a finite settling time...
September 18, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28922071/implementing-electronic-data-capture-at-a-well-established-health-and-demographic-surveillance-site-in-rural-northern-malawi
#7
Estelle McLean, Albert Dube, Jacky Saul, Keith Branson, Mabvuto Luhanga, Oddie Mwiba, Fredrick Kalobekamo, Steffen Geis, Amelia C Crampin
This article aims to assess multiple issues of resources, staffing, local opinion, data quality, cost, and security while transitioning to electronic data collection (EDC) at a long-running community research site in northern Malawi. Levels of missing and error fields, delay from data collection to availability, and average number of interviews per day were compared between EDC and paper in a complex, repeated annual household survey. Three focus groups with field and data staff with experience using both methods, and in-depth interviews with participants were carried out...
2017: Global Health Action
https://www.readbyqxmd.com/read/28921446/can-a-novel-icu-data-display-positively-affect-patient-outcomes-and-save-lives
#8
Natalia Olchanski, Mikhail A Dziadzko, Ing C Tiong, Craig E Daniels, Steve G Peters, John C O'Horo, Michelle N Gong
The aim of this study was to quantify the impact of ProCCESs AWARE, Ambient Clinical Analytics, Rochester, MN, a novel acute care electronic medical record interface, on a range of care process and patient health outcome metrics in intensive care units (ICUs). ProCCESs AWARE is a novel acute care EMR interface that contains built-in tools for error prevention, practice surveillance, decision support and reporting. We compared outcomes before and after AWARE implementation using a prospective cohort and a historical control...
September 18, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28921395/analysis-of-integrated-clinical-trial-protocols-in-early-phases-of-medicinal-product-development
#9
Kevin Fruhner, Gunther Hartmann, Thomas Sudhop
PURPOSE: While in the past, most clinical trial applications (CTAs) following non-integrated (standard) protocols were used to investigate one primary objective concerning a (new) drug, nowadays, the use of integrated protocols investigating multiple objectives within the same CTA becomes more and more popular. The aims of the present study were to investigate the usage and the impact of integrated protocols on regulatory activities and to find the motivation for their increasing use...
September 18, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28919794/parenteral-nutrition-including-an-omega-3-fatty-acid-containing-lipid-emulsion-for-intensive-care-patients-in-china-a-pharmacoeconomic-analysis
#10
Yufei Feng, Chao Li, Tian Zhang, Lorenzo Pradelli
BACKGROUND/OBJECTIVES: Parenteral nutrition (PN) incorporating omega-3 fatty-acid-enriched lipid emulsions has been shown to be cost effective in Western populations. A pharmacoeconomic evaluation was performed within the Chinese intensive care unit (ICU) setting. This assessed whether the additional acquisition cost of PN with omega-3 fatty-acid-enriched lipid emulsion (SMOFlipid) vs standard PN was offset by improved clinical outcomes that can reduce subsequent costs. MATERIALS AND METHODS: A pharmacoeconomic discrete event simulation model was developed, based on an update to efficacy data from a previous international meta-analysis, with China-specific clinical and economic input parameters...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28919685/prevalence-of-listeria-monocytogenes-yersinia-enterocolitica-staphylococcusaureus-and-salmonella-enterica-typhimurium-in-meat-and-meat-products-using-multiplex-polymerase-chain-reaction
#11
C Latha, C J Anu, V J Ajaykumar, B Sunil
AIM: The objective of the study was to investigate the occurrence of Listeria monocytogenes, Yersinia enterocolitica, Staphylococcusaureus, and Salmonella enterica Typhimurium in meat and meat products using the multiplex polymerase chain reaction (PCR) method. MATERIALS AND METHODS: The assay combined an enrichment step in tryptic soy broth with yeast extract formulated for the simultaneous growth of target pathogens, DNA isolation and multiplex PCR. A total of 1134 samples including beef (n=349), chicken (n=325), pork (n=310), chevon (n=50), and meat products (n=100) were collected from different parts of Kerala, India...
August 2017: Veterinary World
https://www.readbyqxmd.com/read/28919292/treatment-patterns-health-care-resource-utilization-and-spending-in-medicaid-beneficiaries-initiating-second-generation-long-acting-injectable-agents-versus-oral-atypical-antipsychotics
#12
Dominic Pilon, Neeta Tandon, Marie-Hélène Lafeuille, Rhiannon Kamstra, Bruno Emond, Patrick Lefebvre, Kruti Joshi
PURPOSE: Second-generation long-acting injectable therapies (SGA-LAIs) may reduce health care resource utilization (HRU) and health care costs compared with daily oral atypical antipsychotics (OAAs) in patients with schizophrenia due to reduced dosing frequency, delivery/monitoring by a health care provider, and improved adherence. The aim of the present study was to compare treatment patterns, HRU, and Medicaid spending in patients with schizophrenia initiated on SGA-LAIs (overall and according to agent) versus OAAs...
September 14, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28919225/a-comparative-cost-analysis-of-the-vaccination-program-for-us-bound-refugees
#13
Heesoo Joo, Brian Maskery, Tarissa Mitchell, Andrew Leidner, Alexander Klosovsky, Michelle Weinberg
BACKGROUND: Vaccination Program for US-bound Refugees (VPR) currently provides one or two doses of some age-specific Advisory Committee on Immunization Practices (ACIP)-recommended vaccines to US-bound refugees prior to departure. METHODS: We quantified and compared the full vaccination costs for refugees using two scenarios: (1) the baseline of no VPR and (2) the current situation with VPR. Under the first scenario, refugees would be fully vaccinated after arrival in the United States...
September 14, 2017: Vaccine
https://www.readbyqxmd.com/read/28918341/is-first-trimester-hba1c-useful-in-the-diagnosis-of-gestational-diabetes
#14
David Benaiges, Juana A Flores-Le Roux, Irene Marcelo, Laura Mañé, Marta Rodríguez, Xavier Navarro, Juan J Chillarón, Gemma Llauradó, Lucia Gortazar, Juan Pedro-Botet, Antonio Payà
AIMS: To evaluate the usefulness and efficacy of first-trimester HbA1c in the diagnosis of gestational diabetes (GDM). METHODS: Prospective observational of consecutive pregnant women. All women had a first-trimester HbA1c determination and GDM screening at 24-28weeks of pregnancy using a two-step approach. A ROC curve was drawn to determine the sensitivity and specificity of HbA1c in detecting GDM and a rule-in rule-out diagnostic algorithm was proposed. The cost of the proposed algorithm was calculated...
August 30, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28918078/assessment-of-environmental-impacts-and-operational-costs-of-the-implementation-of-an-innovative-source-separated-urine-treatment
#15
Elorri Igos, Mathilde Besson, Tomás Navarrete Gutiérrez, Ana Barbara Bisinella de Faria, Enrico Benetto, Ligia Barna, Aras Ahmadi, Mathieu Spérandio
Innovative treatment technologies and management methods are necessary to valorise the constituents of wastewater, in particular nutrients from urine (highly concentrated and can have significant impacts related to artificial fertilizer production). The FP7 project, ValuefromUrine, proposed a new two-step process (called VFU) based on struvite precipitation and microbial electrolysis cell (MEC) to recover ammonia, which is further transformed into ammonium sulphate. The environmental and economic impacts of its prospective implementation in the Netherlands were evaluated based on life cycle assessment (LCA) methodology and operational costs...
September 8, 2017: Water Research
https://www.readbyqxmd.com/read/28917963/an-efficient-computational-fluid-particle-dynamics-method-to-predict-deposition-in-a-simplified-approximation-of-the-deep-lung
#16
P G Koullapis, P Hofemeier, J Sznitman, S C Kassinos
High-fidelity simulations of the complete airway tree are still largely beyond current computational capabilities. Towards large-scale simulations of the human lung, the current study introduces a numerical methodology to predict particle deposition in a simplified approximation of the deep lung during a full breathing cycle. The geometrical model employed consists of an idealised bronchial tree that represents generations 10 to 19 of the conducting zone and an heterogeneous acinar model created using a space-filling algorithm...
September 13, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28917019/the-trend-toward-minimally-invasive-complex-abdominal-wall-reconstruction-is-it-worth-it
#17
Igor Belyansky, Adam S Weltz, Udai S Sibia, Justin J Turcotte, Haley Taylor, H Reza Zahiri, T Robert Turner, Adrian Park
BACKGROUND: Open abdominal wall reconstruction (AWR) was previously one of the only methods available to treat complex ventral hernias. We set out to identify the impact of laparoscopy and robotics on our AWR program by performing an economic analysis before and after the institution of minimally invasive AWR. METHODS: We retrospectively reviewed inpatient hospital costs and economic factors for a consecutive series of 104 AWR cases that utilized separation of components technique (57 open, 38 laparoscopic, 9 robotic)...
September 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28916506/blending-face-to-face-and-internet-based-interventions-for-the-treatment-of-mental-disorders-in-adults-systematic-review
#18
Doris Erbe, Hans-Christoph Eichert, Heleen Riper, David Daniel Ebert
BACKGROUND: Many studies have provided evidence for the effectiveness of Internet-based stand-alone interventions for mental disorders. A newer form of intervention combines the strengths of face-to-face (f2f) and Internet approaches (blended interventions). OBJECTIVE: The aim of this review was to provide an overview of (1) the different formats of blended treatments for adults, (2) the stage of treatment in which these are applied, (3) their objective in combining face-to-face and Internet-based approaches, and (4) their effectiveness...
September 15, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28915166/factors-associated-with-hospital-participation-in-centers-for-medicare-and-medicaid-services-accountable-care-organization-programs
#19
Askar S Chukmaitov, David W Harless, Gloria J Bazzoli, Yangyang Deng
BACKGROUND: In 2012, the Centers for Medicare and Medicaid Services (CMS) initiated the Medicare Shared Savings Program (MSSP) and Pioneer Accountable Care Organization (ACO) programs. Organizations in the MSSP model shared cost savings they generated with CMS, and those in the Pioneer program shared both savings and losses. It is largely unknown what hospital and environmental characteristics are associated with the development of CMS ACOs with one- or two-sided risk models. PURPOSE: The aim of this study was to assess the organizational and environmental characteristics associated with hospital participation in the MSSP and Pioneer ACOs...
September 15, 2017: Health Care Management Review
https://www.readbyqxmd.com/read/28914780/public-health-network-structure-and-collaboration-effectiveness-during-the-2015-mers-outbreak-in-south-korea-an-institutional-collective-action-framework
#20
KyungWoo Kim, Simon A Andrew, Kyujin Jung
Following the 2015 Middle East Respiratory Syndrome (MERS) outbreak in South Korea, this research aims to examine the structural effect of public health network explaining collaboration effectiveness, which is defined as joint efforts to improve quality of service provision, cost savings, and coordination. We tested the bonding and bridging effects on collaboration effectiveness during the MERS outbreak response by utilizing an institutional collective action framework. The analysis results of 114 organizations responding during the crisis show a significant association between the bonding effect and the effectiveness of collaboration, as well as a positive association between risk communication in disseminating public health information and the effectiveness of collaboration...
September 15, 2017: International Journal of Environmental Research and Public Health
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