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https://www.readbyqxmd.com/read/29434990/abiraterone-acetate-withdrawal-syndrome-speculations-on-the-underlying-mechanisms
#1
Tomonori Kato, Akira Komiya, Joji Yuasa, Kanya Kaga, Mayuko Kaga, Satoko Kojima, Yukio Naya, Shigeo Isaka
A 72-year-old man initially presented with lumbar and right chest pain, but was later found out to also have an elevated prostate-specific antigen (PSA) level at 2,000.0 ng/ml. Further evaluation disclosed metastatic prostate cancer involving the bones and lymph nodes. The patient was initially treated with combined androgen blockade (CAB) with leuprolide acetate and bicalutamide. After 6 months of CAB, the patient's PSA level began to rise from the nadir (85.1 ng/ml) to 113.3 ng/ml. Bicalutamide was withdrawn in anticipation of anti-androgen withdrawal syndrome and the PSA level declined temporally...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29428925/adjuvant-therapy-yiqiditantongfu-decoction-with-external-diaphragm-pacer-for-chronic-obstructive-pulmonary-disease-patients-with-difficulty-weaning-from-mechanical-ventilation
#2
Cong He, Shan Ren, Quansheng Du, Yong Wang, Hui Liu, Heling Zhao, Limin Shen, Ling Long, Xianlei Wang
Context • Global morbidity from chronic obstructive pulmonary disease (COPD) is high worldwide. Diaphragm pacing (DP) can maintain the natural, negative pressure breathing of COPD patients with diaphragmatic muscle dysfunction. The YiqiDitanTongfu (YDTF) decoction has been used clinically with COPD patients to help them to wean from mechanical ventilation, with their ventilation functions being improved and the success rate of weaning being largely increased. Objective • The study intended to investigate the combined therapeutic effects of external DP and the YDTF decoction for COPD patients who have had difficulty weaning from mechanical ventilation...
February 10, 2018: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29428776/a-planned-complex-suicide-by-self-stabbing-and-vehicular-crash-an-original-case-and-review-of-the-literature
#3
Emilie Christin, Jean Hiquet, Jonathan Fougas, Olivier Dubourg, Sophie Gromb-Monnoyeur
Suicide is a frequent manner of unnatural death, especially from a forensic point of view. Complex suicide is defined as a recourse to more than one potentially lethal mechanism to deliberately induce death. This paper presents a complex suicide with a novel combination of self-killing methods. A 27 year-old man, working as a butcher, was found dead in his crashed car. The facts were initially in favour of an obvious traffic accident until a knife was discovered penetrating the driver's chest, requiring the police who were on the scene to carry out a criminal investigation...
January 31, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29424792/in-depth-characterization-of-the-effects-of-cigarette-smoke-exposure-on-the-acute-trauma-response-and-hemorrhage-in-mice
#4
Clair Hartmann, Michael Gröger, Jan-Philipp Noirhomme, Angelika Scheuerle, Peter Möller, Ulrich Wachter, Markus Huber-Lang, Benedikt Nussbaum, Birgit Jung, Tamara Merz, Oscar McCook, Sandra Kress, Bettina Stahl, Enrico Calzia, Michael Georgieff, Peter Radermacher, Martin Wepler
INTRODUCTION: Hemorrhagic shock accounts for a large amount of trauma-related mortality. The severity of trauma can be further aggravated by an additional blunt chest trauma (TxT), which independently contributes to mortality upon the development of an acute lung injury (ALI). Besides, cigarette smoke (CS) exposure before TxT enhanced posttraumatic inflammation, thereby aggravating ALI. We therefore aimed to characterize the impact of an acute and/or chronic lung injury on organ dysfunction in a murine model of traumatic hemorrhagic shock (HS)...
February 8, 2018: Shock
https://www.readbyqxmd.com/read/29417038/miliary-tuberculosis-with-pulmonary-and-extrapulmonary-component-complicated-with-acute-respiratory-distress-syndrome
#5
Bhupen Barman, Iadarilang Tiewsoh, Kyrshanlang G Lynrah, Baphira Wankhar, Taso Beyong, Neel Kanth Issar
Miliary tuberculosis results from the lymphohematogenous spread of the tubercle bacilli to the vascular beds in the lungs and other organs. Diagnosis is made by clinical judgment and chest X-ray showing miliary mottling of the lung fields. Another imaging study like computed tomography imaging of the lungs and abdomen can also be supportive in diagnosing miliary tuberculosis. We present a case of miliary tuberculosis in an immunocompetent young male with atypical manifestation of a left-sided pleural effusion and a life-threatening complication of acute respiratory distress syndrome during hospital stay which required noninvasive mechanical ventilation and steroids therapy, along with antitubercular medication...
July 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29416360/clinical-characteristics-of-the-first-cases-of-invasive-candidiasis-in-china-due-to-pan-echinocandin-resistant-candida-tropicalis-and-candida-glabrata-isolates-with-delineation-of-their-resistance-mechanisms
#6
Meng Xiao, Xin Fan, Xin Hou, Sharon Ca Chen, He Wang, Fanrong Kong, Zi-Yong Sun, Yun-Zhuo Chu, Ying-Chun Xu
Echinocandin antifungal agents have become the first-line therapy for invasive candidiasis (IC) in many countries. Despite their increasing use, resistance to this class of drug is, overall, still uncommon. Here, we report two patients from the People's Republic of China with IC, one with infection caused by pan-echinocandin-resistant Candida tropicalis and the other by pan-echinocandin-resistant Candida glabrata. We also describe the mechanisms of drug resistance of these isolates. The echinocandin-resistant C...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29415556/patterns-of-use-survival-and-prognostic-factors-in-patients-receiving-home-mechanical-ventilation-in-western-australia-a-single-centre-historical-cohort-study
#7
Geak Poh Tan, Nigel McArdle, Satvinder Singh Dhaliwal, Jane Douglas, Clare Siobhan Rea, Bhajan Singh
Home mechanical ventilation (HMV) is used in a wide range of disorders associated with chronic hypoventilation. We describe the patterns of use, survival and predictors of death in Western Australia. We identified 240 consecutive patients (60% male; mean age 58 years and body mass index 31 kg m-2) referred for HMV between 2005 and 2010. The patients were grouped into four categories: motor neurone disorders (MND; 39%), pulmonary disease (PULM; 25%, mainly chronic obstructive pulmonary disease), non-MND neuromuscular and chest wall disorders (NMCW; 21%) and the obesity hypoventilation syndrome (OHS; 15%)...
January 1, 2018: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29413511/mechanisms-underlying-the-impact-of-exercise-training-in-pulmonary-arterial-hypertension
#8
REVIEW
Rita Nogueira-Ferreira, Daniel Moreira-Gonçalves, Mário Santos, Fábio Trindade, Rita Ferreira, Tiago Henriques-Coelho
Pulmonary arterial hypertension (PAH) is a devastating disease characterized by progressive increases in pulmonary vascular resistance that can ultimately lead to right ventricle failure and death. Common symptoms include shortness of breath, fatigue, dizziness and chest pain, which negatively impact the functional capacity and quality of life. Despite the improvements in disease-targeted therapies, PAH remains incurable and with a high mortality rate, requiring effective therapeutic strategies. Exercise training is an important adjunct non-pharmacological treatment for patients with left heart failure and chronic obstructive pulmonary disease...
January 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29411048/comparison-of-analgesic-interventions-for-traumatic-rib-fractures-a-systematic-review-and-meta-analysis
#9
Jesse Peek, Diederik P J Smeeing, Falco Hietbrink, Roderick M Houwert, Marije Marsman, Mirjam B de Jong
PURPOSE: Many studies report on outcomes of analgesic therapy for (suspected) traumatic rib fractures. However, the literature is inconclusive and diverse regarding the management of pain and its effect on pain relief and associated complications. This systematic review and meta-analysis summarizes and compares reduction of pain for the different treatment modalities and as secondary outcome mortality during hospitalization, length of mechanical ventilation, length of hospital stay, length of intensive care unit stay (ICU) and complications such as respiratory, cardiovascular, and/or analgesia-related complications, for four different types of analgesic therapy: epidural analgesia, intravenous analgesia, paravertebral blocks and intercostal blocks...
February 6, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29406478/the-use-of-chest-computed-tomographic-angiography-in-blunt-trauma-pediatric-population
#10
Rabea Hasadia, Joseph DuBose, Kobi Peleg, Jacob Stephenson, Adi Givon, Boris Kessel
INTRODUCTION: Blunt chest trauma in children is common. Although rare, associated major thoracic vascular injuries (TVIs) are lethal potential sequelae of these mechanisms. The preferred study for definitive diagnosis of TVI in stable patients is computed tomographic angiography imaging of the chest. This imaging modality is, however, associated with high doses of ionizing radiation that represent significant carcinogenic risk for pediatric patients. The aim of the present investigation was to define the incidence of TVI among blunt pediatric trauma patients in an effort to better elucidate the usefulness of computed tomographic angiography use in this population...
February 5, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29402510/pleural-manometry-in-patients-with-pleural-diseases-the-usefulness-in-clinical-practice
#11
REVIEW
Elzbieta M Grabczak, Rafal Krenke, Monika Zielinska-Krawczyk, Richard W Light
Although pleural manometry is a relatively simple medical procedure it is only occasionally used to follow pleural pressure (Ppl) changes during a therapeutic thoracentesis and pneumothorax drainage. As some studies showed that pleural pressure monitoring might be associated with significant advantages, pleural manometry has been increasingly evaluated in the last decade. The major clinical applications of pleural pressure measurements include: the prevention of complications associated with large volume thoracentesis, diagnosis and differentiation between various types of an unexpandable lung and a possible prediction of the efficacy of chest tube drainage in patients with spontaneous pneumothorax...
January 31, 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29397887/ten-year-trends-in-traumatic-injury-mechanisms-and-outcomes-a-trauma-registry-analysis
#12
REVIEW
Zhamak Khorgami, William J Fleischer, Yuen-Jing A Chen, Nasir Mushtaq, Michael S Charles, C Anthony Howard
BACKGROUND: The Oklahoma Trauma Registry (OTR) collects data from all state-licensed acute care hospitals. This study investigates trends and outcomes of trauma in Oklahoma using OTR. METHODS: 107,549 patients (2005-2014) with major severity and one of the following criteria were included: length of hospital stay ≥48 h, dead on arrival or death in the hospital, hospital transfer, ICU admission, or surgery on the head, chest, abdomen, or vascular system. Patient characteristics, mechanisms of injury, and outcomes of trauma were analyzed...
January 31, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29395757/standardized-model-of-porcine-resuscitation-using-a-custom-made-resuscitation-board-results-in-optimal-hemodynamic-management
#13
Jakob Wollborn, Eva Ruetten, Bjoern Schlueter, Joerg Haberstroh, Ulrich Goebel, Martin A Schick
AIM: Standardized modeling of cardiac arrest and cardiopulmonary resuscitation (CPR) is crucial to evaluate new treatment options. Experimental porcine models are ideal, closely mimicking human-like physiology. However, anteroposterior chest diameter differs significantly, being larger in pigs and thus poses a challenge to achieve adequate perfusion pressures and consequently hemodynamics during CPR, which are commonly achieved during human resuscitation. The aim was to prove that standardized resuscitation is feasible and renders adequate hemodynamics and perfusion in pigs, using a specifically designed resuscitation board for a pneumatic chest compression device...
January 22, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29395566/-clinical-and-radiological-characteristics-of-pulmonary-tuberculosis-in-tobacco-smokers
#14
U D Kombila, F B R Mbaye, Y Dia Kane, W Ka, N O Toure Badiane
INTRODUCTION: Tobacco smoke alters lung defense mechanisms against infections and so increases the risk of mycobacterium tuberculosis infection. OBJECTIVE: To determine the particular clinical features of tuberculosis in smokers and identify risk factors. METHODS AND PATIENTS: We conducted a prospective, cross-sectional study over a period of nine months in Dakar, Senegal. The Chi-square test and multiple logistic regression were used to identify differences between smokers and non-smokers and to identify factors associated with clinical outcomes...
January 27, 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29392888/organizing-pneumonia-related-to-electronic-cigarette-use-a-case-report-and-review-of-literature
#15
REVIEW
Mohammad Saud Khan, Faisal Khateeb, Jamal Akhtar, Zubair Khan, Amos Lal, Veronika Kholodovych, Jeffrey Hammersley
BACKGROUND AND OBJECTIVES: Electronic cigarettes (e cigarettes) are battery operated devices that produce aerosol by heating a solution typically made up of nicotine, propylene glycol, glycerin and flavoring agents. The use of e cigarettes has risen dramatically in recent years especially among adolescents and young adults. These devices have been marketed as safer alternatives to tobacco smoking by their manufactures despite lack of adequate safety data. METHODS: We present a case of 40-year-old female patient who developed significant pulmonary toxicity secondary to e cigarette use and searched existing literature relevant to the case...
February 2, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29392079/novel-modification-of-potassium-chloride-induced-cardiac-arrest-model-for-aged-mice
#16
Huaqin Liu, Zhui Yu, Ying Li, Bin Xu, Baihui Yan, Wulf Paschen, David S Warner, Wei Yang, Huaxin Sheng
Experimental cardiac arrest (CA) in aging research is infrequently studied in part due to the limitation of animal models. We aimed to develop an easily performed mouse CA model to meet this need. A standard mouse KCl-induced CA model using chest compressions and intravenous epinephrine for resuscitation was modified by blood withdrawal prior to CA onset, so as to decrease the requisite KCl dose to induce CA by decreasing the circulating blood volume. The modification was then compared to the standard model in young adult mice subjected to 8 min CA...
February 2018: Aging and Disease
https://www.readbyqxmd.com/read/29391379/training-approaches-for-the-deployment-of-a-mechanical-chest-compression-device-a-randomised-controlled-manikin-study
#17
Keith Couper, Rochelle M Velho, Tom Quinn, Anne Devrell, Ranjit Lall, Barry Orriss, Joyce Yeung, Gavin D Perkins
OBJECTIVES: To evaluate the effect of training strategy on team deployment of a mechanical chest compression device. DESIGN: Randomised controlled manikin trial. SETTING: Large teaching hospital in the UK. PARTICIPANTS: Twenty teams, each comprising three clinicians. Participating individuals were health professionals with intermediate or advanced resuscitation training. INTERVENTIONS: Teams were randomised in a 1:1 ratio to receive either standard mechanical chest compression device training or pit-crew device training...
February 1, 2018: BMJ Open
https://www.readbyqxmd.com/read/29390347/transcatheter-closure-of-a-huge-iatrogenic-atrial-septal-defect-a-case-report
#18
Yong Yang, Xi Li, Mao Chen, Yuan Feng
RATIONALE: Iatrogenic atrial septal defects caused by cardiac surgery are rare complications that are traditionally repaired through reoperations; unfortunately, reoperations are accompanied by high risk and trauma. PATIENT CONCERNS: Herein, we report a rare case of a huge atrial septal defect after mitral and aortic mechanical valve replacement. DIAGNOSES: Transesophageal echocardiography revealed a 20 × 33 mm atrial septal defect with a mainly left-to-right shunt and bidirectional shunt...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29386888/predictors-of-pneumonia-on-routine-chest-radiographs-in-patients-with-copd-a-post-hoc-analysis-of-two-1-year-randomized-controlled-trials
#19
David B Rubin, Harris A Ahmad, Michael O'Neal, Sophie Bennett, Sally Lettis, Dmitry V Galkin, Courtney Crim
Background: Patients with COPD are at risk for life-threatening pneumonia. Although anatomical abnormalities in the thorax may predispose to pneumonia, those abnormalities identified on routine chest X-rays (CXRs) in patients with COPD have not been studied to better understand pneumonia risk. Methods: We conducted a post hoc exploratory analysis of data from two replicate year-long clinical trials assessing the impact of fluticasone furoate-vilanterol versus vilanterol alone on COPD exacerbations (GSK studies: HZC102871/NCT01009463 and HZC102970/NCT01017952)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29386758/challenges-in-management-of-pediatric-life-threatening-neck-and-chest-trauma
#20
Shilpa Sharma, Biplab Mishra, Amit Gupta, Kapil Dev Soni, Richa Aggarwal, Subodh Kumar
Introduction: Neck and thoracic trauma in children pose unforeseen challenges requiring variable management strategies. Here, we describe some unusual cases. Patients and Methods: Pediatric cases of unusual neck and thoracic trauma prospectively managed from April 2012 to March 2014 at a Level 1 trauma center were studied for management strategies, outcome, and follow-up. Results: Six children with a median age of 5.5 (range 2-10) years were managed...
January 2018: Journal of Indian Association of Pediatric Surgeons
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