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https://www.readbyqxmd.com/read/29933031/social-influences-on-microglial-reactivity-and-neuronal-damage-after-cardiac-arrest-cardiopulmonary-resuscitation
#1
Monica M Gaudier-Diaz, Adam H Haines, Ning Zhang, A Courtney DeVries
Social isolation presents a risk factor and worsens outcome to cerebrovascular diseases; however, the underlying mechanisms remain underspecified. This study examines the effect of social environment on microglial reactivity after global cerebral ischemia, to test the hypothesis that social isolation leads to greater microglial responses. Adult female and male mice were pair-housed or socially isolated for one week prior to cardiac arrest/cardiopulmonary resuscitation (CA/CPR) or the sham procedure, and following either 2 or 24 h of reperfusion, microglia samples were enriched and analyzed for gene expression...
June 19, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29924661/the-application-of-mechanical-diagnosis-and-therapy-on-hip-osteoarthritis-a-case-report
#2
Lindsay Carlton, Joseph R Maccio, Joseph G Maccio, Colin McGowan
BACKGROUND: The prevalence and cost of hip osteoarthritis (OA) is rising. Mechanical diagnosis and therapy (MDT) is an orthopedic classification and treatment system based on mechanical and symptomatic response to repeated and sustained end-range movements. There has been no investigation of the association between MDT and patients diagnosed with hip OA. CASE DESCRIPTION: This case report presents a 71-year-old female diagnosed with hip OA and matching the currently accepted clinical prediction rule (CPR) for symptomatic hip OA...
June 20, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29921283/estimation-of-the-variations-in-mechanical-impedance-between-the-actuator-and-the-chest-and-the-power-delivered-to-the-chest-during-cardiopulmonary-resuscitation-using-machine-embedded-sensors
#3
Seong Wook Choi, Do Yeon Lee, Kyoung Won Nam
BACKGROUND: To reduce the risk of patient damage and complications during the cardiopulmonary resuscitation (CPR) process in emergency situations, it is necessary to monitor the status of the patient and the quality of CPR while CPR processing without additional bio-signal measurement devices. In this study, an algorithm is proposed to estimate the mechanical impedance (MI) between an actuator of the CPR machine and the chest of the patient, and to estimate the power delivered to the chest of the patient during the CPR process...
June 19, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29893618/race-ethnicity-socioeconomic-status-and-healthcare-intensity-at-the-end-of-life
#4
Crystal E Brown, Ruth A Engelberg, Rashmi Sharma, Lois Downey, James A Fausto, James Sibley, William Lober, Nita Khandelwal, Elizabeth T Loggers, J Randall Curtis
BACKGROUND: Although racial/ethnic minorities receive more intense, nonbeneficial healthcare at the end of life, the role of race/ethnicity independent of other social determinants of health is not well understood. OBJECTIVES: Examine the association between race/ethnicity, other key social determinants of health, and healthcare intensity in the last 30 days of life for those with chronic, life-limiting illness. SUBJECTS: We identified 22,068 decedents with chronic illness cared for at a single healthcare system in Washington State who died between 2010 and 2015 and linked electronic health records to death certificate data...
June 12, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29892226/blood-shift-during-cough-negligible-or-significant
#5
Antonella LoMauro, Andrea Aliverti
Rationale: It was reported how forceful rhythmic coughing can provide effective blood flow during ventricular fibrillation without direct chest compression. This mechanism of cough-assisted cardiopulmonary resuscitation constitutes a form of "cardiac massage" secondary to the intrathoracic and intra-abdominal pressure changes during cough. We have previously shown that significant blood shifts (BSs) occurs from the thorax to the extremities during expulsive maneuvers and that abdominal pressure controls the outflow of blood from the splanchnic vasculature...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29863638/characteristics-risk-factors-and-outcomes-of-extracorporeal-membrane-oxygenation-use-in-pediatric-cardiac-icus-a-report-from-the-pediatric-cardiac-critical-care-consortium-registry
#6
Marissa A Brunetti, J William Gaynor, Lauren B Retzloff, Jessica L Lehrich, Mousumi Banerjee, Venugopal Amula, David Bailly, Darren Klugman, Josh Koch, Javier Lasa, Sara K Pasquali, Michael Gaies
OBJECTIVES: Cardiopulmonary failure in children with cardiac disease differs from the general pediatric critical care population, yet the epidemiology of extracorporeal membrane oxygenation support in cardiac ICUs has not been described. We aimed to characterize extracorporeal membrane oxygenation utilization and outcomes across surgical and medical patients in pediatric cardiac ICUs. DESIGN: Retrospective analysis of the Pediatric Cardiac Critical Care Consortium registry to describe extracorporeal membrane oxygenation frequency and outcomes...
June 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29862605/injecting-nmda-and-ro-25-6981-in-insular-cortex-induce-neuroplastic-changes-and-neuropathic-pain-like-behavior
#7
Min-Sik Yoon, Chin-Su Koh, Jihyeon Lee, Jaewoo Shin, Chanho Kong, Hyun Ho Jung, Jin Woo Chang
BACKGROUND: Neuropathic pain is associated with abnormal sensitivity of the central nervous system. Although the mechanism underlying the development of sensitization remains to be fully elucidated, recent studies have reported that neuroplastic changes in the pain circuitry may be involved in hypersensitivity associated with neuropathic pain. However, it is difficult to investigate such phenomena in existing animal pain model. Therefore, in this study, we developed a novel animal model-the circuit plasticity reconstruction (CPR) model-to mimic central sensitization associated with neuroplastic changes...
June 4, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29843753/mechanical-cpr-who-when-how
#8
REVIEW
Kurtis Poole, Keith Couper, Michael A Smyth, Joyce Yeung, Gavin D Perkins
In cardiac arrest, high quality cardiopulmonary resuscitation (CPR) is a key determinant of patient survival. However, delivery of effective chest compressions is often inconsistent, subject to fatigue and practically challenging.Mechanical CPR devices provide an automated way to deliver high-quality CPR. However, large randomised controlled trials of the routine use of mechanical devices in the out-of-hospital setting have found no evidence of improved patient outcome in patients treated with mechanical CPR, compared with manual CPR...
May 29, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29807480/life-sustaining-procedures-palliative-care-consultation-and-do-not-resuscitate-status-in-dying-patients-with-copd-in-us-hospitals-2010-2014
#9
Jay J Shen, Eunjeong Ko, Pearl Kim, Sun Jung Kim, Yong-Jae Lee, Jae-Hoon Lee, Ji Won Yoo
AIM: Little is known regarding the extent to which dying patients with chronic obstructive pulmonary disease (COPD) receive life-sustaining procedures and palliative care in US hospitals. We examined temporal trends and the impact of palliative care on the use of life-sustaining procedures in this population. MATERIALS AND METHODS: A retrospective nationwide cohort analysis was performed using weighted National Inpatient Sample (NIS) data obtained from 2010 to 2014...
January 1, 2018: Journal of Palliative Care
https://www.readbyqxmd.com/read/29788845/brain-perfusion-evaluated-by-regional-tissue-oxygenation-as-a-possible-quality-indicator-of-ongoing-cardiopulmonary-resuscitation-an-experimental-porcine-cardiac-arrest-study
#10
Tomáš Bouček, Mikuláš Mlček, Petra Krupičková, Michal Huptych, Tomáš Belza, Otomar Kittnar, Aleš Linhart, Jan Bělohlávek
INTRODUCTION: Relationship between regional tissue oxygenation (rSO2 ) and microcirculatory changes during cardiac arrest (CA) are still unclear. Therefore, we designed an experimental study to correlate rSO2 , microcirculation and systemic hemodynamic parameters in a porcine model of CA. METHODS: Ventricular fibrillation was induced in 24 female pigs (50±3kg) and left for three minutes untreated followed by five minutes of mechanical CPR. Regional and peripheral saturations were assessed by near-infrared spectroscopy, sublingual microcirculation by Sidestream Dark Field technology and continuous hemodynamic parameters, including systemic blood pressure (MAP) and carotid blood flow (CF), during baseline, CA and CPR periods...
May 2018: Perfusion
https://www.readbyqxmd.com/read/29781479/substrate-mediated-redox-partner-selectivity-of-cytochrome-p450
#11
Katherine A Gentry, Meng Zhang, Sang-Choul Im, Lucy Waskell, Ayyalusamy Ramamoorthy
Investigating the interplay between cytochrome-P450 and its redox partners (CPR and cytochrome-b5) is vital for understanding the metabolism of most hydrophobic drugs. Dynamic structural interactions with the ternary complex, with and without substrates, captured by NMR reveal a gating mechanism for redox partners to promote P450 function.
May 31, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29780466/step-growth-titanium-catalysed-dehydropolymerisation-of-amine-boranes
#12
Titel Jurca, Theresa Dellermann, Naomi E Stubbs, Diego A Resendiz-Lara, George R Whittell, Ian Manners
Precatalysts active for the dehydropolymerisation of primary amine-boranes are generally based on mid or late transition metal. We have found that the activity of the precatalyst system formed from CpR 2 TiCl2 and 2 n BuLi towards the dehydrogenation of the secondary amine-borane Me2 NH·BH3 , to yield the cyclic diborazane [Me2 N-BH2 ]2 , increases dramatically with increasing electron-donating character of the cyclopentadienyl rings (CpR ). Application of the most active precatalyst system (CpR = η-C5 Me5 ) to the primary amine-borane MeNH2 ·BH3 enabled the first synthesis of high molar mass poly( N -methylaminoborane), [MeNH-BH2 ] n , the BN analogue of polypropylene, by an early transition metal such as catalyst...
April 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29764553/-interposed-abdominal-pulling-pressing-cardiopulmonary-resuscitation-improve-the-resuscitation-effect-for-patients-with-cardiac-arrest
#13
Dabing Wang, Xiaonan Feng, Yujuan Han
OBJECTIVE: To study the impact of interposed abdominal pulling-pressing cardiopulmonary resuscitation (IAPP-CPR) for patients with cardiac arrest (CA). METHODS: A prospective study was conducted. A total of 122 CA patients admitted to Department of Emergency of Shandong Provincial Mining Industry Group Company Central Hospital from July 2013 to December 2017 were enrolled. They were divided into standard cardiopulmonary resuscitation (S-CPR) group (n = 62) and IAPP-CPR group (n = 60) according to order of admission...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29750875/ulinastatin-alleviates-neurological-deficiencies-evoked-by-transient-cerebral-ischemia-via-improving-autophagy-nrf-2-are-and-apoptosis-signals-in-hippocampus
#14
Xiao-Ming Jiang, Jing-Hai Hu, Lu-Lu Wang, Chi Ma, Xu Wang, Xiao-Liang Liu
Ulinastatin [or called as urinary trypsin inhibitor (UTI)] plays a role in regulating neurological deficits evoked by transient cerebral ischemia. However, the underlying mechanisms still need to be determined. The present study was to examine the effects of UTI on autophagy, Nrf2-ARE and apoptosis signal pathway in the hippocampus in the process of neurological functions after cerebral ischemia using a rat model of cardiac arrest (CA). CA was induced by asphyxia followed by cardiopulmonary resuscitation (CPR) in rats...
May 10, 2018: Physiological Research
https://www.readbyqxmd.com/read/29746986/efficacy-and-safety-of-mechanical-versus-manual-compression-in-cardiac-arrest-a-bayesian-network-meta-analysis
#15
REVIEW
Safi U Khan, Ahmad N Lone, Swapna Talluri, Muhammad Z Khan, Muhammad U Khan, Edo Kaluski
AIM: To compare relative efficacy and safety of mechanical compression devices (AutoPulse and LUCAS) with manual compression in patients with cardiac arrest undergoing cardiopulmonary resuscitation (CPR). METHODS: For this Bayesian network meta-analysis, seven randomized controlled trials (RCTs) were selected using PubMed/Medline, EMBASE, and CENTRAL (Inception- 31 October 2017). For all the outcomes, median estimate of odds ratio (OR) from the posterior distribution with corresponding 95% credible interval (Cr I) was calculated...
May 7, 2018: Resuscitation
https://www.readbyqxmd.com/read/29739857/how-ventilation-is-delivered-during-cardiopulmonary-resuscitation-an-international-survey
#16
Ricardo Luiz Cordioli, Laurent Brochard, Laurent Suppan, Aissam Lyazidi, François Templier, Abdo Khoury, Stephane Delisle, Dominique Savary, Jean-Christophe Richard
BACKGROUND: Recommendations regarding ventilation during cardiopulmonary resuscitation (CPR) are based on a low level of scientific evidence. We hypothesized that practices about ventilation during CPR might be heterogeneous and may differ worldwide. To address this question, we surveyed physicians from several countries on their practices during CPR. METHODS: We used a Web-based opinion survey. Links to the survey were sent by e-mail newsletters and displayed on the Web sites of medical societies involved in CPR practice from December 2013 to March 2014...
May 8, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29737259/refractory-out-of-hospital-cardiac-arrest
#17
Madhan Shanmugasundaram, Kapildeo Lotun
Refractory out of hospital cardiac arrest is a common problem that is associated with poor overall survival rates and neurological outcomes. There are various definitions that have been used but the most accepted one is cardiac arrest that requires more than 10 minutes of cardiopulmonary resuscitation (CPR) efforts or more than 3 defibrillation attempts. There have been different pharmacologic and non-pharmacologic therapies that were studied in these patients. None of the antiarrhythmic or vasopressor medications have been consistently shown to improve survival or neurological outcomes in this subset of patients...
May 7, 2018: Current Cardiology Reviews
https://www.readbyqxmd.com/read/29729387/characterisation-of-anopheles-gambiae-heme-oxygenase-and-metalloporphyrin-feeding-suggests-a-potential-role-in-reproduction
#18
Christopher S Spencer, Cristina Yunta, Glauber Pacelli Gomes de Lima, Kay Hemmings, Lu-Yun Lian, Gareth Lycett, Mark J I Paine
The mosquito Anopheles gambiae is the principal vector for malaria in sub-Saharan Africa. The ability of A. gambiae to transmit malaria is strictly related to blood feeding and digestion, which releases nutrients for oogenesis, as well as substantial amounts of highly toxic free heme. Heme degradation by heme oxygenase (HO) is a common protective mechanism, and a gene for HO exists in the An. gambiae genome HO (AgHO), although it has yet to be functionally examined. Here, we have cloned and expressed An. gambiae HO (AgHO) in E...
July 2018: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29727706/effects-of-head-up-vs-supine-cpr-on-cerebral-oxygenation-and-cerebral-metabolism-a-prospective-randomized-porcine-study
#19
Gabriel Putzer, Patrick Braun, Judith Martini, Ines Niederstätter, Julia Abram, Andrea Katharina Lindner, Sabrina Neururer, Miriam Mulino, Bernhard Glodny, Raimund Helbok, Peter Mair
BACKGROUND: Recent studies have shown that during cardiopulmonary resuscitation (CPR) head-up position (HUP) as compared to standard supine position (SUP) decreases intracranial pressure (ICP) and increases cerebral perfusion pressure (CPP). The impact of this manoeuvre on brain oxygenation and metabolism is not clear. We therefore investigated HUP as compared to SUP during basic life support (BLS) CPR for their effect on brain oxygenation and metabolism. METHODS: Twenty pigs were anaesthetized and instrumented...
May 1, 2018: Resuscitation
https://www.readbyqxmd.com/read/29722926/a-minimal-functional-complex-of-cytochrome-p450-and-fbd-of-cytochrome-p450-reductase-in-nanodiscs
#20
Elke Prade, Mukesh Mahajan, Sang-Choul Im, Meng Zhang, Katherine A Gentry, G M Anantharamaiah, Lucy Waskell, Ayyalusamy Ramamoorthy
Structural interactions that enable electron transfer to cytochrome-P450 (CYP450) from its redox partner CYP450-reductase (CPR) are a vital prerequisite for its catalytic mechanism. The first structural model for the membrane-bound functional complex to reveal interactions between the full-length CYP450 and a minimal domain of CPR is now reported. The results suggest that anchorage of the proteins in a lipid bilayer is a minimal requirement for CYP450 catalytic function. Akin to cytochrome-b5 (cyt-b5 ), Arg 125 on the C-helix of CYP450s is found to be important for effective electron transfer, thus supporting the competitive behavior of redox partners for CYP450s...
May 3, 2018: Angewandte Chemie
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