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https://www.readbyqxmd.com/read/28091558/soluble-urokinase-receptor-supar-predicts-microalbuminuria-in-patients-at-risk-for-type-2-diabetes-mellitus
#1
Martina Guthoff, Robert Wagner, Elko Randrianarisoa, Erifili Hatziagelaki, Andreas Peter, Hans-Ulrich Häring, Andreas Fritsche, Nils Heyne
Early identification of patients at risk of developing diabetic nephropathy is essential. Elevated serum concentrations of soluble urokinase receptor (suPAR) associate with diabetes mellitus and predict onset and loss of renal function in chronic kidney disease. We hypothesize, that suPAR may be an early risk indicator for diabetic nephropathy, preceding microalbuminuria. The relationship of baseline suPAR and incident microalbuminuria was assessed in a prospective long-term cohort of subjects at increased risk for type 2 diabetes (TULIP, n = 258)...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28090093/upar-promotes-tumor-like-biologic-behaviors-of-fibroblast-like-synoviocytes-through-pi3k-akt-signaling-pathway-in-patients-with-rheumatoid-arthritis
#2
Yan Liu, Yun Feng Pan, You-Qiu Xue, Lin-Kai Fang, Xing-Hua Guo, Xin Guo, Meng Liu, Bi-Yao Mo, Meng-Ru Yang, Fang Liu, Yun-Ting Wu, Nancy Olsen, Song Guo Zheng
Urokinase-type plasminogen activator receptor (uPAR), is a multifunctional receptor on cell surface, widely present in endothelial cells, fibroblasts, and a variety of malignant cells. Current studies have suggested that uPAR overexpressed on synovial tissues or in synovial fluid or plasma in patients with rheumatoid arthritis (RA). However, there are limited researches regarding the role of uPAR on fibroblast-like synoviocytes of rheumatoid arthritis (RA-FLSs) and its underlying mechanisms. Here, our studies show that the expression of uPAR protein was significantly higher in fibroblast-like synoviocytes (FLSs) from RA than those from osteoarthritis or traumatic injury patients...
January 16, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28086938/alpha-enolase-eno1-controls-alpha-v-beta-3-integrin-expression-and-regulates-pancreatic-cancer-adhesion-invasion-and-metastasis
#3
Moitza Principe, Simone Borgoni, Mariafrancesca Cascione, Michelle Samuel Chattaragada, Sammy Ferri-Borgogno, Michela Capello, Sara Bulfamante, Jennifer Chapelle, Francesca Di Modugno, Paola Defilippi, Paola Nisticò, Paola Cappello, Chiara Riganti, Stefano Leporatti, Francesco Novelli
BACKGROUND: We have previously shown that in pancreatic ductal adenocarcinoma (PDA) cells, the glycolytic enzyme alpha-enolase (ENO1) also acts as a plasminogen receptor and promotes invasion and metastasis formation. Moreover, ENO1 silencing in PDA cells induces oxidative stress, senescence and profoundly modifies PDA cell metabolism. Although anti-ENO1 antibody inhibits PDA cell migration and invasion, little is known about the role of ENO1 in regulating cell-cell and cell-matrix contacts...
January 13, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28076322/aeroallergen-der-p-2-promotes-motility-of-human-non-small-cell-lung-cancer-cells-via-toll-like-receptor-mediated-up-regulation-of-urokinase-type-plasminogen-activator-and-integrin-focal-adhesion-kinase-signaling
#4
Chun-Hsiang Lin, Hui-Han Lin, Cheng-Yi Kuo, Shao-Hsuan Kao
House dust mite (HDM) allergens are one of the major causes leading to respiratory hypersensitiveness and airway remodeling. Here we hypothesized that a major HDM allergen Der p 2 could increase cell motility and invasiveness of non-small cell lung cancer (NSCLC) cells. Our results showed that low dose (1 and 3 μg/mL) recombinant Der p 2 protein (DP2) enhanced the migration and invasiveness of human NSCLC cell A549, H1299 and CL1-5, but nonsignificantly altered their growth. Further investigation revealed that integrin αV level was increased and its downstream signaling including focal adhesion kinase (FAK) and paxillin were activated in A549 cells exposed to DP2...
January 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28073983/a-novel-embryo-culture-media-supplement-that-improves-pregnancy-rates-in-mice
#5
A R Highet, T Bianco-Miotto, K G Pringle, A Peura, S Bent, J Zhang, M B Nottle, J G Thompson, C T Roberts
The preimplantation embryo in vivo is exposed to numerous growth factors in the female reproductive tract, which are not recapitulated in embryo culture media in vitro The IGF2 and plasminogen activator systems facilitate blastocyst development. We hypothesized that the addition of IGF2 in combination with urokinase plasminogen activator (uPA) and plasminogen could improve rates of blastocyst hatching and implantation in mice. B6BcF1 and CBAB6F2 mouse embryos were divided into one of four supplemented culture media treatment groups: (1) control (media only); (2) 12...
March 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28070042/-effect-of-jianpi-jiedu-formula-on-tumor-angiogenesis-relevant-genes-expression-in-colorectal-cancer
#6
Dan Mao, Sanlin Lei, Jin'an Ma, Li Shi, Shaofan Zhang, Jianhua Huang, Xinyi Liu, Dengfeng Ding, Yingjin Zhang, Lei Feng, Sifang Zhang
To investigate the effect of the jianpi-jiedu formula (JPJD) on the expression of angiogenesis-relevant genes in colon cancer.
 Methods: Crude extract was obtained from JPJD by water extract method. The effect of JPJD crude extract on colon cancer cell proliferation capacity was determined by MTT assays. The IC50 value was calculated by GraphPad Prism5 software. Affymetrix gene expression profiling chip was used to detect significant differences in expressions of genes after JPJD intervention, and pathway enrichment analysis was performed to analyze the differentially expressed genes...
December 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28064304/evaluation-of-ophthalmic-artery-branch-retrograde-intervention-in-the-treatment-of-central-retinal-artery-occlusion-crao
#7
Runsheng Wang, Lu Qian, Yi Wang, Yi Zheng, Shanshuang Du, Tao Lei, Peilin Lv, Tan Long, Wenjun Wang
BACKGROUND Central retinal artery occlusion (CRAO) is the occlusion of the central retinal artery resulting in retinal infarction and acute vision loss. Digital subtraction angiography (DSA)-guided superselective ophthalmic artery or selective carotid thrombolysis remains the preferred treatment method for CRAO. This study aimed to evaluate the safety and clinical efficacy of the novel ophthalmic artery branch retrograde thrombolytic intervention for CRAO. MATERIAL AND METHODS Fifty patients with monocular CRAO were enrolled, including 28 males and 22 females (mean age: 55...
January 8, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28062404/endothelial-to-mesenchymal-transition-contributes-to-endothelial-dysfunction-and-dermal-fibrosis-in-systemic-sclerosis
#8
Mirko Manetti, Eloisa Romano, Irene Rosa, Serena Guiducci, Silvia Bellando-Randone, Amato De Paulis, Lidia Ibba-Manneschi, Marco Matucci-Cerinic
OBJECTIVE: Systemic sclerosis (SSc) features multiorgan fibrosis orchestrated predominantly by activated myofibroblasts. Endothelial-to-mesenchymal transition (EndoMT) is a transdifferentiation by which endothelial cells (ECs) lose their specific morphology/markers and acquire myofibroblast-like features. Here, we determined the possible contribution of EndoMT to the pathogenesis of dermal fibrosis in SSc and two mouse models. METHODS: Skin sections were immunostained for endothelial CD31 or vascular endothelial (VE)-cadherin in combination with α-smooth muscle actin (α-SMA) myofibroblast marker...
January 6, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28060552/the-root-extract-of-gentiana-macrophylla-pall-alleviates-b19-ns1-exacerbated-liver-injuries-in-nzb-w-f1-mice
#9
Ming-Jen Sheu, Chun-Ching Chiu, Deng-Jye Yang, Tsai-Ching Hsu, Bor-Show Tzang
The nonstructural protein NS1 of human parvovirus B19 (B19) is known to exacerbate disease activity in systemic lupus erythematosus (SLE). However, no specific medicine for B19 infection is available. The roots of Gentiana macrophylla Pall. (GM), the traditional Chinese medicine "Qinjiao," have been used for centuries to treat rheumatic disease, including SLE. Herein, we aimed to investigate the effects of GM root extract (100 and 300 mg/kg body weight) on B19-NS1-exacerbated liver injury in NZB/W F1 mice; liver tissues were assessed by hematoxylin-eosin staining and immunoblotting...
January 6, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28049381/kidney-disease-in-puumala-hantavirus-infection
#10
Jukka Mustonen, Tuula Outinen, Outi Laine, Ilkka Pörsti, Antti Vaheri, Satu Mäkelä
Acute kidney injury (AKI) remains a predominant clinical expression of nephropathia epidemica (NE). Its pathogenesis is not yet fully understood. Here, we describe the tissue injury comprehensively and present new data aimed to characterize the injury and explain its pathophysiology. When compared to tubulointerstitial nephritis of a wide variety of other aetiologies, a high degree of proteinuria is a distinguished trait of NE, a finding that is also helpful in the clinical suspicion of the disease. Recently, novel biomarkers for the prediction of severe AKI, including neutrophil gelatinase-associated lipocalin (NGAL), have been identified and ultrastructural tissue changes have been more accurately described...
January 3, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28039715/identification-of-differential-pathways-in-papillary-thyroid-carcinoma-utilizing-pathway-co-expression-analysis
#11
Wei-Hai Qiu, Gui-Yan Chen, Lu Cui, Ting-Ming Zhang, Feng Wei, Yong Yang
PURPOSE: To identify differential pathways between papillary thyroid carcinoma (PTC) patients and normal controls utilizing a novel method which combined pathway with co-expression network. METHODS: The proposed method included three steps. In the first step, we conducted pretreatments for background pathways and gained representative pathways in PTC. Subsequently, a co-expression network for representative pathways was constructed using empirical Bayes (EB) approach to assign a weight value for each pathway...
November 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28039488/upar-targeted-optical-near-infrared-nir-fluorescence-imaging-and-pet-for-image-guided-surgery-in-head-and-neck-cancer-proof-of-concept-in-orthotopic-xenograft-model
#12
Anders Christensen, Karina Juhl, Morten Persson, Birgitte Wittenborg Charabi, Jann Mortensen, Katalin Kiss, Giedrius Lelkaitis, Niclas Rubek, Christian von Buchwald, Andreas Kjær
PURPOSE: Urokinase-like Plasminogen Activator Receptor (uPAR) is overexpressed in a variety of carcinoma types, and therefore represents an attractive imaging target. The aim of this study was to assess the feasibility of two uPAR-targeted probes for PET and fluorescence tumor imaging in a human xenograft tongue cancer model. EXPERIMENTAL DESIGN AND RESULTS: Tumor growth of tongue cancer was monitored by bioluminescence imaging (BLI) and MRI. Either ICG-Glu-Glu-AE105 (fluorescent agent) or 64Cu-DOTA-AE105 (PET agent) was injected systemically, and fluorescence imaging or PET/CT imaging was performed...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/28035371/the-anti-metastatic-effects-of-the-phytoestrogen-arctigenin-on-human-breast-cancer-cell-lines-regardless-of-the-status-of-er-expression
#13
Thressi Maxwell, So-Young Chun, Kyu-Shik Lee, Soyoung Kim, Kyung-Soo Nam
Arctigenin is a plant lignan extracted from Arctium lappa that has been shown to have estrogenic properties. In spite of the health benefits of phytoestrogens reducing the risk of osteoporosis, heart disease, and menopausal symptoms, its benefits against the risk of breast cancer have not been fully elucidated. Thus, we investigated the effects of arctigenin on metastasis of breast cancer using both estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 human breast cancer cell lines to see if the effects are dependent on the status of ER expression...
December 29, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27992087/urokinase-type-plasminogen-activator-modulates-mammalian-circadian-clock-phase-regulation-in-tissue-type-plasminogen-activator-knockout-mice
#14
Joanna M Cooper, Ashutosh Rastogi, Jessica A Krizo, Eric M Mintz, Rebecca A Prosser
Glutamate phase shifts the circadian clock in the mammalian suprachiasmatic nucleus (SCN) by activating NMDA receptors. Tissue-type plasminogen activator (tPA) gates phase shifts by activating plasmin to generate m(ature)BDNF, which binds TrkB receptors allowing clock phase shifts. Here we investigate phase shifting in tPA knockout (tPA(-/-) ; B6.129S2-Plat(tm1Mlg) /J) mice, and identify urokinase-type plasminogen activator (uPA) as an additional circadian clock regulator. Behavioral activity rhythms in tPA(-/-) mice entrain to a light-dark (LD) cycle and phase shift in response to nocturnal light pulses with no apparent loss in sensitivity...
December 19, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27991579/serum-soluble-urokinase-type-plasminogen-activator-receptor-as-a-biological-marker-of-bacterial-infection-in-adults-a-systematic-review-and-meta-analysis
#15
Wentao Ni, Yuliang Han, Jin Zhao, Junchang Cui, Kai Wang, Rui Wang, Youning Liu
The serum concentration of soluble urokinase-type plasminogen activator receptor (suPAR) reflects immune activation. We performed a meta-analysis to evaluate the usefulness of suPAR for the diagnosis and prognosis of bacterial infections. PubMed, Embase and Cochrane Library databases were searched for studies reporting the detection of suPAR in adult patients with bacterial infections. Seventeen studies were selected from 671 studies. The pooled sensitivity and specificity of suPAR for diagnosing infection were 0...
December 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27990353/effect-of-dihydrotestosterone-on-the-expression-of-mucin-1-and-the-activity-of-wnt-signaling-in-mouse-corneal-epithelial-cells
#16
Li Qin, Cheng Pei, Qian-Yan Kang, Zhao Liu, Li Li
AIM: To explore the effects of the androgen dihydrotestosterone on the expression of mucin 1 (MUC1) and the activity of Wnt signaling in mouse corneal epithelial cells. METHODS: Primary mouse corneal epithelial cells were isolated from the corneas of BALB/c mice. Quantitative real-time polymerase chain reaction, immunofluorescence and Western blot analysis were used to quantify the differential expression of selected genes. The androgen receptor was silenced by transfecting cells with androgen receptor shRNAs...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27989561/cell-penetrating-serpina5-proteinc-inhibitor-pci-more-questions-than-answers
#17
REVIEW
Hanjiang Yang, Margarethe Geiger
SERPINA5 (proteinC inhibitor, plasminogen activator inhibitor-3) is a secreted, extracellular clade A serpin. Its main characteristics are broad protease reactivity and wide tissue distribution (in man). SERPINA5 has originally been described as an inhibitor of activated protein C and independently as an inhibitor of the plasminogen activator urokinase. SERPINA5 binds glycosaminoglycans, phospholipids, and retinoic acid. Glycosaminoglycans and certain phospholipids can modulate its inhibitory activity and specificity...
October 28, 2016: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/27986809/urokinase-type-plasminogen-activator-upa-binding-to-the-upa-receptor-upar-promotes-axonal-regeneration-in-the-central-nervous-system
#18
Paola Merino, Ariel Diaz, Valerie Jeanneret, Fang Wu, Enrique Torre, Lihong Cheng, Manuel Yepes
Axonal injury is a common cause of neurological dysfunction. Unfortunately, in contrast to axons from the peripheral nervous system, the limited capacity of regeneration of central nervous system (CNS) axons is a major obstacle for functional recovery in patients suffering neurological diseases that involve the subcortical white matter. Urokinase-type plasminogen activator (uPA) is a serine proteinase that upon binding to the urokinase-type plasminogen activator receptor (uPAR) catalyzes the conversion of plasminogen into plasmin on the cell surface...
December 16, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27983915/kallistatin-suppresses-cell-proliferation-invasion-and-promotes-apoptosis-in-cervical-cancer-through-blocking-nf-%C3%AE%C2%BAb-signaling
#19
Tao Wang, Fan Shi, JiQuan Wang, Zi Liu, Jin Su
Kallistatin has been recognized as an endogenous angiogenesis inhibitor, and exerts pleiotropic effects in inhibiting tumor growth, migration, apoptosis and inflammation. The purpose of the present study was to investigate the potential role and mechanisms of kallistatin in cervical cancer. We demonstrated that kallistatin effectively inhibited cell proliferation and enhanced apoptosis in a dose-dependent manner. Additionally, kallistatin suppressed migration and invasion activity as well as markedly reduced the expression of matrix-degrading metalloproteinases, progelatinase (MMP-2), MMP-9 and urokinase-type PA (uPA)...
November 24, 2016: Oncology Research
https://www.readbyqxmd.com/read/27983472/characterization-of-two-new-putative-adhesins-of-leptospira-interrogans
#20
Jupciana Figueredo, Gabriela Siqueira, Gisele Souza, Marcos Heinemann, Silvio Vasconcellos, Erica Chapola, Ana Lucia T O Nascimento
We here report the characterization of two novel proteins encoded by the genes LIC11122 and LIC12287, identified in the genome sequences of Leptospira interrogans, annotated, respectively, as a putative sigma factor and hypothetical. . The coding sequences (CDSs) LIC11122 and LIC12287 have signal peptide SPII and SPI and are predicted to be located mainly at the cytoplasm membrane of the bacteria. The genes were cloned and the proteins expressed using Escherichia coli. Proteinase K digestion showed that both proteins are surface exposed...
December 15, 2016: Microbiology
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