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Tranplantation

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https://www.readbyqxmd.com/read/27726211/thyroid-hormone-use-during-cardiac-transplant-organ-procurement
#1
Lauren B Cooper, Carmelo A Milano, Melissa Williams, Wendy Swafford, Donna Croezen, Adrian B Van Bakel, Joseph G Rogers, Chetan B Patel
BACKGROUND: Acute hypothyroidism after brain death results in hemodynamic impairments that limit availability of donor hearts. Thyroid hormone infusions can halt that process and lead to increased utilization of donor organs, but prolonged use of thyroid replacement has not been well studied. METHODS: We developed a 15-question survey regarding policies, procedures, and reporting of thyroid hormone use by organ procurement organizations (OPOs). The survey was posted for 5 weeks on the Association of OPOs Portal...
December 2016: Clinical Transplantation
https://www.readbyqxmd.com/read/27538160/-feasibility-study-of-transplantation-of-penile-corpus-cavernosum-and-major-pelvic-ganglion-in-renal-subserous-region
#2
Y D Xu, R L Guan, Y Y Wu, H E Lei, B C Yang, H X Li, L Wang, Y L Guo, Z C Xin
OBJECTIVE: To study the feasibility of transplantation of normal rat penile corpus cavernosum and major pelvic ganglion (MPG) into the renal subserous region of a Nu/Nu mouse based on allograft technology. METHODS: Penile corpus cavernosum and MPG, harvested from Sprague-Dawley (SD) rats under sterile condition, were transplanted underneath the kidney capsule of Nu/Nu mice through the microsurgery instruments and surgery microscope. The histopathologic changes and cellular proliferation in the transplanted penile corpus cavernosum and MPG were then analyzed at the end of 1week and 4 weeks after transplantation...
February 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27508705/-op-4b-10-left-ventricular-mass-after-renal-transplantation-metaanalysis-of-cross-sectional-and-longitudinal-studies
#3
B Schmidt, K Bergmann, J Kaufeld, A Melk
OBJECTIVE: Left ventriuclar mass (LVM) is a strong predictor of cardiovascular events. In patients with chronic kidney disease and in patients on dialysis left ventricular hypertrophy is highly prevalent. Overcoming uremia by renal transplantation might improve LVM. However, after transplantation treatment with steroids and calcineurin inhibitors increases blood pressure and therefore might counteract the positive effect of restoring renal function.We performed a metaanalysis of the available evidence from observational studies in patientts after renal tranplantation...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27041281/-perspectives-of-the-cell-therapy-in-ophthalmology1-the-application-of-stem-cells-in-the-regeneration-of-damaged-surface-of-the-eye
#4
E Javorková, V Holáň
UNLABELLED: Regeneration of corneal epithelium is secured by a population of limbal stem cells (LSC), which are located in the basal part of the limbal epithelium. Deficiency in LSC leads to chronic inflammation, scarring and conjunctivization of cornea. Therapy of LSC deficiency consists in transplantation of limbal tissue, cultivated limbal epithelium or more recently in tranplantation of autologous cells including mesenchymal stem cells, oral mucosal epithelial cells or hair follicle-derived stem cells...
February 2016: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/26380530/concentrating-childhood-cancer-treatment-in-the-netherlands
#5
Hans van Goudoever
Paediatric tertiary care is highly centralized in the Netherlands. The country is small (16 million inhabitants, overall unemployment rates were approximately 7 % in 2014, while young adult (< 25 years) unemployment rates were 12 %) with the majority of the population living in Amsterdam and Rotterdam and their neighbouring cities/villages. There are 90 hospitals taking care for children in the Netherlands. Specific types of highly specialized care, such as transplantation, are provided in a maximum of three centres (kidney transplants in 3, bone marrow tranplants in 2, liver transplants in only one center), while neonatal intensive care is offered in 10 hospitals...
2015: Pädiatrie und Pädologie
https://www.readbyqxmd.com/read/26078334/deguelin-inhibits-vasculogenic-function-of-endothelial-progenitor-cells-in-tumor-progression-and-metastasis-via-suppression-of-focal-adhesion
#6
Minh Phuong Nguyen, Dongjin Lee, Se-Hyung Lee, Hye-Eun Lee, Ho-Young Lee, You Mie Lee
Deguelin is a nature-derived chemopreventive drug. Endothelial progenitor cells (EPCs) are bone-marrow (BM)-derived key components to induce new blood vessels in early tumorigenesis and metastasis. Here we determined whether deguelin inhibits EPC function in vitro and in vivo at doses not affecting cancer cell apoptosis. Deguelin significantly reduced the number of EPC colony forming units of BM-derived c-kit+/sca-1+ mononuclear cells (MNCs), proliferation, migration, and adhesion to endothelial cell monolayers, and suppressed incorporation of EPC into tube-like vessel networks when co-cultured with endothelial cells...
June 30, 2015: Oncotarget
https://www.readbyqxmd.com/read/25975844/predominant-role-of-the-hypothalamic-pituitary-axis-not-the-ovary-in-different-types-of-abnormal-cycle-induction-by-postnatal-exposure-to-high-dose-p-tert-octylphenol-in-rats
#7
Midori Yoshida, Sayumi Katashima, Miwa Tahahashi, Ryohei Ichimura, Kaoru Inoue, Kazuyoshi Taya, Gen Watanabe
To determine whether it is the hypothalamic-pituitary axis or the ovary that plays the predominant role in abnormal estrous cycling induction by postnatal exposure to estrogenic compounds, female rats were subcutaneously injected with 100mg/kg p-tert-octylphenol or vehicle for 5 or 15 days after birth (OP-PND5, OP-PND15 or control). Ovaries were exchanged between control and treated groups on PND28. Controls receiving control or OP-PND5 ovaries showed normal cycles within 4 weeks after the exchange, and corpora lutea were detected in transplanted ovaries...
November 2015: Reproductive Toxicology
https://www.readbyqxmd.com/read/25775666/trichodysplasia-spinulosa-in-a-renal-transplant-patient
#8
Alexandre Laroche, Catherine Allard, Myrna Chababi-Atallah, Mélanie Masse, Janie Bertrand
BACKGROUND: Trichodysplasia spinulosa (TS) is a rare skin affection seen in immunocompromised patients, mainly those with solid organ tranplants. OBJECTIVE: To report a case of a patient with classic clinical and pathologic findings for the disease so that physicians caring for this population are aware of the clinical presentation. METHOD: We report the case of a female patient we saw at our clinic with a diagnosis of TS. RESULTS: The diagnosis of TS was confirmed by pathologic findings...
January 2015: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/25622504/-survival-of-bone-marrow-mesenchymal-stem-cells-and-periodontal-ligament-stem-cells-in-cell-sheets
#9
Kangkang An, Hongwei Liu
OBJECTIVE: To evaluate the survival of bone marrow mesenchymal stem cells (BMMSC) and periodontal ligament stem cells (PDLSC) in BMMSC/PDLSC cell sheets which transplanted ectopically into subcutaneous dorsum of nude mice. METHODS: The canine BMMSC and PDLSC from primary culture were tranfected with lentiviral vectors carrying green fluorescent protein (GFP) gene (Lentivirus-GFP) or red fluorescent protein (RFP) gene (Lentivirus-RFP) respectively. The immunophenotypes of GFP-labeled BMMSC and RFP-labeled PDLSC were identified by flow cytometry...
November 2014: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/25617502/cell-autonomous-decrease-in-proliferative-competitiveness-of-the-aged-hepatocyte
#10
Maria Paola Serra, Fabio Marongiu, Michela Marongiu, Antonella Contini, Ezio Laconi
BACKGROUND & AIMS: The regenerative potential of the liver declines with age, this might be dependent on a decrease in the intensity of the stimulus and/or an increased refractoriness of the target. In the present study, we compared the in vivo growth capacity of young and old hepatocytes transplanted into the same host. METHODS: We utilized the retrorsine (RS)-based model for liver repopulation, which provides a specific and effective stimulus for transplanted hepatocytes...
June 2015: Journal of Hepatology
https://www.readbyqxmd.com/read/25543474/-quercetin-enhances-the-anti-leukemic-effect-of-adriamycin
#11
Yan-Qiu Han, Yu Hong, Xiu-Lan Su, Jun-Rui Wang
This study was purposed to explore the anti-leukemic mechanism of quercetin (Que) in vivo and it enhancing chemotherapeutic effect of adriamycin (ADR) by establishing the quercetin-treated P388 transplanted nude mouse model. The P388 leukemic cells in logarithmic growth phase were taken and injected subcutaneously into BALB/c nude mice so as to establish the leukemia-transplanted nude mouse model. The model mice were treated by quercetin, ADR and their combination, and the survival changes of model mice were observed, the hemogram and peripheral blood cell count examination were performed regularly; the cell cycle was detected and the influence of quercetin on cell proliferation was analyzed by flow cytometry; the caspase-3 protein expression level was detected by ELISA; the mRNA and protein changes of NF-κB, BCL-2, BAX were measured by real-time quantitative flourascence PCR and Western blot respectively...
December 2014: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/25537259/chronic-spinal-cord-lesions-respond-positively-to-tranplants-of-mesenchymal-stem-cells
#12
Fernanda Martins de Almeida, Suelen Adriani Marques, Bruna dos Santos Ramalho, Tamires Braga Massoto, Ana Maria Blanco Martinez
PURPOSE: Despite substantial advances in surgical care and rehabilitation, the consequences of spinal cord injury (SCI) continue to present major challenges. Here we investigate whether transplantation of mesenchymal stem cells (MSCs) in mice during the chronic stage of SCI has benefits in terms of morphological and functional outcomes. METHODS: Mice were subjected to laminectomy at the T9 level, followed by a 1 minute spinal cord compression with a vascular clip...
2015: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/25458832/leptin-and-adiponectin-during-the-first-week-after-kidney-transplantation-biomarkers-of-graft-dysfunction
#13
COMPARATIVE STUDY
Isabel Fonseca, José Carlos Oliveira, Josefina Santos, Jorge Malheiro, La Salete Martins, Manuela Almeida, Leonídio Dias, Sofia Pedroso, Luísa Lobato, António Castro Henriques, Denisa Mendonça
CONTEXT AND OBJECTIVE: Based on evidence that leptin and adiponectin are removed from circulation primarily by the kidney, we designed a study to examine the longitudinal changes of these adipokines during the first week after kidney transplantation (KTx) and to test the hypothesis that higher levels of leptin and/or adiponectin could be early biomarkers of delayed graft function (DGF=dialysis requirement during the first post-transplant week) and acute rejection. STUDY DESIGN: Repeated-measures prospective study...
February 2015: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/25175796/complete-donor-t-cell-chimerism-predicts-lower-relapse-incidence-after-standard-double-umbilical-cord-blood-reduced-intensity-conditioning-regimen-allogeneic-transplantation-in-adults
#14
Pierre Peterlin, Jacques Delaunay, Thierry Guillaume, Thomas Gastinne, Béatrice Mahé, Viviane Dubruille, Nicolas Blin, Amandine Le Bourgeois, Eolia Brissot, Laurence Lodé, Steven Le Gouill, Philippe Moreau, Mohamad Mohty, Patrice Chevallier
Double umbilical cord blood (dUCB) allogeneic transplantation after a low-dose total body irradiation, cyclophosphamide, and fludarabine (TCF)-based reduced-intensity conditioning regimen (RIC) is increasingly used in adults lacking a suitable related or unrelated donor. Currently, there are little data regarding the long-term outcome of CD3(+) T cell chimerism (TCC) in this particular setting. Thirty-six adults with various hematological diseases who received dUCB allogeneic transplants conditioned with TCF were included in this retrospective study...
January 2015: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/24842530/t-cell-replete-haploidentical-donor-transplantation-using-post-transplant-cy-an-emerging-standard-of-care-option-for-patients-who-lack-an-hla-identical-sibling-donor
#15
REVIEW
A Bashey, S R Solomon
Availability of an HLA-identical sibling (MRD) or suitably matched unrelated donor (MUD) has historically been a limiting factor in the application of allogeneic hematopoietic transplantation. Although almost all patients have an HLA-haploidentical family donor, prior attempts at transplantation from such donors using T-cell replete grafts and conventional immunosuppression were associated with unacceptable rates of GVHD, and when stringent ex vivo T-cell depletion was used to control GVHD, rates of graft rejection and post-transplant infections were prohibitive...
August 2014: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/24826237/a-family-history-of-dilated-cardiomyopathy-induced-by-viral-myocarditis
#16
Thomas Cognet, Olivier Lairez, Pauline Marchal, Jérôme Roncalli, Michel Galinier
Myocarditis can lead to acute heart failure, cardiogenic shock, or sudden death and later, dilated cardiomyopathy (DCM) with chronic heart failure. We report the cases of two DCM induced by acute and past myocarditis in the same family and expressed by its two main complications within few weeks: an hemodynamic presentation as a fulminant myocarditis rapidly leading to cardiac tranplantation and a rythmologic presentation as an electrical storm leading to catheter ablation of ventricular tachycardia. These cases ask the question of the family predisposition to viral myocarditis leading to DCM...
2012: Case Reports in Cardiology
https://www.readbyqxmd.com/read/24763259/trichodysplasia-spinulosa-in-a-renal-transplant-patient
#17
Alexandre Laroche, Catherine Allard, Myrna Chababi-Atallah, Mélanie Masse, Janie Bertrand
Background:Trichodysplasia spinulosa (TS) is a rare skin affection seen in immunocompromised patients, mainly those with solid organ tranplants.Objective:To report a case of a patient with classic clinical and pathologic findings for the disease so that physicians caring for this population are aware of the clinical presentation.Method:We report the case of a female patient we saw at our clinic with a diagnosis of TS.Results:The diagnosis of TS was confirmed by pathologic findings.Conclusion:TS should be considered in any immunocompromised patient with a papular facial eruption reminiscent of acne vulgaris and with keratotic spiny papules as a distinctive feature...
2014: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/24701065/guidelines-for-prevention-of-hospital-acquired-infections
#18
Yatin Mehta, Abhinav Gupta, Subhash Todi, Sn Myatra, D P Samaddar, Vijaya Patil, Pradip Kumar Bhattacharya, Suresh Ramasubban
These guidelines, written for clinicians, contains evidence-based recommendations for the prevention of hospital acquired infections Hospital acquired infections are a major cause of mortality and morbidity and provide challenge to clinicians. Measures of infection control include identifying patients at risk of nosocomial infections, observing hand hygiene, following standard precautions to reduce transmission and strategies to reduce VAP, CR-BSI, CAUTI. Environmental factors and architectural lay out also need to be emphasized upon...
March 2014: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/24173728/reduction-mammoplasty-borrowing-the-good-points-of-many-techniques
#19
J R Lewis
The purposes of the reduction mammoplasty are: (a) relief of the pain and discomfort of heavy, pendulous breasts; (b) a normal and pleasing appearance with the brassiere in place and the patient clothed; (c) a reasonable, pleasing contour to the breasts, from front and side, without the support of clothing or brassiere; (d) normally sensitive nipples that become erect on stimulation; (e) minimal apparent permanent scarring; (f) ideally, intact ducts to the nipple; (g) a breast of size allowing for examination for breast masses; (h) eradication of breast masses; (i) a happy patient...
December 1976: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/24031908/carriage-frequency-phenotypic-and-genotypic-characteristics-of-staphylococcus-aureus-isolated-from-dialysis-and-kidney-tranplant-patients-at-a-hosptial-in-northern-paran%C3%A3
#20
Luciana Borges Giarola, Rosiane Ribeiro Dos Santos, Maria Cristina Bronharo Tognim, Sueli Donizete Borelli, João Bedendo
The objective of the present study was to determine the frequency of Staphylococcus aureus nasal carriage among dialysis and kidney transplant patients, to identify the antimicrobial resistance profile of these strains and to verify their genetic profiles with the RW3A primer. The study included 159 individuals, comprising 111 dialysis and 48 kidney transplant patients. Of the 48 transplant patients, 75% were positive for S. aureus, whereas 49% of the 111 dialysis patients were carriers. Two samples yielded conflicting results for oxacillin sensitivity between the disk diffusion and minimum inhibitory concentration (MIC) assays: both were sensitive by the disk diffusion assay and resistant by MIC (4 μg/ml)...
July 2012: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
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